Ligand Pharmaceuticals (LGND)


Market Price (11/10/2026): $313.81 | Market Cap: $6.3 BilSector: Health Care | Industry: Biotechnology

Ligand Pharmaceuticals (LGND)


Market Price (11/10/2026): $313.81
Market Cap: $6.3 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

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Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 36%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 23%

Low stock price volatility
Vol 12M is 37%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Pharmaceutical Technology Platforms, Show more.

Trading close to highs
Dist 52W High is -2.7%, Dist 3Y High is -2.7%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.53, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%

Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 103x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 69x, P/EPrice/Earnings or Price/(Net Income) is 122x

Weak revenue growth
Rev Chg QQuarterly Revenue Change % is -32%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 22%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -4.6%

Key risks
LGND key risks include [1] its heavy dependence on royalty assets, Show more.

0 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 36%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 23%
1 Low stock price volatility
Vol 12M is 37%
2 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Pharmaceutical Technology Platforms, Show more.
3 Trading close to highs
Dist 52W High is -2.7%, Dist 3Y High is -2.7%
4 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.53, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
5 Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 103x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 69x, P/EPrice/Earnings or Price/(Net Income) is 122x
6 Weak revenue growth
Rev Chg QQuarterly Revenue Change % is -32%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 22%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -4.6%
9 Key risks
LGND key risks include [1] its heavy dependence on royalty assets, Show more.

LGND in ETFs

Weight = LGND's share of each fund

VTI0.01%
ITOT0.01%
IWM0.21%
IJR0.37%
VB0.07%
IJT0.78%
SLYG0.76%
IWO0.44%
+11 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 11/2/2026

Ligand Pharmaceuticals (LGND) stock has gained about 10% since 7/31/2026 because of the following key factors:

1. Strong Q3 2026 Financial Performance Exceeding Analyst Expectations and Uplifted Full-Year Guidance. Ligand Pharmaceuticals reported adjusted diluted earnings per share (EPS) of $2.67 for fiscal Q3 2026 (ended September 30, 2026), surpassing the consensus estimate of approximately $2.33. Total revenue reached $78.7 million, exceeding the estimated $77.0 million. Following these results, the company raised its full-year 2026 adjusted diluted EPS guidance to a range of $9.50 to $9.75, up from the previous outlook of $9.00 to $9.50.

2. Significant Royalty Revenue Growth Driven by the XOMA Acquisition. Royalty revenue for fiscal Q3 2026 increased by 51% year-over-year to $70.3 million. This substantial growth was primarily attributed to the successful integration of the XOMA Royalty acquisition, which closed on July 14, 2026, for $739 million, significantly expanding Ligand's portfolio to over 200 royalty assets, including 7 new commercial products and 14 late-stage programs. Key commercial assets such as Filspari and Ohtuvayre also contributed to this momentum.

Show more
Updated on 11/2/2026

Ligand Pharmaceuticals (LGND) stock has gained about 10% since 7/31/2026 because of the following key factors:

1. Strong Q3 2026 Financial Performance Exceeding Analyst Expectations and Uplifted Full-Year Guidance. Ligand Pharmaceuticals reported adjusted diluted earnings per share (EPS) of $2.67 for fiscal Q3 2026 (ended September 30, 2026), surpassing the consensus estimate of approximately $2.33. Total revenue reached $78.7 million, exceeding the estimated $77.0 million. Following these results, the company raised its full-year 2026 adjusted diluted EPS guidance to a range of $9.50 to $9.75, up from the previous outlook of $9.00 to $9.50.

2. Significant Royalty Revenue Growth Driven by the XOMA Acquisition. Royalty revenue for fiscal Q3 2026 increased by 51% year-over-year to $70.3 million. This substantial growth was primarily attributed to the successful integration of the XOMA Royalty acquisition, which closed on July 14, 2026, for $739 million, significantly expanding Ligand's portfolio to over 200 royalty assets, including 7 new commercial products and 14 late-stage programs. Key commercial assets such as Filspari and Ohtuvayre also contributed to this momentum.

3. Positive Analyst Sentiment and Upgraded Price Targets. The company maintains a "Strong Buy" consensus rating from analysts. Following the Q3 earnings, multiple analysts adjusted their price targets upwards, with the average 12-month price target ranging from approximately $339.22 to $365.57, indicating a significant upside potential from the stock's recent trading levels. For instance, Bank of America Securities raised its price target to $406.

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Stock Movement Drivers

Fundamental Drivers

The 9.3% change in LGND stock from 7/31/2026 to 11/9/2026 was primarily driven by a 227.3% change in the company's P/E Multiple.
(LTM values as of)731202611092026Change
Stock Price ($)287.54314.159.3%
Change Contribution By: 
Total Revenues ($ Mil)274254-7.5%
Net Income Margin (%)55.9%20.3%-63.8%
P/E Multiple37.2121.9227.3%
Shares Outstanding (Mil)2020-0.4%
Cumulative Contribution9.3%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2026 to 11/9/2026
ReturnCorrelation
LGND9.3% 
Market (SPY)0.8%48.0%
Sector (XLV)15.9%23.7%

