Supernus Pharmaceuticals (SUPN)


Market Price (9/5/2026): $43.53 | Market Cap: $2.5 BilSector: Health Care | Industry: Pharmaceuticals

Supernus Pharmaceuticals (SUPN)


Market Price (9/5/2026): $43.53
Market Cap: $2.5 Bil
Sector: Health Care
Industry: Pharmaceuticals

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -13%

Low stock price volatility
Vol 12M is 36%

Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Targeted Therapies, and Biopharmaceutical R&D.

Weak multi-year price returns
2Y Excs Rtn is -13%, 3Y Excs Rtn is -35%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -55 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -6.7%

Expensive valuation multiples
P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 127x

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -8.8%

Key risks
SUPN key risks include [1] patent disputes and regulatory scrutiny from bodies like the FTC over its core CNS drugs, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -13%
1 Low stock price volatility
Vol 12M is 36%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine. Themes include Targeted Therapies, and Biopharmaceutical R&D.
3 Weak multi-year price returns
2Y Excs Rtn is -13%, 3Y Excs Rtn is -35%
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -55 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -6.7%
5 Expensive valuation multiples
P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 127x
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -8.8%
7 Key risks
SUPN key risks include [1] patent disputes and regulatory scrutiny from bodies like the FTC over its core CNS drugs, Show more.

SUPN in ETFs

Weight = SUPN's share of each fund

VTI0.00%
ITOT0.00%
IWM0.08%
IJR0.15%
VB0.03%
IJT0.21%
SLYG0.20%
IWN0.14%
+14 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

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Updated on 9/1/2026

Supernus Pharmaceuticals (SUPN) stock has lost about 5% since 5/31/2026 because of the following key factors:

1. Significant GAAP Net Loss in Fiscal Q2 2026. Supernus Pharmaceuticals reported a GAAP net loss of $58.4 million, or $1.01 per share, for fiscal Q2 2026 (ended June 2026). This loss was primarily due to a substantial non-cash impairment charge of $54.9 million related to APOKYN, leading to a significant miss against the analyst consensus estimate of a $0.51 profit per share. This directly impacted the company's short-term profitability.

2. Investor Uncertainty Post-Indivior Merger Announcement. The announcement on August 3, 2026, of an all-stock merger of equals with Indivior Pharmaceuticals, while strategically aimed at creating a diversified CNS biopharmaceutical leader with approximately $125 million in annual cost synergies, introduced short-term investor apprehension. Concerns regarding integration complexities, potential shareholder dilution from the all-stock nature of the deal, and the timeline for realizing projected benefits likely contributed to a cautious market response, tempering the stock's initial positive reaction.

Show more
Updated on 9/1/2026

Supernus Pharmaceuticals (SUPN) stock has lost about 5% since 5/31/2026 because of the following key factors:

1. Significant GAAP Net Loss in Fiscal Q2 2026. Supernus Pharmaceuticals reported a GAAP net loss of $58.4 million, or $1.01 per share, for fiscal Q2 2026 (ended June 2026). This loss was primarily due to a substantial non-cash impairment charge of $54.9 million related to APOKYN, leading to a significant miss against the analyst consensus estimate of a $0.51 profit per share. This directly impacted the company's short-term profitability.

2. Investor Uncertainty Post-Indivior Merger Announcement. The announcement on August 3, 2026, of an all-stock merger of equals with Indivior Pharmaceuticals, while strategically aimed at creating a diversified CNS biopharmaceutical leader with approximately $125 million in annual cost synergies, introduced short-term investor apprehension. Concerns regarding integration complexities, potential shareholder dilution from the all-stock nature of the deal, and the timeline for realizing projected benefits likely contributed to a cautious market response, tempering the stock's initial positive reaction.

3. Persistent Concerns over Per-Share Profitability Trend. Underlying investor sentiment may have been influenced by a longer-term trend of declining per-share profitability. Over the five years prior to August 2026, Supernus's Earnings Per Share (EPS) declined by 24.9% annually, even as revenue grew by 6.7%. This indicates the company has become less profitable on a per-share basis as it expanded, potentially contributing to a lower valuation or making the stock more susceptible to declines on negative news.

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Stock Movement Drivers

Fundamental Drivers

The -5.7% change in SUPN stock from 5/31/2026 to 9/4/2026 was primarily driven by a -11.2% change in the company's P/S Multiple.
(LTM values as of)53120269042026Change
Stock Price ($)46.1843.53-5.7%
Change Contribution By: 
Total Revenues ($ Mil)7778306.9%
P/S Multiple3.43.0-11.2%
Shares Outstanding (Mil)5858-0.7%
Cumulative Contribution-5.7%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2026 to 9/4/2026
ReturnCorrelation
SUPN-5.7% 
Market (SPY)1.8%-13.6%
Sector (XLV)14.7%33.8%

Fundamental Drivers

The -20.5% change in SUPN stock from 2/28/2026 to 9/4/2026 was primarily driven by a -33.0% change in the company's P/S Multiple.
(LTM values as of)22820269042026Change
Stock Price ($)54.7343.53-20.5%
Change Contribution By: 
Total Revenues ($ Mil)68283021.8%
P/S Multiple4.53.0-33.0%
Shares Outstanding (Mil)5758-2.6%
Cumulative Contribution-20.5%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2026 to 9/4/2026
ReturnCorrelation
SUPN-20.5% 
Market (SPY)12.6%19.7%
Sector (XLV)7.5%42.5%

