Tearsheet

Cassava Sciences (SAVA)


Market Price (12/27/2025): $2.175 | Market Cap: $105.1 Mil
Sector: Health Care | Industry: Biotechnology

Cassava Sciences (SAVA)


Market Price (12/27/2025): $2.175
Market Cap: $105.1 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -101%
Weak multi-year price returns
2Y Excs Rtn is -137%, 3Y Excs Rtn is -176%
Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
1 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Alzheimer's Disease Treatment, Biopharmaceutical R&D, Show more.
Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -112 Mil
2   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -105%
3   Key risks
SAVA key risks include [1] the clinical trial failure and discontinuation of its lead drug, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -101%
1 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Alzheimer's Disease Treatment, Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -137%, 3Y Excs Rtn is -176%
3 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14%
4 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -112 Mil
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -105%
7 Key risks
SAVA key risks include [1] the clinical trial failure and discontinuation of its lead drug, Show more.

Valuation, Metrics & Events

SAVA Stock


Why The Stock Moved


Qualitative Assessment

AI Analysis | Feedback

Here are the key points for why Cassava Sciences (SAVA) stock moved by -4.4% for the approximate time period from August 31, 2025, to December 27, 2025:

<b>1. Failed Alzheimer's Drug Trials and Program Discontinuation</b><br><br>

Cassava Sciences faced significant setbacks in its Alzheimer's drug program, with the Phase 3 ReThink-ALZ study of simufilam failing to meet its primary endpoints in November 2024. This led to the discontinuation of all Alzheimer's disease clinical studies, a factor that continued to weigh heavily on investor sentiment into 2025 and contributed to a significant stock plunge in October 2025.

<b>2. FDA Clinical Hold on New Indication Trial</b><br><br>

In 2025, the U.S. Food and Drug Administration (FDA) placed a full clinical hold on Cassava's proposed trial for simufilam in Tuberous Sclerosis Complex (TSC)-related epilepsy. This regulatory hurdle required additional preclinical data and protocol modifications, delaying the initiation of the proof-of-concept trial and disrupting strategic plans.

<b>3. Continued SEC Scrutiny and Financial Settlement Impact</b><br><br>

Ongoing scrutiny from the U.S. Securities and Exchange Commission (SEC) and a $40 million settlement in 2024 over alleged data manipulation continued to impact investor confidence in the company's scientific credibility and management stability throughout 2025.

<b>4. Unproven Strategic Pivot</b><br><br>

Following the abandonment of its primary Alzheimer's program, Cassava Sciences' strategic shift to explore simufilam in TSC-related epilepsy remained unproven by clinical trial results in 2025, contributing to investor uncertainty.

<b>5. Financial Constraints and Operational Losses</b><br><br>

Cassava Sciences experienced financial strain, including significant operational losses in 2024, which deepened investor skepticism into 2025. This highlighted the company's reliance on speculative research and the ongoing need for further capital.

Show more

Stock Movement Drivers

Fundamental Drivers

The -27.1% change in SAVA stock from 9/26/2025 to 12/26/2025 was primarily driven by a 0.0% change in the company's Shares Outstanding (Mil).
926202512262025Change
Stock Price ($)2.992.18-27.09%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)48.3148.310.00%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

9/26/2025 to 12/26/2025
ReturnCorrelation
SAVA-27.1% 
Market (SPY)4.3%40.0%
Sector (XLV)15.2%20.6%

Fundamental Drivers

The 24.6% change in SAVA stock from 6/27/2025 to 12/26/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
627202512262025Change
Stock Price ($)1.752.1824.57%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)48.2648.31-0.10%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

6/27/2025 to 12/26/2025
ReturnCorrelation
SAVA24.6% 
Market (SPY)12.6%24.0%
Sector (XLV)17.0%20.7%

Fundamental Drivers

The -15.8% change in SAVA stock from 12/26/2024 to 12/26/2025 was primarily driven by a -0.7% change in the company's Shares Outstanding (Mil).
1226202412262025Change
Stock Price ($)2.592.18-15.83%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)47.9848.31-0.69%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

