Halozyme Therapeutics (HALO)


Market Price (7/26/2026): $82.21 | Market Cap: $9.7 BilSector: Health Care | Industry: Biotechnology

Halozyme Therapeutics (HALO)


Market Price (7/26/2026): $82.21
Market Cap: $9.7 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 39%

Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 56%

Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 45%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%

Low stock price volatility
Vol 12M is 31%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.

Trading close to highs
Dist 52W High is 0.0%, Dist 3Y High is 0.0%

Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%

Key risks
HALO key risks include [1] the 2027 patent expiration of its core ENHANZE technology, Show more.

0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 39%
1 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 56%
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 45%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 25%
3 Low stock price volatility
Vol 12M is 31%
4 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.
5 Trading close to highs
Dist 52W High is 0.0%, Dist 3Y High is 0.0%
6 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
7 Key risks
HALO key risks include [1] the 2027 patent expiration of its core ENHANZE technology, Show more.

HALO in ETFs

Weight = HALO's share of each fund

VTI0.01%
ITOT0.01%
IWB0.01%
IJH0.26%
VB0.11%
XBI1.1%
IBB0.71%
MDYG0.51%
+21 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 7/23/2026

Halozyme Therapeutics (HALO) stock has gained about 25% since 3/31/2026 because of the following key factors:

1. Robust Financial Performance in Fiscal Q1 2026.

Halozyme Therapeutics reported strong fiscal Q1 2026 results on May 11, 2026, significantly beating analyst expectations. The company announced earnings per share (EPS) of $1.60, surpassing the consensus estimate of $1.54 by $0.06. Quarterly revenue increased by 42.2% year-over-year to $376.71 million, exceeding analysts' expectations of $358.60 million. Following this announcement, the stock surged 8.1% on May 12, 2026. The company also reaffirmed its full-year 2026 financial guidance, projecting total revenue of $1.71 billion to $1.81 billion and royalty revenue of $1.13 billion to $1.17 billion, indicating confidence in continued growth.

2. Expansion of Drug Delivery Technology Through Multiple New Collaborations.

Halozyme secured several new global collaboration and licensing agreements for its ENHANZE® and Hypercon™ drug delivery technologies, demonstrating expanding interest and application. On July 20, 2026, Halozyme announced a collaboration with Incyte to utilize ENHANZE® for subcutaneous formulations of Incyte's INCA033989, a monoclonal antibody for myeloproliferative neoplasms, including an upfront payment, potential milestones, and royalties. This followed agreements in May 2026 with GSK for ENHANZE® across multiple oncology targets, including antibody-drug conjugates, and with Oruka Therapeutics for Hypercon™ technology. In April 2026, a collaboration with Vertex Pharmaceuticals was established, granting access to Hypercon™ technology for up to three targets with a $15 million upfront payment.

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Updated on 7/23/2026

Halozyme Therapeutics (HALO) stock has gained about 25% since 3/31/2026 because of the following key factors:

1. Robust Financial Performance in Fiscal Q1 2026.

Halozyme Therapeutics reported strong fiscal Q1 2026 results on May 11, 2026, significantly beating analyst expectations. The company announced earnings per share (EPS) of $1.60, surpassing the consensus estimate of $1.54 by $0.06. Quarterly revenue increased by 42.2% year-over-year to $376.71 million, exceeding analysts' expectations of $358.60 million. Following this announcement, the stock surged 8.1% on May 12, 2026. The company also reaffirmed its full-year 2026 financial guidance, projecting total revenue of $1.71 billion to $1.81 billion and royalty revenue of $1.13 billion to $1.17 billion, indicating confidence in continued growth.

2. Expansion of Drug Delivery Technology Through Multiple New Collaborations.

Halozyme secured several new global collaboration and licensing agreements for its ENHANZE® and Hypercon™ drug delivery technologies, demonstrating expanding interest and application. On July 20, 2026, Halozyme announced a collaboration with Incyte to utilize ENHANZE® for subcutaneous formulations of Incyte's INCA033989, a monoclonal antibody for myeloproliferative neoplasms, including an upfront payment, potential milestones, and royalties. This followed agreements in May 2026 with GSK for ENHANZE® across multiple oncology targets, including antibody-drug conjugates, and with Oruka Therapeutics for Hypercon™ technology. In April 2026, a collaboration with Vertex Pharmaceuticals was established, granting access to Hypercon™ technology for up to three targets with a $15 million upfront payment.

3. Initiation of a Significant Share Repurchase Program.

Concurrent with its Q1 2026 earnings report, Halozyme announced a new $1 billion share repurchase program on May 11, 2026. The company stated its intention to repurchase at least $400 million in 2026. This move signals strong cash generation and management's confidence in the intrinsic value and long-term durability of Halozyme's business, which can be a significant positive catalyst for stock price appreciation.

4. Positive Analyst Sentiment and Upgraded Price Targets.

Analyst firms maintained a generally positive outlook on Halozyme, with several reiterating "Buy" ratings and setting optimistic price targets. For instance, HC Wainwright reiterated a Buy rating and set a $95 price target for HALO on July 21, 2026, suggesting a potential upside of 23.23% from the previous close. Analysts' consensus recommendation for HALO is "Buy," with an average 12-month price target of $87.15 among 16 analysts. This sustained positive sentiment from the investment community likely contributed to the upward trend.

