Market Movers | Winners: MMED, TVGN, PRSO | Losers: CLDI, MDCX, CCHH

SPY: S&P 500 logo
SPY
S&P 500

On Friday, March 6, a broad-based downturn weighed on the S&P 500 falling 1.33%, the Dow 30 falling 0.95%, and the Nasdaq 100 falling 1.51%. Most stocks traded lower, with limited bright spots.
 

Trefis: RUA Stock Insights

List of Market Winners

The following table shows the list of 10 stocks that generated the highest returns on the last trading day:
 

# Ticker Company Name 1-D
Returns
YTD
Returns
1 MMED Minimed 87947.6% 87947.6%
2 TVGN Tevogen Bio 4613.1% -55.8%
3 PRSO Peraso 151.5% 134.5%
4 EDSA Edesa Biotech 80.6% 359.2%
5 ANTX AN2 Therapeutics 66.7% 150.0%
6 DAWN Day One Biopharmaceuticals 65.9% 127.5%
7 SEV Aptera Motors 39.0% -23.5%
8 COHN Cohen 36.2% -16.0%
9 QURE uniQure 34.0% -40.4%
10 AIFF Firefly Neuroscience 30.3% 111.4%

 
List of Market Losers

Relevant Articles
  1. Coherent Stock To $178?
  2. Bloom Energy Stock To $107?
  3. Sterling Infrastructure Stock To $285?
  4. Vistra Stock To $105?
  5. SPX Technologies Stock Sinks 23%, Rebound Coming?
  6. Stocks, Bonds, Gold, Crypto: Market Update 3/20/2026

On the other hand, the following table shows the list of 10 stocks that generated the lowest returns:
 

# Ticker Company Name 1-D
Returns
YTD
Returns
1 CLDI Calidi Biotherapeutics -53.1% -69.2%
2 MDCX Medicus Pharma -42.9% -74.7%
3 CCHH CCH -39.5% 21.8%
4 OWLT Owlet -38.2% -55.2%
5 SKYQ Sky Quarry -37.7% 54.4%
6 LNAI Lunai Bioworks -35.8% -73.7%
7 PROF Profound Medical -29.1% -32.5%
8 NVVE Nuvve -25.6% -63.4%
9 GPRO GoPro -24.0% -46.1%
10 FTCI FTC Solar -23.0% -61.9%

 
Why does this matter? Significant stock moves – up or down – deserve your attention. Sharp declines in fundamentally strong names can offer smart buying opportunities. And when momentum aligns with solid fundamentals, riding the trend can be highly rewarding.

You can’t predict what happens to individual stocks, but you can prepare. See how the Trefis High Quality Portfolio helps you.

Movers – Last One Week

Analysing over the last one week (5 trading days), a broad-based downturn weighed on the S&P 500 falling 2.02%, the Dow 30 falling 3.01%, and the Nasdaq 100 falling 1.27%. Most stocks traded lower, with limited bright spots.
 
List of 1-Week Market Winners

The following table shows the list of 10 stocks that generated the highest returns over the last week:
 

# Ticker Company Name 1-W
Returns
YTD
Returns
1 MMED Minimed 87947.6% 87947.6%
2 TVGN Tevogen Bio 2666.8% -55.8%
3 MOBX Mobix Labs 530.3% 289.1%
4 TPET Trio Petroleum 359.5% 143.1%
5 BATL Battalion Oil 305.1% 1878.8%
6 EDSA Edesa Biotech 196.4% 359.2%
7 AIFF Firefly Neuroscience 165.3% 111.4%
8 ANTX AN2 Therapeutics 159.1% 150.0%
9 PRSO Peraso 141.3% 134.5%
10 DAWN Day One Biopharmaceuticals 100.0% 127.5%

 
List of 1-Week Market Losers

Similarly, the following table shows the 10 stocks that were at the bottom in terms of returns:
 

# Ticker Company Name 1-W
Returns
YTD
Returns
1 MDCX Medicus Pharma -74.7% -74.7%
2 WORX SCWorx -63.5% -34.1%
3 CLDI Calidi Biotherapeutics -54.6% -69.2%
4 AARD Aardvark Therapeutics -53.2% -55.4%
5 AGIG Abundia Global Impact -51.2% 3.0%
6 ALUR Allurion Technologies -42.6% -45.4%
7 FTCI FTC Solar -42.5% -61.9%
8 CSTE Caesarstone -41.5% -56.9%
9 ALBT Avalon Globocare -38.5% -23.6%
10 ELAB PMGC -37.8% -87.5%

 
Movers – Last One Month

On a slightly wider timeline over the last one month, weakness was evident in the S&P 500 falling 2.07%, the Dow 30 falling 4.04%, and the Nasdaq 100 falling 1.00%. The pullback was broad, but select names remained resilient.
 
List of 1-Month Market Winners

The following table shows the 10 stocks that generated the maximum returns over the last one month:
 

# Ticker Company Name 1-M
Returns
YTD
Returns
1 MMED Minimed 87947.6% 87947.6%
2 ATPC Agape ATP 2507.1% -58.9%
3 RLYB Rallybio 1796.7% 98.8%
4 UGRO Urban-gro 1564.4% -65.3%
5 ASST Strive 1368.6% -41.1%
6 ADIL Adial Pharmaceuticals 1067.1% -66.7%
7 HCTI Healthcare Triangle 1059.8% -92.9%
8 PFSA Profusa 933.9% -88.7%
9 BATL Battalion Oil 747.0% 1878.8%
10 ANY Sphere 3D 716.0% -40.5%

 
List of 1-Month Market Losers

In the same period, these 10 stocks were at the bottom in terms of returns:
 

# Ticker Company Name 1-M
Returns
YTD
Returns
1 RPGL Republic Power -99.5% -99.4%
2 OBAI Our Bond -94.5% -94.5%
3 ROC Rank One Computing -92.0% -92.0%
4 AREB American Rebel -88.3% -98.9%
5 PLYX Polaryx Therapeutics -87.8% -92.2%
6 NUCL Eagle Nuclear Energy -86.0% -86.0%
7 LIMN Liminatus Pharma -83.8% -61.9%
8 ARTC Art Technology Acquisition -79.9% -79.9%
9 GOSS Gossamer Bio -79.6% -83.8%
10 RNA Atrium Therapeutics -79.6% -79.5%

 

Picking winners on a consistent basis is not an easy task – especially given the volatility associated with a single stock. Instead, the Trefis High Quality (HQ) Portfolio, with a collection of 30 stocks, has a track record of comfortably outperforming its benchmark that includes all 3 — the S&P 500, S&P mid-cap, and Russell 2000 indices. Why is that? As a group, HQ Portfolio stocks provided better returns with less risk versus the benchmark index; less of a roller-coaster ride, as evident in HQ Portfolio performance metrics.