Fundamental Drivers

The 36.9% change in LGND stock from 4/30/2026 to 11/9/2026 was primarily driven by a 243.3% change in the company's P/E Multiple.
(LTM values as of)430202611092026Change
Stock Price ($)229.45314.1536.9%
Change Contribution By: 
Total Revenues ($ Mil)268254-5.3%
Net Income Margin (%)46.4%20.3%-56.3%
P/E Multiple35.5121.9243.3%
Shares Outstanding (Mil)1920-3.6%
Cumulative Contribution36.9%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 11/9/2026
ReturnCorrelation
LGND36.9% 
Market (SPY)5.0%30.9%
Sector (XLV)29.6%20.3%

Fundamental Drivers

The 64.2% change in LGND stock from 10/31/2025 to 11/9/2026 was primarily driven by a 35.3% change in the company's Total Revenues ($ Mil).
(LTM values as of)1031202511092026Change
Stock Price ($)191.31314.1564.2%
Change Contribution By: 
Total Revenues ($ Mil)18825435.3%
P/S Multiple19.724.725.3%
Shares Outstanding (Mil)1920-3.2%
Cumulative Contribution64.2%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 11/9/2026
ReturnCorrelation
LGND64.2% 
Market (SPY)11.3%31.1%
Sector (XLV)32.2%24.9%

Fundamental Drivers

The 500.8% change in LGND stock from 10/31/2023 to 11/9/2026 was primarily driven by a 266.3% change in the company's P/E Multiple.
(LTM values as of)1031202311092026Change
Stock Price ($)52.29314.15500.8%
Change Contribution By: 
Total Revenues ($ Mil)18025441.1%
Net Income Margin (%)15.1%20.3%34.3%
P/E Multiple33.3121.9266.3%
Shares Outstanding (Mil)1720-13.5%
Cumulative Contribution500.8%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2023 to 11/9/2026
ReturnCorrelation
LGND500.8% 
Market (SPY)86.2%38.5%
Sector (XLV)58.4%27.4%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
LGND Return55%-57%7%50%76%66%216%
Peers Return39%-23%21%8%15%-5%53%
S&P 500 Return27%-19%24%23%16%8%96%

Monthly Win Rates [3]
LGND Win Rate58%42%58%50%75%73% 
Peers Win Rate58%33%50%50%58%55% 
S&P 500 Win Rate75%42%67%75%67%36% 

Max Drawdowns [4]
LGND Max Drawdown-53%-60%-38%-23%-21%-15% 
Peers Max Drawdown-14%-43%-21%-15%-24%-22% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: INVA. See LGND Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 11/9/2026 (YTD)

How Low Can It Go

EventLGNDS&P 500
2025 US Tariff Shock
  % Loss-20.8%-18.8%
  % Gain to Breakeven26.2%23.1%
  Time to Breakeven92 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-26.3%-9.5%
  % Gain to Breakeven35.8%10.5%
  Time to Breakeven48 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-50.8%-24.5%
  % Gain to Breakeven103.4%32.4%
  Time to Breakeven1156 days427 days
2020 COVID-19 Crash
  % Loss-37.5%-33.7%
  % Gain to Breakeven60.0%50.9%
  Time to Breakeven51 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-50.5%-19.2%
  % Gain to Breakeven101.9%23.8%
  Time to Breakeven2732 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-11.0%-3.7%
  % Gain to Breakeven12.4%3.9%
  Time to Breakeven6 days6 days

Compare to INVA

In The Past

Ligand Pharmaceuticals's stock fell -20.8% during the 2025 US Tariff Shock. Such a loss loss requires a 26.2% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventLGNDS&P 500
2025 US Tariff Shock
  % Loss-20.8%-18.8%
  % Gain to Breakeven26.2%23.1%
  Time to Breakeven92 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-26.3%-9.5%
  % Gain to Breakeven35.8%10.5%
  Time to Breakeven48 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-50.8%-24.5%
  % Gain to Breakeven103.4%32.4%
  Time to Breakeven1156 days427 days
2020 COVID-19 Crash
  % Loss-37.5%-33.7%
  % Gain to Breakeven60.0%50.9%
  Time to Breakeven51 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-50.5%-19.2%
  % Gain to Breakeven101.9%23.8%
  Time to Breakeven2732 days105 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-26.3%-15.4%
  % Gain to Breakeven35.7%18.2%
  Time to Breakeven244 days125 days
2008-2009 Global Financial Crisis
  % Loss-76.3%-53.4%
  % Gain to Breakeven322.0%114.4%
  Time to Breakeven1657 days1085 days
Summer 2007 Credit Crunch
  % Loss-27.5%-8.6%
  % Gain to Breakeven38.0%9.5%
  Time to Breakeven2166 days47 days

Compare to INVA

In The Past

Ligand Pharmaceuticals's stock fell -20.8% during the 2025 US Tariff Shock. Such a loss loss requires a 26.2% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Ligand Pharmaceuticals (LGND)

Ligand Pharmaceuticals Incorporated is a biopharmaceutical company that specializes in developing and acquiring innovative technologies designed to assist other pharmaceutical companies in the discovery and development of new medicines globally. A core aspect of its business is its proprietary Captisol technology, a formulation enhancer that helps improve the solubility, stability, and bioavailability of drugs, which it also sells as a material to other manufacturers.

The company maintains a broad portfolio of commercialized medicines, many of which leverage its foundational technologies or have been acquired. Key products include Kyprolis and Evomela for multiple myeloma, Veklury for COVID-19, Rylaze for acute lymphoblastic leukemia, and specific Captisol-enabled formulations like Zulresso for postpartum depression and Nexterone for cardiovascular issues. Ligand's diverse offerings also extend to vaccines for pneumococcal disease, treatments for osteoporosis, and various autoimmune conditions.