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Stock Movement Drivers

Fundamental Drivers

The 26.8% change in HALO stock from 3/31/2026 to 7/25/2026 was primarily driven by a 15.6% change in the company's P/E Multiple.
(LTM values as of)33120267252026Change
Stock Price ($)64.6381.9326.8%
Change Contribution By: 
Total Revenues ($ Mil)1,3971,5088.0%
Net Income Margin (%)22.7%23.1%1.9%
P/E Multiple24.027.715.6%
Shares Outstanding (Mil)118118-0.4%
Cumulative Contribution26.8%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2026 to 7/25/2026
ReturnCorrelation
HALO26.8% 
Market (SPY)13.6%11.6%
Sector (XLV)10.9%55.4%

Fundamental Drivers

The 21.7% change in HALO stock from 12/31/2025 to 7/25/2026 was primarily driven by a 109.5% change in the company's P/E Multiple.
(LTM values as of)123120257252026Change
Stock Price ($)67.3081.9321.7%
Change Contribution By: 
Total Revenues ($ Mil)1,2431,50821.4%
Net Income Margin (%)47.9%23.1%-51.7%
P/E Multiple13.227.7109.5%
Shares Outstanding (Mil)117118-0.8%
Cumulative Contribution21.7%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 7/25/2026
ReturnCorrelation
HALO21.7% 
Market (SPY)8.7%23.9%
Sector (XLV)5.5%52.2%

Fundamental Drivers

The 57.5% change in HALO stock from 6/30/2025 to 7/25/2026 was primarily driven by a 110.1% change in the company's P/E Multiple.
(LTM values as of)63020257252026Change
Stock Price ($)52.0281.9357.5%
Change Contribution By: 
Total Revenues ($ Mil)1,0841,50839.1%
Net Income Margin (%)44.8%23.1%-48.3%
P/E Multiple13.227.7110.1%
Shares Outstanding (Mil)1231184.3%
Cumulative Contribution57.5%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2025 to 7/25/2026
ReturnCorrelation
HALO57.5% 
Market (SPY)20.6%22.3%
Sector (XLV)22.2%46.0%

Fundamental Drivers

The 127.1% change in HALO stock from 6/30/2023 to 7/25/2026 was primarily driven by a 114.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)63020237252026Change
Stock Price ($)36.0781.93127.1%
Change Contribution By: 
Total Revenues ($ Mil)7051,508114.0%
Net Income Margin (%)25.8%23.1%-10.2%
P/E Multiple26.827.73.5%
Shares Outstanding (Mil)13511814.3%
Cumulative Contribution127.1%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2023 to 7/25/2026
ReturnCorrelation
HALO127.1% 
Market (SPY)72.6%25.8%
Sector (XLV)28.2%42.2%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
HALO Return-6%42%-35%29%41%20%89%
Peers Return37%-2%25%-7%-4%4%55%
S&P 500 Return27%-19%24%23%16%8%97%

Monthly Win Rates [3]
HALO Win Rate42%58%33%50%58%57% 
Peers Win Rate67%48%50%45%50%51% 
S&P 500 Win Rate75%42%67%75%67%43% 

Max Drawdowns [4]
HALO Max Drawdown-38%-26%-47%-34%-32%-24% 
Peers Max Drawdown-15%-32%-28%-25%-33%-23% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: ABBV, PFE, BDX, WST, AMPH.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 7/24/2026 (YTD)

How Low Can It Go

EventHALOS&P 500
2025 US Tariff Shock
  % Loss-17.1%-18.8%
  % Gain to Breakeven20.6%23.1%
  Time to Breakeven63 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-22.2%-9.5%
  % Gain to Breakeven28.5%10.5%
  Time to Breakeven197 days24 days
2023 SVB Regional Banking Crisis
  % Loss-38.3%-6.7%
  % Gain to Breakeven62.2%7.1%
  Time to Breakeven395 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-22.1%-24.5%
  % Gain to Breakeven28.4%32.4%
  Time to Breakeven64 days427 days
2020 COVID-19 Crash
  % Loss-34.3%-33.7%
  % Gain to Breakeven52.3%50.9%
  Time to Breakeven35 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-28.6%-19.2%
  % Gain to Breakeven40.0%23.8%
  Time to Breakeven326 days105 days

Compare to ABBV, PFE, BDX, WST, AMPH

In The Past

Halozyme Therapeutics's stock fell -17.1% during the 2025 US Tariff Shock. Such a loss loss requires a 20.6% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

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EventHALOS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-22.2%-9.5%
  % Gain to Breakeven28.5%10.5%
  Time to Breakeven197 days24 days
2023 SVB Regional Banking Crisis
  % Loss-38.3%-6.7%
  % Gain to Breakeven62.2%7.1%
  Time to Breakeven395 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-22.1%-24.5%
  % Gain to Breakeven28.4%32.4%
  Time to Breakeven64 days427 days
2020 COVID-19 Crash
  % Loss-34.3%-33.7%
  % Gain to Breakeven52.3%50.9%
  Time to Breakeven35 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-28.6%-19.2%
  % Gain to Breakeven40.0%23.8%
  Time to Breakeven326 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-33.0%-3.7%
  % Gain to Breakeven49.2%3.9%
  Time to Breakeven9 days6 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-63.7%-12.2%
  % Gain to Breakeven175.7%13.9%
  Time to Breakeven672 days62 days
2014-2016 Oil Price Collapse
  % Loss-24.5%-6.8%
  % Gain to Breakeven32.5%7.3%
  Time to Breakeven23 days15 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-21.1%-17.9%
  % Gain to Breakeven26.7%21.8%
  Time to Breakeven71 days123 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-27.4%-15.4%
  % Gain to Breakeven37.7%18.2%
  Time to Breakeven507 days125 days
2008-2009 Global Financial Crisis
  % Loss-62.1%-53.4%
  % Gain to Breakeven163.5%114.4%
  Time to Breakeven180 days1085 days
Summer 2007 Credit Crunch
  % Loss-22.5%-8.6%
  % Gain to Breakeven29.0%9.5%
  Time to Breakeven33 days47 days

