Eupraxia Pharmaceuticals (EPRX)


Market Price (8/25/2026): $7.14 | Market Cap: $472.8 MilSector: Health Care | Industry: Biotechnology

Eupraxia Pharmaceuticals (EPRX)


Market Price (8/25/2026): $7.14
Market Cap: $472.8 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -27%

Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Chronic Pain Management, and Targeted Therapies.

Weak multi-year price returns
3Y Excs Rtn is -42%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.99

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -57 Mil

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -15%

Key risks
EPRX key risks include [1] its dependence on external financing as a pre-revenue company and [2] uncertain market adoption of its proprietary DiffuSphere™ delivery technology.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -27%
1 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Chronic Pain Management, and Targeted Therapies.
2 Weak multi-year price returns
3Y Excs Rtn is -42%
3 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.99
4 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -57 Mil
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -15%
7 Key risks
EPRX key risks include [1] its dependence on external financing as a pre-revenue company and [2] uncertain market adoption of its proprietary DiffuSphere™ delivery technology.

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 8/24/2026

Eupraxia Pharmaceuticals (EPRX) stock has lost about 5% since 4/30/2026 because of the following key factors:

1. Eupraxia Pharmaceuticals experienced significantly widened operating losses in fiscal Q2 2026, which ended June 30, 2026. The company reported a net loss of $14.5 million, a substantial increase from the $8.7 million net loss in fiscal Q2 2025. This increase was primarily driven by higher research and development (R&D) and general and administrative (G&A) expenses, mainly attributed to the expansion of its RESOLVE Part 2 trial in eosinophilic esophagitis (EoE). For the six months ended June 30, 2026, the net loss similarly broadened to $27.1 million, compared to $15.5 million in the prior year, with R&D spending rising to $24.0 million and G&A expenses to $10.1 million.

2. The company missed its fiscal Q1 2026 earnings per share (EPS) estimates. Eupraxia Pharmaceuticals reported an EPS of -$0.23 for fiscal Q1 2026, which was released on May 12, 2026, missing analysts' consensus estimates of -$0.22 per share by $0.01. This slight miss contributed to negative investor sentiment.

Show more
Updated on 8/24/2026

Eupraxia Pharmaceuticals (EPRX) stock has lost about 5% since 4/30/2026 because of the following key factors:

1. Eupraxia Pharmaceuticals experienced significantly widened operating losses in fiscal Q2 2026, which ended June 30, 2026. The company reported a net loss of $14.5 million, a substantial increase from the $8.7 million net loss in fiscal Q2 2025. This increase was primarily driven by higher research and development (R&D) and general and administrative (G&A) expenses, mainly attributed to the expansion of its RESOLVE Part 2 trial in eosinophilic esophagitis (EoE). For the six months ended June 30, 2026, the net loss similarly broadened to $27.1 million, compared to $15.5 million in the prior year, with R&D spending rising to $24.0 million and G&A expenses to $10.1 million.

2. The company missed its fiscal Q1 2026 earnings per share (EPS) estimates. Eupraxia Pharmaceuticals reported an EPS of -$0.23 for fiscal Q1 2026, which was released on May 12, 2026, missing analysts' consensus estimates of -$0.22 per share by $0.01. This slight miss contributed to negative investor sentiment.

3. Despite positive clinical data and strong liquidity, the inherent risks of a pre-revenue biotechnology company and ongoing capital burn likely weighed on the stock. While Eupraxia announced positive 36-week data from its RESOLVE trial in EoE on April 21, 2026, demonstrating improved inflammation and 66% symptom remission in the highest-dose cohort, and strengthened its liquidity with a $58.6 million net equity offering in February 2026, the company remains pre-revenue with an accumulated deficit of $196.7 million as of June 30, 2026. The expanded clinical trial, while a positive operational step, directly resulted in increased expenses, highlighting the continued capital intensity and dependence on future financing for a company without product revenue, thus limiting significant upward momentum.

