Tearsheet

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more.
Weak multi-year price returns
2Y Excs Rtn is -133%, 3Y Excs Rtn is -156%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185%
1  Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104%
3   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46%
5   High stock price volatility
Vol 12M is 105%
0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more.
1 Weak multi-year price returns
2Y Excs Rtn is -133%, 3Y Excs Rtn is -156%
2 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185%
4 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56%
5 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104%
6 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46%
8 High stock price volatility
Vol 12M is 105%

Valuation, Metrics & Events

DNA Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback


1. Q3 2025 Earnings Miss: Ginkgo Bioworks reported a significant miss on its third-quarter 2025 earnings per share and revenue. The company announced a loss of $1.45 per share, which was higher than analysts' estimates of a $1.24 per share loss, and its quarterly sales of $38.8 million fell short of the consensus estimate of $38.9 million. The GAAP net loss for Q3 2025 worsened to $(81) million, compared to $(56) million in Q3 2024.

2. Significant Revenue Decline: Total revenue for Q3 2025 sharply declined by 56% to $39 million, down from $89 million in the same period last year. This substantial drop was primarily due to a $45 million non-cash revenue component in the prior year from a terminated customer deal. Even excluding this one-time impact, total revenue still saw an 11% year-over-year decrease. Cell Engineering revenue also decreased by 61%, or slightly less when excluding the non-cash revenue from the previous year.

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Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
DNA Return---80%0%-85%-4%-97%
Peers Return176%10%-62%-2%-12%-23%-23%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
DNA Win Rate-50%25%42%42%50% 
Peers Win Rate54%34%28%47%43%50% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
DNA Max Drawdown---80%-33%-92%-43% 
Peers Max Drawdown-17%-30%-72%-51%-40%-48% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: TWST, CDXS, ABCL, RXRX, NTLA.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/8/2025 (YTD)

How Low Can It Go

Unique KeyEventDNAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-92.4%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1208.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days

Compare to VRTX, ACSB, AIXC, ALPS, APRI


In The Past

Ginkgo Bioworks's stock fell -92.4% during the 2022 Inflation Shock from a high on 11/8/2021. A -92.4% loss requires a 1208.8% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Ginkgo Bioworks (DNA)

Better Bets than Ginkgo Bioworks (DNA)

Latest Trefis Analyses

Trade Ideas

Select past ideas related to DNA. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
11.5%11.5%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-8.4%-8.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.2%2.2%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.4%9.4%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
9.5%9.5%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
11.5%11.5%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-8.4%-8.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.2%2.2%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.4%9.4%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
9.5%9.5%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Ginkgo Bioworks

Peers to compare with:

Financials

DNATWSTCDXSABCLRXRXNTLAMedian
NameGinkgo B.Twist Bi.Codexis AbCeller.Recursio.Intellia. 
Mkt Price9.4032.221.923.594.829.447.11
Mkt Cap0.51.90.21.12.21.01.1
Rev LTM1813625335435855
Op Inc LTM-333-142-60-247-724-479-290
FCF LTM-187-69-62-153-450-413-170
FCF 3Y Avg-327-103-50-140-354-394-233
CFO LTM-166-51-56-105-441-411-135
CFO 3Y Avg-281-81-46-73-339-386-181

Growth & Margins

DNATWSTCDXSABCLRXRXNTLAMedian
NameGinkgo B.Twist Bi.Codexis AbCeller.Recursio.Intellia. 
Rev Chg LTM-17.1%22.7%-17.9%7.2%-32.8%33.5%-5.0%
Rev Chg 3Y Avg-29.4%25.3%-25.0%-39.7%23.2%5.8%-9.6%
Rev Chg Q-56.4%17.9%-33.0%37.6%-80.9%51.3%-7.5%
QoQ Delta Rev Chg LTM-21.8%4.2%-7.4%7.4%-32.7%8.8%-1.6%
Op Mgn LTM-184.5%-39.3%-112.7%-699.7%-1,666.6%-832.2%-442.1%
Op Mgn 3Y Avg-235.0%-65.1%-93.2%-661.1%-980.6%-1,006.0%-448.1%
QoQ Delta Op Mgn LTM-55.7%5.6%-12.5%102.7%-659.5%136.5%-3.4%
CFO/Rev LTM-91.8%-14.1%-105.7%-296.0%-1,016.2%-713.8%-200.8%
CFO/Rev 3Y Avg-118.0%-30.0%-74.5%-215.8%-686.3%-765.6%-166.9%
FCF/Rev LTM-103.6%-19.0%-116.5%-433.4%-1,037.0%-717.3%-275.0%
FCF/Rev 3Y Avg-136.7%-38.1%-81.6%-389.7%-715.3%-782.2%-263.2%