Compare to ABBV, PFE, BDX, WST, AMPH

In The Past

Halozyme Therapeutics's stock fell -17.1% during the 2025 US Tariff Shock. Such a loss loss requires a 20.6% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Halozyme Therapeutics (HALO)

Halozyme Therapeutics, Inc. is a biopharma technology platform company specializing in enhancing the delivery of injectable drugs. Its core innovation is the proprietary ENHANZE drug delivery technology, which utilizes a recombinant human hyaluronidase enzyme (rHuPH20). This technology allows for the subcutaneous (under the skin) administration of various therapeutic molecules, including biologics like monoclonal antibodies, small molecules, and fluids, making injections more convenient and efficient for patients and healthcare providers.

While Halozyme offers Hylenex recombinant, a direct product of its rHuPH20 enzyme for facilitating subcutaneous fluid administration and drug dispersion, its primary business model revolves around licensing its ENHANZE technology. This technology is incorporated into numerous partner products, significantly expanding their market reach and patient convenience. Key examples include therapies such as Perjeta, RITUXAN HYCELA, MabThera SC, HYQVIA, Tecentriq, OCREVUS, DARZALEX, and nivolumab, used across a wide spectrum of diseases.

Halozyme's primary customers are leading global pharmaceutical and biotechnology companies, which license and integrate the ENHANZE technology into their own drug pipelines. These strategic collaborations include major players like F. Hoffmann-La Roche, Pfizer, Janssen Biotech, AbbVie, Eli Lilly and Company, and Bristol-Myers Squibb, among others. Through these partnerships, Halozyme's technology ultimately benefits patients worldwide suffering from conditions such as various cancers (e.g., non-Hodgkin lymphoma, CLL, non-small cell lung cancer, multiple myeloma), immunodeficiency disorders, multiple sclerosis, autoimmune diseases, and HIV.

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Here are 1-3 brief analogies for Halozyme Therapeutics (HALO):

  • The "Intel Inside" for injectable drugs.
  • Dolby Laboratories for drug administration.

AI Analysis | Feedback

  • ENHANZE Drug Delivery Technology: A patented recombinant human hyaluronidase enzyme (rHuPH20) that enables the subcutaneous delivery of injectable biologics, small molecules, and fluids.
  • Hylenex Recombinant: A formulation of rHuPH20 used to facilitate subcutaneous fluid administration and enhance the dispersion and absorption of other injected drugs.
  • Perjeta (subcutaneous formulation): A therapeutic biologic delivered subcutaneously for cancer treatment, enabled by ENHANZE technology through a partnership.
  • RITUXAN HYCELA / MabThera SC: Subcutaneous formulations for treating non-Hodgkin lymphoma and chronic lymphocytic leukemia, leveraging ENHANZE technology.
  • HYQVIA: A subcutaneous immunoglobulin treatment for immunodeficiency disorders, enhanced by ENHANZE for improved delivery.
  • DARZALEX (subcutaneous formulation): An injectable biologic in development for multiple myeloma and amyloidosis, utilizing ENHANZE for subcutaneous administration.

AI Analysis | Feedback

Halozyme Therapeutics (HALO) is a biopharma technology platform company that primarily sells its ENHANZE drug delivery technology through collaborations and licensing agreements with other pharmaceutical and biotech companies. Its major customers are these partner companies:

  • Roche (OTCQX: RHHBY)
  • Takeda Pharmaceutical Company Limited (NYSE: TAK)
  • Pfizer Inc. (NYSE: PFE)
  • Johnson & Johnson (NYSE: JNJ)
  • AbbVie, Inc. (NYSE: ABBV)
  • Eli Lilly and Company (NYSE: LLY)
  • Bristol-Myers Squibb Company (NYSE: BMY)
  • AstraZeneca (NASDAQ: AZN)
  • Argenx SE (NASDAQ: ARGX)
  • Amgen (NASDAQ: AMGN)
  • GSK (NYSE: GSK)

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Halozyme Therapeutics (HALO) Management Team:

Helen Torley, President and Chief Executive Officer

Dr. Helen Torley has served as President and Chief Executive Officer of Halozyme Therapeutics since January 2014. She is also a member of the company's Board of Directors. Prior to joining Halozyme, Dr. Torley was Executive Vice President and Chief Commercial Officer at Onyx Pharmaceuticals, a subsidiary of Amgen, where she was responsible for the successful launch of Kyprolis in the U.S. and oversaw the development and commercial collaboration with Bayer on Nexavar and Stivarga. She spent 14 years in various management positions at Amgen in the Nephrology and Bone Health Business Units. Before Amgen, she held senior positions at Bristol-Myers Squibb, including Regional Vice President of Cardiovascular and Metabolic Sales and Head of Cardiovascular Global Marketing. Dr. Torley began her industry career at Sandoz/Novartis, ultimately serving as Vice President of Medical Affairs. She has led multiple successful product launches throughout her career, including Kyprolis, Prolia, Sensipar, and Miacalcin. Dr. Torley initially practiced as a physician specializing in rheumatology after graduating from medical school.