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Stock Movement Drivers

Fundamental Drivers

The -6.7% change in EPRX stock from 4/30/2026 to 8/24/2026 was primarily driven by a -22.5% change in the company's Shares Outstanding (Mil).
(LTM values as of)43020268242026Change
Stock Price ($)7.807.28-6.7%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)5166-22.5%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 8/24/2026
ReturnCorrelation
EPRX-6.7% 
Market (SPY)6.2%31.3%
Sector (XLV)19.7%0.2%

Fundamental Drivers

The -12.1% change in EPRX stock from 1/31/2026 to 8/24/2026 was primarily driven by a -44.3% change in the company's Shares Outstanding (Mil).
(LTM values as of)13120268242026Change
Stock Price ($)8.287.28-12.1%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)3766-44.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 8/24/2026
ReturnCorrelation
EPRX-12.1% 
Market (SPY)10.6%35.7%
Sector (XLV)13.4%7.3%

Fundamental Drivers

The 34.8% change in EPRX stock from 7/31/2025 to 8/24/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)73120258242026Change
Stock Price ($)5.407.2834.8%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)3666-46.1%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2025 to 8/24/2026
ReturnCorrelation
EPRX34.8% 
Market (SPY)21.8%30.8%
Sector (XLV)35.7%6.0%

Fundamental Drivers

The 31.9% change in EPRX stock from 7/31/2023 to 8/24/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)73120238242026Change
Stock Price ($)5.527.2831.9%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)2266-67.2%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2023 to 8/24/2026
ReturnCorrelation
EPRX31.9% 
Market (SPY)72.7%16.7%
Sector (XLV)36.3%9.6%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
EPRX Return-18%17%55%-24%138%-11%141%
Peers Return-7%32%41%-1%13%5%101%
S&P 500 Return27%-19%24%23%16%12%104%

Monthly Win Rates [3]
EPRX Win Rate40%17%42%33%50%38% 
Peers Win Rate42%67%58%50%83%42% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
EPRX Max Drawdown--63%-42%-58%-32%-36% 
Peers Max Drawdown-27%-19%-12%-23%-29%-15% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: VRTX, APMD, ATTO, BLSM, BRVE.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 8/24/2026 (YTD)

How Low Can It Go

EventEPRXS&P 500
2025 US Tariff Shock
  % Loss-12.9%-18.8%
  % Gain to Breakeven14.9%23.1%
  Time to Breakeven17 days79 days
2024 Yen Carry Trade Unwind
  % Loss-14.3%-7.8%
  % Gain to Breakeven16.7%8.5%
  Time to Breakeven43 days18 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-32.6%-9.5%
  % Gain to Breakeven48.3%10.5%
  Time to Breakeven692 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-34.0%-24.5%
  % Gain to Breakeven51.5%32.4%
  Time to Breakeven126 days427 days

Compare to VRTX, APMD, ATTO, BLSM, BRVE

In The Past

Eupraxia Pharmaceuticals's stock fell -12.9% during the 2025 US Tariff Shock. Such a loss loss requires a 14.9% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventEPRXS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-32.6%-9.5%
  % Gain to Breakeven48.3%10.5%
  Time to Breakeven692 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-34.0%-24.5%
  % Gain to Breakeven51.5%32.4%
  Time to Breakeven126 days427 days

Compare to VRTX, APMD, ATTO, BLSM, BRVE

In The Past

Eupraxia Pharmaceuticals's stock fell -12.9% during the 2025 US Tariff Shock. Such a loss loss requires a 14.9% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Eupraxia Pharmaceuticals (EPRX)

Eupraxia Pharmaceuticals Inc. (EPRX) is a clinical-stage biotechnology company focused on the discovery, development, and marketing of innovative technologies in the biotechnology sector. Headquartered in Victoria, Canada, the company's business model centers on advancing a pipeline of novel product candidates through clinical trials to address significant unmet medical needs across various disease areas.

