Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Low stock price volatility
Vol 12M is 45%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.

Trading close to highs
Dist 52W High is 0.0%, Dist 3Y High is -0.2%

Weak multi-year price returns
2Y Excs Rtn is -9.3%, 3Y Excs Rtn is -48%

Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 97x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 135x

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 14%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 74%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -4.5%

Key risks
FOLD key risks include [1] heavy reliance on its key therapy Galafold and a limited pipeline, Show more.

0 Low stock price volatility
Vol 12M is 45%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
2 Trading close to highs
Dist 52W High is 0.0%, Dist 3Y High is -0.2%
3 Weak multi-year price returns
2Y Excs Rtn is -9.3%, 3Y Excs Rtn is -48%
4 Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 97x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 135x
5 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 14%
6 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 74%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -4.5%
8 Key risks
FOLD key risks include [1] heavy reliance on its key therapy Galafold and a limited pipeline, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Amicus Therapeutics (FOLD) stock has remained largely at the same level since 12/31/2025 because of the following key factors:

1. Proposed Acquisition by BioMarin Pharmaceutical created a price ceiling.

In December 2025, BioMarin Pharmaceutical entered a definitive agreement to acquire Amicus Therapeutics for $14.50 per share in cash, totaling $4.8 billion. This proposed acquisition, expected to close in the second quarter of 2026, has effectively capped Amicus's stock price, as the market has largely factored in this offer, leading to the stock trading consistently near the acquisition price.

2. Mixed Q4 2025 earnings report balanced investor sentiment.

Amicus Therapeutics reported Q4 2025 earnings on February 20, 2026, which presented a mixed financial picture. The company missed analysts' consensus earnings per share (EPS) estimate by $0.03, reporting an adjusted EPS of $0.10 against an expectation of $0.13. Conversely, quarterly revenue exceeded estimates, rising 23.7% year-over-year to $185.21 million, surpassing analyst projections of $180 million to $185 million. This combination of an EPS miss and a revenue beat likely contributed to a balanced market reaction, preventing significant price swings.

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Stock Movement Drivers

Fundamental Drivers

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Market Drivers

12/31/2025 to 4/27/2026
ReturnCorrelation
FOLD1.8% 
Market (SPY)4.2%-0.1%
Sector (XLV)-7.3%30.6%

Fundamental Drivers

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Market Drivers

9/30/2025 to 4/27/2026
ReturnCorrelation
FOLD83.9% 
Market (SPY)7.0%12.6%
Sector (XLV)3.5%12.4%

Fundamental Drivers

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Market Drivers

3/31/2025 to 4/27/2026
ReturnCorrelation
FOLD77.6% 
Market (SPY)28.1%24.1%
Sector (XLV)-0.4%37.2%

Fundamental Drivers

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Market Drivers

3/31/2023 to 4/27/2026
ReturnCorrelation
FOLD30.7% 
Market (SPY)79.8%26.9%
Sector (XLV)16.0%32.6%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
FOLD Return-50%6%16%-34%51%2%-37%
Peers Return2%29%2%-1%-0%-9%21%
S&P 500 Return27%-19%24%23%16%5%91%

Monthly Win Rates [3]
FOLD Win Rate42%50%58%42%58%100% 
Peers Win Rate52%65%52%47%55%25% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
FOLD Max Drawdown-62%-46%-18%-36%-40%0% 
Peers Max Drawdown-23%-18%-24%-17%-32%-14% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: BMRN, SRPT, VRTX, REGN, ALNY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/27/2026 (YTD)

How Low Can It Go

Unique KeyEventFOLDS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-73.9%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven283.0%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-40.6%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven68.3%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven36 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-56.3%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven128.9%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven373 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-81.4%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven436.9%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven2,074 days1,480 days

Compare to BMRN, SRPT, VRTX, REGN, ALNY

In The Past

Amicus Therapeutics's stock fell -73.9% during the 2022 Inflation Shock from a high on 1/7/2021. A -73.9% loss requires a 283.0% gain to breakeven.

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Asset Allocation

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About Amicus Therapeutics (FOLD)

Amicus Therapeutics, Inc., a biotechnology company, focuses on discovering, developing, and delivering medicines for rare diseases. Its commercial product and product candidates include Galafold, an oral precision medicine for the treatment of adults with a confirmed diagnosis of Fabry disease and an amenable galactosidase alpha gene variant based on in vitro assay data. It also develops AT-GAA, a novel treatment paradigm for Pompe disease; enzyme replacement therapies for Pompe diseases; CLN3, which is in Phase 1/2 clinical study to evaluate the safety and efficacy of a single intrathecal administration of an AAV serotype AT-GTX-502 gene therapy in patients with CLN3; and CDKL5, a gene on the X-chromosome encoding the CDKL5 protein that regulates the expression of essential proteins for normal brain development. The company has collaboration and license agreements with Nationwide Children's Hospital; University of Pennsylvania; and GlaxoSmithKline. Amicus Therapeutics, Inc. was incorporated in 2002 and is headquartered in Philadelphia, Pennsylvania.

