OnKure Therapeutics (OKUR)


Market Price (11/6/2026): $2.52 | Market Cap: $103.8 MilSector: Health Care | Industry: Biotechnology

OnKure Therapeutics (OKUR)


Market Price (11/6/2026): $2.52
Market Cap: $103.8 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -129%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.

Weak multi-year price returns
2Y Excs Rtn is -120%, 3Y Excs Rtn is -170%

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -66 Mil

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -54%

Key risks
OKUR key risks include [1] a high cash burn rate relative to its market capitalization creating significant financial pressure and [2] heavy reliance on a limited number of product candidates, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -129%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -120%, 3Y Excs Rtn is -170%
3 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -66 Mil
5 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -54%
6 Key risks
OKUR key risks include [1] a high cash burn rate relative to its market capitalization creating significant financial pressure and [2] heavy reliance on a limited number of product candidates, Show more.

OKUR in ETFs

Weight = OKUR's share of each fund

VTI0.00%
IWM0.00%
IWN0.00%
VTWO0.00%
DFAS0.00%

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 11/5/2026

OnKure Therapeutics (OKUR) stock has lost about 35% since 7/31/2026 because of the following key factors:

1. Significant Analyst Price Target Reduction. In mid-August 2026, Oppenheimer lowered its price target for OnKure Therapeutics (OKUR) to $14.00 from a previous target of $30.00, representing a substantial reduction of over 50%. This downgrade by a key analyst likely sent a negative signal to investors regarding the company's valuation and future prospects.

2. Deprioritization of Key Pipeline Candidate. OnKure Therapeutics announced in its Q1 2026 financial results that it would not independently pursue further clinical development of OKI-219, a highly selective PI3KαH1047 mutant-specific inhibitor, at that time. While the company stated it planned to report data from its PIKture-01 trial by the end of 2026, the decision to deprioritize independent development of a clinical-stage asset could have raised concerns among investors about the company's pipeline strategy and future potential.

Show more
Updated on 11/5/2026

OnKure Therapeutics (OKUR) stock has lost about 35% since 7/31/2026 because of the following key factors:

1. Significant Analyst Price Target Reduction. In mid-August 2026, Oppenheimer lowered its price target for OnKure Therapeutics (OKUR) to $14.00 from a previous target of $30.00, representing a substantial reduction of over 50%. This downgrade by a key analyst likely sent a negative signal to investors regarding the company's valuation and future prospects.

2. Deprioritization of Key Pipeline Candidate. OnKure Therapeutics announced in its Q1 2026 financial results that it would not independently pursue further clinical development of OKI-219, a highly selective PI3KαH1047 mutant-specific inhibitor, at that time. While the company stated it planned to report data from its PIKture-01 trial by the end of 2026, the decision to deprioritize independent development of a clinical-stage asset could have raised concerns among investors about the company's pipeline strategy and future potential.

3. Increasing Operating Expenses Despite No Revenue. As a clinical-stage biopharmaceutical company, OnKure Therapeutics continues to incur substantial research and development (R&D) and general and administrative (G&A) expenses without generating product revenue. In fiscal Q3 2026 (ended September 30, 2026), the company's net loss widened to $17.8 million compared to $14.7 million in fiscal Q3 2025. R&D expenses increased to $15.1 million in fiscal Q3 2026 from $11.9 million in the prior year, driven primarily by outsourced preclinical R&D, manufacturing, and consulting costs, indicating a higher cash burn rate.

4. Distant Clinical Milestones for Lead Programs. OnKure's lead next-generation PI3Kα pan-mutant-selective inhibitor candidates, OKI-355 for vascular anomalies and OKI-345 for breast cancer, are still in preclinical stages with Investigational New Drug (IND) submissions planned for the first half of 2027. This indicates a prolonged period before these programs could generate significant clinical data, leading to investor impatience or a re-evaluation of the company's timeline to potential commercialization, especially in a market where near-term catalysts are often favored for clinical-stage companies.

