Ginkgo Bioworks (DNA)
Market Price (12/4/2025): $9.04 | Market Cap: $502.9 MilSector: Health Care | Industry: Biotechnology
Ginkgo Bioworks (DNA)
Market Price (12/4/2025): $9.04Market Cap: $502.9 MilSector: Health CareIndustry: Biotechnology
Investment Highlights
Why It Matters
Which of these 2 stories sounds closer for this stock?
1. Generates cash flow
The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.
2. Riding a trend
Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more. | Weak multi-year price returns2Y Excs Rtn is -134%, 3Y Excs Rtn is -161% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185% |
| Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13% | Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56% | |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104% | ||
| Valuation getting more expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245% | ||
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46% | ||
| High stock price volatilityVol 12M is 106% |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Advanced Materials. Themes include Synthetic Biology, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -134%, 3Y Excs Rtn is -161% |
| Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -333 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -185% |
| Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -17%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -29%, Rev Chg QQuarterly Revenue Change % is -56% |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -92%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -104% |
| Valuation getting more expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 245% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -46% |
| High stock price volatilityVol 12M is 106% |
Valuation, Metrics & Events
DNA Stock
Why The Stock Moved
Qualitative Assessment
AI Generated Analysis | Feedback
Here are the key points for why Ginkgo Bioworks (DNA) stock moved by -28.9% in the approximate time period from August 31, 2025, to December 4, 2025:
1. Ginkgo Bioworks reported a significant miss on its third-quarter 2025 earnings per share (EPS) and revenue estimates. The company disclosed its Q3 results on November 6, 2025, which showed a loss of $1.45 per share, compared to analyst estimates for a loss of $1.24 per share.
2. The company experienced a substantial year-over-year decline in total revenue. Total revenue for the third quarter of 2025 was reported at $39 million, marking a 56% decrease from $89 million in the comparable prior year period. This prior year figure included $45 million in non-cash revenue from a terminated customer agreement, but even excluding this, total revenue still decreased by 11% year-over-year. Specifically, Cell Engineering revenue fell by 61%, or slightly decreased when adjusting for the previous year's non-cash revenue.
Stock Movement Drivers
Return vs. Risk
Price Returns Compared
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| DNA Return | - | - | -80% | 0% | -85% | -13% | -97% |
| Peers Return | 6% | -1% | -7% | -13% | -25% | 2% | -34% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 16% | 112% |
Monthly Win Rates [3] | |||||||
| DNA Win Rate | - | 50% | 25% | 42% | 42% | 50% | |
| Peers Win Rate | 29% | 21% | 25% | 27% | 15% | 40% | |
| S&P 500 Win Rate | 58% | 75% | 42% | 67% | 75% | 70% | |
Max Drawdowns [4] | |||||||
| DNA Max Drawdown | - | - | -80% | -33% | -92% | -43% | |
| Peers Max Drawdown | -19% | -10% | -17% | -24% | -25% | -2% | |
| S&P 500 Max Drawdown | -31% | -1% | -25% | -1% | -2% | -15% | |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, ACSB, AIXC, ALPS, APRI.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)
How Low Can It Go
| Event | DNA | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -92.4% | -25.4% |
| % Gain to Breakeven | 1208.8% | 34.1% |
| Time to Breakeven | Not Fully Recovered days | 464 days |
Compare to VRTX, ACSB, AIXC, ALPS, APRI
In The Past
Ginkgo Bioworks's stock fell -92.4% during the 2022 Inflation Shock from a high on 11/8/2021. A -92.4% loss requires a 1208.8% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth over time.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
Latest Trefis Analyses
Trade Ideas
Select past ideas related to DNA. For more, see Trefis Trade Ideas.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 11142025 | CRL | Charles River Laboratories International | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 4.1% | 4.1% | -3.7% |
| 11142025 | GDRX | GoodRx | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -9.8% | -9.8% | -11.8% |
| 11142025 | ASTH | Astrana Health | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 6.0% | 6.0% | -5.5% |
| 11142025 | SGRY | Surgery Partners | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 9.7% | 9.7% | -1.4% |
| 11072025 | TFX | Teleflex | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 6.2% | 6.2% | -5.1% |
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 11142025 | CRL | Charles River Laboratories International | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 4.1% | 4.1% | -3.7% |
| 11142025 | GDRX | GoodRx | Dip Buy | DB | CFO/Rev | Low D/EDip Buy with High Cash Flow MarginsBuying dips for companies with significant cash flows from operations and reasonable debt / market cap | -9.8% | -9.8% | -11.8% |
| 11142025 | ASTH | Astrana Health | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 6.0% | 6.0% | -5.5% |
| 11142025 | SGRY | Surgery Partners | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | 9.7% | 9.7% | -1.4% |
| 11072025 | TFX | Teleflex | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 6.2% | 6.2% | -5.1% |
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for Ginkgo Bioworks
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 5.78 |
| Mkt Cap | 59.4 |
| Rev LTM | 181 |
| Op Inc LTM | -92 |
| FCF LTM | -6 |
| FCF 3Y Avg | -10 |
| CFO LTM | -6 |
| CFO 3Y Avg | -10 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | -3.4% |
| Rev Chg 3Y Avg | -9.5% |
| Rev Chg Q | -22.7% |
| QoQ Delta Rev Chg LTM | -9.5% |
| Op Mgn LTM | -92.7% |
| Op Mgn 3Y Avg | -104.4% |
| QoQ Delta Op Mgn LTM | -27.4% |
| CFO/Rev LTM | -30.0% |
| CFO/Rev 3Y Avg | -47.5% |
| FCF/Rev LTM | -37.6% |
| FCF/Rev 3Y Avg | -58.4% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 59.4 |
| P/S | 6.5 |
| P/EBIT | 10.2 |
| P/E | 12.4 |
| P/CFO | 11.0 |
| Total Yield | -19.1% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | -19.8% |
| D/E | 0.3 |
| Net D/E | -0.0 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | -10.4% |
| 3M Rtn | -1.9% |
| 6M Rtn | 11.5% |
| 12M Rtn | -3.0% |
| 3Y Rtn | -22.3% |
| 1M Excs Rtn | -10.4% |
| 3M Excs Rtn | -8.4% |
| 6M Excs Rtn | -3.2% |
| 12M Excs Rtn | -12.3% |
| 3Y Excs Rtn | -93.2% |
Returns Analyses
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 9302025 | 11062025 | 10-Q 9/30/2025 |
| 6302025 | 8072025 | 10-Q 6/30/2025 |
| 3312025 | 5062025 | 10-Q 3/31/2025 |
| 12312024 | 2252025 | 10-K 12/31/2024 |
| 9302024 | 11122024 | 10-Q 9/30/2024 |
| 6302024 | 8082024 | 10-Q 6/30/2024 |
| 3312024 | 5092024 | 10-Q 3/31/2024 |
| 12312023 | 2292024 | 10-K 12/31/2023 |
| 9302023 | 11082023 | 10-Q 9/30/2023 |
| 6302023 | 8092023 | 10-Q 6/30/2023 |
| 3312023 | 5102023 | 10-Q 3/31/2023 |
| 12312022 | 3132023 | 10-K 12/31/2022 |
| 9302022 | 11142022 | 10-Q 9/30/2022 |
| 6302022 | 8152022 | 10-Q 6/30/2022 |
| 3312022 | 5162022 | 10-Q 3/31/2022 |
| 12312021 | 3292022 | 10-K 12/31/2021 |
Industry Resources
External Quote Links
| Y Finance | Barrons |
| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |