Tearsheet

Niagen Bioscience (NAGE)


Market Price (10/31/2025): $7.07 | Market Cap: $560.3 Mil
Sector: Health Care | Industry: Biotechnology

Niagen Bioscience (NAGE)


Market Price (10/31/2025): $7.07
Market Cap: $560.3 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -10%
  Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 34x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 27x, P/EPrice/Earnings or Price/(Net Income) is 32x
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 36%
  
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 18%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 18%
  
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -10%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 36%
2 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 18%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is 18%
3 Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 34x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 27x, P/EPrice/Earnings or Price/(Net Income) is 32x

Market Valuation & Key Metrics

NAGE Stock


Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
NAGE Return------0%
Peers Return-15%-9%-6%-3%-3%-16%-43%
S&P 500 Return16%27%-19%24%23%16%110%

Monthly Win Rates [3]
NAGE Win Rate-----67% 
Peers Win Rate18%15%23%31%22%51% 
S&P 500 Win Rate58%75%42%67%75%67% 

Max Drawdowns [4]
NAGE Max Drawdown------ 
Peers Max Drawdown-20%-13%-14%-15%-30%-27% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, APM, BBOT, GDTC, HIND.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 10/30/2025 (YTD)

How Low Can It Go

NAGE has limited trading history. Below is the Health Care sector ETF (XLV) in its place.

Unique KeyEventXLVS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-16.1%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven19.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven599 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-28.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven40.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven116 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-15.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven18.8%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven326 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-40.6%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven68.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven1100 days1480 days

Compare to


In The Past

SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Niagen Bioscience (NAGE)

Better Bets than Niagen Bioscience (NAGE)

Trade Ideas

Select past ideas related to NAGE. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Niagen Bioscience

Financials

NAGEVRTXAPMBBOTGDTCHINDMedian
NameNiagen B.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Price7.11419.891.4712.002.155.586.35
Mkt Cap0.6107.8----54.2
Rev LTM11611,419-0--116
Op Inc LTM17-199--93---93
FCF LTM213,500--60--21
FCF 3Y Avg81,984----996
CFO LTM213,846--60--21
CFO 3Y Avg82,324----1,166

Growth & Margins

NAGEVRTXAPMBBOTGDTCHINDMedian
NameNiagen B.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Rev Chg LTM35.9%10.5%----23.2%
Rev Chg 3Y Avg19.6%11.0%----15.3%
Rev Chg Q36.8%12.1%----24.5%
QoQ Delta Rev Chg LTM7.8%2.9%----5.3%
Op Mgn LTM14.3%-1.7%----6.3%
Op Mgn 3Y Avg0.3%26.5%----13.4%
QoQ Delta Op Mgn LTM2.1%2.0%----2.1%
CFO/Rev LTM18.2%33.7%----26.0%
CFO/Rev 3Y Avg7.3%22.5%----14.9%
FCF/Rev LTM18.0%30.6%----24.3%
FCF/Rev 3Y Avg7.1%19.2%----13.1%

Valuation

NAGEVRTXAPMBBOTGDTCHINDMedian
NameNiagen B.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Cap0.6107.8----54.2
P/S4.89.4----7.1
P/EBIT33.824.5----29.2
P/E31.829.6----30.7
P/CFO26.628.0----27.3
Total Yield3.1%3.4%----3.3%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-2.1%----2.1%
D/E0.00.0----0.0
Net D/E-0.1-0.0-----0.1

Returns

NAGEVRTXAPMBBOTGDTCHINDMedian
NameNiagen B.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
1M Rtn-23.8%7.2%-27.2%3.6%8.0%7.7%5.4%
3M Rtn-24.0%-8.1%-5.2%-14.4%--6.6%
6M Rtn-6.0%-15.8%59.8%--6.5%--6.2%
12M Rtn--11.6%5.0%--3.4%--3.4%
3Y Rtn-34.6%-76.8%----21.1%
1M Excs Rtn-11.5%2.2%-34.2%-1.9%5.3%-0.2%-1.1%
3M Excs Rtn-30.7%-18.5%-2.1%-8.1%--10.3%
6M Excs Rtn-27.7%-37.6%38.0%--28.3%--28.0%
12M Excs Rtn--29.0%-17.8%--33.2%--29.0%
3Y Excs Rtn--41.0%-151.9%----96.5%

Financials

Segment Financials

Revenue by Segment

$ Mil20242023202220212020
Consumer Products segment7060574736
Ingredients segment119796
Analytical Reference Standards and Services segment33334
Corporate and other00   
Total8472675946


Operating Income by Segment
$ Mil20242023202220212020
Consumer Products segment147660
Ingredients segment54452
Analytical Reference Standards and Services segment-1-0-0-00
Corporate and other-25-28-36-31-34
Total-6-19-27-20-31


Short Interest

Short Interest: As Of Date10152025
Short Interest: Shares Quantity4,172,117
Short Interest: % Change Since 930202511.2%
Average Daily Volume1,532,065
Days-to-Cover Short Interest2.72
Basic Shares Quantity79,249,000
Short % of Basic Shares5.3%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/6/20252.2%7.7%0.1%
3/4/2025  
10/31/2024   
8/7/2024   
3/6/2024   
11/8/2023   
8/9/2023   
3/8/2023   
...
SUMMARY STATS   
# Positive112
# Negative171716
Median Positive2.2%7.7%0.1%
Median Negative   
Max Positive2.2%7.7%0.1%
Max Negative   

SEC Filings

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Report DateFiling DateFiling
6302025806202510-Q 6/30/2025
3312025507202510-Q 3/31/2025
12312024304202510-K 12/31/2024
93020241031202410-Q 9/30/2024
6302024807202410-Q 6/30/2024
3312024508202410-Q 3/31/2024
12312023306202410-K 12/31/2023
93020231108202310-Q 9/30/2023
6302023809202310-Q 6/30/2023
3312023510202310-Q 3/31/2023
12312022308202310-K 12/31/2022
93020221102202210-Q 9/30/2022
6302022810202210-Q 6/30/2022
3312022512202210-Q 3/31/2022
12312021314202210-K 12/31/2021
93020211103202110-Q 9/30/2021

Insider Activity

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