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Stock Movement Drivers

Fundamental Drivers

The -33.9% change in OKUR stock from 7/31/2026 to 11/5/2026 was primarily driven by a -72.6% change in the company's Shares Outstanding (Mil).
(LTM values as of)731202611052026Change
Stock Price ($)3.822.52-33.9%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)1450-72.6%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2026 to 11/5/2026
ReturnCorrelation
OKUR-33.9% 
Market (SPY)-1.9%22.4%
Sector (XLV)13.8%21.4%

Fundamental Drivers

The -52.1% change in OKUR stock from 4/30/2026 to 11/5/2026 was primarily driven by a -72.8% change in the company's Shares Outstanding (Mil).
(LTM values as of)430202611052026Change
Stock Price ($)5.272.52-52.1%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)1450-72.8%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 11/5/2026
ReturnCorrelation
OKUR-52.1% 
Market (SPY)2.3%15.4%
Sector (XLV)27.2%13.8%

Fundamental Drivers

The -25.5% change in OKUR stock from 10/31/2025 to 11/5/2026 was primarily driven by a -72.9% change in the company's Shares Outstanding (Mil).
(LTM values as of)1031202511052026Change
Stock Price ($)3.392.52-25.5%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)1450-72.9%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 11/5/2026
ReturnCorrelation
OKUR-25.5% 
Market (SPY)8.4%22.4%
Sector (XLV)29.8%12.2%

Fundamental Drivers

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Market Drivers

10/31/2023 to 11/5/2026
ReturnCorrelation
OKUR  
Market (SPY)81.3%23.0%
Sector (XLV)55.5%23.0%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
OKUR Return----54%-66%-13%-86%
Peers Return-19%-24%132%-9%139%45%349%
S&P 500 Return27%-19%24%23%16%12%105%

Monthly Win Rates [3]
OKUR Win Rate---0%25%36% 
Peers Win Rate44%50%62%48%63%48% 
S&P 500 Win Rate75%42%67%75%67%45% 

Max Drawdowns [4]
OKUR Max Drawdown-----80%-60% 
Peers Max Drawdown-54%-50%-43%-46%-44%-39% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: LLY, RLAY, RVMD, OLMA.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 11/5/2026 (YTD)

About OnKure Therapeutics (OKUR)

OnKure Therapeutics (OKUR) is a clinical-stage biopharmaceutical company dedicated to discovering and developing precision medicines for various cancers. Its primary objective is to address oncology areas where current therapies are insufficient, focusing on improving clinical outcomes for patients by targeting the fundamental biological drivers of these diseases.

The company employs a sophisticated drug design platform that integrates structure-based and computational chemistry techniques. This methodology enables OnKure to build a robust pipeline of small-molecule drugs, each designed to selectively inhibit specific genetic mutations identified as key drivers of cancer. Essentially, OnKure aims to provide highly targeted therapeutic solutions for cancer patients with these specific mutational profiles.

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  • A clinical-stage Genentech (Roche) for precision cancer therapies, driven by computational design.
  • Recursion Pharmaceuticals, but for computationally-designed small-molecule drugs specifically targeting cancer.
  • Vertex Pharmaceuticals for precision oncology, leveraging advanced computational chemistry.
  • AI Analysis | Feedback

    • OK-2268: A selective Class I HDAC inhibitor in clinical development for various cancers.
    • OK-1144: A selective PI3Kα H1047R inhibitor in clinical development for solid tumors with specific mutations.
    • Discovery Programs: Early-stage research and development efforts for novel small-molecule drug candidates targeting cancer.

    AI Analysis | Feedback

    As a clinical-stage biopharmaceutical company, OnKure Therapeutics (OKUR) is primarily focused on the discovery and development of precision medicines for cancer. The company does not currently have any commercialized products approved for sale on the market.

    Therefore, OnKure Therapeutics does not have "major customers" in the traditional sense of companies or individuals purchasing its products or services at this stage of its business operations.

    AI Analysis | Feedback

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    Nicholas A. Saccomano, Ph.D., President & Chief Executive Officer

    Dr. Saccomano is a biopharmaceutical professional with nearly 35 years of experience leading pharmaceutical research and development across multiple therapeutic areas. Prior to joining OnKure, he served as the Chief Science Officer and Site Head at Pfizer's Boulder facility, where he led a team of 170 research scientists focused on small molecule drug programs. He oversaw the discovery and progression of several central nervous system drugs, including ziprasidone (Geodon®), donepezil (Aricept®), and varenicline (Chantix®). Dr. Saccomano also held the position of Chief Science Officer at Array BioPharma Inc., where he was instrumental in creating and advancing ten clinical-stage compounds, leading to seven drug approvals. Furthermore, he served as Chief Technology Officer at SomaLogic Inc., managing scientific and technical teams focused on advancing the company's proteomic platform.