The company's main product candidates are EP-104IAR, which is currently in a Phase III clinical trial for the treatment and pain relief associated with knee osteoarthritis. Another key candidate, EP-104GI, is in a Phase II clinical trial targeting eosinophilic esophagitis. Eupraxia also has EP-104 in preclinical studies for other inflammatory joint conditions, benign structures of the esophagus, and epidural delivery. Additionally, the company is actively developing product candidates within the oncology space.

Eupraxia Pharmaceuticals aims to serve patients globally who suffer from chronic and debilitating conditions. Its primary customer base includes individuals seeking relief from knee osteoarthritis pain, as well as those affected by eosinophilic esophagitis and various other inflammatory joint conditions. With its expansion into oncology, the company is also targeting the market for cancer treatments, positioning itself within the pharmaceutical sector focused on pain management, gastrointestinal disorders, inflammatory diseases, and cancer.

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1. Think of it as an early-stage Amgen or Vertex Pharmaceuticals, intensely focused on developing new drugs for conditions like pain relief and inflammatory diseases, with its candidates currently in clinical trials.

2. It's an aspiring Regeneron Pharmaceuticals, with a pipeline of innovative drug candidates for conditions such as knee osteoarthritis and eosinophilic esophagitis, currently undergoing clinical trials.

3. A focused drug development company aiming for breakthroughs in specific disease areas like pain and inflammation, much like Vertex Pharmaceuticals became known for its work in cystic fibrosis, but currently with products in clinical trials.

AI Analysis | Feedback

  • EP-104IAR: A product candidate in Phase III clinical trial for pain relief in knee osteoarthritis and other unmet medical needs.
  • EP-104GI: A product candidate in Phase II clinical trial for the treatment of eosinophilic esophagitis.
  • EP-104: A product candidate under preclinical studies for inflammatory joint conditions, benign structures of the esophagus, and epidural delivery.
  • Oncology product candidates: Various product candidates currently under development for oncology.

AI Analysis | Feedback

Eupraxia Pharmaceuticals Inc. (EPRX) is a clinical-stage biotechnology company focused on the discovery, development, and marketing of drug candidates. As such, its lead product candidates are currently in various phases of clinical trials (Phase III, Phase II, and preclinical studies) and have not yet received regulatory approval for commercialization.

Therefore, Eupraxia Pharmaceuticals Inc. does not currently have major commercial customers, as its products are still under development and are not yet available for sale to other companies or individuals.

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Dr. James A. Helliwell, M.D., Chief Executive Officer and Director

Dr. James A. Helliwell co-founded Eupraxia Pharmaceuticals Inc. in 2012. Before co-founding Eupraxia, he was a cardiothoracic anesthesiologist. He is also an angel investor in two startups.

Alexander Rothwell, Chief Financial Officer

Alexander Rothwell was re-appointed as Chief Financial Officer of Eupraxia Pharmaceuticals in February 2025, having previously served in the role from 2018-2021. He possesses over 25 years of experience in Canadian capital markets and investment banking, beginning his career in 1995 in institutional equities and merger arbitrage. His past leadership roles include President and Executive Director of Macquarie Capital Markets Canada. Most recently, he was a Senior Advisor to Fort Capital Partners, a Canadian boutique investment bank.

Dr. Amanda Malone, Chief Scientific Officer and Chief Operating Officer

Dr. Amanda Malone co-founded Eupraxia Pharmaceuticals Inc. with Dr. Helliwell in 2012. She was instrumental in establishing the company's research, manufacturing, quality, non-clinical, regulatory, intellectual property, and clinical functions. Dr. Malone holds a PhD in biomedical engineering and is an inventor on six patent families that have led to over 70 patents and patent applications.

Paul Brennan, Chief Business Officer

Paul Brennan serves as the Chief Business Officer for Eupraxia Pharmaceuticals Inc.