Fundamental Drivers

The -3.5% change in SUPN stock from 8/31/2025 to 9/4/2026 was primarily driven by a -19.9% change in the company's P/S Multiple.
(LTM values as of)83120259042026Change
Stock Price ($)45.1243.53-3.5%
Change Contribution By: 
Total Revenues ($ Mil)66583024.9%
P/S Multiple3.83.0-19.9%
Shares Outstanding (Mil)5658-3.5%
Cumulative Contribution-3.5%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 9/4/2026
ReturnCorrelation
SUPN-3.5% 
Market (SPY)20.4%15.5%
Sector (XLV)26.4%27.7%

Fundamental Drivers

The 36.7% change in SUPN stock from 8/31/2023 to 9/4/2026 was primarily driven by a 31.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)83120239042026Change
Stock Price ($)31.8443.5336.7%
Change Contribution By: 
Total Revenues ($ Mil)63483031.0%
P/S Multiple2.73.011.2%
Shares Outstanding (Mil)5558-6.1%
Cumulative Contribution36.7%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2023 to 9/4/2026
ReturnCorrelation
SUPN36.7% 
Market (SPY)77.1%21.4%
Sector (XLV)34.7%20.1%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
SUPN Return16%22%-19%25%37%-12%75%
Peers Return-28%16%58%-0%52%23%149%
S&P 500 Return27%-19%24%23%16%13%106%

Monthly Win Rates [3]
SUPN Win Rate50%67%50%50%58%22% 
Peers Win Rate52%53%55%48%63%56% 
S&P 500 Win Rate75%42%67%75%67%56% 

Max Drawdowns [4]
SUPN Max Drawdown-29%-26%-46%-27%-24%-23% 
Peers Max Drawdown-52%-43%-37%-31%-32%-20% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: JAZZ, NBIX, ACAD, AXSM, AMRX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 9/4/2026 (YTD)

How Low Can It Go

EventSUPNS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-25.0%-9.5%
  % Gain to Breakeven33.3%10.5%
  Time to Breakeven124 days24 days
2023 SVB Regional Banking Crisis
  % Loss-25.1%-6.7%
  % Gain to Breakeven33.6%7.1%
  Time to Breakeven580 days31 days
2022 Inflation Shock & Fed Tightening
  % Loss-15.8%-24.5%
  % Gain to Breakeven18.8%32.4%
  Time to Breakeven56 days427 days
2020 COVID-19 Crash
  % Loss-40.7%-33.7%
  % Gain to Breakeven68.6%50.9%
  Time to Breakeven62 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-37.7%-19.2%
  % Gain to Breakeven60.5%23.8%
  Time to Breakeven2481 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-33.1%-3.7%
  % Gain to Breakeven49.5%3.9%
  Time to Breakeven61 days6 days

Compare to JAZZ, NBIX, ACAD, AXSM, AMRX

In The Past

Supernus Pharmaceuticals's stock fell -9.6% during the 2025 US Tariff Shock. Such a loss loss requires a 10.7% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventSUPNS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-25.0%-9.5%
  % Gain to Breakeven33.3%10.5%
  Time to Breakeven124 days24 days
2023 SVB Regional Banking Crisis
  % Loss-25.1%-6.7%
  % Gain to Breakeven33.6%7.1%
  Time to Breakeven580 days31 days
2020 COVID-19 Crash
  % Loss-40.7%-33.7%
  % Gain to Breakeven68.6%50.9%
  Time to Breakeven62 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-37.7%-19.2%
  % Gain to Breakeven60.5%23.8%
  Time to Breakeven2481 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-33.1%-3.7%
  % Gain to Breakeven49.5%3.9%
  Time to Breakeven61 days6 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-44.9%-12.2%
  % Gain to Breakeven81.3%13.9%
  Time to Breakeven109 days62 days

Compare to JAZZ, NBIX, ACAD, AXSM, AMRX

In The Past

Supernus Pharmaceuticals's stock fell -9.6% during the 2025 US Tariff Shock. Such a loss loss requires a 10.7% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Supernus Pharmaceuticals (SUPN)

Supernus Pharmaceuticals, Inc. (SUPN) is a biopharmaceutical company dedicated to the development and commercialization of innovative treatments for central nervous system (CNS) diseases. The company primarily operates within the United States, focusing on addressing significant medical needs in neurological and psychiatric disorders.

The company's commercial product portfolio is extensive, targeting a range of CNS conditions. Key offerings include Trokendi XR and Oxtellar XR for epilepsy and migraine prevention, and Qelbree for attention-deficit hyperactivity disorder (ADHD) in pediatric patients. Supernus also provides multiple treatments for Parkinson's Disease, such as APOKYN, XADAGO, GOCOVRI, and Osmolex ER, along with MYOBLOC for cervical dystonia and sialorrhea.

Beyond its marketed products, Supernus maintains an active pipeline with drug candidates in various stages of clinical development for conditions like ADHD, Parkinson's disease, severe epilepsy, and resistant depression, signaling future growth potential. The company distributes its products to patients across the United States through a network of pharmaceutical wholesalers, specialty pharmacies, and distributors.

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A Biogen that focuses on a wider array of Central Nervous System (CNS) diseases like epilepsy, ADHD, and Parkinson's.

Like Eli Lilly, but exclusively dedicated to brain and nerve disorders.

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  • Trokendi XR: An extended-release topiramate product indicated for the treatment of epilepsy and for the prophylaxis of migraine headache.
  • Oxtellar XR: An extended-release oxcarbazepine for the monotherapy treatment of partial onset epilepsy seizures.
  • Qelbree: A selective norepinephrine reuptake inhibitor indicated for the treatment of attention-deficit hyperactivity disorder (ADHD) in pediatric patients.
  • APOKYN: Used for the acute intermittent treatment of hypomobility or off episodes in patients with advanced Parkinson's Disease (PD).
  • XADAGO: Treats levodopa/carbidopa in patients with Parkinson's Disease experiencing off episodes.
  • MYOBLOC: A Type B toxin product indicated for the treatment of cervical dystonia and sialorrhea in adults.
  • GOCOVRI: Treats dyskinesia in patients with Parkinson's Disease.
  • Osmolex ER: Used for the treatment of Parkinson's disease and drug-induced extrapyramidal reaction in adult patients.

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The major customers of Supernus Pharmaceuticals (SUPN) are:
  • Pharmaceutical wholesalers
  • Specialty pharmacies
  • Distributors

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Jack A. Khattar, President, Chief Executive Officer, and Director

Mr. Khattar is the founder of Supernus Pharmaceuticals, Inc., serving as President, CEO, and Director since 2005. From 1999 to 2005, he held various positions including board member, President, and CEO of Shire Laboratories Inc., the drug delivery subsidiary of Shire plc, and was a member of Shire plc's Executive Committee from 1999 to 2004. Before that, he was an Executive Officer and Chairman of the Management Committee at CIMA Labs Inc., a drug delivery company, where his responsibilities included business development, corporate alliances, and strategic planning. Prior to joining CIMA in 1995, he held several marketing and business development positions at Merck & Co., Novartis, Playtex, and Kodak across the United States, Europe, and the Middle East. He currently serves on the Board of Directors of Prevacus, Inc., a privately-held biotechnology company, and is Chairman of the Board of scPharmaceuticals and Cognition Therapeutics Inc., both publicly traded pharmaceutical companies. He also serves on the advisory board of New Rhein Healthcare, a private equity firm. He earned his BBA in Marketing from the American University of Beirut and an MBA from the Wharton School of the University of Pennsylvania.

Timothy C. Dec, Senior Vice President, Chief Financial Officer

Mr. Dec joined Supernus as Senior Vice-President of Finance in August 2021. He brings over 35 years of experience in accounting and finance, including chief financial officer or other senior financial executive roles at three publicly traded companies listed on Nasdaq, and with private equity-backed companies. Most recently, from April 2015 to July 2021, he served as Chief Financial Officer of OpGen, Inc., a Nasdaq-listed company. Prior to that, he was Senior Vice President and Chief Financial Officer for Clubwidesports, LLC, a start-up sports management software company, from January 2014 to April 2015. From August 2007 to December 2012, he was Senior Vice President and Chief Financial Officer of Fortress International Group, Inc., a publicly traded company. He also served as Senior Vice President, Chief Financial Officer of Presidio Networked Solutions, a private company, from June 2006 to August 2007, and as Senior Vice President, Chief Accounting Officer and Treasurer of Broadwing Corporation (formerly Corvis Corporation), a publicly traded company, from June 1999 to June 2006. He holds a B.S. in accounting from Mount St. Mary's University and an M.B.A. in finance from American University.

Padmanabh P. Bhatt, Ph.D., Senior Vice President, Chief Scientific Officer, Intellectual Property

Dr. Bhatt has served as Senior Vice President of Intellectual Property and Chief Scientific Officer since March 2012, having joined Supernus in 2005 as Vice President of Pharmaceutical Sciences. His prior experience includes serving as Vice President of Advanced Drug Delivery at Shire Laboratories, Inc. (2003-2005), Vice President of Research and Development and Chief Technology Officer at Point Biomedical Corporation (2001-2003), and various roles at ALZA (now a Johnson & Johnson company) from Product Development Manager to Director of Technical Development (1996-2001).

Todd Horich, Ph.D., MBA, Senior Vice President of Marketing and Market Access, and Commercial Operations

Dr. Horich joined Supernus in 2010 as the first commercial employee and has been instrumental in building the commercial organization, integrating corporate acquisitions, and successfully launching key products like Trokendi XR®, Oxtellar XR®, and Qelbree®. He has served as Senior Vice President of Marketing and Market Access since May 2021, and Commercial Operations since December 2023. Prior to Supernus, he held increasing responsibilities at Novartis Pharmaceuticals Inc., and Director-level positions with Vanda Pharmaceuticals and Medimmune, Inc.

Bryan A. Roecklein, Ph.D., Vice President of Corporate Development

Dr. Roecklein joined Supernus in July 2015 as Vice President of Corporate Development. Before Supernus, he was a member of the U.S. Executive Team at Meda Pharmaceuticals, where he led the Corporate Development function. From 2001 to 2011, at MedPointe, then Meda Pharmaceuticals, Dr. Roecklein held various positions in Portfolio Management, New Product Planning, Marketing, Medical Education, and Commercial Development.

