Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -28%
Weak multi-year price returns
2Y Excs Rtn is -85%, 3Y Excs Rtn is -114%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -34%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 522%
Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.25, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 15%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
  Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -72%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -72%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -13%
4   Key risks
GERN key risks include [1] its heavy dependence on a single product, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -28%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 522%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -85%, 3Y Excs Rtn is -114%
4 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 10.25, Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -63 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -34%
6 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 15%
7 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -72%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -72%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -13%
9 Key risks
GERN key risks include [1] its heavy dependence on a single product, Show more.

Valuation, Metrics & Events

GERN Stock


Why The Stock Moved


Qualitative Assessment

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The stock of Geron (GERN) experienced a decline of approximately -2.1% around December 26, 2025. Here are some key points that could have contributed to this movement, based on available information and general factors influencing biotech stocks:

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1. Negative Technical Outlook and Bearish Momentum: Geron's technical outlook has been described as bearish, with a weak technical score and several bearish signals observed in the days leading up to December 26, 2025. This suggests a prevailing negative sentiment among traders based on technical indicators.

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2. Mixed Analyst Sentiment and Inconsistent Guidance: While some analysts maintained "Strong Buy" ratings for Geron, the overall performance-weighted rating indicated a bearish outlook. This mismatch between optimistic analyst ratings and the market's cautious stance could contribute to downward pressure on the stock.

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Stock Movement Drivers

Fundamental Drivers

The 6.2% change in GERN stock from 9/27/2025 to 12/27/2025 was primarily driven by a 11.5% change in the company's Total Revenues ($ Mil).
927202512272025Change
Stock Price ($)1.291.376.20%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)164.45183.4011.53%
P/S Multiple5.234.98-4.64%
Shares Outstanding (Mil)666.17667.10-0.14%
Cumulative Contribution6.20%

LTM = Last Twelve Months as of date shown

Market Drivers

9/27/2025 to 12/27/2025
ReturnCorrelation
GERN6.2% 
Market (SPY)4.3%38.7%
Sector (XLV)15.2%36.9%

Fundamental Drivers

The -8.1% change in GERN stock from 6/28/2025 to 12/27/2025 was primarily driven by a -41.6% change in the company's P/S Multiple.
628202512272025Change
Stock Price ($)1.491.37-8.05%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)116.29183.4057.71%
P/S Multiple8.534.98-41.59%
Shares Outstanding (Mil)665.91667.10-0.18%
Cumulative Contribution-8.05%

LTM = Last Twelve Months as of date shown

Market Drivers

6/28/2025 to 12/27/2025
ReturnCorrelation
GERN-8.1% 
Market (SPY)12.6%31.4%
Sector (XLV)17.0%30.3%

Fundamental Drivers

The -59.1% change in GERN stock from 12/27/2024 to 12/27/2025 was primarily driven by a -93.4% change in the company's P/S Multiple.
1227202412272025Change
Stock Price ($)3.351.37-59.10%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)29.48183.40522.13%
P/S Multiple75.254.98-93.38%
Shares Outstanding (Mil)662.16667.10-0.75%
Cumulative Contribution-59.11%

LTM = Last Twelve Months as of date shown

Market Drivers

12/27/2024 to 12/27/2025
ReturnCorrelation
GERN-59.1% 
Market (SPY)17.0%30.5%
Sector (XLV)13.8%33.3%

Fundamental Drivers

The -33.8% change in GERN stock from 12/28/2022 to 12/27/2025 was primarily driven by a -99.1% change in the company's P/S Multiple.
1228202212272025Change
Stock Price ($)2.071.37-33.82%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)1.53183.4011863.67%
P/S Multiple547.194.98-99.09%
Shares Outstanding (Mil)405.24667.10-64.62%
Cumulative Contribution-61.45%

LTM = Last Twelve Months as of date shown

Market Drivers

12/28/2023 to 12/27/2025
ReturnCorrelation
GERN-36.3% 
Market (SPY)48.0%18.1%
Sector (XLV)17.9%19.0%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
GERN Return17%-23%98%-13%68%-60%3%
Peers Return16%38%-12%21%26%16%150%
S&P 500 Return16%27%-19%24%23%18%114%

Monthly Win Rates [3]
GERN Win Rate42%42%58%50%58%25% 
Peers Win Rate52%65%42%68%57%52% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
GERN Max Drawdown-35%-25%-19%-28%-17%-70% 
Peers Max Drawdown-34%-5%-26%-7%-9%-23% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: HPQ, HPE, IBM, CSCO, AAPL.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/26/2025 (YTD)

How Low Can It Go

Unique KeyEventGERNS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-52.9%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven112.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven182 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-40.4%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven67.9%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven58 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-84.6%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven550.0%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-76.5%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven325.1%131.3%
2008 Global Financial CrisisTime to BreakevenTime to BreakevenNot Fully Recovered days1,480 days

Compare to HPQ, HPE, IBM, CSCO, AAPL

In The Past

Geron's stock fell -52.9% during the 2022 Inflation Shock from a high on 2/3/2021. A -52.9% loss requires a 112.1% gain to breakeven.

