Aclaris Therapeutics (ACRS)
Market Price (5/22/2026): $4.59 | Market Cap: $591.2 MilSector: Health Care | Industry: Biotechnology
Aclaris Therapeutics (ACRS)
Market Price (5/22/2026): $4.59Market Cap: $591.2 MilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -18% Megatrend and thematic driversMegatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. | Weak multi-year price returns3Y Excs Rtn is -126% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -78 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -938% Stock price has recently run up significantly12M Rtn12 month market price return is 252% Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -53%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -32% Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 144% Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -624%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -625% Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -16% Key risksACRS key risks include [1] uncertainty in clinical trial outcomes and regulatory approvals, Show more. |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -18% |
| Megatrend and thematic driversMegatrends include Precision Medicine, and Biotechnology & Genomics. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. |
| Weak multi-year price returns3Y Excs Rtn is -126% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -78 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -938% |
| Stock price has recently run up significantly12M Rtn12 month market price return is 252% |
| Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -53%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -32% |
| Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 144% |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -624%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -625% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -16% |
| Key risksACRS key risks include [1] uncertainty in clinical trial outcomes and regulatory approvals, Show more. |
Qualitative Assessment
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1. Positive Clinical Trial Advancements for Key Product Candidates.
Aclaris Therapeutics announced positive interim results from its Phase 1a trial of ATI-052, an anti-TSLP/IL-4Rα bispecific antibody, on January 6, 2026, indicating a favorable safety profile and supporting expedited clinical development into Phase 1b trials for atopic dermatitis and asthma in the first quarter of 2026. Further positive full top-line Phase 1a results for ATI-052 were released on April 28, 2026, which suggested a prolonged half-life of approximately 45 days, potentially enabling extended dosing intervals of up to three months. Additionally, the company presented positive results from its Phase 2a trial of ATI-2138, an oral ITK/JAK3 inhibitor, on March 20, 2026. On April 28, 2026, Aclaris designated lichen planus as the primary indication for ATI-2138, targeting a potential U.S. market estimated to be between $1.0 billion and $4.0 billion.
2. Strengthened Financial Position and Extended Cash Runway.
In March 2026, Aclaris Therapeutics successfully raised $59.8 million in gross proceeds through the sale of 18.4 million shares of its common stock. This financing bolstered the company's cash reserves, with cash, cash equivalents, and marketable securities increasing to $190.8 million as of March 31, 2026, up from $151.4 million at the end of December 2025. This improved financial standing is projected by the company to fund its operations through the end of 2028.
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Stock Movement Drivers
Fundamental Drivers
The 29.3% change in ACRS stock from 1/31/2026 to 5/21/2026 was primarily driven by a 155.6% change in the company's P/S Multiple.| (LTM values as of) | 1312026 | 5212026 | Change |
|---|---|---|---|
| Stock Price ($) | 3.51 | 4.54 | 29.3% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 16 | 8 | -46.8% |
| P/S Multiple | 27.3 | 69.9 | 155.6% |
| Shares Outstanding (Mil) | 123 | 129 | -4.8% |
| Cumulative Contribution | 29.3% |
Market Drivers
1/31/2026 to 5/21/2026| Return | Correlation | |
|---|---|---|
| ACRS | 29.3% | |
| Market (SPY) | 7.6% | 41.5% |
| Sector (XLV) | -3.9% | 20.8% |
Fundamental Drivers
The 80.2% change in ACRS stock from 10/31/2025 to 5/21/2026 was primarily driven by a 279.9% change in the company's P/S Multiple.| (LTM values as of) | 10312025 | 5212026 | Change |
|---|---|---|---|
| Stock Price ($) | 2.52 | 4.54 | 80.2% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 17 | 8 | -50.2% |
| P/S Multiple | 18.4 | 69.9 | 279.9% |
| Shares Outstanding (Mil) | 123 | 129 | -4.8% |
| Cumulative Contribution | 80.2% |
Market Drivers
10/31/2025 to 5/21/2026| Return | Correlation | |
|---|---|---|
| ACRS | 80.2% | |
| Market (SPY) | 9.5% | 0.6% |
| Sector (XLV) | 3.6% | 7.5% |
Fundamental Drivers
The 229.0% change in ACRS stock from 4/30/2025 to 5/21/2026 was primarily driven by a 893.5% change in the company's P/S Multiple.| (LTM values as of) | 4302025 | 5212026 | Change |
|---|---|---|---|
| Stock Price ($) | 1.38 | 4.54 | 229.0% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 19 | 8 | -55.3% |
| P/S Multiple | 7.0 | 69.9 | 893.5% |
| Shares Outstanding (Mil) | 95 | 129 | -25.9% |
| Cumulative Contribution | 229.0% |
Market Drivers
4/30/2025 to 5/21/2026| Return | Correlation | |
|---|---|---|
| ACRS | 229.0% | |
| Market (SPY) | 35.5% | 4.8% |
| Sector (XLV) | 7.3% | 12.8% |
Fundamental Drivers
The -48.9% change in ACRS stock from 4/30/2023 to 5/21/2026 was primarily driven by a -71.9% change in the company's Total Revenues ($ Mil).| (LTM values as of) | 4302023 | 5212026 | Change |
|---|---|---|---|
| Stock Price ($) | 8.89 | 4.54 | -48.9% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 30 | 8 | -71.9% |
| P/S Multiple | 19.9 | 69.9 | 250.7% |
| Shares Outstanding (Mil) | 67 | 129 | -48.2% |
| Cumulative Contribution | -48.9% |
Market Drivers
4/30/2023 to 5/21/2026| Return | Correlation | |
|---|---|---|
| ACRS | -48.9% | |
| Market (SPY) | 85.6% | 13.6% |
| Sector (XLV) | 16.6% | 12.8% |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| ACRS Return | 125% | 8% | -93% | 136% | 21% | 50% | -30% |
| Peers Return | 23% | 20% | 15% | 7% | 31% | -5% | 127% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 9% | 98% |
Monthly Win Rates [3] | |||||||
| ACRS Win Rate | 50% | 58% | 33% | 58% | 50% | 80% | |
| Peers Win Rate | 57% | 63% | 57% | 57% | 60% | 48% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 60% | |
Max Drawdowns [4] | |||||||
| ACRS Max Drawdown | -59% | -43% | -96% | -46% | -58% | -37% | |
| Peers Max Drawdown | -22% | -19% | -22% | -26% | -27% | -19% | |
| S&P 500 Max Drawdown | -5% | -25% | -10% | -8% | -19% | -9% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: INCY, ABBV, REGN, LLY, AMGN. See ACRS Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/21/2026 (YTD)
How Low Can It Go
| Event | ACRS | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -53.2% | -18.8% |
| % Gain to Breakeven | 113.9% | 23.1% |
| Time to Breakeven | 194 days | 79 days |
| 2024 Yen Carry Trade Unwind | ||
| % Loss | -10.2% | -7.8% |
| % Gain to Breakeven | 11.4% | 8.5% |
| Time to Breakeven | 7 days | 18 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -33.2% | -24.5% |
| % Gain to Breakeven | 49.8% | 32.4% |
| Time to Breakeven | 35 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -41.9% | -33.7% |
| % Gain to Breakeven | 72.0% | 50.9% |
| Time to Breakeven | 26 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -59.1% | -19.2% |
| % Gain to Breakeven | 144.4% | 23.8% |
| Time to Breakeven | 763 days | 105 days |
| 2016-2017 Trump Reflation Bond Selloff | ||
| % Loss | -18.8% | -3.7% |
| % Gain to Breakeven | 23.2% | 3.9% |
| Time to Breakeven | 10 days | 6 days |
In The Past
Aclaris Therapeutics's stock fell -53.2% during the 2025 US Tariff Shock. Such a loss loss requires a 113.9% gain to breakeven.
