Regeneron Pharmaceuticals (REGN)


Market Price (7/31/2026): $735.0 | Market Cap: $75.6 BilInvestor Relations Sector: Health Care | Industry: Biotechnology

Regeneron Pharmaceuticals (REGN)


Market Price (7/31/2026): $735.0
Market Cap: $75.6 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 6.2%

Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%

Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 30%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 23%, CFO LTM is 4.7 Bil, FCF LTM is 3.6 Bil

Stock buyback support
Stock Buyback 3Y Total is 11 Bil

Low stock price volatility
Vol 12M is 34%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.

Weak multi-year price returns
2Y Excs Rtn is -68%, 3Y Excs Rtn is -61%

Key risks
REGN key risks include [1] the erosion of flagship Eylea revenue from imminent biosimilar competition following patent expirations, Show more.

0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 6.2%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 30%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 23%, CFO LTM is 4.7 Bil, FCF LTM is 3.6 Bil
3 Stock buyback support
Stock Buyback 3Y Total is 11 Bil
4 Low stock price volatility
Vol 12M is 34%
5 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.
6 Weak multi-year price returns
2Y Excs Rtn is -68%, 3Y Excs Rtn is -61%
7 Key risks
REGN key risks include [1] the erosion of flagship Eylea revenue from imminent biosimilar competition following patent expirations, Show more.

REGN in ETFs

Weight = REGN's share of each fund

SPY0.10%
VOO0.10%
IVV0.10%
VTI0.09%
ITOT0.09%
QQQ0.31%
QQQM0.30%
IWB0.10%
+36 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 7/30/2026

Regeneron Pharmaceuticals (REGN) stock has lost about 5% since 3/31/2026 because of the following key factors:

1. Continued weakness and competitive pressures impacted the Eylea franchise.

In fiscal Q1 2026, reported on April 29, 2026, total U.S. net sales for the Eylea and Eylea HD franchise decreased 10% year-over-year to $941 million, marking the first time since fiscal Q2 2018 that the franchise's U.S. quarterly sales fell below $1 billion. This decline was primarily driven by competitive pressures, including from Roche's Vabysmo, and a significant 36% year-over-year drop in sales of the original Eylea formulation. Additionally, regulatory delays related to the FDA's decision on a second contract manufacturer for the Eylea HD pre-filled syringe created investor uncertainty.

2. The Phase 3 trial for fianlimab failed to meet its primary endpoint, leading to a significant stock drop.

In May 2026, Regeneron announced that its Phase 3 trial evaluating fianlimab in combination with cemiplimab as a first-line treatment for advanced melanoma did not achieve statistical significance for the primary endpoint of improved progression-free survival (PFS). This news resulted in a sharp decline of nearly 10% in Regeneron's stock price on May 18, 2026. The trial's failure and the subsequent investor reaction also led to a securities class action lawsuit against the company, alleging that it misrepresented the trial's prospects and risks.

Show more
Updated on 7/30/2026

Regeneron Pharmaceuticals (REGN) stock has lost about 5% since 3/31/2026 because of the following key factors:

1. Continued weakness and competitive pressures impacted the Eylea franchise.

In fiscal Q1 2026, reported on April 29, 2026, total U.S. net sales for the Eylea and Eylea HD franchise decreased 10% year-over-year to $941 million, marking the first time since fiscal Q2 2018 that the franchise's U.S. quarterly sales fell below $1 billion. This decline was primarily driven by competitive pressures, including from Roche's Vabysmo, and a significant 36% year-over-year drop in sales of the original Eylea formulation. Additionally, regulatory delays related to the FDA's decision on a second contract manufacturer for the Eylea HD pre-filled syringe created investor uncertainty.

2. The Phase 3 trial for fianlimab failed to meet its primary endpoint, leading to a significant stock drop.

In May 2026, Regeneron announced that its Phase 3 trial evaluating fianlimab in combination with cemiplimab as a first-line treatment for advanced melanoma did not achieve statistical significance for the primary endpoint of improved progression-free survival (PFS). This news resulted in a sharp decline of nearly 10% in Regeneron's stock price on May 18, 2026. The trial's failure and the subsequent investor reaction also led to a securities class action lawsuit against the company, alleging that it misrepresented the trial's prospects and risks.

3. An agreement with the U.S. government on drug pricing introduced long-term macroeconomic uncertainty.

Regeneron entered into an agreement with the U.S. government to lower drug prices, an initiative that, while advocated by the company, may have created investor apprehension regarding future pricing power and revenue stability for its key pharmaceutical products. This macroeconomic factor contributed to a cautious outlook on the company's financial trajectory.

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Stock Movement Drivers

Fundamental Drivers

The -4.3% change in REGN stock from 3/31/2026 to 7/30/2026 was primarily driven by a -11.3% change in the company's Net Income Margin (%).
(LTM values as of)33120267302026Change
Stock Price ($)771.49738.34-4.3%
Change Contribution By: 
Total Revenues ($ Mil)14,34315,5358.3%
Net Income Margin (%)31.4%27.9%-11.3%
P/E Multiple17.717.5-0.7%
Shares Outstanding (Mil)1031030.3%
Cumulative Contribution-4.3%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2026 to 7/30/2026
ReturnCorrelation
REGN-4.3% 
Market (SPY)14.0%15.7%
Sector (XLV)11.5%42.1%

