Tearsheet

Lantheus (LNTH)


Market Price (12/27/2025): $66.7 | Market Cap: $4.5 Bil
Sector: Health Care | Industry: Health Care Supplies

Lantheus (LNTH)


Market Price (12/27/2025): $66.7
Market Cap: $4.5 Bil
Sector: Health Care
Industry: Health Care Supplies

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 23%
Weak multi-year price returns
2Y Excs Rtn is -34%, 3Y Excs Rtn is -54%
Expensive valuation multiples
P/EPrice/Earnings or Price/(Net Income) is 27x
1 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 30%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%
Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
Key risks
LNTH key risks include [1] intensifying competition and pricing pressures eroding the market position of its flagship product, Show more.
2 Attractive yield
FCF Yield is 8.5%
  
3 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Personalized Diagnostics, Targeted Therapies, Show more.
  
0 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 23%
1 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 30%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%
2 Attractive yield
FCF Yield is 8.5%
3 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Personalized Diagnostics, Targeted Therapies, Show more.
4 Weak multi-year price returns
2Y Excs Rtn is -34%, 3Y Excs Rtn is -54%
5 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
6 Expensive valuation multiples
P/EPrice/Earnings or Price/(Net Income) is 27x
7 Key risks
LNTH key risks include [1] intensifying competition and pricing pressures eroding the market position of its flagship product, Show more.

Valuation, Metrics & Events

LNTH Stock


Why The Stock Moved


Qualitative Assessment

AI Analysis | Feedback

<b>1. Q3 2025 Financial Results and Outlook</b><br><br>

Lantheus reported third-quarter 2025 worldwide revenue of $384.0 million, surpassing analyst estimates. However, GAAP fully diluted earnings per share (EPS) significantly decreased to $0.41, a 77.1% drop from the prior year, and adjusted fully diluted EPS also declined to $1.27, a 25.3% decrease. Sales of PYLARIFY decreased by 7.4% to $240.6 million, while DEFINITY sales increased by 6.3% to $81.8 million. Despite the mixed earnings performance, the company reaffirmed its full-year 2025 revenue and adjusted EPS guidance, indicating confidence in its future outlook.

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<b>2. Leadership Transition</b><br><br>

On November 6, 2025, Lantheus announced a significant leadership transition plan. This included the upcoming retirement of CEO Brian Markison at year-end, the departure of the President, and the appointment of Mary Anne Heino, a former CEO, to the role of Executive Chairperson. The Board of Directors initiated a search for a new CEO.

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<b>3. Share Repurchase Program</b><br><br>

In the third quarter of 2025, Lantheus repurchased $100 million of its common stock. This action was part of a new share repurchase program, authorized by the board of directors on August 6, 2025, which allows for repurchases of up to $400 million of common stock through December 31, 2027, replacing a previous program.

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<b>4. Strategic Acquisition and Robust Pipeline Updates</b><br><br>

The acquisition of Life Molecular Imaging, completed in July 2025, was highlighted in the Q3 earnings report as a strategic move that immediately expanded Lantheus' near- and long-term growth profile and commercial portfolio. Furthermore, the company announced several significant pipeline advancements, including FDA acceptance of a New Drug Application (NDA) for a new formulation of its piflufolastat F 18 PSMA PET imaging agent, with a PDUFA date set for March 6, 2026. Lantheus also received PDUFA dates for MK-6240, its F 18 tau-targeted PET imaging agent, and LNTH-2501, a Ga 68 PET diagnostic imaging kit.

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<b>5. Positive Analyst Sentiment and Price Targets</b><br><br>

Throughout the period from August 2025 to December 2025, multiple Wall Street analysts maintained or upgraded their ratings for Lantheus. The consensus among analysts was generally a "Moderate Buy" or "Strong Buy," with an average price target indicating a potential upside in the stock price. For instance, in December 2025, Truist Securities upgraded Lantheus Holdings to a "Strong Buy" and Mizuho maintained an "Outperform" recommendation.