Dr. Mark Kowalski, M.D., Pd.D., Chief Medical Officer

Dr. Mark Kowalski is the Chief Medical Officer at Eupraxia Pharmaceuticals Inc.

AI Analysis | Feedback

Eupraxia Pharmaceuticals Inc., as a clinical-stage biotechnology company, faces several inherent and significant risks primarily associated with the development and commercialization of its product candidates. The three most significant key risks to its business are:

Clinical Trial Failure

The most critical risk for Eupraxia Pharmaceuticals is the potential for its clinical trials to fail. The company's lead product candidates, EP-104IAR and EP-104GI, are currently in Phase III and Phase II clinical trials, respectively. There is a risk that these trials may "fail to demonstrate adequately the safety and efficacy of its product candidates at any stage of clinical development". Furthermore, trials could be "required to suspend or discontinue [...] due to side effects or other safety risks". The success of these trials is paramount to the company's future and its ability to bring any product to market.

Regulatory Approval Risk

Following successful clinical trials, Eupraxia Pharmaceuticals faces the substantial risk of not obtaining regulatory approval for its product candidates. Even with positive trial data, "future technology will require regulatory approval, which is costly and the Company may not be able to obtain it". The company may "fail to obtain regulatory approvals or only obtain approvals for limited uses or indications," which could significantly restrict market potential and profitability.

Need for Additional Financing and Capital Requirements

As a clinical-stage biotechnology company without revenue-generating products, Eupraxia Pharmaceuticals has a "limited operating history" and relies heavily on external funding to finance its extensive and costly research and development activities and clinical trials. There is a continuous "risk that additional financing [...] may not be available" when needed. Past reports have indicated concerns about its "cash burn" and cash runway, highlighting the ongoing challenge of securing sufficient capital to sustain operations and advance its pipeline.

AI Analysis | Feedback

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EP-104IAR (pain relief for knee osteoarthritis)

  • Global market size: USD 6.7 billion in 2024, projected to reach USD 14.3 billion by 2034.
  • U.S. market size: USD 2.6 billion in 2024.

EP-104GI (eosinophilic esophagitis)

  • Global market size: USD 366.2 million in 2024, projected to reach USD 5.6 billion by 2034.
  • U.S. market size: USD 151.3 million in 2024.

EP-104 (other inflammatory joint conditions)

  • Global arthritis market size: Approximately USD 59.0 billion in 2024 (derived from the global anti-inflammatory market where arthritis held a 48.2% share).
  • U.S. arthritis market size: USD 41.77 billion in 2024.

EP-104 (benign strictures of the esophagus)

  • null

EP-104 (epidural delivery)

  • Global epidural and spinal anesthesia drug market size: USD 1.25 billion in 2025, projected to grow to USD 1.76 billion by 2034.
  • U.S. epidural and spinal anesthesia drug market size: Approximately USD 1.0 billion in 2025 (representing over 80% of the global market).