Fundamental Drivers

The -4.1% change in REGN stock from 12/31/2025 to 7/30/2026 was primarily driven by a -13.3% change in the company's Net Income Margin (%).
(LTM values as of)123120257302026Change
Stock Price ($)769.79738.34-4.1%
Change Contribution By: 
Total Revenues ($ Mil)14,24815,5359.0%
Net Income Margin (%)32.1%27.9%-13.3%
P/E Multiple17.417.50.7%
Shares Outstanding (Mil)1041030.8%
Cumulative Contribution-4.1%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 7/30/2026
ReturnCorrelation
REGN-4.1% 
Market (SPY)9.1%24.6%
Sector (XLV)6.1%51.2%

Fundamental Drivers

The 41.4% change in REGN stock from 6/30/2025 to 7/30/2026 was primarily driven by a 41.6% change in the company's P/E Multiple.
(LTM values as of)63020257302026Change
Stock Price ($)522.14738.3441.4%
Change Contribution By: 
Total Revenues ($ Mil)14,08615,53510.3%
Net Income Margin (%)31.9%27.9%-12.8%
P/E Multiple12.417.541.6%
Shares Outstanding (Mil)1071033.8%
Cumulative Contribution41.4%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2025 to 7/30/2026
ReturnCorrelation
REGN41.4% 
Market (SPY)21.1%17.8%
Sector (XLV)22.9%48.9%

Fundamental Drivers

The 3.6% change in REGN stock from 6/30/2023 to 7/30/2026 was primarily driven by a 25.6% change in the company's Total Revenues ($ Mil).
(LTM values as of)63020237302026Change
Stock Price ($)712.65738.343.6%
Change Contribution By: 
Total Revenues ($ Mil)12,37015,53525.6%
Net Income Margin (%)33.8%27.9%-17.6%
P/E Multiple18.217.5-3.9%
Shares Outstanding (Mil)1071034.2%
Cumulative Contribution3.6%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2023 to 7/30/2026
ReturnCorrelation
REGN3.6% 
Market (SPY)73.2%29.7%
Sector (XLV)29.0%49.4%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
REGN Return31%14%22%-19%9%-10%45%
Peers Return21%20%-11%4%15%18%83%
S&P 500 Return27%-19%24%23%16%7%95%

Monthly Win Rates [3]
REGN Win Rate67%50%58%50%50%43% 
Peers Win Rate53%62%38%50%53%63% 
S&P 500 Win Rate75%42%67%75%67%43% 

Max Drawdowns [4]
REGN Max Drawdown-20%-26%-17%-42%-35%-26% 
Peers Max Drawdown-19%-18%-27%-23%-23%-14% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: AMGN, MRK, BMY, ABBV, PFE. See REGN Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 7/30/2026 (YTD)

How Low Can It Go

EventREGNS&P 500
2025 US Tariff Shock
  % Loss-29.4%-18.8%
  % Gain to Breakeven41.5%23.1%
  Time to Breakeven161 days79 days
2022 Inflation Shock & Fed Tightening
  % Loss-12.6%-24.5%
  % Gain to Breakeven14.4%32.4%
  Time to Breakeven55 days427 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-16.7%-19.2%
  % Gain to Breakeven20.0%23.8%
  Time to Breakeven76 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-19.8%-3.7%
  % Gain to Breakeven24.7%3.9%
  Time to Breakeven7 days6 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-36.8%-12.2%
  % Gain to Breakeven58.2%13.9%
  Time to Breakeven1517 days62 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-21.8%-17.9%
  % Gain to Breakeven27.8%21.8%
  Time to Breakeven7 days123 days

Compare to AMGN, MRK, BMY, ABBV, PFE

In The Past

Regeneron Pharmaceuticals's stock fell -29.4% during the 2025 US Tariff Shock. Such a loss loss requires a 41.5% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventREGNS&P 500
2025 US Tariff Shock
  % Loss-29.4%-18.8%
  % Gain to Breakeven41.5%23.1%
  Time to Breakeven161 days79 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-36.8%-12.2%
  % Gain to Breakeven58.2%13.9%
  Time to Breakeven1517 days62 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-21.8%-17.9%
  % Gain to Breakeven27.8%21.8%
  Time to Breakeven7 days123 days
2008-2009 Global Financial Crisis
  % Loss-51.1%-53.4%
  % Gain to Breakeven104.6%114.4%
  Time to Breakeven294 days1085 days
Summer 2007 Credit Crunch
  % Loss-24.7%-8.6%
  % Gain to Breakeven32.9%9.5%
  Time to Breakeven6 days47 days

Compare to AMGN, MRK, BMY, ABBV, PFE

In The Past

Regeneron Pharmaceuticals's stock fell -29.4% during the 2025 US Tariff Shock. Such a loss loss requires a 41.5% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Regeneron Pharmaceuticals (REGN)

Regeneron Pharmaceuticals, Inc. is a leading biopharmaceutical company engaged in the discovery, invention, development, manufacture, and commercialization of a broad range of innovative medicines globally. The company focuses on leveraging its scientific platforms to create novel treatments for serious diseases, spanning from chronic conditions and autoimmune disorders to various cancers and infectious diseases.

The company's main product portfolio features several key therapies. EYLEA is a cornerstone product, widely used to treat serious eye conditions such as wet age-related macular degeneration and diabetic macular edema. Dupixent represents another significant offering, addressing allergic and inflammatory diseases like atopic dermatitis and asthma. Regeneron also markets Libtayo for certain types of skin cancer, Praluent for cardiovascular conditions, and Kevzara for rheumatoid arthritis, alongside treatments for rare diseases and infectious agents like the Zaire ebolavirus.