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Stock Movement Drivers

Fundamental Drivers

The 31.8% change in LNTH stock from 9/26/2025 to 12/26/2025 was primarily driven by a 109.0% change in the company's P/E Multiple.
926202512262025Change
Stock Price ($)50.6166.7131.81%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)1520.651525.930.35%
Net Income Margin (%)17.82%10.99%-38.34%
P/E Multiple12.8026.75109.03%
Shares Outstanding (Mil)68.5267.231.88%
Cumulative Contribution31.77%

LTM = Last Twelve Months as of date shown

Market Drivers

9/26/2025 to 12/26/2025
ReturnCorrelation
LNTH31.8% 
Market (SPY)4.3%16.7%
Sector (XLV)15.2%37.2%

Fundamental Drivers

The -18.1% change in LNTH stock from 6/27/2025 to 12/26/2025 was primarily driven by a -33.6% change in the company's Net Income Margin (%).
627202512262025Change
Stock Price ($)81.4966.71-18.14%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)1536.701525.93-0.70%
Net Income Margin (%)16.55%10.99%-33.60%
P/E Multiple22.0026.7521.55%
Shares Outstanding (Mil)68.6767.232.10%
Cumulative Contribution-18.17%

LTM = Last Twelve Months as of date shown

Market Drivers

6/27/2025 to 12/26/2025
ReturnCorrelation
LNTH-18.1% 
Market (SPY)12.6%-0.5%
Sector (XLV)17.0%30.2%

Fundamental Drivers

The -28.5% change in LNTH stock from 12/26/2024 to 12/26/2025 was primarily driven by a -61.5% change in the company's Net Income Margin (%).
1226202412262025Change
Stock Price ($)93.2566.71-28.46%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)1496.801525.931.95%
Net Income Margin (%)28.57%10.99%-61.54%
P/E Multiple15.1526.7576.57%
Shares Outstanding (Mil)69.4667.233.22%
Cumulative Contribution-28.54%

LTM = Last Twelve Months as of date shown

Market Drivers

12/26/2024 to 12/26/2025
ReturnCorrelation
LNTH-28.5% 
Market (SPY)15.8%16.5%
Sector (XLV)13.3%23.9%

Fundamental Drivers

The 35.9% change in LNTH stock from 12/27/2022 to 12/26/2025 was primarily driven by a 90.4% change in the company's Total Revenues ($ Mil).
1227202212262025Change
Stock Price ($)49.1066.7135.87%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)801.461525.9390.39%
Net Income Margin (%)13.36%10.99%-17.72%
P/E Multiple31.5426.75-15.20%
Shares Outstanding (Mil)68.7667.232.22%
Cumulative Contribution35.80%

LTM = Last Twelve Months as of date shown

Market Drivers

12/27/2023 to 12/26/2025
ReturnCorrelation
LNTH8.5% 
Market (SPY)48.0%13.4%
Sector (XLV)18.2%21.4%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
LNTH Return-34%114%76%22%44%-25%225%
Peers Return16%38%-12%21%26%16%150%
S&P 500 Return16%27%-19%24%23%18%114%

Monthly Win Rates [3]
LNTH Win Rate42%75%58%67%67%67% 
Peers Win Rate52%65%42%68%57%52% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
LNTH Max Drawdown-56%0%-16%-6%-18%-44% 
Peers Max Drawdown-34%-5%-26%-7%-9%-23% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: HPQ, HPE, IBM, CSCO, AAPL.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/26/2025 (YTD)

How Low Can It Go

Unique KeyEventLNTHS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-44.8%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven81.3%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven94 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-55.6%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven125.1%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven377 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-47.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven91.6%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven140 days120 days

Compare to HPQ, HPE, IBM, CSCO, AAPL

In The Past

Lantheus's stock fell -44.8% during the 2022 Inflation Shock from a high on 8/25/2022. A -44.8% loss requires a 81.3% gain to breakeven.

