Tearsheet

Harmony Biosciences (HRMY)


Market Price (12/24/2025): $38.415 | Market Cap: $2.2 Bil
Sector: Health Care | Industry: Biotechnology

Harmony Biosciences (HRMY)


Market Price (12/24/2025): $38.415
Market Cap: $2.2 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 8.4%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 4.2%, FCF Yield is 13%
Weak multi-year price returns
2Y Excs Rtn is -30%, 3Y Excs Rtn is -110%
Key risks
HRMY key risks include [1] its substantial dependence on a single product, Show more.
1 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -23%
  
2 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%
  
3 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 36%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 36%
  
4 Low stock price volatility
Vol 12M is 42%
  
5 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Biopharmaceutical R&D, and Targeted Therapies.
  
0 Attractive yield
Total YieldTotal Yield = Earnings Yield + Dividend Yield, Earnings Yield = Net Income / Market Cap Dividend Yield = Total Dividends / Market Cap is 8.4%, ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is 4.2%, FCF Yield is 13%
1 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -23%
2 Attractive operating margins
Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is 27%
3 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 36%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 36%
4 Low stock price volatility
Vol 12M is 42%
5 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Biopharmaceutical R&D, and Targeted Therapies.
6 Weak multi-year price returns
2Y Excs Rtn is -30%, 3Y Excs Rtn is -110%
7 Key risks
HRMY key risks include [1] its substantial dependence on a single product, Show more.

Valuation, Metrics & Events

HRMY Stock


Why The Stock Moved


Qualitative Assessment

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1. Harmony Biosciences preannounced strong preliminary Q3 2025 financial results and significantly raised its full-year 2025 revenue guidance. The WAKIX® (pitolisant) franchise delivered approximately $239 million in net revenue for Q3 2025, marking a 29% year-over-year growth. This robust performance led the company to increase its 2025 revenue guidance to a range of $845-$865 million, up from the previous $820-$860 million. This news was associated with a 12.7% increase in the stock on October 24, 2025.

2. The company reported solid Q2 2025 financial results, setting a positive tone for the second half of the year. Harmony Biosciences announced net product revenue of $200.5 million for Q2 2025, representing a 16% year-over-year increase, primarily driven by strong WAKIX sales. The company also reaffirmed its 2025 revenue guidance at that time.

Show more

Stock Movement Drivers

Fundamental Drivers

The 19.9% change in HRMY stock from 9/23/2025 to 12/23/2025 was primarily driven by a 16.9% change in the company's P/E Multiple.
923202512232025Change
Stock Price ($)32.0738.4419.86%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)772.53825.946.91%
Net Income Margin (%)23.42%22.48%-4.00%
P/E Multiple10.1911.9116.95%
Shares Outstanding (Mil)57.4757.55-0.14%
Cumulative Contribution19.86%

LTM = Last Twelve Months as of date shown

Market Drivers

9/23/2025 to 12/23/2025
ReturnCorrelation
HRMY19.9% 
Market (SPY)3.7%10.4%
Sector (XLV)13.2%12.6%

Fundamental Drivers

The 19.9% change in HRMY stock from 6/24/2025 to 12/23/2025 was primarily driven by a 10.9% change in the company's Total Revenues ($ Mil).
624202512232025Change
Stock Price ($)32.0638.4419.90%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)744.85825.9410.89%
Net Income Margin (%)20.50%22.48%9.64%
P/E Multiple12.0311.91-0.97%
Shares Outstanding (Mil)57.3157.55-0.42%
Cumulative Contribution19.90%

LTM = Last Twelve Months as of date shown

Market Drivers

6/24/2025 to 12/23/2025
ReturnCorrelation
HRMY19.9% 
Market (SPY)13.7%16.7%
Sector (XLV)16.4%20.6%

Fundamental Drivers

The 10.0% change in HRMY stock from 12/23/2024 to 12/23/2025 was primarily driven by a 25.0% change in the company's Net Income Margin (%).
1223202412232025Change
Stock Price ($)34.9538.449.99%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)681.88825.9421.13%
Net Income Margin (%)17.98%22.48%25.01%
P/E Multiple16.2111.91-26.49%
Shares Outstanding (Mil)56.8757.55-1.20%
Cumulative Contribution9.97%

LTM = Last Twelve Months as of date shown

Market Drivers

12/23/2024 to 12/23/2025
ReturnCorrelation
HRMY10.0% 
Market (SPY)16.7%24.3%
Sector (XLV)13.2%28.8%

