Vanda Pharmaceuticals (VNDA)


Market Price (11/8/2026): $3.805 | Market Cap: $230.1 MilSector: Health Care | Industry: Biotechnology

Vanda Pharmaceuticals (VNDA)


Market Price (11/8/2026): $3.805
Market Cap: $230.1 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -51%

Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -41%

Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.

Weak multi-year price returns
2Y Excs Rtn is -47%, 3Y Excs Rtn is -87%

Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -178 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -78%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -61%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -65%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -124%

Key risks
VNDA key risks include [1] significant financial distress, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -51%
1 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -41%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -47%, 3Y Excs Rtn is -87%
4 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -178 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -78%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -61%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -65%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -124%
8 Key risks
VNDA key risks include [1] significant financial distress, Show more.

VNDA in ETFs

Weight = VNDA's share of each fund

VTI0.00%
ITOT0.00%
IWM0.01%
XBI0.07%
IBB0.01%
IWN0.01%
VTWO0.01%
SCHA0.01%
+5 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

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Updated on 11/1/2026

Vanda Pharmaceuticals (VNDA) stock has lost about 25% since 7/31/2026 because of the following key factors:

1. Failed Phase III Clinical Trial for VQW-765.

Vanda Pharmaceuticals announced on October 14, 2026, that its Phase III clinical study of VQW-765, an investigational treatment for acute anxiety in adults with social anxiety disorder, did not meet its primary endpoint. This significant pipeline setback led to the program being put on hold and indicated a loss of potential future revenue from this drug candidate. The study showed no statistically significant difference in distress levels between participants receiving VQW-765 and those on placebo.

2. Erosion of HETLIOZ Market Share Due to Patent Litigation and Generic Competition.

In September 2026, the Delaware District Court ruled against Vanda in patent litigation, finding non-infringement of HETLIOZ patents by generic manufacturers Teva and Apotex. This legal defeat exacerbated the impact of generic competition, which contributed to HETLIOZ net product sales decreasing by 21% to $43.2 million in the first nine months of fiscal 2026, compared to $55.0 million in the same period of fiscal 2025.

Show more
Updated on 11/1/2026

Vanda Pharmaceuticals (VNDA) stock has lost about 25% since 7/31/2026 because of the following key factors:

1. Failed Phase III Clinical Trial for VQW-765.

Vanda Pharmaceuticals announced on October 14, 2026, that its Phase III clinical study of VQW-765, an investigational treatment for acute anxiety in adults with social anxiety disorder, did not meet its primary endpoint. This significant pipeline setback led to the program being put on hold and indicated a loss of potential future revenue from this drug candidate. The study showed no statistically significant difference in distress levels between participants receiving VQW-765 and those on placebo.

2. Erosion of HETLIOZ Market Share Due to Patent Litigation and Generic Competition.

In September 2026, the Delaware District Court ruled against Vanda in patent litigation, finding non-infringement of HETLIOZ patents by generic manufacturers Teva and Apotex. This legal defeat exacerbated the impact of generic competition, which contributed to HETLIOZ net product sales decreasing by 21% to $43.2 million in the first nine months of fiscal 2026, compared to $55.0 million in the same period of fiscal 2025.

3. Department of Justice Investigation into False Claims Act Violations.

In October 2026, Vanda disclosed that the Department of Justice (DOJ) was considering a civil complaint as part of an investigation into possible False Claims Act violations. This ongoing investigation introduces significant regulatory uncertainty and potential legal and financial liabilities for the company, contributing to investor apprehension.

4. Sustained Cash Burn and Widening Net Losses.

Vanda Pharmaceuticals continued to experience substantial financial outflows, with its cash, cash equivalents, and marketable securities decreasing by $123.4 million from December 31, 2025, to $140.5 million as of September 30, 2026. The company reported a net loss of $62.5 million in fiscal Q2 2026, missing consensus EPS estimates by $0.46. Although the net loss narrowed slightly in fiscal Q3 2026 to $22.6 million from $28.4 million in Q3 2025, the continued cash depletion and overall unprofitability across the specified period raised concerns about the company's financial health.

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Stock Movement Drivers

Fundamental Drivers

The -25.1% change in VNDA stock from 7/31/2026 to 11/7/2026 was primarily driven by a -27.7% change in the company's P/S Multiple.
(LTM values as of)731202611072026Change
Stock Price ($)5.103.82-25.1%
Change Contribution By: 
Total Revenues ($ Mil)2182295.3%
P/S Multiple1.41.0-27.7%
Shares Outstanding (Mil)5960-1.7%
Cumulative Contribution-25.1%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2026 to 11/7/2026
ReturnCorrelation
VNDA-25.1% 
Market (SPY)-1.6%40.7%
Sector (XLV)13.7%37.4%

Fundamental Drivers

The -46.2% change in VNDA stock from 4/30/2026 to 11/7/2026 was primarily driven by a -48.1% change in the company's P/S Multiple.
(LTM values as of)430202611072026Change
Stock Price ($)7.103.82-46.2%
Change Contribution By: 
Total Revenues ($ Mil)2162296.1%
P/S Multiple1.91.0-48.1%
Shares Outstanding (Mil)5960-2.3%
Cumulative Contribution-46.2%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 11/7/2026
ReturnCorrelation
VNDA-46.2% 
Market (SPY)2.6%26.9%
Sector (XLV)27.1%27.5%

