Market Movers | Winners: ACXP, SAFX, SXTP | Losers: CODX, QNTM, KITT
On Wednesday, March 11, a calm session left the S&P 500 falling 0.08%, the Dow 30 falling 0.61%, and the Nasdaq 100 remaining flat nearly unchanged. Yet under the surface, there was more activity in specific names.

List of Market Winners
The following table shows the list of 10 stocks that generated the highest returns on the last trading day:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | ACXP | Acurx Pharmaceuticals | 107.9% | 142.2% |
| 2 | SAFX | XCF Global | 74.5% | 82.5% |
| 3 | SXTP | 60 Degrees Pharmaceuticals | 71.3% | 58.4% |
| 4 | ASNS | Actelis Networks | 47.6% | 12.2% |
| 5 | AMCI | AMC Robotics | 35.0% | 19.5% |
| 6 | BODI | Beachbody | 31.0% | 5.3% |
| 7 | OCGN | Ocugen | 29.9% | 70.4% |
| 8 | POLA | Polar Power | 26.8% | 16.2% |
| 9 | CVGI | Commercial Vehicle | 25.3% | 41.0% |
| 10 | SBNY | Signature Bank | 25.0% | -35.3% |
List of Market Losers
On the other hand, the following table shows the list of 10 stocks that generated the lowest returns:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | CODX | Co-Diagnostics | -26.4% | -35.9% |
| 2 | QNTM | Quantum BioPharma | -25.0% | -71.2% |
| 3 | KITT | Nauticus Robotics | -23.2% | 2.0% |
| 4 | CLIR | ClearSign Technologies | -21.6% | -19.5% |
| 5 | FCUV | Focus Universal | -20.7% | -45.3% |
| 6 | EZRA | Reliance Global | -18.6% | -23.6% |
| 7 | INKT | MiNK Therapeutics | -17.2% | 0.3% |
| 8 | PHGE | BiomX | -16.8% | 233.7% |
| 9 | KOS | Kosmos Energy | -16.6% | 121.5% |
| 10 | FWRD | Forward Air | -16.6% | -26.4% |
Why does this matter? Significant stock moves – up or down – deserve your attention. Sharp declines in fundamentally strong names can offer smart buying opportunities. And when momentum aligns with solid fundamentals, riding the trend can be highly rewarding.
Smart investing isn’t about stock picking or prediction, it’s about asset allocation. See how Trefis’ Boston-based wealth management partner does it. It has included the High Quality Portfolio as part of its asset allocation strategy.
Movers – Last One Week
Analysing over the last one week (5 trading days), a broad-based downturn weighed on the S&P 500 falling 1.36%, the Dow 30 falling 2.71%, and the Nasdaq 100 falling 0.51%. Most stocks traded lower, with limited bright spots.
List of 1-Week Market Winners
The following table shows the list of 10 stocks that generated the highest returns over the last week:
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | MMED | Minimed | 85852.4% | 85852.4% |
| 2 | CAST | FreeCast | 29529.6% | 29529.6% |
| 3 | TVGN | Tevogen Bio | 3917.2% | -54.8% |
| 4 | KIDZ | Classover | 2761.6% | -69.1% |
| 5 | DCOY | Decoy Therapeutics Inc. | 1096.3% | 1.0% |
| 6 | RVPH | Reviva Pharmaceuticals | 1050.2% | -49.6% |
| 7 | ADTX | Aditxt | 463.6% | -59.9% |
| 8 | ELAB | PMGC | 323.8% | -87.5% |
| 9 | ACXP | Acurx Pharmaceuticals | 296.7% | 142.2% |
| 10 | ANTX | AN2 Therapeutics | 279.9% | 346.5% |
List of 1-Week Market Losers
Similarly, the following table shows the 10 stocks that were at the bottom in terms of returns:
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | ALUR | Allurion Technologies | -65.7% | -78.8% |
| 2 | MDCX | Medicus Pharma | -64.8% | -68.3% |
| 3 | CLDI | Calidi Biotherapeutics | -56.5% | -70.4% |
| 4 | RBOT | Vicarious Surgical | -53.3% | -80.6% |
| 5 | LNAI | Lunai Bioworks | -50.1% | -78.4% |
| 6 | OWLT | Owlet | -49.3% | -62.8% |
| 7 | ARQ | Arq | -49.1% | -45.6% |
| 8 | CMCT | Creative Media & Community Trust | -45.9% | -64.7% |
| 9 | QNTM | Quantum BioPharma | -44.7% | -71.2% |
| 10 | CD | Chaince Digital | -38.0% | -0.6% |
Movers – Last One Month
On a slightly wider timeline over the last one month, selling pressure hit the S&P 500 falling 2.71%, the Dow 30 falling 5.42%, and the Nasdaq 100 falling 1.20%. Declines were common, though some stocks held steady.
List of 1-Month Market Winners
The following table shows the 10 stocks that generated the maximum returns over the last one month:
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | MMED | Minimed | 85852.4% | 85852.4% |
| 2 | CAST | FreeCast | 29529.6% | 29529.6% |
| 3 | ATPC | Agape ATP | 8427.6% | -21.7% |
| 4 | HCTI | Healthcare Triangle | 1940.0% | -91.9% |
| 5 | ANY | Sphere 3D | 847.1% | -45.9% |
| 6 | BATL | Battalion Oil | 582.5% | 1621.2% |
| 7 | EDSA | Edesa Biotech | 491.1% | 366.2% |
| 8 | ANTX | AN2 Therapeutics | 371.3% | 346.5% |
| 9 | RXT | Rackspace Technology | 361.0% | 97.8% |
| 10 | SGN | Signing Day Sports | 297.3% | -23.9% |
List of 1-Month Market Losers
In the same period, these 10 stocks were at the bottom in terms of returns:
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | RPGL | Republic Power | -99.4% | -99.5% |
| 2 | ROC | Rank One Computing | -92.4% | -92.4% |
| 3 | OBAI | Our Bond | -87.8% | -93.9% |
| 4 | AREB | American Rebel | -86.5% | -99.0% |
| 5 | NUCL | Eagle Nuclear Energy | -84.3% | -84.3% |
| 6 | LIMN | Liminatus Pharma | -82.4% | -58.2% |
| 7 | ARTC | Art Technology Acquisition | -79.8% | -79.8% |
| 8 | RNA | Atrium Therapeutics | -79.7% | -79.5% |
| 9 | RBOT | Vicarious Surgical | -79.5% | -80.6% |
| 10 | SHAZ | SharonAI | -78.6% | -78.6% |
Picking winners on a consistent basis is not an easy task – especially given the volatility associated with a single stock. Instead, the Trefis High Quality (HQ) Portfolio, with a collection of 30 stocks, has a track record of comfortably outperforming its benchmark that includes all 3 — the S&P 500, S&P mid-cap, and Russell 2000 indices. Why is that? As a group, HQ Portfolio stocks provided better returns with less risk versus the benchmark index; less of a roller-coaster ride, as evident in HQ Portfolio performance metrics.