Fundamental Drivers

The -32.2% change in HRMY stock from 12/24/2022 to 12/23/2025 was primarily driven by a -44.8% change in the company's P/E Multiple.
1224202212232025Change
Stock Price ($)56.7038.44-32.20%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)400.76825.94106.09%
Net Income Margin (%)38.84%22.48%-42.13%
P/E Multiple21.5711.91-44.78%
Shares Outstanding (Mil)59.2357.552.84%
Cumulative Contribution-32.26%

LTM = Last Twelve Months as of date shown

Market Drivers

12/24/2023 to 12/23/2025
ReturnCorrelation
HRMY19.6% 
Market (SPY)48.4%25.0%
Sector (XLV)18.2%25.3%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
HRMY Return�18%29%-41%7%13%�
Peers Return0%-25%30%20%-6%36%50%
S&P 500 Return16%27%-19%24%23%17%114%

Monthly Win Rates [3]
HRMY Win Rate50%42%58%50%58%58% 
Peers Win Rate45%52%58%52%47%60% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
HRMY Max Drawdown�-29%-22%-65%-11%-25% 
Peers Max Drawdown-39%-40%-22%-18%-24%-19% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: JAZZ, AXSM, ALKS, NBIX, ACAD.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/23/2025 (YTD)

How Low Can It Go

Unique KeyEventHRMYS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-68.5%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven217.2%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-30.5%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven44.0%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven482 days148 days

Compare to VRTX, ACSB, ALPS, APRI, CRMO

In The Past

Harmony Biosciences's stock fell -68.5% during the 2022 Inflation Shock from a high on 12/5/2022. A -68.5% loss requires a 217.2% gain to breakeven.

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About Harmony Biosciences (HRMY)

Harmony Biosciences Holdings, Inc., a commercial-stage pharmaceutical company, develops and commercializes therapies for patients with rare neurological disorders in the United States. Its product, WAKIX is a medication for the treatment of excessive daytime sleepiness in adult patients with narcolepsy. The company was formerly known as Harmony Biosciences II, Inc. and changed its name to Harmony Biosciences Holdings, Inc. in February 2020. Harmony Biosciences Holdings, Inc. was incorporated in 2017 and is based in Plymouth Meeting, Pennsylvania.

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A younger Jazz Pharmaceuticals, specializing in treatments for narcolepsy and other rare neurological conditions.

Like a Sarepta Therapeutics, but focused on rare neurological disorders instead of muscular dystrophies.

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  • Wakix (pitolisant): An oral medication approved to treat excessive daytime sleepiness (EDS) and cataplexy in adult patients with narcolepsy.

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Harmony Biosciences (HRMY) primarily sells its pharmaceutical products to other companies within the healthcare supply chain, rather than directly to individuals. While Harmony Biosciences does not explicitly name its major customers in its public filings, their SEC reports (e.g., 10-K) indicate that they distribute their products through a limited number of specialty pharmacies and third-party logistics providers. These filings also reveal significant customer concentration, with one customer accounting for approximately 70% of the company's gross product sales in 2023, and another for approximately 19%. Based on the typical pharmaceutical industry distribution model, these major customers are highly likely to be large pharmaceutical wholesalers and specialty distributors that manage the logistics and distribution of medications to pharmacies, hospitals, and other healthcare providers. The most probable candidates for such major customers in the U.S. pharmaceutical market include:
  • Cencora (formerly AmerisourceBergen) (Symbol: NYSE: ABC)
  • McKesson Corporation (Symbol: NYSE: MCK)
  • Cardinal Health (Symbol: NYSE: CAH)

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  • Bioprojet SCR
  • Fareva Amboise

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Jeffrey M. Dayno, M.D., President and Chief Executive Officer

Dr. Jeffrey M. Dayno is the President and Chief Executive Officer of Harmony Biosciences, having been appointed to the role in January 2023. He previously served as the Interim President and CEO since January 2023, and as Chief Medical Officer and Executive Vice President since the company's founding in 2017. A nationally recognized expert in neuroscience, Dr. Dayno is responsible for overseeing Harmony's business growth, which includes the acquisitions of Zynerba Pharmaceuticals in 2023 and Epygenix Therapeutics, Inc. in 2024. He played a critical role in the FDA approval of Harmony's key asset, WAKIX (pitolisant), and helped shape the company's commercial strategy. Before joining Harmony, Dr. Dayno spent 10 years in clinical and academic medicine as a neurologist, followed by over 25 years in the pharmaceutical industry, holding leadership roles at companies such as Merck & Co., Cephalon, and ViroPharma. Harmony Biosciences was established by Paragon Biosciences, LLC, a global life science leader that creates, builds, and funds innovative biology-based companies.