Regeneron's primary customers are patients worldwide suffering from a diverse array of medical conditions. Its medicines serve critical markets in ophthalmology, immunology, oncology, cardiovascular and metabolic health, and infectious and rare diseases. Through ongoing research and strategic collaborations, Regeneron aims to continuously expand its therapeutic reach and bring much-needed treatments to patients facing debilitating and life-threatening illnesses.

AI Analysis | Feedback

Think of them as a major pharmaceutical company like **Merck** or **Novartis**, but with a particularly strong track record for discovering and developing innovative blockbuster drugs in areas like eye disease and immunology.

They are like a leading biotech innovator such as **Amgen**, but with a more diverse portfolio of widely-used treatments, including drugs for conditions like macular degeneration, asthma, and certain cancers.

AI Analysis | Feedback

  • EYLEA injection: A treatment for various eye conditions including wet age-related macular degeneration, diabetic macular edema, and diabetic retinopathy.
  • Dupixent injection: Used to treat atopic dermatitis and asthma in both adults and pediatric patients.
  • Libtayo injection: Prescribed for metastatic or locally advanced cutaneous squamous cell carcinoma.
  • Praluent injection: An adult treatment for heterozygous familial hypercholesterolemia or clinical atherosclerotic cardiovascular disease.
  • REGEN-COV: Developed for the treatment of COVID-19.
  • Kevzara solution: A treatment for rheumatoid arthritis in adults.
  • Inmazeb injection: Used for infections caused by the Zaire ebolavirus.
  • ARCALYST injection: Administered for cryopyrin-associated periodic syndromes.
  • ZALTRAP injection: An intravenous infusion to treat metastatic colorectal cancer.

AI Analysis | Feedback

Regeneron Pharmaceuticals (REGN) sells its products primarily to other companies and governmental entities within the healthcare supply chain, rather than directly to individual consumers.

The major customers for Regeneron's pharmaceutical products are typically large pharmaceutical wholesalers and distributors who then supply pharmacies, hospitals, and other healthcare providers. Additionally, government agencies can be significant direct purchasers for certain products, as indicated by the company's agreement with the U.S. Department of Health and Human Services for REGEN-COV.

The major customer companies (pharmaceutical wholesalers) include:

  • McKesson Corporation (MCK)
  • AmerisourceBergen Corporation (ABC)
  • Cardinal Health, Inc. (CAH)

In addition to these wholesalers, the U.S. Department of Health and Human Services is identified as a direct customer for specific products like REGEN-COV.

AI Analysis | Feedback

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Leonard S. Schleifer, MD, PhD
Co-Chairman of the Board, President and Chief Executive Officer

Dr. Leonard S. Schleifer co-founded Regeneron Pharmaceuticals in 1988 with the vision of building a science-driven company focused on helping patients. He has served as President and Chief Executive Officer since the company's inception and became Co-Chairman of the Board in June 2023. Prior to founding Regeneron, Dr. Schleifer earned his M.D. and Ph.D. in pharmacology from the University of Virginia, and was a practicing neurologist and professor at Cornell Medical School. He was motivated to start the company due to the lack of effective treatments for serious neurodegenerative diseases.

Christopher Fenimore
Executive Vice President, Finance and Chief Financial Officer

Christopher Fenimore was appointed Executive Vice President, Finance and Chief Financial Officer of Regeneron in January 2025, having initially become CFO in February 2024. He joined Regeneron in 2003 and has held various finance leadership roles within the company, including Senior Vice President, Controller; Vice President, Controller; and Vice President, Financial Planning and Analysis. Before joining Regeneron, Mr. Fenimore served as Vice President of Finance for a biotechnology start-up and held roles in healthcare industry-focused venture capital and investment banking. He began his career as an auditor at KPMG and is a Certified Public Accountant in New York.

George D. Yancopoulos, MD, PhD
Co-Chairman of the Board, President and Chief Scientific Officer

Dr. George D. Yancopoulos is the co-founder, Co-Chairman of the Board, President, and Chief Scientific Officer of Regeneron, which he joined in 1989. He is recognized as a highly successful scientist and drug discoverer, and is a principal inventor and developer of Regeneron's foundational technologies and numerous FDA-approved treatments. Dr. Yancopoulos graduated as valedictorian of the Bronx High School of Science and Columbia College, and earned his M.D. and Ph.D. in Biochemistry and Molecular Biophysics from Columbia University. He left an academic career to co-found Regeneron alongside Dr. Leonard Schleifer.

Joseph J. LaRosa
Executive Vice President, General Counsel and Secretary

Joseph J. LaRosa joined Regeneron in 2011 and currently serves as Executive Vice President, General Counsel and Secretary. Prior to Regeneron, Mr. LaRosa was Senior Vice President, General Counsel and Secretary at Nycomed U.S., Inc. His previous experience also includes serving as Vice President, Global Compliance and Legal Affairs at Avon Products, Inc., and holding several senior legal positions at Schering-Plough Corporation, where he was a corporate officer and Vice President, Legal Affairs. Mr. LaRosa received his J.D. degree from New York University School of Law.

Daniel Van Plew
Executive Vice President & General Manager, Industrial Operations and Product Supply

Daniel Van Plew joined Regeneron in 2007 and has served as Executive Vice President and General Manager, Industrial Operations and Product Supply since January 2016. Before joining Regeneron, he was Executive Vice President, R&D and Technical Operations for Crucell Holland B.V., a global biopharmaceutical company, from 2006 to 2007. He also held positions of increasing responsibility at Chiron Biopharmaceuticals, including Senior Director, Vacaville Operations, and worked in various managerial roles in the health and life sciences practice at Accenture. Mr. Van Plew holds an M.S. in Chemistry from Pennsylvania State University and an M.B.A. from Michigan State University.

