Market Movers | Winners: CUE, SOBR, ESPR | Losers: SDOT, CREG, SHPH
On Friday, May 1, the major indices showed mixed performance, with the S&P 500 rising 0.29%, the Dow 30 falling 0.31%, and the Nasdaq 100 rising 0.94%. Stock-level movements were also varied, reflecting company-specific dynamics.

List of Market Winners
The following table shows the list of 10 stocks that generated the highest returns on the last trading day:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | CUE | Cue Biopharma | 106.4% | 232.0% |
| 2 | SOBR | Sobr Safe | 79.9% | -54.1% |
| 3 | ESPR | Esperion Therapeutics | 55.5% | -15.9% |
| 4 | STEX | Streamex | 54.2% | -61.1% |
| 5 | UONE | Urban One | 39.2% | -29.0% |
| 6 | BOOM | DMC Global | 36.1% | 25.7% |
| 7 | PS | Pershing Square | 35.7% | 69.2% |
| 8 | ATOM | Atomera | 35.6% | 401.8% |
| 9 | DRCT | Direct Digital | 34.3% | -71.8% |
| 10 | CERS | Cerus | 34.0% | 32.0% |
List of Market Losers
On the other hand, the following table shows the list of 10 stocks that generated the lowest returns:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | SDOT | Sadot | -51.8% | -61.2% |
| 2 | CREG | Smart Powerr | -38.1% | -58.8% |
| 3 | SHPH | Shuttle Pharmaceuticals | -32.8% | -61.6% |
| 4 | CVM | CEL-SCI | -25.7% | -56.7% |
| 5 | SMMT | Summit Therapeutics | -24.9% | -7.9% |
| 6 | RNTX | Rein Therapeutics | -24.0% | -11.2% |
| 7 | INDP | Indaptus Therapeutics | -23.6% | -26.5% |
| 8 | BAFN | BayFirst Financial | -23.5% | -18.9% |
| 9 | SENS | Senseonics | -22.8% | -7.6% |
| 10 | TREE | LendingTree | -21.7% | -26.9% |
Why does this matter? Significant stock moves – up or down – deserve your attention. Sharp declines in fundamentally strong names can offer smart buying opportunities. And when momentum aligns with solid fundamentals, riding the trend can be highly rewarding.
You can’t predict what happens to individual stocks, but you can prepare. See how the Trefis High Quality Portfolio helps you.
Movers – Last One Week
Analysing over the last one week (5 trading days), stocks moved decisively higher, as seen in the S&P 500 rising 0.91%, the Dow 30 rising 0.55%, and the Nasdaq 100 rising 1.49%. Most stocks saw buying, though some stocks missed out.
List of 1-Week Market Winners
The following table shows the list of 10 stocks that generated the highest returns over the last week:
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | BIGGQ | Former BL Stores | ∞% | 0.0% |
| 2 | AKAN | Akanda | 366.8% | 454.8% |
| 3 | EDSA | Edesa Biotech | 142.3% | 1138.7% |
| 4 | RPGL | Republic Power | 138.7% | -99.2% |
| 5 | SEGG | Sports Entertainment Gaming Global | 86.3% | 67.1% |
| 6 | BAND | Bandwidth | 86.0% | 190.4% |
| 7 | BRLS | Borealis Foods | 82.4% | -17.0% |
| 8 | SOBR | Sobr Safe | 82.0% | -54.1% |
| 9 | XRX | Xerox | 73.1% | 16.2% |
| 10 | CUE | Cue Biopharma | 71.9% | 232.0% |
List of 1-Week Market Losers
Similarly, the following table shows the 10 stocks that were at the bottom in terms of returns:
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | AREB | American Rebel | -95.0% | -100.0% |
| 2 | SNGX | Soligenix | -75.2% | -74.3% |
| 3 | SDOT | Sadot | -69.1% | -61.2% |
| 4 | CMPX | Compass Therapeutics | -61.0% | -63.5% |
| 5 | LABT | Lakewood-Amedex Biotherapeutics | -53.3% | -60.3% |
| 6 | ERAS | Erasca | -53.3% | 169.6% |
| 7 | FCHL | Fitness Champs | -53.0% | -97.5% |
| 8 | GLND | Greenland Energy | -53.0% | -77.5% |
| 9 | POET | POET Technologies | -51.6% | 15.5% |
| 10 | PMI | Picard Medical | -48.2% | -74.9% |
Movers – Last One Month
On a slightly wider timeline over the last one month, stocks moved decisively higher, as seen in the S&P 500 rising 9.96%, the Dow 30 rising 6.30%, and the Nasdaq 100 rising 15.36%. Most stocks saw buying, though some stocks missed out.
List of 1-Month Market Winners
The following table shows the 10 stocks that generated the maximum returns over the last one month:
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | JTAI | Jet AI | 8339.4% | -94.0% |
| 2 | PSTV | Plus Therapeutics | 3808.9% | -52.4% |
| 3 | AKAN | Akanda | 1725.4% | 454.8% |
| 4 | MOBX | Mobix Labs | 733.3% | -12.8% |
| 5 | NXTS | Nexentis Technologies | 606.4% | -60.5% |
| 6 | BBGI | Beasley Broadcast | 505.0% | 309.4% |
| 7 | CUE | Cue Biopharma | 400.5% | 232.0% |
| 8 | XNDU | Xanadu Quantum Technologies | 381.6% | 214.1% |
| 9 | KITT | Nauticus Robotics | 373.9% | 207.5% |
| 10 | MXL | MaxLinear | 336.3% | 342.8% |
List of 1-Month Market Losers
In the same period, these 10 stocks were at the bottom in terms of returns:
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | FCHL | Fitness Champs | -95.9% | -97.5% |
| 2 | AREB | American Rebel | -95.0% | -100.0% |
| 3 | NMTC | NeuroOne Medical Technologies | -84.9% | -84.1% |
| 4 | NXPL | NextPlat | -83.8% | -88.1% |
| 5 | ELAB | PMGC | -82.1% | -92.9% |
| 6 | ASBP | Aspire Biopharma | -79.0% | -96.0% |
| 7 | ADTX | Aditxt | -78.3% | -97.1% |
| 8 | PHGE | BiomX | -76.1% | -57.8% |
| 9 | KIDZ | Classover | -75.9% | -90.5% |
| 10 | LPCN | Lipocine | -74.8% | -71.0% |
Picking winners on a consistent basis is not an easy task – especially given the volatility associated with a single stock. Instead, the Trefis High Quality (HQ) Portfolio, with a collection of 30 stocks, has a track record of comfortably outperforming its benchmark that includes all 3 — the S&P 500, S&P mid-cap, and Russell 2000 indices. Why is that? As a group, HQ Portfolio stocks provided better returns with less risk versus the benchmark index; less of a roller-coaster ride, as evident in HQ Portfolio performance metrics.