AI Analysis | Feedback

Here are 1-3 brief analogies for Amicus Therapeutics (FOLD):

  • Like BioMarin Pharmaceutical (BMRN) but focused on a different set of rare genetic diseases.
  • Similar to Ultragenyx Pharmaceutical (RARE), developing treatments for specific rare genetic conditions.
  • A specialized biotech company akin to Sarepta Therapeutics (SRPT), but targeting different rare genetic disorders.

AI Analysis | Feedback

  • Galafold: An oral precision medicine for the treatment of adults with Fabry disease.
  • AT-GAA: A novel treatment paradigm for Pompe disease.
  • CLN3 (AT-GTX-502): A gene therapy in clinical study for CLN3 disease.
  • CDKL5: A gene therapy candidate for CDKL5 deficiency disorder.

AI Analysis | Feedback

Amicus Therapeutics (symbol: FOLD) is a biotechnology company that develops and delivers medicines for rare diseases. Based on the nature of its products (prescription medicines like Galafold for Fabry disease), Amicus Therapeutics primarily sells its products to other companies and organizations within the healthcare system, rather than directly to individual patients.

The major categories of customers for Amicus Therapeutics include:

  1. Pharmaceutical Wholesalers and Distributors: These companies purchase medicines in bulk from manufacturers like Amicus Therapeutics and then distribute them to pharmacies, hospitals, and other healthcare providers.
  2. Hospitals and Clinics: Healthcare institutions, including specialized rare disease centers, that purchase and administer Amicus Therapeutics' medicines to their patients.
  3. Specialty Pharmacies: Pharmacies that specialize in dispensing complex, high-cost, or rare disease medications, often providing additional support services to patients and healthcare providers.

AI Analysis | Feedback

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  • Lonza Group AG (LONS.SW)
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  • Nationwide Children's Hospital
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Bradley L. Campbell, President and Chief Executive Officer

Bradley L. Campbell became the Chief Executive Officer of Amicus Therapeutics in 2022, having joined the company in 2006. He previously served as Chief Operating Officer and led the global commercialization of Galafold, Amicus's first approved medicine. Prior to his tenure at Amicus, he gained experience in commercial and business development roles at Genzyme and Bristol-Myers Squibb, and as a strategy consultant for Marakon Associates, bringing over 20 years of experience in the orphan drug industry. Mr. Campbell also served on the board of Progenics Pharmaceuticals from 2016 until its acquisition by Lantheus Holdings in 2020.

Simon Harford, Chief Financial Officer

Simon Harford serves as the Chief Financial Officer for Amicus Therapeutics.

David Clark, Chief People Officer

David Clark holds the position of Chief People Officer at Amicus Therapeutics.

Jeffrey P. Castelli, PhD, Chief Development Officer

Jeffrey P. Castelli, PhD, is the Chief Development Officer for Amicus Therapeutics. In 2019, he was also mentioned as Chief Portfolio Officer and Head of Gene Therapy.

Ellen S. Rosenberg, Chief Legal Officer, General Counsel and Corporate Secretary

Ellen S. Rosenberg is the Chief Legal Officer, General Counsel, and Corporate Secretary at Amicus Therapeutics.

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Key Risks to Amicus Therapeutics (FOLD)

Amicus Therapeutics (FOLD), a biotechnology company specializing in medicines for rare diseases, faces several key risks inherent to the pharmaceutical and biotechnology industry, particularly concerning its commercial products and pipeline development.