Sandip Kapadia, CPA, MBA, Chief Financial Officer and Chief Administrative Officer

Sandip Kapadia serves as the Chief Financial Officer and Chief Administrative Officer for Harmony Biosciences. He brings over 25 years of experience in the life sciences industry, providing strategic financial oversight and guidance to companies in both the United States and Europe. Most recently, Mr. Kapadia was the Chief Financial Officer at Intercept Pharmaceuticals, Inc. from July 2016 to March 2021, where he significantly contributed to building key functional capabilities, developing and executing financial and capital strategies for commercial launch, and raising over $700 million in various financings. Prior to Intercept, he spent the majority of his career at Novartis and its affiliates, holding various positions, including Chief Financial Officer of North America at Sandoz, Novartis's generic division. Mr. Kapadia is a Certified Public Accountant and holds an MBA from Rutgers University. He currently serves on the board of directors of Passage Bio, Inc., Molecular Partners AG, and VectivBio Holding AG.

Kumar Budur, MD, MS, Chief Medical and Scientific Officer

Dr. Kumar Budur is the Chief Medical and Scientific Officer at Harmony Biosciences. In this role, he leads the company's Research and Development (R&D) strategy and Medical Affairs, overseeing areas such as Clinical Strategy, Clinical Operations, Regulatory Affairs, Pharmacovigilance, Biostatistics, Portfolio Management, and Medical Affairs. Before joining Harmony Biosciences, Dr. Budur held positions of increasing responsibility for approximately six years at both AbbVie and Takeda. He is recognized as an expert in R&D, having overseen programs from late discovery to post-marketing studies and having experience with small molecules, biologics, and drug-device combinations. Dr. Budur was involved with four New Drug Applications (NDAs) and was the lead for the registration clinical trials, submission, and approval process of two NDAs.

Adam Zaeske, MBA, Executive Vice President and Chief Commercial Officer

Adam Zaeske serves as the Executive Vice President and Chief Commercial Officer at Harmony Biosciences. He has over 25 years of experience in building teams and transforming organizations across the US and Europe. His background encompasses a broad range of functions, including marketing, sales, market access, new product planning, and finance. Mr. Zaeske has successfully led and launched products in more than a dozen therapeutic areas, including orphan and cell & gene therapies. Before joining Harmony, he was the Head of Central, South and East Europe for Takeda Pharmaceuticals, where he led a region with over $2 billion USD in revenue and nearly 900 employees. He also previously served as Takeda's Head of Portfolio & Pipeline.

Andrew Serafin, JD, MBA, Chief Strategy Officer

Andrew Serafin is the Chief Strategy Officer at Harmony Biosciences. He is responsible for guiding the company's corporate strategy, business and corporate development initiatives, and alliance management efforts. This includes expanding Harmony's pipeline through the acquisition and licensing of novel rare disease therapies. Mr. Serafin brings 20 years of experience in mergers and acquisitions and corporate legal counseling within the pharmaceutical, broader healthcare, and technology sectors. He holds a Bachelor of Science degree from the University of Illinois, a Juris Doctor from the Loyola University Chicago School of Law, and a Master of Business Administration from the Northwestern University Kellogg School of Management.

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The primary business risks for Harmony Biosciences (HRMY) revolve around its reliance on its flagship product, market competition, and the inherent challenges of pharmaceutical development.