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Key Business Risks for Supernus Pharmaceuticals (SUPN)

  1. Loss of Market Exclusivity/Patent Expiry: Supernus Pharmaceuticals relies on its proprietary commercial products, such as Trokendi XR, Oxtellar XR, Qelbree, and others, for its revenue. The eventual expiration of patents or other forms of market exclusivity for these key products would allow generic competitors to enter the market, leading to a significant decline in sales and profitability for Supernus's established portfolio. This "patent cliff" risk is inherent to the pharmaceutical industry and can substantially impact a company's financial performance once exclusivity is lost.
  2. Clinical Trial Failures and Regulatory Approval Risk: Supernus has a pipeline of product candidates in various stages of development, including SPN-830 (late-stage for PD), SPN-817 (Phase I for epilepsy), and SPN-820 (Phase II for resistant depression). The success of these candidates is crucial for the company's long-term growth and future revenue streams. There is a high risk that these product candidates may fail to demonstrate efficacy or safety in clinical trials, experience delays, or fail to receive regulatory approval from agencies like the FDA. Such failures would result in substantial financial losses from research and development investments and hinder the introduction of new products to the market.
  3. Intense Competition: Supernus operates in the central nervous system (CNS) disease market, which is characterized by intense competition. Its commercial products for conditions like epilepsy, migraine, ADHD, and Parkinson's Disease face competition from existing branded and generic therapies, as well as new treatments developed by other pharmaceutical companies. This competition can lead to pricing pressures, reduced market share, and increased marketing expenses, impacting the profitability of Supernus's current products and the potential market penetration of its pipeline candidates.

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Here are the addressable market sizes for Supernus Pharmaceuticals' main products:

  • Trokendi XR (epilepsy): The U.S. epilepsy drug market size is accounted for USD 4.02 billion in 2025 and is projected to be worth around USD 6.38 billion by 2034. In 2024, the U.S. epilepsy treatment drugs market was valued at USD 3.1 billion and is projected to grow to USD 4.7 billion by 2034. The global epileptic seizures treatment market size is estimated at USD 12.56 billion in 2025, with the United States holding a significant share of USD 3.67 billion in 2025.
  • Trokendi XR (migraine headache prophylaxis): The U.S. migraine treatment market was valued at USD 4.85 billion in 2024 and is projected to reach USD 12.08 billion by 2032. The global extended migraine prophylactics market size is estimated at USD 4.06 billion in 2025 and is predicted to increase to approximately USD 11.66 billion by 2034. North America dominated the extended migraine prophylactics market, holding 40% of the market share in 2024.
  • Oxtellar XR (partial onset epilepsy seizures): This product addresses a segment of the broader epilepsy market. The focal seizures segment, which includes partial onset seizures, held the largest market share of 51% in 2024 within the U.S. epilepsy drug market. The overall U.S. epilepsy drug market information from Trokendi XR is also relevant here.
  • Qelbree (ADHD): The U.S. attention deficit hyperactivity disorder (ADHD) market size was estimated at USD 10.31 billion in 2024 and is projected to reach USD 13.88 billion by 2033. Another estimate places the U.S. ADHD Therapeutics Market size at USD 5.47 billion in 2025, expected to reach USD 6.68 billion by 2035. The global ADHD therapeutics market size was valued at USD 15.8 billion in 2023 and is estimated to grow to USD 24.6 billion by 2032.
  • APOKYN, XADAGO, GOCOVRI, and Osmolex ER (Parkinson's Disease related indications): The Parkinson's Disease treatment market in the U.S. was approximately USD 1.88 billion in 2023 and generated USD 1.94 billion in 2024, expected to reach USD 2.60 billion by 2030. The global Parkinson's disease diagnosis and treatment market is expected to increase from USD 7.49 billion in 2025 to USD 17.57 billion by 2035, with North America holding a major revenue share in 2025. Specifically for "off episodes" in Parkinson's disease, XADAGO is indicated for an estimated 1 million patients in the U.S. affected by Parkinson's disease. For levodopa-induced dyskinesia in Parkinson's disease (relevant for GOCOVRI), the U.S. market size was approximately USD 900 million in 2023, while the global market was around USD 1.5 billion in 2023.
  • MYOBLOC (cervical dystonia): The Cervical Dystonia market size in the U.S. was approximately USD 222.2 million in 2022. Across the seven major markets (7MM: US, EU4, UK, and Japan), the market reached USD 156.5 million in 2024 and is expected to reach USD 288.3 million by 2035. The global cervical dystonia market is estimated to be valued at USD 281.5 million in 2025 and is expected to reach USD 428.9 million by 2032. North America is estimated to capture over 50.3% of the revenue share by 2035.
  • MYOBLOC (sialorrhea): The global chronic sialorrhea treatment market size was valued at USD 0.735 billion in 2023 and is expected to grow to nearly USD 1.06 billion by 2030. The sialorrhea treatment market was valued at US$ 695.06 million in 2022 and is expected to reach US$ 1,042.37 million by 2030. The United States accounts for the highest market share of Sialorrhea among the 7MM. North America holds approximately 60% of the global market share.

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Supernus Pharmaceuticals (SUPN) anticipates several key drivers for its future revenue growth over the next two to three years, primarily stemming from the continued expansion of its core therapeutic portfolio, successful integration of recent acquisitions, and advancement of its pipeline.