  1. Risk of Acquisition by BioMarin and its Implications: The proposed $4.7 billion acquisition by BioMarin Pharmaceutical represents a significant and immediate risk to the existing structure and future trajectory of Amicus Therapeutics. While the acquisition may offer a premium to shareholders, it introduces substantial integration risks, potential rationalization of Amicus's standalone pipeline, and a dilution of its unique identity within a larger corporate entity. Should the acquisition not proceed, Amicus would then continue to navigate its business as an independent entity, facing the other inherent risks more directly.
  2. Competition and Patent Risk for Commercial Products: Amicus Therapeutics is heavily reliant on its commercial products, primarily Galafold for Fabry disease and its treatments for Pompe disease, for revenue generation. The company faces ongoing patent litigation for Galafold, including a notable challenge from Aurobindo and an expected decision by mid-2026 on a Teva patent challenge, which could impact its market exclusivity. Furthermore, Amicus confronts significant competition from established pharmaceutical and biotechnology companies such as Takeda, Sanofi, and Chiesi in the Fabry and Pompe disease markets. The potential emergence of newer therapeutic approaches, including advanced gene editing and biologics, could also challenge the market position of Amicus's current small-molecule drugs and potentially curative gene therapies, thereby reducing demand for chronic treatments.
  3. Clinical Development and Regulatory Approval Risk for Pipeline Products: A critical risk for Amicus Therapeutics is the successful clinical development and regulatory approval of its pipeline candidates, such as DMX-200 for FSGS and its gene therapy programs. There is no guarantee that ongoing or future clinical trials will demonstrate sufficient efficacy and safety to meet regulatory requirements, or that regulatory bodies will grant market approval even if trial outcomes are positive. Delays or setbacks in clinical trials, manufacturing inspections, or the regulatory review process, as previously experienced with AT-GAA, could significantly impede the company's growth prospects and negatively impact its valuation.

AI Analysis | Feedback

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AI Analysis | Feedback

For Amicus Therapeutics (symbol: FOLD), the addressable markets for their main products or services are as follows:

  • Galafold (Fabry disease): The global Fabry disease treatment market size is valued at approximately USD 2.45 billion in 2025 and is projected to increase to about USD 5.20 billion by 2035.
  • AT-GAA (Pompe disease): The global Pompe Disease Treatment Market size was valued at USD 2.24 billion in 2024 and is poised to grow from USD 2.4 billion in 2025 to USD 4.09 billion by 2033.
  • CLN3 (Batten disease): null
  • CDKL5: The global market for CDKL5 Deficiency Disorder (CDD) was valued at US$107.2 million in 2024 and is projected to reach US$130.3 million by 2030.

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Expected Revenue Growth Drivers for Amicus Therapeutics (FOLD)

Over the next two to three years, Amicus Therapeutics (FOLD) anticipates several key drivers for its revenue growth:

  1. Continued Expansion of Galafold (migalastat) for Fabry Disease: Growth is expected from robust new patient starts, sustained commercial execution in existing markets, and expansion into additional geographies. Amicus Therapeutics projected Galafold revenue growth of 10-15% at constant exchange rates (CER) for the full year 2025.
  2. Accelerated Adoption and Geographic Rollout of Pombiliti + Opfolda (cipaglucosidase alfa + miglustat) for Pompe Disease: This two-component therapy, a relatively recent launch for late-onset Pompe disease, is demonstrating strong momentum. Future revenue is expected from high commercial demand and continued expansion into new launch countries. The company guided for Pombiliti and Opfolda revenue growth of 50-65% at CER for 2025.
  3. Advancement of Pipeline Asset DMX-200 for Focal Segmental Glomerulosclerosis (FSGS): Although commercialization may extend beyond the immediate two-to-three-year window, the progression of DMX-200, currently in a Phase 3 clinical study, is a significant long-term driver of potential revenue. This asset targets a rare kidney disease with no approved therapies, representing a substantial unmet medical need and future market opportunity.

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Inbound Investments

  • BioMarin Pharmaceutical entered into a definitive agreement in December 2025 to acquire Amicus Therapeutics for approximately $4.8 billion in an all-cash transaction.
  • The acquisition valued Amicus Therapeutics at $14.50 per share.
  • This acquisition is expected to close in the second quarter of 2026.

Outbound Investments

  • Amicus Therapeutics made a $30 million upfront payment for the DMX-200 licensing deal in the first quarter of 2025.
  • The company made a recent acquisition of a European biotechnology firm in December 2025.
  • Amicus is strategically investing in its pipeline of gene therapies for conditions like Pompe disease and other rare metabolic disorders.

Capital Expenditures

  • Capital expenditures for Amicus Therapeutics were -$3.30 million in the last 12 months as of December 31, 2025.