    Jason Leverone, CPA, Chief Financial Officer

    Mr. Leverone brings over 25 years of strategic finance and operational experience, with more than 19 years in the life sciences sector. Before his role at OnKure, he served as Chief Financial Officer and Secretary of miRagen Therapeutics, Inc., a publicly traded biotechnology company that was acquired in 2021 (merged with Viridian Therapeutics, Inc. in 2020). At miRagen, he played key roles in public offerings, strategic license transactions, and mergers and acquisitions. Prior to miRagen, Mr. Leverone was the Senior Director of Finance and Controller for Replidyne, Inc., another publicly traded biotechnology company acquired in 2009. He also served as Corporate Controller for CreekPath Systems, Inc., a private international software development company. He is a Certified Public Accountant (CPA) and began his professional career in public accounting at Ernst and Young LLP and Arthur Andersen LLP.

    Samuel Agresta, M.D., M.P.H., Chief Medical Officer

    Dr. Agresta serves as the Chief Medical Officer for OnKure Therapeutics.

    Dylan Hartley, Ph.D., Chief Scientific Officer

    Dr. Hartley holds the position of Chief Scientific Officer at OnKure Therapeutics.

    Rogan Nunn, J.D., General Counsel & Secretary

    Mr. Nunn is the General Counsel and Secretary for OnKure Therapeutics.

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    Key Risks to OnKure Therapeutics (OKUR)

    1. Financial Viability and Funding Needs: OnKure Therapeutics faces substantial financial risks, including a limited cash runway and ongoing significant net losses since its inception, with no foreseeable profitability from product sales. The company's management has expressed substantial doubt about its ability to continue as a going concern. Its continued operations and advancement of clinical trials are highly dependent on securing additional funding on favorable terms and in a timely manner.
    2. Clinical Development and Regulatory Approval: As a clinical-stage biopharmaceutical company, OnKure's success hinges on the positive outcomes of its clinical trials, particularly for its lead asset, OKI-219. There is no guarantee that ongoing or future clinical trials will yield positive results, nor that the company will overcome substantial regulatory hurdles to obtain timely approvals for its product candidates. Negative clinical results, delays in advancing pipeline candidates, or failure to meet regulatory requirements could significantly impede commercialization efforts.
    3. Competition and Intellectual Property: The biopharmaceutical market is intensely competitive, and OnKure Therapeutics operates in a field with many established and emerging companies developing similar cancer therapies. The company's ability to compete effectively and protect its intellectual property and proprietary technologies is crucial for its long-term success. The presence of competing product candidates and therapies could limit the market potential of OnKure's pipeline.
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    OnKure Therapeutics (NASDAQ: OKUR) is a clinical-stage biopharmaceutical company focused on developing precision medicines for cancers. Its lead product candidate is OKI-219, a selective inhibitor of phosphoinositide 3 kinase alpha (PI3Kα) harboring the H1047R mutation, currently in Phase 1 clinical trials for solid tumors, including breast cancer.

    The addressable market for OnKure's main product, OKI-219, primarily focuses on patients with PIK3CA H1047R-mutated breast cancer and potentially other solid tumors and vascular malformations.

    For breast cancer, the estimated addressable market is:

    • United States (US): Approximately 140,000 patients with HR+/HER2- breast cancer have a PI3Kα mutation per year. The H1047R mutation is one of the most prevalent PIK3CA hotspot mutations, accounting for about 35%-41% of PIK3CA mutations in ER+/HER2- breast cancer and 43%-61% in HER2+ breast cancer. Based on these percentages, the number of patients with the H1047R mutation within the PI3Kα-mutated HR+/HER2- breast cancer population in the US is estimated to be tens of thousands annually.
    • Global: The World Health Organization reported 2.3 million women diagnosed with breast cancer globally in 2020. PIK3CA mutations are identified in approximately 36% of all breast cancers. With the H1047R mutation being one of the most common PIK3CA mutations, often representing around 45% of all PIK3CA mutations across various studies, the global annual incidence of H1047R-mutated breast cancer is estimated to be in the hundreds of thousands of patients.

    The broader market for PI3K & AKT & mTOR Pathway Inhibitors for Breast Cancer is estimated to be approximately $1,500 million globally in 2025, with a projected Compound Annual Growth Rate (CAGR) of around 18% over the forecast period of 2025-2033. OnKure Therapeutics highlights a "sizable commercial opportunity" specifically in PI3Kα-mutated HR+/HER2- and HER2+ breast cancer.