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About Geron (GERN)

Geron Corporation, a late-stage clinical biopharmaceutical company, focuses on the development and commercialization of therapeutics for myeloid hematologic malignancies. It develops imetelstat, a telomerase inhibitor that is in Phase 3 clinical trials, which inhibits the uncontrolled proliferation of malignant stem and progenitor cells in hematologic myeloid malignancies for the treatment of low or intermediate-1 risk myelodysplastic syndromes and intermediate-2 or high-risk myelofibrosis. The company was incorporated in 1990 and is headquartered in Foster City, California.

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  • An early-stage Moderna, but specializing in a single experimental drug for blood cancers.
  • A focused oncology biotech, similar to Incyte in its specialized approach to blood cancers, but with its value largely tied to its lead experimental drug, imetelstat.

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  • Rytelo (imetelstat): An oligonucleotide telomerase inhibitor approved for the treatment of adult patients with lower-risk myelodysplastic syndromes (MDS) who have become transfusion-dependent and are refractory or ineligible for erythropoiesis-stimulating agents (ESAs).

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Geron (GERN) is a biopharmaceutical company that has recently received FDA approval for its first commercial product, RYTELO™ (imetelstat), for the treatment of adult patients with lower-risk myelodysplastic syndromes (LR-MDS) with transfusion-dependent anemia. As such, Geron sells its product primarily to other companies within the pharmaceutical supply chain rather than directly to individuals.

The major customers for a pharmaceutical manufacturer like Geron are typically large drug wholesalers and specialty distributors. These companies purchase the drug directly from Geron and then distribute it to hospitals, clinics, and specialty pharmacies, which in turn dispense the medication to patients.

Based on standard pharmaceutical distribution models in the United States, Geron's major customers (or those with whom they will establish distribution agreements) would likely include:

  • McKesson Corporation (Symbol: MCK)
  • Cencora (Symbol: COR, formerly AmerisourceBergen Corporation)
  • Cardinal Health, Inc. (Symbol: CAH)

These entities form the backbone of the drug distribution network, ensuring that RYTELO™ can reach the healthcare providers and patients who need it.

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Harout Semerjian, President and Chief Executive Officer, Board of Directors Member

Mr. Semerjian has been the President, Director, and Chief Executive Officer of Geron since August 2025. He brings over 30 years of commercial experience across hematology and oncology. Previously, he served as Chief Executive Officer of GlycoMimetics and Immunomedics. Prior to that, he was the Executive Vice President, Chief Commercial Officer of Ipsen and Head of the U.S. hematology franchise of Novartis. His career includes pivotal contributions to oncology drug launches such as Gleevec and KISQALI.

Michelle Robertson, Executive Vice President, Chief Financial Officer and Treasurer

Ms. Robertson has served as Geron's Executive Vice President, Chief Financial Officer, and Treasurer since September 2023. She has 30 years of financial and commercial operations experience. Prior to joining Geron, she was the Chief Financial Officer and Treasurer of Editas Medicine Inc. from January 2020 to May 2023. Before that, she served as Chief Financial Officer of Momenta Pharmaceuticals from 2018 until 2020, when Momenta was acquired by Johnson & Johnson. Ms. Robertson also held multiple commercial finance roles at Baxalta Inc., Ironwood Pharmaceuticals Inc., and Genzyme Corporation.

Ahmed ElNawawi (“Nawawi”), Executive Vice President, Chief Commercial Officer

Mr. ElNawawi was appointed Executive Vice President, Chief Commercial Officer, effective October 20, 2025. He previously served as Senior Vice President and U.S. Commercial Head at Stemline Therapeutics, where he was responsible for expanding the team and delivering three consecutive years of growth.

Scott A. Samuels, Executive Vice President, Chief Legal Officer and Secretary

Mr. Samuels has served as Geron's Executive Vice President, Chief Legal Officer and Secretary since 2023. His prior roles include Chief Legal Officer and Chief Compliance Officer of Prilenia Therapeutics Inc. and Senior Vice President, General Counsel of BeiGene Ltd. He also served as Assistant General Counsel and Acting General Counsel at ARIAD Pharmaceuticals Inc.