Beyond its direct commercialized products, Ligand partners with and licenses its technologies to numerous pharmaceutical companies, whose programs are in clinical development across a wide spectrum of therapeutic areas, including cancer, diabetes, neurological disorders, and cardiovascular and kidney diseases. Therefore, its primary customers include other pharmaceutical companies utilizing its technologies and materials, with the ultimate beneficiaries being patients worldwide who receive the medicines developed and marketed through Ligand's contributions.

AI Analysis | Feedback

Here are 1-2 brief analogies to describe Ligand Pharmaceuticals (LGND):

  • Qualcomm for pharmaceutical innovation: Ligand develops and licenses foundational technologies, such as its Captisol material, that help other pharmaceutical companies discover and develop a wide range of medicines, similar to how Qualcomm provides essential chip technology and IP for the mobile industry.
  • Unilever for drug assets: Ligand manages a diverse portfolio of commercialized pharmaceutical products and development programs across various therapeutic areas, much like how Unilever manages a vast array of consumer brands.

AI Analysis | Feedback

  • Kyprolis: A pharmaceutical used to treat multiple myeloma.
  • Evomela: A pharmaceutical used to treat multiple myeloma.
  • Veklury: A treatment for moderate or severe COVID-19.
  • Teriparatide injection product: A medication used for osteoporosis.
  • Vaxneuvance: A vaccine for the prevention of invasive disease caused by Streptococcus pneumoniae.
  • Pneumosil: A pneumococcal conjugate vaccine for preventing pneumococcal pneumonia in children.
  • Rylaze: A recombinant erwinia asparaginase for treating acute lymphoblastic leukemia or lymphoblastic lymphoma.
  • Nexterone: A Captisol-enabled formulation of amiodarone.
  • Zulresso: A Captisol-enabled formulation of brexanolone for treating postpartum depression.
  • Noxafil-IV: A Captisol-enabled formulation of posaconazole for intravenous use.
  • Duavee: A medication for the treatment of postmenopausal osteoporosis.
  • Aziyo portfolio: Includes commercial pericardial repair products and CanGaroo envelope extracellular matrix products.
  • Exemptia: A pharmaceutical for autoimmune diseases.
  • Vivitra: A pharmaceutical for breast cancer.
  • Bryxta: A pharmaceutical product indicated for various conditions.
  • Zybev: A pharmaceutical product indicated for various conditions.
  • Minnebro: A pharmaceutical for the treatment of hypertension.
  • Captisol materials: Proprietary materials sold to pharmaceutical companies for drug formulation.

AI Analysis | Feedback

Ligand Pharmaceuticals (LGND) primarily sells to other companies, specifically within the pharmaceutical and biotechnology sectors.

Based on the provided company description, Ligand's business model involves developing or acquiring technologies (such as its Captisol material) and licensing programs that help other pharmaceutical companies discover, develop, and commercialize medicines. It also sells Captisol materials directly to these companies for use in their drug formulations.

While the description lists numerous commercial programs and products that utilize Ligand's technologies or are part of its licensed portfolio (e.g., Kyprolis, Veklury, Vaxneuvance, Rylaze, Zulresso, Noxafil-IV), it does not explicitly name the specific pharmaceutical companies that are direct customers or licensees for these programs and products. Therefore, a definitive list of named customer companies with their symbols cannot be provided from the given background information.

AI Analysis | Feedback

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Todd Davis, Chief Executive Officer

Todd Davis was appointed Chief Executive Officer of Ligand Pharmaceuticals in December 2022 and has been a member of the company's Board of Directors since 2007. He brings over 30 years of operational and investment experience in the biopharmaceutical and life sciences sectors. Mr. Davis was a founder and Managing Partner of HealthCare Royalty Partners (now HCRx), a global healthcare investment firm that grew to approximately $4 billion in capital commitments during his tenure. He also founded RoyaltyRx Capital in 2018, a special opportunities investment firm. His experience includes serving as a partner at Apax Partners, focusing on biopharmaceutical growth equity investments, and holding leadership roles in corporate development and general management at Elan Pharmaceuticals. He began his career in sales at Abbott Laboratories. Mr. Davis's extensive background with HealthCare Royalty Partners and Apax Partners demonstrates a pattern of managing companies backed by investment and private equity firms. He has also served on the boards of several biopharmaceutical companies.

Tavo Espinoza, Chief Financial Officer

Octavio "Tavo" Espinoza became Ligand Pharmaceuticals' Chief Financial Officer in November 2022, having joined the company in 2016. Before his appointment as CFO, he held positions as Senior Vice President of Finance from 2019 to 2022 and Senior Director of Accounting from 2016 to 2019 at Ligand. Prior to his time at Ligand, Mr. Espinoza served as Senior Director, Finance for Receptos, a publicly traded drug-discovery company that was subsequently acquired by Celgene (now Bristol-Myers Squibb), indicating his involvement with a company that was sold to an acquirer. He also held senior finance and accounting roles at Illumina and Intuit, and started his professional career in public accounting at PricewaterhouseCoopers. Mr. Espinoza is a Certified Public Accountant in California.

Andrew Reardon, Chief Legal Officer

Andrew Reardon has served as Ligand Pharmaceuticals' Chief Legal Officer since 2022. Before assuming this role, he was a Vice President and Special Counsel to the company. Mr. Reardon previously held the position of Chief Legal Officer at HealthCare Royalty Partners for over a decade, a global healthcare investment firm co-founded by Ligand's CEO, Todd Davis. His professional experience also includes working at the international law firm Willkie Farr & Gallagher, where he focused on corporate transactions, including finance and mergers and acquisitions. Additionally, he served as an executive with Citibank from 1997 to 2000.