12/26/2024 to 12/26/2025
ReturnCorrelation
SAVA-15.8% 
Market (SPY)15.8%18.6%
Sector (XLV)13.3%19.4%

Fundamental Drivers

The -92.4% change in SAVA stock from 12/27/2022 to 12/26/2025 was primarily driven by a -20.6% change in the company's Shares Outstanding (Mil).
1227202212262025Change
Stock Price ($)28.672.18-92.40%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)40.0548.31-20.62%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

12/27/2023 to 12/26/2025
ReturnCorrelation
SAVA-90.3% 
Market (SPY)48.0%14.6%
Sector (XLV)18.2%8.1%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
SAVA Return31%541%-32%-24%-90%-6%-57%
Peers Return16%38%-12%21%26%16%150%
S&P 500 Return16%27%-19%24%23%18%114%

Monthly Win Rates [3]
SAVA Win Rate42%58%33%33%42%67% 
Peers Win Rate52%65%42%68%57%52% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
SAVA Max Drawdown-61%0%-63%-57%-90%-50% 
Peers Max Drawdown-34%-5%-26%-7%-9%-23% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: HPQ, HPE, IBM, CSCO, AAPL. See SAVA Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/26/2025 (YTD)

How Low Can It Go

Unique KeyEventSAVAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-90.7%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven970.4%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-78.9%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven373.0%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven120 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-92.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven1288.2%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven641 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-99.9%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven112800.0%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven851 days1,480 days

Compare to HPQ, HPE, IBM, CSCO, AAPL

In The Past

Cassava Sciences's stock fell -90.7% during the 2022 Inflation Shock from a high on 7/28/2021. A -90.7% loss requires a 970.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Cassava Sciences (SAVA)

Cassava Sciences, Inc., a clinical stage biotechnology company, develops drugs for neurodegenerative diseases. Its lead therapeutic product candidate is simufilam, a small molecule drug, which is completed Phase 2b clinical trial; and investigational diagnostic product candidate is SavaDx, a blood-based biomarker/diagnostic to detect Alzheimer's disease. The company was formerly known as Pain Therapeutics, Inc. and changed its name to Cassava Sciences, Inc. in March 2019. Cassava Sciences, Inc. was incorporated in 1998 and is based in Austin, Texas.

AI Analysis | Feedback

Here are two analogies to describe Cassava Sciences (SAVA):

Analogy 1: A clinical-stage biotechnology company focused on Alzheimer's, akin to a much smaller, earlier-stage Biogen, but with its lead drug candidate under intense scrutiny and allegations regarding the integrity of its scientific data, creating an extremely high-risk, high-reward investment.

Analogy 2: Like a pharmaceutical startup, reminiscent of an early-stage Nikola (NKLA), where its entire market valuation is tied to a single, experimental Alzheimer's drug whose foundational claims are battling serious public allegations of scientific misconduct and data integrity issues.

AI Analysis | Feedback

  • Simufilam: An investigational oral drug candidate currently in Phase 3 clinical trials for the treatment of Alzheimer's disease.
  • SavaDx: An investigational blood-based diagnostic test being developed to detect Alzheimer's disease.

AI Analysis | Feedback

Cassava Sciences (SAVA) is a clinical-stage biotechnology company focused on developing novel treatments for neurodegenerative diseases, primarily simufilam for Alzheimer's disease. As a clinical-stage company, it does not currently have any commercialized products on the market.

Therefore, Cassava Sciences does not have "major customers" in the traditional sense, whether they be other companies or individual consumers. Its activities are primarily research and development, funded by investors, and it is not generating revenue from product sales. Consequently, there are no customer companies or categories of individual customers to list at this time.