Here are 4 expected drivers of future revenue growth:

  1. Continued Strong Sales Growth of Key Commercial Products: Supernus expects significant revenue growth from its "four growth products": Qelbree, GOCOVRI, ZURZUVAE, and ONAPGO. These products collectively drove over 20% growth in Q4 2025 and accounted for approximately 76% of total revenues in that quarter. Qelbree (for ADHD) continues to demonstrate strong prescription growth, with a 29.6% increase in Q4 2025 and an expanding base of prescribers. GOCOVRI (for Parkinson's dyskinesia) is also a significant contributor to sales growth. Supernus has provided full-year 2026 revenue guidance ranging from $840 million to $870 million, indicating a projected growth of 32% to 37%.
  2. Expansion and Increased Market Penetration for ZURZUVAE: Acquired through the Sage Therapeutics acquisition in 2025, ZURZUVAE (for postpartum depression) is a crucial growth driver with expectations for significant growth in a large, untapped market. The company reported $32.8 million in collaboration revenues from ZURZUVAE in Q4 2025 alone, and is planning a new direct-to-consumer campaign to raise awareness.
  3. Increased Uptake and Resolved Supply for ONAPGO: ONAPGO (for Parkinson's off episodes), launched in April 2025, has experienced "incredible performance" and strong demand, despite initial supply constraints. Supernus has made progress in securing additional supply, with new patient initiation resuming in Q1 2026, and is working towards a second supplier by 2027 to meet demand. ONAPGO sales are projected to range from $45 million to $70 million in 2026.
  4. Advancement and Potential Commercialization of Late-Stage Pipeline Assets: The company's pipeline offers future growth potential. Data readouts are anticipated in 2027 for SPN-817, a novel candidate in Phase 2b trials for treatment-resistant focal seizures, and SPN-820, a Phase 2b product candidate for major depressive disorder that is poised for significant impact. Additionally, Phase 1 trials for SPN-443, an ADHD stimulant, are scheduled for 2026.

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Capital Allocation Decisions for Supernus Pharmaceuticals (SUPN) (2021-2025)

Share Repurchases

  • Supernus Pharmaceuticals engaged in share repurchase programs across 2024 and the first half of 2025, with repurchases exceeding $150 million.
  • These share repurchase programs contributed to a reduction in the company's public float and a concentration of institutional ownership.
  • An aggressive capital-return program, including share repurchases, led to a shift towards greater institutional concentration in Supernus's ownership from 2022 through mid-2025.

Share Issuance

  • The company's shares outstanding have shown some fluctuations over the last few years, with reported figures ranging from approximately 0.054 billion at the end of 2021 to 0.057 billion by September 2025.
  • Share issuances are related to share-based compensation expenses for employee stock purchase plans and various share-based awards.
  • Insider activity indicates the acquisition of common stock through the settlement of performance share units and the exercise of stock options.

Outbound Investments

  • In 2021, Supernus Pharmaceuticals completed the acquisition of Adamas Pharmaceuticals for $450 million.

Capital Expenditures

  • Capital expenditures in the most recent reported quarter totaled approximately $0.13 million.
  • While specific annual capital expenditure figures were not directly provided, they are a component in the calculation of Supernus Pharmaceuticals's free cash flow, which was $0.125 billion in 2021, $0.116 billion in 2022, $0.111 billion in 2023, and $0.171 billion in 2024.

Better Bets vs. Supernus Pharmaceuticals (SUPN)

Peer Outperformance in Pharmaceuticals

SUPN has outperformed 73% of its 62 Pharmaceuticals peers over 5Y. Among the peers that beat it are INDV, AMRX and JNJ. Pharmaceuticals ranks 7th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Pharmaceuticals constituents that SUPN has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
46%
of 74 industry peers · -4.2% return
3Y
61%
of 69 industry peers · 37.1% return
5Y
73%
of 62 industry peers · 58.5% return
Pharmaceuticals peers with revenue growth within 4pp of SUPN's that beat it on at least 2 of 3 windows, and by at least 20pp over 5Y. Growth is matched by construction, so the gap is largely a re-rating gap. The multiple column is the context for it.
Ticker Name Rev Growth 3Y Avg P/E 1Y3Y5Y 5Y Gap
SUPN Supernus Pharmaceuticals 9.9% -23.0x -4.2%37.1%58.5%
INDV Indivior Pharmaceuticals 10.1% 11.7x 41.3%54.4%1147.9% +1,089pp
AMRX Amneal Pharmaceuticals 10.5% 35.4x 82.6%356.5%221.8% +163pp
JNJ Johnson & Johnson 6.0% 31.5x 57.4%86.5%80.8% +22pp
JAZZ Jazz Pharmaceuticals 7.0% 16.6x 92.8%77.6%80.2% +22pp
Price returns, excluding dividends. P/E shown for context only and not used for matching.
Median price return by industry across the Health Care sector, ranked by 5Y. Pharmaceuticals is SUPN's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 7 13.9%96.3%127.8% CAH 414% · MCK 351% · COR 179%
Managed Health Care 8 33.2%1.7%3.3% OSCR 77% · HQY 48% · ELV 16%
Health Care Services 20 21.0%52.1%-1.5% HIMS 238% · RDNT 134% · DGX 68%
Health Care Facilities 24 1.8%4.9%-19.0% THC 249% · NHC 244% · ENSG 108%
Health Care Equipment 50 -5.3%-4.8%-24.0% POCI 10775% · UFPT 318% · GKOS 200%
Health Care Supplies 12 32.3%-14.4%-35.5% LNTH 272% · HAE 59% · MMSI 23%
Pharmaceuticals ← 63 -0.9%0.6%-36.4% LQDA 2406% · INDV 1148% · ETON 1022%
Life Sciences Tools & Services 109 2.4%-28.7%-73.9% SNWV 1688% · MEDP 203% · AXGN 178%
Biotechnology 363 8.8%-25.7%-76.8% BRTX 73900% · DNTH 1558% · CELZ 1486%
Health Care Technology 20 -25.0%-56.7%-78.6% SPOK 68% · HSTM -2% · VEEV -13%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Latest Trefis Analyses

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

SUPNJAZZNBIXACADAXSMAMRXMedian
NameSupernus.Jazz Pha.Neurocri.ACADIA P.Axsome T.Amneal P. 
Mkt Price43.53246.81155.6428.02206.6817.4499.58
Mkt Cap2.515.615.74.810.75.68.1
Rev LTM8304,6013,3741,1397773,1182,128
Op Inc LTM-551,01680686-183479283
FCF LTM191,31186851-72-1235
FCF 3Y Avg1201,18963073-120142131
CFO LTM201,661898160-71201181
CFO 3Y Avg1211,350665143-120268206

Growth & Margins

SUPNJAZZNBIXACADAXSMAMRXMedian
NameSupernus.Jazz Pha.Neurocri.ACADIA P.Axsome T.Amneal P. 
Rev Chg LTM24.9%12.6%34.4%11.8%56.9%9.3%18.7%
Rev Chg 3Y Avg9.9%7.0%26.5%29.3%62.1%10.5%18.5%
Rev Chg Q32.4%15.5%39.5%16.4%45.5%9.9%24.4%
QoQ Delta Rev Chg LTM6.9%3.7%8.8%4.0%9.6%2.4%5.4%
Op Inc Chg LTM-177.9%65.5%61.5%-4.4%12.2%26.2%19.2%
Op Inc Chg 3Y Avg9.2%25.3%46.0%136.4%-9.1%28.2%26.7%
Op Mgn LTM-6.7%22.1%23.9%7.6%-23.5%15.4%11.5%
Op Mgn 3Y Avg3.5%17.4%23.2%6.3%-51.8%13.5%9.9%
QoQ Delta Op Mgn LTM-1.5%1.6%-1.9%0.2%1.4%0.8%0.5%
CFO/Rev LTM2.4%36.1%26.6%14.1%-9.2%6.4%10.3%
CFO/Rev 3Y Avg18.4%31.9%24.7%13.9%-30.3%9.5%16.1%
FCF/Rev LTM2.3%28.5%25.7%4.5%-9.3%-0.4%3.4%
FCF/Rev 3Y Avg18.3%28.3%23.4%7.4%-30.5%5.2%12.8%

Valuation

SUPNJAZZNBIXACADAXSMAMRXMedian
NameSupernus.Jazz Pha.Neurocri.ACADIA P.Axsome T.Amneal P. 
Mkt Cap2.515.615.74.810.75.68.1
P/S3.03.44.74.213.81.83.8
P/Op Inc-45.615.319.555.7-58.511.613.5
P/EBIT-21.117.419.255.7-57.513.015.2
P/E-23.016.622.312.6-55.935.414.6
P/CFO127.09.417.530.0-150.227.722.6
Total Yield-4.3%6.0%4.5%7.9%-1.8%2.8%3.7%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg7.2%14.3%4.3%2.2%-2.4%6.4%5.3%
D/E0.00.30.00.00.00.50.0
Net D/E-0.10.10.0-0.2-0.00.5-0.0

Returns

SUPNJAZZNBIXACADAXSMAMRXMedian
NameSupernus.Jazz Pha.Neurocri.ACADIA P.Axsome T.Amneal P. 
1M Rtn-7.2%-5.6%-3.6%-2.7%-2.9%-5.5%-4.6%
3M Rtn-2.7%3.5%-5.0%30.0%-11.0%26.8%0.4%
6M Rtn-19.2%35.6%21.5%26.4%27.3%31.7%26.9%
12M Rtn-4.2%92.8%10.9%9.9%66.1%82.6%38.5%
3Y Rtn37.1%77.6%41.6%1.6%162.4%356.5%59.6%
1M Excs Rtn-7.0%-3.9%-2.7%-1.6%-1.8%-3.6%-3.2%
3M Excs Rtn-7.3%-1.1%-9.6%25.4%-15.6%22.3%-4.2%
6M Excs Rtn-33.7%21.1%7.0%11.9%12.8%17.2%12.4%
12M Excs Rtn-22.9%74.1%-7.9%-8.8%47.4%63.9%19.8%
3Y Excs Rtn-34.8%-1.1%-27.4%-67.1%88.5%254.4%-14.2%

Comparison Analyses

null

FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA211964  QELBREEviloxazine hydrochloridecapsule, extended release402202113.7%1.9%20.4%35.6%62.9%
NDA209410  OSMOLEX ERamantadine hydrochloridetablet, extended release216201846.3%16.8%2.0%-37.4%13.5%
NDA208944  GOCOVRIamantadine hydrochloridecapsule, extended release8242017-13.2%-14.6%-1.0%-41.9%-3.3%
NDA201635  TROKENDI XRtopiramatecapsule, extended release81620137.2%35.5%35.5%162.7%555.6%
NDA202810  OXTELLAR XRoxcarbazepinetablet, extended release10192012-43.3%-59.1%-48.4%-39.2%235.6%
Collapse to Preview
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA211964  QELBREEviloxazine hydrochloridecapsule, extended release402202113.7%1.9%20.4%35.6%62.9%
NDA209410  OSMOLEX ERamantadine hydrochloridetablet, extended release216201846.3%16.8%2.0%-37.4%13.5%
NDA208944  GOCOVRIamantadine hydrochloridecapsule, extended release8242017-13.2%-14.6%-1.0%-41.9%-3.3%
NDA201635  TROKENDI XRtopiramatecapsule, extended release81620137.2%35.5%35.5%162.7%555.6%
NDA202810  OXTELLAR XRoxcarbazepinetablet, extended release10192012-43.3%-59.1%-48.4%-39.2%235.6%