AI Analysis | Feedback

The key risks to Ligand Pharmaceuticals (LGND) largely stem from its unique business model, which centers on technology licensing and royalty aggregation rather than direct drug development and commercialization.

  1. Reliance on Partner Success and Intellectual Property for Royalty and Milestone Revenue: Ligand's revenue is heavily dependent on the success of its collaboration partners in developing, gaining regulatory approval for, and commercially launching drugs that utilize Ligand's licensed technologies, such as Captisol, or for which Ligand owns royalty rights. Partners have significant discretion regarding the pursuit of development programs, and any failure to successfully develop a product, termination of agreements, or changes in partner strategy can directly reduce Ligand's milestone and royalty income. Discontinuation of partner programs can lead to financial asset impairment. Furthermore, the sustainability of Ligand's royalty-driven growth model faces risks from drug pricing pressures or the underperformance of key partnered drugs.

  2. Dependence on Captisol Technology and its Intellectual Property: Captisol is a proprietary, patent-protected technology critical to many of Ligand's commercial programs, enabling the solubility and stability of various drugs. The company maintains a broad global patent portfolio for Captisol, with the latest expiration dates extending to 2033-2035, and other applications potentially to 2040-2041. However, the competitive advantage derived from Captisol could be eroded by patent expirations, the development of superior competing drug delivery technologies, or its obsolescence. Additionally, Ligand is dependent on a single-source supplier for Captisol, which poses a supply chain disruption risk.

  3. Intense Competition for Royalty Acquisition Opportunities and in Biopharmaceutical Technologies: Ligand operates in a fiercely competitive market for acquiring high-quality royalty assets, which is a core part of its growth strategy. It competes with various entities, including other product-marketing companies and financial institutions, some of which may possess advantages such as lower capital costs, greater size, or existing strategic relationships. Beyond royalty acquisition, the biopharmaceutical industry is characterized by rapid technological advancements and intense competition. Ligand faces the constant threat of new entrants or existing competitors introducing superior drug delivery systems or other enabling technologies that could diminish the value or demand for its platforms, such as Captisol.

AI Analysis | Feedback

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AI Analysis | Feedback

Ligand Pharmaceuticals (LGND) is involved in developing and acquiring technologies to help pharmaceutical companies discover and develop medicines. The addressable markets for its main products and services are as follows:

  • Multiple Myeloma (Kyprolis, Evomela): The global multiple myeloma market size was estimated at USD 31.00 billion in 2026 and is projected to reach USD 49.79 billion by 2034. The market size in the United States was approximately USD 14,300 million in 2023.
  • COVID-19 Therapeutics (Veklury): The global COVID-19 therapeutics market size was valued at USD 30.7 billion in 2021 and was projected to contract to more than USD 16.2 billion by the end of 2031. Another estimate places the global COVID-19 therapeutics market size at USD 32542.5 million in 2025, projected to reach USD 8701.97 million by 2033.
  • Osteoporosis (Teriparatide injection product, Duavee): The global osteoporosis drugs market size was valued at USD 16.6 billion in 2024 and is predicted to reach USD 25.4 billion by 2032. The global osteoporosis treatment market was valued at USD 10.75 billion in 2018 and is projected to reach USD 19.68 billion by 2032. Specifically for Teriparatide, the global market for Teriparatide Injection was valued at approximately USD 2 billion and is anticipated to reach over USD 4 billion by 2032.
  • Pneumococcal Vaccine (Vaxneuvance, Pneumosil): The global pneumococcal vaccine market size was estimated at USD 8,070.9 million in 2023 and is projected to reach USD 12,191.7 million by 2030. Another report valued the global pneumococcal vaccine market at USD 8.8 billion in 2024, expecting it to grow to USD 15.1 billion in 2034.
  • Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma (Rylaze): The global Acute Lymphoblastic Leukemia market size was USD 3720 million in 2025 and is expected to boost sales to USD 6585.32 million by 2033. The acute lymphoblastic leukemia market across the top 7 major markets (US, EU4, UK, and Japan) reached a value of USD 2,270.5 million in 2024 and is expected to reach USD 4,137.2 million by 2035.
  • Postpartum Depression (Zulresso): The global postpartum depression drugs market size was estimated at USD 838.4 million in 2023 and is anticipated to reach USD 1.59 billion by 2030. The global postpartum depression treatment market size was valued at USD 114.83 million in 2025 and is projected to grow to USD 1,379.85 million by 2034. The postpartum depression market size in the 7MM (United States, EU4, UK, and Japan) was estimated to be USD 260 million in 2023.
  • Breast Cancer (Vivitra): The global breast cancer drugs market size was estimated at USD 36.62 billion in 2024 and is projected to reach USD 69.72 billion by 2033. Another report valued the global breast cancer market at USD 38.41 billion in 2025, projected to reach USD 89.91 billion by 2034.
  • Hypertension (Minnebro): The global anti-hypertensive drugs market size was valued at USD 23.9 billion in 2024 and is projected to grow to USD 35.5 billion by 2034. Another source estimates the global hypertension drugs market size at USD 27.8 billion in 2025, likely to cross USD 39.98 billion by 2035.
  • Captisol materials: null
  • Nexterone: null
  • Aziyo portfolio: null
  • Exemptia: null
  • Bryxta: null
  • Zybev: null

