Tearsheet

Vanda Pharmaceuticals (VNDA)


Market Price (1/21/2026): $7.64 | Market Cap: $451.5 Mil
Sector: Health Care | Industry: Biotechnology

Vanda Pharmaceuticals (VNDA)


Market Price (1/21/2026): $7.64
Market Cap: $451.5 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -62%
Weak multi-year price returns
3Y Excs Rtn is -74%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -121 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -57%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.
  Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -5.6%
2   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -39%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -39%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -23%
4   Key risks
VNDA key risks include [1] significant financial distress, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -62%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, Biotechnology & Genomics, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
3Y Excs Rtn is -74%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -121 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -57%
4 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -5.6%
5 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -39%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -39%
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -23%
7 Key risks
VNDA key risks include [1] significant financial distress, Show more.

Valuation, Metrics & Events

VNDA Stock


Why The Stock Moved


Qualitative Assessment

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) stock has gained about 55% since 9/30/2025 because of the following key factors:

1. FDA Approval of NEREUSâ„¢ (tradipitant) for Motion Sickness.Vanda Pharmaceuticals received FDA approval for NEREUSâ„¢ (tradipitant) for the prevention of vomiting induced by motion on December 30, 2025, a significant milestone as it marks the first new pharmacologic treatment for motion sickness in over 40 years. This approval, which had a PDUFA target action date of December 30, 2025, was a major catalyst, causing the stock to jump approximately 21% upon the announcement. The commercial launch of NEREUSâ„¢ is expected in early 2026.

2. Lifting of FDA Partial Clinical Hold on Tradipitant.Prior to the approval, the FDA lifted a partial clinical hold on long-term studies of tradipitant for motion sickness around December 5, 2025. This action removed a previous 90-dose limit, enabling extended studies and indicating the FDA's confidence in the drug's safety and efficacy. This decision streamlined the clinical pathway and expanded Vanda's ability to conduct broader testing of tradipitant.

Show more

Stock Movement Drivers

Fundamental Drivers

The 77.2% change in VNDA stock from 10/31/2025 to 1/20/2026 was primarily driven by a 77.2% change in the company's P/S Multiple.
103120251202026Change
Stock Price ($)4.357.7177.24%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)212.07212.070.00%
P/S Multiple1.212.1577.24%
Shares Outstanding (Mil)59.0959.090.00%
Cumulative Contribution77.24%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 1/20/2026
ReturnCorrelation
VNDA77.2% 
Market (SPY)-0.7%-6.2%
Sector (XLV)7.7%14.7%

Fundamental Drivers

The 81.0% change in VNDA stock from 7/31/2025 to 1/20/2026 was primarily driven by a 73.9% change in the company's P/S Multiple.
73120251202026Change
Stock Price ($)4.267.7180.99%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)203.47212.074.23%
P/S Multiple1.242.1573.93%
Shares Outstanding (Mil)58.9959.09-0.17%
Cumulative Contribution80.99%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2025 to 1/20/2026
ReturnCorrelation
VNDA81.0% 
Market (SPY)7.5%10.4%
Sector (XLV)19.7%18.2%

Fundamental Drivers

The 74.8% change in VNDA stock from 1/31/2025 to 1/20/2026 was primarily driven by a 59.6% change in the company's P/S Multiple.
13120251202026Change
Stock Price ($)4.417.7174.83%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)190.86212.0711.12%
P/S Multiple1.352.1559.58%
Shares Outstanding (Mil)58.2659.09-1.42%
Cumulative Contribution74.79%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2025 to 1/20/2026
ReturnCorrelation
VNDA74.8% 
Market (SPY)13.6%15.7%
Sector (XLV)7.2%28.0%

Fundamental Drivers

The 0.4% change in VNDA stock from 1/31/2023 to 1/20/2026 was primarily driven by a 27.5% change in the company's P/S Multiple.
13120231202026Change
Stock Price ($)7.687.710.39%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)257.92212.07-17.77%
P/S Multiple1.682.1527.52%
Shares Outstanding (Mil)56.5759.09-4.45%
Cumulative Contribution0.19%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2023 to 1/20/2026
ReturnCorrelation
VNDA0.4% 
Market (SPY)72.9%15.1%
Sector (XLV)22.0%26.7%

