CollPlant Biotechnologies (CLGN)
Market Price (11/18/2025): $2.05 | Market Cap: $24.3 MilSector: Health Care | Industry: Biotechnology
CollPlant Biotechnologies (CLGN)
Market Price (11/18/2025): $2.05Market Cap: $24.3 MilSector: Health CareIndustry: Biotechnology
Investment Highlights
Why It Matters
Which of these 2 stories sounds closer for this stock?
1. Generates cash flow
The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.
2. Riding a trend
Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -33% | Weak multi-year price returns2Y Excs Rtn is -114%, 3Y Excs Rtn is -130% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -13 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -555% |
| Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 249% | Weak revenue growthRev Chg QQuarterly Revenue Change % is -28% | |
| Valuation becoming less expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -92% | Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -438%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -447% | |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Regenerative Medicine, Show more. | Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -56% | |
| High stock price volatilityVol 12M is 124% |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -33% |
| Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 249% |
| Valuation becoming less expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -92% |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Regenerative Medicine, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -114%, 3Y Excs Rtn is -130% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -13 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -555% |
| Weak revenue growthRev Chg QQuarterly Revenue Change % is -28% |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -438%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -447% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -56% |
| High stock price volatilityVol 12M is 124% |
Market Valuation & Key Metrics
CLGN Stock
Why The Stock Moved
Qualitative Assessment
AI Generated Analysis | Feedback
1. CollPlant Biotechnologies reported significantly weaker-than-expected Q2 2025 financial results. The company announced an EPS of -$0.28, which missed analysts' consensus estimates of $0.29 by $0.57. Additionally, reported quarterly revenue of $0.18 million was substantially below analysts' expectations of $8.91 million.
2. The company experienced a year-over-year decline in revenue for Q2 2025. CollPlant's revenues for the second quarter of 2025 were $179,000, a decrease from $249,000 reported in the second quarter of 2024.
Stock Movement Drivers
Return vs. Risk
Price Returns Compared
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| CLGN Return | 89% | 52% | -49% | -23% | -44% | -41% | -63% |
| Peers Return | -15% | -9% | -6% | -3% | -3% | -17% | -44% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 13% | 107% |
Monthly Win Rates [3] | |||||||
| CLGN Win Rate | 42% | 42% | 25% | 58% | 33% | 50% | |
| Peers Win Rate | 18% | 15% | 23% | 31% | 22% | 62% | |
| S&P 500 Win Rate | 58% | 75% | 42% | 67% | 75% | 70% | |
Max Drawdowns [4] | |||||||
| CLGN Max Drawdown | 0% | 0% | -71% | -40% | -47% | -62% | |
| Peers Max Drawdown | -20% | -13% | -14% | -15% | -30% | -27% | |
| S&P 500 Max Drawdown | -31% | -1% | -25% | -1% | -2% | -15% | |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, APM, BBOT, GDTC, HIND.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 11/17/2025 (YTD)
How Low Can It Go
| Event | CLGN | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -80.6% | -25.4% |
| % Gain to Breakeven | 414.9% | 34.1% |
| Time to Breakeven | Not Fully Recovered days | 464 days |
| 2020 Covid Pandemic | ||
| % Loss | -54.8% | -33.9% |
| % Gain to Breakeven | 121.3% | 51.3% |
| Time to Breakeven | 65 days | 148 days |
| 2018 Correction | ||
| % Loss | -99.3% | -19.8% |
| % Gain to Breakeven | 13317.9% | 24.7% |
| Time to Breakeven | Not Fully Recovered days | 120 days |
Compare to VRTX, APM, BBOT, GDTC, HIND
In The Past
CollPlant Biotechnologies's stock fell -80.6% during the 2022 Inflation Shock from a high on 2/11/2021. A -80.6% loss requires a 414.9% gain to breakeven.