  1. High Dependence on WAKIX (Pitolisant): Harmony Biosciences is substantially dependent on the commercial success of WAKIX (pitolisant), which currently serves as its primary revenue source. Any factors leading to a decline in WAKIX sales, such as increased competition, unexpected safety issues, or failure to secure approval for new indications, could significantly impact the company's financial performance and revenue generation.
  2. Intense Market Competition: Harmony Biosciences operates in a highly competitive biopharmaceutical sector, particularly within the narcolepsy treatment market. The company faces ongoing competition from established pharmaceutical companies like Jazz Pharmaceuticals and Avadel Pharmaceuticals, as well as from emerging innovative therapies, including new orexin receptor 2 agonists under development by companies such as Alkermes and Takeda. The potential emergence of generic alternatives to existing treatments also poses a competitive threat. This competitive landscape could pressure WAKIX's market share and pricing.
  3. Clinical Trial Failures and Regulatory Setbacks: Harmony Biosciences' future growth and diversification heavily rely on the successful development and regulatory approval of pipeline assets and new indications for WAKIX. The company has experienced setbacks, including the failure of a Phase 3 study for ZYN002 in Fragile X syndrome and a Refusal to File letter from the FDA for a supplemental New Drug Application for pitolisant in idiopathic hypersomnia. Such failures and delays in clinical trials or regulatory processes can hinder product diversification, delay market entry, and negatively affect future revenue potential and investor confidence.

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The clear emerging threat for Harmony Biosciences is the potential market entry of Axsome Therapeutics' AXS-12.

AXS-12 is an investigational drug for the treatment of narcolepsy, directly targeting the same indication as Harmony Biosciences' primary product, WAKIX (pitolisant). Axsome Therapeutics is currently conducting a Phase 3 trial (SYMPHONY) for AXS-12, with topline results expected in the second half of 2024. If successful, AXS-12 could offer a new treatment option for narcolepsy, potentially with a different efficacy or safety profile, which could compete directly for market share with WAKIX.

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Harmony Biosciences (HRMY) primarily focuses on rare neurological disorders, with its main product being WAKIX® (pitolisant) tablets. The company's operations and revenue generation are conducted within the United States. Here's an overview of the addressable markets for their main products and services:

WAKIX® (pitolisant)

WAKIX is approved by the U.S. Food and Drug Administration (FDA) for the treatment of excessive daytime sleepiness (EDS) or cataplexy in adult patients with narcolepsy, and for the treatment of EDS in pediatric patients 6 years of age and older with narcolepsy.
  • U.S. Narcolepsy Therapeutics Market: The U.S. narcolepsy therapeutics market was valued at approximately $1.186 billion in 2023 and is projected to reach around $1.867 billion by 2030. Another estimate places the U.S. narcolepsy therapeutics market at $1.018 billion in 2024, growing to approximately $2.166 billion by 2034. The market opportunity for diagnosed narcolepsy patients in the U.S. is approximately 80,000 individuals.
Harmony Biosciences is also developing pitolisant for other indications, including idiopathic hypersomnia.
  • Global Idiopathic Hypersomnia Treatment Market: The global idiopathic hypersomnia treatment market reached $1.5 billion in 2024 and is expected to grow to $2.8 billion by 2031. North America holds a significant share, dominating the idiopathic hypersomnia treatment market with 50.5% in 2024.

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Harmony Biosciences (HRMY) is expected to drive future revenue growth over the next 2-3 years through several key strategic initiatives:
  • Sustained Market Penetration and Increased Patient Base for WAKIX in Narcolepsy: Harmony Biosciences continues to report strong demand and a growing patient base for its flagship product, WAKIX (pitolisant), for the treatment of narcolepsy. The company has consistently achieved record quarterly increases in the average number of patients on WAKIX, and management expects the drug to reach "blockbuster status," generating over $1 billion in annual revenue in narcolepsy alone.
  • Launch of Next-Generation Pitolisant Formulations and Expansion into New Indications: Harmony Biosciences is advancing new formulations of pitolisant, including Pitolisant GR (gastro-resistant) and Pitolisant HD (high-dose/optimized pharmacokinetic profile). These next-generation formulations are designed to offer improved characteristics and extend the product's lifecycle, with patent protection for Pitolisant GR expected out to 2044. Additionally, the company is evaluating pitolisant for new indications, such as idiopathic hypersomnia, with Phase 3 trials for Pitolisant HD in this area expected to commence in Q4 2025.
  • Advancement and Potential Commercialization of Novel Pipeline Assets: Harmony Biosciences is diversifying its pipeline beyond the current pitolisant franchise by developing new product candidates. A significant driver is BP1.15205, a highly potent and selective oral orexin-2 receptor agonist, which is an investigational compound for narcolepsy and other sleep/wake disorders. The first subject for BP1.15205 is expected to be dosed in Q4 2025. The company has also expanded its focus into rare epilepsies through strategic acquisitions, adding assets like EPX-100, which is in registrational Phase 3 trials. These new pipeline programs aim to address unmet medical needs in various neurological disorders and offer substantial future revenue potential.