AI Analysis | Feedback

Regeneron Pharmaceuticals (REGN) faces several key risks to its business, primarily centered around its blockbuster products and the highly competitive pharmaceutical landscape.

  1. Erosion of Eylea Revenue due to Patent Expiration and Biosimilar Competition: Regeneron's flagship eye drug, Eylea, is experiencing significant revenue erosion due to the expiration of key patents and the subsequent entry of biosimilar competitors, such as Amgen's Pavblu and Samsung Bioepis' Opuviz. This patent cliff, combined with competition from innovative rival drugs like Roche's Vabysmo, has already led to a decline in Eylea's U.S. net sales. While Regeneron has launched Eylea HD to mitigate these effects, its success is crucial in offsetting the decline, and the company has already faced regulatory setbacks, including an FDA rejection for a prefilled syringe version of Eylea HD due to a manufacturing issue.
  2. Heavy Reliance on Key Blockbuster Products and the Imperative for Successful Pipeline Development: Regeneron is significantly dependent on the commercial success of a limited number of key products, primarily Eylea and Dupixent, for a substantial portion of its revenue. While Dupixent's patent exclusivity is anticipated to last until 2030/2031, the challenges faced by Eylea underscore the vulnerability of relying heavily on a few top-selling drugs. Therefore, the successful development and commercialization of new product candidates from its clinical pipeline are critically important to offset revenue declines from mature products and drive future growth. Failures in clinical trials, such as the recent Phase III setback for itepekimab, a Dupixent follow-up drug, pose a significant risk to the company's growth prospects.
  3. Intensified Market Competition and Regulatory/Manufacturing Hurdles: The biopharmaceutical industry is characterized by intense competition from both established pharmaceutical companies and emerging biotech firms across all therapeutic areas. Products like Dupixent, while currently successful, are facing increasing competitive pressures from new rivals entering the market or in advanced stages of development. Furthermore, Regeneron operates in a heavily regulated environment, and challenges in navigating complex regulatory approval processes, including unexpected actions or delays from authorities like the FDA, can significantly impact the availability and commercial potential of its products. Manufacturing and supply chain disruptions or quality control issues also represent ongoing operational risks that can delay product launches and affect financial results.

AI Analysis | Feedback

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Regeneron Pharmaceuticals (REGN) operates in various therapeutic areas with several key products. The addressable markets for its main products are significant across different regions, primarily globally.

EYLEA (Aflibercept)

EYLEA targets multiple ophthalmic conditions, each representing a substantial market:

  • Wet Age-Related Macular Degeneration (wAMD): The global market size for wet age-related macular degeneration was estimated at USD 10.1 billion in 2024 and is projected to reach USD 20 billion by 2034. In the 7 major markets (US, EU4, UK, and Japan), the wet AMD market reached USD 9,528.8 million in 2024 and is expected to grow to USD 18,317.5 million by 2035.
  • Diabetic Macular Edema (DME): The global diabetic macular edema market size was valued at USD 3.33 billion in 2024 and is projected to reach USD 4.34 billion by 2032. Another estimate indicates the global DME market is expected to grow from USD 5.50 billion in 2024 to USD 8.64 billion by 2035.
  • Diabetic Retinopathy (DR): The global diabetic retinopathy market size was estimated at USD 9.48 billion in 2024 and is expected to grow to USD 13.77 billion by 2030. Other projections place the global diabetic retinopathy market at USD 10.23 billion in 2025, reaching USD 18.93 billion by 2035.
  • Macular Edema following Retinal Vein Occlusion (RVO): The global retinal vein occlusion market size was calculated at USD 2.82 billion in 2024 and is predicted to reach approximately USD 5.45 billion by 2034.

Dupixent (Dupilumab)

Dupixent is a significant product for allergic and inflammatory conditions:

  • Overall Dupixent Market: The global Dupixent market size was estimated at USD 14.15 billion in 2024 and is projected to reach USD 27.58 billion by 2033.
  • Atopic Dermatitis: The global atopic dermatitis drugs market size was estimated at USD 17.64 billion in 2024 and is projected to reach USD 29.88 billion by 2030. Other analyses suggest the global atopic dermatitis drug market size, calculated at USD 15.92 billion in 2025, is predicted to increase to approximately USD 33.42 billion by 2035.

Libtayo (Cemiplimab)

Libtayo addresses certain cancers:

  • Cutaneous Squamous Cell Carcinoma (CSCC) Treatment: The global cutaneous squamous cell carcinoma treatment market size is estimated at USD 13.69 billion in 2024 and is projected to reach approximately USD 27.54 billion by 2034.

Praluent (Alirocumab)

Praluent targets cholesterol management:

  • Heterozygous Familial Hypercholesterolemia (HeFH) Management: The global heterozygous familial hypercholesterolemia management market size is expected to grow from USD 12.04 billion in 2025 to USD 20.12 billion by 2030.

Kevzara (Sarilumab)

Kevzara is used for autoimmune diseases:

  • Rheumatoid Arthritis (RA) Therapeutics: The global rheumatoid arthritis therapeutics market size was estimated at USD 25.76 billion in 2024 and is projected to reach USD 41.42 billion by 2033. Another report valued the global market for rheumatoid arthritis therapies at USD 28.5 billion in 2024, estimated to increase to USD 41.1 billion by 2030.