    Additionally, OnKure is advancing programs in vascular malformations. A competitor's PI3Kα inhibitor is noted to have the potential to address an estimated 170,000 patients with vascular anomalies driven by a PI3Kα mutation per year in the United States.

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    Here are 3-5 expected drivers of future revenue growth for OnKure Therapeutics (OKUR) over the next 2-3 years:

    1. Advancement of Lead Clinical Candidate (OKI-219): Successful progression and positive clinical data readouts from the PIKture-01 trial for OKI-219 are a primary driver. OnKure Therapeutics' lead product candidate, OKI-219, a selective inhibitor of phosphoinositide 3 kinase alpha (PI3Kα) harboring the H1047R mutation, is currently in Phase 1 clinical trials for solid tumors, including breast cancer. Completion of enrollment in Parts A and B, and ongoing dosing in the triplet Part E of the PIKture-01 trial, with expected updated safety, tolerability, and clinical activity data in March 2026, are critical milestones. Positive results could validate the drug's potential, attract further investment, and significantly enhance its value for future partnerships or commercialization efforts.

    2. Development and Progression of Next-Generation PI3Kα Pan-Mutant Inhibitor: The planned announcement and subsequent development of a next-generation PI3Kα pan-mutant inhibitor candidate, especially for HR+ metastatic breast cancer, represents a significant expansion of OnKure's pipeline and a potential future market opportunity. The company anticipates providing additional details on this PI3Kα pan-mutant program in 2026. This new candidate, if successfully advanced, could lead to new collaborations and future revenue streams by addressing a large and underserved patient population.

    3. Strategic Collaborations and Licensing Agreements: As a clinical-stage biopharmaceutical company with a pre-commercial status, OnKure Therapeutics' business model relies significantly on collaborations with larger pharmaceutical companies, licensing agreements, and milestone payments. The company actively seeks strategic partnerships to accelerate the development and potential commercialization of its innovative small-molecule therapies. Such agreements typically include upfront payments and milestone payments upon achieving specific development or regulatory goals, which would directly contribute to revenue growth over the next 2-3 years.

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    Share Issuance

    • OnKure Therapeutics, Inc. filed a Follow-on Equity Offering in the amount of approximately $16.0 million on November 7 (likely 2024 or 2025).
    • In connection with the merger that created OnKure Therapeutics (closing October 4, 2024), pre-merger OnKure, Inc. stockholders were expected to own approximately 69.4% of the combined company, and pre-merger Reneo Pharmaceuticals stockholders were expected to own approximately 30.6% on a fully-diluted basis.

    Inbound Investments

    • Reneo Pharmaceuticals, Inc. (the predecessor company to OnKure Therapeutics) entered into a subscription agreement for a $65 million Private Investment in Public Equity (PIPE) financing, which was expected to close concurrently with the merger in October 2024. This investment was made by a group of institutional investors including Acorn Bioventures, Cormorant Asset Management, Deep Track Capital, Perceptive Advisors, Samsara BioCapital, Surveyor Capital (a Citadel company), and Vestal Point Capital.
    • The merger itself, which combined Reneo Pharmaceuticals, Inc. and OnKure, Inc. (a private company), formed the current public entity OnKure Therapeutics, Inc. The combined company was expected to have approximately $120 million of cash resources at closing.

    Peer Outperformance in Biotechnology

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    Share of Biotechnology constituents that OKUR has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
    1Y
    55%
    of 452 industry peers · -15.8% return
    3Y
    —
    insufficient peer history
    5Y
    —
    insufficient peer history
    null
    Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is OKUR's own industry. Use this to see which corners of the sector have carried the returns.
    Industry Names 1Y med3Y med5Y med Top 3 by 5Y
    Health Care Distributors 6 7.6%56.6%93.6% CAH 498% · MCK 396% · COR 181%
    Health Care Services 20 33.8%28.8%6.1% HIMS 189% · RDNT 125% · DGX 100%
    Health Care Facilities 25 13.9%27.4%-1.4% THC 280% · NHC 210% · EHC 186%
    Managed Health Care 8 47.9%1.6%-2.2% OSCR 95% · HQY 52% · ELV 10%
    Health Care Equipment 50 11.0%17.8%-17.6% UFPT 355% · GKOS 286% · PLSE 127%
    Pharmaceuticals 61 -12.9%10.6%-37.3% LQDA 977% · XERS 571% · KNSA 500%
    Health Care Supplies 11 23.9%17.0%-40.1% LNTH 248% · HAE 66% · MMSI 29%
    Life Sciences Tools & Services 108 -8.1%-18.9%-74.5% AXGN 255% · NTRA 214% · MEDP 181%
    Biotechnology ← 364 -25.8%-36.1%-82.0% ELVN 1073% · TRVI 995% · DNTH 956%
    Health Care Technology 21 -21.4%-50.4%-82.8% VEEV -3% · DOCS -51%
    Median of constituents with a full price history over each window. Top names are limited to companies above $2B market cap.