Return vs. Risk


Price Returns Compared

 202120222023202420252026Total [1]
Returns
VNDA Return19%-53%-43%14%84%-15%-43%
Peers Return-17%33%10%-0%42%-3%66%
S&P 500 Return27%-19%24%23%16%1%85%

Monthly Win Rates [3]
VNDA Win Rate58%25%42%50%50%0% 
Peers Win Rate50%58%53%50%62%20% 
S&P 500 Win Rate75%42%67%75%67%100% 

Max Drawdowns [4]
VNDA Max Drawdown0%-56%-54%-18%-18%-17% 
Peers Max Drawdown-40%-27%-30%-22%-21%-5% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%0% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: NBIX, ACAD, SUPN, AXSM, HRMY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 1/20/2026 (YTD)

How Low Can It Go

Unique KeyEventVNDAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-84.3%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven536.4%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-55.3%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven123.9%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven330 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-61.0%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven156.5%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-98.4%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven6234.0%131.3%
2008 Global Financial CrisisTime to BreakevenTime to BreakevenNot Fully Recovered days1,480 days

Compare to NBIX, ACAD, SUPN, AXSM, HRMY

In The Past

Vanda Pharmaceuticals's stock fell -84.3% during the 2022 Inflation Shock from a high on 6/30/2021. A -84.3% loss requires a 536.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Vanda Pharmaceuticals (VNDA)

Vanda Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of therapies to address high unmet medical needs. The company's marketed products include HETLIOZ for the treatment of non-24-hour sleep-wake disorders; and Fanapt oral tablets for the treatment of schizophrenia. Its products under development include HETLIOZ (tasimelteon) for the treatment of jet lag disorder, smith-magenis syndrome, pediatric Non-24, autism spectrum, and delayed sleep phase disorder; Fanapt (iloperidone) for the treatment of bipolar disorder and a long acting injectable formulation program for the treatment of schizophrenia; and Tradipitant (VLY-686), a small molecule neurokinin-1 receptor (NK-1R) antagonist, for the treatment of atopic dermatitis, gastroparesis, and motion sickness. The company's products under development also comprise VTR-297, a small molecule histone deacetylase inhibitor for the treatment of hematologic malignancies and with potential use as a treatment for various oncology indications; VQW-765, a small molecule nicotinic acetylcholine receptor partial agonist for the treatment of psychiatric disorders; a portfolio of cystic fibrosis transmembrane conductance regulator activators and inhibitors for the treatment of dry eye and ocular inflammation, as well as BPO-27 for the treatment of secretory diarrhea disorders, including cholera; and VHX-896, the active metabolite of iloperidone. It markets its products in the United States, Europe, and Israel. Vanda Pharmaceuticals Inc. was incorporated in 2002 and is headquartered in Washington, the District of Columbia.

AI Analysis | Feedback

Here are 1-2 brief analogies for Vanda Pharmaceuticals:

  1. Vanda Pharmaceuticals is like a specialized Biogen, focusing on niche neurological and rare sleep disorders.

  2. Vanda Pharmaceuticals is like a smaller Jazz Pharmaceuticals, specializing in rare sleep and psychiatric disorders.

AI Analysis | Feedback

  • Hetlioz (tasimelteon): A medication used to treat Non-24-hour sleep-wake disorder and nighttime sleep disturbances in Smith-Magenis Syndrome.
  • Fanapt (iloperidone): An atypical antipsychotic medication prescribed for the treatment of schizophrenia.

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) sells primarily to other companies. Its major customers are pharmaceutical wholesale distributors responsible for distributing its products to pharmacies, hospitals, clinics, and other healthcare providers.

  • McKesson Corporation (NYSE: MCK)
  • Cencora, Inc. (formerly AmerisourceBergen Corporation) (NYSE: COR)
  • Cardinal Health, Inc. (NYSE: CAH)

AI Analysis | Feedback

null

AI Analysis | Feedback

Mihael H. Polymeropoulos, MD President, Chief Executive Officer and Chairman of the Board

Dr. Polymeropoulos co-founded Vanda Pharmaceuticals in 2003 in partnership with Care Capital LLC, a biopharmaceuticals-focused investment firm, and Bio*One Capital, an investment arm of the Singapore government. He has served as President, Chief Executive Officer, and Chairman of the Board since 2021, and as President, Chief Executive Officer and Director from 2003 to 2021. Prior to Vanda, he was Vice President and Head of the Pharmacogenetics Department at Novartis AG from 1998 to 2003. He also served as Chief of the Gene Mapping Section at the National Human Genome Research Institute from 1992 to 1998, and co-founded the Integrated Molecular Analysis of Genome Expression (I.M.A.G.E.) Consortium.

