Tearsheet

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -24%
Weak multi-year price returns
2Y Excs Rtn is -78%, 3Y Excs Rtn is -147%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -247 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -700%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Autonomous Technologies, and Artificial Intelligence. Themes include Biopharmaceutical R&D, Show more.
Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 18%
Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -40%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -296%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -433%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -16%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -24%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Autonomous Technologies, and Artificial Intelligence. Themes include Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -78%, 3Y Excs Rtn is -147%
3 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 18%
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -247 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -700%
5 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -40%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -296%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -433%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -16%

Valuation, Metrics & Events

ABCL Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

Here are five key points highlighting why AbCellera Biologics (ABCL) stock moved by approximately -16.5% between August 31, 2025, and December 4, 2025: 1. AbCellera Biologics reported a wider net loss and an earnings per share (EPS) miss for its third quarter of 2025. The company's net loss widened to $57.1 million, compared to $51.1 million in Q3 2024, and reported an EPS of $(0.19) per share, which missed analyst estimates of $(0.162) to $(0.17) per share. While revenue exceeded expectations, the widening loss likely concerned investors, leading to a negative market reaction, including an initial 3.75% drop in after-hours trading following the announcement on November 6, 2025.

2. An analyst downgrade contributed to negative sentiment. On November 7, 2025, Leerink Partners downgraded AbCellera Biologics from an "Outperform" rating to "Market Perform" and set a new price target of $4.00. Such a downgrade from a notable firm can significantly impact investor confidence and contribute to a stock's decline.

Show more

Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
ABCL Return--64%-29%-44%-49%18%-91%
Peers Return6%-1%-7%-13%-25%2%-34%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
ABCL Win Rate 33%42%42%42%60% 
Peers Win Rate29%21%25%27%15%40% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
ABCL Max Drawdown--68%-60%-61%-58%-34% 
Peers Max Drawdown-19%-10%-17%-24%-25%-2% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, ACSB, AIXC, ALPS, APRI.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)

How Low Can It Go

Unique KeyEventABCLS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-92.7%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1260.6%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-33.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven51.0%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days

Compare to VRTX, ACSB, AIXC, ALPS, APRI


In The Past

AbCellera Biologics's stock fell -92.7% during the 2022 Inflation Shock from a high on 2/1/2021. A -92.7% loss requires a 1260.6% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About AbCellera Biologics (ABCL)

Better Bets than AbCellera Biologics (ABCL)

Trade Ideas

Select past ideas related to ABCL. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for AbCellera Biologics

Peers to compare with:

Financials

ABCLVRTXACSBAIXCALPSAPRIMedian
NameAbCeller.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Mkt Price3.49463.13-2.541.07-3.02
Mkt Cap1.0118.4----59.7
Rev LTM3511,723-0--35
Op Inc LTM-247-92--5---92
FCF LTM-1533,337--6---6
FCF 3Y Avg-1402,064--10---10
CFO LTM-1053,718--6---6
CFO 3Y Avg-732,419--10---10

Growth & Margins

ABCLVRTXACSBAIXCALPSAPRIMedian
NameAbCeller.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Rev Chg LTM7.2%10.3%----8.7%
Rev Chg 3Y Avg-39.7%10.5%-----14.6%
Rev Chg Q37.6%11.0%----24.3%
QoQ Delta Rev Chg LTM7.4%2.7%----5.1%
Op Mgn LTM-699.7%-0.8%-----350.2%
Op Mgn 3Y Avg-661.1%26.2%-----317.5%
QoQ Delta Op Mgn LTM102.7%1.0%----51.8%
CFO/Rev LTM-296.0%31.7%-----132.1%
CFO/Rev 3Y Avg-215.8%23.1%-----96.4%
FCF/Rev LTM-433.4%28.5%-----202.5%
FCF/Rev 3Y Avg-389.7%19.8%-----185.0%

Valuation

ABCLVRTXACSBAIXCALPSAPRIMedian
NameAbCeller.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
Mkt Cap1.0118.4----59.7
P/S42.68.5----25.5
P/EBIT-6.122.4----8.2
P/E-8.827.2----9.2
P/CFO-14.426.9----6.3
Total Yield-11.4%3.7%-----3.9%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-13.7%2.3%-----5.7%
D/E0.10.0----0.1
Net D/E-0.2-0.0-----0.1

Returns

ABCLVRTXACSBAIXCALPSAPRIMedian
NameAbCeller.Vertex P.Acesis AIxCryptoALPS Aprinoia. 
1M Rtn-35.0%8.7%-----13.1%
3M Rtn-12.5%16.8%----2.1%
6M Rtn44.2%3.9%----24.0%
12M Rtn19.9%1.3%----10.6%
3Y Rtn-72.5%44.1%-----14.2%
1M Excs Rtn-35.0%8.7%-----13.1%
3M Excs Rtn-21.5%11.3%-----5.1%
6M Excs Rtn29.5%-10.8%----9.3%
12M Excs Rtn2.4%-14.6%-----6.1%
3Y Excs Rtn-147.1%-25.9%-----86.5%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Discovery and development of antibody drugs38    
Licensing revenue 121  
Milestone payments 1815 
Research fees 41192012
Royalty revenue 443327198 
Total3848537523312


Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity54,443,811
Short Interest: % Change Since 10312025-1.3%
Average Daily Volume5,900,042
Days-to-Cover Short Interest9.23
Basic Shares Quantity298,875,174
Short % of Basic Shares18.2%

SEC Filings

Expand for More

Report DateFiling DateFiling
93020251106202510-Q 9/30/2025
6302025807202510-Q 6/30/2025
3312025508202510-Q 3/31/2025
12312024227202510-K 12/31/2024
93020241104202410-Q 9/30/2024
6302024806202410-Q 6/30/2024
3312024507202410-Q 3/31/2024
12312023220202410-K 12/31/2023
93020231102202310-Q 9/30/2023
6302023803202310-Q 6/30/2023
3312023504202310-Q 3/31/2023
12312022221202310-K 12/31/2022
93020221108202210-Q 9/30/2022
6302022809202210-Q 6/30/2022
3312022510202210-Q 3/31/2022
12312021225202210-K 12/31/2021

Insider Activity

Expand for More

 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Thermopylae Holdings Ltd. 3112025Buy2.16343,631742,243121,270,262Form
1Montalbano John S. 3102025Buy2.3025,00057,500393,300Form
2Montalbano John S. 3072025Buy2.3460,000140,568342,049Form