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| Event | ACRS | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -53.2% | -18.8% |
| % Gain to Breakeven | 113.9% | 23.1% |
| Time to Breakeven | 194 days | 79 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -33.2% | -24.5% |
| % Gain to Breakeven | 49.8% | 32.4% |
| Time to Breakeven | 35 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -41.9% | -33.7% |
| % Gain to Breakeven | 72.0% | 50.9% |
| Time to Breakeven | 26 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -59.1% | -19.2% |
| % Gain to Breakeven | 144.4% | 23.8% |
| Time to Breakeven | 763 days | 105 days |
In The Past
Aclaris Therapeutics's stock fell -53.2% during the 2025 US Tariff Shock. Such a loss loss requires a 113.9% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
About Aclaris Therapeutics (ACRS)
AI Analysis | Feedback
Here are 1-3 brief analogies to describe Aclaris Therapeutics (ACRS):
- A biotech like Amgen or Regeneron, but much smaller and still developing its future drugs in clinical trials.
- A clinical-stage biotech focused on finding its next blockbuster drug for autoimmune conditions, much like a young Gilead Sciences before its major breakthroughs.
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```html- Zunsemetinib: An MK2 inhibitor developed for the treatment of moderate to severe rheumatoid and psoriatic arthritis, and hidradenitis suppurativa.
- ATI-1777: A soft JAK 1/3 inhibitor designed for the treatment of moderate to severe atopic dermatitis.
- ATI-2138: An ITK/TXK/JAK3 inhibitor being developed as a potential treatment for T cell-mediated autoimmune diseases.
- Gut-Biased Program: A therapeutic program focused on developing treatments for inflammatory bowel disease.
- ATI-2231: An MK2 inhibitor currently in development for the treatment of pancreatic and metastatic breast cancer.
- Contract Research Services: Provision of laboratory services to external clients.
AI Analysis | Feedback
Aclaris Therapeutics (ACRS) is a clinical-stage biopharmaceutical company that develops novel drug candidates and also provides laboratory services through its Contract Research segment. Based on this, the company primarily sells to other companies rather than directly to individuals.
For its Therapeutics segment, as a developer of drug candidates still in clinical trials, Aclaris' "customers" would typically be other pharmaceutical or biotechnology companies that might license, partner with, or acquire its drug candidates for further development and eventual commercialization. Examples of its drug candidates include Zunsemetinib, ATI-1777, and ATI-2138.
For its Contract Research segment, Aclaris provides laboratory services. The customers for these services would generally be other pharmaceutical companies, biotechnology firms, or academic research institutions requiring specialized laboratory support.
However, the provided background information does not list the names of any specific major customer companies for either its therapeutic candidates or its contract research services.
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Dr. Neal Walker, Chief Executive Officer and Chair of Board of Directors
Dr. Neal Walker co-founded Aclaris Therapeutics in 2012 and has served as its Chief Executive Officer, including an interim period from January 2024 to February 2025, and as Chair of its Board of Directors since January 2023. He is a board-certified dermatologist and a serial entrepreneur with over 20 years of experience in the life science industry. Dr. Walker co-founded NeXeption, LLC, a biopharmaceutical assets management company, in 2012. Before Aclaris, he co-founded and served as President and CEO of Vicept Therapeutics, Inc. from 2009 until its acquisition by Allergan, Inc. in 2011. He also co-founded and led Octagon Research Solutions, Inc., which was acquired by Accenture plc, and Trigenesis Therapeutics, Inc., where he was Chief Medical Officer, which was acquired by Dr. Reddy's Laboratories Inc. Additionally, Dr. Walker founded Cutix Inc., a commercial dermatology company.
Kevin Balthaser, Chief Financial Officer
Kevin Balthaser has served as Aclaris' Chief Financial Officer since January 2023. He joined Aclaris in 2017 and held various roles of increasing responsibility, including Vice President, Finance since January 2022. Prior to joining Aclaris, Mr. Balthaser held several positions within the accounting and finance department at Lannett Company, Inc., a publicly traded generic pharmaceutical company, where he was involved in executing capital market transactions and acquisitions.
Hugh Davis, PhD, President & Chief Operating Officer
Dr. Hugh Davis has served as Aclaris' Director, President, and Chief Operating Officer, and a member of the Board of Directors, since November 2024. Before joining Aclaris, Dr. Davis held various leadership roles at Biosion, Inc., a biopharmaceutical company, including Chief Operating Officer, President of Biosion USA, Inc., and Chief Business & Development Officer and President. He also served on the Board of Directors of Biosion, Inc. from March 2020.
Roland Kolbeck, PhD, Chief Scientific Officer
Dr. Roland Kolbeck has served as Aclaris' Chief Scientific Officer since July 2025. He brings nearly three decades of senior R&D leadership experience from both small and large biopharmaceutical companies. Most recently, he was the Chief Scientific Officer for Spirovant Sciences. Previously, Dr. Kolbeck served as Vice President and Head of Respiratory, Inflammation and Autoimmune (RIA) research at MedImmune, where six monoclonal antibodies from his portfolio received FDA approval.
Jesse Hall, MD, Chief Medical Officer
Dr. Jesse Hall was appointed as Aclaris' Chief Medical Officer, effective April 2025. He possesses decades of experience in all phases of drug development, from early development to global regulatory filings and approvals. Before joining Aclaris, Dr. Hall most recently served as Chief Medical Officer for AltruBio. His prior experience includes roles of increasing responsibility at companies such as Sublimity Therapeutics, Ardea Biosciences (an AstraZeneca subsidiary), Amgen, and Abbott Labs, where he contributed to the successful launch of monoclonal antibodies like HUMIRA® and PROLIA®.
AI Analysis | Feedback
Aclaris Therapeutics, Inc. (ACRS) faces several significant risks inherent to its nature as a clinical-stage biopharmaceutical company. The company's future success is heavily reliant on the outcome of its drug development pipeline.
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Clinical Trial Success and Regulatory Approval Risk: As a clinical-stage biopharmaceutical company, Aclaris Therapeutics' viability hinges on the successful completion of its drug candidates' clinical trials and subsequent regulatory approvals. The inherent uncertainties in the conduct of clinical trials pose a paramount risk. Failure at any stage of development (Phase 1, 2, or 3) or an inability to secure approval from regulatory bodies for its leading drug candidates, such as bosakitug, ATI-052, and ATI-2138, would severely impact the company. The company has a history of trial failures, which adds to this risk.
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Financial Stability and Need for Future Funding: Aclaris Therapeutics operates at a substantial loss, with a reported net margin of -900.01% and an operating margin of -418.06%. While the company reported having cash, cash equivalents, and marketable securities of $151.4 million as of December 31, 2025, which it expects to fund operations into the second half of 2028, its significant cash burn and negative profitability are ongoing concerns. The Altman Z-Score, a measure of bankruptcy risk, has placed Aclaris in the "distress zone," implying a potential risk of bankruptcy within the next two years. Analysts also anticipate a significant decline in revenue over the next three years, contrasting with industry growth projections, which could exacerbate financial challenges and necessitate further financing or lead to dilution of shareholder value.
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Competition and Commercialization Risk: The markets for immuno-inflammatory diseases, Aclaris Therapeutics' primary focus, are highly competitive. Even if its drug candidates successfully navigate clinical trials and receive regulatory approval, there is a substantial risk of poor commercial performance due to the competitive landscape. For example, a first-generation drug (Tezepelumab) previously failed in atopic dermatitis, an indication Aclaris is targeting. Furthermore, Aclaris acknowledges that its next-generation ITK program, ATI-9494, may be approximately 12 months behind competitors in terms of timing, which could affect its market penetration and commercial success.
