Tearsheet

Vanda Pharmaceuticals (VNDA)


Market Price (3/3/2026): $8.19 | Market Cap: $484.0 Mil
Sector: Health Care | Industry: Biotechnology

Vanda Pharmaceuticals (VNDA)


Market Price (3/3/2026): $8.19
Market Cap: $484.0 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -52%
Weak multi-year price returns
3Y Excs Rtn is -49%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -151 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -70%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.
  Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -4.1%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -51%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -51%
3   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 61%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -50%
5   Key risks
VNDA key risks include [1] significant financial distress, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -52%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
3Y Excs Rtn is -49%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -151 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -70%
4 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -4.1%
5 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -51%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -51%
6 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 61%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -50%
8 Key risks
VNDA key risks include [1] significant financial distress, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) stock has gained about 50% since 11/30/2025 because of the following key factors:

1. Positive Phase 2 Clinical Trial Results for Tradipitant in GLP-1 Induced Nausea and Vomiting.

Vanda Pharmaceuticals announced positive topline results on November 17, 2025, from its Phase 2 study evaluating tradipitant for the prevention of nausea and vomiting induced by GLP-1 receptor agonist Wegovy. The study met its primary endpoint, demonstrating a 50% relative reduction in vomiting among tradipitant-treated participants compared to placebo. This significant development positions tradipitant as a potential adjunct therapy in the rapidly expanding GLP-1 agonist market and led to an initial 17% rise in Vanda's shares.

2. FDA Approval of NEREUS (Tradipitant) for Motion-Induced Vomiting and Lifting of Clinical Hold.

On December 4, 2025, the FDA lifted a partial clinical hold on Vanda's tradipitant protocol for motion sickness treatment, agreeing that motion sickness is an acute, self-limiting response, which removed the requirement for an additional six-month dog toxicity study. This regulatory development, which allowed for extended clinical studies, was followed by the FDA's approval of NEREUS (tradipitant) for the prevention of vomiting induced by motion by December 30, 2025. This marked the first new oral therapy for motion-induced vomiting prevention in over 40 years and contributed to an 11% rise in VNDA's stock in after-hours trading.

Show more

Stock Movement Drivers

Fundamental Drivers

The 52.4% change in VNDA stock from 11/30/2025 to 3/2/2026 was primarily driven by a 49.6% change in the company's P/S Multiple.
(LTM values as of)113020253022026Change
Stock Price ($)5.368.1752.4%
Change Contribution By: 
Total Revenues ($ Mil)2122161.9%
P/S Multiple1.52.249.6%
Shares Outstanding (Mil)59590.0%
Cumulative Contribution52.4%

LTM = Last Twelve Months as of date shown

Market Drivers

11/30/2025 to 3/2/2026
ReturnCorrelation
VNDA52.4% 
Market (SPY)0.4%-8.8%
Sector (XLV)0.6%22.2%

Fundamental Drivers

The 72.7% change in VNDA stock from 8/31/2025 to 3/2/2026 was primarily driven by a 62.9% change in the company's P/S Multiple.
(LTM values as of)83120253022026Change
Stock Price ($)4.738.1772.7%
Change Contribution By: 
Total Revenues ($ Mil)2032166.2%
P/S Multiple1.42.262.9%
Shares Outstanding (Mil)5959-0.2%
Cumulative Contribution72.7%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 3/2/2026
ReturnCorrelation
VNDA72.7% 
Market (SPY)6.7%3.3%
Sector (XLV)15.9%21.1%

Fundamental Drivers

The 71.6% change in VNDA stock from 2/28/2025 to 3/2/2026 was primarily driven by a 60.0% change in the company's P/S Multiple.
(LTM values as of)22820253022026Change
Stock Price ($)4.768.1771.6%
Change Contribution By: 
Total Revenues ($ Mil)1992168.7%
P/S Multiple1.42.260.0%
Shares Outstanding (Mil)5859-1.3%
Cumulative Contribution71.6%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2025 to 3/2/2026
ReturnCorrelation
VNDA71.6% 
Market (SPY)16.5%11.8%
Sector (XLV)7.9%26.6%