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Asset Allocation
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Latest Trefis Analyses
| Title | Topic | |
|---|---|---|
| DASHBOARDS | ||
| With CollPlant Biotechnologies Stock Sliding, Have You Assessed The Risk? | Return |
| Title | |
|---|---|
| ARTICLES |
Trade Ideas
Select past ideas related to CLGN. For more, see Trefis Trade Ideas.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 10312025 | GDRX | GoodRx | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | -11.9% | -11.9% | -11.9% |
| 10312025 | DXCM | DexCom | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | -0.3% | -0.3% | -5.8% |
| 10242025 | ACHC | Acadia Healthcare | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | -31.5% | -31.5% | -31.5% |
| 10102025 | PBH | Prestige Consumer Healthcare | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | -1.6% | -1.6% | -1.9% |
| 10032025 | REGN | Regeneron Pharmaceuticals | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 15.6% | 15.6% | -7.0% |
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 10312025 | GDRX | GoodRx | Dip Buy | DB | FCF Yield | Low D/EDip Buy with High Free Cash Flow YieldBuying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap | -11.9% | -11.9% | -11.9% |
| 10312025 | DXCM | DexCom | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | -0.3% | -0.3% | -5.8% |
| 10242025 | ACHC | Acadia Healthcare | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | -31.5% | -31.5% | -31.5% |
| 10102025 | PBH | Prestige Consumer Healthcare | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | -1.6% | -1.6% | -1.9% |
| 10032025 | REGN | Regeneron Pharmaceuticals | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 15.6% | 15.6% | -7.0% |
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons for CollPlant Biotechnologies
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 3.50 |
| Mkt Cap | 55.5 |
| Rev LTM | 2 |
| Op Inc LTM | -92 |
| FCF LTM | -11 |
| FCF 3Y Avg | 1,027 |
| CFO LTM | -11 |
| CFO 3Y Avg | 1,205 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 129.5% |
| Rev Chg 3Y Avg | 323.2% |
| Rev Chg Q | -8.6% |
| QoQ Delta Rev Chg LTM | -0.1% |
| Op Mgn LTM | -278.1% |
| Op Mgn 3Y Avg | -535.5% |
| QoQ Delta Op Mgn LTM | 17.5% |
| CFO/Rev LTM | -203.1% |
| CFO/Rev 3Y Avg | -149.2% |
| FCF/Rev LTM | -209.1% |
| FCF/Rev 3Y Avg | -172.3% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 55.5 |
| P/S | 10.0 |
| P/EBIT | 11.5 |
| P/E | 14.1 |
| P/CFO | 13.7 |
| Total Yield | -24.1% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | -13.6% |
| D/E | 0.1 |
| Net D/E | -0.2 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | -7.9% |
| 3M Rtn | 5.3% |
| 6M Rtn | 10.5% |
| 12M Rtn | -7.9% |
| 3Y Rtn | -60.9% |
| 1M Excs Rtn | -8.0% |
| 3M Excs Rtn | 2.6% |
| 6M Excs Rtn | -1.4% |
| 12M Excs Rtn | -23.0% |
| 3Y Excs Rtn | -130.3% |
Returns Analyses
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 6302025 | 8202025 | 6-K 6/30/2025 |
| 3312025 | 5282025 | 6-K 3/31/2025 |
| 12312024 | 3262025 | 20-F 12/31/2024 |
| 9302024 | 11272024 | 6-K 9/30/2024 |
| 6302024 | 8202024 | 6-K 6/30/2024 |
| 3312024 | 5292024 | 6-K 3/31/2024 |
| 12312023 | 4042024 | 20-F 12/31/2023 |
| 9302023 | 11292023 | 6-K 9/30/2023 |
| 6302023 | 8242023 | 6-K 6/30/2023 |
| 3312023 | 5242023 | 6-K 3/31/2023 |
| 12312022 | 3292023 | 20-F 12/31/2022 |
| 9302022 | 12012022 | 6-K 9/30/2022 |
| 6302022 | 8252022 | 6-K 6/30/2022 |
| 3312022 | 5262022 | 6-K 3/31/2022 |
| 12312021 | 3242022 | 20-F 12/31/2021 |
| 9302021 | 11182021 | 6-K 9/30/2021 |
Industry Resources
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