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About Lantheus (LNTH)

Lantheus Holdings, Inc. develops, manufactures, and commercializes diagnostic and therapeutic products that assist clinicians in the diagnosis and treatment of heart, cancer, and other diseases worldwide. It provides DEFINITY, a microbubble ultrasound enhancing agent used in ultrasound exams of the heart; TechneLite, a technetium generator for nuclear medicine; Xenon-133 to assess pulmonary function; Neurolite to identify the area within the brain where blood flow has been blocked or reduced due to stroke; Cardiolite, an injectable Tc-99m-labeled imaging agent; Thallium-201 to detect cardiovascular disease; and Gallium-67 to detect various infections and cancerous tumors. The company also offers AZEDRA, a radiotherapeutic to treat adult and pediatric patients; Automated Bone Scan Index that calculates the disease burden of prostate cancer by quantifying the hotspots on bone scans; and Cobalt (Co 57), a non-pharmaceutical radiochemical; RELISTOR for opioid-induced constipation; and PYLARIFY for visualization of lymph nodes, bone, and soft tissue metastases to determine the presence or absence of recurrent and/or metastatic prostate cancer. It also develops flurpiridaz F 18 to assess blood flow to the heart; 1095, a PSMA-targeted iodine-131 labeled small molecule; LMI 1195 for neuroblastoma tumors in pediatric and adults; PYLARIFY AI, an AI-based medical device software to perform standardized quantitative assessment of PSMA PET/CT images in prostate cancer; and leronlimab, an investigational humanized monoclonal antibody. The company serves radio pharmacies, distributors, integrated delivery networks, hospitals, clinics, and group practices. It has strategic partnerships with NanoMab Technology Limited; Bausch Health Companies, Inc.; GE Healthcare Limited; Curium; Bayer AG; CytoDyn Inc.; ROTOP; FUJIFILM; Regeneron Pharmaceuticals, Inc.; and POINT Biopharma US Inc. The company was founded in 1956 and is headquartered in North Billerica, Massachusetts.

AI Analysis | Feedback

Here are 1-2 brief analogies to describe Lantheus (LNTH):

  • Like a specialized, standalone version of Novartis's radiopharmaceutical business, focused on developing radioactive compounds for both advanced medical imaging and targeted cancer therapies.

  • Exact Sciences (known for Cologuard), but focused on creating advanced injectable imaging agents that light up cancers for precise diagnosis, particularly prostate cancer.

AI Analysis | Feedback

  • PYLARIFY®: An advanced PET imaging agent used for detecting and staging prostate cancer.
  • DEFINITY®: An ultrasound enhancing agent that improves visualization of the left ventricular endocardial border in echocardiograms.
  • TECHNETIUM 99M Generators: Devices that produce Technetium 99m, a widely used radioisotope for various diagnostic nuclear medicine procedures.
  • AZEDRA®: A targeted radiotherapeutic agent for specific rare neuroendocrine tumors.
  • XENON-133: A diagnostic radioactive gas primarily used for lung ventilation imaging studies.

AI Analysis | Feedback

Lantheus (symbol: LNTH) primarily sells its products to other companies rather than directly to individuals.

According to its most recent annual report (10-K), Lantheus states that no single customer accounted for more than 10% of its consolidated net revenue in 2023, 2022, or 2021. This indicates a diversified customer base and means that there are no individually "major customer companies" that are required to be disclosed by name in its public filings as exceeding a significant percentage of total revenue.