Fundamental Drivers

The 26.9% change in VNDA stock from 2/28/2023 to 3/2/2026 was primarily driven by a 55.8% change in the company's P/S Multiple.
(LTM values as of)22820233022026Change
Stock Price ($)6.448.1726.9%
Change Contribution By: 
Total Revenues ($ Mil)254216-15.0%
P/S Multiple1.42.255.8%
Shares Outstanding (Mil)5759-4.1%
Cumulative Contribution26.9%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2023 to 3/2/2026
ReturnCorrelation
VNDA26.9% 
Market (SPY)79.7%12.7%
Sector (XLV)30.5%25.9%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
VNDA Return19%-53%-43%14%84%1%-32%
Peers Return-17%33%10%-0%42%-8%58%
S&P 500 Return27%-19%24%23%16%0%83%

Monthly Win Rates [3]
VNDA Win Rate58%25%42%50%50%33% 
Peers Win Rate50%58%53%50%62%13% 
S&P 500 Win Rate75%42%67%75%67%33% 

Max Drawdowns [4]
VNDA Max Drawdown0%-56%-54%-18%-18%-35% 
Peers Max Drawdown-40%-27%-30%-22%-21%-15% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-1% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: NBIX, ACAD, SUPN, AXSM, HRMY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 3/2/2026 (YTD)

How Low Can It Go

Unique KeyEventVNDAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-84.3%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven536.4%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-55.3%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven123.9%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven330 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-61.0%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven156.5%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-98.4%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven6234.0%131.3%
2008 Global Financial CrisisTime to BreakevenTime to BreakevenNot Fully Recovered days1,480 days

Compare to NBIX, ACAD, SUPN, AXSM, HRMY

In The Past

Vanda Pharmaceuticals's stock fell -84.3% during the 2022 Inflation Shock from a high on 6/30/2021. A -84.3% loss requires a 536.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Vanda Pharmaceuticals (VNDA)

Vanda Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of therapies to address high unmet medical needs. The company's marketed products include HETLIOZ for the treatment of non-24-hour sleep-wake disorders; and Fanapt oral tablets for the treatment of schizophrenia. Its products under development include HETLIOZ (tasimelteon) for the treatment of jet lag disorder, smith-magenis syndrome, pediatric Non-24, autism spectrum, and delayed sleep phase disorder; Fanapt (iloperidone) for the treatment of bipolar disorder and a long acting injectable formulation program for the treatment of schizophrenia; and Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist, for the treatment of atopic dermatitis, gastroparesis, and motion sickness. The company's products under development also comprise VTR-297, a small molecule histone deacetylase inhibitor for the treatment of hematologic malignancies and with potential use as a treatment for various oncology indications; VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist for the treatment of psychiatric disorders; a portfolio of cystic fibrosis transmembrane conductance regulator activators and inhibitors for the treatment of dry eye and ocular inflammation, as well as BPO-27 for the treatment of secretory diarrhea disorders, including cholera; and VHX-896, the active metabolite of iloperidone. It markets its products in the United States, Europe, and Israel. Vanda Pharmaceuticals Inc. was incorporated in 2002 and is headquartered in Washington, the District of Columbia.

AI Analysis | Feedback

Here are 1-2 brief analogies for Vanda Pharmaceuticals:

  1. Vanda Pharmaceuticals is like a specialized Biogen, focusing on niche neurological and rare sleep disorders.

  2. Vanda Pharmaceuticals is like a smaller Jazz Pharmaceuticals, specializing in rare sleep and psychiatric disorders.

AI Analysis | Feedback

  • Hetlioz (tasimelteon): A medication used to treat Non-24-hour sleep-wake disorder and nighttime sleep disturbances in Smith-Magenis Syndrome.
  • Fanapt (iloperidone): An atypical antipsychotic medication prescribed for the treatment of schizophrenia.

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) sells primarily to other companies. Its major customers are pharmaceutical wholesale distributors responsible for distributing its products to pharmacies, hospitals, clinics, and other healthcare providers.