AI Analysis | Feedback

Eupraxia Pharmaceuticals Inc. (EPRX), a clinical-stage biotechnology company, is poised for potential future revenue growth primarily through the advancement and commercialization of its proprietary drug candidates and the expansion of its innovative Diffusphere™ technology into new therapeutic areas. As the company is currently in the clinical stage, all projected revenue growth over the next 2-3 years will stem from the successful progression and eventual market entry of its pipeline. Here are the key expected drivers of future revenue growth: * **Commercialization of EP-104IAR for Knee Osteoarthritis:** Eupraxia's lead product candidate, EP-104IAR, is currently in a Phase III clinical trial for the treatment of pain associated with knee osteoarthritis (OA). The company has reported positive results from its Phase 2b clinical trial, which met its primary endpoint and three of four secondary endpoints. Eupraxia anticipates dosing the first patient in its Phase III program during the third quarter of 2024. Successful completion of this pivotal trial and subsequent regulatory approvals in key markets such as Europe and Brazil, where intellectual property protection extends until 2034, will be a primary driver of initial revenue. * **Commercialization and Expanded Indications for EP-104GI in Eosinophilic Esophagitis (EoE):** The company's other significant product candidate, EP-104GI, is progressing through Phase II clinical trials for eosinophilic esophagitis (EoE). Eupraxia has announced positive data from its ongoing RESOLVE trial, including consistent 52-week follow-up data and positive tissue health data demonstrating near-complete improvement on biopsy. Top-line data from the Phase 2b part of the RESOLVE trial is expected in the third quarter of 2026. Furthermore, Eupraxia plans to accelerate and expand clinical studies for EP-104GI into additional gastrointestinal indications, such as esophageal strictures and fibrostenotic Crohn's disease, broadening its potential market reach. * **Pipeline Expansion Leveraging Diffusphere™ Technology:** Eupraxia's proprietary Diffusphere™ technology is a versatile drug delivery platform designed for targeted, extended-release formulations. Beyond its lead candidates, the company is actively developing a pipeline of earlier-stage long-acting formulations. These include potential candidates for other inflammatory joint conditions and oncology, offering multiple avenues for future product development and subsequent revenue generation. Proceeds from recent public offerings are intended to support research and development of these additional pipeline candidates, accelerating their progression.

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Share Issuance

  • Eupraxia Pharmaceuticals closed a public offering in February 2026, issuing 7,607,145 common shares at US$7.00 per share and 1,428,571 pre-funded warrants at US$6.99999 per pre-funded warrant, raising approximately US$63.2 million in gross proceeds.
  • In September 2025, the company completed a public offering of 14,636,363 common shares at US$5.50 per share, generating approximately US$80.5 million in gross proceeds.
  • A non-brokered private placement was completed in October 2024, involving the issuance of 8,905,638 Series 1 Preferred shares at C$5.00 per share, resulting in aggregate gross proceeds of C$44,528,190.

Inbound Investments

  • Eupraxia Pharmaceuticals completed a non-brokered private placement in October 2024, raising C$44.5 million from Series 1 Preferred shares. In connection with this private placement, Mr. Joseph Freedman, a private equity investor, was appointed to the company's board of directors.

Capital Expenditures

  • For the last 12 months, capital expenditures were approximately -$588,947.
  • In the fiscal year 2023, capital expenditures amounted to $99.03K.
  • The company indicates that proceeds from recent offerings may be used, in part, for capital expenditures, alongside general corporate and administrative expenses, to support future growth and intellectual property expansion.

Peer Outperformance in Biotechnology

EPRX has outperformed 90% of its 364 Biotechnology peers over 5Y. Biotechnology ranks 10th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that EPRX has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
62%
of 460 industry peers · 37.9% return
3Y
66%
of 406 industry peers · 31.9% return
5Y
90%
of 364 industry peers · 161.0% return
No Biotechnology peer with a comparable growth profile has beaten EPRX by more than 20pp over 5Y.
Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is EPRX's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 7 11.5%85.0%132.2% CAH 400% · MCK 348% · COR 189%
Health Care Services 20 20.9%46.0%3.9% HIMS 314% · RDNT 146% · DGX 80%
Managed Health Care 8 32.1%-1.6%3.5% OSCR 143% · HQY 64% · ELV 16%
Health Care Facilities 24 7.9%-2.8%-17.5% THC 278% · NHC 257% · ENSG 125%
Health Care Equipment 50 -2.9%-6.1%-21.0% POCI 10987% · UFPT 367% · GKOS 253%
Health Care Supplies 12 34.1%-12.7%-32.6% LNTH 301% · HAE 81% · MMSI 30%
Pharmaceuticals 63 4.3%6.4%-37.4% LQDA 2532% · INDV 1260% · ETON 1176%
Life Sciences Tools & Services 108 -3.6%-28.4%-72.7% SNWV 1827% · ELMD 249% · MEDP 243%
Health Care Technology 21 -21.8%-55.6%-74.4% SPOK 125% · HSTM -1% · VEEV -24%
Biotechnology ← 365 7.1%-26.0%-78.7% BRTX 106500% · CELZ 1629% · DNTH 1519%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

