Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -42%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 196%

Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -81%

Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -104%, 3Y Excs Rtn is -151%

Penny stock
Mkt Price is 0.5

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -27 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -97%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 17%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -79%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -80%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53%

High stock price volatility
Vol 12M is 129%

Key risks
CUE key risks include [1] substantial doubt about its ability to continue as a going concern due to a limited cash runway and recurring losses, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -42%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 196%
2 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -81%
3 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.
4 Weak multi-year price returns
2Y Excs Rtn is -104%, 3Y Excs Rtn is -151%
5 Penny stock
Mkt Price is 0.5
6 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -27 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -97%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 17%
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -79%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -80%
9 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -53%
10 High stock price volatility
Vol 12M is 129%
11 Key risks
CUE key risks include [1] substantial doubt about its ability to continue as a going concern due to a limited cash runway and recurring losses, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Cue Biopharma (CUE) stock has gained about 65% since 12/31/2025 because of the following key factors:

1. Achievement of a $7.5 million preclinical milestone payment from Boehringer Ingelheim.

Cue Biopharma announced on April 8, 2026, that it would receive a $7.5 million payment from its collaboration and license agreement with Boehringer Ingelheim. This milestone was triggered by Boehringer Ingelheim's selection and approval of the first compound, CUE-501, for lead optimization in the development of treatments for autoimmune and inflammatory diseases. The payment is anticipated in May 2026, and the agreement includes potential for up to an additional $337.5 million in future milestone payments and royalties.

2. Positive preclinical data and advancement of lead autoimmune asset, CUE-401, towards clinical trials.

In February 2026, Cue Biopharma announced supportive preclinical safety and tolerability data for its lead autoimmune asset, CUE-401, highlighting that the compound was well-tolerated with no observed adverse events in two non-GLP studies. Further reinforcing its potential, new in vitro data for CUE-401 were presented at the World Immune Regulation Meeting in March 2026. The company is targeting an Investigational New Drug (IND) filing for CUE-401 in the second quarter of 2026.

Show more

Stock Movement Drivers

Fundamental Drivers

The 64.3% change in CUE stock from 12/31/2025 to 4/10/2026 was primarily driven by a 286.8% change in the company's Total Revenues ($ Mil).
(LTM values as of)123120254102026Change
Stock Price ($)0.310.5064.3%
Change Contribution By: 
Total Revenues ($ Mil)727286.8%
P/S Multiple4.32.0-54.5%
Shares Outstanding (Mil)101108-6.7%
Cumulative Contribution64.3%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/10/2026
ReturnCorrelation
CUE64.3% 
Market (SPY)-5.4%24.6%
Sector (XLV)-4.8%10.1%

Fundamental Drivers

The -30.2% change in CUE stock from 9/30/2025 to 4/10/2026 was primarily driven by a -76.1% change in the company's P/S Multiple.
(LTM values as of)93020254102026Change
Stock Price ($)0.720.50-30.2%
Change Contribution By: 
Total Revenues ($ Mil)827231.4%
P/S Multiple8.32.0-76.1%
Shares Outstanding (Mil)95108-11.7%
Cumulative Contribution-30.2%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/10/2026
ReturnCorrelation
CUE-30.2% 
Market (SPY)-2.9%20.9%
Sector (XLV)6.3%11.9%

Fundamental Drivers

The -44.9% change in CUE stock from 3/31/2025 to 4/10/2026 was primarily driven by a -72.9% change in the company's P/S Multiple.
(LTM values as of)33120254102026Change
Stock Price ($)0.910.50-44.9%
Change Contribution By: 
Total Revenues ($ Mil)927195.7%
P/S Multiple7.32.0-72.9%
Shares Outstanding (Mil)74108-31.2%
Cumulative Contribution-44.9%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2025 to 4/10/2026
ReturnCorrelation
CUE-44.9% 
Market (SPY)16.3%23.2%
Sector (XLV)2.3%18.9%