Shannon T. Odam, Senior Vice President and Chief People Officer

Ms. Odam has served as Senior Vice President and Chief People Officer of Geron since January 2024. She joined Geron in June 2019 as Vice President of Human Resources. Prior to Geron, Ms. Odam was Vice President of Human Resources at BioElectron Technology Corp. and held various human capital roles at PricewaterhouseCoopers.

AI Analysis | Feedback

The public company Geron (symbol: GERN) faces several key business risks, primarily centered around its reliance on a single product, intense market competition, and ongoing financial challenges.

  1. Single Product Dependence and Market Saturation: Geron's business is heavily reliant on the success of its flagship product, Rytelo (imetelstat), approved for lower-risk myelodysplastic syndromes (MDS). This singular focus presents a significant risk to the company's long-term stability and growth. Without a diverse product portfolio, Geron is vulnerable to market fluctuations, regulatory changes, or unexpected clinical outcomes related to Rytelo. There is also a risk of sales plateau or decline if the addressable patient population for Rytelo becomes saturated, especially without new pipeline products to drive future growth. The company's third-quarter 2025 report indicated a 3% quarter-over-quarter decline in Rytelo demand, highlighting this near-term risk.
  2. Intense Competition: The hematologic malignancies market is highly competitive, with numerous established pharmaceutical companies and emerging biotechnology firms vying for market share. Geron faces the ongoing challenge of differentiating Rytelo from existing treatments and potential new entrants. Larger pharmaceutical companies with more extensive resources could develop more effective therapies, offer more competitive pricing, or leverage broader market reach, potentially making it difficult for Geron to maintain or expand its market position.
  3. Financial Health and Profitability Concerns: Geron has consistently reported negative earnings per share (EPS) and has been burning through cash. Despite a strong liquidity position with cash exceeding liabilities, financial health indicators such as a low Piotroski F-Score and an Altman Z-Score placing the company in the "distress zone" suggest potential underlying operational challenges and financial distress. Additionally, the company has faced lawsuits alleging false statements regarding Rytelo's potential, which led to a significant stock crash in early 2025.

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Geron's main product, imetelstat (marketed as RYTELO), targets hematological diseases, specifically lower-risk myelodysplastic syndromes (LR-MDS) and relapsed/refractory myelofibrosis (R/R MF). RYTELO is approved in the United States and the European Union for certain adult patients with LR-MDS with transfusion-dependent anemia. The company is also conducting a pivotal Phase 3 clinical trial for imetelstat in relapsed/refractory myelofibrosis (R/R MF).

The estimated addressable market for imetelstat in these indications is as follows:

  • Geron estimates a total addressable market value of $7 billion by 2031 for imetelstat across hematological diseases such as MDS and MF. This market size is for the U.S. and E.U. markets combined.
  • Specifically, the market opportunity for LR-MDS is estimated at approximately $3.5 billion, and for myelofibrosis, also approximately $3.5 billion. These estimates refer to the U.S. and E.U. markets.

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Geron Corporation (GERN) anticipates several key drivers to fuel its revenue growth over the next 2-3 years, primarily centered around its flagship product, RYTELO (imetelstat).

  1. Increased Adoption and Utilization of RYTELO in the U.S. Market: Geron is focused on enhancing healthcare professional (HCP) awareness and improving the effectiveness of its commercial strategies in the U.S. market to boost RYTELO's adoption. This includes expanding the prescriber base and specifically targeting increased usage in first- and second-line therapies for lower-risk Myelodysplastic Syndromes (MDS). The company aims to drive new patient starts and extend the duration of therapy.
  2. Expansion of RYTELO into European Markets: Having received marketing authorization for RYTELO from the European Commission, Geron plans to expand its commercial strategies into EU markets by 2026. This strategic move represents a significant opportunity to reach a broader patient population and diversify revenue streams.
  3. Potential Approval and Commercialization for Myelofibrosis (MF): Geron's Phase 3 IMpactMF trial evaluating imetelstat for relapsed/refractory myelofibrosis (MF) has completed enrollment by year-end 2025, with an interim analysis expected in the second half of 2026. A successful outcome and subsequent approval for this indication would open a substantial new market, representing a significant expansion opportunity beyond lower-risk MDS.
  4. Sales Force Expansion and Enhanced Commercial Execution: Geron has been actively investing in and expanding its commercial sales force and medical affairs teams. These efforts are designed to increase brand awareness, provide physician education, and drive deeper market penetration for RYTELO. The company's strategy involves direct engagement with hematologists and treatment centers to support uptake.