    Latest Trefis Analyses

    TitleDate
    0DASHBOARDS 
    1OnKure Therapeutics Earnings Notes12/16/2025
    Title
    0ARTICLES

    Recent Active Movers

    Peer Comparisons

    Peers to compare with:

    Financials

    OKURLLYRLAYRVMDOLMAMedian
    NameOnKure T.Eli LillyRelay Th.Revoluti.Olema Ph. 
    Mkt Price2.521,351.0017.11183.016.7217.11
    Mkt Cap0.11,205.03.739.30.73.7
    Rev LTM086,46210198010
    Op Inc LTM-6644,315-320-1,685-221-221
    FCF LTM-4811,689-214-1,441-165-165
    FCF 3Y Avg-435,283-248-923-128-128
    CFO LTM-4830,645-214-1,431-165-165
    CFO 3Y Avg-4317,580-248-911-128-128

    Growth & Margins

    OKURLLYRLAYRVMDOLMAMedian
    NameOnKure T.Eli LillyRelay Th.Revoluti.Olema Ph. 
    Rev Chg LTM-45.5%23.9%--34.7%
    Rev Chg 3Y Avg-39.4%-17.9%--10.7%
    Rev Chg Q-38.6%---38.6%
    QoQ Delta Rev Chg LTM-8.5%0.0%--4.3%
    Op Inc Chg LTM2.3%67.9%2.1%-62.5%-40.7%2.1%
    Op Inc Chg 3Y Avg-68.3%4.0%-66.1%-29.9%-12.9%
    Op Mgn LTM-51.3%-3,094.6%-853.0%--853.0%
    Op Mgn 3Y Avg-43.7%-3,652.1%---1,804.2%
    QoQ Delta Op Mgn LTM-1.5%-95.2%---46.8%
    CFO/Rev LTM-35.4%-2,067.8%-724.5%--724.5%
    CFO/Rev 3Y Avg-25.7%-2,614.6%---1,294.4%
    FCF/Rev LTM-13.5%-2,067.8%-729.3%--729.3%
    FCF/Rev 3Y Avg-6.3%-2,623.4%---1,308.6%

    Valuation

    OKURLLYRLAYRVMDOLMAMedian
    NameOnKure T.Eli LillyRelay Th.Revoluti.Olema Ph. 
    Mkt Cap0.11,205.03.739.30.73.7
    P/S-13.9362.3199.1-199.1
    P/Op Inc-1.927.2-11.7-23.3-3.2-3.2
    P/EBIT-2.027.2-11.7-22.0-3.2-3.2
    P/E-2.043.7-12.8-21.0-3.4-3.4
    P/CFO-2.639.3-17.5-27.5-4.3-4.3
    Total Yield-49.2%2.8%-7.9%-4.9%-29.0%-7.9%
    Dividend Yield0.0%0.5%0.0%0.0%0.0%0.0%
    FCF Yield 3Y Avg-0.6%-20.5%-6.4%-20.9%-13.5%
    D/E0.00.00.00.00.00.0
    Net D/E-1.30.0-0.2-0.1-0.7-0.2

    Returns

    OKURLLYRLAYRVMDOLMAMedian
    NameOnKure T.Eli LillyRelay Th.Revoluti.Olema Ph. 
    1M Rtn2.4%16.7%-8.7%-8.4%-15.1%-8.4%
    3M Rtn-39.3%13.5%-13.4%-7.5%-43.0%-13.4%
    6M Rtn-36.4%39.0%36.8%28.4%-55.6%28.4%
    12M Rtn-16.0%46.8%161.2%208.4%-15.4%46.8%
    3Y Rtn-86.5%131.7%110.5%749.6%-55.3%110.5%
    1M Excs Rtn8.7%15.1%-3.2%-7.4%-13.9%-3.2%
    3M Excs Rtn-38.2%15.0%-12.6%-9.9%-43.3%-12.6%
    6M Excs Rtn-41.1%34.3%31.9%23.5%-60.3%23.5%
    12M Excs Rtn-32.2%36.5%135.8%198.5%-31.5%36.5%
    3Y Excs Rtn-169.7%66.5%75.4%738.4%-132.3%66.5%