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Share Repurchases

  • Harmony Biosciences' Board of Directors authorized a share repurchase program of up to $125 million on August 1, 2023.

Share Issuance

  • Harmony Biosciences completed its initial public offering (IPO) on August 21, 2020, issuing 6,151,162 shares of common stock at $24.00 per share, resulting in gross proceeds of $147.6 million.
  • Shares issued amounted to $2.1 million for the quarter ended June 2025.
  • As of September 30, 2025, diluted shares outstanding were 58,717,910.

Capital Expenditures

  • Capital expenditures were $0.30 million in 2021, $0.17 million in 2022, $37 million in 2023, and $34 million in 2024.

Better Bets than Harmony Biosciences (HRMY)

Trade Ideas

Select ideas related to HRMY. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
20.9%20.9%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.4%-7.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
13.5%13.5%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
1.6%1.6%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
11.8%11.8%-5.1%

Recent Active Movers

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Peer Comparisons for Harmony Biosciences

Peers to compare with:

Financials

HRMYJAZZAXSMALKSNBIXACADMedian
NameHarmony .Jazz Pha.Axsome T.Alkermes Neurocri.ACADIA P. 
Mkt Price38.44169.47154.1928.49147.2827.8392.86
Mkt Cap2.210.37.74.714.64.76.2
Rev LTM8264,1585611,5212,6831,0471,284
Op Inc LTM226454-19535955494292
FCF LTM2971,239-10149159399394
FCF 3Y Avg2291,069-12635347370291
CFO LTM2981,392-101541637199419
CFO 3Y Avg2291,274-125397508103313

Growth & Margins

HRMYJAZZAXSMALKSNBIXACADMedian
NameHarmony .Jazz Pha.Axsome T.Alkermes Neurocri.ACADIA P. 
Rev Chg LTM21.1%4.1%65.8%1.1%19.6%12.7%16.1%
Rev Chg 3Y Avg27.4%5.1%296.0%12.1%24.6%27.8%26.0%
Rev Chg Q28.7%6.7%63.2%4.2%27.8%11.3%19.5%
QoQ Delta Rev Chg LTM6.9%1.7%13.4%1.1%6.9%2.8%4.8%
Op Mgn LTM27.3%10.9%-34.7%23.6%20.6%9.0%15.8%
Op Mgn 3Y Avg29.9%14.3%-63.2%24.7%22.1%-1.1%18.2%
QoQ Delta Op Mgn LTM-1.4%-4.1%7.3%-1.3%0.8%0.2%-0.6%
CFO/Rev LTM36.0%33.5%-18.0%35.6%23.7%19.0%28.6%
CFO/Rev 3Y Avg33.2%32.0%-40.3%25.9%22.6%8.7%24.3%
FCF/Rev LTM35.9%29.8%-18.1%32.3%22.1%9.5%26.0%
FCF/Rev 3Y Avg33.2%26.8%-40.4%23.1%21.1%5.5%22.1%

Valuation

HRMYJAZZAXSMALKSNBIXACADMedian
NameHarmony .Jazz Pha.Axsome T.Alkermes Neurocri.ACADIA P. 
Mkt Cap2.210.37.74.714.64.76.2
P/S2.72.513.73.15.54.53.8
P/EBIT9.0-20.5-34.611.625.149.810.3
P/E11.9-27.9-33.613.934.218.012.9
P/CFO7.47.4-76.48.723.023.68.1
Total Yield8.4%-3.6%-3.0%7.2%2.9%5.6%4.2%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg12.3%14.1%-3.0%7.4%3.8%2.7%5.6%
D/E0.10.50.00.00.00.00.0
Net D/E-0.20.3-0.0-0.2-0.0-0.2-0.1

Returns

HRMYJAZZAXSMALKSNBIXACADMedian
NameHarmony .Jazz Pha.Axsome T.Alkermes Neurocri.ACADIA P. 
1M Rtn12.0%-4.2%3.2%-0.4%3.8%18.1%3.5%
3M Rtn19.9%31.0%30.5%2.7%0.6%17.9%18.9%
6M Rtn19.9%56.8%47.9%-2.9%14.9%24.2%22.0%
12M Rtn10.0%36.4%77.3%-3.4%7.5%62.1%23.2%
3Y Rtn-32.2%7.8%109.0%20.2%22.4%79.9%21.3%
1M Excs Rtn7.4%-8.9%-1.5%-5.1%-0.8%13.5%-1.1%
3M Excs Rtn39.6%26.7%25.7%-1.6%-3.7%26.8%26.2%
6M Excs Rtn8.3%44.8%35.3%-14.8%1.8%10.3%9.3%
12M Excs Rtn-4.3%20.2%54.0%-22.7%-8.6%48.6%7.9%
3Y Excs Rtn-110.3%-71.9%17.3%-59.3%-53.7%1.5%-56.5%