Kevin Moran Senior Vice President, Chief Financial Officer and Treasurer

Mr. Moran has served as Senior Vice President, Chief Financial Officer, and Treasurer of Vanda Pharmaceuticals since July 2020. He joined Vanda in September 2010 and held various finance roles, including Vice President, Acting Chief Financial Officer and Treasurer (March 2020 to July 2020) and Vice President and Controller (March 2018 to March 2020). Before joining Vanda, Mr. Moran was a Senior Associate at PricewaterhouseCoopers.

Tim Williams Senior Vice President, General Counsel and Secretary

Mr. Williams has served as Senior Vice President, General Counsel, and Secretary since August 2018. Prior to Vanda, he was Executive Vice President, General Counsel, Chief Compliance Officer, and Corporate Secretary at AgNovos Healthcare, a medical device company, from September 2013 to July 2018. From 2009 to 2013, he was Senior Legal Counsel and Assistant Secretary at Stryker Corporation, where he was involved in global M&A, corporate governance, and securities.

Gunther Birznieks Senior Vice President, Business Development

Mr. Birznieks holds the position of Senior Vice President, Business Development at Vanda Pharmaceuticals. A detailed background including founding/managing other companies, selling companies, or patterns of managing private equity-backed companies was not readily available in the search results.

Joakim Wijkstrom Senior Vice President, Chief Marketing Officer

Mr. Wijkstrom has served as Senior Vice President, Chief Marketing Officer since 2019. His prior experience includes serving as Senior Vice President and Chief Marketing Officer at Perry Ellis International, and various leadership roles in advertising agencies.

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) faces several key business risks, primarily centered on its financial performance, regulatory challenges, and product-specific competition. First, **profitability and overall financial health** represent a significant risk. The company has demonstrated negative net margins, experienced a 3-year revenue growth decline, and is grappling with ongoing cash burn and quarterly losses. Its Altman Z-Score, which assesses the probability of bankruptcy, has been in the distress zone, indicating potential financial instability within the next two years. Second, **regulatory uncertainty and a history of disputes with the U.S. Food and Drug Administration (FDA)** pose a considerable risk. Vanda has had repeated disagreements with the FDA, which some sources suggest may hinder a constructive working relationship with the agency. While there have been recent positive developments, such as the FDA lifting a partial clinical hold on tradipitant and agreeing to expedited re-reviews for other applications, the outcomes of these regulatory processes for pipeline candidates remain uncertain and critical for future growth. Third, **impending generic competition for key products** threatens Vanda's revenue streams. HETLIOZ, one of Vanda's marketed products, is expected to face generic competition beyond 2026. The loss of exclusivity for this product could lead to a substantial decrease in revenue and a rapid erosion of market share and pricing power, requiring the company to successfully commercialize newer products to offset these losses.

AI Analysis | Feedback

The primary clear emerging threat for Vanda Pharmaceuticals is the impending loss of market exclusivity for its flagship product, Hetlioz (tasimelteon). Vanda has settled patent litigation with several generic manufacturers, allowing for the entry of generic tasimelteon products starting in December 2026. As Hetlioz represents the substantial majority of Vanda's current revenue, the introduction of generic competition is expected to significantly erode its market share and revenue. This known and scheduled event constitutes a fundamental threat to the company's financial future as the date of generic entry approaches.