AI Analysis | Feedback

Here are 3-5 expected drivers of future revenue growth for Regeneron Pharmaceuticals (REGN) over the next 2-3 years: * **Continued Expansion of Dupixent (dupilumab)**: Dupixent remains a significant growth engine for Regeneron, driven by its broad adoption across existing approved indications such as atopic dermatitis and asthma. Future growth is expected from further label expansions into new disease areas like chronic spontaneous urticaria (CSU), pediatric asthma, eosinophilic esophagitis, chronic obstructive pulmonary disease (COPD), and allergic fungal rhinosinusitis. The drug's patent exclusivity is projected to last until 2030/2031, providing a solid runway for continued revenue generation. Regeneron's share of profits from the commercialization of Dupixent is also increasing. * **Increased Adoption and New Indications for EYLEA HD (aflibercept high-dose)**: While the original EYLEA faces competitive pressure from biosimilars, EYLEA HD is positioned as a key revenue driver. Recent FDA approvals for macular edema following retinal vein occlusion (RVO) and a flexible monthly dosing option across all approved indications are expected to boost its market share. The anticipated approval of a pre-filled syringe formulation for EYLEA HD in the second quarter of 2026 is also expected to enhance convenience and contribute to its growth. * **Advancement and Commercialization of Late-Stage Pipeline Products**: Regeneron boasts a robust and diversified late-stage pipeline with approximately 45 product candidates across various therapeutic areas, including hematology, immunology, oncology, rare genetic disorders, and weight management. Several upcoming regulatory decisions and potential new product launches in 2026 are anticipated to fuel revenue growth. Key examples include the FDA's target action date in August 2026 for garetosmab for fibrodysplasia ossificans progressiva (FOP), expected data for fianlimab/Libtayo LAG-3 in melanoma in the first half of 2026, and an NDA submission for cemdisiran in generalized myasthenia gravis in the first quarter of 2026. Additionally, promising results from the GLP-1 diabetes and weight loss drug olatorepatide suggest significant future revenue potential upon approval. * **Growth of Libtayo (cemiplimab) in Oncology**: Libtayo continues to be a growth contributor for Regeneron, particularly within the oncology segment. It has achieved increased sales and secured new approvals, such as for adjuvant cutaneous squamous cell carcinoma (CSCC), and is recognized as a leading immunotherapy for non-melanoma skin cancers. While its most significant revenue impact is projected beyond 2026, its ongoing performance and label expansions contribute to the company's near-term growth.

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Share Repurchases

  • Regeneron Pharmaceuticals authorized a $3 billion share repurchase program in November 2021, with an additional $1.8 million remaining from a previous $1.5 billion program.
  • The company repurchased $2.235 billion in 2023, $2.603 billion in 2024, and $3.439 billion in 2025.
  • As of February 2026, approximately $1.486 billion remained available for future share repurchases under authorized programs.

Outbound Investments

  • Regeneron made a Series C investment in Truveta on January 13, 2025.
  • The company invested in Enlaza (Series A, April 30, 2024) and Vyriad (Series B, May 17, 2022).
  • In Q2 2025, Regeneron in-licensed rights to a late-stage dual GLP-1/GIP receptor agonist, and in Q3 2025, made an $80 million upfront payment for a license agreement with Hansoh Pharmaceuticals Group Company Limited.

Capital Expenditures

  • Capital expenditures were $718.6 million in 2023, $755.9 million in 2024, and $898.4 million in 2025.
  • Regeneron plans to invest approximately $1.1 billion to $1.3 billion in 2026 for facility expansions.
  • The company has committed to over $7 billion in U.S. investments, including expansions in Tarrytown and Rensselaer, NY, and a new agreement to double U.S. large-scale manufacturing capacity, and an additional $2 billion for a new bulk manufacturing facility in Saratoga Springs, NY. These investments aim to significantly expand manufacturing capacity and support ongoing manufacturing operations.

Better Bets vs. Regeneron Pharmaceuticals (REGN)

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Peer Comparisons

Peers to compare with:

Financials

REGNAMGNMRKBMYABBVPFEMedian
NameRegenero.Amgen Merck Bristol-.AbbVie Pfizer  
Mkt Price738.34387.64129.7964.86257.4124.91193.60
Mkt Cap75.9209.3320.8132.4455.6141.8175.5
Rev LTM15,53537,22065,76849,18762,81963,31456,003
Op Inc LTM4,17410,56812,97013,84220,84415,50813,406
FCF LTM3,5758,59714,11511,44019,9809,48310,462
FCF 3Y Avg3,4398,87014,06512,98819,0858,60310,929
CFO LTM4,68110,75617,89012,78221,22411,98412,383
CFO 3Y Avg4,49810,34817,84214,28220,10411,51712,900

