Tearsheet

Cue Biopharma (CUE)


Market Price (2/18/2026): $0.292 | Market Cap: $29.5 Mil
Sector: Health Care | Industry: Biotechnology

Cue Biopharma (CUE)


Market Price (2/18/2026): $0.292
Market Cap: $29.5 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -43%
Weak multi-year price returns
2Y Excs Rtn is -125%, 3Y Excs Rtn is -159%
Penny stock
Mkt Price is 0.3
1 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -50%
  Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -38 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -537%
2 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.
  Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -26%, Rev Chg QQuarterly Revenue Change % is -36%
3   Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 80%
4   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -417%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -420%
5   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -133%
6   Key risks
CUE key risks include [1] substantial doubt about its ability to continue as a going concern due to a limited cash runway and recurring losses, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -43%
1 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -50%
2 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -125%, 3Y Excs Rtn is -159%
4 Penny stock
Mkt Price is 0.3
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -38 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -537%
6 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -26%, Rev Chg QQuarterly Revenue Change % is -36%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 80%
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -417%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -420%
9 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -133%
10 Key risks
CUE key risks include [1] substantial doubt about its ability to continue as a going concern due to a limited cash runway and recurring losses, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

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Cue Biopharma (CUE) stock has lost about 60% since 10/31/2025 because of the following key factors:

1. Significant Share Dilution from Public Offering.

Cue Biopharma announced a proposed underwritten public offering on December 18, 2025, and subsequently priced a $10 million public offering on December 19, 2025. This announcement led to a substantial 30% plunge in the stock's after-hours trading, as public offerings typically dilute the value of existing shareholders' stakes.

2. Deteriorating Financial Health and Valuation Concerns.

The company has exhibited significant financial challenges, including a reported three-year revenue growth rate of -29.9% and a current operating margin of -536.72% and net margin of -530.75%. Additionally, its projected enterprise value decreased from $432 million to $211 million, with a distressed Altman Z-Score of -18.7 indicating a high risk of bankruptcy within two years.

Show more

Stock Movement Drivers

Fundamental Drivers

The -62.1% change in CUE stock from 10/31/2025 to 2/17/2026 was primarily driven by a -53.2% change in the company's P/S Multiple.
(LTM values as of)103120252172026Change
Stock Price ($)0.770.29-62.1%
Change Contribution By: 
Total Revenues ($ Mil)87-14.3%
P/S Multiple8.84.1-53.2%
Shares Outstanding (Mil)95101-5.4%
Cumulative Contribution-62.1%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 2/17/2026
ReturnCorrelation
CUE-62.1% 
Market (SPY)0.1%15.6%
Sector (XLV)9.1%15.7%

Fundamental Drivers

The -61.2% change in CUE stock from 7/31/2025 to 2/17/2026 was primarily driven by a -40.7% change in the company's P/S Multiple.
(LTM values as of)73120252172026Change
Stock Price ($)0.750.29-61.2%
Change Contribution By: 
Total Revenues ($ Mil)87-11.2%
P/S Multiple7.04.1-40.7%
Shares Outstanding (Mil)74101-26.4%
Cumulative Contribution-61.2%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2025 to 2/17/2026
ReturnCorrelation
CUE-61.2% 
Market (SPY)8.3%18.9%
Sector (XLV)21.2%18.5%

Fundamental Drivers

The -79.9% change in CUE stock from 1/31/2025 to 2/17/2026 was primarily driven by a -49.2% change in the company's Shares Outstanding (Mil).
(LTM values as of)13120252172026Change
Stock Price ($)1.450.29-79.9%
Change Contribution By: 
Total Revenues ($ Mil)107-25.5%
P/S Multiple7.84.1-46.9%
Shares Outstanding (Mil)51101-49.2%
Cumulative Contribution-79.9%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2025 to 2/17/2026
ReturnCorrelation
CUE-79.9% 
Market (SPY)14.5%25.4%
Sector (XLV)8.6%24.9%