David Ramsay, Interim Chief Financial Officer

David Ramsay has been appointed Interim Chief Financial Officer of Halozyme Therapeutics, effective March 23, 2026. He will oversee all financial operations while the company conducts a search for a permanent CFO. Mr. Ramsay brings over 30 years of strategic financial leadership experience across the biotechnology and life sciences sectors. He previously served as Halozyme's Chief Financial Officer from 2003 to 2009 and again from 2013 to 2015, during which time he played a key role in the company's evolution from a private enterprise to a billion-dollar public biopharmaceutical company. Before his current interim appointment, Mr. Ramsay was Senior Vice President and Chief Financial Officer of Bonti, Inc. until its sale to Allergan plc in October 2018.

Cortney Caudill, Senior Vice President and Chief Operating Officer

Cortney Caudill serves as the Senior Vice President and Chief Operating Officer at Halozyme Therapeutics. Further detailed background information beyond her title at Halozyme was not immediately available in the search results.

Mark Snyder, Senior Vice President, General Counsel, Chief Compliance Officer and Secretary

Mark Snyder holds the positions of Senior Vice President, General Counsel, Chief Compliance Officer, and Secretary at Halozyme Therapeutics. Further detailed background information beyond his titles at Halozyme was not immediately available in the search results.

Dimitrios Chondros, Senior Vice President, Chief Medical Officer

Dimitrios Chondros serves as Senior Vice President and Chief Medical Officer at Halozyme Therapeutics. Further detailed background information beyond his titles at Halozyme was not immediately available in the search results.

AI Analysis | Feedback

The key risks to Halozyme Therapeutics (HALO) include:

  1. Dependency on partner success and collaborations: Halozyme's business model heavily relies on its ENHANZE drug delivery technology being licensed to and successfully utilized by major pharmaceutical companies for their injectable biologics. The commercial success, regulatory approval, and continued development of partner drugs (such as Perjeta, RITUXAN HYCELA, Tecentriq, OCREVUS, and DARZALEX) are critical revenue drivers for Halozyme through royalties and milestones. Any clinical trial failures, regulatory hurdles, or lower-than-expected commercial performance of these partner products, or a decision by partners not to renew or expand existing collaborations, could significantly impact Halozyme's revenue and financial performance.
  2. Intellectual property protection and patent expiration: The core of Halozyme's technology platform is its patented recombinant human hyaluronidase enzyme (rHuPH20). The ability to maintain and enforce these patents, as well as the eventual expiration of key patents, poses a significant risk. Loss of patent protection could allow competitors to develop and commercialize similar technologies without licensing, thereby eroding Halozyme's competitive advantage and revenue streams.
  3. Competition from alternative drug delivery technologies: While ENHANZE offers a unique solution for subcutaneous drug delivery, the pharmaceutical landscape is dynamic. The emergence of new or improved alternative drug delivery methods, or even entirely new therapeutic modalities that reduce or eliminate the need for enhanced subcutaneous delivery, could diminish the demand for Halozyme's technology platform, affecting its market position and growth prospects.

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Halozyme Therapeutics' core offerings, including its ENHANZE drug delivery technology and Hylenex recombinant product, operate within significant global addressable markets.

The global hyaluronidase market, which includes recombinant human hyaluronidase (rHuPH20) like Halozyme's ENHANZE enzyme and Hylenex, was valued at over USD 1.8 billion in 2025 and is projected to reach USD 6.4 billion by the end of 2035, growing at a Compound Annual Growth Rate (CAGR) of 15.2% from 2026 to 2035. In 2026, this market is assessed at USD 2 billion.

The broader global subcutaneous drug delivery market, which Halozyme's ENHANZE technology facilitates by enabling the subcutaneous administration of biologics, is projected to grow from USD 34.9 billion in 2025 to USD 66.7 billion by 2035, at a CAGR of 6.7% over the forecast period.

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Halozyme Therapeutics (HALO) is projected to experience revenue growth over the next two to three years driven by several key factors. Here are the expected drivers of future revenue growth for Halozyme Therapeutics:
  • Continued Growth in ENHANZE® Royalty Revenue: Halozyme anticipates sustained and significant growth in royalty revenue from its ENHANZE® drug delivery technology, particularly from blockbuster partner products. Key contributors to this growth include DARZALEX SC (Janssen), Phesgo (Roche), and VYVGART Hytrulo (argenx), which have demonstrated strong sales uptake across various geographies. The company expects royalty revenue to exceed $1 billion in 2026, representing a 30% to 35% growth over 2025.
  • Expansion of the ENHANZE® Platform through New Collaborations: Halozyme is actively expanding its ENHANZE® platform by securing new collaboration and licensing agreements. In 2025, the company added three new collaboration and licensing agreements and gained one new target nomination from Roche. Halozyme plans to sign at least three new licensing agreements in 2026, including new ENHANZE collaborations, which will broaden the pipeline of ENHANZE-enabled products and future revenue streams.
  • Regulatory Approvals and Geographic Expansion of Partner Products: New regulatory approvals and expanded indications for ENHANZE®-enabled products in various markets are expected to fuel revenue growth. Recent examples include Janssen's global approvals for Rybrevant SC in the U.S., China, and Japan, and new indication approvals for DARZALEX Faspro. Furthermore, a new European patent for ENHANZE®, valid until 2029 for DARZALEX SC, helps secure ongoing royalty rates in the region.
  • Integration and Leverage of Acquired Drug Delivery Technologies: The acquisitions of Elektrofi's Hypercon™ technology and Surf Bio's hyperconcentration technology in 2025 are strategic moves to diversify and extend Halozyme's drug delivery portfolio. These technologies are anticipated to meaningfully expand the company's long-term royalty opportunity into the mid-2040s. Halozyme expects to sign one to two new Hypercon collaborations in 2026, further leveraging these new assets.
  • Growth in XYOSTED® Product Sales: While royalty revenue remains the primary driver, Halozyme also anticipates continued growth in product sales from its proprietary product, XYOSTED®. This contributes to the company's overall total revenue growth.