Therefore, instead of specific named companies that represent a dominant share of revenue, Lantheus's major customers can be described by the following categories of organizations that purchase and utilize its radiopharmaceutical products:

  • Hospitals and Health Systems: These are primary institutional customers where Lantheus's diagnostic imaging agents and targeted radiotherapeutics are administered to patients.
  • Diagnostic Imaging Centers and Clinics: Specialized outpatient facilities focused on medical imaging, including PET (Positron Emission Tomography) scans, which utilize Lantheus products like PYLARIFY.
  • Pharmaceutical Wholesalers and Distributors: These companies serve as intermediaries, purchasing products directly from Lantheus and then distributing them to the aforementioned hospitals, health systems, and imaging centers. Major players in this sector include Cencora (formerly AmerisourceBergen) (Symbol: COR), Cardinal Health (Symbol: CAH), and McKesson Corporation (Symbol: MCK). While these are key direct corporate customers in the supply chain, as noted, no single one represents a "major customer" in terms of exceeding 10% of Lantheus's total revenue.

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Jubilant Pharmova Limited (NSE: JUBLPHARMA)

NRG

Australian Nuclear Science and Technology Organisation (ANSTO)

ITM Isotope Technologies Munich SE

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Mary Anne Heino, Executive Chairperson and Interim Chief Executive Officer

Mary Anne Heino has served as Executive Chairperson of Lantheus since November 7, 2025, and will lead the company as interim CEO following the retirement of Brian Markison at the end of 2025. She previously held the role of CEO of Lantheus from August 2015 to March 2024, and was also President during part of that period. During her tenure as CEO, she led the acquisition of Progenics and spearheaded the development and commercialization of a leading PSMA-targeted PET imaging agent for prostate cancer. She joined Lantheus in April 2013 as Chief Commercial Officer and was promoted to Chief Operating Officer in March 2015. Prior to Lantheus, Ms. Heino held senior commercial and strategic leadership roles at Angelini Labopharm LLC and Labopharm USA (2007-2012), and Centocor, Inc., a Johnson & Johnson company (2000-2007). She began her professional career in sales and marketing at Janssen Pharmaceutica, another Johnson & Johnson company.

Robert J. Marshall Jr., Chief Financial Officer and Treasurer

Robert J. Marshall Jr. serves as the Chief Financial Officer and Treasurer of Lantheus. He has also served as Chief Financial Officer and Treasurer of Lantheus Medical Imaging.

Daniel Niedzwiecki, Chief Administrative Officer, General Counsel & Corporate Secretary

Daniel Niedzwiecki serves as Chief Administrative Officer, General Counsel, and Corporate Secretary at Lantheus. He was appointed Chief Administrative Officer in March 2023, General Counsel in April 2021, and Corporate Secretary in April 2019.

Amanda Morgan, Chief Commercial Officer

Amanda Morgan serves as the Chief Commercial Officer for Lantheus, a role she returned to after a leave of absence, reporting directly to Mary Anne Heino.

Jean-Claude Provost, Chief Medical Officer

Jean-Claude Provost serves as the Chief Medical Officer at Lantheus.

AI Analysis | Feedback

The key risks to Lantheus's business are primarily centered around its reliance on its flagship product, increasing market competition, and challenges related to recent strategic acquisitions.

  1. Product Concentration and Intensifying Competition for PYLARIFY: Lantheus's financial health is heavily dependent on PYLARIFY, its prostate cancer imaging agent, which is the main revenue driver. Sales of PYLARIFY have shown signs of slowing due to intensifying price competition in the PSMA PET imaging market. For instance, PYLARIFY sales dropped by 7.4% in Q3 2025, indicating significant market pressure. Analysts have lowered their price targets on Lantheus due to "Pylarify pricing pressures" and "competitive share loss risks". The entry of generic competitors post-2026 could further exacerbate competition, impacting market share and revenue. There is also an ongoing class action lawsuit alleging that Lantheus misled investors by not fully disclosing the pricing risks for PYLARIFY, which reportedly led to erosion of its market position.
  2. Acquisition Integration and Pipeline Development Challenges: Lantheus has undertaken strategic acquisitions, such as Evergreen Theragnostics and Life Molecular Imaging (which includes the Alzheimer's diagnostic Neuraceq®), to diversify its revenue streams. However, integrating these new businesses and their associated costs is expected to strain resources and management focus in the short term. Such acquisitions inherently carry operational and financial risks, including the potential for reduced financial resources, the incurrence of substantial debt, and difficulties in effectively combining operations and retaining key personnel. While these diversification efforts are crucial, they are projected to yield only low-single-digit earnings per share accretion in the near term, with integration and potential dilution risks remaining.
  3. Leadership Transition: The impending retirement of Lantheus's CEO at the end of 2025 introduces an element of uncertainty. This leadership change comes at a critical juncture for the company, as it navigates competitive pressures and seeks to integrate new acquisitions for future growth.