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Aclaris Therapeutics, Inc. (ACRS) is developing several drug candidates for various immuno-inflammatory diseases. The addressable markets for their main products and services are as follows:
- Zunsemetinib (MK2 inhibitor):
- Moderate to Severe Rheumatoid Arthritis: The global rheumatoid arthritis market was valued at approximately USD 67.9 billion in 2023 and is projected to reach USD 104.5 billion by 2032. The market across the seven major pharmaceutical markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan) was US$ 28.0 billion in 2024 and is expected to reach US$ 34.7 billion by 2035. The U.S. rheumatoid arthritis market was approximately USD 19 billion in 2023.
- Psoriatic Arthritis: The global psoriatic arthritis market size was valued at USD 14.74 billion in 2024 and is projected to reach USD 30.25 billion by 2032. Another estimate places the global market at USD 12.18 billion in 2024, expected to reach around USD 25.89 billion by 2034. The U.S. psoriatic arthritis treatment market size was USD 3.58 billion in 2024 and is projected to be worth around USD 7.76 billion by 2034.
- Hidradenitis Suppurativa: The hidradenitis suppurativa market across the seven major pharmaceutical markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan) is forecast to grow from USD 1.84 billion in 2024 to USD 7.83 billion in 2034. The top 7 major markets (US, EU4, UK, and Japan) for hidradenitis suppurativa reached a value of USD 1.5 billion in 2024 and are expected to reach USD 4.4 billion by 2035.
- ATI-1777 (soft JAK 1/3 inhibitor):
- Moderate to Severe Atopic Dermatitis: The global atopic dermatitis treatment market was valued at USD 17.05 billion in 2024 and is expected to reach USD 32.04 billion by 2032. Other estimates place the global market at USD 19.10 billion in 2025, estimated to reach USD 41.57 billion by 2034. North America dominated the global market for atopic dermatitis treatment in 2025.
- ATI-2138 (ITK/TXK/JAK3 inhibitor):
- T cell-mediated autoimmune diseases: ATI-2138 is being developed for atopic dermatitis, psoriasis, inflammatory dermatoses, arthritis, inflammatory bowel disease, and ulcerative colitis. The market sizes for some of these specific indications are provided above (Atopic Dermatitis, Psoriatic Arthritis, Rheumatoid Arthritis) and below (Inflammatory Bowel Disease).
- Gut-Biased Program:
- Inflammatory Bowel Disease (IBD): The global inflammatory bowel disease treatment market was USD 26.6 billion in 2024 and is expected to grow to USD 47.3 billion in 2034. Another source states the global market was USD 21 billion in 2024 and is projected to reach USD 26.5 billion by 2030. The U.S. inflammatory bowel disease treatment market was valued at USD 16.6 billion in 2024.
- ATI-2231 (MK2 inhibitor):
- Pancreatic Cancer: The global pancreatic cancer treatment market size was estimated at USD 2.92 billion in 2024 and is projected to reach USD 5.84 billion by 2030. Other projections show the global market at USD 3.25 billion in 2025, projected to surpass USD 10.25 billion by 2034. North America dominated the pancreatic cancer treatment market in 2024. The U.S. pancreatic cancer treatment market size was USD 1.75 billion in 2025 and is projected to hit around USD 5.46 billion by 2035.
- Metastatic Breast Cancer: The global metastatic breast cancer therapeutics market is projected to grow from USD 21.80 billion in 2024 to USD 51.22 billion in 2032. Another estimate for the global metastatic breast cancer treatment market was USD 17.13 billion in 2021 and is expected to reach USD 41.74 billion by 2030. The U.S. market for HER2-positive metastatic breast cancer (a specific subtype) was over USD 1,600 million (USD 1.6 billion) in 2023.