Growth & Margins

REGNAMGNMRKBMYABBVPFEMedian
NameRegenero.Amgen Merck Bristol-.AbbVie Pfizer  
Rev Chg LTM9.3%9.1%2.9%3.1%9.5%1.4%6.1%
Rev Chg 3Y Avg7.0%12.5%4.4%2.9%3.6%-9.2%4.0%
Rev Chg Q16.7%5.8%4.9%5.7%12.4%5.4%5.7%
QoQ Delta Rev Chg LTM4.1%1.3%1.2%1.5%2.7%1.2%1.4%
Op Inc Chg LTM6.1%41.9%-36.4%39.1%61.4%3.1%22.6%
Op Inc Chg 3Y Avg-1.7%8.8%69.7%22.3%12.1%203.9%17.2%
Op Mgn LTM26.9%28.4%19.7%28.1%33.2%24.5%27.5%
Op Mgn 3Y Avg28.2%24.6%19.9%21.4%26.9%17.3%23.0%
QoQ Delta Op Mgn LTM1.1%3.7%-14.3%0.1%0.3%-0.7%0.2%
CFO/Rev LTM30.1%28.9%27.2%26.0%33.8%18.9%28.1%
CFO/Rev 3Y Avg31.2%30.7%28.0%29.9%34.7%18.9%30.3%
FCF/Rev LTM23.0%23.1%21.5%23.3%31.8%15.0%23.1%
FCF/Rev 3Y Avg23.9%26.4%22.0%27.2%33.0%14.0%25.1%

Valuation

REGNAMGNMRKBMYABBVPFEMedian
NameRegenero.Amgen Merck Bristol-.AbbVie Pfizer  
Mkt Cap75.9209.3320.8132.4455.6141.8175.5
P/S4.95.64.92.77.32.24.9
P/Op Inc18.219.824.79.621.99.119.0
P/EBIT14.517.824.49.751.313.416.2
P/E17.526.835.914.3125.318.922.9
P/CFO16.219.517.910.421.511.817.1
Total Yield6.2%6.2%5.4%10.9%3.4%12.2%6.2%
Dividend Yield0.5%2.5%2.6%3.8%2.6%6.9%2.6%
FCF Yield 3Y Avg4.9%5.3%5.5%13.5%5.5%6.1%5.5%
D/E0.00.30.20.30.20.40.2
Net D/E-0.10.20.10.30.10.40.2

Returns

REGNAMGNMRKBMYABBVPFEMedian
NameRegenero.Amgen Merck Bristol-.AbbVie Pfizer  
1M Rtn18.4%7.0%1.0%13.8%3.0%5.3%6.2%
3M Rtn4.6%12.8%19.7%8.3%22.7%-3.5%10.5%
6M Rtn-1.2%14.7%21.6%22.1%18.6%-1.3%16.6%
12M Rtn33.9%32.5%64.1%47.8%40.2%12.0%37.0%
3Y Rtn0.3%81.5%33.5%20.1%90.9%-16.2%26.8%
1M Excs Rtn19.2%7.9%1.8%14.7%3.8%6.1%7.0%
3M Excs Rtn3.5%11.3%13.6%9.7%22.9%-6.1%10.5%
6M Excs Rtn-8.0%8.3%16.6%14.7%13.0%-7.0%10.6%
12M Excs Rtn16.3%14.8%45.6%28.3%22.0%-7.0%19.2%
3Y Excs Rtn-60.8%17.8%-30.5%-45.7%38.7%-80.4%-38.1%

Comparison Analyses

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Collaboration revenue7,3316,0585,5034,9143,673
EYLEA ®2,7484,7675,7206,2655,792
EYLEA HD ®1,6371,20116600
Libtayo ®945787539374306
Other revenue703515536365281
Libtayo508430324730
Praluent ®262242182130170
Evkeeza ®162126774918
Inmazeb ®37777030
Other products1000  
ARCALYST ®    2
REGEN-COV ®    5,828
Total14,34314,20213,11712,17316,072


Operating Income by Segment
$ Mil2003200220012000
Contract Manufacturing3531
Research and Development-104-127-90 
R & D   -33
Reconciling   8
Total-100-122-87-23


Assets by Segment
$ Mil20062005200420032002
Research and Development57961119276
Contract Manufacturing0471312
Total5710011810588


Price Behavior

Price Behavior
Market Price$738.34 
Market Cap ($ Bil)76.8 
First Trading Date04/02/1991 
Distance from 52W High-8.9% 
   50 Days200 Days
DMA Price$641.02$707.39
DMA Trendupdown
Distance from DMA15.2%4.4%
 3M1YR
Volatility35.5%33.7%
Downside Capture16.3042.51
Upside Capture34.2268.23
Correlation (SPY)7.2%15.2%
REGN Betas & Captures as of 6/30/2026

 1M2M3M6M1Y3Y
Beta-0.040.210.520.560.450.60
Up Beta1.071.531.491.360.790.61
Down Beta0.44-0.60-0.98-0.23-0.240.41
Up Capture-42%-28%-7%20%55%29%
Bmk +ve Days11244067140429
Stock +ve Days13192756123379
Down Capture-58%61%110%90%65%94%
Bmk -ve Days10172358112321
Stock -ve Days8223669128370

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with REGN
REGN33.2%33.7%0.89-
Sector ETF (XLV)23.3%15.9%1.1348.3%
Equity (SPY)17.8%12.9%1.0117.0%
Gold (GLD)23.3%28.1%0.739.9%
Commodities (DBC)29.4%19.7%1.19-22.7%
Real Estate (VNQ)12.7%13.9%0.6220.6%
Bitcoin (BTCUSD)-46.2%42.9%-1.328.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with REGN
REGN4.9%31.0%0.19-
Sector ETF (XLV)6.3%15.0%0.2450.8%
Equity (SPY)12.7%17.1%0.5732.5%
Gold (GLD)17.4%18.4%0.764.3%
Commodities (DBC)9.0%19.5%0.35-2.9%
Real Estate (VNQ)2.8%18.9%0.0528.3%
Bitcoin (BTCUSD)14.5%53.3%0.459.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with REGN
REGN6.8%32.2%0.28-
Sector ETF (XLV)10.0%16.6%0.4951.9%
Equity (SPY)14.9%17.9%0.7137.2%
Gold (GLD)11.6%16.1%0.593.8%
Commodities (DBC)7.2%18.0%0.325.0%
Real Estate (VNQ)5.0%20.7%0.2025.7%
Bitcoin (BTCUSD)57.8%66.2%0.988.8%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date7152026
Short Interest: Shares Quantity3.5 Mil
Short Interest: % Change Since 63020260.2%
Average Daily Volume0.7 Mil
Days-to-Cover Short Interest4.7 days
Basic Shares Quantity102.8 Mil
Short % of Basic Shares3.4%