AI Analysis | Feedback

Emergence of next-generation alpha-emitting radioligand therapies (RLTs) for prostate cancer.

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Lantheus (symbol: LNTH) has several key products and services with identifiable addressable markets:

  • PYLARIFY (piflufolastat F 18): This is a PET radiotracer used for imaging prostate-specific membrane antigen (PSMA)-positive lesions in men with prostate cancer.
    • The U.S. addressable market for PYLARIFY is estimated at $1.6 billion.
    • The total addressable market for PSMA PET imaging agents for prostate cancer in the U.S. is projected to be over $2.5 billion in 2025, increasing from over $2 billion in 2024, and could surpass $3.5 billion by the end of the decade.
    • The global PSMA PET Imaging Market reached US$1.5 billion in 2022 and is expected to reach US$2 billion by 2030.
    • The U.S. prostate cancer nuclear medicine diagnostics market size was estimated at USD 75.06 million in 2022 and is expected to reach USD 153.97 million by 2030.
    • The current market potential for PSMA PET imaging agents in the U.S. for 2024 could be about 445,000 scans, with a total addressable market potentially exceeding 700,000 annual scans by 2029.
  • DEFINITY (Perflutren Lipid Microsphere) Injectable Suspension: This is an ultrasound enhancing agent primarily used in echocardiography procedures.
    • Lantheus holds over 80% of the U.S. market share for ultrasound enhancing agents in echocardiography procedures as of the end of 2023.
    • The global contrast-enhanced ultrasound market is projected to reach USD 2.1 billion by 2028, growing from USD 1.6 billion in 2023.
  • TechneLite (Technetium Tc 99m Generator): This product provides Technetium (Tc99m), a radioactive isotope essential for preparing various nuclear imaging agents.
    • Technetium-99m (Tc-99m) is used in over 40 million diagnostic procedures annually globally.
    • The global radiopharmaceuticals market, which includes TechneLite, was valued at US$ 6.8 billion in 2024 and is expected to reach US$ 13.4 billion by 2033.
    • The U.S. radiopharmaceuticals market was valued at USD 2.21 billion in 2024 and is estimated to reach USD 2.36 billion by 2033.
  • Alzheimer's Disease Diagnostics (including Neuraceq, MK-6240, and NAV-4694): These products are PET imaging agents for detecting beta-amyloid plaques and tau pathology in patients evaluated for Alzheimer's disease.
    • Lantheus anticipates a total addressable market size for Alzheimer's disease diagnostics of $1.5 billion globally in 2030 and $2.5 billion globally by mid-2030.
    • The U.S. Alzheimer's disease radiodiagnostic market is considered to have significant growth potential.
  • PNT2003: This is a therapeutic candidate for neuroendocrine tumors.
    • The addressable U.S. market for PNT2003 is approximately $1 billion and is expected to expand to over $5 billion by 2029.
    • The total addressable market for somatostatin NET PET diagnostics is estimated at $200 million or 50,000 patients per year.
  • AZEDRA (iobenguane I-131): This radiopharmaceutical was used for the treatment of pheochromocytoma and paraganglioma. Lantheus announced its discontinuation in August 2023 due to insufficient uptake and high manufacturing costs.