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Aclaris Therapeutics (ACRS) has several expected drivers of future revenue growth over the next 2-3 years, primarily stemming from its clinical-stage pipeline and strategic development plans:
- Advancement and Potential Commercialization of ATI-052: Aclaris' bispecific anti-TSLP/IL-4Rα antibody, ATI-052, is a key growth driver. Following positive interim Phase 1a results, Phase 1b trials have been initiated for atopic dermatitis and asthma, with Phase 2b trials for these conditions anticipated in late 2026. A Phase 2 bosakitug readout is also planned for 2026. Successful progression through these clinical stages and eventual regulatory approval and commercialization could significantly contribute to future revenue.
- Strategic Partnerships and Licensing for ATI-1777: The company's topical "soft" JAK 1/3 inhibitor, ATI-1777, demonstrated positive efficacy in its Phase 2b study for mild to severe atopic dermatitis. Aclaris plans to seek a development and commercialization partner for this program, potentially expanding into additional indications such as vitiligo. Any successful partnership or licensing agreement could provide substantial upfront payments, milestone payments, and future royalties.
- Expansion into Oncology with Zunsemetinib: Although previously discontinued for immuno-inflammatory diseases due to trial failures, Aclaris is now exploring zunsemetinib as a potential treatment for pancreatic cancer and metastatic breast cancer. A successful pivot into the oncology market with this repurposed drug would open up a new, significant revenue stream for the company.
- Continued Development of ATI-2138: ATI-2138, an ITK/TXK/JAK3 inhibitor, has shown promising results in a murine model for alopecia areata. While the company is reassessing the most effective development pathway and indication selection for this drug, successful clinical development and potential commercialization for T cell-mediated autoimmune diseases could serve as another driver of revenue growth.
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Share Issuance- On March 10, 2026, Aclaris Therapeutics sold 5.7 million shares of its common stock, generating gross proceeds of $20.0 million.
- From March 2-9, 2026, the company sold 12.7 million shares of common stock for aggregate gross proceeds of $39.8 million.
- On January 20, 2021, Aclaris Therapeutics priced an underwritten public offering of 5,483,714 shares of common stock at $17.50 per share, anticipating gross proceeds of approximately $96.0 million.
- In March 2026, newly issued shares totaling 5.7 million were purchased by Frazier Life Sciences, Kalehua Capital, and Adage Capital Partners LP.
- From March 2-9, 2026, 12.7 million shares were acquired by institutional investors, including Deep Track Capital.
- Research and development expenses significantly increased to $52.6 million for the year ended December 31, 2025, from $33.6 million in the prior year, driven primarily by higher product candidate manufacturing and preclinical and clinical development costs.
- As of December 31, 2025, Aclaris Therapeutics held $151.4 million in cash, cash equivalents, and marketable securities, which management expects to fund operations into the second half of 2028.