Fundamental Drivers

The -12.2% change in VNDA stock from 10/31/2025 to 11/7/2026 was primarily driven by a -16.9% change in the company's P/S Multiple.
(LTM values as of)1031202511072026Change
Stock Price ($)4.353.82-12.2%
Change Contribution By: 
Total Revenues ($ Mil)2122298.1%
P/S Multiple1.21.0-16.9%
Shares Outstanding (Mil)5960-2.3%
Cumulative Contribution-12.2%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 11/7/2026
ReturnCorrelation
VNDA-12.2% 
Market (SPY)8.7%13.0%
Sector (XLV)29.8%21.6%

Fundamental Drivers

The -12.8% change in VNDA stock from 10/31/2023 to 11/7/2026 was primarily driven by a -5.0% change in the company's Shares Outstanding (Mil).
(LTM values as of)1031202311072026Change
Stock Price ($)4.383.82-12.8%
Change Contribution By: 
Total Revenues ($ Mil)238229-3.8%
P/S Multiple1.11.0-4.6%
Shares Outstanding (Mil)5760-5.0%
Cumulative Contribution-12.8%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2023 to 11/7/2026
ReturnCorrelation
VNDA-12.8% 
Market (SPY)81.9%16.5%
Sector (XLV)55.4%25.3%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
VNDA Return19%-53%-43%14%84%-57%-71%
Peers Return-25%33%9%-5%42%-1%46%
S&P 500 Return27%-19%24%23%16%12%105%

Monthly Win Rates [3]
VNDA Win Rate58%25%42%50%50%36% 
Peers Win Rate48%58%50%50%62%45% 
S&P 500 Win Rate75%42%67%75%67%45% 

Max Drawdowns [4]
VNDA Max Drawdown-29%-58%-58%-32%-24%-62% 
Peers Max Drawdown-50%-38%-39%-32%-34%-34% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: NBIX, ACAD, AXSM, HRMY, JAZZ.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 11/6/2026 (YTD)

How Low Can It Go

EventVNDAS&P 500
2025 US Tariff Shock
  % Loss-13.8%-18.8%
  % Gain to Breakeven16.1%23.1%
  Time to Breakeven23 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-47.2%-9.5%
  % Gain to Breakeven89.3%10.5%
  Time to Breakeven217 days24 days
2023 SVB Regional Banking Crisis
  % Loss-18.3%-6.7%
  % Gain to Breakeven22.4%7.1%
  Time to Breakeven944 days31 days
2020 COVID-19 Crash
  % Loss-44.2%-33.7%
  % Gain to Breakeven79.3%50.9%
  Time to Breakeven259 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-16.9%-19.2%
  % Gain to Breakeven20.4%23.8%
  Time to Breakeven8 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-21.9%-3.7%
  % Gain to Breakeven28.0%3.9%
  Time to Breakeven161 days6 days

Compare to NBIX, ACAD, SUPN, AXSM, HRMY

In The Past

Vanda Pharmaceuticals's stock fell -13.8% during the 2025 US Tariff Shock. Such a loss loss requires a 16.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventVNDAS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-47.2%-9.5%
  % Gain to Breakeven89.3%10.5%
  Time to Breakeven217 days24 days
2020 COVID-19 Crash
  % Loss-44.2%-33.7%
  % Gain to Breakeven79.3%50.9%
  Time to Breakeven259 days140 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-21.9%-3.7%
  % Gain to Breakeven28.0%3.9%
  Time to Breakeven161 days6 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-41.2%-12.2%
  % Gain to Breakeven70.1%13.9%
  Time to Breakeven142 days62 days
2014-2016 Oil Price Collapse
  % Loss-39.4%-6.8%
  % Gain to Breakeven65.1%7.3%
  Time to Breakeven183 days15 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-33.7%-17.9%
  % Gain to Breakeven50.8%21.8%
  Time to Breakeven599 days123 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-37.0%-15.4%
  % Gain to Breakeven58.6%18.2%
  Time to Breakeven158 days125 days
2008-2009 Global Financial Crisis
  % Loss-92.9%-53.4%
  % Gain to Breakeven1300.0%114.4%
  Time to Breakeven127 days1085 days
Summer 2007 Credit Crunch
  % Loss-33.2%-8.6%
  % Gain to Breakeven49.6%9.5%
  Time to Breakeven3968 days47 days

Compare to NBIX, ACAD, SUPN, AXSM, HRMY

In The Past

Vanda Pharmaceuticals's stock fell -13.8% during the 2025 US Tariff Shock. Such a loss loss requires a 16.1% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Vanda Pharmaceuticals (VNDA)

Vanda Pharmaceuticals Inc. is a biopharmaceutical company focused on developing and commercializing treatments for conditions with high unmet medical needs. The company's main marketed products include HETLIOZ, prescribed for non-24-hour sleep-wake disorder, and Fanapt oral tablets, used in the treatment of schizophrenia. These products address significant neurological and psychiatric conditions in the market.