Clinical Pipeline

Drug CandidateIndicationPhase 3 TrialsEst. Primary Completion
Viloxazine extended-release (SPN-812)Attention-Deficit/Hyperactivity Disorder1Sep 2026
Active Phase 3 studies led by the company. Source: ClinicalTrials.gov · Updated 8/28/2026

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Single Segment719662608667 
APOKYN    99
GOCOVRI    10
Other    33
Oxtellar XR    111
Qelbree    10
Royalty, licensing and other revenues    12
Trokendi XR    305
Total719662608667580


Net Income by Segment
$ Mil202520242023
Single Segment-39741
Total-39741


Price Behavior

Price Behavior
Market Price$43.53 
Market Cap ($ Bil)2.5 
First Trading Date05/01/2012 
Distance from 52W High-23.6% 
   50 Days200 Days
DMA Price$46.54$48.46
DMA Trenddownindeterminate
Distance from DMA-6.5%-10.2%
 3M1YR
Volatility35.3%35.6%
Downside Capture-80.9720.44
Upside Capture-76.7711.13
Correlation (SPY)-14.6%15.3%
SUPN Betas & Captures as of 8/31/2026

 1M2M3M6M1Y3Y
Beta-1.06-0.68-0.410.470.430.51
Up Beta-1.35-1.58-0.530.850.880.62
Down Beta2.691.750.961.050.690.43
Up Capture-106%-97%-79%-9%9%19%
Bmk +ve Days10213268138427
Stock +ve Days8172652120380
Down Capture-176%-79%-98%46%25%72%
Bmk -ve Days11213259113324
Stock -ve Days12243572126362

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SUPN
SUPN-4.2%35.6%-0.06-
Sector ETF (XLV)26.5%16.0%1.2827.8%
Equity (SPY)19.7%12.8%1.1315.3%
Gold (GLD)24.6%29.2%0.7510.4%
Commodities (DBC)44.1%20.4%1.69-18.6%
Real Estate (VNQ)9.1%13.6%0.3916.5%
Bitcoin (BTCUSD)-26.9%43.8%-0.594.2%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SUPN
SUPN10.9%35.3%0.36-
Sector ETF (XLV)6.6%15.1%0.2526.6%
Equity (SPY)12.8%17.2%0.5728.9%
Gold (GLD)19.1%18.8%0.824.6%
Commodities (DBC)10.7%19.5%0.43-0.7%
Real Estate (VNQ)1.7%18.9%-0.0126.1%
Bitcoin (BTCUSD)10.6%52.6%0.3813.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with SUPN
SUPN7.6%43.8%0.32-
Sector ETF (XLV)10.8%16.7%0.5331.4%
Equity (SPY)15.3%17.9%0.7231.1%
Gold (GLD)12.4%16.3%0.620.7%
Commodities (DBC)7.9%18.1%0.358.6%
Real Estate (VNQ)4.8%20.7%0.1922.6%
Bitcoin (BTCUSD)64.0%66.2%1.049.2%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date8142026
Short Interest: Shares Quantity4.1 Mil
Short Interest: % Change Since 7312026-13.9%
Average Daily Volume1.5 Mil
Days-to-Cover Short Interest2.8 days
Basic Shares Quantity58.1 Mil
Short % of Basic Shares7.1%

Earnings Returns History

Updated 9/3/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/3/20263.1%6.7%-0.9%
5/5/20264.6%2.7%-9.1%
2/24/20265.7%2.4%-6.1%
11/4/2025-17.4%-19.1%-19.9%
7/22/20250.9%2.4%30.6%
2/25/2025-2.7%-3.5%-1.5%
11/4/20240.1%5.5%7.1%
8/6/202414.5%20.7%23.3%
...
SUMMARY STATS   
# Positive1198
# Negative7910
Median Positive2.5%5.3%8.5%
Median Negative-4.2%-5.1%-5.4%
Max Positive14.5%21.6%30.6%
Max Negative-17.4%-19.1%-19.9%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/3/20263.1%6.7%-0.9%
5/5/20264.6%2.7%-9.1%
2/24/20265.7%2.4%-6.1%
11/4/2025-17.4%-19.1%-19.9%
7/22/20250.9%2.4%30.6%
2/25/2025-2.7%-3.5%-1.5%
11/4/20240.1%5.5%7.1%
8/6/202414.5%20.7%23.3%
5/8/2024-4.2%-8.2%-16.1%
2/27/20241.3%-1.1%9.9%
11/8/202311.1%21.6%14.4%
8/8/2023-7.2%-3.3%-8.7%
5/9/20231.5%-2.8%-1.6%
5/9/2022-2.0%4.1%7.0%
2/28/2022-7.0%-5.9%1.8%
11/4/20212.0%5.3%-4.7%
8/4/2021-2.2%-9.7%1.8%
11/4/20202.5%-5.1%-2.1%
SUMMARY STATS   
# Positive1198
# Negative7910
Median Positive2.5%5.3%8.5%
Median Negative-4.2%-5.1%-5.4%
Max Positive14.5%21.6%30.6%
Max Negative-17.4%-19.1%-19.9%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/03/202610-Q
03/31/202605/05/202610-Q
12/31/202503/02/202610-K
09/30/202511/06/202510-Q
06/30/202508/05/202510-Q
03/31/202505/06/202510-Q
12/31/202402/25/202510-K
09/30/202411/04/202410-Q
06/30/202408/06/202410-Q
03/31/202405/08/202410-Q
12/31/202302/27/202410-K
09/30/202311/08/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202203/09/202310-K
09/30/202211/09/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/03/202610-Q
03/31/202605/05/202610-Q
12/31/202503/02/202610-K
09/30/202511/06/202510-Q
06/30/202508/05/202510-Q
03/31/202505/06/202510-Q
12/31/202402/25/202510-K
09/30/202411/04/202410-Q
06/30/202408/06/202410-Q
03/31/202405/08/202410-Q
12/31/202302/27/202410-K
09/30/202311/08/202310-Q
06/30/202308/08/202310-Q
03/31/202305/09/202310-Q
12/31/202203/09/202310-K
09/30/202211/09/202210-Q
06/30/202208/08/202210-Q
03/31/202205/12/202210-Q
12/31/202104/13/202210-K
09/30/202111/05/202110-Q
06/30/202108/06/202110-Q
03/31/202105/07/202110-Q
12/31/202003/08/202110-K
09/30/202011/06/202010-Q
06/30/202008/17/202010-Q
03/31/202005/15/202010-Q
12/31/201902/28/202010-K
09/30/201911/08/201910-Q