  • McKesson Corporation (NYSE: MCK)
  • Cencora, Inc. (formerly AmerisourceBergen Corporation) (NYSE: COR)
  • Cardinal Health, Inc. (NYSE: CAH)

AI Analysis | Feedback

null

AI Analysis | Feedback

Mihael H. Polymeropoulos, MD President, Chief Executive Officer and Chairman of the Board

Dr. Polymeropoulos co-founded Vanda Pharmaceuticals in 2003 in partnership with Care Capital LLC, a biopharmaceuticals-focused investment firm, and Bio*One Capital, an investment arm of the Singapore government. He has served as President, Chief Executive Officer, and Chairman of the Board since 2021, and as President, Chief Executive Officer and Director from 2003 to 2021. Prior to Vanda, he was Vice President and Head of the Pharmacogenetics Department at Novartis AG from 1998 to 2003. He also served as Chief of the Gene Mapping Section at the National Human Genome Research Institute from 1992 to 1998, and co-founded the Integrated Molecular Analysis of Genome Expression (I.M.A.G.E.) Consortium.

Kevin Moran Senior Vice President, Chief Financial Officer and Treasurer

Mr. Moran has served as Senior Vice President, Chief Financial Officer, and Treasurer of Vanda Pharmaceuticals since July 2020. He joined Vanda in September 2010 and held various finance roles, including Vice President, Acting Chief Financial Officer and Treasurer (March 2020 to July 2020) and Vice President and Controller (March 2018 to March 2020). Before joining Vanda, Mr. Moran was a Senior Associate at PricewaterhouseCoopers.

Tim Williams Senior Vice President, General Counsel and Secretary

Mr. Williams has served as Senior Vice President, General Counsel, and Secretary since August 2018. Prior to Vanda, he was Executive Vice President, General Counsel, Chief Compliance Officer, and Corporate Secretary at AgNovos Healthcare, a medical device company, from September 2013 to July 2018. From 2009 to 2013, he was Senior Legal Counsel and Assistant Secretary at Stryker Corporation, where he was involved in global M&A, corporate governance, and securities.

Gunther Birznieks Senior Vice President, Business Development

Mr. Birznieks holds the position of Senior Vice President, Business Development at Vanda Pharmaceuticals. A detailed background including founding/managing other companies, selling companies, or patterns of managing private equity-backed companies was not readily available in the search results.

Joakim Wijkstrom Senior Vice President, Chief Marketing Officer

Mr. Wijkstrom has served as Senior Vice President, Chief Marketing Officer since 2019. His prior experience includes serving as Senior Vice President and Chief Marketing Officer at Perry Ellis International, and various leadership roles in advertising agencies.

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) faces several key business risks, primarily centered on its financial performance, regulatory challenges, and product-specific competition. First, **profitability and overall financial health** represent a significant risk. The company has demonstrated negative net margins, experienced a 3-year revenue growth decline, and is grappling with ongoing cash burn and quarterly losses. Its Altman Z-Score, which assesses the probability of bankruptcy, has been in the distress zone, indicating potential financial instability within the next two years. Second, **regulatory uncertainty and a history of disputes with the U.S. Food and Drug Administration (FDA)** pose a considerable risk. Vanda has had repeated disagreements with the FDA, which some sources suggest may hinder a constructive working relationship with the agency. While there have been recent positive developments, such as the FDA lifting a partial clinical hold on tradipitant and agreeing to expedited re-reviews for other applications, the outcomes of these regulatory processes for pipeline candidates remain uncertain and critical for future growth. Third, **impending generic competition for key products** threatens Vanda's revenue streams. HETLIOZ, one of Vanda's marketed products, is expected to face generic competition beyond 2026. The loss of exclusivity for this product could lead to a substantial decrease in revenue and a rapid erosion of market share and pricing power, requiring the company to successfully commercialize newer products to offset these losses.

AI Analysis | Feedback

The primary clear emerging threat for Vanda Pharmaceuticals is the impending loss of market exclusivity for its flagship product, Hetlioz (tasimelteon). Vanda has settled patent litigation with several generic manufacturers, allowing for the entry of generic tasimelteon products starting in December 2026. As Hetlioz represents the substantial majority of Vanda's current revenue, the introduction of generic competition is expected to significantly erode its market share and revenue. This known and scheduled event constitutes a fundamental threat to the company's financial future as the date of generic entry approaches.

