Tearsheet

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0  Weak multi-year price returns
2Y Excs Rtn is -161%, 3Y Excs Rtn is -173%
Penny stock
Mkt Price is 0.8
1   High stock price volatility
Vol 12M is 124%
0 Weak multi-year price returns
2Y Excs Rtn is -161%, 3Y Excs Rtn is -173%
1 Penny stock
Mkt Price is 0.8
2 High stock price volatility
Vol 12M is 124%

Market Valuation & Key Metrics

NLSP Stock


Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
NLSP Return--16%-54%-91%-64%-97%
Peers Return-15%-9%-6%-3%-3%-16%-43%
S&P 500 Return16%27%-19%24%23%16%110%

Monthly Win Rates [3]
NLSP Win Rate-18%50%50%25%44% 
Peers Win Rate18%15%23%31%22%51% 
S&P 500 Win Rate58%75%42%67%75%67% 

Max Drawdowns [4]
NLSP Max Drawdown---69%-75%-92%-38% 
Peers Max Drawdown-20%-13%-14%-15%-30%-27% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, APM, BBOT, GDTC, HIND.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 10/30/2025 (YTD)

How Low Can It Go

Unique KeyEventNLSPS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-94.5%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1728.1%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days

Compare to VRTX, APM, BBOT, GDTC, HIND


In The Past

NLS Pharmaceutics's stock fell -94.5% during the 2022 Inflation Shock from a high on 3/12/2021. A -94.5% loss requires a 1728.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About NLS Pharmaceutics (NLSP)

Trade Ideas

Select past ideas related to NLSP. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for NLS Pharmaceutics

Financials

NLSPVRTXAPMBBOTGDTCHINDMedian
NameNLS Phar.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Price0.76419.891.4712.002.155.583.87
Mkt Cap-107.8----107.8
Rev LTM-11,419-0--5,709
Op Inc LTM--199--93---146
FCF LTM-3,500--60--1,720
FCF 3Y Avg-1,984----1,984
CFO LTM-3,846--60--1,893
CFO 3Y Avg-2,324----2,324

Growth & Margins

NLSPVRTXAPMBBOTGDTCHINDMedian
NameNLS Phar.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Rev Chg LTM-10.5%----10.5%
Rev Chg 3Y Avg-11.0%----11.0%
Rev Chg Q-12.1%----12.1%
QoQ Delta Rev Chg LTM-2.9%----2.9%
Op Mgn LTM--1.7%-----1.7%
Op Mgn 3Y Avg-26.5%----26.5%
QoQ Delta Op Mgn LTM-2.0%----2.0%
CFO/Rev LTM-33.7%----33.7%
CFO/Rev 3Y Avg-22.5%----22.5%
FCF/Rev LTM-30.6%----30.6%
FCF/Rev 3Y Avg-19.2%----19.2%

Valuation

NLSPVRTXAPMBBOTGDTCHINDMedian
NameNLS Phar.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Cap-107.8----107.8
P/S-9.4----9.4
P/EBIT-24.5----24.5
P/E-29.6----29.6
P/CFO-28.0----28.0
Total Yield-3.4%----3.4%
Dividend Yield-0.0%----0.0%
FCF Yield 3Y Avg-2.1%----2.1%
D/E-0.0----0.0
Net D/E--0.0-----0.0

Returns

NLSPVRTXAPMBBOTGDTCHINDMedian
NameNLS Phar.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
1M Rtn-58.4%7.2%-27.2%3.6%8.0%7.7%5.4%
3M Rtn-58.6%-8.1%-5.2%-14.4%--6.6%
6M Rtn-49.2%-15.8%59.8%--6.5%--11.2%
12M Rtn-80.3%-11.6%5.0%--3.4%--7.5%
3Y Rtn-96.4%34.6%-76.8%----76.8%
1M Excs Rtn-64.8%2.2%-34.2%-1.9%5.3%-0.2%-1.1%
3M Excs Rtn-67.0%-18.5%-2.1%-8.1%--10.3%
6M Excs Rtn-70.9%-37.6%38.0%--28.3%--32.9%
12M Excs Rtn-98.6%-29.0%-17.8%--33.2%--31.1%
3Y Excs Rtn-173.0%-41.0%-151.9%----151.9%

Financials

Short Interest

Short Interest: As Of Date10152025
Short Interest: Shares Quantity95,155
Short Interest: % Change Since 9302025-75.3%
Average Daily Volume206,275
Days-to-Cover Short Interest1

SEC Filings

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Report DateFiling DateFiling
6302025100620256-K 6/30/2025
12312024516202520-F 12/31/2024
6302024101820246-K 6/30/2024
12312023515202420-F 12/31/2023
6302023120620236-K 6/30/2023
12312022505202320-F 12/31/2022
6302022101120226-K 6/30/2022
12312021324202220-F 12/31/2021
630202192820216-K 6/30/2021
12312020514202120-F 12/31/2020
123120192012021424B4 12/31/2019
123120182282020F-1 12/31/2018

Insider Activity

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