Fundamental Drivers

The -85.9% change in CUE stock from 3/31/2023 to 4/10/2026 was primarily driven by a -98.2% change in the company's P/S Multiple.
(LTM values as of)33120234102026Change
Stock Price ($)3.570.50-85.9%
Change Contribution By: 
Total Revenues ($ Mil)1272106.1%
P/S Multiple112.42.0-98.2%
Shares Outstanding (Mil)39108-63.8%
Cumulative Contribution-85.9%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2023 to 4/10/2026
ReturnCorrelation
CUE-85.9% 
Market (SPY)63.3%18.0%
Sector (XLV)19.1%15.1%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
CUE Return-10%-75%-7%-59%-72%-4%-98%
Peers Return7%-2%-1%80%-6%3%79%
S&P 500 Return27%-19%24%23%16%-0%82%

Monthly Win Rates [3]
CUE Win Rate50%33%50%25%42%50% 
Peers Win Rate51%45%48%52%50%55% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
CUE Max Drawdown-20%-80%-40%-83%-78%-42% 
Peers Max Drawdown-17%-28%-25%-20%-36%-10% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: XNCR, JANX, AMGN, REGN, GILD. See CUE Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/10/2026 (YTD)

How Low Can It Go

Unique KeyEventCUES&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-90.4%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven937.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-63.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven176.3%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-74.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven296.6%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven365 days120 days

Compare to XNCR, JANX, AMGN, REGN, GILD

In The Past

Cue Biopharma's stock fell -90.4% during the 2022 Inflation Shock from a high on 11/15/2021. A -90.4% loss requires a 937.8% gain to breakeven.

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About Cue Biopharma (CUE)

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, develops biologic drugs for the selective modulation of the human immune system to treat a range of cancers, chronic infectious diseases, and autoimmune disorders. Its lead drug candidate is CUE-101, a fusion protein biologic that is in Phase 1b clinical trial designed to target and activate antigen-specific T cells for human papilloma virus-driven cancers. The company offers CUE-102, a fusion protein biologic to target and activate antigen-specific T cells to fight cancers; CUE-103 a CUE-100 series Immuno-STAT targeting the KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer; CUE-200 that focuses on cell surface receptors, including CD80 and/or 4-1BBL to address T cell exhaustion associated with chronic infections; and CUE-300 and CUE-400 framework to target various autoimmune diseases. Cue Biopharma, Inc. has collaboration agreements with Merck Sharp & Dohme Corp. for the research and development of its proprietary biologics that target various autoimmune disease indications; LG Chem Life Sciences for the development of Immuno-STATs focused on the field of oncology; and Albert Einstein College of Medicine. The company was formerly known as Imagen Biopharma, Inc. and changed its name to Cue Biopharma, Inc. in October 2016. Cue Biopharma, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.

AI Analysis | Feedback

Imagine a "precision immunotherapy lab" focused on designing smart biologic drugs to specifically activate your immune system's T-cells to fight diseases. Cue Biopharma is building this next generation of targeted immune therapies, much like a specialized, early-stage Genentech or Amgen.

Think of Cue Biopharma as a company developing highly specific "on-switches" for your immune system. They're creating novel biologic drugs to precisely instruct T-cells to attack cancers and other serious illnesses, similar to how a more targeted Merck might evolve its immunotherapy approach beyond broad checkpoint inhibitors.

AI Analysis | Feedback

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  • CUE-101: A fusion protein biologic in Phase 1b clinical trial designed to activate T cells for human papilloma virus-driven cancers.
  • CUE-102: A fusion protein biologic designed to target and activate antigen-specific T cells to fight cancers.
  • CUE-103: A CUE-100 series Immuno-STAT targeting the KRAS G12V mutation for various cancers including colorectal, lung, and pancreatic.
  • CUE-200: A drug framework that focuses on cell surface receptors to address T cell exhaustion associated with chronic infections.
  • CUE-300 framework: A drug framework developed to target various autoimmune diseases.
  • CUE-400 framework: A drug framework developed to target various autoimmune diseases.
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AI Analysis | Feedback

Cue Biopharma (CUE) is a clinical-stage biopharmaceutical company focused on the research and development of biologic drugs. As such, it does not currently sell drugs directly to individuals or through traditional distribution channels. Its revenue primarily stems from collaboration agreements and partnerships with other companies and research institutions.