AI Analysis | Feedback

```html

Addressable Markets for Vanda Pharmaceuticals' Main Products

  • Hetlioz (tasimelteon)
    • Non-24-Hour Sleep-Wake Disorder (Non-24): Approximately 70% of totally blind individuals with sleep complaints are not entrained to the 24-hour clock (U.S.).
    • Smith-Magenis Syndrome (SMS): No specific market size in patient numbers or dollar value was identified, but it is considered a rare circadian rhythm disorder (U.S.).
  • Fanapt (iloperidone)
    • Schizophrenia: The schizophrenia treatment market is described as a lucrative niche (U.S.).
    • Bipolar I Disorder: Affects approximately 2.8% of adults in the United States, with total cases of bipolar I disorder depression in the U.S. observed as approximately 935,000 in 2021.
    • Vanda projects its psychiatry portfolio, which includes Fanapt, to generate over $750 million annually by 2030.
  • Ponvory (ponesimod)
    • Relapsing forms of Multiple Sclerosis (RMS): No specific market size in patient numbers or dollar value was identified (U.S. and Canada).
    • Psoriasis (in Phase III development): Over 8 million people are diagnosed with psoriasis (U.S.).
    • Ulcerative Colitis (in Phase III development): Estimated prevalence in the U.S. is approximately 2 million individuals.
  • Tradipitant (pipeline product)
    • Gastroparesis: An analyst eyed potential peak sales of nearly $900 million if the drug receives FDA approval for this indication.
  • VGT-1849A (pipeline product for polycythemia vera)
    • Polycythemia Vera: The market size is expected to reach $2.03 billion by 2032 (global).
```

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) is anticipated to drive future revenue growth over the next two to three years through several key initiatives:

  1. Expansion of Fanapt® (iloperidone) Commercialization: The commercial launch of Fanapt® for the acute treatment of bipolar I disorder is a significant driver, with new patient starts showing substantial increases. Vanda is investing in expanding its sales force and marketing efforts for this indication. Additionally, the development of a long-acting injectable (LAI) formulation of Fanapt® is expected to further contribute to the psychiatry portfolio's growth.

  2. Launch of Bysanti™ (milsaperidone): Bysanti™, the active metabolite of Fanapt®, is expected to be a major contributor to Vanda's psychiatry franchise. The New Drug Application (NDA) for bipolar I disorder and schizophrenia has been accepted for filing, with a PDUFA target action date of February 21, 2026. This product is seen as having the potential to drive significant future growth.

  3. Introduction of Tradipitant for Motion Sickness: Vanda submitted an NDA for tradipitant for motion sickness, which has been accepted for filing with a PDUFA target action date of December 30, 2025. This represents a new product launch that can diversify revenue streams.

  4. Commercialization of Imsidolimab for Generalized Pustular Psoriasis: The Biologics License Application (BLA) for imsidolimab in generalized pustular psoriasis is expected to be submitted in 2025, with potential market entry in the coming years. This will strengthen Vanda's anti-inflammatory portfolio.

  5. Indication Expansion for PONVORY®: Vanda is exploring additional indications for its multiple sclerosis drug, PONVORY®. Investigational New Drug (IND) applications for PONVORY® in the treatment of psoriasis and ulcerative colitis were accepted in the fourth quarter of 2024, indicating potential for revenue growth through market expansion for an existing product.

AI Analysis | Feedback

Outbound Investments

  • Vanda Pharmaceuticals completed the acquisition of the U.S. and Canadian rights to PONVORY from Actelion Pharmaceuticals Ltd. (Janssen) for $100.0 million in December 2023.

Capital Expenditures

  • Vanda Pharmaceuticals reported capital expenditures of $2 million in 2020, $1 million in 2021, $1 million in 2022, $0 million in 2023, and $0 million in 2024.
  • Projected capital expenditures are $1 million for 2025, $1 million for 2026, and $1 million for 2027.

Better Bets vs. Vanda Pharmaceuticals (VNDA)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select ideas related to VNDA.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
QDEL_2282026_Insider_Buying_45D_2Buy_200K02282026QDELQuidelOrthoInsiderInsider Buys 45DStrong Insider Buying
Companies with multiple insider buys in the last 45 days
0.0%0.0%0.0%
CHE_2272026_Dip_Buyer_FCFYield02272026CHEChemedDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
0.0%0.0%0.0%
LLY_2272026_Monopoly_xInd_xCD_Getting_Cheaper02272026LLYEli LillyMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.0%0.0%0.0%
HAE_2202026_Dip_Buyer_FCFYield02202026HAEHaemoneticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
3.5%3.5%0.0%
IQV_2132026_Dip_Buyer_ValueBuy02132026IQVIQVIADip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
7.1%7.1%-3.0%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Mkt Price8.17132.3822.8155.09166.3828.9042.00
Mkt Cap0.513.33.93.18.41.73.5
Rev LTM2162,8601,047682638826754
Op Inc LTM-15163694-29-16922633
FCF LTM-1107469971-9429785
FCF 3Y Avg-3855570112-12322991
CFO LTM-10978319972-93298135
CFO 3Y Avg-37589103113-122229108