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Share Repurchases

  • Halozyme Therapeutics completed repurchases of 11,177,781 shares for a total of $592.37 million under a buyback plan announced on February 20, 2024.
  • In December 2021, Halozyme's Board of Directors authorized a new share repurchase program for up to $750 million of its outstanding common stock over three years.
  • Under this program, Halozyme entered into a new $250 million accelerated share repurchase (ASR) program in January 2025, with another $250 million share repurchase announced in May 2025.

Share Issuance

  • Halozyme Therapeutics has primarily been repurchasing shares rather than issuing them, as evidenced by a net issuance of common stock amounting to -$571.1 million based on the financial report for September 30, 2025.
  • The company's shares outstanding have consistently declined year-over-year, including a 6% decline for the quarter ending September 30, 2025, and a 3.56% decline in 2024.

Inbound Investments

  • No information regarding large, one-off inbound investments by third-parties, such as strategic equity investments or private equity firm stakes in Halozyme Therapeutics, was found over the last 3-5 years. Halozyme's business model includes upfront licensing fees, milestone payments, and royalties from collaborative agreements, which are part of its operating revenue.

Outbound Investments

  • While Halozyme's capital allocation strategy includes potential mergers and acquisitions (M&A) to expand its platform, no significant outbound investments or acquisitions by Halozyme Therapeutics have been reported in the last 3-5 years.

Capital Expenditures

  • Halozyme Therapeutics's Capital Expenditures amounted to -$294.7 million for its fiscal year ending December 31, 2025.
  • Capital expenditures in the most recent quarter (Q4 2025) totaled -$3.03 million USD.
  • The company's FY2026 adjusted EBITDA outlook includes an investment of approximately $60 million in new initiatives such as Hypercon and Surf Bio, indicating a focus on expanding business operations and revenue base.

Better Bets vs. Halozyme Therapeutics (HALO)

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Peer Comparisons

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Financials

HALOABBVPFEBDXWSTAMPHMedian
NameHalozyme.AbbVie Pfizer Becton D.West Pha.Amphasta. 
Mkt Price81.93259.3624.54156.36328.2018.72119.15
Mkt Cap9.7459.1139.743.923.20.833.6
Rev LTM1,50862,81963,31421,3663,32772112,346
Op Inc LTM84620,84415,5083,0937231171,969
FCF LTM38019,9809,4833,0574371331,747
FCF 3Y Avg43319,0858,6032,8953791481,664
CFO LTM67721,22411,9843,8316621692,254
CFO 3Y Avg53720,10411,5173,6306971872,163

Growth & Margins

HALOABBVPFEBDXWSTAMPHMedian
NameHalozyme.AbbVie Pfizer Becton D.West Pha.Amphasta. 
Rev Chg LTM39.1%9.5%1.4%6.4%12.4%-1.4%8.0%
Rev Chg 3Y Avg29.1%3.6%-9.2%4.4%5.2%12.3%4.8%
Rev Chg Q42.2%12.4%5.4%5.2%13.8%0.4%8.9%
QoQ Delta Rev Chg LTM8.0%2.7%1.2%1.1%3.3%0.1%1.9%
Op Inc Chg LTM41.5%61.4%3.1%22.3%16.2%-40.0%19.2%
Op Inc Chg 3Y Avg51.1%12.1%203.9%8.2%1.6%9.8%10.9%
Op Mgn LTM56.1%33.2%24.5%14.5%21.7%16.2%23.1%
Op Mgn 3Y Avg51.7%26.9%17.3%13.2%21.3%24.7%23.0%
QoQ Delta Op Mgn LTM-1.4%0.3%-0.7%0.5%0.3%-3.3%-0.2%
CFO/Rev LTM44.9%33.8%18.9%17.9%19.9%23.4%21.7%
CFO/Rev 3Y Avg47.1%34.7%18.9%17.8%23.0%26.4%24.7%
FCF/Rev LTM25.2%31.8%15.0%14.3%13.1%18.4%16.7%
FCF/Rev 3Y Avg39.9%33.0%14.0%14.2%12.4%20.9%17.6%

Valuation

HALOABBVPFEBDXWSTAMPHMedian
NameHalozyme.AbbVie Pfizer Becton D.West Pha.Amphasta. 
Mkt Cap9.7459.1139.743.923.20.833.6
P/S6.47.32.22.17.01.24.3
P/Op Inc11.422.09.014.232.27.312.8
P/EBIT18.551.713.219.533.36.619.0
P/E27.7126.318.638.641.110.733.2
P/CFO14.321.611.711.535.15.013.0
Total Yield3.6%3.4%12.4%5.3%2.7%9.3%4.4%
Dividend Yield0.0%2.6%7.0%2.7%0.3%0.0%1.4%
FCF Yield 3Y Avg6.1%5.5%6.1%5.6%1.8%12.2%5.9%
D/E0.20.20.50.40.00.80.3
Net D/E0.20.10.40.4-0.00.50.3