AI Analysis | Feedback

Ligand Pharmaceuticals (LGND) is poised for future revenue growth over the next 2-3 years, primarily driven by its robust royalty-generating portfolio, strategic investments in new assets, and the continued commercialization of key partnered products. Here are 3-5 expected drivers of future revenue growth: * **Growth from key commercial royalty products:** Ligand expects significant royalty revenue growth from several already launched products. These include Filspari, Ohtuvayre (Verona Pharma's ensifentrine, a treatment for COPD), Capvaxive (Merck's pneumococcal vaccine), Qarziba, Rylaze, Vaxneuvance, and Kyprolis. Management anticipates royalty revenues to witness a compound annual growth rate (CAGR) of at least 23% through 2030, with projections for 2026 royalty revenue reaching $200 million to $225 million. This growth is expected to be fueled by expanding markets and, in some cases, additional label or geographic opportunities. * **New product launches, notably Zelsuvmi:** The acquisition and subsequent launch of Zelsuvmi (berdazimer gel) for molluscum contagiosum infection is expected to be a significant contributor to royalty revenue growth. Zelsuvmi has already shown strong early sales performance. * **Strategic investments and disciplined capital deployment:** Ligand is actively pursuing new deals and deploying its substantial capital to acquire additional royalty interests, a core part of its business model. The company has stated it has approximately $1 billion in deployable capital, which is anticipated to enhance long-term royalty revenue growth through strategic investment allocation. * **Increased Captisol material sales:** While the company is shifting to a more royalty-focused model, sales of its proprietary Captisol materials are also projected to increase. This anticipated rise is partly driven by an expected inventory build for Gilead's Veklury, a Captisol-enabled formulation used for COVID-19 treatment.

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Share Repurchases

  • Ligand Pharmaceuticals announced a share repurchase program in August 2023, authorizing the company to buy back up to $50 million worth of its shares, with the program expiring in April 2026.
  • In Q3 2024, Ligand Pharmaceuticals spent $81.9 million on share buybacks.
  • As of September 2025, Ligand Pharmaceuticals's 3-Year Share Buyback Ratio was -4.40%, which can reflect no repurchases or potential share issuance over the period.

Share Issuance

  • In August 2025, Ligand Pharmaceuticals announced an offering of $400 million of convertible senior notes due in 2030.
  • Ligand Pharmaceuticals Incorporated filed a Follow-on Equity Offering in the amount of $100 million in February 2026.
  • Ligand Pharmaceuticals's shares outstanding increased by 0.4% in Q3 2025.

Outbound Investments

  • Ligand Pharmaceuticals deployed $192 million across eight investments in 2024.
  • Over the past two years (as of December 2025), Ligand committed over $400 million of investment capital across various strategies, including one "needle-moving immediate deal transaction" each year, such as Apeiron in 2024 and Pelthos in 2025.
  • Key acquisitions include Apeiron Biologics for $100 million in July 2024 and assets of Novan, Inc. for $12.2 million in September 2023, which included the NITRICIL™ technology platform and berdazimer gel.

Capital Expenditures

  • Ligand Pharmaceuticals reported capital expenditures of $15,000 in Q3 2024.
  • The company's capital expenditure (LTM) was $2.41 million as of June 2024.
  • Ligand Pharmaceuticals operates with an "infrastructure-light" model, contributing to low capital expenditures.

Better Bets vs. Ligand Pharmaceuticals (LGND)

Peer Outperformance in Biotechnology

LGND has outperformed 88% of its 364 Biotechnology peers over 5Y. Biotechnology ranks 9th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that LGND has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
81%
of 452 industry peers · 55.2% return
3Y
93%
of 398 industry peers · 467.3% return
5Y
88%
of 364 industry peers · 106.8% return
No Biotechnology peer with a comparable growth profile has beaten LGND by more than 20pp over 5Y.
Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is LGND's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 9.8%58.5%102.8% CAH 516% · MCK 395% · COR 192%
Health Care Services 20 34.0%25.5%10.9% HIMS 177% · RDNT 147% · DGX 101%
Managed Health Care 8 52.2%-4.3%-3.7% OSCR 98% · HQY 50% · ELV 5%
Health Care Facilities 26 23.0%20.7%-4.3% THC 263% · NHC 228% · EHC 190%
Health Care Equipment 50 11.7%22.1%-13.2% UFPT 383% · GKOS 358% · TMDX 202%
Pharmaceuticals 59 -11.8%20.4%-37.9% LQDA 1097% · XERS 709% · KNSA 590%
Health Care Supplies 11 29.2%20.4%-40.8% LNTH 235% · HAE 96% · MMSI 30%
Life Sciences Tools & Services 109 -0.8%-9.6%-74.3% AXGN 278% · MEDP 201% · NTRA 183%
Biotechnology ← 365 -21.2%-29.6%-80.6% ELVN 1218% · TRVI 1187% · DNTH 1113%
Health Care Technology 21 -19.4%-44.4%-82.6% VEEV -4% · DOCS -57%
Median of constituents with a full price history over each window. Top names are limited to companies above $2B market cap.