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Share Repurchases

Geron has not reported any significant share repurchase programs or actual share repurchases over the last 3-5 years.

Share Issuance

  • In January 2023, Geron completed an underwritten public offering of common stock and pre-funded warrants, generating approximately $213.3 million in net cash proceeds.
  • During 2023, the company received $105.9 million in cash proceeds from the exercise of outstanding warrants.
  • Stockholders approved an increase of 20,000,000 shares for the 2018 Equity Incentive Plan and an additional 6,000,000 shares for the 2014 Employee Stock Purchase Plan in May 2025.

Inbound Investments

  • Geron received net cash proceeds from synthetic royalty and debt financings in November 2024, contributing to a larger marketable securities portfolio.

Outbound Investments

Geron has not reported any significant outbound strategic investments in other companies over the last 3-5 years.

Capital Expenditures

  • Capital expenditures amounted to approximately $0.4 million in 2020, $0.21 million in 2021, $0.43 million in 2022, $0.83 million in 2023, and $0.68 million in 2024.

Better Bets than Geron (GERN)

Trade Ideas

Select ideas related to GERN. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
21.4%21.4%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.4%-7.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
18.0%18.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.9%3.9%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
12.2%12.2%-5.1%

Recent Active Movers

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Peer Comparisons for Geron

Peers to compare with:

Financials

GERNHPQHPEIBMCSCOAAPLMedian
NameGeron HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Price1.3723.2624.49305.0978.16273.4051.32
Mkt Cap0.921.932.6284.9309.24,074.4158.8
Rev LTM18355,29534,29665,40257,696408,62556,496
Op Inc LTM-633,6241,64411,54412,991130,2147,584
FCF LTM-1332,80062711,85412,73396,1847,327
FCF 3Y Avg-1712,9781,40011,75313,879100,5037,366
CFO LTM-1333,6972,91913,48313,744108,5658,590
CFO 3Y Avg-1703,6723,89613,49814,736111,5598,697

Growth & Margins

GERNHPQHPEIBMCSCOAAPLMedian
NameGeron HP Hewlett .Internat.Cisco Sy.Apple  
Rev Chg LTM522.1%3.2%13.8%4.5%8.9%6.0%7.4%
Rev Chg 3Y Avg3,214.2%-3.9%6.5%2.6%3.7%1.8%3.2%
Rev Chg Q67.1%4.2%14.4%9.1%7.5%9.6%9.4%
QoQ Delta Rev Chg LTM11.5%1.1%3.7%2.1%1.8%2.1%2.1%
Op Mgn LTM-34.4%6.6%4.8%17.7%22.5%31.9%12.1%
Op Mgn 3Y Avg-19,342.9%7.4%7.2%16.4%24.2%30.8%11.9%
QoQ Delta Op Mgn LTM12.7%-0.2%-1.4%0.6%0.4%0.1%0.2%
CFO/Rev LTM-72.5%6.7%8.5%20.6%23.8%26.6%14.6%
CFO/Rev 3Y Avg-17,301.2%6.8%12.7%21.4%26.1%28.4%17.1%
FCF/Rev LTM-72.5%5.1%1.8%18.1%22.1%23.5%11.6%
FCF/Rev 3Y Avg-17,397.4%5.5%4.6%18.6%24.6%25.6%12.1%

Valuation

GERNHPQHPEIBMCSCOAAPLMedian
NameGeron HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Cap0.921.932.6284.9309.24,074.4158.8
P/S5.00.41.04.45.410.04.7
P/EBIT-19.96.819.925.122.531.321.2
P/E-11.48.6572.736.029.941.033.0
P/CFO-6.95.911.221.122.537.516.2
Total Yield-8.8%14.1%2.3%5.0%5.4%2.8%3.9%
Dividend Yield0.0%2.5%2.1%2.2%2.1%0.4%2.1%
FCF Yield 3Y Avg-11.7%10.6%5.5%6.4%6.0%3.1%5.7%
D/E0.10.50.70.20.10.00.2
Net D/E-0.30.30.60.20.00.00.1