EPRXVRTXAPMDATTOBLSMBRVEMedian
NameEupraxia.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Mkt Price7.28547.5925.6320.6216.0327.5023.12
Mkt Cap0.5138.9----69.7
Rev LTM012,587----6,294
Op Inc LTM-574,777----2,360
FCF LTM-383,796----1,879
FCF 3Y Avg-321,957----963
CFO LTM-374,293----2,128
CFO 3Y Avg-312,398----1,184

Growth & Margins

EPRXVRTXAPMDATTOBLSMBRVEMedian
NameEupraxia.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Rev Chg LTM-10.2%----10.2%
Rev Chg 3Y Avg-9.8%----9.8%
Rev Chg Q-12.5%----12.5%
QoQ Delta Rev Chg LTM-3.0%----3.0%
Op Inc Chg LTM-95.9%2,497.9%----1,201.0%
Op Inc Chg 3Y Avg-49.0%792.2%----371.6%
Op Mgn LTM-37.9%----37.9%
Op Mgn 3Y Avg-23.9%----23.9%
QoQ Delta Op Mgn LTM--0.2%-----0.2%
CFO/Rev LTM-34.1%----34.1%
CFO/Rev 3Y Avg-19.6%----19.6%
FCF/Rev LTM-30.2%----30.2%
FCF/Rev 3Y Avg-15.7%----15.7%

Valuation

EPRXVRTXAPMDATTOBLSMBRVEMedian
NameEupraxia.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Mkt Cap0.5138.9----69.7
P/S-11.0----11.0
P/Op Inc-8.429.1----10.3
P/EBIT-8.427.5----9.6
P/E-9.631.5----11.0
P/CFO-12.932.4----9.7
Total Yield-10.4%3.2%-----3.6%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-17.3%1.6%-----7.8%
D/E0.00.0----0.0
Net D/E-0.3-0.0-----0.2

Returns

EPRXVRTXAPMDATTOBLSMBRVEMedian
NameEupraxia.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
1M Rtn25.3%14.7%2.5%-5.8%0.2%-7.7%1.4%
3M Rtn2.5%26.0%2.5%-5.8%0.2%-7.7%1.4%
6M Rtn-10.8%13.8%2.5%-5.8%0.2%-7.7%-2.8%
12M Rtn37.9%38.6%2.5%-5.8%0.2%-7.7%1.4%
3Y Rtn31.9%56.4%2.5%-5.8%0.2%-7.7%1.4%
1M Excs Rtn22.1%11.5%-0.7%-9.1%-3.1%-11.0%-1.9%
3M Excs Rtn0.1%23.6%0.1%-8.2%-2.2%-10.1%-1.0%
6M Excs Rtn-22.7%1.9%-9.4%-17.8%-11.7%-19.6%-14.7%
12M Excs Rtn19.7%17.6%-17.6%-26.0%-19.9%-27.9%-18.8%
3Y Excs Rtn-41.5%-15.9%-72.6%-81.0%-74.9%-82.8%-73.8%

Comparison Analyses

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Financials

Segment Financials

Net Income by Segment
$ Mil202520242023
Creating product candidates designed optimize drug delivery for applications with significant unmet-39-26-29
Total-39-26-29


Assets by Segment
$ Mil20232022202120202019
Single Segment15142413
Total15142413


Price Behavior

Price Behavior
Market Price$7.28 
Market Cap ($ Bil)0.4 
First Trading Date08/03/2021 
Distance from 52W High-19.7% 
   50 Days200 Days
DMA Price$6.47$7.07
DMA Trendupdown
Distance from DMA12.5%3.0%
 3M1YR
Volatility55.7%62.2%
Downside Capture77.97155.19
Upside Capture80.93161.22
Correlation (SPY)33.9%31.4%
EPRX Betas & Captures as of 7/31/2026

