Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -33%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 100%

Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Biopharmaceutical R&D, and Targeted Therapies.

Weak multi-year price returns
2Y Excs Rtn is -39%, 3Y Excs Rtn is -72%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.37, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 19%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -211 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2114%

Expensive valuation multiples
P/SPrice/Sales ratio is 102x

Stock price has recently run up significantly
12M Rtn12 month market price return is 121%

Weak revenue growth
Rev Chg QQuarterly Revenue Change % is null

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 263%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1723%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -2074%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 64%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -41%

High stock price volatility
Vol 12M is 115%

Key risks
[ZBIO] key risks include [1] an extreme dependence on a limited product pipeline, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -33%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 100%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Biopharmaceutical R&D, and Targeted Therapies.
3 Weak multi-year price returns
2Y Excs Rtn is -39%, 3Y Excs Rtn is -72%
4 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.37, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 19%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -211 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2114%
6 Expensive valuation multiples
P/SPrice/Sales ratio is 102x
7 Stock price has recently run up significantly
12M Rtn12 month market price return is 121%
8 Weak revenue growth
Rev Chg QQuarterly Revenue Change % is null
9 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 263%
10 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1723%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -2074%
11 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 64%
12 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -41%
13 High stock price volatility
Vol 12M is 115%
14 Key risks
[ZBIO] key risks include [1] an extreme dependence on a limited product pipeline, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

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Zenas BioPharma (ZBIO) stock has gained about 5% since 1/31/2026 because of the following key factors:

1. Positive Clinical Trial Results and Regulatory Progress for Lead Asset.

Zenas BioPharma announced on March 16, 2026, that its lead asset, obexelimab, met its primary and all four key secondary endpoints with high statistical significance in the Phase 3 INDIGO trial for Immunoglobulin G4-Related Disease (IgG4-RD). The company plans to submit a Biologics License Application (BLA) to the FDA in the second quarter of 2026 and a Marketing Authorization Application (MAA) to the EMA in the second half of 2026 for obexelimab in IgG4-RD.

2. Significant Insider Buying Activity.

Between January and April 2026, Zenas BioPharma saw substantial insider buying, with total insider purchases exceeding $8.77 million within the last 90 days. Notably, CEO Leon O. Moulder Jr. made repeated and aggressive purchases, including nearly $3.7 million worth of company stock in three separate transactions from January to March 2026, and an additional purchase of approximately $1.07 million for 60,000 shares in late April 2026.

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Stock Movement Drivers

Fundamental Drivers

The 4.9% change in ZBIO stock from 1/31/2026 to 5/7/2026 was primarily driven by a 98.1% change in the company's P/S Multiple.
(LTM values as of)13120265072026Change
Stock Price ($)18.3719.274.9%
Change Contribution By: 
Total Revenues ($ Mil)1510-33.3%
P/S Multiple51.6102.398.1%
Shares Outstanding (Mil)4253-20.6%
Cumulative Contribution4.9%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 5/7/2026
ReturnCorrelation
ZBIO4.9% 
Market (SPY)3.6%13.5%
Sector (XLV)-6.1%33.6%

Fundamental Drivers

The -38.3% change in ZBIO stock from 10/31/2025 to 5/7/2026 was primarily driven by a -33.3% change in the company's Total Revenues ($ Mil).
(LTM values as of)103120255072026Change
Stock Price ($)31.2519.27-38.3%
Change Contribution By: 
Total Revenues ($ Mil)1510-33.3%
P/S Multiple87.2102.317.3%
Shares Outstanding (Mil)4253-21.1%
Cumulative Contribution-38.3%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 5/7/2026
ReturnCorrelation
ZBIO-38.3% 
Market (SPY)5.5%3.0%
Sector (XLV)1.2%13.5%

Fundamental Drivers

The 66.4% change in ZBIO stock from 4/30/2025 to 5/7/2026 was primarily driven by a 100.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)43020255072026Change
Stock Price ($)11.5819.2766.4%
Change Contribution By: 
Total Revenues ($ Mil)510100.0%
P/S Multiple96.8102.35.7%
Shares Outstanding (Mil)4253-21.3%
Cumulative Contribution66.4%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2025 to 5/7/2026
ReturnCorrelation
ZBIO66.4% 
Market (SPY)30.4%17.2%
Sector (XLV)4.9%23.8%

Fundamental Drivers

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Market Drivers

4/30/2023 to 5/7/2026
ReturnCorrelation
ZBIO  
Market (SPY)78.7%20.4%
Sector (XLV)13.9%19.8%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
ZBIO Return----55%343%-43%15%
Peers Return16%19%7%-1%27%4%92%
S&P 500 Return27%-19%24%23%16%8%96%

Monthly Win Rates [3]
ZBIO Win Rate---25%67%40% 
Peers Win Rate48%62%45%47%60%52% 
S&P 500 Win Rate75%42%67%75%67%60% 

Max Drawdowns [4]
ZBIO Max Drawdown----55%-21%-58% 
Peers Max Drawdown-7%-9%-19%-16%-14%-6% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: AMGN, BIIB, BMY, JNJ, LLY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/7/2026 (YTD)

How Low Can It Go

Event

Compare to AMGN, BIIB, BMY, JNJ, LLY

In The Past

Zenas BioPharma's stock fell 0.0% during the 2025 US Tariff Shock. Such a loss loss requires a 0.0% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

Event

Compare to AMGN, BIIB, BMY, JNJ, LLY

In The Past

Zenas BioPharma's stock fell 0.0% during the 2025 US Tariff Shock. Such a loss loss requires a 0.0% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Zenas BioPharma (ZBIO)

We are a clinical-stage global biopharmaceutical company committed to being a leader in the development and commercialization of transformative immunology-based therapies for patients in need. With the evolving understanding of the pathogenesis of autoimmune diseases, along with the expansion of promising immunology-based pharmacologic targets, we are building an immunology and inflammation (“I&I”) focused biopharmaceutical company. Our core business strategy combines disciplined product candidate acquisition with strategic deployment of internal expertise and effective use of external resources. We leverage our experienced executive management team and our established networks throughout the biopharmaceutical industry to identify, acquire and develop product candidates that we believe can provide superior clinical benefits to patients living with autoimmune diseases. Our lead I&I product candidate, obexelimab, is a bifunctional monoclonal antibody designed to bind both CD19 and Fcγ receptor IIb (“FcγRIIb”), which are broadly present across B cell lineage, in order to inhibit the activity of cells that are implicated in many autoimmune diseases without depleting them. Based on existing clinical data generated to date, we believe that targeting B cell lineage via CD19 and FcγRIIb can inhibit B cells and has been shown to be well-tolerated. While anti-CD20 or other anti-CD19 targeting agents effectively deplete B cells in systemic circulation, these agents do not fully impact B cells in relevant tissue, and the intermittent dosing regimens of these agents may not provide optimal benefits for all patients. In addition, anti-CD20 and other anti-CD19 targeting agents may cause prolonged depletion of circulating B cells for six months or longer, placing patients at higher risk of opportunistic infections and potentially reducing their ability to respond to, and receive full benefit from, vaccines. We believe obexelimab’s mechanism of action and chronic dosing regimen may broadly and effectively address the pathogenic role of B cell lineage in chronic autoimmune disease. Across five clinical trials, in which 198 subjects were dosed, obexelimab was well-tolerated and demonstrated clinical activity that we believe provides proof-of-concept (“POC”) for obexelimab as a B cell inhibitor for the treatment of patients living with certain autoimmune diseases and, together with its mechanism of action, positions obexelimab to be a potentially differentiated B cell therapy for the treatment of such patients. We are developing obexelimab as a potential I&I franchise for patients in several autoimmune diseases, representing substantial commercial opportunities individually and in the aggregate. The first four indications we are pursuing include immunoglobulin G4-related disease (“IgG4-RD”) through an ongoing registration-directed Phase 3 trial; multiple sclerosis (“MS”) and systemic lupus erythematosus (“SLE”) through Phase 2, double-blind, randomized, placebo-controlled trials each of which we initiated in the third quarter of 2024; and warm autoimmune hemolytic anemia (“wAIHA”) through an ongoing Phase 2/3 trial, currently in the Phase 2 open label portion. IgG4-RD is a chronic fibro-inflammatory condition that can affect virtually all organ systems, including the pancreas, biliary tract, salivary and lacrimal glands, lungs and kidneys. IgG4-RD is a relatively recently described disease that incorporates groups of manifestations that were diagnosed as separate disease entities prior to 2003. We estimate that the currently diagnosed population of IgG4-RD patients in the United States is approximately 20,000, with comparable prevalence rates globally. MS is the most common immune- mediated, chronic inflammatory demyelinating disease of the central nervous system (“CNS”), affecting over two million people worldwide including as many as 1,000,000 in the United States. We estimate a diagnosed prevalence of approximately 650,000 patients in the United States with MS. SLE, the most common form of lupus, is a complex, chronic autoimmune disease characterized most notably by unpredictable flares in joints, skin, kidneys and other vital organs that cause progressive organ damage. According to the Lupus Foundation of America, at least 1.5 million Americans are afflicted by lupus and more than 16,000 new cases are reported annually. It is estimated that five million people throughout the world suffer from some form of lupus, of which 70% suffer from the most common form, SLE. We estimate a diagnosed prevalence of approximately 245,000 patients in the United States having lupus, with approximately 172,000 having SLE. Autoimmune hemolytic anemia (“AIHA”) is an acquired disorder in which autoantibodies directed against a patient’s own red blood cell (“RBC”) membrane antigens lead to their accelerated destruction, and the rate of production of new cells in the bone marrow can no longer compensate for their loss. We estimate that the currently diagnosed population of wAIHA patients in the United States is approximately 40,000, with similar prevalence rates in other countries. We estimate that the commercial opportunity across these four indications is approximately $50 billion in the aggregate in the U.S. alone. To date, we have no product candidates approved for commercial sale in any country and have not generated any revenue from product sales. Zenas BioPharma, Inc. was originally incorporated on November 12, 2019, as Zenas BioPharma (Cayman) Limited as an exempted company organized under the laws of the Cayman Islands. On August 2, 2023, the Company was domesticated as a Delaware corporation and, concurrent therewith, we changed our name from Zenas BioPharma (Cayman) Limited to Zenas BioPharma, Inc. Our principal executive offices are located at 1000 Winter Street, Suite 1200, Waltham, MA 02451.