Returns

HALOABBVPFEBDXWSTAMPHMedian
NameHalozyme.AbbVie Pfizer Becton D.West Pha.Amphasta. 
1M Rtn12.8%7.4%5.5%3.3%-5.3%-11.0%4.4%
3M Rtn25.4%31.5%-6.0%3.5%7.3%-12.6%5.4%
6M Rtn18.4%20.1%-1.0%-0.1%38.9%-27.8%9.1%
12M Rtn40.7%40.5%5.9%10.0%25.0%-16.3%17.5%
3Y Rtn87.3%102.7%-19.1%-25.4%-12.9%-69.5%-16.0%
1M Excs Rtn14.4%10.5%3.1%5.1%-4.3%-11.7%4.1%
3M Excs Rtn18.8%25.7%-9.1%-2.6%1.8%-15.2%-0.4%
6M Excs Rtn7.7%13.5%-8.3%-9.4%25.5%-35.6%-0.3%
12M Excs Rtn23.3%23.8%-11.2%-4.9%28.3%-33.8%9.2%
3Y Excs Rtn32.8%46.6%-79.8%-79.6%-76.6%-132.3%-78.1%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Research, development and commercialization of our proprietary enzymes and devices, Hypercon1,3971,015829  
Product sales, net   191104
Revenues under collaborative agreements   109135
Royalties   360204
Total1,3971,015829660443


Price Behavior

Price Behavior
Market Price$81.93 
Market Cap ($ Bil)9.7 
First Trading Date03/16/2004 
Distance from 52W High0.0% 
   50 Days200 Days
DMA Price$72.33$69.28
DMA Trendindeterminateup
Distance from DMA13.3%18.3%
 3M1YR
Volatility32.5%30.9%
Downside Capture-89.6412.33
Upside Capture31.7350.63
Correlation (SPY)3.0%22.1%
HALO Betas & Captures as of 6/30/2026

 1M2M3M6M1Y3Y
Beta0.400.260.580.710.610.69
Up Beta1.151.011.441.271.160.61
Down Beta1.021.160.770.700.560.81
Up Capture102%47%46%54%53%47%
Bmk +ve Days11244067140429
Stock +ve Days13233464135402
Down Capture-88%-117%-60%44%26%82%
Bmk -ve Days10172358112321
Stock -ve Days8182961116345

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with HALO
HALO40.1%30.8%1.11-
Sector ETF (XLV)20.9%15.7%1.0244.6%
Equity (SPY)17.6%12.7%1.0022.0%
Gold (GLD)19.2%28.1%0.6111.9%
Commodities (DBC)34.7%19.1%1.42-12.4%
Real Estate (VNQ)13.8%14.1%0.6925.8%
Bitcoin (BTCUSD)-46.2%42.9%-1.328.5%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with HALO
HALO14.1%39.4%0.44-
Sector ETF (XLV)6.4%15.0%0.2541.9%
Equity (SPY)12.8%17.1%0.5833.0%
Gold (GLD)17.0%18.4%0.754.1%
Commodities (DBC)9.6%19.5%0.381.3%
Real Estate (VNQ)3.0%18.9%0.0632.2%
Bitcoin (BTCUSD)15.3%53.4%0.4711.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with HALO
HALO25.1%42.5%0.67-
Sector ETF (XLV)10.0%16.6%0.4942.6%
Equity (SPY)14.9%17.9%0.7137.6%
Gold (GLD)11.3%16.1%0.574.5%
Commodities (DBC)7.2%17.9%0.329.3%
Real Estate (VNQ)5.2%20.7%0.2128.3%
Bitcoin (BTCUSD)58.1%66.2%0.987.1%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date7152026
Short Interest: Shares Quantity13.3 Mil
Short Interest: % Change Since 63020260.5%
Average Daily Volume1.8 Mil
Days-to-Cover Short Interest7.3 days
Basic Shares Quantity118.1 Mil
Short % of Basic Shares11.3%

Earnings Returns History

Updated 6/12/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
5/11/20266.8%1.6%6.2%
2/17/2026-9.0%-12.6%-20.9%
11/3/20252.8%2.7%-4.9%
8/5/20252.5%5.3%20.7%
5/6/202518.1%-15.4%-9.8%
2/18/2025-0.2%0.2%11.1%
10/31/202413.0%18.0%-3.9%
8/6/20244.2%7.8%17.5%
...
SUMMARY STATS   
# Positive181713
# Negative5610
Median Positive5.4%6.4%14.6%
Median Negative-1.6%-6.3%-9.7%
Max Positive18.1%31.6%43.2%
Max Negative-9.0%-15.4%-33.8%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
5/11/20266.8%1.6%6.2%
2/17/2026-9.0%-12.6%-20.9%
11/3/20252.8%2.7%-4.9%
8/5/20252.5%5.3%20.7%
5/6/202518.1%-15.4%-9.8%
2/18/2025-0.2%0.2%11.1%
10/31/202413.0%18.0%-3.9%
8/6/20244.2%7.8%17.5%
5/7/20241.9%6.3%24.8%
2/20/20246.6%10.7%12.2%
11/6/202310.0%6.4%13.4%
8/8/2023-1.6%1.6%-9.6%
5/9/202312.8%8.9%11.7%
2/21/20230.8%-3.4%-33.8%
11/8/20228.5%17.9%26.2%
8/9/20221.8%2.7%-8.4%
5/10/20221.0%16.4%17.7%
2/22/20222.9%8.7%14.6%
8/9/20212.0%2.1%4.0%
5/10/2021-7.4%-8.0%-14.6%
2/23/20219.0%-4.7%-12.1%
11/2/202011.3%31.6%43.2%
8/10/2020-1.5%-2.0%-2.1%
SUMMARY STATS   
# Positive181713
# Negative5610
Median Positive5.4%6.4%14.6%
Median Negative-1.6%-6.3%-9.7%
Max Positive18.1%31.6%43.2%
Max Negative-9.0%-15.4%-33.8%