AI Analysis | Feedback

```html

Addressable Markets for Vanda Pharmaceuticals' Main Products

  • Hetlioz (tasimelteon)
    • Non-24-Hour Sleep-Wake Disorder (Non-24): Approximately 70% of totally blind individuals with sleep complaints are not entrained to the 24-hour clock (U.S.).
    • Smith-Magenis Syndrome (SMS): No specific market size in patient numbers or dollar value was identified, but it is considered a rare circadian rhythm disorder (U.S.).
  • Fanapt (iloperidone)
    • Schizophrenia: The schizophrenia treatment market is described as a lucrative niche (U.S.).
    • Bipolar I Disorder: Affects approximately 2.8% of adults in the United States, with total cases of bipolar I disorder depression in the U.S. observed as approximately 935,000 in 2021.
    • Vanda projects its psychiatry portfolio, which includes Fanapt, to generate over $750 million annually by 2030.
  • Ponvory (ponesimod)
    • Relapsing forms of Multiple Sclerosis (RMS): No specific market size in patient numbers or dollar value was identified (U.S. and Canada).
    • Psoriasis (in Phase III development): Over 8 million people are diagnosed with psoriasis (U.S.).
    • Ulcerative Colitis (in Phase III development): Estimated prevalence in the U.S. is approximately 2 million individuals.
  • Tradipitant (pipeline product)
    • Gastroparesis: An analyst eyed potential peak sales of nearly $900 million if the drug receives FDA approval for this indication.
  • VGT-1849A (pipeline product for polycythemia vera)
    • Polycythemia Vera: The market size is expected to reach $2.03 billion by 2032 (global).
```

AI Analysis | Feedback

Vanda Pharmaceuticals (VNDA) is anticipated to drive future revenue growth over the next two to three years through several key initiatives:

  1. Expansion of Fanapt® (iloperidone) Commercialization: The commercial launch of Fanapt® for the acute treatment of bipolar I disorder is a significant driver, with new patient starts showing substantial increases. Vanda is investing in expanding its sales force and marketing efforts for this indication. Additionally, the development of a long-acting injectable (LAI) formulation of Fanapt® is expected to further contribute to the psychiatry portfolio's growth.

  2. Launch of Bysanti™ (milsaperidone): Bysanti™, the active metabolite of Fanapt®, is expected to be a major contributor to Vanda's psychiatry franchise. The New Drug Application (NDA) for bipolar I disorder and schizophrenia has been accepted for filing, with a PDUFA target action date of February 21, 2026. This product is seen as having the potential to drive significant future growth.

  3. Introduction of Tradipitant for Motion Sickness: Vanda submitted an NDA for tradipitant for motion sickness, which has been accepted for filing with a PDUFA target action date of December 30, 2025. This represents a new product launch that can diversify revenue streams.

  4. Commercialization of Imsidolimab for Generalized Pustular Psoriasis: The Biologics License Application (BLA) for imsidolimab in generalized pustular psoriasis is expected to be submitted in 2025, with potential market entry in the coming years. This will strengthen Vanda's anti-inflammatory portfolio.

  5. Indication Expansion for PONVORY®: Vanda is exploring additional indications for its multiple sclerosis drug, PONVORY®. Investigational New Drug (IND) applications for PONVORY® in the treatment of psoriasis and ulcerative colitis were accepted in the fourth quarter of 2024, indicating potential for revenue growth through market expansion for an existing product.

AI Analysis | Feedback

Outbound Investments

  • Vanda Pharmaceuticals completed the acquisition of the U.S. and Canadian rights to PONVORY from Actelion Pharmaceuticals Ltd. (Janssen) for $100.0 million in December 2023.

Capital Expenditures

  • Vanda Pharmaceuticals reported capital expenditures of $2 million in 2020, $1 million in 2021, $1 million in 2022, $0 million in 2023, and $0 million in 2024.
  • Projected capital expenditures are $1 million for 2025, $1 million for 2026, and $1 million for 2027.

Better Bets than Vanda Pharmaceuticals (VNDA)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select ideas related to VNDA. For more, see Trefis Trade Ideas.