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA211150  WAKIXpitolisant hydrochloridetablet8142019     

Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Net product revenue5824383051606
Total5824383051606


Price Behavior

Price Behavior
Market Price$38.44 
Market Cap ($ Bil)2.2 
First Trading Date08/19/2020 
Distance from 52W High-5.1% 
   50 Days200 Days
DMA Price$33.48$33.11
DMA Trendindeterminateup
Distance from DMA14.8%16.1%
 3M1YR
Volatility50.9%42.3%
Downside Capture80.1267.22
Upside Capture152.5366.21
Correlation (SPY)11.4%24.5%
HRMY Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta0.080.270.390.730.530.80
Up Beta0.300.620.970.970.480.53
Down Beta-1.710.28-0.75-0.370.470.55
Up Capture201%113%50%89%46%72%
Bmk +ve Days13263974142427
Stock +ve Days13223062124359
Down Capture-71%-61%100%129%75%106%
Bmk -ve Days7162452107323
Stock -ve Days6193261119383

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of HRMY With Other Asset Classes (Last 1Y)
 HRMYSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return14.8%14.9%18.8%72.9%9.0%3.7%-11.4%
Annualized Volatility42.2%17.3%19.5%19.2%15.3%17.2%35.0%
Sharpe Ratio0.440.640.762.720.360.05-0.14
Correlation With Other Assets 28.9%24.4%1.5%9.2%33.6%10.9%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
 Comparison of HRMY With Other Asset Classes (Last 5Y)
 HRMYSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-0.8%8.4%14.8%18.9%11.8%4.7%35.5%
Annualized Volatility50.9%14.5%17.1%15.5%18.7%18.9%48.9%
Sharpe Ratio0.180.400.700.980.510.160.62
Correlation With Other Assets 26.4%26.8%-2.4%-0.1%24.3%15.0%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of HRMY With Other Asset Classes (Last 10Y)
 HRMYSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return0.7%9.9%14.8%15.1%6.8%5.4%69.1%
Annualized Volatility53.2%16.6%18.0%14.8%17.6%20.8%55.8%
Sharpe Ratio0.230.490.710.850.310.230.90
Correlation With Other Assets 26.7%26.9%-2.3%1.9%23.8%13.8%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date11282025
Short Interest: Shares Quantity4,412,922
Short Interest: % Change Since 111520253.0%
Average Daily Volume827,410
Days-to-Cover Short Interest5.33
Basic Shares Quantity57,550,902
Short % of Basic Shares7.7%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/23/202512.7%11.6%27.1%
8/5/2025-1.7%-2.1%5.6%
5/6/20257.0%19.0%17.4%
1/13/20257.6%15.3%11.5%
10/29/202416.1%-7.6%-2.6%
8/6/20246.2%8.1%16.6%
2/22/2024-4.7%0.8%1.7%
10/31/202319.4%26.5%49.2%
...
SUMMARY STATS   
# Positive121211
# Negative667
Median Positive7.3%9.9%16.6%
Median Negative-4.3%-6.4%-7.0%
Max Positive19.4%26.5%49.2%
Max Negative-11.1%-9.8%-12.0%

SEC Filings

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Report DateFiling DateFiling
93020251104202510-Q 9/30/2025
6302025805202510-Q 6/30/2025
3312025506202510-Q 3/31/2025
12312024225202510-K 12/31/2024
93020241029202410-Q 9/30/2024
6302024806202410-Q 6/30/2024
3312024430202410-Q 3/31/2024
12312023222202410-K 12/31/2023
93020231031202310-Q 9/30/2023
6302023801202310-Q 6/30/2023
3312023502202310-Q 3/31/2023
12312022221202310-K 12/31/2022
93020221101202210-Q 9/30/2022
6302022802202210-Q 6/30/2022
3312022503202210-Q 3/31/2022
12312021228202210-K 12/31/2021