SEC Filings

Expand for More
Report DateFiling DateFiling
03/31/202605/11/202610-Q
12/31/202502/17/202610-K
09/30/202511/03/202510-Q
06/30/202508/05/202510-Q
03/31/202505/06/202510-Q
12/31/202402/18/202510-K
09/30/202410/31/202410-Q
06/30/202408/06/202410-Q
03/31/202405/07/202410-Q
12/31/202302/20/202410-K
09/30/202311/06/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202202/21/202310-K
09/30/202211/08/202210-Q
06/30/202208/09/202210-Q
Collapse to Preview
Report DateFiling DateFiling
03/31/202605/11/202610-Q
12/31/202502/17/202610-K
09/30/202511/03/202510-Q
06/30/202508/05/202510-Q
03/31/202505/06/202510-Q
12/31/202402/18/202510-K
09/30/202410/31/202410-Q
06/30/202408/06/202410-Q
03/31/202405/07/202410-Q
12/31/202302/20/202410-K
09/30/202311/06/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202202/21/202310-K
09/30/202211/08/202210-Q
06/30/202208/09/202210-Q
03/31/202205/10/202210-Q
12/31/202102/22/202210-K
09/30/202111/02/202110-Q
06/30/202108/09/202110-Q
03/31/202105/10/202110-Q
12/31/202002/23/202110-K
09/30/202011/02/202010-Q
06/30/202008/10/202010-Q
03/31/202005/11/202010-Q
12/31/201902/24/202010-K
09/30/201911/12/201910-Q
06/30/201908/06/201910-Q

Recent Forward Guidance

Updated 7/12/2026

Latest: Q1 2026 Earnings Reported 5/11/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Total Revenue1.71 Bil1.76 Bil1.81 Bil0 AffirmedGuidance: 1.76 Bil for 2026
2026 Royalty Revenue1.13 Bil1.15 Bil1.17 Bil0 AffirmedGuidance: 1.15 Bil for 2026
2026 Adjusted EBITDA1.12 Bil1.17 Bil1.21 Bil0 AffirmedGuidance: 1.17 Bil for 2026
2026 Non-GAAP Diluted EPS7.7588.250 AffirmedGuidance: 8 for 2026
2026 Share Repurchases 400.00 Mil    

Prior: Q4 2025 Earnings Reported 2/17/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Total Revenue1.71 Bil1.76 Bil1.81 Bil31.6% Higher NewActual: 1.34 Bil for 2025
2026 Royalty Revenue1.13 Bil1.15 Bil1.17 Bil32.9% Higher NewActual: 865.00 Mil for 2025
2026 Adjusted EBITDA1.12 Bil1.17 Bil1.21 Bil28.0% Higher NewActual: 910.00 Mil for 2025
2026 Non-GAAP Diluted EPS7.7588.2527.0% Higher NewActual: 6.3 for 2025
2026 Total Revenue Growth22.0%26.0%30.0%   
2026 Royalty Revenue Growth30.0%32.5%35.0%   
2026 Adjusted EBITDA Growth71.0%77.0%83.0%   
2026 Non-GAAP Diluted EPS Growth87.0%93.0%99.0%   

Q3 2025 Earnings Reported 11/3/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2025 Total Revenue1.30 Bil1.34 Bil1.38 Bil1.7% RaisedGuidance: 1.31 Bil for 2025
2025 Royalty Revenue850.00 Mil865.00 Mil880.00 Mil2.7% RaisedGuidance: 842.50 Mil for 2025
2025 Adjusted EBITDA885.00 Mil910.00 Mil935.00 Mil2.2% RaisedGuidance: 890.00 Mil for 2025
2025 Non-GAAP Diluted EPS6.16.36.51.6% RaisedGuidance: 6.2 for 2025