AI Analysis | Feedback

Lantheus (LNTH) is poised for future revenue growth over the next 2-3 years, driven by several key factors:

  1. Continued Growth and Market Expansion of PYLARIFY: PYLARIFY, a leading PSMA PET imaging agent for prostate cancer, achieved blockbuster status in 2024 with over $1 billion in sales and is expected to continue its growth trajectory. The addressable market for PSMA PET imaging is projected to expand significantly, reaching an estimated $2.5+ billion in 2025 and potentially exceeding $3.5 billion by the end of the decade. This growth is fueled by increasing patient volumes, the conversion from conventional imaging methods, broader adoption among healthcare providers, and strategic partnerships. Furthermore, a new formulation of PYLARIFY is expected to increase batch size by approximately 50%, allowing Lantheus to serve significantly more patients.
  2. Sustained Performance and Market Leadership of DEFINITY: DEFINITY, Lantheus's high-resolution echocardiogram enhancement agent, continues to demonstrate robust performance and maintain its strong market leadership in the ultrasound-enhancing agent market. Its consistent growth is driven by ongoing market expansion and opportunistic sales, partly due to competitor supply challenges.
  3. Expansion into Alzheimer's Diagnostics through Strategic Acquisitions and Pipeline: Lantheus is diversifying its portfolio by entering the Alzheimer's diagnostics market. The acquisition of Life Molecular Imaging brings Neuraceq, an approved radiodiagnostic for Alzheimer's disease, and enhances R&D capabilities in this area. Additionally, Lantheus has pipeline candidates like MK-6240 and NAV-4694, which are radio diagnostics for Alzheimer's disease, with regulatory submissions anticipated in 2025 and 2026, respectively.
  4. Entry into Neuroendocrine Tumors and Radioligand Therapy Manufacturing via Acquisitions: The acquisition of Evergreen Theragnostics adds OCTEVY, a registrational-stage PET imaging agent targeting neuroendocrine tumors, which complements Lantheus's therapeutic candidate PNT2003. This acquisition also provides Lantheus with radioligand therapy manufacturing infrastructure, including a revenue-generating contract development and manufacturing organization (CDMO) business, further diversifying its revenue streams.
  5. Favorable Regulatory Environment and Improved Reimbursement: A significant driver for future growth is the supportive regulatory environment, particularly the Centers for Medicare & Medicaid Services (CMS) decision to implement separate payment for diagnostic radiopharmaceuticals starting in 2025. This change is expected to improve patient access and foster innovation for products like PYLARIFY.

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Share Repurchases

  • In November 2024, Lantheus's board authorized a share repurchase program of up to $250 million.
  • This program was subsequently replaced in August 2025 with a new authorization for up to $400 million in share repurchases, valid through December 31, 2027.
  • Lantheus repurchased $100 million of its common stock in the third quarter of 2025, following approximately $100 million in repurchases during 2024.

Outbound Investments

  • In July 2025, Lantheus completed the acquisition of Life Molecular Imaging for approximately $309 million (net of cash acquired), which expanded its nuclear medicine commercial portfolio.
  • The company acquired Evergreen Theragnostics, Inc. for $276.4 million in April 2025, enhancing its radioligand manufacturing capabilities.
  • Lantheus made a strategic investment of approximately A$7.6 million (US$5 million) in Radiopharm Theranostics in October 2025 as part of a private placement.

Capital Expenditures

  • Capital expenditures were $10.6 million in the third quarter of 2025 and $8.0 million in the second quarter of 2025.
  • Annual capital expenditures were approximately $35.3 million in 2024, $27.3 million in 2023, and $15.8 million in 2022.
  • For the years 2021 and 2020, capital expenditures were approximately $11.2 million and $8.0 million, respectively.