Fundamental Drivers

The -91.5% change in CUE stock from 1/31/2023 to 2/17/2026 was primarily driven by a -68.1% change in the company's P/S Multiple.
(LTM values as of)13120232172026Change
Stock Price ($)3.420.29-91.5%
Change Contribution By: 
Total Revenues ($ Mil)97-24.1%
P/S Multiple12.94.1-68.1%
Shares Outstanding (Mil)35101-64.9%
Cumulative Contribution-91.5%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2023 to 2/17/2026
ReturnCorrelation
CUE-91.5% 
Market (SPY)74.2%18.3%
Sector (XLV)23.5%17.0%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
CUE Return-10%-75%-7%-59%-72%0%-98%
Peers Return7%-2%-1%80%-6%3%80%
S&P 500 Return27%-19%24%23%16%-0%82%

Monthly Win Rates [3]
CUE Win Rate50%33%50%25%42%50% 
Peers Win Rate51%45%48%52%50%50% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
CUE Max Drawdown-20%-80%-40%-83%-78%-9% 
Peers Max Drawdown-17%-28%-25%-20%-36%-10% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-1% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: XNCR, JANX, AMGN, REGN, GILD. See CUE Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 2/17/2026 (YTD)

How Low Can It Go

Unique KeyEventCUES&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-90.4%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven937.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-63.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven176.3%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-74.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven296.6%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven365 days120 days

Compare to XNCR, JANX, AMGN, REGN, GILD

In The Past

Cue Biopharma's stock fell -90.4% during the 2022 Inflation Shock from a high on 11/15/2021. A -90.4% loss requires a 937.8% gain to breakeven.

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About Cue Biopharma (CUE)

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops biologic drugs for the selective modulation of the human immune system to treat a range of cancers, chronic infectious diseases, and autoimmune disorders. Its lead drug candidate is CUE-101, a fusion protein biologic that is in Phase 1b clinical trial designed to target and activate antigen-specific T cells for human papilloma virus-driven cancers. The company offers CUE-102, a fusion protein biologic to target and activate antigen-specific T cells to fight cancers; CUE-103 a CUE-100 series Immuno-STAT targeting the KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer; CUE-200 that focuses on cell surface receptors, including CD80 and/or 4-1BBL to address T cell exhaustion associated with chronic infections; and CUE-300 and CUE-400 framework to target various autoimmune diseases. Cue Biopharma, Inc. has collaboration agreements with Merck Sharp & Dohme Corp. for the research and development of its proprietary biologics that target various autoimmune disease indications; LG Chem Life Sciences for the development of Immuno-STATs focused on the field of oncology; and Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.

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  • A next-generation Merck (Keytruda) or Bristol Myers Squibb (Opdivo), focused on developing highly precise immunotherapies that 'train' specific immune cells to fight cancer and autoimmune diseases.
  • Like a CRISPR Therapeutics or Editas Medicine, but instead of editing genes, they are precisely engineering specific immune cells (T-cells) to treat diseases.
  • An early-stage Amgen or Gilead Sciences focused on a unique platform to develop 'smart' biologic drugs that selectively activate or de-activate key immune cells for therapeutic benefit.

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  • CUE-101: A novel, T cell-selective IL-2-based biologic currently in clinical trials for the treatment of HPV-driven cancers.
  • CUE-102: An investigational T cell-selective IL-2-based biologic in preclinical development, designed to target specific tumor antigens for various cancers.
  • CUE-300 Series: A pipeline of preclinical biologics being developed to modulate T cell activity for the treatment of autoimmune diseases.

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Cue Biopharma (CUE) is a clinical-stage biotechnology company that sells primarily to other companies through collaboration and licensing agreements. It does not sell products directly to individuals.

Its major customers and partners, which provide revenue through research funding, milestone payments, and potential royalties, include:

  • Merck KGaA, Darmstadt, Germany: A leading science and technology company operating in healthcare, life science, and electronics. It is important to note that this is a private German company and is distinct from Merck & Co., Inc. (MRK) in the United States.
  • LG Chem Life Sciences: This is the life sciences division of LG Chem Ltd., a diversified South Korean chemical company. LG Chem Ltd.'s stock symbol is KRX: 051910 on the Korea Exchange.