The company maintains an active pipeline, exploring new applications for its existing drugs and advancing novel therapies. HETLIOZ is under development for a wider range of sleep-related conditions, such as jet lag disorder and sleep disturbances associated with Smith-Magenis syndrome and autism. Fanapt is being investigated for bipolar disorder and as a long-acting injectable formulation for schizophrenia. Additionally, Vanda is developing Tradipitant, a small molecule neurokinin-1 receptor antagonist, for diverse indications including atopic dermatitis, gastroparesis, and motion sickness, showcasing its reach into inflammatory and gastrointestinal areas.

Vanda Pharmaceuticals primarily serves patients suffering from specific sleep disorders, psychiatric conditions like schizophrenia and bipolar disorder, and potential future indications such as atopic dermatitis and gastroparesis. The company markets and develops its therapies in key regions, including the United States, Europe, and Israel, aiming to provide solutions in these specialized medical fields.

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  • Acadia Pharmaceuticals for sleep and broader psychiatric disorders.
  • Vertex Pharmaceuticals, but focused on neurological and sleep disorders instead of cystic fibrosis.

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  • HETLIOZ: A marketed therapy for the treatment of non-24-hour sleep-wake disorders.
  • Fanapt: Marketed oral tablets for the treatment of schizophrenia.
  • Tradipitant (VLY-686): A small molecule neurokinin-1 receptor antagonist in development for atopic dermatitis, gastroparesis, and motion sickness.
  • VTR-297: A small molecule histone deacetylase inhibitor under development for hematologic malignancies and other oncology indications.
  • VQW-765: A small molecule nicotinic acetylcholine receptor partial agonist being developed for psychiatric disorders.
  • HETLIOZ (tasimelteon) extended indications: Investigated for new conditions including jet lag disorder, smith-magenis syndrome, and autism spectrum disorders.
  • Fanapt (iloperidone) extended indications/formulations: Explored for new indications such as bipolar disorder and as a long-acting injectable formulation for schizophrenia.

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Vanda Pharmaceuticals Inc. (VNDA) primarily sells its pharmaceutical products to individual patients through the healthcare system.

Its major customer categories are:

  • Individuals diagnosed with non-24-hour sleep-wake disorder, who are prescribed HETLIOZ.
  • Individuals diagnosed with schizophrenia, who are prescribed Fanapt oral tablets.

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Mihael H. Polymeropoulos, MD, President, Chief Executive Officer and Chairman of the Board

Mihael H. Polymeropoulos cofounded Vanda Pharmaceuticals in 2003 and has served as President, Chief Executive Officer, and a Director since May 2003, and as Chairman of the Board since June 2021. Prior to Vanda, he was Vice President and Head of the Pharmacogenetics Department at Novartis AG from 1998 to 2003, and Chief of the Gene Mapping Section at the National Human Genome Research Institute from 1992 to 1998. He is also a cofounder of the Integrated Molecular Analysis of Genome Expression (I.M.A.G.E.) Consortium. Vanda was founded in partnership with Care Capital LLC, a biopharmaceuticals-focused investment firm, and Bio*One Capital, an investment arm of the Singapore government, indicating private equity backing at the company's inception.

Kevin Moran, Senior Vice President, Chief Financial Officer and Treasurer

Kevin Moran has served as Vanda's Senior Vice President, Chief Financial Officer and Treasurer since July 2020. He joined Vanda in September 2010 and held various finance roles, including Controller, Vice President and Controller, and Vice President, Acting Chief Financial Officer and Treasurer, before his current appointment. Before joining Vanda, Mr. Moran was a Senior Associate at PricewaterhouseCoopers. He earned his Bachelor of Business Administration and Master of Science in Accounting from James Madison University.

Gunther Birznieks, Senior Vice President, Business Development

Gunther Birznieks is Vanda's Senior Vice President, Business Development, and a member of the R&D Committee. He has held various positions at Vanda since 2003, including Clinical Program Head of the Hetlioz and VSF-173 programs, Head of Informatics, and Head of Operations in Singapore. Prior to Vanda, Mr. Birznieks founded Extropia Pte Ltd, a Singaporean company focused on business and investment banking applications. His career also includes work in healthcare and biomedical informatics, providing bioinformatics support for the Human Genome Project.

Tim Williams, Senior Vice President, General Counsel and Secretary

Tim Williams has served as Vanda's Senior Vice President, General Counsel, and Secretary since August 2018. Before joining Vanda, he was Executive Vice President, General Counsel, Chief Compliance Officer, and Corporate Secretary at AgNovos Healthcare, a medical device company. Previously, Mr. Williams was Senior Legal Counsel and Assistant Secretary at Stryker Corporation, a global medical technology company, where he led global M&A, corporate governance, and securities groups. He also practiced law at Mayer Brown LLP and Bryan Cave LLP.

Joakim Wijkstrom, Senior Vice President, Chief Marketing Officer

Joakim Wijkstrom, also known as Kim Wijkstrom, has served as Vanda's Senior Vice President, Chief Marketing Officer, since August 2019. Prior to Vanda, he held Chief Marketing Officer positions at Perry Ellis International and OneMain Financial. He also held senior leadership roles at advertising agencies such as TBWA Chiat Day, BBDO, and Crispin Porter + Bogusky, where he developed marketing strategies for various clients including Apple and Volkswagen. Mr. Wijkstrom holds a BA in Art History from Georgetown University and an MBA in Marketing from New York University.

