Tearsheet

Kalaris Therapeutics (KLRS)


Market Price (4/23/2026): $6.34 | Market Cap: $123.3 Mil
Sector: Health Care | Industry: Biotechnology

Kalaris Therapeutics (KLRS)


Market Price (4/23/2026): $6.34
Market Cap: $123.3 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -95%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -87%, 3Y Excs Rtn is -117%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 14.58

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -46 Mil

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -39%

High stock price volatility
Vol 12M is 112%

Key risks
KLRS key risks include [1] a singular dependence on the clinical trial success of its lead product candidate, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -95%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -87%, 3Y Excs Rtn is -117%
3 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 14.58
4 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -46 Mil
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -39%
7 High stock price volatility
Vol 12M is 112%
8 Key risks
KLRS key risks include [1] a singular dependence on the clinical trial success of its lead product candidate, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

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Kalaris Therapeutics (KLRS) stock has lost about 25% since 12/31/2025 because of the following key factors:

1. Delayed Clinical Trial Progress and Manufacturing Challenges for TH103.

Kalaris Therapeutics announced in March 2026 that it had paused dosing patients in its Phase 1b/2 study for TH103 due to instances of ocular inflammation (IOI). While initial cases were attributed to host cell proteins in earlier manufacturing batches, a patient receiving a higher dose of the updated drug product in the Phase 1b/2 study still experienced moderate IOI. This necessitated further manufacturing refinements and a halt in dosing until new batches are available in the second quarter of 2026. Consequently, the anticipated preliminary data readout from the Phase 1b/2 study has been postponed from the second half of 2026 to the first half of 2027.

2. Persistent Net Losses and Increased Operating Expenses.

For the full year ended December 31, 2025, Kalaris Therapeutics reported a net loss of $43.4 million. This reflects ongoing operational expenses for the clinical-stage company, which currently generates no revenue. General and administrative expenses notably increased to $15.4 million in 2025 from $6.7 million in 2024, primarily due to costs associated with operating as a public company. While research and development (R&D) expenses decreased slightly to $30.8 million in 2025 from $45.0 million in 2024, the overall cash burn contributes to investor concern.

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Stock Movement Drivers

Fundamental Drivers

The -25.0% change in KLRS stock from 12/31/2025 to 4/22/2026 was primarily driven by a 0.0% change in the company's Shares Outstanding (Mil).
(LTM values as of)123120254222026Change
Stock Price ($)8.446.33-25.0%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)19190.0%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/22/2026
ReturnCorrelation
KLRS-25.0% 
Market (SPY)-5.4%19.5%
Sector (XLV)-5.4%6.3%

Fundamental Drivers

The 9.5% change in KLRS stock from 9/30/2025 to 4/22/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)93020254222026Change
Stock Price ($)5.786.339.5%
Change Contribution By: 
Total Revenues ($ Mil)00.0%
P/S Multiple0.0%
Shares Outstanding (Mil)119-92.8%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/22/2026
ReturnCorrelation
KLRS9.5% 
Market (SPY)-2.9%8.7%
Sector (XLV)5.6%4.7%

Fundamental Drivers

The -21.2% change in KLRS stock from 3/31/2025 to 4/22/2026 was primarily driven by a -92.8% change in the company's Shares Outstanding (Mil).
(LTM values as of)33120254222026Change
Stock Price ($)8.036.33-21.2%
Change Contribution By: 
Total Revenues ($ Mil)00.0%
P/S Multiple0.0%
Shares Outstanding (Mil)119-92.8%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2025 to 4/22/2026
ReturnCorrelation
KLRS-21.2% 
Market (SPY)16.3%13.5%
Sector (XLV)1.6%12.6%

Fundamental Drivers

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Market Drivers

3/31/2023 to 4/22/2026
ReturnCorrelation
KLRS  
Market (SPY)63.3%12.6%
Sector (XLV)18.4%12.9%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
KLRS Return-----26%-26%-45%
Peers Return-25%-32%4%39%59%13%34%
S&P 500 Return27%-19%24%23%16%3%88%

Monthly Win Rates [3]
KLRS Win Rate----50%75% 
Peers Win Rate52%42%52%45%55%40% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
KLRS Max Drawdown-----80%-37% 
Peers Max Drawdown-41%-47%-42%-35%-44%-30% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: REGN, APLS, OCUL, KOD, RGNX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/22/2026 (YTD)

How Low Can It Go

KLRS has limited trading history. Below is the Health Care sector ETF (XLV) in its place.