Based on the provided information, Cue Biopharma's major customers and partners include:

  • Merck Sharp & Dohme Corp. (Symbol: MRK)
  • LG Chem Life Sciences (part of LG Chem, Symbol: 051910.KS)
  • Albert Einstein College of Medicine

AI Analysis | Feedback

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Usman “Oz” Azam, M.D. President and Chief Executive Officer

Dr. Azam brings over 25 years of leadership experience in drug discovery, development, and operations to Cue Biopharma. He previously served as Chief Executive Officer of Inspirna, Inc., a privately held clinical-stage biopharmaceutical company, and Empyrean Neuroscience, a genetic engineering company. He was also the President and CEO of Tmunity Therapeutics, which developed genetically engineered CAR-T cell therapies. Prior to these roles, Dr. Azam was the Global Head of the Cell and Gene Therapies unit at Novartis, where he played a key role in the launch of the first-ever FDA-approved CAR-T cell therapy. His career also includes leadership positions at Pfizer Pharmaceuticals, Aspreva Pharmaceuticals, Johnson & Johnson, and GlaxoSmithKline (GSK).

Lucinda Warren Chief Financial Officer and Business Officer

Ms. Warren has over 30 years of global experience in the pharmaceutical and biotechnology sectors. Before joining Cue Biopharma, she was the Vice President of Business Development for Neuroscience and Japan Regionally at Johnson & Johnson from 2014 to 2024. In this role, she was responsible for end-to-end business development, including licensing, mergers and acquisitions, and alliance management. Ms. Warren has also held leadership positions at Janssen Cilag Australia and Janssen Biologics.

Anish Suri, Ph.D. Chief Scientific Officer

Dr. Suri serves as the President and Chief Scientific Officer at Cue Biopharma Inc. He previously held the position of Senior Vice President and Chief Scientific Officer at the company and served as an Assistant Professor of Pathology & Immunology at Washington University.

Colin Sandercock, M.S.E., J.D. Senior Vice President and General Counsel

Mr. Sandercock has over 30 years of experience providing legal counsel to life sciences companies on a wide range of matters, including domestic and international patent litigation, compliance, procurement, and licensing. Before joining Cue Biopharma, he was a Partner at Perkins Coie, a position he held since 2009.

Daniel Baker, M.D. Interim Chief Development Officer

Dr. Baker is the Interim Chief Development Officer at Cue Biopharma.

AI Analysis | Feedback

Here are the key risks to Cue Biopharma's business:

  1. Financial Health and Going Concern: Cue Biopharma is a clinical-stage biopharmaceutical company with a history of significant operating losses and negative cash flows, and it has not yet generated commercial revenue from product sales. The company's recurring losses raise substantial doubt about its ability to continue as a going concern, as indicated by its Altman Z-Score which places it in a distress zone. Its survival is heavily dependent on its ability to secure consistent, non-dilutive funding, often through strategic partnerships or future capital raises, to cover its significant research and development expenses and sustain operations.
  2. Clinical Trial and Regulatory Risk: The success of Cue Biopharma is fundamentally reliant on the successful development, clinical testing, and regulatory approval of its drug candidates, such as CUE-101 and CUE-401. As a company with only a few drug candidates currently in clinical trials, any setbacks, delays, or failures in these trials, or an inability to obtain necessary regulatory approvals from agencies like the FDA, would have a material adverse impact on its business, financial condition, and future growth prospects.
  3. Dependence on Collaborations and External Funding: Cue Biopharma's revenue stream is primarily derived from collaboration agreements with third parties, rather than product sales. The continuation and success of these partnerships are critical, as the company depends on upfront payments and milestone recognition from these agreements to fund its operations and pipeline development. The termination or reduction of any key collaboration agreements could significantly impact its financial stability and ability to advance its drug candidates.

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Cue Biopharma's main products target several significant addressable markets globally:

  • CUE-101 (targeting Human Papillomavirus (HPV)-driven cancers, specifically HPV16-positive Head and Neck Squamous Cell Carcinoma (HNSCC)): The global HPV associated disorders treatment market was valued at USD 19.6 billion in 2023 and is projected to grow to USD 30.1 billion by 2032. More specifically, the HPV16-positive HNSCC market was approximately USD 810 million in 2024 across the 7MM (United States, EU4: Germany, France, Italy, Spain, United Kingdom, and Japan). Additionally, the global cervical cancer treatment market is projected to grow from an estimated US$8.6 billion in 2024 to US$11.8 billion by 2030.
  • CUE-103 (targeting KRAS G12V mutation, including colorectal carcinoma, lung cancer, and pancreatic cancer):
    • Colorectal Cancer: The global colorectal cancer market size was evaluated at USD 13 billion in 2023 and is slated to reach USD 20 billion by the end of 2032. The global metastatic colorectal cancer market is projected to reach USD 19.06 billion by 2035, from USD 6.78 billion in 2024.
    • Lung Cancer: The global lung cancer market is estimated to be valued at USD 31.72 billion in 2026 and is expected to reach USD 73.70 billion by 2033.
    • Pancreatic Cancer: The global pancreatic cancer treatment market size was estimated at USD 2.92 billion in 2024 and is projected to reach USD 5.84 billion by 2030. Another estimate indicates the global pancreatic cancer industry will increase from USD 2.65 billion in 2024 to USD 9.57 billion by 2034.
  • CUE-200 (focusing on T cell exhaustion associated with chronic infections): The global infectious disease therapeutics market size was estimated at USD 243,409.1 million in 2024 and is projected to reach USD 283,908.2 million by 2030.
  • CUE-300 and CUE-400 (targeting various autoimmune diseases): The global autoimmune disease therapeutics market size was worth around USD 123.96 billion in 2024 and is predicted to grow to around USD 249.71 billion by 2034.

AI Analysis | Feedback

Here are 3-5 expected drivers of future revenue growth for Cue Biopharma (CUE) over the next 2-3 years:

  1. Milestone and Upfront Payments from Strategic Collaborations: Cue Biopharma's revenue primarily stems from collaboration agreements as it is a clinical-stage biopharmaceutical company without commercial product sales. Significant drivers include upfront payments and potential milestone payments from existing and future partnerships. For instance, the company has a collaboration and license agreement with Boehringer Ingelheim for CUE-501, which included an upfront payment of $12 million in April 2025 and potential milestone payments totaling approximately $345 million. Another strategic collaboration with ImmunoScape, announced in November 2025, provides for $15 million in upfront payments ($10 million in Q4 2025 and $5 million in November 2026) and a 40% equity stake in ImmunoScape. The successful execution of these agreements and the initiation of new collaborations for its Immuno-STAT platform, especially in the autoimmune space, are critical for revenue growth.
  2. Advancement of Clinical Pipeline Candidates: Progress in the clinical development of its lead drug candidates is a key driver for future revenue. CUE-101, a fusion protein biologic in Phase 1b clinical trials for HPV-driven cancers, has shown promising clinical data, including a confirmed 50% Overall Response Rate (ORR) in combination with pembrolizumab and a median Overall Survival (mOS) of 32.7 months. Further advancement of CUE-101 towards later-stage trials and potential regulatory approval, as well as the progression of other oncology candidates like CUE-102 and CUE-103, could lead to increased partnership interest or eventual commercialization revenue.
  3. Development of Autoimmune Disease Programs: Cue Biopharma has strategically pivoted to prioritize its autoimmune disease programs, with CUE-401 being a lead candidate aiming to address high unmet medical needs. Advancing CUE-401 towards clinical trials is a significant focus, and promising preclinical data for CUE-401 was presented in March 2026. The company's CUE-500 series, including CUE-501, also targets autoimmune and inflammatory diseases and is part of the Boehringer Ingelheim collaboration. Successful development and potential partnering of these autoimmune assets represent a substantial long-term revenue opportunity.
  4. Potential Royalty Streams from Commercialized Products: While not expected in the immediate 2-3 years given the clinical-stage nature of its pipeline, the long-term revenue growth could be driven by royalty payments on net sales if any of its partnered drug candidates, such as CUE-501 or products developed through the ImmunoScape collaboration, successfully reach commercialization.

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Share Issuance

Cue Biopharma priced an underwritten public offering in December 2025 to raise approximately $10 million in gross proceeds through the sale of common stock and accompanying warrants. In September 2024, the company priced another underwritten public offering, generating approximately $12.0 million in gross proceeds from common stock and warrants. An underwritten public offering in April 2025 aimed to raise approximately $20 million in gross proceeds, also through common stock and warrants. Additionally, in November 2022, Cue Biopharma secured $30 million from a private investment in public equity (PIPE) financing, involving the sale of common stock and pre-funded warrants with accompanying warrants.