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Key Risks to Vanda Pharmaceuticals (VNDA):

  1. Clinical Development and Regulatory Approval Risk: Vanda Pharmaceuticals has an extensive pipeline with numerous product candidates and indications under development, including further applications for HETLIOZ and Fanapt, as well as several novel compounds like Tradipitant, VTR-297, and VQW-765. The success of a biopharmaceutical company heavily relies on the successful outcome of costly and lengthy clinical trials and subsequent regulatory approvals. Failures in late-stage clinical trials due to lack of efficacy or safety concerns, or an inability to obtain regulatory marketing authorization, would significantly impact the company's future growth and financial performance, as a substantial portion of its future value is tied to the successful commercialization of these pipeline assets.
  2. Reliance on a Limited Number of Marketed Products: Vanda Pharmaceuticals currently generates revenue primarily from two marketed products: HETLIOZ for non-24-hour sleep-wake disorders and Fanapt oral tablets for schizophrenia. Any significant adverse events, unexpected safety concerns, manufacturing issues, or changes in reimbursement policies affecting these two products could severely impact the company's revenue stream and profitability, given its current dependence on them.
  3. Intense Competition for Marketed Products: Both the sleep disorder and schizophrenia markets are competitive. HETLIOZ, while addressing a niche disorder, and Fanapt face competition from existing treatments, and potential new entrants could further intensify this landscape. Competitive pressures, including the introduction of new, more effective, or lower-cost therapies, could lead to reduced market share, pricing pressure, and decreased demand for Vanda's current commercialized products.

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Addressable Markets for Vanda Pharmaceuticals' Main Products

For Vanda Pharmaceuticals' key products and their indications, the addressable market sizes are as follows:

HETLIOZ (tasimelteon)

  • Non-24-hour sleep-wake disorders: The global market size was valued at USD 1.5 billion in 2024 and is expected to reach USD 3.2 billion by 2032.
  • Smith-Magenis syndrome: The global market size was valued at USD 120 million in 2024 and is expected to reach USD 192.71 million by 2032.
  • Delayed sleep phase disorder: This falls under the global circadian rhythm sleep treatment market, which is valued at US$ 2.4 billion in 2025 and is projected to reach US$ 3.7 billion by 2032.
  • Jet lag disorder: This is part of the global circadian rhythm sleep treatment market, estimated at US$ 784.7 million in 2024 and projected to reach US$ 1.23 billion by the end of 2034.
  • Pediatric Non-24: null
  • Autism spectrum (sleep-related): null

Fanapt (iloperidone)

  • Schizophrenia: The global market size was estimated at USD 8.36 billion in 2024 and is expected to reach USD 12.78 billion by 2032. The U.S. market was valued at USD 2.84 billion in 2024 and is projected to reach USD 4.31 billion by 2032.
  • Bipolar disorder: The global market size was valued at USD 5.7 billion in 2024 and is projected to grow to USD 8.2 billion by 2034. The U.S. market is projected to reach USD 3.5 billion by 2034.

Tradipitant (VLY-686)

  • Atopic dermatitis: The global market size was estimated at USD 17.64 billion in 2024 and is projected to reach USD 29.88 billion by 2030. The U.S. market generated a revenue of USD 6,405.7 million in 2024 and is expected to reach USD 9,991.8 million by 2030.
  • Gastroparesis: The global market size was valued at USD 6.82 billion in 2024 and is expected to reach USD 9.89 billion by 2032. The U.S. gastroparesis treatment market size was exhibited at USD 1.95 billion in 2024 and is projected to be worth around USD 3.13 billion by 2034.
  • Motion sickness: The global motion sickness treatment market size was USD 719.69 million in 2024 and is projected to reach USD 922.53 million by 2032.

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Here are the expected drivers of future revenue growth for Vanda Pharmaceuticals (VNDA) over the next 2-3 years:

  1. Expanded Market Penetration and Indications for Fanapt: Vanda Pharmaceuticals anticipates continued revenue growth from Fanapt (iloperidone) through increased market penetration in its approved indications of schizophrenia and, notably, bipolar I disorder, for which it launched in April 2024. This growth is evidenced by a 24% increase in full-year 2025 net product sales, driven by a 28% rise in total prescriptions and a significant 149% surge in new-to-brand prescriptions. Strategic sales and marketing efforts, including direct-to-consumer campaigns, are expected to further enhance brand awareness and prescriber engagement, contributing an estimated $150-$170 million in 2026.
  2. Launch of Bysanti (milsaperidone): The recent FDA approval of BYSANTI (milsaperidone) for the treatment of bipolar I disorder and schizophrenia, announced in February 2026, is a key driver for future revenue. With a PDUFA target action date of February 21, 2026, and an anticipated launch in Q3 2026, Bysanti benefits from expected long-term market exclusivity extending to 2044, providing a sustained revenue stream.
  3. Launch and Pipeline Expansion of NEREUS (tradipitant): The approval of NEREUS (tradipitant) for the prevention of vomiting induced by motion, with a PDUFA date of December 30, 2025, and a potential launch by mid-2026, presents a new commercial opportunity. Furthermore, Vanda plans to initiate a Phase 3 program in the first half of 2026 for NEREUS's use in preventing vomiting from GLP-1 analogs, with results expected by the end of 2026. Positive clinical results in this area indicate significant potential for enhanced compliance and demand in the growing obesity treatment market.
  4. Commercialization of PONVORY: The acquisition of PONVORY in Q4 2023 and its subsequent successful commercial launch for multiple sclerosis are expected to contribute to revenue growth. The product has seen increased patient demand throughout 2025 and is projected to contribute to the combined $80-$90 million in revenue from HETLIOZ and PONVORY in 2026.