Unique KeyEventXLVS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-16.1%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven19.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven599 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-28.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven40.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven116 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-15.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven18.8%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven326 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-40.6%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven68.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven1,100 days1,480 days

Compare to REGN, APLS, OCUL, KOD, RGNX

In The Past

SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.

Preserve Wealth

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Asset Allocation

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About Kalaris Therapeutics (KLRS)

Allovir, Inc., a clinical-stage cell therapy company, engages in the research and development of allogeneic, off-the-shelf multi-virus specific T cell (VST) therapies to prevent and treat devastating viral-associated diseases. The company's lead product is posoleucel, an allogeneic, off-the-shelf VST therapy, to treat BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6, and JC virus. Its preclinical and clinical development product candidates include ALVR106 for the respiratory syncytial virus, influenza, parainfluenza virus, and human metapneumovirus; ALVR109 to treat SARS-CoV-2 and COVID-19; ALVR107 for treating hepatitis B; and ALVR108. The company was formerly known as ViraCyte, Inc. and changed its name to Allovir, Inc. in May 2019. Allovir, Inc. was founded in 2013 and is based in Waltham, Massachusetts.

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  • posoleucel: An allogeneic, off-the-shelf multi-virus specific T cell (VST) therapy designed to prevent and treat infections from BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus, human herpesvirus 6, and JC virus.
  • ALVR106: A product candidate under development for respiratory syncytial virus, influenza, parainfluenza virus, and human metapneumovirus.
  • ALVR109: A product candidate being developed to treat SARS-CoV-2 and COVID-19.
  • ALVR107: A product candidate in development for treating hepatitis B.
  • ALVR108: A preclinical and clinical development product candidate.

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Kalaris Therapeutics (symbol: KLRS), which is Allovir, Inc. as described in the background, is a clinical-stage cell therapy company. Its primary activities involve the research and development of allogeneic, off-the-shelf multi-virus specific T cell (VST) therapies, with lead product candidates such as posoleucel currently undergoing preclinical and clinical development.

As a clinical-stage biopharmaceutical company, Allovir, Inc. does not yet have commercial products approved for sale on the market. Therefore, the company does not have major customers in the traditional sense of selling its therapies to individuals (patients) or other companies (e.g., hospitals, clinics, or distributors).

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Andrew Oxtoby

President and Chief Executive Officer Andrew Oxtoby has served as the President and Chief Executive Officer of Kalaris Therapeutics since March 2024 for "Legacy Kalaris" and for the combined company following its merger. Prior to joining Kalaris, he was the Chief Commercial Officer of Chinook Therapeutics, a biotechnology company that was acquired by Novartis AG in 2023. He also served as the President and CEO of Aimmune Therapeutics, Inc., leading its integration into Nestlé Health Science after its acquisition, and was previously its Chief Commercial Officer before the acquisition. Earlier in his career, Mr. Oxtoby spent 16 years at Eli Lilly and Company, holding various leadership positions in the U.S. and Europe, including Vice President of U.S. Diabetes Connected Care & Insulins.

Matthew Gall

Chief Financial Officer and Treasurer Matthew Gall was appointed Chief Financial Officer and Treasurer of Kalaris Therapeutics, Inc., effective November 3, 2025. He previously held the position of Chief Financial Officer at iTeos Therapeutics from June 2020 to August 2025. Before his role at iTeos, Mr. Gall gained experience in senior corporate development and treasury roles at Sarepta Therapeutics from 2013 to 2020. He also held positions of increasing responsibility in finance and business development at Celgene Corporation and Gilead Sciences.

David L. Hallal

Executive Chairman of the Board David L. Hallal serves as the Executive Chairman of the Board for Kalaris Therapeutics. He is a co-founder of ElevateBio, where he previously served as Chairman and CEO. Mr. Hallal spent over a decade at Alexion Pharmaceuticals, holding roles as Chief Executive Officer, Chief Operating Officer, and Chief Commercial Officer, and was instrumental in growing the company from a pre-commercial stage to over $3 billion in annual revenues, including leading the successful launch of Soliris for ultra-rare diseases. His commercial leadership experience also includes positions at OSI Eyetech, where he launched Macugen, at Biogen, where he led the immunology sales team to launch Amevive, and various leadership roles at Amgen.

Brett R. Hagen

Chief Accounting Officer Brett R. Hagen has served as the Chief Accounting Officer of Kalaris Therapeutics, Inc. since 2025, and previously held the same role at AlloVir, Inc. His prior experience includes serving as Senior Director of Finance & Accounting at Eloxx Pharmaceuticals, Inc. in 2018. He was also Vice President of Finance at Boston Private Financial Holdings, Inc. from 2009 to 2014 and Controller at DNIB Unwind, Inc. from 2014 to 2016. Mr. Hagen also served as Chief Accounting Officer and Vice President of Finance at Proteostasis Therapeutics, Inc. in 2017.

Matthew Feinsod, M.D.

Chief Medical Officer Matthew Feinsod, M.D., is the Chief Medical Officer of Kalaris Therapeutics, a role he assumed upon the closing of the merger, having previously served as Chief Medical Officer for "Legacy Kalaris" since December 2024. Dr. Feinsod was formerly the Executive Vice President of Global Strategy and Development and interim Chief Medical Officer at Applied Genetic Technologies Corp. (AGTC), a clinical-stage biotechnology company that was acquired by Syncona Limited. He co-founded and led Imagen Biotech, Inc., a venture-backed company focused on developing ophthalmology treatments. Dr. Feinsod has also held positions as Senior Vice President of Strategy and Product Development at Eyetech Pharmaceuticals, Inc. and as a medical officer in the ophthalmology division of the U.S. Food and Drug Administration.

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Key Risks to Kalaris Therapeutics (KLRS)

Kalaris Therapeutics (KLRS) is a clinical-stage biopharmaceutical company focused on developing and commercializing therapeutics for prevalent retinal diseases, with its lead investigational therapy being TH103. As such, the company faces several significant risks inherent to the biotechnology industry.

  1. Clinical Trial Failures and Regulatory Approval Risk: As a clinical-stage company, the most significant risk to Kalaris Therapeutics is the potential for its lead product candidate, TH103, to fail in ongoing or future clinical trials, or to not receive regulatory approval. Clinical drug development is a lengthy, expensive, and uncertain process, with no guarantee that TH103 will prove safe and effective in later stages of development. For example, the Phase 1a clinical study data identified two cases of intraocular inflammation, which require close monitoring in subsequent data releases. Any setbacks in clinical trials or delays in obtaining necessary regulatory approvals would substantially harm the business and its prospects.
  2. Intense Market Competition: The market for anti-VEGF retinal therapies, which TH103 targets, is highly competitive and dominated by established pharmaceutical companies such as Regeneron (Eylea) and Roche (Lucentis/Vabysmo). Kalaris Therapeutics aims to differentiate TH103 through potentially longer-lasting and increased anti-VEGF activity. However, even with positive clinical data, gaining significant market share against entrenched competitors with strong commercial infrastructures and existing products will be challenging. The emergence of biosimilars and other next-generation therapies further intensifies this competitive landscape.
  3. Financial Sustainability and Need for Additional Capital: Kalaris Therapeutics is a pre-revenue company that has incurred significant net losses since its inception. While the company has reported a cash runway into 2027 based on its financial reports as of late 2025, clinical trials are capital-intensive, and operational spending is expected to increase as TH103 advances through development. The company will require substantial additional funding to complete the development, obtain regulatory approval, and successfully commercialize TH103. Any delays in development or commercialization could exhaust current financial resources faster than anticipated, necessitating further capital raising activities that may dilute existing shareholders.

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Kalaris Therapeutics (NASDAQ: KLRS) is a clinical-stage ophthalmology biotechnology company focused on developing therapies for neovascular retinal diseases. Its lead product candidate, TH103, is being developed to treat several conditions. The addressable markets for Kalaris Therapeutics' main products or services are as follows:

Neovascular Age-Related Macular Degeneration (nAMD)

The global market for neovascular age-related macular degeneration (nAMD) treatment is valued at approximately USD 3.3 billion in 2025 and is projected to grow to USD 5.38 billion by 2035. In the United States, the market for treating neovascular age-related macular degeneration is projected to grow at a Compound Annual Growth Rate (CAGR) of 5.6% from 2025 to 2035.

Diabetic Macular Edema (DME)

The global diabetic macular edema (DME) market size reached approximately USD 5.4 billion in 2023 and is expected to grow to USD 7.5 billion by 2034. For the U.S. specifically, the DME market was estimated at approximately USD 1.3 billion in 2023.

Retinal Vein Occlusion (RVO)

The global retinal vein occlusion (RVO) treatment market size was estimated at approximately USD 2.48 billion in 2022 and is projected to reach USD 4.18 billion by 2030. In the United States, the RVO market was approximately USD 1.61 billion in 2022.