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

LGNDINVAMedian
NameLigand P.Innoviva  
Mkt Price313.8118.97166.39
Mkt Cap6.31.43.8
Rev LTM254438346
Op Inc LTM37170103
FCF LTM57183120
FCF 3Y Avg28181105
CFO LTM91183137
CFO 3Y Avg67183125

Growth & Margins

LGNDINVAMedian
NameLigand P.Innoviva  
Rev Chg LTM1.0%12.8%6.9%
Rev Chg 3Y Avg21.7%14.8%18.3%
Rev Chg Q-31.8%-1.6%-16.7%
QoQ Delta Rev Chg LTM-12.6%-0.4%-6.5%
Op Inc Chg LTM26.6%1.3%14.0%
Op Inc Chg 3Y Avg148.9%21.9%85.4%
Op Mgn LTM14.4%38.8%26.6%
Op Mgn 3Y Avg12.6%42.6%27.6%
QoQ Delta Op Mgn LTM-20.1%1.9%-9.1%
CFO/Rev LTM35.9%41.9%38.9%
CFO/Rev 3Y Avg32.9%46.6%39.8%
FCF/Rev LTM22.6%41.6%32.1%
FCF/Rev 3Y Avg11.8%46.2%29.0%

Valuation

LGNDINVAMedian
NameLigand P.Innoviva  
Mkt Cap6.31.43.8
P/S24.73.113.9
P/Op Inc171.68.089.8
P/EBIT102.85.654.2
P/E121.77.164.4
P/CFO68.87.538.1
Total Yield0.8%14.1%7.5%
Dividend Yield0.0%0.0%0.0%
FCF Yield 3Y Avg0.6%13.7%7.2%
D/E0.20.20.2
Net D/E0.1-0.2-0.1

Returns

LGNDINVAMedian
NameLigand P.Innoviva  
1M Rtn4.0%-10.6%-3.3%
3M Rtn6.1%-8.3%-1.1%
6M Rtn42.3%-15.8%13.3%
12M Rtn55.0%-9.1%23.0%
3Y Rtn466.6%40.8%253.7%
1M Excs Rtn9.5%-5.0%2.3%
3M Excs Rtn13.2%-4.0%4.6%
6M Excs Rtn42.8%-15.3%13.8%
12M Excs Rtn41.0%-17.6%11.7%
3Y Excs Rtn434.9%-27.9%203.5%

Comparison Analyses

null

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA203791  SITAVIGacyclovirtablet412201369.1%83.2%136.0%220.7%1,111.1%
Collapse to Preview
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA203791  SITAVIGacyclovirtablet412201369.1%83.2%136.0%220.7%1,111.1%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Development and licensing of biopharmaceutical assets268167131196 
Captisol    164
Contract revenue and other income    28
Royalties    49
Total268167131196242


Operating Income by Segment
$ Mil2014201320122011
CyDex221515
Ligand-20-1-6
Total20151-1


Net Income by Segment
$ Mil202520242023
Development and licensing of biopharmaceutical assets124-454
Total124-454


Assets by Segment
$ Mil2014201320122011
Ligand1843829111
CyDex7466769
Total258105104121


Price Behavior

Price Behavior
Market Price$314.15 
Market Cap ($ Bil)6.3 
First Trading Date11/18/1992 
Distance from 52W High-2.7% 
   50 Days200 Days
DMA Price$299.49$255.99
DMA Trendupup
Distance from DMA4.9%22.7%
 3M1YR
Volatility31.7%36.8%
Downside Capture73.5376.43
Upside Capture130.17113.61
Correlation (S&P 500)44.2%33.8%
LGND Betas & Captures as of 10/31/2026

 1M2M3M6M1Y3Y
Beta0.940.830.840.630.780.96
Up Beta1.881.471.051.361.390.85
Down Beta0.110.250.40-0.63-0.080.73
Up Capture166%147%118%131%126%305%
Bmk +ve Days12182862130427
Stock +ve Days13253570130417
Down Capture93%29%57%48%67%98%
Bmk -ve Days10253664121325
Stock -ve Days9182956121334

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with LGND
LGND51.1%36.8%1.18-
Sector ETF (XLV)30.8%17.0%1.4025.6%
Equity (SPY)13.3%13.7%0.6534.0%
Gold (GLD)3.7%28.8%0.1211.4%
Commodities (DBC)38.2%21.3%1.42-10.5%
Real Estate (VNQ)13.7%14.3%0.6517.3%
Bitcoin (BTCUSD)-25.3%43.6%-0.5510.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with LGND
LGND15.7%43.2%0.46-
Sector ETF (XLV)8.8%15.4%0.3734.8%
Equity (SPY)11.8%17.3%0.5144.3%
Gold (GLD)17.8%19.1%0.756.1%
Commodities (DBC)8.0%19.6%0.29-1.6%
Real Estate (VNQ)1.5%18.9%-0.0336.2%
Bitcoin (BTCUSD)4.4%51.6%0.2719.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with LGND
LGND12.7%45.2%0.43-
Sector ETF (XLV)12.6%16.8%0.6241.9%
Equity (SPY)15.3%18.0%0.7245.5%
Gold (GLD)12.1%16.5%0.605.6%
Commodities (DBC)7.6%18.1%0.339.7%
Real Estate (VNQ)6.1%20.7%0.2534.5%
Bitcoin (BTCUSD)60.0%66.3%1.0012.1%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date10152026
Short Interest: Shares Quantity2.5 Mil
Short Interest: % Change Since 9302026-6.6%
Average Daily Volume0.2 Mil
Days-to-Cover Short Interest10.5 days
Basic Shares Quantity20.0 Mil
Short % of Basic Shares12.5%