Unique Key

Recent Active Movers

More From Trefis

Peer Comparisons for Vanda Pharmaceuticals

Peers to compare with:

Financials

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Mkt Price7.71134.5426.2949.82184.5035.9142.86
Mkt Cap0.513.44.42.89.22.13.6
Rev LTM2122,6831,047682561826754
Op Inc LTM-12155494-29-19522633
FCF LTM-835939971-10129785
FCF 3Y Avg-2547370112-12622991
CFO LTM-8263719972-101298135
CFO 3Y Avg-25508103113-125229108

Growth & Margins

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Rev Chg LTM11.1%19.6%12.7%4.5%65.8%21.1%16.1%
Rev Chg 3Y Avg-5.6%24.6%27.8%1.3%296.0%27.4%26.0%
Rev Chg Q18.1%27.8%11.3%9.3%63.2%28.7%22.9%
QoQ Delta Rev Chg LTM4.2%6.9%2.8%2.5%13.4%6.9%5.6%
Op Mgn LTM-57.1%20.6%9.0%-4.2%-34.7%27.3%2.4%
Op Mgn 3Y Avg-25.6%22.1%-1.1%3.7%-63.2%29.9%1.3%
QoQ Delta Op Mgn LTM-7.6%0.8%0.2%-14.9%7.3%-1.4%-0.6%
CFO/Rev LTM-38.6%23.7%19.0%10.5%-18.0%36.0%14.8%
CFO/Rev 3Y Avg-11.9%22.6%8.7%17.5%-40.3%33.2%13.1%
FCF/Rev LTM-39.1%22.1%9.5%10.4%-18.1%35.9%9.9%
FCF/Rev 3Y Avg-12.2%21.1%5.5%17.3%-40.4%33.2%11.4%

Valuation

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
Mkt Cap0.513.44.42.89.22.13.6
P/S2.15.04.24.116.42.54.2
P/EBIT-3.822.947.0-426.2-41.48.42.3
P/E-5.431.217.0-147.4-40.211.12.9
P/CFO-5.621.022.339.2-91.46.914.0
Total Yield-18.5%3.2%5.9%-0.7%-2.5%9.0%1.3%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-4.0%3.5%2.4%5.7%-2.7%11.3%2.9%
D/E0.00.00.00.00.00.10.0
Net D/E-0.6-0.1-0.2-0.1-0.0-0.2-0.1

Returns

VNDANBIXACADSUPNAXSMHRMYMedian
NameVanda Ph.Neurocri.ACADIA P.Supernus.Axsome T.Harmony . 
1M Rtn14.2%-7.2%-3.2%-3.2%20.9%-5.0%-3.2%
3M Rtn45.7%-5.7%23.6%-1.7%40.4%37.3%30.4%
6M Rtn63.7%1.3%16.5%52.5%79.9%-2.1%34.5%
12M Rtn76.8%-6.1%49.6%32.0%100.7%-8.0%40.8%
3Y Rtn2.3%20.8%35.9%23.6%160.5%-27.5%22.2%
1M Excs Rtn11.9%-6.2%-3.5%1.1%23.5%-8.5%-1.2%
3M Excs Rtn44.3%-6.0%23.9%-2.7%42.2%36.7%30.3%
6M Excs Rtn57.7%-5.7%10.2%42.1%60.4%-5.9%26.2%
12M Excs Rtn59.2%-19.7%35.6%17.1%82.4%-21.3%26.3%
3Y Excs Rtn-74.1%-47.8%-27.3%-42.0%113.6%-95.4%-44.9%

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA220152  NEREUStradipitantcapsule123020259.7%9.7%9.7%9.7%9.7%
NDA213498  PONVORYponesimodtablet318202114.7%-4.6%-29.4%-61.7%-54.8%
NDA214517  HETLIOZ LQtasimelteonsuspension1201202045.5%44.3%29.3%-11.2%-37.5%
NDA205677  HETLIOZtasimelteoncapsule13120149.7%6.3%-15.9%-35.5%-41.7%
NDA022192  FANAPTiloperidonetablet50620091,386.1%814.8%650.9%616.7%613.9%

Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
HETLIOZ ® net product sales100160174161143
Fanapt ® net product sales9195958784
PONVORY ® net product sales20   
Total193254269248227


Price Behavior

Price Behavior
Market Price$7.71 
Market Cap ($ Bil)0.5 
First Trading Date04/12/2006 
Distance from 52W High-12.6% 
   50 Days200 Days
DMA Price$6.21$5.01
DMA Trendupup
Distance from DMA24.2%53.8%
 3M1YR
Volatility102.9%61.6%
Downside Capture-109.6063.99
Upside Capture109.82113.45
Correlation (SPY)5.7%16.2%
VNDA Betas & Captures as of 12/31/2025