Insider Activity

Updated 7/9/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Torley, HelenPRESIDENT AND CEODirectSell709202679.771,923153,39161,242,985Form
2Connaughton, Bernadette DirectSell702202676.711,625124,6513,225,114Form
3Krishnan, Mahesh DirectSell630202675.007,304547,8001,084,650Form
4Torley, HelenPRESIDENT AND CEODirectSell603202669.0710,000690,65353,026,948Form
5Torley, HelenPRESIDENT AND CEODirectSell603202666.3920,0001,327,74550,970,818Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Torley, HelenPRESIDENT AND CEODirectSell709202679.771,923153,39161,242,985Form
2Connaughton, Bernadette DirectSell702202676.711,625124,6513,225,114Form
3Krishnan, Mahesh DirectSell630202675.007,304547,8001,084,650Form
4Torley, HelenPRESIDENT AND CEODirectSell603202669.0710,000690,65353,026,948Form
5Torley, HelenPRESIDENT AND CEODirectSell603202666.3920,0001,327,74550,970,818Form
6Torley, HelenPRESIDENT AND CEODirectSell603202667.5820,0001,351,61051,886,953Form
7Connaughton, Bernadette DirectSell602202666.211,625107,5912,891,324Form
8Torley, HelenPRESIDENT AND CEODirectSell513202669.1910,000691,90853,123,316Form
9Torley, HelenPRESIDENT AND CEODirectSell513202671.7520,0001,435,02755,089,250Form
10Torley, HelenPRESIDENT AND CEODirectSell513202665.3520,0001,306,94050,172,109Form
11Connaughton, Bernadette DirectSell505202663.481,625103,1552,443,853Form
12Torley, HelenPRESIDENT AND CEODirectSell407202663.5010,000634,98248,752,617Form
13Torley, HelenPRESIDENT AND CEODirectSell402202664.2420,0001,284,72149,319,147Form
14Torley, HelenPRESIDENT AND CEODirectSell402202665.3820,0001,307,51650,194,232Form
15Caudill, CortneySVP, CHIEF OPERATING OFFICERDirectSell310202667.648,857599,087477,200Form
16Caudill, CortneySVP, CHIEF OPERATING OFFICERDirectSell310202667.8020,0001,356,072974,067Form
17Torley, HelenPRESIDENT AND CEODirectSell304202670.2110,000702,11453,906,883Form
18Torley, HelenPRESIDENT AND CEODirectSell304202669.0120,0001,380,14952,982,528Form
19Torley, HelenPRESIDENT AND CEODirectSell304202669.6920,0001,393,89453,510,214Form
20Torley, HelenPRESIDENT AND CEODirectSell205202678.6410,000786,36655,731,222Form
21Torley, HelenPRESIDENT AND CEODirectSell205202677.2420,0001,544,82054,742,178Form
22Torley, HelenPRESIDENT AND CEODirectSell205202676.1220,0001,522,31753,944,759Form
23Connaughton, Bernadette DirectSell106202670.252,000140,5002,818,641Form
24Caudill, CortneySVP, CHIEF OPERATING OFFICERDirectSell1219202565.194,263277,905830,325Form
25Connaughton, Bernadette DirectSell1201202571.6082959,3563,016,007Form
26Torley, HelenPRESIDENT AND CEODirectSell1201202568.9216,5691,141,92548,844,455Form
27Torley, HelenPRESIDENT AND CEODirectSell1112202570.5520,0001,410,99051,763,526Form
28Torley, HelenPRESIDENT AND CEODirectSell1112202569.1320,0001,382,60050,722,013Form
29Torley, HelenPRESIDENT AND CEODirectSell1112202568.7220,0001,374,33950,418,917Form
30Connaughton, Bernadette DirectSell1112202568.482,000136,9602,941,353Form
31Torley, HelenPRESIDENT AND CEODirectSell1003202569.0320,0001,380,63850,650,022Form
32Torley, HelenPRESIDENT AND CEODirectSell1003202571.2020,0001,424,08352,243,827Form
33Torley, HelenPRESIDENT AND CEODirectSell1003202575.3520,0001,507,02455,286,617Form
34Connaughton, BernadetteDirectSell1001202575.242,000150,4813,382,211Form
35Labrosse, NicoleSVP, CHIEF FINANCIAL OFFICERDirectSell923202577.952,227173,5841,720,957Form
36Labrosse, NicoleSVP, CHIEF FINANCIAL OFFICERDirectSell911202575.7120,0001,514,2671,840,289Form
37Torley, HelenPRESIDENT AND CEODirectSell904202574.0420,0001,480,77254,323,535Form
38Torley, HelenPRESIDENT AND CEODirectSell904202574.4420,0001,488,72654,615,328Form
39Torley, HelenPRESIDENT AND CEODirectSell904202573.7620,0001,475,12854,116,475Form
40Connaughton, BernadetteDirectSell902202573.684,000294,7363,459,614Form
41Torley, HelenPRESIDENT AND CEODirectSell813202564.3220,0001,286,35147,190,991Form
42Torley, HelenPRESIDENT AND CEODirectSell813202563.5120,0001,270,12146,595,600Form
43Torley, HelenPRESIDENT AND CEODirectSell813202563.0520,0001,260,91746,257,937Form
44Torley, HelenPRESIDENT AND CEODirectSell710202557.4320,0001,148,61842,138,133Form
45Torley, HelenPRESIDENT AND CEODirectSell710202556.4320,0001,128,65541,405,788Form
46Torley, HelenPRESIDENT AND CEODirectSell710202555.5120,0001,110,24540,730,375Form

Investor Activity (13F)

Updated Jul 26, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
2Xideas AG$5.9 Mil2.3%47TRIM -12.5%13F
Silverback Asset Management LLC$11.6 Mil2.3%45ADD +13.4%13F
Steelhead Partners LLC$19.8 Mil1.4%24New13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Steelhead Partners LLC$19.8 Mil1.4%24New13F
Silverback Asset Management LLC$11.6 Mil2.3%45ADD +13.4%13F
Active ManagerValue% of PortfolioTotal PositionsQoQAs OfFiling
Angelo Gordon & Co., L.P.$10.8 Mil1.0%46ExitedDec 31, 202513F
2Xideas AG$5.9 Mil2.3%47TRIM -12.5%Mar 31, 202613F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Steelhead Partners LLC$19.8 Mil1.4%24New13F
Silverback Asset Management LLC$11.6 Mil2.3%45ADD +13.4%13F
2Xideas AG$5.9 Mil2.3%47TRIM -12.5%13F
Core Cache Last Updated: 7/25/2026