Returns

GERNHPQHPEIBMCSCOAAPLMedian
NameGeron HP Hewlett .Internat.Cisco Sy.Apple  
1M Rtn15.1%-1.8%14.4%0.6%2.7%-1.5%1.7%
3M Rtn6.2%-11.9%2.7%7.9%17.0%7.1%6.7%
6M Rtn-8.1%-4.0%34.5%6.6%15.2%36.3%10.9%
12M Rtn-59.1%-27.0%16.2%40.5%34.5%7.5%11.8%
3Y Rtn-33.8%-1.9%71.1%143.1%81.3%120.2%76.2%
1M Excs Rtn15.7%-5.6%12.9%-2.2%-0.0%-3.7%-1.1%
3M Excs Rtn1.9%-16.2%-1.7%3.6%12.7%2.8%2.4%
6M Excs Rtn-20.3%-16.3%22.3%-5.7%3.0%24.0%-1.3%
12M Excs Rtn-75.0%-42.9%-0.7%25.0%19.9%-8.4%-4.6%
3Y Excs Rtn-114.2%-83.5%-11.2%59.6%-1.2%28.4%-6.2%

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA217779  RYTELOimetelstat sodiumpowder606202410.0%2.3%-58.9%-64.8%-64.8%

Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Development of therapeutic products for oncology01100
Total01100


Price Behavior

Price Behavior
Market Price$1.37 
Market Cap ($ Bil)0.9 
First Trading Date07/31/1996 
Distance from 52W High-61.9% 
   50 Days200 Days
DMA Price$1.23$1.37
DMA Trenddowndown
Distance from DMA11.0%-0.2%
 3M1YR
Volatility57.3%71.1%
Downside Capture215.68189.28
Upside Capture202.1471.02
Correlation (SPY)39.1%30.2%
GERN Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta2.181.931.701.901.081.12
Up Beta4.503.553.423.031.140.97
Down Beta0.811.391.280.780.861.51
Up Capture144%99%69%128%25%57%
Bmk +ve Days12253873141426
Stock +ve Days8172755101331
Down Capture191%205%184%227%137%106%
Bmk -ve Days7162452107323
Stock -ve Days10213063132376

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of GERN With Other Asset Classes (Last 1Y)
 GERNSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-60.7%15.1%17.8%72.1%8.6%4.4%-8.2%
Annualized Volatility70.7%17.2%19.4%19.3%15.2%17.0%35.0%
Sharpe Ratio-1.010.650.722.700.340.09-0.08
Correlation With Other Assets 32.7%30.1%0.4%6.5%25.1%19.6%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
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Based On 5-Year Data
 Comparison of GERN With Other Asset Classes (Last 5Y)
 GERNSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-4.8%8.4%14.7%18.7%11.5%4.6%30.8%
Annualized Volatility81.8%14.5%17.1%15.5%18.7%18.9%48.6%
Sharpe Ratio0.270.400.700.970.500.160.57
Correlation With Other Assets 19.3%24.0%4.4%5.9%22.3%12.6%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of GERN With Other Asset Classes (Last 10Y)
 GERNSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-11.7%9.9%14.8%15.3%7.0%5.3%69.2%
Annualized Volatility78.0%16.6%18.0%14.7%17.6%20.8%55.8%
Sharpe Ratio0.190.490.710.860.320.220.90
Correlation With Other Assets 23.0%24.4%2.2%10.3%17.6%8.6%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date12152025
Short Interest: Shares Quantity76,015,555
Short Interest: % Change Since 11302025-1.8%
Average Daily Volume7,413,805
Days-to-Cover Short Interest10.25
Basic Shares Quantity667,101,756
Short % of Basic Shares11.4%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/5/2025-5.2%8.7%13.9%
8/6/202515.8%12.5%15.0%
5/7/2025-0.8%-9.1%18.2%
2/26/2025-32.1%-30.0%-28.3%
11/7/20240.5%-9.4%-8.0%
8/8/20240.9%-2.6%-6.8%
5/2/2024-3.2%-6.6%-13.0%
11/2/2023-7.8%-4.1%3.1%
...
SUMMARY STATS   
# Positive7911
# Negative13119
Median Positive3.1%6.6%13.9%
Median Negative-4.5%-7.4%-16.0%
Max Positive15.8%12.5%43.6%
Max Negative-32.1%-30.0%-28.3%

SEC Filings

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Report DateFiling DateFiling
93020251107202510-Q 9/30/2025
6302025806202510-Q 6/30/2025
3312025507202510-Q 3/31/2025
12312024227202510-K 12/31/2024
93020241107202410-Q 9/30/2024
6302024808202410-Q 6/30/2024
3312024502202410-Q 3/31/2024
12312023228202410-K 12/31/2023
93020231102202310-Q 9/30/2023
6302023803202310-Q 6/30/2023
3312023511202310-Q 3/31/2023
12312022316202310-K 12/31/2022
93020221107202210-Q 9/30/2022
6302022811202210-Q 6/30/2022
3312022509202210-Q 3/31/2022
12312021310202210-K 12/31/2021