Market Movers | Winners: CUE, SOBR, ESPR | Losers: SDOT, CREG, SHPH

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On Friday, May 1, the major indices showed mixed performance, with the S&P 500 rising 0.29%, the Dow 30 falling 0.31%, and the Nasdaq 100 rising 0.94%. Stock-level movements were also varied, reflecting company-specific dynamics.
 

Trefis: RUA Stock Insights

List of Market Winners

The following table shows the list of 10 stocks that generated the highest returns on the last trading day:
 

# Ticker Company Name 1-D
Returns
YTD
Returns
1 CUE Cue Biopharma 106.4% 232.0%
2 SOBR Sobr Safe 79.9% -54.1%
3 ESPR Esperion Therapeutics 55.5% -15.9%
4 STEX Streamex 54.2% -61.1%
5 UONE Urban One 39.2% -29.0%
6 BOOM DMC Global 36.1% 25.7%
7 PS Pershing Square 35.7% 69.2%
8 ATOM Atomera 35.6% 401.8%
9 DRCT Direct Digital 34.3% -71.8%
10 CERS Cerus 34.0% 32.0%

 
List of Market Losers

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On the other hand, the following table shows the list of 10 stocks that generated the lowest returns:
 

# Ticker Company Name 1-D
Returns
YTD
Returns
1 SDOT Sadot -51.8% -61.2%
2 CREG Smart Powerr -38.1% -58.8%
3 SHPH Shuttle Pharmaceuticals -32.8% -61.6%
4 CVM CEL-SCI -25.7% -56.7%
5 SMMT Summit Therapeutics -24.9% -7.9%
6 RNTX Rein Therapeutics -24.0% -11.2%
7 INDP Indaptus Therapeutics -23.6% -26.5%
8 BAFN BayFirst Financial -23.5% -18.9%
9 SENS Senseonics -22.8% -7.6%
10 TREE LendingTree -21.7% -26.9%

 
Why does this matter? Significant stock moves – up or down – deserve your attention. Sharp declines in fundamentally strong names can offer smart buying opportunities. And when momentum aligns with solid fundamentals, riding the trend can be highly rewarding.

You can’t predict what happens to individual stocks, but you can prepare. See how the Trefis High Quality Portfolio helps you.

Movers – Last One Week

Analysing over the last one week (5 trading days), stocks moved decisively higher, as seen in the S&P 500 rising 0.91%, the Dow 30 rising 0.55%, and the Nasdaq 100 rising 1.49%. Most stocks saw buying, though some stocks missed out.
 
List of 1-Week Market Winners

The following table shows the list of 10 stocks that generated the highest returns over the last week:
 

# Ticker Company Name 1-W
Returns
YTD
Returns
1 BIGGQ Former BL Stores ∞% 0.0%
2 AKAN Akanda 366.8% 454.8%
3 EDSA Edesa Biotech 142.3% 1138.7%
4 RPGL Republic Power 138.7% -99.2%
5 SEGG Sports Entertainment Gaming Global 86.3% 67.1%
6 BAND Bandwidth 86.0% 190.4%
7 BRLS Borealis Foods 82.4% -17.0%
8 SOBR Sobr Safe 82.0% -54.1%
9 XRX Xerox 73.1% 16.2%
10 CUE Cue Biopharma 71.9% 232.0%

 
List of 1-Week Market Losers

Similarly, the following table shows the 10 stocks that were at the bottom in terms of returns:
 

# Ticker Company Name 1-W
Returns
YTD
Returns
1 AREB American Rebel -95.0% -100.0%
2 SNGX Soligenix -75.2% -74.3%
3 SDOT Sadot -69.1% -61.2%
4 CMPX Compass Therapeutics -61.0% -63.5%
5 LABT Lakewood-Amedex Biotherapeutics -53.3% -60.3%
6 ERAS Erasca -53.3% 169.6%
7 FCHL Fitness Champs -53.0% -97.5%
8 GLND Greenland Energy -53.0% -77.5%
9 POET POET Technologies -51.6% 15.5%
10 PMI Picard Medical -48.2% -74.9%

 
Movers – Last One Month

On a slightly wider timeline over the last one month, stocks moved decisively higher, as seen in the S&P 500 rising 9.96%, the Dow 30 rising 6.30%, and the Nasdaq 100 rising 15.36%. Most stocks saw buying, though some stocks missed out.
 
List of 1-Month Market Winners

The following table shows the 10 stocks that generated the maximum returns over the last one month:
 

# Ticker Company Name 1-M
Returns
YTD
Returns
1 JTAI Jet AI 8339.4% -94.0%
2 PSTV Plus Therapeutics 3808.9% -52.4%
3 AKAN Akanda 1725.4% 454.8%
4 MOBX Mobix Labs 733.3% -12.8%
5 NXTS Nexentis Technologies 606.4% -60.5%
6 BBGI Beasley Broadcast 505.0% 309.4%
7 CUE Cue Biopharma 400.5% 232.0%
8 XNDU Xanadu Quantum Technologies 381.6% 214.1%
9 KITT Nauticus Robotics 373.9% 207.5%
10 MXL MaxLinear 336.3% 342.8%

 
List of 1-Month Market Losers

In the same period, these 10 stocks were at the bottom in terms of returns:
 

# Ticker Company Name 1-M
Returns
YTD
Returns
1 FCHL Fitness Champs -95.9% -97.5%
2 AREB American Rebel -95.0% -100.0%
3 NMTC NeuroOne Medical Technologies -84.9% -84.1%
4 NXPL NextPlat -83.8% -88.1%
5 ELAB PMGC -82.1% -92.9%
6 ASBP Aspire Biopharma -79.0% -96.0%
7 ADTX Aditxt -78.3% -97.1%
8 PHGE BiomX -76.1% -57.8%
9 KIDZ Classover -75.9% -90.5%
10 LPCN Lipocine -74.8% -71.0%

 

Picking winners on a consistent basis is not an easy task – especially given the volatility associated with a single stock. Instead, the Trefis High Quality (HQ) Portfolio, with a collection of 30 stocks, has a track record of comfortably outperforming its benchmark that includes all 3 — the S&P 500, S&P mid-cap, and Russell 2000 indices. Why is that? As a group, HQ Portfolio stocks provided better returns with less risk versus the benchmark index; less of a roller-coaster ride, as evident in HQ Portfolio performance metrics.