AI Analysis | Feedback

  • Catalent, Inc. (CTLT)

AI Analysis | Feedback

Richard J. Barry, President & Chief Executive Officer

Richard J. Barry was appointed Chief Executive Officer of Cassava Sciences in September 2024, after serving as Executive Chairman of the Board since July 2024. He has been a Director of Sarepta Therapeutics, Inc. since June 2015. Mr. Barry has extensive experience in investment management, having been a founding member, Managing General Partner, and Portfolio Manager of Eastbourne Capital Management LLC from 1999 to 2010. Prior to that, he was a Portfolio Manager and Managing Director of Robertson Stephens Investment Management.

Eric Schoen, Chief Financial Officer

Eric Schoen has served as Cassava Sciences' Chief Financial Officer since 2018. Before joining the company, Mr. Schoen was Vice President, Senior Vice President, Finance, and Chief Accounting Officer of Aspira Women's Health Inc. (formerly Vermillion, Inc.), a publicly-held women's health company, from 2011 to 2017. He began his career at PricewaterhouseCoopers, where he spent nine years in audit and assurance, transaction services, and global capital markets practices.

Joseph Hulihan, Chief Medical Officer

Dr. Joseph Hulihan was appointed Chief Medical Officer in August 2025. He brings over 25 years of industry experience, specializing in the development of therapeutics for epilepsy and other neurological disorders. From 2019 to 2025, he served as Chief Medical Officer at Marinus Pharmaceuticals, where he led development programs in rare pediatric epilepsies and for the treatment of status epilepticus. Marinus Pharmaceuticals was acquired by Immedica Pharma in March 2025. Dr. Hulihan also held senior leadership roles in neuroscience drug development and medical affairs at Johnson & Johnson for 15 years.

R. Christopher Cook, Chief Operating and Legal Officer

R. Christopher Cook became Cassava Sciences' Chief Operating and Legal Officer in April 2025, having initially joined the company as Senior Vice President and General Counsel in October 2022. His prior experience includes serving as the Global Head of Litigation and Government Investigations for Alcon, a publicly traded medical device and pharmaceutical company. He also held the position of Vice President and division General Counsel for Walmart Central America and was a litigation partner at Jones Day for seventeen years.

Michael Zamloot, Senior Vice President, Technology Operations

Michael Zamloot has been Cassava Sciences' Senior Vice President, Technology Operations since 2000. He possesses 35 years of pharmaceutical industry experience with multinational firms and development-stage biopharmaceutical companies. His responsibilities encompass all aspects of Pharmaceutical Development, Quality, and Supply Chain Management. Mr. Zamloot is also an inventor on more than 25 patents.

AI Analysis | Feedback

The key risks to Cassava Sciences (SAVA) are as follows:

  1. Clinical Trial Failure and Discontinuation of Lead Drug Candidate: Cassava Sciences' primary drug candidate, simufilam, failed to meet its primary and secondary endpoints in its Phase 3 RETHINK-ALZ clinical trial for mild-to-moderate Alzheimer's disease. This led to the discontinuation of all development efforts for simufilam in Alzheimer's, including another Phase 3 trial and an open-label study, effectively ending its most significant program. The trial's results showed no significant improvement in cognition or daily functioning compared to a placebo.
  2. Regulatory Scrutiny and Allegations of Data Manipulation: The company has faced intense regulatory scrutiny from the Securities and Exchange Commission (SEC) and the Department of Justice (DOJ). Cassava Sciences agreed to pay $40 million to resolve an SEC investigation into allegations of misleading investors with doctored data from a Phase 2b clinical trial of simufilam. Additionally, a co-developer of the drug was separately charged by the SEC for allegedly manipulating data. These issues have raised significant concerns about the company's scientific credibility.
  3. Financial Vulnerability and Lack of Revenue Prospects: With the discontinuation of simufilam for Alzheimer's, Cassava Sciences currently has no approved products and no immediate revenue streams. The company has been burning cash, with operational losses of $63.1 million in 2024. While Cassava has cash and cash equivalents, its cash runway is projected into 2026 or early 2027, and it may require additional funding, which could lead to shareholder dilution. The company is exploring a new indication for simufilam (TSC-related epilepsy), but this program is in preclinical stages and remains unproven.

AI Analysis | Feedback

  • Ongoing scientific and regulatory investigations into allegations of data manipulation and scientific misconduct related to Cassava Sciences' lead drug candidate, simufilam. These investigations, involving bodies like the FDA and NIH, could lead to adverse findings, impacting simufilam's clinical trials, regulatory approval prospects, and the company's overall viability.
  • The increasing market penetration and regulatory validation of competing amyloid-targeting Alzheimer's drugs, such as Biogen/Eisai's Leqembi (lecanemab) and Eli Lilly's donanemab. These therapies are establishing a clear benchmark for efficacy and a validated treatment paradigm in Alzheimer's, creating a high competitive barrier for Cassava Sciences' simufilam, which utilizes a different, less established mechanism of action, especially if its Phase 3 results do not demonstrate superior efficacy or safety.

AI Analysis | Feedback

null

AI Analysis | Feedback

Cassava Sciences (SAVA) is a clinical-stage biotechnology company with its future revenue growth primarily tied to the successful development and commercialization of its lead drug candidate, simufilam, for Alzheimer's disease. Over the next 2-3 years, the expected drivers of revenue growth are:
  1. Regulatory Approval and Commercial Launch of Simufilam: The most significant driver of future revenue for Cassava Sciences is the potential regulatory approval and subsequent commercial launch of simufilam as a novel treatment for Alzheimer's disease. The company has completed the last patient visit for its Phase 3 RETHINK-ALZ trial, with top-line results anticipated before the end of 2024. Successful trial outcomes are crucial for gaining regulatory approval and initiating sales. Cassava Sciences has already begun preparing for potential commercialization, indicating their readiness to bring the drug to market if approved.
  2. Market Penetration and Patient Adoption of Simufilam: Following a potential regulatory approval, the growth in revenue will depend on the company's ability to effectively penetrate the Alzheimer's treatment market and drive patient adoption of simufilam. The size of the Alzheimer's market presents a substantial opportunity. The company's discussions on the implications of their trials for Alzheimer's treatment suggest a focus on positioning simufilam competitively to gain market share.
  3. Expansion of Manufacturing and Commercial Infrastructure: In anticipation of successful trial results and commercialization, Cassava Sciences is expanding its manufacturing capabilities. An increase in research and development (R&D) spending is also expected in the second half of 2024 to support commercial launch preparations. These investments in infrastructure are essential to meet the demand and facilitate the distribution of simufilam, thereby enabling revenue growth.
  4. Development and Commercialization of Companion Diagnostics: Beyond the drug itself, Cassava Sciences has indicated a focus on diagnostics development. If simufilam requires or benefits from a companion diagnostic to identify suitable patients or monitor treatment efficacy, the commercialization of such diagnostics could represent an additional, albeit likely smaller, revenue stream.

AI Analysis | Feedback

Share Issuance

  • In November 2020, Cassava Sciences completed an underwritten public offering of 9,375,000 shares of common stock at $8.00 per share, generating approximately $75.0 million in gross proceeds.
  • In February 2021, the company closed a registered direct offering of 4,081,633 shares of common stock at $49.00 per share, resulting in gross proceeds of approximately $200.0 million.
  • In November 2022, Cassava Sciences completed another registered direct offering of 1,666,667 shares of common stock at $30 per share, raising approximately $50 million in gross proceeds.

Capital Expenditures

  • Cassava Sciences' capital expenditures for the latest twelve months were $74,000.
  • Capital expenditures peaked in December 2021 at $22.214 million, subsequently decreasing to $2.712 million in 2022, $414,000 in 2023, and $103,000 in 2024.
  • The company occupies approximately 25% of an office complex measuring about 90,000 rentable square feet as of December 31, 2024.

Trade Ideas

Select ideas related to SAVA. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
21.4%21.4%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.4%-7.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
18.0%18.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.9%3.9%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
12.2%12.2%-5.1%

Recent Active Movers

More From Trefis

Peer Comparisons for Cassava Sciences

Peers to compare with:

Financials

SAVAHPQHPEIBMCSCOAAPLMedian
NameCassava .HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Price2.1823.2624.49305.0978.16273.4051.32
Mkt Cap0.121.932.6284.9309.24,074.4158.8
Rev LTM055,29534,29665,40257,696408,62556,496
Op Inc LTM-1123,6241,64411,54412,991130,2147,584
FCF LTM-842,80062711,85412,73396,1847,327
FCF 3Y Avg-812,9781,40011,75313,879100,5037,366
CFO LTM-843,6972,91913,48313,744108,5658,590
CFO 3Y Avg-813,6723,89613,49814,736111,5598,697

Growth & Margins

SAVAHPQHPEIBMCSCOAAPLMedian
NameCassava .HP Hewlett .Internat.Cisco Sy.Apple  
Rev Chg LTM-3.2%13.8%4.5%8.9%6.0%6.0%
Rev Chg 3Y Avg--3.9%6.5%2.6%3.7%1.8%2.6%
Rev Chg Q-4.2%14.4%9.1%7.5%9.6%9.1%
QoQ Delta Rev Chg LTM-1.1%3.7%2.1%1.8%2.1%2.1%
Op Mgn LTM-6.6%4.8%17.7%22.5%31.9%17.7%
Op Mgn 3Y Avg-7.4%7.2%16.4%24.2%30.8%16.4%
QoQ Delta Op Mgn LTM--0.2%-1.4%0.6%0.4%0.1%0.1%
CFO/Rev LTM-6.7%8.5%20.6%23.8%26.6%20.6%
CFO/Rev 3Y Avg-6.8%12.7%21.4%26.1%28.4%21.4%
FCF/Rev LTM-5.1%1.8%18.1%22.1%23.5%18.1%
FCF/Rev 3Y Avg-5.5%4.6%18.6%24.6%25.6%18.6%

Valuation

SAVAHPQHPEIBMCSCOAAPLMedian
NameCassava .HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Cap0.121.932.6284.9309.24,074.4158.8
P/S-0.41.04.45.410.04.4
P/EBIT-0.96.819.925.122.531.321.2
P/E-1.08.6572.736.029.941.033.0
P/CFO-1.35.911.221.122.537.516.2
Total Yield-100.7%14.1%2.3%5.0%5.4%2.8%3.9%
Dividend Yield0.0%2.5%2.1%2.2%2.1%0.4%2.1%
FCF Yield 3Y Avg-25.6%10.6%5.5%6.4%6.0%3.1%5.7%
D/E0.00.50.70.20.10.00.2
Net D/E-1.00.30.60.20.00.00.1

Returns

SAVAHPQHPEIBMCSCOAAPLMedian
NameCassava .HP Hewlett .Internat.Cisco Sy.Apple  
1M Rtn-35.7%-1.8%14.4%0.6%2.7%-1.5%-0.4%
3M Rtn-27.1%-11.9%2.7%7.9%17.0%7.1%4.9%
6M Rtn24.6%-4.0%34.5%6.6%15.2%36.3%19.9%
12M Rtn-15.8%-27.3%14.2%39.2%33.7%6.0%10.1%
3Y Rtn-92.4%-3.8%67.7%139.0%79.5%113.4%73.6%
1M Excs Rtn-30.7%-5.6%12.9%-2.2%-0.0%-3.7%-3.0%
3M Excs Rtn-31.4%-16.2%-1.7%3.6%12.7%2.8%0.6%
6M Excs Rtn12.3%-16.3%22.3%-5.7%3.0%24.0%7.6%
12M Excs Rtn-25.5%-42.9%-0.7%25.0%19.9%-8.4%-4.6%
3Y Excs Rtn-175.6%-83.5%-11.2%59.6%-1.2%28.4%-6.2%

Financials

Segment Financials

Assets by Segment
$ Mil20242023202220212020
Development of novel drugs and diagnostics1522352679423
Total1522352679423


Price Behavior

Price Behavior
Market Price$2.18 
Market Cap ($ Bil)0.1 
First Trading Date07/14/2000 
Distance from 52W High-53.0% 
   50 Days200 Days
DMA Price$3.13$2.44
DMA Trendupdown
Distance from DMA-30.3%-10.6%
 3M1YR
Volatility104.8%98.5%
Downside Capture415.74119.42
Upside Capture183.6384.82
Correlation (SPY)39.1%18.5%
SAVA Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta3.493.772.652.380.951.18
Up Beta2.202.682.882.030.701.24
Down Beta1.973.984.262.971.020.59
Up Capture425%518%348%367%94%36%
Bmk +ve Days13263974142427
Stock +ve Days10212960115333
Down Capture375%330%153%190%116%110%
Bmk -ve Days7162452107323
Stock -ve Days9203362127410

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of SAVA With Other Asset Classes (Last 1Y)
 SAVASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-7.2%15.1%17.8%72.1%8.6%4.4%-8.3%
Annualized Volatility98.5%17.2%19.4%19.3%15.2%17.0%35.0%
Sharpe Ratio0.360.650.722.700.340.09-0.08
Correlation With Other Assets 19.4%18.3%8.3%11.5%20.9%18.8%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
 Comparison of SAVA With Other Asset Classes (Last 5Y)
 SAVASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-23.7%8.4%14.7%18.7%11.5%4.6%30.8%
Annualized Volatility135.5%14.5%17.1%15.5%18.7%18.9%48.7%
Sharpe Ratio0.460.400.700.970.500.160.57
Correlation With Other Assets 7.6%16.6%4.0%7.6%9.8%13.9%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of SAVA With Other Asset Classes (Last 10Y)
 SAVASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-16.4%9.9%14.8%15.3%7.0%5.3%69.2%
Annualized Volatility153.0%16.6%18.0%14.7%17.6%20.8%55.8%
Sharpe Ratio0.560.490.710.860.320.220.90
Correlation With Other Assets 11.1%14.0%1.4%6.9%8.7%8.0%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date12152025
Short Interest: Shares Quantity6,852,568
Short Interest: % Change Since 11302025-5.2%
Average Daily Volume760,760
Days-to-Cover Short Interest9.01
Basic Shares Quantity48,308,000
Short % of Basic Shares14.2%

Earnings Returns History

Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/12/20254.8%-10.3%-5.8%
8/14/20255.7%-6.1%-7.5%
3/3/20253.3%17.1%-37.5%
11/7/2024-4.6%-5.2%-87.9%
8/8/2024-13.8%-21.5%-10.9%
5/10/20241.9%14.3%-7.0%
2/28/2024-0.3%-6.9%-11.2%
11/7/20234.3%-8.8%1.5%
...
SUMMARY STATS   
# Positive784
# Negative121115
Median Positive4.8%10.4%20.1%
Median Negative-4.6%-11.1%-10.9%
Max Positive15.1%31.3%71.6%
Max Negative-13.8%-21.8%-87.9%

SEC Filings

Expand for More
Report DateFiling DateFiling
93020251112202510-Q 9/30/2025
6302025814202510-Q 6/30/2025
3312025508202510-Q 3/31/2025
12312024303202510-K 12/31/2024
93020241107202410-Q 9/30/2024
6302024808202410-Q 6/30/2024
3312024510202410-Q 3/31/2024
12312023228202410-K 12/31/2023
93020231107202310-Q 9/30/2023
6302023803202310-Q 6/30/2023
3312023501202310-Q 3/31/2023
12312022228202310-K 12/31/2022
93020221107202210-Q 9/30/2022
6302022804202210-Q 6/30/2022
3312022505202210-Q 3/31/2022
12312021301202210-K 12/31/2021

Insider Activity

Expand for More
 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Anderson Robert Eugene Jr 11252025Buy2.908,60024,94024,940Form
1Barry RichardPresident & CEO11242025Buy2.76150,000414,0002,589,046Form