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Share Issuance

  • In March 2025, as a result of the merger with AlloVir, pre-merger Kalaris stockholders received approximately 74.47% and pre-merger AlloVir stockholders received approximately 25.53% of the combined company's outstanding common stock on a fully-diluted basis.
  • Kalaris Therapeutics announced an oversubscribed private placement in December 2025 to raise approximately $50.0 million gross, which included the issuance of 4,200,000 common shares and 800,000 pre-funded warrants.

Inbound Investments

  • Upon the completion of the merger in March 2025, the combined company, Kalaris Therapeutics, had approximately $100 million in cash.
  • In December 2025, Kalaris Therapeutics received approximately $50.0 million gross from an oversubscribed private placement.

Capital Expenditures

  • The approximately $100 million in cash obtained from the merger in March 2025 is expected to fund the combined company's operating expenses and capital expenditure requirements into the fourth quarter of 2026.
  • As of September 30, 2025, Kalaris had $77.0 million in cash, cash equivalents, and short-term investments, which is expected to fund operations into 2027.
  • The company's activities are primarily focused on research and development, with substantially all operating expenses related to R&D activities and general corporate functions, often carried out through third-party contractors.

Latest Trefis Analyses

TitleDate
0DASHBOARDS 
1Kalaris Therapeutics Earnings Notes12/16/2025
Title
0ARTICLES

Trade Ideas

Select ideas related to KLRS.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
0.0%0.0%0.0%
CNC_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026CNCCenteneDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

KLRSREGNAPLSOCULKODRGNXMedian
NameKalaris .Regenero.Apellis .Ocular T.Kodiak S.Regenxbio 
Mkt Price6.33746.5840.899.6645.199.3425.27
Mkt Cap0.177.05.22.22.50.52.3
Rev LTM014,3431,004520170111
Op Inc LTM-463,70255-270-234-161-104
FCF LTM-383,76545-217-137-126-82
FCF 3Y Avg-3,657-213-143-150-177-150
CFO LTM-384,97945-205-136-124-81
CFO 3Y Avg-4,664-212-137-136-172-137

Growth & Margins

KLRSREGNAPLSOCULKODRGNXMedian
NameKalaris .Regenero.Apellis .Ocular T.Kodiak S.Regenxbio 
Rev Chg LTM-1.0%28.5%-18.5%-104.5%14.7%
Rev Chg 3Y Avg-5.7%183.8%1.4%-25.6%15.7%
Rev Chg Q-2.5%-5.9%-22.4%-43.0%-1.7%
QoQ Delta Rev Chg LTM-0.7%-1.2%-6.9%-5.7%-0.3%
Op Inc Chg LTM10.8%-9.5%133.6%-57.2%-25.4%30.3%0.6%
Op Inc Chg 3Y Avg--9.4%71.6%-56.8%8.6%14.0%8.6%
Op Mgn LTM-25.8%5.5%-519.8%--94.6%-44.5%
Op Mgn 3Y Avg-29.0%-48.7%-310.1%--223.1%-135.9%
QoQ Delta Op Mgn LTM--0.9%-2.4%-70.1%-1.5%-1.7%
CFO/Rev LTM-34.7%4.5%-394.4%--72.7%-34.1%
CFO/Rev 3Y Avg-33.6%-52.2%-242.0%--174.2%-113.2%
FCF/Rev LTM-26.3%4.5%-417.5%--74.1%-34.8%
FCF/Rev 3Y Avg-26.4%-52.3%-253.8%--179.3%-115.8%

Valuation

KLRSREGNAPLSOCULKODRGNXMedian
NameKalaris .Regenero.Apellis .Ocular T.Kodiak S.Regenxbio 
Mkt Cap0.177.05.22.22.50.52.3
P/S-5.45.241.4-2.85.3
P/Op Inc-2.720.893.4-8.0-10.5-3.0-2.8
P/EBIT-2.914.675.7-8.5-10.7-3.2-3.1
P/E-2.817.1231.3-8.1-10.7-2.5-2.7
P/CFO-3.215.5114.3-10.5-18.1-3.9-3.6
Total Yield-35.3%6.3%0.4%-12.4%-9.3%-40.1%-10.8%
Dividend Yield0.0%0.5%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-4.4%-3.0%-12.6%-52.4%-30.2%-12.6%
D/E0.00.00.10.00.00.20.0
Net D/E-0.9-0.10.0-0.3-0.1-0.3-0.2