AI Analysis | Feedback

1. Zenas BioPharma is like a 'kinder, gentler' Biogen for B-cell autoimmune therapies, aiming to inhibit rather than deplete B cells.

2. Zenas BioPharma aims to be a future AbbVie for immunology franchises, starting with a novel B-cell inhibitor for multiple autoimmune conditions.

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Major Product Candidate

  • Obexelimab: A bifunctional monoclonal antibody in clinical development for the treatment of various autoimmune diseases, including IgG4-RD, multiple sclerosis, systemic lupus erythematosus, and warm autoimmune hemolytic anemia.

AI Analysis | Feedback

Because Zenas BioPharma is a clinical-stage biopharmaceutical company, it has no product candidates approved for commercial sale in any country and has not generated any revenue from product sales. Therefore, Zenas BioPharma currently has no major customers.

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Lonnie Moulder, Chief Executive Officer and Chairman of the Board of Directors

Mr. Moulder is the Founder of Zenas BioPharma and has served as its Chief Executive Officer since August 2023, and as Chairman and a member of the board of directors since 2020. He has been the Managing Member of Tellus BioVentures, LLC, an early-stage life sciences investment fund, since March 2019. Mr. Moulder has built and sold biotech companies for a combined total exceeding $10 billion, including the sale of TESARO to GlaxoSmithKline for $5.1 billion, Abraxis BioScience to Celgene for $2.9 billion, and MGI PHARMA to Eisai for $3.9 billion. He was recognized as Entrepreneur of the Year by Ernst & Young in 2017.

Jennifer Fox, Chief Business Officer and Chief Financial Officer

Ms. Fox has served as Zenas BioPharma's Chief Business Officer and Chief Financial Officer since December 2023. She is an experienced finance and corporate development executive with over 25 years of experience in corporate finance and healthcare investment banking, during which she advised numerous private and public companies on strategy, financings, and mergers and acquisitions. Prior to joining Zenas, Ms. Fox served as Chief Financial Officer at Nuvation Bio, Inc., a publicly traded biotechnology company. Before Nuvation Bio, she was a Managing Director and Co-Head of North America Healthcare Corporate and Investment Banking Group at CitiGroup, and also held senior investment banking positions at Deutsche Bank, Bear Stearns, Bank of America, and Prudential Securities.