Earnings Returns History

Updated 7/30/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
4/29/2026-6.2%-4.0%-14.9%
1/30/2026-1.1%2.3%5.6%
10/28/202511.8%9.7%34.7%
8/1/20252.5%2.6%6.6%
4/29/2025-6.9%-1.2%-3.0%
2/4/20254.5%3.5%3.2%
10/31/2024-9.2%-11.5%-18.7%
8/1/20241.3%-1.1%9.2%
...
SUMMARY STATS   
# Positive151114
# Negative91310
Median Positive3.5%4.7%5.9%
Median Negative-3.7%-3.3%-6.5%
Max Positive11.8%9.7%34.7%
Max Negative-9.2%-11.5%-18.7%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
4/29/2026-6.2%-4.0%-14.9%
1/30/2026-1.1%2.3%5.6%
10/28/202511.8%9.7%34.7%
8/1/20252.5%2.6%6.6%
4/29/2025-6.9%-1.2%-3.0%
2/4/20254.5%3.5%3.2%
10/31/2024-9.2%-11.5%-18.7%
8/1/20241.3%-1.1%9.2%
5/2/20243.8%5.8%8.5%
2/2/2024-1.3%-1.2%1.4%
11/2/20233.5%4.0%3.0%
8/3/20235.4%7.3%12.9%
5/4/2023-6.1%-6.7%-7.9%
2/3/20234.3%-0.9%3.9%
11/3/2022-0.2%0.3%3.5%
8/3/20225.9%8.2%1.1%
5/4/20220.1%-6.9%-4.5%
2/4/20220.4%-0.4%-0.3%
11/4/2021-0.7%-4.6%-2.6%
8/5/20213.7%4.7%16.3%
5/6/20213.4%5.1%6.1%
2/5/20210.0%-1.7%-7.1%
11/5/20200.3%-3.3%-16.1%
8/5/2020-3.7%-7.6%-5.9%
SUMMARY STATS   
# Positive151114
# Negative91310
Median Positive3.5%4.7%5.9%
Median Negative-3.7%-3.3%-6.5%
Max Positive11.8%9.7%34.7%
Max Negative-9.2%-11.5%-18.7%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202607/30/202610-Q
03/31/202604/29/202610-Q
12/31/202502/04/202610-K
09/30/202510/28/202510-Q
06/30/202508/01/202510-Q
03/31/202504/29/202510-Q
12/31/202402/05/202510-K
09/30/202410/31/202410-Q
06/30/202408/01/202410-Q
03/31/202405/02/202410-Q
12/31/202302/05/202410-K
09/30/202311/02/202310-Q
06/30/202308/03/202310-Q
03/31/202305/04/202310-Q
12/31/202202/06/202310-K
09/30/202211/03/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202607/30/202610-Q
03/31/202604/29/202610-Q
12/31/202502/04/202610-K
09/30/202510/28/202510-Q
06/30/202508/01/202510-Q
03/31/202504/29/202510-Q
12/31/202402/05/202510-K
09/30/202410/31/202410-Q
06/30/202408/01/202410-Q
03/31/202405/02/202410-Q
12/31/202302/05/202410-K
09/30/202311/02/202310-Q
06/30/202308/03/202310-Q
03/31/202305/04/202310-Q
12/31/202202/06/202310-K
09/30/202211/03/202210-Q
06/30/202208/03/202210-Q
03/31/202205/04/202210-Q
12/31/202102/07/202210-K
09/30/202111/04/202110-Q
06/30/202108/05/202110-Q
03/31/202105/06/202110-Q
12/31/202002/08/202110-K
09/30/202011/05/202010-Q
06/30/202008/05/202010-Q
03/31/202005/05/202010-Q
12/31/201902/07/202010-K
09/30/201911/05/201910-Q

Recent Forward Guidance

Updated 7/8/2026

Latest: Q1 2026 Earnings Reported 4/29/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 GAAP R&D6.45 Bil6.57 Bil6.68 Bil0 AffirmedGuidance: 6.57 Bil for 2026
2026 Non-GAAP R&D5.90 Bil6.00 Bil6.10 Bil0 AffirmedGuidance: 6.00 Bil for 2026
2026 GAAP SG&A2.86 Bil2.95 Bil3.04 Bil0 AffirmedGuidance: 2.95 Bil for 2026
2026 Non-GAAP SG&A2.50 Bil2.58 Bil2.65 Bil0 AffirmedGuidance: 2.58 Bil for 2026
2026 GAAP gross margin on net product sales77.0%77.5%78.0% -2.0%LoweredGuidance: 79.5% for 2026
2026 Non-GAAP gross margin on net product sales83.0%83.5%84.0% 0AffirmedGuidance: 83.5% for 2026
2026 GAAP COCM955.00 Mil995.00 Mil1.03 Bil1.5% RaisedGuidance: 980.00 Mil for 2026
2026 Non-GAAP COCM940.00 Mil980.00 Mil1.02 Bil0 AffirmedGuidance: 980.00 Mil for 2026
2026 Capital expenditures1.10 Bil1.15 Bil1.20 Bil-4.2% LoweredGuidance: 1.20 Bil for 2026
2026 GAAP effective tax rate12.0%13.0%14.0% 0AffirmedGuidance: 13.0% for 2026
2026 Non-GAAP effective tax rate13.0%14.0%15.0% 0AffirmedGuidance: 14.0% for 2026

Prior: Q4 2025 Earnings Reported 1/30/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 GAAP R&D6.45 Bil6.57 Bil6.68 Bil14.9% Higher NewGuidance: 5.71 Bil for 2025
2026 Non-GAAP R&D5.90 Bil6.00 Bil6.10 Bil15.9% Higher NewGuidance: 5.17 Bil for 2025
2026 GAAP SG&A2.86 Bil2.95 Bil3.04 Bil5.0% Higher NewGuidance: 2.81 Bil for 2025
2026 Non-GAAP SG&A2.50 Bil2.58 Bil2.65 Bil6.2% Higher NewGuidance: 2.42 Bil for 2025
2026 GAAP gross margin on net product sales79.0%79.5%80.0%   
2026 Non-GAAP gross margin on net product sales83.0%83.5%84.0%   
2026 COCM940.00 Mil980.00 Mil1.02 Bil0.5% Higher NewGuidance: 975.00 Mil for 2025
2026 Capital expenditures1.10 Bil1.20 Bil1.30 Bil37.9% Higher NewGuidance: 870.00 Mil for 2025
2026 GAAP effective tax rate12.0%13.0%14.0%   
2026 Non-GAAP effective tax rate13.0%14.0%15.0%   

Q3 2025 Earnings Reported 10/28/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2025 GAAP R&D5.68 Bil5.71 Bil5.75 Bil-0.2% LoweredGuidance: 5.72 Bil for 2025
2025 Non-GAAP R&D5.15 Bil5.17 Bil5.20 Bil0.5% RaisedGuidance: 5.15 Bil for 2025
2025 GAAP SG&A2.77 Bil2.81 Bil2.85 Bil-2.3% LoweredGuidance: 2.88 Bil for 2025
2025 Non-GAAP SG&A2.40 Bil2.42 Bil2.45 Bil-3.0% LoweredGuidance: 2.50 Bil for 2025
2025 COCM950.00 Mil975.00 Mil1.00 Bil-4.9% LoweredGuidance: 1.02 Bil for 2025
2025 Capital Expenditures850.00 Mil870.00 Mil890.00 Mil-4.9% LoweredGuidance: 915.00 Mil for 2025

Insider Activity

Updated 7/7/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Ryan, Arthur F DirectSell7072026650.15200130,03011,249,545Form
2Ryan, Arthur F DirectSell5042026705.2410070,52412,343,781Form
3Ryan, Arthur FDirectSell4032026777.2710077,72713,682,333Form
4Ryan, Arthur F DirectSell3032026785.5010078,55013,905,627Form
5Zoghbi, Huda Y DirectSell2232026781.331,6381,279,8121,330,598Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Ryan, Arthur F DirectSell7072026650.15200130,03011,249,545Form
2Ryan, Arthur F DirectSell5042026705.2410070,52412,343,781Form
3Ryan, Arthur FDirectSell4032026777.2710077,72713,682,333Form
4Ryan, Arthur F DirectSell3032026785.5010078,55013,905,627Form
5Zoghbi, Huda Y DirectSell2232026781.331,6381,279,8121,330,598Form
6Pitofsky, JasonSVP ControllerDirectSell2112026778.522,0361,585,0583,325,819Form
7Ryan, Arthur F DirectSell2112026778.5310077,85313,860,098Form
8Bassler, Bonnie L DirectSell11242025750.00760570,0001,161,000Form
9Pitofsky, JasonVP ControllerDirectSell11102025651.43431280,7662,757,503Form
10Poon, Christine A DirectSell10312025654.276,5004,252,7451,538,840Form

Investor Activity (13F)

Updated Jul 31, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Bronte Capital Management Pty Ltd.$133.5 Mil14.2%51Hold13F
Mcdonald Capital Investors Inc/Ca$159.1 Mil10.9%21Hold13F
Davern Capital Partners, LP$34.6 Mil9.5%17TRIM -14.5%13F
Jia Investment Alliance PTE. LTD.$52.0 Mil5.4%24Hold13F
Sound Shore Management Inc /CT/$116.6 Mil3.9%40TRIM -14.2%13F
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQAs OfFiling
Catalio Capital Management, LP$23.0 Mil4.1%45ExitedDec 31, 202513F
Sector Gamma AS$5.5 Mil1.3%36ExitedDec 31, 202513F
Davern Capital Partners, LP$34.6 Mil9.5%17TRIM -14.5%Mar 31, 202613F
Sound Shore Management Inc /CT/$116.6 Mil3.9%40TRIM -14.2%Mar 31, 202613F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Mcdonald Capital Investors Inc/Ca$159.1 Mil10.9%21Hold13F
Bronte Capital Management Pty Ltd.$133.5 Mil14.2%51Hold13F
Sound Shore Management Inc /CT/$116.6 Mil3.9%40TRIM -14.2%13F
Jia Investment Alliance PTE. LTD.$52.0 Mil5.4%24Hold13F
Davern Capital Partners, LP$34.6 Mil9.5%17TRIM -14.5%13F
Core Cache Last Updated: 7/30/2026