Returns

KLRSREGNAPLSOCULKODRGNXMedian
NameKalaris .Regenero.Apellis .Ocular T.Kodiak S.Regenxbio 
1M Rtn-2.6%1.4%132.7%19.3%103.2%12.0%15.6%
3M Rtn-35.3%-0.2%95.2%-15.4%69.2%-37.8%-7.8%
6M Rtn44.5%28.0%45.3%-14.8%150.4%-23.4%36.3%
12M Rtn-6.4%28.2%135.4%22.1%1,141.5%19.4%25.2%
3Y Rtn-44.8%-6.1%-52.6%50.2%777.5%-51.0%-25.5%
1M Excs Rtn-11.1%-7.1%124.3%10.8%94.7%3.5%7.2%
3M Excs Rtn-39.2%-4.1%91.4%-19.2%65.4%-41.6%-11.6%
6M Excs Rtn23.2%23.8%45.1%-26.7%149.3%-32.1%23.5%
12M Excs Rtn-42.6%-4.7%88.4%-11.4%1,252.1%1.7%-1.5%
3Y Excs Rtn-116.8%-80.3%-122.1%-5.4%744.7%-123.7%-98.5%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024
Business of developing retinal therapies 0
Total 0


Assets by Segment
$ Mil20252024
Business of developing retinal therapies64
Total64


Price Behavior

Price Behavior
Market Price$6.33 
Market Cap ($ Bil)0.1 
First Trading Date07/30/2020 
Distance from 52W High-42.3% 
   50 Days200 Days
DMA Price$8.93$7.54
DMA Trendupdown
Distance from DMA-29.1%-16.0%
 3M1YR
Volatility94.4%112.6%
Downside Capture1.120.88
Upside Capture40.25128.39
Correlation (SPY)20.5%7.7%
KLRS Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta1.571.731.500.760.790.38
Up Beta2.31-0.101.84-1.100.32-0.59
Down Beta-0.311.971.53-0.210.730.71
Up Capture-135%63%31%186%108%8%
Bmk +ve Days7162765139424
Stock +ve Days5132254110111
Down Capture402%251%200%154%137%86%
Bmk -ve Days12233358110323
Stock -ve Days17294070136142

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KLRS
KLRS-6.1%112.7%0.45-
Sector ETF (XLV)12.0%15.9%0.529.8%
Equity (SPY)26.7%12.5%1.778.0%
Gold (GLD)38.9%27.4%1.1913.3%
Commodities (DBC)23.5%16.2%1.323.1%
Real Estate (VNQ)15.6%13.6%0.828.5%
Bitcoin (BTCUSD)-12.8%42.6%-0.215.3%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KLRS
KLRS-11.6%111.4%-0.01-
Sector ETF (XLV)5.6%14.6%0.2012.9%
Equity (SPY)10.5%17.1%0.4812.7%
Gold (GLD)21.5%17.8%0.9913.5%
Commodities (DBC)10.7%18.8%0.477.5%
Real Estate (VNQ)3.6%18.8%0.0913.3%
Bitcoin (BTCUSD)3.8%56.4%0.296.5%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KLRS
KLRS-6.0%111.4%-0.01-
Sector ETF (XLV)9.5%16.5%0.4612.9%
Equity (SPY)13.8%17.9%0.6612.7%
Gold (GLD)13.9%15.9%0.7313.5%
Commodities (DBC)8.1%17.6%0.387.5%
Real Estate (VNQ)5.4%20.7%0.2313.3%
Bitcoin (BTCUSD)68.1%66.9%1.076.5%

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Short Interest

Short Interest: As Of Date3312026
Short Interest: Shares Quantity1.0 Mil
Short Interest: % Change Since 31520268.2%
Average Daily Volume0.1 Mil
Days-to-Cover Short Interest14.6 days
Basic Shares Quantity19.5 Mil
Short % of Basic Shares5.1%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/17/2026-3.3%-26.2%-33.4%
11/12/2025-2.2%27.2%75.0%
8/13/2025-8.4%3.2%71.9%
SUMMARY STATS   
# Positive022
# Negative311
Median Positive 15.2%73.4%
Median Negative-3.3%-26.2%-33.4%
Max Positive 27.2%75.0%
Max Negative-8.4%-26.2%-33.4%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/17/202610-K
09/30/202511/12/202510-Q
06/30/202508/13/202510-Q
03/31/202505/14/202510-Q
09/30/202412/09/2024S-4

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 3/17/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2027 Cash Runway 2,028    

Prior: Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2027 Cash Runway