Joe Farmer, President and Chief Operating Officer

Mr. Farmer serves as President and Chief Operating Officer. He is an accomplished biopharma executive with approximately 25 years of transactional and operational experience across all stages of development for emerging biotechnology companies, from discovery through commercialization. Prior to Zenas, Mr. Farmer was Chief Operating Officer at Xilio Therapeutics. Before Xilio, he served as General Counsel and Corporate Secretary at TESARO, where he led global legal, compliance, and government affairs functions and was a key member of the leadership team during its acquisition by GlaxoSmithKline in 2019.

Lisa von Moltke, M.D., Head of Research and Development and Chief Medical Officer

Dr. von Moltke was appointed Head of Research and Development and Chief Medical Officer at Zenas BioPharma in March 2025, bringing over three decades of experience in drug development with expertise in autoimmune diseases. She previously served as Chief Medical Officer at Seres Therapeutics, with functional oversight of clinical development, sciences and operations, regulatory, and medical affairs. Her career includes significant leadership roles at Alkermes, Inc., where she was Senior Vice President and Head of Clinical Development, and at Sanofi/Genzyme Corporation, where she served as Vice President, Clinical and Exploratory Pharmacology. Dr. von Moltke also served as President of the American College of Clinical Pharmacology.

Haley Laken, Ph.D., Chief Scientific Officer

Dr. Laken was appointed Chief Scientific Officer of Zenas BioPharma in April 2025. She brings over two decades of leadership experience in research, development operations, scientific assessment, and strategy. Before joining Zenas, Dr. Laken served as Chief Operating Officer at Tabby Therapeutics, a privately held biotech company. She held roles of increasing responsibility at Jounce Therapeutics, culminating as Chief Development Officer, and served in a senior program leadership role at TESARO, where she led multiple biologic development programs. Dr. Laken also held strategic drug development leadership roles at Rhythm Pharmaceuticals, Pfizer, and Wyeth.

AI Analysis | Feedback

The key risks for Zenas BioPharma (ZBIO) are:

  1. Clinical Trial and Regulatory Approval Risk: Zenas BioPharma is a clinical-stage company with no products approved for commercial sale and no revenue generated from product sales. The company's entire business and future revenue generation depend on the successful completion of clinical trials for its lead product candidate, obexelimab, across its various indications (IgG4-RD, MS, SLE, wAIHA), and subsequently obtaining regulatory approvals from health authorities. Failure in any of these critical stages due to issues with efficacy, safety, or other regulatory hurdles would fundamentally undermine the company's prospects.
  2. Product Candidate Concentration Risk: Zenas BioPharma's strategy is heavily centered on developing obexelimab as its lead "I&I franchise" product candidate for multiple autoimmune diseases. While pursuing several indications, the company's pipeline is currently reliant on the success of this single bifunctional monoclonal antibody. Should obexelimab fail to demonstrate sufficient efficacy or an acceptable safety profile, or encounter unforeseen development or commercialization challenges, the company's entire business model would be severely impacted due to its lack of other late-stage diversified product candidates.

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Zenas BioPharma (ZBIO) is developing obexelimab for several autoimmune diseases, with the following estimated addressable market sizes in the U.S.:
Product/Service Addressable Market Size Region
Obexelimab for Immunoglobulin G4-related disease (IgG4-RD) Approximately 20,000 diagnosed patients U.S.
Obexelimab for Multiple Sclerosis (MS) Approximately 650,000 diagnosed patients U.S.
Obexelimab for Systemic Lupus Erythematosus (SLE) Approximately 172,000 diagnosed patients U.S.
Obexelimab for Warm Autoimmune Hemolytic Anemia (wAIHA) Approximately 40,000 diagnosed patients U.S.
Aggregate Commercial Opportunity (Obexelimab across the four indications) Approximately $50 billion U.S.