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Peer Comparisons
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 275.96 |
| Mkt Cap | 124.5 |
| Rev LTM | 26,070 |
| Op Inc LTM | 7,205 |
| FCF LTM | 6,194 |
| FCF 3Y Avg | 2,647 |
| CFO LTM | 7,884 |
| CFO 3Y Avg | 7,458 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 9.3% |
| Rev Chg 3Y Avg | 9.5% |
| Rev Chg Q | 20.0% |
| QoQ Delta Rev Chg LTM | 4.1% |
| Op Inc Chg LTM | 51.7% |
| Op Inc Chg 3Y Avg | 10.4% |
| Op Mgn LTM | 27.7% |
| Op Mgn 3Y Avg | 25.7% |
| QoQ Delta Op Mgn LTM | 1.3% |
| CFO/Rev LTM | 28.6% |
| CFO/Rev 3Y Avg | 25.1% |
| FCF/Rev LTM | 24.3% |
| FCF/Rev 3Y Avg | 21.7% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 124.5 |
| P/S | 5.5 |
| P/Op Inc | 17.3 |
| P/EBIT | 14.2 |
| P/E | 19.2 |
| P/CFO | 15.1 |
| Total Yield | 5.6% |
| Dividend Yield | 0.6% |
| FCF Yield 3Y Avg | 4.8% |
| D/E | 0.0 |
| Net D/E | -0.0 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | 2.9% |
| 3M Rtn | -3.9% |
| 6M Rtn | -2.0% |
| 12M Rtn | 36.4% |
| 3Y Rtn | 58.1% |
| 1M Excs Rtn | -2.3% |
| 3M Excs Rtn | -11.6% |
| 6M Excs Rtn | -15.5% |
| 12M Excs Rtn | 8.1% |
| 3Y Excs Rtn | -23.9% |
FDA Approved Drugs Data
Expand for More| Post-Approval Fwd Returns | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| FDA App # | Brand Name | Generic Name | Dosage Form | FDA Approval | 3M Rtn | 6M Rtn | 1Y Rtn | 2Y Rtn | Total Rtn |
| NDA209305 | ESKATA | hydrogen peroxide | solution | 12142017 | -24.0% | -20.0% | -70.4% | -92.4% | -81.6% |
Segment Financials
Revenue by Segment| $ Mil | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|
| Identifying and developing innovative therapies to address significant unmet needs for immuno | 19 | ||||
| Contract Research | 20 | 17 | 13 | 13 | |
| Intersegment Elimination | -17 | 0 | |||
| Therapeutics | 28 | 25 | 1 | 1 | |
| Non-segment general and administrative | -13 | -8 | -8 | ||
| Total | 19 | 31 | 30 | 7 | 6 |
| $ Mil | 2025 | 2024 | 2023 | 2022 | 2021 |
|---|---|---|---|---|---|
| Identifying and developing innovative therapies to address significant unmet needs for immuno | -142 | ||||
| Contract Research | -4 | -2 | -1 | -2 | |
| Intersegment Elimination | 0 | ||||
| Non-segment general and administrative | -28 | -22 | -21 | -18 | |
| Therapeutics | -66 | -66 | -68 | -31 | |
| Total | -142 | -97 | -90 | -90 | -51 |
Price Behavior
| Market Price | $4.54 | |
| Market Cap ($ Bil) | 0.6 | |
| First Trading Date | 10/07/2015 | |
| Distance from 52W High | -10.8% | |
| 50 Days | 200 Days | |
| DMA Price | $4.16 | $2.99 |
| DMA Trend | up | up |
| Distance from DMA | 9.2% | 52.0% |
| 3M | 1YR | |
| Volatility | 69.5% | 97.6% |
| Downside Capture | 156.05 | -15.52 |
| Upside Capture | 233.29 | 138.45 |
| Correlation (SPY) | 39.9% | 4.4% |
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 2.15 | 1.97 | 2.08 | -0.11 | 0.33 | 0.93 |
| Up Beta | 2.62 | 1.71 | 2.14 | 1.60 | 1.18 | 0.44 |
| Down Beta | 0.71 | 1.88 | 1.03 | -4.42 | -1.59 | 0.75 |
| Up Capture | 174% | 372% | 323% | 191% | 176% | 224% |
| Bmk +ve Days | 15 | 22 | 31 | 66 | 141 | 428 |
| Stock +ve Days | 13 | 23 | 33 | 63 | 123 | 353 |