Better Bets vs. Amicus Therapeutics (FOLD)

Trade Ideas

Select ideas related to FOLD.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
0.0%0.0%0.0%
CNC_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026CNCCenteneDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

FOLDBMRNSRPTVRTXREGNALNYMedian
NameAmicus T.BioMarin.Sarepta .Vertex P.Regenero.Alnylam . 
Mkt Price14.4953.8020.98426.01744.44308.51181.16
Mkt Cap4.510.32.2108.076.840.825.6
Rev LTM6343,2212,19812,00114,3433,7143,468
Op Inc LTM34409-6584,5543,702502456
FCF LTM30717-3153,1943,765465591
FCF 3Y Avg-28415-4191,8323,657155285
CFO LTM33828-2053,6314,979524676
CFO 3Y Avg-23520-3042,2254,664207363

Growth & Margins

FOLDBMRNSRPTVRTXREGNALNYMedian
NameAmicus T.BioMarin.Sarepta .Vertex P.Regenero.Alnylam . 
Rev Chg LTM20.0%12.9%15.6%8.9%1.0%65.2%14.2%
Rev Chg 3Y Avg24.5%15.4%33.9%10.4%5.7%54.8%20.0%
Rev Chg Q23.7%17.0%-32.7%9.5%2.5%84.9%13.3%
QoQ Delta Rev Chg LTM5.9%4.1%-8.9%2.4%0.7%15.7%3.2%
Op Inc Chg LTM1.3%-13.7%-401.6%2,051.3%-9.5%383.6%-4.1%
Op Inc Chg 3Y Avg70.6%130.7%-56.7%644.7%-9.4%161.6%100.6%
Op Mgn LTM5.4%12.7%-29.9%37.9%25.8%13.5%13.1%
Op Mgn 3Y Avg-2.2%12.9%-13.3%24.7%29.0%-3.3%5.4%
QoQ Delta Op Mgn LTM-0.3%-7.2%-26.4%38.7%-0.9%5.3%-0.6%
CFO/Rev LTM5.2%25.7%-9.3%30.3%34.7%14.1%19.9%
CFO/Rev 3Y Avg-6.2%17.5%-20.2%20.5%33.6%6.5%12.0%
FCF/Rev LTM4.7%22.3%-14.3%26.6%26.3%12.5%17.4%
FCF/Rev 3Y Avg-7.2%13.7%-26.7%17.0%26.4%4.3%9.0%

Valuation

FOLDBMRNSRPTVRTXREGNALNYMedian
NameAmicus T.BioMarin.Sarepta .Vertex P.Regenero.Alnylam . 
Mkt Cap4.510.32.2108.076.840.825.6
P/S7.13.21.09.05.411.06.2
P/Op Inc129.825.3-3.323.720.781.324.5
P/EBIT96.621.0-3.323.214.670.922.1
P/E-165.229.6-3.127.317.0130.022.2
P/CFO135.112.5-10.729.815.477.822.6
Total Yield-0.6%3.4%-32.4%3.7%6.4%0.8%2.1%
Dividend Yield0.0%0.0%0.0%0.0%0.5%0.0%0.0%
FCF Yield 3Y Avg-0.8%3.5%-7.6%1.7%4.4%0.3%1.0%
D/E0.10.10.50.00.00.00.0
Net D/E0.0-0.10.0-0.0-0.1-0.0-0.0

Returns

FOLDBMRNSRPTVRTXREGNALNYMedian
NameAmicus T.BioMarin.Sarepta .Vertex P.Regenero.Alnylam . 
1M Rtn0.6%-0.6%5.1%-1.6%0.9%-2.8%-0.0%
3M Rtn1.4%-5.2%-8.0%-10.7%-2.3%-14.6%-6.6%
6M Rtn63.2%2.2%-10.7%1.4%27.5%-35.5%1.8%
12M Rtn97.1%-15.0%-65.3%-13.7%24.2%22.6%4.5%
3Y Rtn25.6%-44.0%-82.9%25.0%-6.5%54.9%9.3%
1M Excs Rtn-10.3%-13.9%-14.0%-16.9%-12.4%-16.7%-13.9%
3M Excs Rtn-1.8%-8.5%-11.2%-13.9%-5.5%-17.8%-9.8%
6M Excs Rtn64.0%-7.8%-10.6%-5.7%23.2%-40.0%-6.7%
12M Excs Rtn70.5%-45.0%-96.8%-44.3%-6.0%-3.6%-25.1%
3Y Excs Rtn-47.7%-118.1%-157.1%-44.3%-79.8%-21.6%-63.8%

Comparison Analyses

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FDA Approved Drugs Data

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Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
BLA761204  POMBILITIcipaglucosidase alfa-atgainjectable928202322.4%-0.7%-9.7%-30.5%22.2%
NDA215211  OPFOLDAmiglustatcapsule928202322.4%-0.7%-9.7%-30.5%22.2%
NDA208623  GALAFOLDmigalastat hydrochloridecapsule8102018-31.0%-25.7%-29.5%0.4%-5.6%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Galafold ® sales458388329  
Pombiliti ® + Opfolda ® sales70120  
Net product sales   306261
Total528399329306261