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Peer Comparisons for Lantheus

Peers to compare with:

Financials

LNTHHPQHPEIBMCSCOAAPLMedian
NameLantheus HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Price66.7123.2624.49305.0978.16273.4072.44
Mkt Cap4.521.932.6284.9309.24,074.4158.8
Rev LTM1,52655,29534,29665,40257,696408,62556,496
Op Inc LTM3503,6241,64411,54412,991130,2147,584
FCF LTM3812,80062711,85412,73396,1847,327
FCF 3Y Avg3552,9781,40011,75313,879100,5037,366
CFO LTM4583,6972,91913,48313,744108,5658,590
CFO 3Y Avg4183,6723,89613,49814,736111,5598,697

Growth & Margins

LNTHHPQHPEIBMCSCOAAPLMedian
NameLantheus HP Hewlett .Internat.Cisco Sy.Apple  
Rev Chg LTM1.9%3.2%13.8%4.5%8.9%6.0%5.2%
Rev Chg 3Y Avg25.5%-3.9%6.5%2.6%3.7%1.8%3.2%
Rev Chg Q1.4%4.2%14.4%9.1%7.5%9.6%8.3%
QoQ Delta Rev Chg LTM0.3%1.1%3.7%2.1%1.8%2.1%2.0%
Op Mgn LTM22.9%6.6%4.8%17.7%22.5%31.9%20.1%
Op Mgn 3Y Avg19.7%7.4%7.2%16.4%24.2%30.8%18.1%
QoQ Delta Op Mgn LTM-6.0%-0.2%-1.4%0.6%0.4%0.1%-0.1%
CFO/Rev LTM30.0%6.7%8.5%20.6%23.8%26.6%22.2%
CFO/Rev 3Y Avg29.4%6.8%12.7%21.4%26.1%28.4%23.8%
FCF/Rev LTM24.9%5.1%1.8%18.1%22.1%23.5%20.1%
FCF/Rev 3Y Avg24.9%5.5%4.6%18.6%24.6%25.6%21.6%

Valuation

LNTHHPQHPEIBMCSCOAAPLMedian
NameLantheus HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Cap4.521.932.6284.9309.24,074.4158.8
P/S2.90.41.04.45.410.03.6
P/EBIT17.16.819.925.122.531.321.2
P/E26.78.6572.736.029.941.033.0
P/CFO9.85.911.221.122.537.516.2
Total Yield3.7%14.1%2.3%5.0%5.4%2.8%4.3%
Dividend Yield0.0%2.5%2.1%2.2%2.1%0.4%2.1%
FCF Yield 3Y Avg7.3%10.6%5.5%6.4%6.0%3.1%6.2%
D/E0.10.50.70.20.10.00.2
Net D/E0.10.30.60.20.00.00.1

Returns

LNTHHPQHPEIBMCSCOAAPLMedian
NameLantheus HP Hewlett .Internat.Cisco Sy.Apple  
1M Rtn13.5%-1.8%14.4%0.6%2.7%-1.5%1.7%
3M Rtn31.8%-11.9%2.7%7.9%17.0%7.1%7.5%
6M Rtn-18.1%-4.0%34.5%6.6%15.2%36.3%10.9%
12M Rtn-28.5%-27.3%14.2%39.2%33.7%6.0%10.1%
3Y Rtn35.9%-3.8%67.7%139.0%79.5%113.4%73.6%
1M Excs Rtn10.5%-5.6%12.9%-2.2%-0.0%-3.7%-1.1%
3M Excs Rtn27.5%-16.2%-1.7%3.6%12.7%2.8%3.2%
6M Excs Rtn-30.4%-16.3%22.3%-5.7%3.0%24.0%-1.3%
12M Excs Rtn-42.7%-42.9%-0.7%25.0%19.9%-8.4%-4.6%
3Y Excs Rtn-53.9%-83.5%-11.2%59.6%-1.2%28.4%-6.2%

FDA Approved Drugs Data

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Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA021711  ABLAVARgadofosveset trisodiumsolution12222008     

Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
PYLARIFY85152743  
DEFINITY280245233196218
TechneLite8789918587
Strategic partnerships and other revenue52472512 
Other precision diagnostics23232737 
Other radiopharmaceutical oncology34510 
Other nuclear    60
Rebates and allowances    -17
Total1,296935425339347