Insider Activity

Updated 8/14/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202649.607,250359,621845,431Form
2Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202650.3050,0002,514,886857,274Form
3Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202650.2850,0002,513,925856,947Form
4Khattar, Jack APresident, CEOthe KBT TrustSell316202650.3735,0001,763,12448,264,272Form
5Hudson, Frederick MDirectSell316202650.615,369271,7253,057,502Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202649.607,250359,621845,431Form
2Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202650.3050,0002,514,886857,274Form
3Bhatt, Padmanabh PSr. VP of IP, CSODirectSell318202650.2850,0002,513,925856,947Form
4Khattar, Jack APresident, CEOthe KBT TrustSell316202650.3735,0001,763,12448,264,272Form
5Hudson, Frederick MDirectSell316202650.615,369271,7253,057,502Form
6Gemayel, GeorgesDirectSell309202653.008,787465,7111,445,681Form
7Gemayel, GeorgesDirectSell309202653.7110,000537,1001,512,420Form
8Sensenig, BethanyDirectSell223202651.014,475  Form
9Mottola, FrankSVP, Chief Tech. Ops. OfficerDirectSell1222202550.4120,0001,008,150781,115Form
10Bhatt, Padmanabh PSr. VP of IP, CSODirectSell1219202544.4471031,552644,736Form
11Khattar, Jack APresident, CEODirectSell1010202550.5759,9003,029,33661,020,545Form
12Newhall, Charles W IiiDirectSell1010202550.7725,0001,269,2345,312,709Form
13Khattar, Jack APresident, CEODirectSell1003202548.061,90491,50655,808,858Form
14Khattar, Jack APresident, CEODirectSell1002202548.0740,1731,931,11655,803,021Form
15Khattar, Jack APresident, CEODirectSell1001202548.258,588414,37155,355,198Form
16Khattar, Jack APresident, CEODirectSell930202548.0210,235491,48554,951,015Form
17Khattar, Jack APresident, CEODirectSell924202547.2329,5131,393,89953,883,904Form
18Khattar, Jack APresident, CEODirectSell923202547.0216,587779,92152,777,881Form
19Mottola, FrankSVP, Chief Tech. Ops. OfficerDirectSell915202545.875,000229,350710,802Form
20Khattar, Jack APresident, CEODirectSell909202546.296,322292,64551,473,693Form
21Khattar, Jack APresident, CEODirectSell908202546.0155,5782,557,14451,081,728Form
22Khattar, Jack APresident, CEODirectSell829202545.1224,1501,089,64849,299,601Form
23Khattar, Jack APresident, CEODirectSell829202545.0510,650479,78248,564,080Form
24Newhall, Charles W IiiDirectSell829202545.013,588161,4965,835,276Form
25Mottola, FrankSVP, Quality, GMP, Ops, ITDirectSell827202544.5114,000623,140689,727Form
26Newhall, Charles W IiiDirectSell827202545.001,00045,0005,995,440Form
27Khattar, Jack APresident, CEODirectSell827202545.001,00045,00048,215,655Form
28Newhall, Charles W IiiDirectSell826202545.001,41263,5406,040,440Form
29Dec, Timothy CSenior Vice-President & CFODirectSell826202544.4911,780524,09255,435Form
30Khattar, Jack APresident, CEODirectSell826202545.001,50067,50048,188,160Form
31Sensenig, BethanyDirectSell818202542.255,369  Form
32Hudson, Frederick MDirectSell818202542.267,457315,1331,956,934Form
33Khattar, Jack APresident, CEODirectSell808202542.02140,0005,883,36043,292,410Form

Investor Activity (13F)

Updated Sep 5, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Bruce & Co., Inc.$5.2 Mil1.5%41ADD +21.8%13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Bruce & Co., Inc.$5.2 Mil1.5%41ADD +21.8%13F
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Bruce & Co., Inc.$5.2 Mil1.5%41ADD +21.8%13F
Core Cache Last Updated: 9/4/2026