 1M2M3M6M1Y3Y
Beta-1.28-0.120.811.170.520.62
Up Beta6.001.130.741.350.130.27
Down Beta-1.772.182.561.490.720.83
Up Capture404%254%206%228%117%42%
Bmk +ve Days11233772143431
Stock +ve Days13243562119342
Down Capture-849%-473%-129%34%69%95%
Bmk -ve Days11182755108320
Stock -ve Days9172760125380

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 VNDA vs. Other Asset Classes (Last 1Y)
 VNDASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return73.3%12.0%15.3%75.7%3.6%7.5%-7.9%
Annualized Volatility61.3%17.3%19.3%20.3%15.3%16.8%34.3%
Sharpe Ratio1.130.500.612.670.030.26-0.08
Correlation With Other Assets 28.4%15.5%-4.3%-1.2%16.1%12.0%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
 VNDA vs. Other Asset Classes (Last 5Y)
 VNDASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-11.2%7.3%13.8%20.4%11.5%6.0%21.1%
Annualized Volatility56.0%14.5%17.1%15.7%18.7%18.8%48.0%
Sharpe Ratio0.010.330.651.050.500.220.47
Correlation With Other Assets 26.6%21.3%1.9%1.4%22.6%11.4%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 VNDA vs. Other Asset Classes (Last 10Y)
 VNDASector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-1.1%10.6%15.3%15.4%8.0%5.7%70.5%
Annualized Volatility53.3%16.6%18.0%14.9%17.6%20.8%55.7%
Sharpe Ratio0.190.530.730.860.370.240.91
Correlation With Other Assets 32.7%28.6%0.5%8.2%24.4%8.1%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date12312025
Short Interest: Shares Quantity2,335,804
Short Interest: % Change Since 12152025-52.3%
Average Daily Volume3,604,016
Days-to-Cover Short Interest1
Basic Shares Quantity59,091,478
Short % of Basic Shares4.0%

Earnings Returns History

Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/29/2025-20.1%-17.9%-7.2%
7/31/2025-8.8%-9.6%0.6%
5/7/2025-3.7%-10.5%5.3%
2/13/2025-6.0%-5.7%8.1%
11/6/20242.7%11.7%-1.0%
7/31/2024-3.4%-11.0%-10.6%
5/8/2024-6.5%0.0%14.2%
2/7/202411.8%16.8%6.3%
...
SUMMARY STATS   
# Positive8911
# Negative161513
Median Positive6.6%7.9%6.3%
Median Negative-5.3%-10.5%-11.0%
Max Positive21.2%20.0%23.1%
Max Negative-21.9%-18.4%-23.3%

SEC Filings

Expand for More
Report DateFiling DateFiling
09/30/202510/30/202510-Q (09/30/2025)
06/30/202507/31/202510-Q (06/30/2025)
03/31/202505/08/202510-Q (03/31/2025)
12/31/202402/14/202510-K (12/31/2024)
09/30/202411/07/202410-Q (09/30/2024)
06/30/202408/01/202410-Q (06/30/2024)
03/31/202405/09/202410-Q (03/31/2024)
12/31/202302/08/202410-K (12/31/2023)
09/30/202311/09/202310-Q (09/30/2023)
06/30/202307/28/202310-Q (06/30/2023)
03/31/202305/03/202310-Q (03/31/2023)
12/31/202202/09/202310-K (12/31/2022)
09/30/202211/03/202210-Q (09/30/2022)
06/30/202208/04/202210-Q (06/30/2022)
03/31/202205/06/202210-Q (03/31/2022)
12/31/202102/24/202210-K (12/31/2021)

Insider Activity

Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Polymeropoulos, Mihael HristosPresident and CEODirectBuy80820254.1510,00041,5009,693,284Form
2Mitchell, Stephen Ray DirectSell61620254.597,00032,130445,606Form
3Polymeropoulos, Mihael HristosPresident and CEODirectBuy52120254.4010,00043,99510,232,098Form
4Polymeropoulos, Mihael HristosPresident and CEODirectBuy51920254.2220,00084,4729,780,721Form
5Polymeropoulos, Mihael HristosPresident and CEODirectBuy30620255.0110,00050,15011,513,091Form