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Capital Allocation Decisions (Last 3-5 Years)

Share Repurchases

  • Vanda Pharmaceuticals repurchased $0.92 million in common stock in fiscal year 2025.
  • No significant share repurchases were reported for fiscal years 2021, 2022, 2023, or 2024.

Share Issuance

  • The company issued $3.55 million in common stock in fiscal year 2021.
  • Vanda Pharmaceuticals issued $0.73 million in common stock in fiscal year 2022.
  • In February 2026, Vanda Pharmaceuticals filed a shelf registration to offer up to $200 million in various securities, including common stock, for future capital raising.

Outbound Investments

  • Vanda Pharmaceuticals made a significant investment in intangible assets, amounting to $100.67 million, in fiscal year 2023.
  • The company purchased $4.23 million in intangible assets in fiscal year 2024.

Capital Expenditures

  • Annual capital expenditures were $0.55 million in fiscal year 2021, $0.68 million in fiscal year 2022, $0.38 million in fiscal year 2023, $0.49 million in fiscal year 2024, and $1 million in fiscal year 2025.
  • These expenditures are typically focused on maintaining and upgrading operational infrastructure, such as laboratory equipment and information technology.

Better Bets vs. Vanda Pharmaceuticals (VNDA)

Peer Outperformance in Biotechnology

VNDA has outperformed 53% of its 364 Biotechnology peers over 5Y. Among the peers that beat it are GILD, ABBV and BIIB. Biotechnology ranks 9th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that VNDA has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
54%
of 452 industry peers · -13.2% return
3Y
57%
of 398 industry peers · -11.8% return
5Y
53%
of 364 industry peers · -78.7% return
Biotechnology peers with revenue growth within 4pp of VNDA's that beat it on at least 2 of 3 windows, and by at least 20pp over 5Y. Growth is matched by construction, so the gap is largely a re-rating gap. The multiple column is the context for it.
Ticker Name Rev Growth 3Y Avg P/E 1Y3Y5Y 5Y Gap
VNDA Vanda Pharmaceuticals 3.1% -0.8x -13.2%-11.8%-78.7% —
GILD Gilead Sciences 4.2% -53.7x 43.9%135.5%200.7% +279pp
ABBV AbbVie 6.3% 49.8x 36.9%126.6%196.9% +276pp
BIIB Biogen 1.1% 105.6x 59.7%7.2%-10.9% +68pp
Price returns, excluding dividends. P/E shown for context only and not used for matching.
Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is VNDA's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 6.4%54.7%91.6% CAH 507% · MCK 390% · COR 176%
Health Care Services 20 32.4%24.2%7.1% HIMS 212% · RDNT 120% · DGX 100%
Managed Health Care 8 55.2%-1.0%-2.4% OSCR 80% · HQY 52% · ELV 8%
Health Care Facilities 26 16.4%19.8%-6.8% THC 276% · NHC 212% · EHC 179%
Health Care Equipment 50 4.0%12.4%-18.2% UFPT 361% · GKOS 294% · TMDX 180%
Pharmaceuticals 61 -8.8%11.8%-37.3% LQDA 975% · XERS 679% · KNSA 537%
Health Care Supplies 11 23.1%16.0%-41.2% LNTH 248% · HAE 61% · MMSI 26%
Life Sciences Tools & Services 108 -6.4%-14.3%-74.5% AXGN 264% · MEDP 189% · NTRA 168%
Biotechnology ← 365 -23.8%-33.1%-81.5% ELVN 1194% · TRVI 1125% · DNTH 995%
Health Care Technology 21 -21.7%-51.6%-82.9% VEEV -5% · DOCS -52%
Median of constituents with a full price history over each window. Top names are limited to companies above $2B market cap.