AI Analysis | Feedback

The primary drivers of future revenue growth for Zenas BioPharma (ZBIO) over the next 2-3 years are centered on the successful development and commercialization of its lead product candidate, obexelimab, across multiple autoimmune disease indications:

  1. Successful Clinical Development and Regulatory Approval of Obexelimab for IgG4-RD: Zenas BioPharma is currently conducting a registration-directed Phase 3 trial for obexelimab in immunoglobulin G4-related disease (IgG4-RD). Successful completion of this trial and subsequent regulatory approval would mark the company's first potential product launch and revenue generation.
  2. Commercial Launch and Market Penetration of Obexelimab for IgG4-RD: Following regulatory approval for IgG4-RD, the effective commercial launch and successful market penetration of obexelimab within this indication will directly drive initial revenue growth. The company estimates a diagnosed population of approximately 20,000 IgG4-RD patients in the United States, representing a significant commercial opportunity upon launch.
  3. Advancement and Expansion of Obexelimab into Additional Autoimmune Disease Indications: Zenas BioPharma is also developing obexelimab for multiple sclerosis (MS) and systemic lupus erythematosus (SLE) through Phase 2 trials, and for warm autoimmune hemolytic anemia (wAIHA) through an ongoing Phase 2/3 trial. Positive clinical trial outcomes and progression of obexelimab into later-stage development and eventual approval in these indications, which represent significantly larger patient populations (estimated at 650,000 for MS, 172,000 for SLE, and 40,000 for wAIHA in the U.S.), would substantially expand obexelimab's total addressable market and serve as major drivers for sustained future revenue growth.

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Share Issuance

  • Zenas BioPharma completed an initial public offering (IPO) in September 2024, raising approximately $258.7 million in gross proceeds, including the full exercise of the underwriters' option to purchase additional shares. Net proceeds from the IPO totaled $234.4 million through the sale of 13.23 million shares at $17 per share.
  • In October 2025, the company secured a $120 million private placement by issuing approximately 6.3 million shares to institutional and accredited investors at $19.00 per share.
  • Prior to its IPO, Zenas BioPharma raised a total of $318 million across three funding rounds, with its largest, a Series C round, occurring in May 2024 for $200.15 million.

Inbound Investments

  • Zenas BioPharma entered into a revenue participation and funding agreement with Royalty Pharma, which will provide up to $300 million in consideration, including an upfront payment of $75 million.
  • The company successfully completed a Series C funding round in May 2024, raising $200.15 million, co-led by SR One, New Enterprise Associates, Norwest Venture Partners, and Delos Capital Partners.
  • A private placement completed in October 2025 brought in $120 million from institutional and accredited investors, as well as company directors and officers.

Outbound Investments

  • Zenas BioPharma made a strategic investment through a license agreement with InnoCare, which included a $35.0 million upfront payment for exclusive development and manufacturing rights for product candidates, such as orelabrutinib. A $5.0 million deposit related to this upfront payment was recognized as acquired in-process research and development expenses in the quarter ended September 30, 2025.

Capital Expenditures

  • Capital expenditures were reported as -$92,000 in the last 12 months, and $0.00 in the most recent quarter.
  • The company anticipates that its cash, cash equivalents, and investments will cover its operating expenses and capital expenditure requirements into the fourth quarter of 2026.
  • The primary focus of capital allocation is on supporting ongoing research and development activities and clinical trials for its lead product candidates, obexelimab and orelabrutinib.

Trade Ideas

Select ideas related to ZBIO.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
GEHC_4302026_Dip_Buyer_FCFYield04302026GEHCGE HealthCare TechnologiesDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
0.0%0.0%0.0%
IQV_4302026_Dip_Buyer_FCFYield04302026IQVIQVIADip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
0.0%0.0%0.0%
UHS_4302026_Dip_Buyer_FCFYield04302026UHSUniversal Health ServicesDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
0.0%0.0%0.0%
ABT_4302026_Dip_Buyer_ValueBuy04302026ABTAbbott LaboratoriesDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
0.0%0.0%0.0%
ZBIO_4302026_Insider_Buying_45D_2Buy_200K04302026ZBIOZenas BioPharmaInsiderInsider Buys 45DStrong Insider Buying
Companies with multiple insider buys in the last 45 days
0.0%0.0%0.0%
ZBIO_10312025_Insider_Buying_45D_2Buy_200K10312025ZBIOZenas BioPharmaInsiderInsider Buys 45DStrong Insider Buying
Companies with multiple insider buys in the last 45 days
-38.2%-38.2%-51.4%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