Growth & Margins

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Rev Chg LTM8.7%21.4%12.7%4.5%65.5%21.1%16.9%
Rev Chg 3Y Avg-4.1%24.3%27.8%1.3%183.0%27.4%25.9%
Rev Chg Q7.6%28.3%11.3%9.3%65.0%28.7%19.8%
QoQ Delta Rev Chg LTM1.9%6.6%2.8%2.5%13.8%6.9%4.7%
Op Mgn LTM-70.0%22.3%9.0%-4.2%-26.5%27.3%2.4%
Op Mgn 3Y Avg-32.5%22.6%-1.1%3.7%-53.2%29.9%1.3%
QoQ Delta Op Mgn LTM-12.9%1.6%0.2%-14.9%8.2%-1.4%-0.6%
CFO/Rev LTM-50.6%27.4%19.0%10.5%-14.6%36.0%14.8%
CFO/Rev 3Y Avg-17.3%24.4%8.7%17.5%-33.8%33.2%13.1%
FCF/Rev LTM-51.1%26.1%9.5%10.4%-14.7%35.9%9.9%
FCF/Rev 3Y Avg-17.6%23.0%5.5%17.3%-34.0%33.2%11.4%

Valuation

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Mkt Cap0.513.33.93.18.41.73.5
P/S2.24.63.74.613.22.04.1
P/EBIT-3.220.840.8-471.3-47.66.81.8
P/E-2.227.714.7-163.0-46.09.03.4
P/CFO-4.416.919.443.3-90.25.611.3
Total Yield-45.7%3.6%6.8%-0.6%-2.2%11.2%1.5%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-7.3%4.0%2.4%5.7%-2.7%11.3%3.2%
D/E0.00.00.00.00.00.10.0
Net D/E-0.5-0.1-0.2-0.1-0.0-0.3-0.1

Returns

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
1M Rtn8.4%-2.7%-9.2%14.4%-9.7%-20.9%-6.0%
3M Rtn62.7%-12.3%-8.2%23.2%11.6%-18.6%1.7%
6M Rtn72.7%-5.2%-12.2%22.1%37.2%-21.7%8.5%
12M Rtn71.6%11.5%16.4%71.8%30.5%-14.6%23.4%
3Y Rtn28.3%30.8%12.1%38.4%154.9%-33.2%29.5%
1M Excs Rtn6.3%-2.8%-10.0%13.5%-8.9%-20.3%-5.9%
3M Excs Rtn53.1%-13.7%-9.1%18.1%9.2%-19.7%0.1%
6M Excs Rtn68.0%-10.6%-18.9%15.6%30.8%-29.7%2.5%
12M Excs Rtn56.4%-4.7%0.5%56.1%14.2%-29.2%7.4%
3Y Excs Rtn-49.2%-41.5%-52.1%-28.8%97.1%-108.8%-45.4%

Comparison Analyses

null

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA220358  BYSANTImilsaperidonetablet220202641.8%41.8%41.8%41.8%41.8%
NDA220152  NEREUStradipitantcapsule1230202516.2%16.2%16.2%16.2%16.2%
NDA213498  PONVORYponesimodtablet318202114.7%-4.6%-29.4%-61.7%-52.1%
NDA214517  HETLIOZ LQtasimelteonsuspension1201202045.5%44.3%29.3%-11.2%-33.8%
NDA205677  HETLIOZtasimelteoncapsule13120149.7%6.3%-15.9%-35.5%-38.2%
NDA022192  FANAPTiloperidonetablet50620091,386.1%814.8%650.9%616.7%656.5%

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
HETLIOZ ® net product sales100160174161143
Fanapt ® net product sales9195958784
PONVORY ® net product sales20   
Total193254269248227