 1M2M3M6M1Y3Y
Beta1.261.341.541.501.500.66
Up Beta5.002.592.011.981.490.35
Down Beta0.331.661.111.351.260.57
Up Capture19%52%93%98%208%61%
Bmk +ve Days11223567138427
Stock +ve Days9202856120285
Down Capture70%112%196%157%137%99%
Bmk -ve Days11212859114326
Stock -ve Days13233569128311

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with EPRX
EPRX40.1%61.9%0.78-
Sector ETF (XLV)29.3%16.0%1.416.0%
Equity (SPY)21.2%12.9%1.2330.7%
Gold (GLD)39.0%28.8%1.1432.4%
Commodities (DBC)40.9%20.2%1.584.3%
Real Estate (VNQ)13.9%13.8%0.7011.2%
Bitcoin (BTCUSD)-30.4%44.2%-0.6913.9%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with EPRX
EPRX3.8%70.4%0.40-
Sector ETF (XLV)6.9%15.1%0.2710.6%
Equity (SPY)12.8%17.2%0.5715.7%
Gold (GLD)20.6%18.6%0.9013.5%
Commodities (DBC)10.2%19.6%0.412.2%
Real Estate (VNQ)2.4%18.9%0.0215.5%
Bitcoin (BTCUSD)11.2%52.8%0.408.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with EPRX
EPRX1.9%70.4%0.40-
Sector ETF (XLV)10.7%16.7%0.5210.6%
Equity (SPY)15.1%17.9%0.7215.7%
Gold (GLD)12.9%16.3%0.6513.5%
Commodities (DBC)7.8%18.1%0.352.2%
Real Estate (VNQ)5.0%20.7%0.2015.5%
Bitcoin (BTCUSD)63.1%66.2%1.038.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date7312026
Short Interest: Shares Quantity6.0 Mil
Short Interest: % Change Since 71520262.1%
Average Daily Volume0.5 Mil
Days-to-Cover Short Interest13.0 days
Basic Shares Quantity66.2 Mil
Short % of Basic Shares9.1%

Earnings Returns History

Updated 6/3/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
SUMMARY STATS   
# Positive000
# Negative000
Median Positive   
Median Negative   
Max Positive   
Max Negative   
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
SUMMARY STATS   
# Positive000
# Negative000
Median Positive   
Median Negative   
Max Positive   
Max Negative   

SEC Filings

Expand for More
Report DateFiling DateFiling
03/31/202605/12/20266-K
12/31/202503/13/202640-F
09/30/202511/04/20256-K
06/30/202508/13/20256-K
03/31/202505/06/20256-K
12/31/202403/20/202540-F
09/30/202411/07/20246-K
06/30/202408/07/20246-K
03/31/202405/08/20246-K
12/31/202304/01/202440-F
Collapse to Preview
Report DateFiling DateFiling
03/31/202605/12/20266-K
12/31/202503/13/202640-F
09/30/202511/04/20256-K
06/30/202508/13/20256-K
03/31/202505/06/20256-K
12/31/202403/20/202540-F
09/30/202411/07/20246-K
06/30/202408/07/20246-K
03/31/202405/08/20246-K
12/31/202304/01/202440-F

Investor Activity (13F)

Updated Aug 25, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Great Point Partners LLC$8.7 Mil2.1%39Hold13F
Vivo Capital, LLC$9.8 Mil0.8%46Hold13F
Redmile Group, LLC$5.1 Mil0.3%35New13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Redmile Group, LLC$5.1 Mil0.3%35New13F
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Vivo Capital, LLC$9.8 Mil0.8%46Hold13F
Great Point Partners LLC$8.7 Mil2.1%39Hold13F
Redmile Group, LLC$5.1 Mil0.3%35New13F
Core Cache Last Updated: 8/24/2026