ZBIOAMGNBIIBBMYJNJLLYMedian
NameZenas Bi.Amgen Biogen Bristol-.Johnson .Eli Lilly 
Mkt Price19.27329.09191.3856.25222.51974.96206.94
Mkt Cap1.0177.728.2114.6536.0872.1146.2
Rev LTM1037,2209,93748,48396,36272,25042,852
Op Inc LTM-21110,5682,30413,59125,79234,17212,080
FCF LTM-2078,5972,31611,90817,41310,3689,482
FCF 3Y Avg-1198,8701,96512,50118,0741,7345,418
CFO LTM-17210,7562,59113,30622,87020,48012,031
CFO 3Y Avg-10810,3482,27213,78023,61511,15810,753

Growth & Margins

ZBIOAMGNBIIBBMYJNJLLYMedian
NameZenas Bi.Amgen Biogen Bristol-.Johnson .Eli Lilly 
Rev Chg LTM100.0%9.1%1.2%1.8%7.9%47.4%8.5%
Rev Chg 3Y Avg-12.5%-0.5%1.9%4.4%37.9%4.4%
Rev Chg Q-100.0%5.8%1.9%2.6%9.9%55.5%4.2%
QoQ Delta Rev Chg LTM-33.3%1.3%0.5%0.6%2.3%10.8%0.9%
Op Inc Chg LTM-29.0%41.9%-1.1%72.7%20.7%73.3%31.3%
Op Inc Chg 3Y Avg-8.8%-3.4%21.0%5.7%67.4%8.8%
Op Mgn LTM-2,113.8%28.4%23.2%28.0%26.8%47.3%27.4%
Op Mgn 3Y Avg-1,815.3%24.6%22.2%20.2%25.6%39.7%23.4%
QoQ Delta Op Mgn LTM-809.2%3.7%-1.8%-0.4%-0.4%1.7%-0.4%
CFO/Rev LTM-1,723.3%28.9%26.1%27.4%23.7%28.3%26.8%
CFO/Rev 3Y Avg-1,392.6%30.7%23.1%29.2%26.2%19.2%24.7%
FCF/Rev LTM-2,073.5%23.1%23.3%24.6%18.1%14.4%20.6%
FCF/Rev 3Y Avg-1,510.2%26.4%20.0%26.5%20.1%0.3%20.0%

Valuation

ZBIOAMGNBIIBBMYJNJLLYMedian
NameZenas Bi.Amgen Biogen Bristol-.Johnson .Eli Lilly 
Mkt Cap1.0177.728.2114.6536.0872.1146.2
P/S102.34.82.82.45.612.15.2
P/Op Inc-4.816.812.28.420.825.514.5
P/EBIT-2.815.114.810.120.624.415.0
P/E-2.722.820.515.825.534.521.7
P/CFO-5.916.510.98.623.442.613.7
Total Yield-36.9%7.3%4.9%10.8%6.3%3.5%5.6%
Dividend Yield0.0%2.9%0.0%4.4%2.3%0.6%1.5%
FCF Yield 3Y Avg-5.2%8.1%10.5%4.1%0.2%5.2%
D/E0.00.30.20.40.10.00.2
Net D/E-0.30.30.10.30.10.00.1

Returns

ZBIOAMGNBIIBBMYJNJLLYMedian
NameZenas Bi.Amgen Biogen Bristol-.Johnson .Eli Lilly 
1M Rtn-14.3%-3.2%9.0%-2.5%-6.7%4.7%-2.8%
3M Rtn-8.3%-9.9%3.2%-4.5%-5.9%-4.3%-5.2%
6M Rtn-40.6%5.7%22.1%23.3%20.4%4.3%13.1%
12M Rtn121.0%23.0%63.3%24.0%45.4%26.5%35.9%
3Y Rtn6.2%54.1%-39.1%-5.5%49.9%130.4%28.0%
1M Excs Rtn-15.8%-14.1%-1.8%-13.2%-16.0%-5.9%-13.6%
3M Excs Rtn-16.2%-17.8%-4.7%-12.4%-13.9%-12.3%-13.1%
6M Excs Rtn-44.0%4.1%19.8%17.8%12.1%-0.5%8.1%
12M Excs Rtn82.7%-5.4%33.0%-6.7%17.2%-4.1%6.5%
3Y Excs Rtn-71.9%-24.9%-116.2%-83.2%-30.7%68.5%-51.3%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil202520242023
Research and development of precision immunology-based therapies5 0
Total5 0