| Down Capture | -53% | 92% | 175% | 17% | 7% | 112% |
| Bmk -ve Days | 4 | 18 | 30 | 56 | 108 | 321 |
| Stock -ve Days | 8 | 18 | 29 | 58 | 111 | 354 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with ACRS | |
|---|---|---|---|---|
| ACRS | 235.6% | 97.7% | 1.61 | - |
| Sector ETF (XLV) | 12.0% | 14.7% | 0.55 | 11.4% |
| Equity (SPY) | 26.8% | 12.1% | 1.67 | 4.1% |
| Gold (GLD) | 37.5% | 26.8% | 1.16 | 6.3% |
| Commodities (DBC) | 43.5% | 18.6% | 1.80 | -7.2% |
| Real Estate (VNQ) | 12.0% | 13.4% | 0.59 | -2.1% |
| Bitcoin (BTCUSD) | -27.2% | 41.8% | -0.65 | -1.8% |
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Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with ACRS | |
|---|---|---|---|---|
| ACRS | -26.6% | 92.6% | 0.23 | - |
| Sector ETF (XLV) | 5.4% | 14.6% | 0.19 | 16.4% |
| Equity (SPY) | 13.8% | 17.0% | 0.64 | 18.0% |
| Gold (GLD) | 19.3% | 18.0% | 0.87 | 6.5% |
| Commodities (DBC) | 10.8% | 19.4% | 0.44 | 1.8% |
| Real Estate (VNQ) | 3.8% | 18.8% | 0.10 | 15.3% |
| Bitcoin (BTCUSD) | 9.3% | 55.6% | 0.37 | 8.0% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with ACRS | |
|---|---|---|---|---|
| ACRS | -12.4% | 110.3% | 0.34 | - |
| Sector ETF (XLV) | 9.8% | 16.5% | 0.48 | 15.7% |
| Equity (SPY) | 15.5% | 17.9% | 0.74 | 16.3% |
| Gold (GLD) | 13.2% | 16.0% | 0.68 | 5.1% |
| Commodities (DBC) | 7.8% | 17.9% | 0.35 | 5.7% |
| Real Estate (VNQ) | 5.4% | 20.7% | 0.22 | 11.3% |
| Bitcoin (BTCUSD) | 67.3% | 66.9% | 1.06 | 3.8% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Returns Analyses
Earnings Returns History
Expand for More| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 5/7/2026 | 1.7% | 6.5% | |
| 2/26/2026 | -5.4% | -6.3% | 6.3% |
| 11/6/2025 | 0.4% | 6.6% | 45.1% |
| 8/7/2025 | 1.3% | 9.7% | 35.5% |
| 5/8/2025 | 4.8% | -5.6% | 22.4% |
| 2/27/2025 | -7.1% | -11.9% | -22.9% |
| 11/6/2024 | 1.8% | 15.3% | 71.6% |
| 8/7/2024 | -2.5% | -2.5% | -3.3% |
| ... | |||
| SUMMARY STATS | |||
| # Positive | 15 | 12 | 14 |
| # Negative | 10 | 13 | 10 |
| Median Positive | 2.7% | 8.2% | 19.2% |
| Median Negative | -5.9% | -9.7% | -21.2% |
| Max Positive | 7.7% | 24.3% | 71.6% |
| Max Negative | -10.9% | -16.5% | -81.6% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 03/31/2026 | 05/07/2026 | 10-Q |
| 12/31/2025 | 02/26/2026 | 10-K |
| 09/30/2025 | 11/06/2025 | 10-Q |
| 06/30/2025 | 08/07/2025 | 10-Q |
| 03/31/2025 | 05/08/2025 | 10-Q |
| 12/31/2024 | 02/27/2025 | 10-K |
| 09/30/2024 | 11/06/2024 | 10-Q |
| 06/30/2024 | 08/07/2024 | 10-Q |
| 03/31/2024 | 05/07/2024 | 10-Q |
| 12/31/2023 | 02/27/2024 | 10-K |
| 09/30/2023 | 11/06/2023 | 10-Q |
| 06/30/2023 | 08/07/2023 | 10-Q |
| 03/31/2023 | 05/08/2023 | 10-Q |
| 12/31/2022 | 02/23/2023 | 10-K |
| 09/30/2022 | 11/08/2022 | 10-Q |
| 06/30/2022 | 08/03/2022 | 10-Q |
Insider Activity
Expand for More| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Leonard, Braden Michael | Holdings of BML Investment Partners, L.P. | Sell | 4272026 | 4.53 | 300,000 | 1,359,000 | 63,193,500 | Form |
Industry Resources
External Quote Links
| Y Finance | Barrons |
| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |
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