Latest Trefis Analyses

Title
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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

VNDANBIXACADAXSMHRMYJAZZMedian
NameVanda Ph.Neurocri.Acadia P.Axsome T.Harmony .Jazz Pha. 
Mkt Price3.81164.6421.23132.3733.12234.6882.74
Mkt Cap0.216.73.76.91.915.25.3
Rev LTM2293,7021,2028659894,7181,096
Op Inc LTM-178910122-1632191,134171
FCF LTM-1501,03786-833231,414204
FCF 3Y Avg-8469096-1062801,252188
CFO LTM-1391,06698-823231,692210
CFO 3Y Avg-80726166-1052811,416223

Growth & Margins

VNDANBIXACADAXSMHRMYJAZZMedian
NameVanda Ph.Neurocri.Acadia P.Axsome T.Harmony .Jazz Pha. 
Rev Chg LTM8.1%38.0%14.8%54.2%19.8%13.5%17.3%
Rev Chg 3Y Avg3.1%27.8%24.9%57.2%22.2%7.6%23.6%
Rev Chg Q24.1%41.2%22.8%51.9%12.3%10.4%23.5%
QoQ Delta Rev Chg LTM6.3%9.7%5.6%11.4%3.1%2.5%5.9%
Op Inc Chg LTM-46.9%64.4%29.6%16.1%-2.8%149.9%22.9%
Op Inc Chg 3Y Avg-5,511.6%42.5%62.1%1.0%4.6%45.3%23.6%
Op Mgn LTM-77.6%24.6%10.2%-18.9%22.2%24.0%16.2%
Op Mgn 3Y Avg-51.4%23.8%10.4%-42.1%25.1%17.3%13.9%
QoQ Delta Op Mgn LTM8.5%0.7%2.6%4.7%-1.9%4.6%3.6%
CFO/Rev LTM-60.7%28.8%8.1%-9.5%32.7%35.9%18.5%
CFO/Rev 3Y Avg-36.2%24.6%16.3%-22.2%33.7%32.8%20.4%
FCF/Rev LTM-65.4%28.0%7.2%-9.5%32.6%30.0%17.6%
FCF/Rev 3Y Avg-38.0%23.3%9.7%-22.3%33.6%29.1%16.5%

Valuation

VNDANBIXACADAXSMHRMYJAZZMedian
NameVanda Ph.Neurocri.Acadia P.Axsome T.Harmony .Jazz Pha. 
Mkt Cap0.216.73.76.91.915.25.3
P/S1.04.53.08.02.03.23.1
P/Op Inc-1.318.429.9-42.58.813.411.1
P/EBIT-1.320.829.9-46.07.935.514.3
P/E-0.823.810.1-44.110.873.710.5
P/CFO-1.715.737.5-84.96.09.07.5
Total Yield-119.0%4.2%9.9%-2.3%9.2%1.4%2.8%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-28.4%5.1%3.5%-1.9%14.2%13.7%4.3%
D/E0.10.00.00.00.10.40.1
Net D/E-0.5-0.0-0.2-0.0-0.30.2-0.1

Returns

VNDANBIXACADAXSMHRMYJAZZMedian
NameVanda Ph.Neurocri.Acadia P.Axsome T.Harmony .Jazz Pha. 
1M Rtn-16.0%16.6%8.4%-22.2%-16.4%5.5%-5.3%
3M Rtn-23.9%0.8%-27.3%-37.8%-13.8%-8.5%-18.8%
6M Rtn-39.4%8.1%-5.2%-39.1%6.9%3.9%-0.7%
12M Rtn-13.5%8.1%-6.0%-4.2%5.4%78.9%0.6%
3Y Rtn-12.1%42.7%-8.5%115.0%38.4%83.0%40.5%
1M Excs Rtn-11.0%21.6%13.4%-17.2%-11.4%10.5%-0.3%
3M Excs Rtn-19.4%4.7%-22.9%-35.2%-10.2%-3.7%-14.8%
6M Excs Rtn-39.1%8.4%-4.9%-38.8%7.2%4.2%-0.4%
12M Excs Rtn-22.8%-1.5%-13.5%-11.0%-2.9%62.5%-7.0%
3Y Excs Rtn-86.7%-26.5%-81.4%30.8%-39.0%10.2%-32.7%

Comparison Analyses

null

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA220358  BYSANTImilsaperidonetablet22020267.5%-8.3%-33.7%-33.7%-33.7%
NDA220152  NEREUStradipitantcapsule12302025-1.7%-12.9%-45.7%-45.7%-45.7%
NDA213498  PONVORYponesimodtablet318202114.7%-4.6%-29.4%-61.7%-77.6%
NDA214517  HETLIOZ LQtasimelteonsuspension1201202045.5%44.3%29.3%-11.2%-69.0%
NDA205677  HETLIOZtasimelteoncapsule13120149.7%6.3%-15.9%-35.5%-71.1%
NDA022192  FANAPTiloperidonetablet50620091,386.1%814.8%650.9%616.7%253.7%
Collapse to Preview
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA220358  BYSANTImilsaperidonetablet22020267.5%-8.3%-33.7%-33.7%-33.7%
NDA220152  NEREUStradipitantcapsule12302025-1.7%-12.9%-45.7%-45.7%-45.7%
NDA213498  PONVORYponesimodtablet318202114.7%-4.6%-29.4%-61.7%-77.6%
NDA214517  HETLIOZ LQtasimelteonsuspension1201202045.5%44.3%29.3%-11.2%-69.0%
NDA205677  HETLIOZtasimelteoncapsule13120149.7%6.3%-15.9%-35.5%-71.1%
NDA022192  FANAPTiloperidonetablet50620091,386.1%814.8%650.9%616.7%253.7%