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Goodwin Biotechnology, Inc.

Sanofi S.A. (SNY)

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Usman “Oz” Azam, M.D. President and Chief Executive Officer

Dr. Azam was appointed President and Chief Executive Officer of Cue Biopharma effective September 29, 2025. He brings over 25 years of leadership experience in drug discovery and development. Most recently, Dr. Azam served as CEO of Inspirna, Inc., a privately held clinical-stage biopharmaceutical company focused on cancer drugs. Prior to Inspirna, he was CEO of Empyrean Neuroscience, a genetic engineering company. As President and CEO of Tmunity Therapeutics, he was involved in developing genetically engineered CAR-T cell therapies. He also served as Global Head of the Cell and Gene Therapies unit at Novartis, where he played a role in the launch of the first FDA-approved CAR-T cell therapy. Dr. Azam has held leadership positions at Pfizer Pharmaceuticals, Aspreva Pharmaceuticals, Johnson & Johnson, and GlaxoSmithKline (GSK).

Currently, Cue Biopharma's official leadership page does not list a Chief Financial Officer. Kerri-Ann Millar, the former CFO, resigned effective June 13, 2025. Daniel Passeri, who was CEO at the time, stepped in as interim Principal Financial and Accounting Officer until a permanent successor could be found. On September 29, 2025, Mr. Passeri transitioned from CEO to Strategic Advisor.

Lucinda Warren Chief Business Officer

Ms. Warren was appointed Chief Business Officer of Cue Biopharma on September 9, 2024. She possesses over 30 years of global experience in the pharmaceutical and biotechnology sectors. Before joining Cue Biopharma, she served as Vice President of Business Development for Neuroscience and Japan Regionally at Johnson & Johnson from 2014 to 2024. In this role, she was responsible for comprehensive business development activities, including licensing, mergers and acquisitions, and alliance management. Her experience also includes significant leadership roles at Janssen Cilag Australia and Centocor/Janssen Biologics.

Matteo Levisetti, M.D. Chief Medical Officer

Dr. Levisetti brings extensive experience in leading global clinical development for pharmaceutical companies of various sizes. Prior to Cue Biopharma, he held the position of Chief Medical Officer at DNAtrix, where he managed clinical operations and regulatory strategy for multiple clinical trials. He also served as Chief Medical Officer at Dauntless Pharmaceuticals and directed immuno-oncology programs as Executive Director of Clinical Development at Mirati Therapeutics. His career includes senior positions with Pfizer, such as Global Clinical Lead, and Global Head & Vice President, Translational Medicine, Immunology and Inflammation at Roche Pharma Research & Early Development.

Daniel Baker, M.D. Interim Chief Development Officer

Dr. Baker serves as the Interim Chief Development Officer at Cue Biopharma.

Colin Sandercock, M.S.E., J.D. Senior Vice President and General Counsel

Mr. Sandercock holds the roles of Senior Vice President and General Counsel at Cue Biopharma.

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Key Risks to Cue Biopharma (CUE)

Cue Biopharma (CUE) faces several significant risks to its business, primarily stemming from its financial viability, compliance with listing requirements, and the inherent challenges of being a clinical-stage biotechnology company.