Net Income by Segment
$ Mil202520242023
Research and development of precision immunology-based therapies-157  
Total-157  


Assets by Segment
$ Mil202520242023
Research and development of precision immunology-based therapies 6875
Total 6875


Price Behavior

Price Behavior
Market Price$19.27 
Market Cap ($ Bil)1.0 
First Trading Date09/13/2024 
Distance from 52W High-55.4% 
   50 Days200 Days
DMA Price$21.85$22.60
DMA Trendupdown
Distance from DMA-11.8%-14.8%
 3M1YR
Volatility75.7%115.2%
Downside Capture0.950.95
Upside Capture96.77225.29
Correlation (SPY)16.4%15.8%
ZBIO Betas & Captures as of 4/30/2026

 1M2M3M6M1Y3Y
Beta0.781.520.700.191.590.28
Up Beta-0.90-0.83-0.42-0.950.30-0.26
Down Beta-1.882.400.490.000.951.76
Up Capture157%103%89%-6%432%56%
Bmk +ve Days15223166141428
Stock +ve Days12203267135207
Down Capture1312%323%160%101%169%100%
Bmk -ve Days4183056108321
Stock -ve Days10233258116198

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ZBIO
ZBIO123.6%115.2%1.29-
Sector ETF (XLV)9.7%15.4%0.4021.3%
Equity (SPY)29.6%12.5%1.8615.5%
Gold (GLD)37.0%27.1%1.147.9%
Commodities (DBC)48.7%18.0%2.12-2.4%
Real Estate (VNQ)12.9%13.5%0.6511.2%
Bitcoin (BTCUSD)-16.3%42.1%-0.3114.5%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ZBIO
ZBIO2.1%110.4%0.60-
Sector ETF (XLV)5.3%14.6%0.1819.7%
Equity (SPY)12.8%17.1%0.5920.3%
Gold (GLD)21.1%17.9%0.965.5%
Commodities (DBC)14.1%19.1%0.600.4%
Real Estate (VNQ)3.3%18.8%0.0813.8%
Bitcoin (BTCUSD)7.0%56.0%0.3415.4%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ZBIO
ZBIO1.0%110.4%0.60-
Sector ETF (XLV)9.3%16.5%0.4519.7%
Equity (SPY)15.0%17.9%0.7220.3%
Gold (GLD)13.5%16.0%0.705.5%
Commodities (DBC)9.4%17.8%0.440.4%
Real Estate (VNQ)5.7%20.7%0.2413.8%
Bitcoin (BTCUSD)68.2%66.9%1.0715.4%

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Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity10.2 Mil
Short Interest: % Change Since 33120269.2%
Average Daily Volume0.8 Mil
Days-to-Cover Short Interest12.4 days
Basic Shares Quantity53.1 Mil
Short % of Basic Shares19.3%

Earnings Returns History

Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/16/2026-3.4%-7.2%-11.2%
11/12/20251.7%2.9%15.3%
8/12/20256.7%15.9%32.8%
5/15/202512.2%26.0%19.0%
2/5/20253.4%-5.1%-5.1%
11/12/2024-3.1%-29.1%-56.9%
SUMMARY STATS   
# Positive433
# Negative233
Median Positive5.0%15.9%19.0%
Median Negative-3.2%-7.2%-11.2%
Max Positive12.2%26.0%32.8%
Max Negative-3.4%-29.1%-56.9%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/16/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/15/202510-Q
12/31/202403/11/202510-K
09/30/202411/12/202410-Q
06/30/202409/13/2024424B4
03/31/202406/26/2024DRS/A
09/30/202301/25/2024DRS

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Moulder, Leon O JRChief Executive OfficerSee FootnoteBuy429202617.6235,000616,70031,470,007Form
2Moulder, Leon O JRChief Executive OfficerSee FootnoteBuy429202618.0225,000450,50031,553,723Form
3Lu, HongboSee footnoteBuy402202618.633,76870,1987,950,092Form
4Moulder, Leon O JRChief Executive OfficerSee FootnoteBuy331202619.3134,000656,54033,329,813Form
5Lu, HongboSee footnoteBuy331202620.0075,0001,500,0008,459,360Form