Earnings Returns History

Updated 11/9/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/29/2026-0.5%-0.8% 
8/6/2026-0.8%-3.1%-4.2%
5/7/2026-9.6%-4.9%1.9%
2/26/20262.5%9.2%6.4%
11/6/20259.4%8.0%-3.0%
8/7/20252.8%9.6%17.1%
5/8/2025-2.9%-0.5%0.4%
2/27/20250.6%0.3%-4.6%
...
SUMMARY STATS   
# Positive151610
# Negative9813
Median Positive4.6%7.2%5.5%
Median Negative-5.5%-6.6%-5.6%
Max Positive19.9%27.0%18.4%
Max Negative-9.6%-18.0%-22.0%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/29/2026-0.5%-0.8% 
8/6/2026-0.8%-3.1%-4.2%
5/7/2026-9.6%-4.9%1.9%
2/26/20262.5%9.2%6.4%
11/6/20259.4%8.0%-3.0%
8/7/20252.8%9.6%17.1%
5/8/2025-2.9%-0.5%0.4%
2/27/20250.6%0.3%-4.6%
11/7/202411.1%4.4%6.8%
8/6/2024-5.8%4.0%4.1%
5/7/20249.8%16.5%12.5%
2/27/202419.9%2.5%-7.8%
11/8/20234.6%8.1%18.4%
8/8/20235.3%0.7%-5.4%
5/4/20233.4%1.3%-7.4%
2/22/20234.1%2.5%-4.7%
11/7/202211.3%27.0%4.6%
8/8/20223.5%8.1%-5.6%
5/4/2022-5.5%-18.0%-11.5%
2/17/2022-8.6%-9.9%0.5%
11/9/20219.2%6.3%-5.7%
7/29/2021-4.6%-8.4%-3.9%
5/3/2021-9.1%-12.8%-22.0%
2/3/20210.2%21.9%-20.0%
SUMMARY STATS   
# Positive151610
# Negative9813
Median Positive4.6%7.2%5.5%
Median Negative-5.5%-6.6%-5.6%
Max Positive19.9%27.0%18.4%
Max Negative-9.6%-18.0%-22.0%

SEC Filings

Expand for More
Report DateFiling DateFiling
09/30/202610/30/202610-Q
06/30/202608/07/202610-Q
03/31/202605/08/202610-Q
12/31/202502/27/202610-K
09/30/202511/07/202510-Q
06/30/202508/08/202510-Q
03/31/202505/09/202510-Q
12/31/202402/28/202510-K
09/30/202411/08/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202302/29/202410-K
09/30/202311/09/202310-Q
06/30/202308/09/202310-Q
03/31/202305/08/202310-Q
12/31/202202/28/202310-K
Collapse to Preview
Report DateFiling DateFiling
09/30/202610/30/202610-Q
06/30/202608/07/202610-Q
03/31/202605/08/202610-Q
12/31/202502/27/202610-K
09/30/202511/07/202510-Q
06/30/202508/08/202510-Q
03/31/202505/09/202510-Q
12/31/202402/28/202510-K
09/30/202411/08/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202302/29/202410-K
09/30/202311/09/202310-Q
06/30/202308/09/202310-Q
03/31/202305/08/202310-Q
12/31/202202/28/202310-K
09/30/202211/08/202210-Q
06/30/202208/09/202210-Q
03/31/202205/09/202210-Q
12/31/202102/28/202210-K
09/30/202111/09/202110-Q
06/30/202108/03/202110-Q
03/31/202105/06/202110-Q
12/31/202002/24/202110-K
09/30/202011/06/202010-Q
06/30/202008/07/202010-Q
03/31/202005/08/202010-Q
12/31/201902/27/202010-K

Recent Forward Guidance

Updated 10/30/2026

Latest: Q3 2026 Earnings Reported 10/29/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Royalty RevenueReported225.00 Mil237.50 Mil250.00 Mil0.0% AffirmedGuidance: 237.50 Mil for 2026
2026 Captisol SalesReported35.00 Mil37.50 Mil40.00 Mil0.0% AffirmedGuidance: 37.50 Mil for 2026
2026 Contract RevenueReported10.00 Mil15.00 Mil20.00 Mil0.0% AffirmedGuidance: 15.00 Mil for 2026
2026 Total RevenueReported270.00 Mil290.00 Mil310.00 Mil0.0% AffirmedGuidance: 290.00 Mil for 2026
2026 Adjusted Diluted EPSReported9.59.639.754.1% RaisedGuidance: 9.25 for 2026


Prior: Q2 2026 Earnings Reported 8/6/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Royalty RevenueReported225.00 Mil237.50 Mil250.00 Mil0 AffirmedGuidance: 237.50 Mil for 2026
2026 Captisol RevenueReported35.00 Mil37.50 Mil40.00 Mil0 AffirmedGuidance: 37.50 Mil for 2026
2026 Contract RevenueReported10.00 Mil15.00 Mil20.00 Mil0 AffirmedGuidance: 15.00 Mil for 2026
2026 RevenueReported270.00 Mil290.00 Mil310.00 Mil0 AffirmedGuidance: 290.00 Mil for 2026
2026 Adjusted Net IncomeReported195.00 Mil200.50 Mil206.00 Mil   
2026 GAAP Net IncomeReported107.00 Mil112.50 Mil118.00 Mil   
2026 Adjusted EPSReported99.259.52.8% RaisedGuidance: 9 for 2026