  1. Substantial Doubt About Going Concern: The most significant risk to Cue Biopharma is the substantial doubt about its ability to continue as a going concern. The company has a history of recurring losses and negative cash flows, with a projected cash runway of less than one year based on current financial data. This financial instability, highlighted by an Altman Z-Score indicating a potential risk of bankruptcy within the next two years, necessitates the company seeking additional capital to fund its operations.
  2. Nasdaq Listing Non-Compliance: Cue Biopharma has encountered challenges in maintaining compliance with Nasdaq's continued listing requirements, particularly the minimum bid price rule. While the company has recently regained compliance after receiving a deficiency letter, the potential for future non-compliance remains a significant concern. Any delisting could severely impact the stock's market liquidity, diminish the company's ability to secure favorable capital terms, and erode stakeholder confidence.
  3. Clinical Trial and Regulatory Risks / Dependence on Pipeline Success: As a clinical-stage biotechnology company, Cue Biopharma has not yet generated revenue from product sales and is entirely dependent on the successful development and eventual commercialization of its drug candidates. With only a limited number of drug candidates in clinical trials, setbacks such as negative or inconclusive trial results, delays in regulatory approvals from the U.S. Food and Drug Administration (FDA), or unexpected drug-related side effects, would have a material adverse impact on the company's prospects and financial stability.

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Cue Biopharma (CUE) is a clinical-stage biopharmaceutical company, and its future revenue growth over the next 2-3 years is primarily anticipated to be driven by strategic collaborations and the advancement of its therapeutic pipeline. Here are 4 expected drivers of future revenue growth for Cue Biopharma:
  1. Growth in Collaboration Revenue through Upfront Payments and Milestone Achievements: Cue Biopharma has demonstrated a strategy of securing partnerships, which has already led to increased collaboration revenue. The company’s collaboration with Ono Pharmaceutical, established in February 2023, has contributed to this growth. More recently, a partnership with Boehringer Ingelheim concerning CUE-501 included a $12 million upfront payment in Q2 2025 and holds potential for up to $345 million in milestone payments. Additionally, a collaboration with ImmunoScape announced in November 2025 is expected to provide $15 million in upfront payments ($10 million in Q4 2025 and $5 million in November 2026), alongside a 40% equity stake in ImmunoScape and eligibility for high-single-digit royalty payments on net sales. Continued achievement of milestones in these existing collaborations and the formation of new strategic partnerships will be a significant revenue driver.
  2. Advancement of the Autoimmune Disease Pipeline: Cue Biopharma has strategically refocused its efforts on its autoimmune programs, particularly CUE-401 and the CUE-500 series. CUE-401, developed in collaboration with Ono Pharmaceutical, is progressing with the anticipation of lead candidate selection in Q1 2025 and an intention to advance an Investigational New Drug (IND) submission following positive FDA feedback. The CUE-500 series is being positioned for strategic partnering to address B-cell-mediated autoimmune diseases. Successful progression of these candidates through preclinical and early clinical stages is expected to trigger further collaboration and milestone payments.
  3. Strategic Partnering for Oncology Programs: While Cue Biopharma has downsized its direct investment in oncology programs to focus on autoimmune diseases, it intends to preserve the potential value of its clinical oncology programs, CUE-101 and CUE-102, by pursuing partnerships. CUE-101 has shown promising clinical activity in Phase 1 trials for HPV+ recurrent/metastatic head and neck squamous cell carcinoma, both as a monotherapy and in combination with KEYTRUDA®. Securing new out-licensing or co-development agreements for these oncology assets would generate upfront payments, milestone payments, and potential future royalties.
  4. Expansion and Diversification of the Immuno-STAT Platform into New Indications: The company's proprietary Immuno-STAT™ platform is described as modular and versatile, designed to selectively engage and modulate targeted T cells for a broad range of indications beyond oncology, including autoimmune and infectious diseases. This inherent flexibility of the platform creates opportunities for Cue Biopharma to discover and develop new therapeutic candidates and enter into additional collaborations across various therapeutic areas, further diversifying its potential revenue streams.

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Share Issuance

  • In April 2025, Cue Biopharma raised approximately $20 million in gross proceeds through a public offering of common stock and accompanying warrants, including pre-funded warrants.
  • As of September 30, 2024, the company had sold 9,028,573 shares of common stock under an At-The-Market (ATM) agreement initiated in October 2021, yielding $40.4 million in net proceeds.
  • In November 2022, Cue Biopharma completed a Post IPO funding round for $30 million.

Inbound Investments

  • In April 2025, Cue Biopharma entered a strategic collaboration and license agreement with Boehringer Ingelheim for its CUE-501 candidate, receiving a $12 million upfront payment and eligible for up to approximately $345 million in potential milestone payments.
  • In November 2025, Cue Biopharma announced a strategic collaboration with ImmunoScape, entitling Cue Biopharma to an upfront payment of $15 million ($10 million in Q4 2025 and $5 million in November 2026), a 40% equity stake in ImmunoScape, and high-single-digit royalties on net sales.

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BIIB_1162026_Dip_Buyer_FCFYield01162026BIIBBiogenDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
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DOCS_1162026_Dip_Buyer_High_CFO_Margins_ExInd_DE01162026DOCSDoximityDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Mkt Price0.2911.5413.21373.36793.53155.2784.24
Mkt Cap0.00.90.8200.981.8193.041.3
Rev LTM71501036,75114,34329,0867,247
Op Inc LTM-38-137-1449,0803,70211,1511,832
FCF LTM-30-138-718,1003,7659,1621,868
FCF 3Y Avg-36-144-558,6183,6578,8151,811
CFO LTM-30-133-709,9584,9799,6672,475
CFO 3Y Avg-36-129-539,9734,6649,3642,314

Growth & Margins

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Rev Chg LTM-25.5%38.2%-23.4%10.0%1.0%2.8%1.9%
Rev Chg 3Y Avg21.6%-12.7%15.1%11.9%5.7%2.3%8.8%
Rev Chg Q-35.6%18.0%2,177.9%8.6%2.5%3.0%5.8%
QoQ Delta Rev Chg LTM-14.3%2.2%2,177.9%2.2%0.7%0.8%1.5%
Op Mgn LTM-536.7%-91.3%-1,442.9%24.7%25.8%38.3%-33.3%
Op Mgn 3Y Avg-802.7%-123.4%-996.2%24.8%29.0%39.2%-49.3%
QoQ Delta Op Mgn LTM-60.4%7.2%31,559.2%0.6%-0.9%0.9%0.8%
CFO/Rev LTM-417.5%-88.8%-704.2%27.1%34.7%33.2%-30.8%
CFO/Rev 3Y Avg-617.8%-98.4%-536.2%30.5%33.6%33.1%-33.9%
FCF/Rev LTM-420.0%-91.9%-714.0%22.0%26.3%31.5%-34.9%
FCF/Rev 3Y Avg-618.8%-109.0%-555.0%26.4%26.4%31.2%-41.3%

Valuation

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Mkt Cap0.00.90.8200.981.8193.041.3
P/S4.15.781.95.55.76.65.7
P/EBIT-0.8-8.9-5.717.115.517.77.4
P/E-0.8-6.6-8.026.018.223.88.7
P/CFO-1.0-6.4-11.620.216.420.07.7
Total Yield-128.8%-15.2%-12.4%6.4%6.0%6.3%-3.2%
Dividend Yield0.0%0.0%0.0%2.6%0.5%2.1%0.2%
FCF Yield 3Y Avg-65.9%-11.2%-7.0%5.6%4.4%7.3%-1.3%
D/E0.20.10.00.30.00.10.1
Net D/E-0.4-0.5-1.20.2-0.10.1-0.2

Returns

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
1M Rtn-3.6%-9.8%-4.0%13.8%8.3%24.3%2.3%
3M Rtn-49.8%-28.0%-54.5%10.1%9.4%22.9%-9.3%
6M Rtn-64.3%52.0%-46.5%29.1%39.0%33.4%31.3%
12M Rtn-80.5%-29.2%-63.7%32.3%18.5%53.4%-5.4%
3Y Rtn-90.8%-67.4%-25.2%70.5%6.6%103.6%-9.3%
1M Excs Rtn6.5%-11.2%-2.3%15.4%8.4%29.5%7.5%
3M Excs Rtn-54.6%-19.1%-53.5%11.1%12.6%23.3%-4.0%
6M Excs Rtn-70.9%44.2%-53.5%22.6%31.0%26.9%24.8%
12M Excs Rtn-91.4%-41.1%-76.4%18.8%6.4%38.7%-17.3%
3Y Excs Rtn-159.3%-135.8%-93.7%4.7%-60.5%34.1%-77.1%

Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Developing a novel class of therapeutic biologics to selectively modulate disease-specific T cells511533
Total511533


Price Behavior

Price Behavior
Market Price$0.29 
Market Cap ($ Bil)0.0 
First Trading Date01/02/2018 
Distance from 52W High-80.5% 
   50 Days200 Days
DMA Price$0.36$0.64
DMA Trenddowndown
Distance from DMA-19.1%-54.6%
 3M1YR
Volatility139.3%96.6%
Downside Capture258.43189.94
Upside Capture-177.67-1.88
Correlation (SPY)14.0%24.9%
CUE Betas & Captures as of 1/31/2026

 1M2M3M6M1Y3Y
Beta3.560.811.751.761.251.25
Up Beta18.016.113.872.811.201.61
Down Beta0.913.324.014.271.802.07
Up Capture228%-376%-193%-64%-1%1%
Bmk +ve Days11223471142430
Stock +ve Days9132355109322
Down Capture60%123%221%146%132%103%
Bmk -ve Days9192754109321
Stock -ve Days11283869138413

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-79.9%96.8%-1.23-
Sector ETF (XLV)9.0%17.4%0.3424.8%
Equity (SPY)13.0%19.4%0.5125.1%
Gold (GLD)67.2%25.5%1.9913.0%
Commodities (DBC)5.2%16.8%0.1317.3%
Real Estate (VNQ)7.8%16.6%0.2824.3%
Bitcoin (BTCUSD)-28.8%44.9%-0.6216.4%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-55.2%96.2%-0.41-
Sector ETF (XLV)7.9%14.5%0.3618.6%
Equity (SPY)13.3%17.0%0.6224.1%
Gold (GLD)21.3%17.1%1.026.9%
Commodities (DBC)10.2%18.9%0.429.4%
Real Estate (VNQ)5.3%18.8%0.1918.5%
Bitcoin (BTCUSD)8.2%57.2%0.3613.9%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-30.9%88.4%-0.12-
Sector ETF (XLV)11.3%16.5%0.5722.9%
Equity (SPY)15.8%17.9%0.7626.8%
Gold (GLD)14.8%15.6%0.797.8%
Commodities (DBC)8.0%17.6%0.3712.9%
Real Estate (VNQ)6.8%20.7%0.2919.7%
Bitcoin (BTCUSD)68.5%66.7%1.0814.6%

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Short Interest

Short Interest: As Of Date1302026
Short Interest: Shares Quantity2.2 Mil
Short Interest: % Change Since 115202616.8%
Average Daily Volume2.1 Mil
Days-to-Cover Short Interest1.0 days
Basic Shares Quantity100.9 Mil
Short % of Basic Shares2.1%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/12/2025-7.2%-13.1%-30.7%
8/12/20252.6%3.3%-3.1%
3/31/2025-17.7%-31.3%-17.1%
5/9/2024-9.1%-9.1%-24.8%
3/17/2020-13.7%22.7%63.3%
SUMMARY STATS   
# Positive121
# Negative434
Median Positive2.6%13.0%63.3%
Median Negative-11.4%-13.1%-21.0%
Max Positive2.6%22.7%63.3%
Max Negative-17.7%-31.3%-30.7%

SEC Filings

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Report DateFiling DateFiling
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/12/202510-Q
12/31/202403/31/202510-K
09/30/202411/14/202410-Q
06/30/202408/14/202410-Q
03/31/202405/09/202410-Q
12/31/202303/28/202410-K
09/30/202311/03/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202203/21/202310-K
09/30/202211/14/202210-Q
06/30/202208/04/202210-Q
03/31/202205/10/202210-Q
12/31/202103/16/202210-K

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Sarraf, Pasha DirectBuy10220260.31323,85799,74799,747Form