Price Behavior

Price Behavior
Market Price$8.17 
Market Cap ($ Bil)0.5 
First Trading Date04/12/2006 
Distance from 52W High-8.3% 
   50 Days200 Days
DMA Price$7.47$5.46
DMA Trendupup
Distance from DMA9.3%49.6%
 3M1YR
Volatility125.8%77.3%
Downside Capture-318.1543.08
Upside Capture16.1391.56
Correlation (SPY)-7.5%12.0%
VNDA Betas & Captures as of 2/28/2026

 1M2M3M6M1Y3Y
Beta-0.41-1.58-0.900.310.470.55
Up Beta2.322.842.661.600.210.30
Down Beta0.41-3.37-1.920.650.670.70
Up Capture13%-48%71%104%99%37%
Bmk +ve Days9203170142431
Stock +ve Days12233566121343
Down Capture-214%-291%-346%-106%53%89%
Bmk -ve Days12213054109320
Stock -ve Days9182656123380

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA74.2%77.1%1.03-
Sector ETF (XLV)9.1%17.4%0.3526.6%
Equity (SPY)18.4%19.3%0.7511.8%
Gold (GLD)86.5%25.7%2.417.8%
Commodities (DBC)16.5%17.1%0.734.2%
Real Estate (VNQ)7.1%16.6%0.2411.5%
Bitcoin (BTCUSD)-22.3%45.0%-0.436.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA-15.3%59.1%-0.05-
Sector ETF (XLV)8.5%14.5%0.4026.5%
Equity (SPY)13.6%17.0%0.6319.8%
Gold (GLD)23.9%17.2%1.145.9%
Commodities (DBC)11.1%19.0%0.472.0%
Real Estate (VNQ)5.1%18.8%0.1721.2%
Bitcoin (BTCUSD)6.2%56.8%0.339.0%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with VNDA
VNDA0.2%55.2%0.22-
Sector ETF (XLV)10.8%16.5%0.5431.6%
Equity (SPY)15.3%17.9%0.7327.1%
Gold (GLD)15.6%15.6%0.843.5%
Commodities (DBC)8.9%17.6%0.428.4%
Real Estate (VNQ)6.5%20.7%0.2823.3%
Bitcoin (BTCUSD)65.1%66.8%1.057.2%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date2132026
Short Interest: Shares Quantity3.5 Mil
Short Interest: % Change Since 13120267.6%
Average Daily Volume1.3 Mil
Days-to-Cover Short Interest2.7 days
Basic Shares Quantity59.1 Mil
Short % of Basic Shares5.9%

Earnings Returns History

Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
2/11/2026-17.6%-17.9% 
10/29/2025-20.1%-17.9%-7.2%
7/31/2025-8.8%-9.6%0.6%
5/7/2025-3.7%-10.5%5.3%
2/13/2025-6.0%-5.7%8.1%
11/6/20242.7%11.7%-1.0%
7/31/2024-3.4%-11.0%-10.6%
5/8/2024-6.5%0.0%14.2%
...
SUMMARY STATS   
# Positive8911
# Negative171613
Median Positive6.6%7.9%6.3%
Median Negative-6.0%-10.7%-11.0%
Max Positive21.2%20.0%23.1%
Max Negative-21.9%-18.4%-23.3%

SEC Filings

Expand for More
Report DateFiling DateFiling
12/31/202502/12/202610-K
09/30/202510/30/202510-Q
06/30/202507/31/202510-Q
03/31/202505/08/202510-Q
12/31/202402/14/202510-K
09/30/202411/07/202410-Q
06/30/202408/01/202410-Q
03/31/202405/09/202410-Q
12/31/202302/08/202410-K
09/30/202311/09/202310-Q
06/30/202307/28/202310-Q
03/31/202305/03/202310-Q
12/31/202202/09/202310-K
09/30/202211/03/202210-Q
06/30/202208/04/202210-Q
03/31/202205/06/202210-Q

Insider Activity

Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Polymeropoulos, Mihael HristosPresident and CEODirectBuy80820254.1510,00041,5009,693,284Form
2Mitchell, Stephen Ray DirectSell61620254.597,00032,130445,606Form
3Polymeropoulos, Mihael HristosPresident and CEODirectBuy52120254.4010,00043,99510,232,098Form
4Polymeropoulos, Mihael HristosPresident and CEODirectBuy51920254.2220,00084,4729,780,721Form
5Polymeropoulos, Mihael HristosPresident and CEODirectBuy30620255.0110,00050,15011,513,091Form