Price Behavior

Price Behavior
Market Price$66.71 
Market Cap ($ Bil)4.5 
First Trading Date06/25/2015 
Distance from 52W High-39.4% 
   50 Days200 Days
DMA Price$58.70$71.41
DMA Trenddownup
Distance from DMA13.6%-6.6%
 3M1YR
Volatility37.2%56.1%
Downside Capture24.4348.82
Upside Capture152.468.19
Correlation (SPY)16.1%16.4%
LNTH Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta0.920.630.480.130.470.59
Up Beta0.931.551.870.490.660.56
Down Beta0.52-0.03-0.180.340.490.55
Up Capture145%114%50%-34%-1%20%
Bmk +ve Days13263974142427
Stock +ve Days10213164127384
Down Capture72%31%29%24%56%86%
Bmk -ve Days7162452107323
Stock -ve Days10213261121364

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of LNTH With Other Asset Classes (Last 1Y)
 LNTHSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-25.3%15.1%17.8%72.1%8.6%4.4%-8.3%
Annualized Volatility55.9%17.2%19.4%19.3%15.2%17.0%35.0%
Sharpe Ratio-0.290.650.722.700.340.09-0.08
Correlation With Other Assets 24.1%16.5%4.9%3.7%20.1%-2.0%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
 Comparison of LNTH With Other Asset Classes (Last 5Y)
 LNTHSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return35.3%8.4%14.7%18.7%11.5%4.6%30.8%
Annualized Volatility57.5%14.5%17.1%15.5%18.7%18.9%48.7%
Sharpe Ratio0.750.400.700.970.500.160.57
Correlation With Other Assets 25.3%26.6%6.5%9.4%27.2%8.1%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of LNTH With Other Asset Classes (Last 10Y)
 LNTHSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return34.1%9.9%14.8%15.3%7.0%5.3%69.2%
Annualized Volatility62.7%16.6%18.0%14.7%17.6%20.8%55.8%
Sharpe Ratio0.730.490.710.860.320.220.90
Correlation With Other Assets 29.9%31.7%2.6%13.9%29.1%7.5%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date12152025
Short Interest: Shares Quantity7,157,474
Short Interest: % Change Since 113020251.0%
Average Daily Volume1,154,956
Days-to-Cover Short Interest6.20
Basic Shares Quantity67,230,000
Short % of Basic Shares10.6%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/6/2025-6.2%-4.8%8.8%
8/6/2025-28.6%-25.8%-25.9%
5/7/2025-23.2%-24.7%-23.4%
1/28/2025-7.3%-8.9%-5.1%
11/6/2024-20.7%-25.9%-22.3%
7/31/2024-4.5%-10.6%-0.1%
5/2/202416.0%10.6%21.4%
2/22/202414.7%15.3%3.5%
...
SUMMARY STATS   
# Positive8911
# Negative131210
Median Positive14.8%15.3%8.8%
Median Negative-6.7%-13.2%-16.8%
Max Positive39.1%81.6%76.5%
Max Negative-28.6%-25.9%-27.2%

SEC Filings

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Report DateFiling DateFiling
93020251106202510-Q 9/30/2025
6302025806202510-Q 6/30/2025
3312025507202510-Q 3/31/2025
12312024226202510-K 12/31/2024
93020241106202410-Q 9/30/2024
6302024731202410-Q 6/30/2024
3312024502202410-Q 3/31/2024
12312023222202410-K 12/31/2023
93020231102202310-Q 9/30/2023
6302023803202310-Q 6/30/2023
3312023504202310-Q 3/31/2023
12312022223202310-K 12/31/2022
93020221103202210-Q 9/30/2022
6302022804202210-Q 6/30/2022
3312022429202210-Q 3/31/2022
12312021224202210-K 12/31/2021