Valuation

DNATWSTCDXSABCLRXRXNTLAMedian
NameGinkgo B.Twist Bi.Codexis AbCeller.Recursio.Intellia. 
Mkt Cap0.51.90.21.12.21.01.1
P/S4.56.14.242.650.233.119.6
P/EBIT-2.1-13.1-3.7-6.1-3.1-4.0-3.8
P/E-2.4-25.9-3.4-8.8-3.0-4.3-3.9
P/CFO-4.9-43.2-3.9-14.4-4.9-4.6-4.9
Total Yield-41.9%-3.9%-29.0%-11.4%-32.8%-23.4%-26.2%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-41.8%-6.6%-26.9%-13.7%-18.5%-17.9%-18.2%
D/E0.50.00.30.10.00.10.1
Net D/E-0.0-0.10.0-0.2-0.3-0.2-0.1

Returns

DNATWSTCDXSABCLRXRXNTLAMedian
NameGinkgo B.Twist Bi.Codexis AbCeller.Recursio.Intellia. 
1M Rtn5.0%6.4%13.6%-8.2%4.3%-0.8%4.7%
3M Rtn-16.0%22.7%-21.6%-13.9%4.3%-20.3%-15.0%
6M Rtn19.9%-3.4%-19.3%43.0%-10.2%14.0%5.3%
12M Rtn-19.4%-38.9%-59.4%19.7%-39.8%-35.9%-37.4%
3Y Rtn-87.1%31.9%-65.7%-65.7%-44.1%-75.1%-65.7%
1M Excs Rtn-18.7%3.3%-7.5%-22.6%2.5%-25.3%-13.1%
3M Excs Rtn-17.8%23.3%-26.8%-20.5%-2.6%-25.7%-19.1%
6M Excs Rtn5.9%-17.4%-33.3%29.0%-24.2%0.0%-8.7%
12M Excs Rtn-22.2%-51.0%-73.2%11.3%-44.9%-47.3%-46.1%
3Y Excs Rtn-156.1%-52.3%-133.8%-140.7%-116.1%-147.3%-137.3%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity7,043,448
Short Interest: % Change Since 10312025-1.7%
Average Daily Volume1,475,377
Days-to-Cover Short Interest4.77
Basic Shares Quantity55,633,718
Short % of Basic Shares12.7%

Earnings Returns History

Expand for More

 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/6/2025-20.8%-29.2% 
8/7/2025-8.7%-4.2%-16.9%
5/6/202514.7%25.9%12.1%
2/25/2025-11.5%-21.1%-35.4%
11/12/20242.5%-23.1%23.1%
5/9/2024-17.3%-8.8%-44.5%
2/29/2024-15.1%-21.1%-26.3%
11/8/2023-15.4%4.7%-8.7%
...
SUMMARY STATS   
# Positive644
# Negative91111
Median Positive4.8%7.6%17.6%
Median Negative-12.9%-21.1%-21.6%
Max Positive22.7%25.9%37.0%
Max Negative-20.8%-29.2%-44.5%

SEC Filings

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Report DateFiling DateFiling
93020251106202510-Q 9/30/2025
6302025807202510-Q 6/30/2025
3312025506202510-Q 3/31/2025
12312024225202510-K 12/31/2024
93020241112202410-Q 9/30/2024
6302024808202410-Q 6/30/2024
3312024509202410-Q 3/31/2024
12312023229202410-K 12/31/2023
93020231108202310-Q 9/30/2023
6302023809202310-Q 6/30/2023
3312023510202310-Q 3/31/2023
12312022313202310-K 12/31/2022
93020221114202210-Q 9/30/2022
6302022815202210-Q 6/30/2022
3312022516202210-Q 3/31/2022
12312021329202210-K 12/31/2021