Price Behavior

Price Behavior
Market Price$14.49 
Market Cap ($ Bil)4.5 
First Trading Date05/31/2007 
Distance from 52W High0.0% 
   50 Days200 Days
DMA Price$14.40$10.84
DMA Trendupindeterminate
Distance from DMA0.6%33.7%
 3M1YR
Volatility1.7%45.8%
Downside Capture-0.030.24
Upside Capture1.76109.06
Correlation (SPY)1.3%17.2%
FOLD Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta-0.02-0.02-0.010.590.630.78
Up Beta0.050.080.121.250.430.57
Down Beta-0.07-0.05-0.010.010.600.60
Up Capture3%1%-1%174%113%93%
Bmk +ve Days7162765139424
Stock +ve Days8172559122367
Down Capture-3%-6%-7%-10%71%102%
Bmk -ve Days12233358110323
Stock -ve Days7142246106355

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FOLD
FOLD98.5%45.7%1.63-
Sector ETF (XLV)5.9%15.8%0.1731.9%
Equity (SPY)31.2%12.5%1.9117.1%
Gold (GLD)39.7%27.2%1.210.2%
Commodities (DBC)45.1%18.1%1.93-3.4%
Real Estate (VNQ)13.1%13.4%0.6711.7%
Bitcoin (BTCUSD)-17.7%42.1%-0.358.2%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FOLD
FOLD7.8%46.9%0.32-
Sector ETF (XLV)4.9%14.6%0.1632.7%
Equity (SPY)12.9%17.1%0.5934.5%
Gold (GLD)20.9%17.8%0.965.8%
Commodities (DBC)14.5%19.1%0.623.3%
Real Estate (VNQ)3.4%18.8%0.0832.1%
Bitcoin (BTCUSD)6.5%56.3%0.3316.5%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with FOLD
FOLD6.1%55.4%0.33-
Sector ETF (XLV)9.1%16.5%0.4540.8%
Equity (SPY)14.8%17.9%0.7140.4%
Gold (GLD)13.8%15.9%0.722.9%
Commodities (DBC)10.0%17.8%0.4712.7%
Real Estate (VNQ)5.3%20.7%0.2229.4%
Bitcoin (BTCUSD)68.2%66.9%1.0713.0%

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Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity21.9 Mil
Short Interest: % Change Since 33120263.9%
Average Daily Volume2.9 Mil
Days-to-Cover Short Interest7.5 days
Basic Shares Quantity309.0 Mil
Short % of Basic Shares7.1%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
2/20/20260.1%0.2%0.6%
11/4/20251.5%1.6%12.3%
7/31/2025-2.3%13.1%24.8%
5/1/2025-13.0%-20.7%-21.0%
2/19/2025-2.9%-7.5%-6.6%
11/6/2024-4.3%-10.6%-16.9%
8/8/202413.2%15.0%16.5%
5/9/2024-6.5%-4.7%-0.9%
...
SUMMARY STATS   
# Positive101113
# Negative131210
Median Positive2.8%8.6%12.3%
Median Negative-4.0%-7.8%-13.4%
Max Positive13.2%22.8%34.4%
Max Negative-13.0%-20.7%-25.1%

SEC Filings

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Report DateFiling DateFiling
12/31/202502/20/202610-K
09/30/202511/04/202510-Q
06/30/202507/31/202510-Q
03/31/202505/01/202510-Q
12/31/202402/19/202510-K
09/30/202411/06/202410-Q
06/30/202408/08/202410-Q
03/31/202405/09/202410-Q
12/31/202302/28/202410-K
09/30/202311/08/202310-Q
06/30/202308/08/202310-Q
03/31/202305/10/202310-Q
12/31/202203/01/202310-K
09/30/202211/07/202210-Q
06/30/202208/04/202210-Q
03/31/202205/10/202210-Q

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Campbell, Bradley LPresident and CEODirectSell304202614.3522,500322,83914,329,460Form
2Campbell, Bradley LPresident and CEODirectSell122202614.3175,0001,073,18214,612,167Form
3Clark, David MichaelChief People OfficerDirectSell1223202514.1725,642363,3803,481,747Form
4Campbell, Bradley LPresident and CEODirectSell1217202510.8677,926846,01112,265,591Form
5Clark, David MichaelChief People OfficerDirectSell1217202511.0025,643282,0732,984,652Form