Tearsheet

GRAIL (GRAL)


Market Price (10/31/2025): $92.5 | Market Cap: $3.3 Bil
Sector: Health Care | Industry: Life Sciences Tools & Services

GRAIL (GRAL)


Market Price (10/31/2025): $92.5
Market Cap: $3.3 Bil
Sector: Health Care
Industry: Life Sciences Tools & Services

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -17%
Trading close to highs
Dist 52W High is -0.8%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -605 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -450%
1  Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
Stock price has recently run up significantly
6M Rtn6 month market price return is 181%, 12M Rtn12 month market price return is 569%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -276%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -277%
3   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 187%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -18%
5   High stock price volatility
Vol 12M is 114%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -17%
1 Trading close to highs
Dist 52W High is -0.8%
2 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -605 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -450%
4 Stock price has recently run up significantly
6M Rtn6 month market price return is 181%, 12M Rtn12 month market price return is 569%
5 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -276%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -277%
6 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 187%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -18%
8 High stock price volatility
Vol 12M is 114%

Market Valuation & Key Metrics

GRAL Stock


Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
GRAL Return-----411%401%
Peers Return42%3%-9%-5%-14%-18%-12%
S&P 500 Return16%27%-19%24%23%16%110%

Monthly Win Rates [3]
GRAL Win Rate----50%67% 
Peers Win Rate40%33%32%28%42%47% 
S&P 500 Win Rate58%75%42%67%75%67% 

Max Drawdowns [4]
GRAL Max Drawdown------2% 
Peers Max Drawdown-25%-12%-25%-25%-21%-44% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: A, ATEC, CERS, BDMD, PTHL.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 10/30/2025 (YTD)

How Low Can It Go

GRAL has limited trading history. Below is the Health Care sector ETF (XLV) in its place.

Unique KeyEventXLVS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-16.1%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven19.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven599 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-28.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven40.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven116 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-15.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven18.8%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven326 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-40.6%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven68.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven1100 days1480 days

Compare to


In The Past

SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About GRAIL (GRAL)

Better Bets than GRAIL (GRAL)

Trade Ideas

Select past ideas related to GRAL. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for GRAIL

Financials

GRALAATECCERSBDMDPTHLMedian
NameGRAIL Agilent .Alphatec Cerus Baird Me.Pheton  
Mkt Price91.15143.3616.331.401.400.638.86
Mkt Cap3.340.72.40.3--2.9
Rev LTM1346,788682193--437
Op Inc LTM-6051,444-95-12---53
FCF LTM-3721,088-323---14
FCF 3Y Avg-1,308-123-16---16
CFO LTM-3701,495166--11
CFO 3Y Avg-1,662-45-13---13

Growth & Margins

GRALAATECCERSBDMDPTHLMedian
NameGRAIL Agilent .Alphatec Cerus Baird Me.Pheton  
Rev Chg LTM22.4%4.5%26.3%13.3%--17.8%
Rev Chg 3Y Avg-0.8%33.0%7.8%--7.8%
Rev Chg Q11.2%10.1%27.5%16.3%--13.8%
QoQ Delta Rev Chg LTM2.7%2.4%6.2%4.0%--3.4%
Op Mgn LTM-450.5%21.3%-13.9%-6.1%---10.0%
Op Mgn 3Y Avg-21.5%-24.2%-13.8%---13.8%
QoQ Delta Op Mgn LTM80.8%-0.1%4.2%0.5%--2.3%
CFO/Rev LTM-275.6%22.0%2.3%3.0%--2.6%
CFO/Rev 3Y Avg-24.6%-9.6%-8.2%---8.2%
FCF/Rev LTM-276.8%16.0%-4.6%1.8%---1.4%
FCF/Rev 3Y Avg-19.4%-24.6%-10.2%---10.2%

Valuation

GRALAATECCERSBDMDPTHLMedian
NameGRAIL Agilent .Alphatec Cerus Baird Me.Pheton  
Mkt Cap3.340.72.40.3--2.9
P/S24.36.03.61.4--4.8
P/EBIT-5.426.9-18.6-26.7---12.0
P/E-7.433.4-14.7-14.2---10.8
P/CFO-8.827.2156.046.9--37.1
Total Yield-13.6%3.7%-6.8%-7.0%---6.9%
Dividend Yield0.0%0.7%0.0%0.0%--0.0%
FCF Yield 3Y Avg-3.7%-7.3%-4.2%---4.2%
D/E0.00.10.20.4--0.2
Net D/E-0.20.00.20.1--0.1

Returns

GRALAATECCERSBDMDPTHLMedian
NameGRAIL Agilent .Alphatec Cerus Baird Me.Pheton  
1M Rtn54.2%11.7%12.3%-11.9%-34.0%-19.5%-0.1%
3M Rtn166.4%25.1%54.3%9.4%-31.4%-29.6%17.2%
6M Rtn180.5%35.2%47.6%7.7%-74.8%-83.7%21.5%
12M Rtn569.2%9.9%190.6%-18.6%-49.1%-85.1%-4.3%
3Y Rtn-5.9%59.5%-61.7%--5.9%
1M Excs Rtn45.2%1.8%15.2%-9.6%-36.2%-21.6%-3.9%
3M Excs Rtn168.6%17.2%9.2%0.9%-36.1%-32.0%5.0%
6M Excs Rtn158.8%13.5%25.9%-14.0%-96.5%-105.5%-0.3%
12M Excs Rtn587.3%-7.3%192.7%-35.8%-70.5%-103.6%-21.5%
3Y Excs Rtn--67.8%-18.7%-137.9%---67.8%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date10152025
Short Interest: Shares Quantity4,782,809
Short Interest: % Change Since 9302025-4.1%
Average Daily Volume1,023,233
Days-to-Cover Short Interest4.67
Basic Shares Quantity35,793,154
Short % of Basic Shares13.4%

Earnings Returns History

Expand for More

 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/12/20251.1%-6.5%15.0%
5/13/2025-23.3%-8.3%-2.3%
2/20/2025-14.7%-17.7%-36.6%
11/12/20245.5%-2.0%37.7%
8/13/2024-2.8%1.4%-14.5%
SUMMARY STATS   
# Positive212
# Negative343
Median Positive3.3%1.4%26.4%
Median Negative-14.7%-7.4%-14.5%
Max Positive5.5%1.4%37.7%
Max Negative-23.3%-17.7%-36.6%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025813202510-Q 6/30/2025
3312025514202510-Q 3/31/2025
12312024305202510-K 12/31/2024
93020241113202410-Q 9/30/2024
6302024813202410-Q 6/30/2024
3312024529202410-12B/A 3/31/2024
12312023506202410-12B 12/31/2023
123120199092020S-1 12/31/2019

Insider Activity

Expand for More

 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Ofman Joshua J.President8202025Sell32.024,202134,54815,621,725Form
1Freidin AaronChief Financial Officer8202025Sell32.0287728,0829,130,279Form
2Freidin AaronChief Financial Officer7172025Sell38.938,000311,44011,134,759Form
3DING CHUN R 7032025Sell48.8851,1252,498,990175,661,522Form
4Ofman Joshua J.President6162025Sell42.309,692410,01921,227,245Form