Tearsheet

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more.
Weak multi-year price returns
2Y Excs Rtn is -134%, 3Y Excs Rtn is -161%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185%
1  Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104%
3   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46%
5   High stock price volatility
Vol 12M is 106%
0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more.
1 Weak multi-year price returns
2Y Excs Rtn is -134%, 3Y Excs Rtn is -161%
2 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185%
4 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56%
5 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104%
6 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46%
8 High stock price volatility
Vol 12M is 106%

Valuation, Metrics & Events

DNA Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

Here are the key points for why Ginkgo Bioworks (DNA) stock moved by -28.9% in the approximate time period from August 31, 2025, to December 4, 2025: 1. Ginkgo Bioworks reported a significant miss on its third-quarter 2025 earnings per share (EPS) and revenue estimates. The company disclosed its Q3 results on November 6, 2025, which showed a loss of $1.45 per share, compared to analyst estimates for a loss of $1.24 per share.

2. The company experienced a substantial year-over-year decline in total revenue. Total revenue for the third quarter of 2025 was reported at $39 million, marking a 56% decrease from $89 million in the comparable prior year period. This prior year figure included $45 million in non-cash revenue from a terminated customer agreement, but even excluding this, total revenue still decreased by 11% year-over-year. Specifically, Cell Engineering revenue fell by 61%, or slightly decreased when adjusting for the previous year's non-cash revenue.

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Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
DNA Return---80%0%-85%-13%-97%
Peers Return6%-1%-7%-13%-25%2%-34%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
DNA Win Rate-50%25%42%42%50% 
Peers Win Rate29%21%25%27%15%40% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
DNA Max Drawdown---80%-33%-92%-43% 
Peers Max Drawdown-19%-10%-17%-24%-25%-2% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, ACSB, AIXC, ALPS, APRI.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)

How Low Can It Go

Unique KeyEventDNAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-92.4%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1208.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days

Compare to VRTX, ACSB, AIXC, ALPS, APRI


In The Past

Ginkgo Bioworks's stock fell -92.4% during the 2022 Inflation Shock from a high on 11/8/2021. A -92.4% loss requires a 1208.8% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Ginkgo Bioworks (DNA)

Better Bets than Ginkgo Bioworks (DNA)

Latest Trefis Analyses

Trade Ideas

Select past ideas related to DNA. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Ginkgo Bioworks

Peers to compare with:

Financials

DNAVRTXACSBAIXCALPSAPRIMedian
NameGinkgo B.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Mkt Price9.01463.13-2.541.07-5.78
Mkt Cap0.5118.4----59.4
Rev LTM18111,723-0--181
Op Inc LTM-333-92--5---92
FCF LTM-1873,337--6---6
FCF 3Y Avg-3272,064--10---10
CFO LTM-1663,718--6---6
CFO 3Y Avg-2812,419--10---10

Growth & Margins

DNAVRTXACSBAIXCALPSAPRIMedian
NameGinkgo B.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Rev Chg LTM-17.1%10.3%-----3.4%
Rev Chg 3Y Avg-29.4%10.5%-----9.5%
Rev Chg Q-56.4%11.0%-----22.7%
QoQ Delta Rev Chg LTM-21.8%2.7%-----9.5%
Op Mgn LTM-184.5%-0.8%-----92.7%
Op Mgn 3Y Avg-235.0%26.2%-----104.4%
QoQ Delta Op Mgn LTM-55.7%1.0%-----27.4%
CFO/Rev LTM-91.8%31.7%-----30.0%
CFO/Rev 3Y Avg-118.0%23.1%-----47.5%
FCF/Rev LTM-103.6%28.5%-----37.6%
FCF/Rev 3Y Avg-136.7%19.8%-----58.4%

Valuation

DNAVRTXACSBAIXCALPSAPRIMedian
NameGinkgo B.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Mkt Cap0.5118.4----59.4
P/S4.58.5----6.5
P/EBIT-2.122.4----10.2
P/E-2.427.2----12.4
P/CFO-4.926.9----11.0
Total Yield-41.9%3.7%-----19.1%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-41.8%2.3%-----19.8%
D/E0.50.0----0.3
Net D/E-0.0-0.0-----0.0

Returns

DNAVRTXACSBAIXCALPSAPRIMedian
NameGinkgo B.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
1M Rtn-29.6%8.7%-----10.4%
3M Rtn-20.5%16.8%-----1.9%
6M Rtn19.2%3.9%----11.5%
12M Rtn-7.4%1.3%-----3.0%
3Y Rtn-88.7%44.1%-----22.3%
1M Excs Rtn-29.5%8.7%-----10.4%
3M Excs Rtn-28.2%11.3%-----8.4%
6M Excs Rtn4.5%-10.8%-----3.2%
12M Excs Rtn-10.0%-14.6%-----12.3%
3Y Excs Rtn-160.6%-25.9%-----93.2%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity7,043,448
Short Interest: % Change Since 10312025-1.7%
Average Daily Volume1,475,377
Days-to-Cover Short Interest4.77
Basic Shares Quantity55,633,718
Short % of Basic Shares12.7%

SEC Filings

Expand for More

Report DateFiling DateFiling
93020251106202510-Q 9/30/2025
6302025807202510-Q 6/30/2025
3312025506202510-Q 3/31/2025
12312024225202510-K 12/31/2024
93020241112202410-Q 9/30/2024
6302024808202410-Q 6/30/2024
3312024509202410-Q 3/31/2024
12312023229202410-K 12/31/2023
93020231108202310-Q 9/30/2023
6302023809202310-Q 6/30/2023
3312023510202310-Q 3/31/2023
12312022313202310-K 12/31/2022
93020221114202210-Q 9/30/2022
6302022815202210-Q 6/30/2022
3312022516202210-Q 3/31/2022
12312021329202210-K 12/31/2021