Inbound Investments

In November 2025, Cue Biopharma entered into a strategic collaboration and license agreement with ImmunoScape, which includes an upfront payment of $15 million ($10 million in Q4 2025 and $5 million in November 2026) and a 40% equity stake in ImmunoScape. Earlier in April 2025, the company announced a strategic research collaboration and license agreement with Boehringer Ingelheim for CUE-501, which provided an upfront payment of $12 million and ongoing research support payments. A $30 million private investment in public equity (PIPE) financing from accredited investors, including a new life sciences-focused investment fund, was completed in November 2022.

Outbound Investments

As part of its strategic collaboration and license agreement with ImmunoScape in November 2025, Cue Biopharma is entitled to a 40% equity stake in ImmunoScape.

Capital Expenditures

Cue Biopharma invested $66K in capital expenditures during fiscal year 2024, which was utilized to fund long-term assets and infrastructure.

Better Bets vs. Cue Biopharma (CUE)

Trade Ideas

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Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
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2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
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-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Mkt Price0.5012.4214.93351.02748.87138.9976.96
Mkt Cap0.10.90.9188.877.2172.539.1
Rev LTM271261036,75114,34329,4417,234
Op Inc LTM-27-178-1589,0803,70211,6991,838
FCF LTM-22-138-838,1003,7659,4561,872
FCF 3Y Avg-33-150-608,6183,6579,0611,812
CFO LTM-22-135-829,9584,97910,0192,479
CFO 3Y Avg-33-138-599,9734,6649,6182,316

Growth & Margins

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Rev Chg LTM195.7%13.7%-5.6%10.0%1.0%2.4%6.2%
Rev Chg 3Y Avg202.0%-5.7%6.4%11.9%5.7%2.6%6.1%
Rev Chg Q1,292.3%-46.5%-8.6%2.5%4.7%4.7%
QoQ Delta Rev Chg LTM286.8%-16.4%0.0%2.2%0.7%1.2%0.9%
Op Mgn LTM-96.6%-141.4%-1,576.7%24.7%25.8%39.7%-35.9%
Op Mgn 3Y Avg-497.1%-126.2%-1,137.7%24.8%29.0%36.4%-50.7%
QoQ Delta Op Mgn LTM440.2%-50.1%-133.8%0.6%-0.9%1.1%-0.2%
CFO/Rev LTM-79.0%-107.6%-822.3%27.1%34.7%34.0%-25.9%
CFO/Rev 3Y Avg-399.3%-111.7%-620.6%30.5%33.6%33.7%-40.6%
FCF/Rev LTM-79.6%-110.1%-832.8%22.0%26.3%32.1%-28.8%
FCF/Rev 3Y Avg-399.8%-119.5%-632.9%26.4%26.4%31.8%-46.6%

Valuation

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
Mkt Cap0.10.90.9188.877.2172.539.1
P/S2.07.492.85.15.45.95.6
P/EBIT-2.1-16.1-5.916.114.615.96.3
P/E-2.0-10.1-8.224.517.120.37.6
P/CFO-2.5-6.9-11.319.015.517.26.5
Total Yield-49.2%-9.9%-12.2%6.8%6.3%7.3%-1.8%
Dividend Yield0.0%0.0%0.0%2.7%0.5%2.3%0.2%
FCF Yield 3Y Avg-47.7%-10.8%-7.2%5.6%4.4%7.5%-1.4%
D/E0.10.20.00.30.00.10.1
Net D/E-0.4-0.4-1.00.2-0.10.1-0.2

Returns

CUEXNCRJANXAMGNREGNGILDMedian
NameCue Biop.Xencor Janux Th.Amgen Regenero.Gilead S. 
1M Rtn54.5%3.2%6.0%-7.0%-3.3%-4.8%-0.1%
3M Rtn39.2%-10.6%5.4%8.4%-5.9%15.4%6.9%
6M Rtn-36.9%-4.7%-43.7%22.7%33.0%20.1%7.7%
12M Rtn-30.2%56.8%-44.4%28.6%37.8%40.7%33.2%
3Y Rtn-83.9%-56.5%7.3%53.4%-8.0%86.4%-0.3%
1M Excs Rtn53.9%2.5%5.4%-7.7%-3.9%-5.4%-0.7%
3M Excs Rtn29.3%-11.0%8.8%8.6%-4.9%17.3%8.7%
6M Excs Rtn-42.4%-0.8%-39.2%19.9%32.2%18.1%8.6%
12M Excs Rtn-55.6%25.1%-74.1%-7.6%-1.6%1.5%-4.6%
3Y Excs Rtn-151.4%-121.6%-38.2%-10.5%-74.5%21.1%-56.4%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Developing a novel class of therapeutic biologics to selectively modulate disease-specific T cells951153
Total951153