Clinical Pipeline

Drug CandidateIndicationPhase 3 TrialsEst. Primary Completion
TasimelteonCircadian rhythm sleep disorders and insomnia3Sep 2026
TradipitantGastroparesis, motion sickness, nausea, and COVID-194Dec 2026
VQW-765Social anxiety disorder1Dec 2026
IloperidoneSchizophrenia1Nov 2027
MilsaperidoneMajor depressive disorder1Mar 2028
Ponesimod (VSP-128)Ulcerative colitis and plaque psoriasis2Aug 2028
Active Phase 3 studies led by the company. Source: ClinicalTrials.gov · Updated 8/28/2026

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Fanapt ® net product sales11794919595
HETLIOZ ® net product sales7177100160174
PONVORY ® net product sales2728200
Total216199193254269


Price Behavior

Price Behavior
Market Price$3.82 
Market Cap ($ Bil)0.2 
First Trading Date04/12/2006 
Distance from 52W High-60.0% 
   50 Days200 Days
DMA Price$4.63$6.12
DMA Trenddowndown
Distance from DMA-17.5%-37.5%
 3M1YR
Volatility43.6%79.9%
Downside Capture165.7350.70
Upside Capture52.8927.87
Correlation (S&P 500)39.4%13.2%
VNDA Betas & Captures as of 10/31/2026

 1M2M3M6M1Y3Y
Beta1.090.970.970.680.630.68
Up Beta-3.99-0.270.281.121.170.33
Down Beta1.971.861.941.120.970.91
Up Capture-121%-33%13%-25%25%43%
Bmk +ve Days12182862130427
Stock +ve Days9213459122340
Down Capture253%221%180%127%66%100%
Bmk -ve Days10253664121325
Stock -ve Days13223066126389

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA-14.0%79.9%0.13-
Sector ETF (XLV)28.6%16.9%1.3121.6%
Equity (SPY)9.5%13.6%0.4012.7%
Gold (GLD)1.6%28.7%0.0519.1%
Commodities (DBC)38.4%21.2%1.42-5.0%
Real Estate (VNQ)11.3%14.2%0.517.5%
Bitcoin (BTCUSD)-27.2%43.6%-0.615.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA-25.9%60.7%-0.26-
Sector ETF (XLV)8.3%15.4%0.3526.6%
Equity (SPY)11.3%17.3%0.4819.8%
Gold (GLD)17.5%19.1%0.747.9%
Commodities (DBC)8.1%19.6%0.30-1.6%
Real Estate (VNQ)1.3%18.9%-0.0420.7%
Bitcoin (BTCUSD)4.0%51.6%0.2610.5%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA-12.8%55.4%-0.03-
Sector ETF (XLV)12.2%16.8%0.5930.9%
Equity (SPY)15.0%18.0%0.7027.3%
Gold (GLD)11.9%16.5%0.596.4%
Commodities (DBC)7.5%18.1%0.336.5%
Real Estate (VNQ)5.9%20.7%0.2423.3%
Bitcoin (BTCUSD)60.0%66.3%1.007.9%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date10152026
Short Interest: Shares Quantity8.3 Mil
Short Interest: % Change Since 93020266.1%
Average Daily Volume1.0 Mil
Days-to-Cover Short Interest8.3 days
Basic Shares Quantity60.5 Mil
Short % of Basic Shares13.7%

Earnings Returns History

Updated 11/6/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/28/20261.2%-3.0% 
8/5/20260.5%2.0%4.9%
5/6/2026-14.1%-13.6%-19.0%
2/11/2026-17.6%-17.9%18.6%
10/29/2025-20.1%-17.9%-7.2%
7/31/2025-8.8%-9.6%0.6%
5/7/2025-3.7%-10.5%5.3%
2/13/2025-6.0%-5.7%8.1%
...
SUMMARY STATS   
# Positive8812
# Negative161611
Median Positive4.1%6.7%6.1%
Median Negative-7.3%-11.8%-13.2%
Max Positive21.2%20.0%18.6%
Max Negative-21.9%-18.4%-23.3%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/28/20261.2%-3.0% 
8/5/20260.5%2.0%4.9%
5/6/2026-14.1%-13.6%-19.0%
2/11/2026-17.6%-17.9%18.6%
10/29/2025-20.1%-17.9%-7.2%
7/31/2025-8.8%-9.6%0.6%
5/7/2025-3.7%-10.5%5.3%
2/13/2025-6.0%-5.7%8.1%
11/6/20242.7%11.7%-1.0%
7/31/2024-3.4%-11.0%-10.6%
5/8/2024-6.5%0.0%14.2%
2/7/202411.8%16.8%6.3%
11/8/2023-21.9%-18.0%-13.2%
7/27/2023-8.0%-12.7%-13.6%
5/3/20237.5%6.1%-5.2%
2/8/20230.8%-2.2%-13.3%
11/2/2022-1.7%1.1%5.8%
8/3/2022-4.6%-2.3%0.1%
5/5/2022-2.0%-0.5%1.7%
2/23/2022-2.6%-14.8%-11.0%
11/3/2021-14.0%-15.6%-23.3%
7/28/2021-8.5%-18.4%-14.8%
5/5/20215.6%7.4%9.2%
2/10/202121.2%20.0%16.2%
SUMMARY STATS   
# Positive8812
# Negative161611
Median Positive4.1%6.7%6.1%
Median Negative-7.3%-11.8%-13.2%
Max Positive21.2%20.0%18.6%
Max Negative-21.9%-18.4%-23.3%