Q1 2026 Earnings Reported 5/7/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Royalty RevenueReported225.00 Mil237.50 Mil250.00 Mil11.8% RaisedGuidance: 212.50 Mil for 2026
2026 Captisol RevenueReported35.00 Mil37.50 Mil40.00 Mil0 AffirmedGuidance: 37.50 Mil for 2026
2026 Contract RevenueReported10.00 Mil15.00 Mil20.00 Mil0 AffirmedGuidance: 15.00 Mil for 2026
2026 Total RevenueReported270.00 Mil290.00 Mil310.00 Mil9.4% RaisedGuidance: 265.00 Mil for 2026
2026 Adjusted EPSReported8.599.55.9% RaisedGuidance: 8.5 for 2026

Q4 2025 Earnings Reported 2/26/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Royalty RevenueReported200.00 Mil212.50 Mil225.00 Mil39.8% Higher NewGuidance: 152.00 Mil for 2025
2026 Captisol RevenueReported35.00 Mil37.50 Mil40.00 Mil-6.2% Lower NewGuidance: 40.00 Mil for 2025
2026 Contract RevenueReported10.00 Mil15.00 Mil20.00 Mil-60.5% Lower NewGuidance: 38.00 Mil for 2025
2026 Total RevenueReported245.00 Mil265.00 Mil285.00 Mil15.2% Higher NewGuidance: 230.00 Mil for 2025
2026 Adjusted EPSReported88.5913.0% Higher NewGuidance: 7.53 for 2025

Insider Activity

Updated 11/6/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Aryeh, Jason DirectSell11062026319.9928290,23734,711,235Form
2Reardon, AndrewCLO & SecretaryDirectSell11042026313.225,0001,566,0949,977,274Form
3Aryeh, Jason DirectSell11032026320.43700224,29834,848,902Form
4Aryeh, Jason DirectSell11032026320.241,411451,86035,052,926Form
5Reardon, AndrewCLO & SecretaryDirectSell10062026304.075,0001,520,3469,685,819Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Aryeh, Jason DirectSell11062026319.9928290,23734,711,235Form
2Reardon, AndrewCLO & SecretaryDirectSell11042026313.225,0001,566,0949,977,274Form
3Aryeh, Jason DirectSell11032026320.43700224,29834,848,902Form
4Aryeh, Jason DirectSell11032026320.241,411451,86035,052,926Form
5Reardon, AndrewCLO & SecretaryDirectSell10062026304.075,0001,520,3469,685,819Form
6Zimmermann, Martine DirectSell9142026285.001,200342,0001,110,645Form
7Reardon, AndrewCLO & SecretaryDirectSell9082026286.095,0001,430,43410,446,176Form
8Espinoza, OctavioChief Financial OfficerDirectSell8132026292.0631,6419,241,2298,089,032Form
9Haas, Jason DirectSell8132026292.817,1382,090,0621,165,668Form
10Reardon, AndrewCLO & SecretaryDirectSell8042026288.995,0001,444,95111,997,138Form
11Reardon, AndrewCLO & SecretaryDirectSell7062026313.285,0001,566,37713,005,315Form
12Sabba, Stephen LDirectSell6182026254.002,145544,8308,541,766Form
13Haas, Jason DirectSell6152026255.586,4611,651,3201,273,058Form
14Aryeh, Jason DirectSell6122026250.004,5001,125,00025,645,000Form
15Aryeh, Jason DirectSell6122026250.00500125,00026,770,000Form
16Lamattina, John L DirectSell6122026250.884,5911,151,7746,765,890Form
17Reardon, AndrewCLO & SecretaryDirectSell6022026227.065,0001,135,3169,396,326Form
18Kozarich, John W DirectSell5142026223.501,575352,0129,339,171Form
19Kozarich, John W DirectSell5142026224.00459102,8169,360,064Form
20Kozarich, John W DirectSell5142026231.80467108,2519,686,042Form
21Reardon, AndrewCLO & SecretaryDirectSell5042026231.315,0001,156,5569,572,117Form
22Kozarich, John W DirectSell4022026202.2346794,4408,544,705Form
23Reardon, AndrewCLO & SecretaryDirectSell4022026201.245,0001,006,2248,327,913Form
24Lamattina, John L DirectSell3312026200.762,161433,8426,168,150Form
25Sabba, Stephen LDirectSell3252026207.871,000207,8736,816,769Form
26Espinoza, OctavioChief Financial OfficerDirectSell3132026225.003,057687,8254,727,250Form
27Reardon, AndrewCLO & SecretaryDirectSell3062026206.355,0001,031,7707,608,068Form
28Espinoza, OctavioChief Financial OfficerDirectSell3062026205.8313,4232,762,8224,458,635Form
29Kozarich, John W DirectSell3042026200.5046793,6328,565,256Form
30Kozarich, John W DirectSell2042026195.9146791,4908,460,771Form
31Kozarich, John W DirectSell1062026189.5846788,5328,275,797Form
32Espinoza, OctavioChief Financial OfficerDirectSell12162025188.311,804339,7114,931,086Form
33Kozarich, John W DirectSell12032025195.8446791,4578,640,620Form
34Gray, Nancy Ryan DirectSell11122025205.456,5711,350,0121,662,912Form
35Lamattina, John L DirectSell11122025205.454,179858,5766,312,246Form
36Kozarich, John W DirectSell11052025191.0546789,2198,518,410Form
Core Cache Last Updated: 11/9/2026