Price Behavior

Price Behavior
Market Price$0.50 
Market Cap ($ Bil)0.1 
First Trading Date01/02/2018 
Distance from 52W High-45.8% 
   50 Days200 Days
DMA Price$0.29$0.57
DMA Trenddowndown
Distance from DMA74.3%-11.2%
 3M1YR
Volatility198.2%128.6%
Downside Capture-0.730.37
Upside Capture34.737.86
Correlation (SPY)16.5%13.6%
CUE Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta1.541.401.901.831.201.26
Up Beta9.363.185.952.851.211.59
Down Beta1.710.891.823.501.591.91
Up Capture56%29%93%-50%2%2%
Bmk +ve Days7162765139424
Stock +ve Days12223359116324
Down Capture126%201%110%171%134%106%
Bmk -ve Days12233358110323
Stock -ve Days10203067133411

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-19.8%129.1%0.35-
Sector ETF (XLV)12.3%16.8%0.5215.4%
Equity (SPY)31.2%17.3%1.4721.2%
Gold (GLD)60.1%27.8%1.699.2%
Commodities (DBC)29.8%16.6%1.5814.1%
Real Estate (VNQ)21.3%15.2%1.0718.4%
Bitcoin (BTCUSD)-5.7%43.7%-0.0114.6%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-47.7%103.6%-0.18-
Sector ETF (XLV)6.3%14.6%0.2517.3%
Equity (SPY)11.1%17.0%0.5023.9%
Gold (GLD)22.1%17.8%1.026.6%
Commodities (DBC)11.8%18.8%0.529.4%
Real Estate (VNQ)3.7%18.8%0.1017.8%
Bitcoin (BTCUSD)4.0%56.5%0.2913.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CUE
CUE-27.1%93.1%-0.01-
Sector ETF (XLV)9.8%16.5%0.4821.7%
Equity (SPY)13.8%17.9%0.6626.8%
Gold (GLD)14.2%15.9%0.747.5%
Commodities (DBC)8.6%17.6%0.4112.9%
Real Estate (VNQ)5.1%20.7%0.2218.9%
Bitcoin (BTCUSD)67.4%66.9%1.0714.0%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date3312026
Short Interest: Shares Quantity2.7 Mil
Short Interest: % Change Since 315202617.2%
Average Daily Volume3.4 Mil
Days-to-Cover Short Interest1
Basic Shares Quantity108.1 Mil
Short % of Basic Shares2.5%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/16/2026-12.8%-14.5% 
11/12/2025-7.2%-13.1%-30.7%
8/12/20252.6%3.3%-3.1%
3/31/2025-17.7%-31.3%-17.1%
5/9/2024-9.1%-9.1%-24.8%
SUMMARY STATS   
# Positive110
# Negative444
Median Positive2.6%3.3% 
Median Negative-11.0%-13.8%-21.0%
Max Positive2.6%3.3% 
Max Negative-17.7%-31.3%-30.7%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/16/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/12/202510-Q
12/31/202403/31/202510-K
09/30/202411/14/202410-Q
06/30/202408/14/202410-Q
03/31/202405/09/202410-Q
12/31/202303/28/202410-K
09/30/202311/03/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202203/21/202310-K
09/30/202211/14/202210-Q
06/30/202208/04/202210-Q
03/31/202205/10/202210-Q

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 3/16/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Collaboration Revenue 5.00 Mil 0 AffirmedGuidance: 5.00 Mil for 2026

Prior: Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
Q4 2025 Collaboration Revenue 10.00 Mil   Higher New
2026 Collaboration Revenue 5.00 Mil   Higher New

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Sarraf, Pasha DirectBuy10220260.31323,85799,74799,747Form