Tearsheet

Niagen Bioscience (NAGE)


Market Price (12/4/2025): $6.54 | Market Cap: $521.8 Mil
Sector: Health Care | Industry: Biotechnology

Niagen Bioscience (NAGE)


Market Price (12/4/2025): $6.54
Market Cap: $521.8 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 36%
Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 39x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 35x, P/EPrice/Earnings or Price/(Net Income) is 36x
1 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 17%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 17%
 
2 Megatrend and thematic drivers
Megatrends include Health & Wellness Trends, and Aging Population & Chronic Disease. Themes include Nutritional Supplements, and Longevity & Healthy Aging.
 
0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 36%
1 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 17%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 17%
2 Megatrend and thematic drivers
Megatrends include Health & Wellness Trends, and Aging Population & Chronic Disease. Themes include Nutritional Supplements, and Longevity & Healthy Aging.
3 Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 39x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 35x, P/EPrice/Earnings or Price/(Net Income) is 36x

Valuation, Metrics & Events

NAGE Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

Niagen Bioscience (NAGE) experienced a significant stock decline of 34% between August 31, 2025, and December 4, 2025. Here are key factors contributing to this movement:

1. InvestingPro's Overvaluation Alert in July 2025: InvestingPro's Fair Value analysis identified NAGE as significantly overvalued in July 2025, just before a dramatic decline. The model estimated the stock's intrinsic value at $8.01 when it was trading at $12.71, indicating an overvaluation of nearly 37%. This analysis was validated as the stock corrected, falling 35% in July alone, and reaching $6.88 by November 6, 2025, representing a 46% decline from its peak.

2. Q3 2025 Earnings Performance and Market Reaction: Despite reporting strong third-quarter 2025 results on November 4, 2025, with a 33% year-over-year revenue increase to $34.0 million and net income rising to $4.6 million, the stock fell by 3.73% to $7.06 in after-hours trading. This suggests that even positive financial outcomes were not enough to counter negative market sentiment or valuation concerns.

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Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
NAGE Return------ 
Peers Return2%-1%6%8%-0%2%17%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
NAGE Win Rate-----57% 
Peers Win Rate13%8%13%12%10%90% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
NAGE Max Drawdown------ 
Peers Max Drawdown-2%-5%0%-0%-1%-2% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, AIXC, ALPS, BBOT, EVMN.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)

How Low Can It Go

NAGE has limited trading history. Below is the Health Care sector ETF (XLV) in its place.

Unique KeyEventXLVS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-16.1%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven19.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven599 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-28.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven40.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven116 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-15.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven18.8%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven326 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-40.6%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven68.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven1100 days1480 days

Compare to


In The Past

SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.

Preserve Wealth

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Asset Allocation

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About Niagen Bioscience (NAGE)

Better Bets than Niagen Bioscience (NAGE)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select past ideas related to NAGE. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
4.1%4.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-9.8%-9.8%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.0%6.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
9.7%9.7%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
6.2%6.2%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Niagen Bioscience

Peers to compare with:

Financials

NAGEVRTXAIXCALPSBBOTEVMNMedian
NameNiagen B.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Mkt Price6.53463.132.541.0711.0721.228.80
Mkt Cap0.5118.4----59.4
Rev LTM12511,7230-01010
Op Inc LTM19-92-5--93-70-70
FCF LTM213,337-6--60-64-6
FCF 3Y Avg102,064-10---10
CFO LTM213,718-6--60-64-6
CFO 3Y Avg112,419-10---11

Growth & Margins

NAGEVRTXAIXCALPSBBOTEVMNMedian
NameNiagen B.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Rev Chg LTM36.0%10.3%----23.2%
Rev Chg 3Y Avg22.4%10.5%----16.4%
Rev Chg Q32.9%11.0%----21.9%
QoQ Delta Rev Chg LTM7.2%2.7%----4.9%
Op Mgn LTM15.5%-0.8%----700.7%-0.8%
Op Mgn 3Y Avg2.6%26.2%----14.4%
QoQ Delta Op Mgn LTM1.1%1.0%----1.1%
CFO/Rev LTM17.2%31.7%----635.6%17.2%
CFO/Rev 3Y Avg9.7%23.1%----16.4%
FCF/Rev LTM17.0%28.5%----636.5%17.0%
FCF/Rev 3Y Avg9.5%19.8%----14.6%

Valuation

NAGEVRTXAIXCALPSBBOTEVMNMedian
NameNiagen B.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Mkt Cap0.5118.4----59.4
P/S6.08.5----7.3
P/EBIT38.622.4----30.5
P/E36.427.2----31.8
P/CFO34.826.9----30.8
Total Yield2.7%3.7%----3.2%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-2.3%----2.3%
D/E0.00.0----0.0
Net D/E-0.1-0.0-----0.1

Returns

NAGEVRTXAIXCALPSBBOTEVMNMedian
NameNiagen B.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
1M Rtn-9.7%8.7%---9.9%--9.7%
3M Rtn-32.5%16.8%--12.5%-12.5%
6M Rtn-44.3%3.9%-----20.2%
12M Rtn-1.3%----1.3%
3Y Rtn-44.1%----44.1%
1M Excs Rtn-9.6%8.7%---9.9%--9.6%
3M Excs Rtn-35.3%11.3%--4.5%-4.5%
6M Excs Rtn-59.0%-10.8%-----34.9%
12M Excs Rtn--14.6%-----14.6%
3Y Excs Rtn--25.9%-----25.9%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Consumer Products segment706057 36
Ingredients segment1197 6
Analytical Reference Standards and Services segment333 4
Corporate and other00   
Total847267 46


Operating Income by Segment
$ Mil20242023202220212020
Consumer Products segment1476 0
Ingredients segment544 2
Analytical Reference Standards and Services segment-1-0-0 0
Corporate and other-25-28-36 -34
Total-6-19-27 -31


Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity5,634,298
Short Interest: % Change Since 1031202511.0%
Average Daily Volume1,200,868
Days-to-Cover Short Interest4.69
Basic Shares Quantity79,779,000
Short % of Basic Shares7.1%

SEC Filings

Expand for More

Report DateFiling DateFiling
93020251104202510-Q 9/30/2025
6302025806202510-Q 6/30/2025
3312025507202510-Q 3/31/2025
12312024304202510-K 12/31/2024
93020241031202410-Q 9/30/2024
6302024807202410-Q 6/30/2024
3312024508202410-Q 3/31/2024
12312023306202410-K 12/31/2023
93020231108202310-Q 9/30/2023
6302023809202310-Q 6/30/2023
3312023510202310-Q 3/31/2023
12312022308202310-K 12/31/2022
93020221102202210-Q 9/30/2022
6302022810202210-Q 6/30/2022
3312022512202210-Q 3/31/2022
12312021314202210-K 12/31/2021

Insider Activity

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 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Pamir OzanChief Financial Officer11172025Buy6.814,46530,40650,204Form