SEC Filings

Expand for More
Report DateFiling DateFiling
09/30/202610/29/202610-Q
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202502/12/202610-K
09/30/202510/30/202510-Q
06/30/202507/31/202510-Q
03/31/202505/08/202510-Q
12/31/202402/14/202510-K
09/30/202411/07/202410-Q
06/30/202408/01/202410-Q
03/31/202405/09/202410-Q
12/31/202302/08/202410-K
09/30/202311/09/202310-Q
06/30/202307/28/202310-Q
03/31/202305/03/202310-Q
12/31/202202/09/202310-K
Collapse to Preview
Report DateFiling DateFiling
09/30/202610/29/202610-Q
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202502/12/202610-K
09/30/202510/30/202510-Q
06/30/202507/31/202510-Q
03/31/202505/08/202510-Q
12/31/202402/14/202510-K
09/30/202411/07/202410-Q
06/30/202408/01/202410-Q
03/31/202405/09/202410-Q
12/31/202302/08/202410-K
09/30/202311/09/202310-Q
06/30/202307/28/202310-Q
03/31/202305/03/202310-Q
12/31/202202/09/202310-K
09/30/202211/03/202210-Q
06/30/202208/04/202210-Q
03/31/202205/06/202210-Q
12/31/202102/24/202210-K
09/30/202111/04/202110-Q
06/30/202107/29/202110-Q
03/31/202105/06/202110-Q
12/31/202002/11/202110-K
09/30/202010/29/202010-Q
06/30/202008/06/202010-Q
03/31/202005/07/202010-Q
12/31/201902/26/202010-K

Recent Forward Guidance

Updated 11/2/2026

Latest: Q3 2026 Earnings Reported 10/28/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Total RevenueReported240.00 Mil240.00 Mil -9.4% LoweredGuidance: 265.00 Mil for 2026


Prior: Q2 2026 Earnings Reported 8/5/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Total revenuesReported240.00 Mil265.00 Mil290.00 Mil0 AffirmedGuidance: 265.00 Mil for 2026
2026 Fanapt and BYSANTI net product salesReported150.00 Mil160.00 Mil170.00 Mil0 AffirmedGuidance: 160.00 Mil for 2026
2026 NEREUS net product salesReported10.00 Mil20.00 Mil30.00 Mil0 AffirmedGuidance: 20.00 Mil for 2026
2026 Other net product salesReported80.00 Mil85.00 Mil90.00 Mil0 AffirmedGuidance: 85.00 Mil for 2026

Q1 2026 Earnings Reported 5/6/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Total revenuesReported240.00 Mil265.00 Mil290.00 Mil8.2% RaisedGuidance: 245.00 Mil for 2026
2026 Fanapt net product salesReported150.00 Mil160.00 Mil170.00 Mil0 AffirmedGuidance: 160.00 Mil for 2026
2026 NEREUS net product salesReported10.00 Mil20.00 Mil30.00 Mil   
2026 Other net product salesReported80.00 Mil85.00 Mil90.00 Mil0 AffirmedGuidance: 85.00 Mil for 2026

Q4 2025 Earnings Reported 2/11/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Total revenuesReported230.00 Mil245.00 Mil260.00 Mil11.4% Higher NewGuidance: 220.00 Mil for 2025
2026 Fanapt net product salesReported150.00 Mil160.00 Mil170.00 Mil   
2026 Other net product salesReported80.00 Mil85.00 Mil90.00 Mil   

Insider Activity

Updated 11/5/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Duncan, Charles Cliff DirectBuy110520263.805,80322,076413,520Form
2Duncan, Charles Cliff DirectBuy110520263.823,44713,171393,173Form
3Duncan, Charles Cliff DirectBuy110520263.807502,847377,506Form
4Moran, Kevin PatrickSVP, CFO & TreasurerDirectSell30420268.2742,442350,8213,400,426Form
5Wijkstrom, JoakimSVP, Chief Marketing OfficerDirectSell30420268.2730,800254,5902,756,421Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Duncan, Charles Cliff DirectBuy110520263.805,80322,076413,520Form
2Duncan, Charles Cliff DirectBuy110520263.823,44713,171393,173Form
3Duncan, Charles Cliff DirectBuy110520263.807502,847377,506Form
4Moran, Kevin PatrickSVP, CFO & TreasurerDirectSell30420268.2742,442350,8213,400,426Form
5Wijkstrom, JoakimSVP, Chief Marketing OfficerDirectSell30420268.2730,800254,5902,756,421Form
6Williams, TimothySVP & General CounselDirectSell30420268.2742,434350,7553,119,964Form
7Polymeropoulos, Mihael HristosPresident and CEODirectSell30420268.17156,2351,276,97122,104,928Form
8Birznieks, GuntherSVP, Business DevelopmentDirectSell30420268.2742,431350,7304,084,983Form
9Honore, Tage DirectSell22420268.0330,000240,900750,556Form
Core Cache Last Updated: 11/7/2026