    Comparison Analyses

    null

    Financials

    Segment Financials

    Revenue by Segment
    $ Mil202420232022
    Clinical research000
    Total000


    Operating Income by Segment
    $ Mil20252024
    Clinical research-63-54
    Total-63-54


    Net Income by Segment
    $ Mil20252024
    Clinical research-60-53
    Total-60-53


    Assets by Segment
    $ Mil202420232022
    Clinical research1153616
    Total1153616


    Price Behavior

    Price Behavior
    Market Price$2.52 
    Market Cap ($ Bil)0.1 
    First Trading Date10/07/2024 
    Distance from 52W High-52.1% 
       50 Days200 Days
    DMA Price$2.80$3.60
    DMA Trenddowndown
    Distance from DMA-9.8%-29.9%
     3M1YR
    Volatility55.9%69.5%
    Downside Capture240.72128.33
    Upside Capture-36.2787.88
    Correlation (S&P 500)16.2%22.6%
    OKUR Betas & Captures as of 10/31/2026

     1M2M3M6M1Y3Y
    Beta-0.080.961.070.711.21-0.24
    Up Beta6.933.113.421.142.200.04
    Down Beta-2.90-1.27-0.730.340.800.07
    Up Capture39%20%0%-6%70%3%
    Bmk +ve Days12182862130427
    Stock +ve Days9152449108206
    Down Capture92%243%205%144%115%103%
    Bmk -ve Days10253664121325
    Stock -ve Days12273972134292

    [1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
    Based On 1-Year Data
    Annualized
    Return
    Annualized
    Volatility
    Sharpe
    Ratio
    Correlation
    with OKUR
    OKUR-18.6%69.5%-0.02-
    Sector ETF (XLV)29.2%16.9%1.3312.4%
    Equity (SPY)9.5%13.6%0.4122.0%
    Gold (GLD)3.6%28.7%0.110.1%
    Commodities (DBC)37.7%21.2%1.40-5.8%
    Real Estate (VNQ)12.0%14.2%0.557.5%
    Bitcoin (BTCUSD)-20.8%43.3%-0.4213.6%

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    Based On 5-Year Data
    Annualized
    Return
    Annualized
    Volatility
    Sharpe
    Ratio
    Correlation
    with OKUR
    OKUR-32.9%69.9%-1.09-
    Sector ETF (XLV)8.6%15.4%0.3623.0%
    Equity (SPY)11.3%17.3%0.4823.0%
    Gold (GLD)17.5%19.1%0.742.0%
    Commodities (DBC)8.0%19.6%0.29-2.4%
    Real Estate (VNQ)1.2%18.9%-0.0517.4%
    Bitcoin (BTCUSD)5.9%51.5%0.299.0%

    Smart multi-asset allocation framework can stack odds in your favor. Learn How
    Based On 10-Year Data
    Annualized
    Return
    Annualized
    Volatility
    Sharpe
    Ratio
    Correlation
    with OKUR
    OKUR-18.1%69.9%-1.09-
    Sector ETF (XLV)12.2%16.8%0.6023.0%
    Equity (SPY)14.9%18.0%0.7023.0%
    Gold (GLD)12.0%16.5%0.592.0%
    Commodities (DBC)7.6%18.1%0.33-2.4%
    Real Estate (VNQ)5.7%20.7%0.2317.4%
    Bitcoin (BTCUSD)61.3%66.2%1.019.0%

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    Short Interest

    Short Interest: As Of Date10152026
    Short Interest: Shares Quantity1.4 Mil
    Short Interest: % Change Since 930202613.2%
    Average Daily Volume0.5 Mil
    Days-to-Cover Short Interest2.6 days
    Basic Shares Quantity49.9 Mil
    Short % of Basic Shares2.8%

    Earnings Returns History

    Updated 11/4/2026
    Expand for More
     Forward Returns
    Earnings Date1D Returns5D Returns21D Returns
    8/4/20261.5%-0.2%-13.7%
    5/5/2026-10.0%-25.0%-4.9%
    3/12/20267.4%24.4%26.4%
    11/6/2025-7.0%-0.6%5.4%
    8/12/202520.0%37.0%22.0%
    5/6/2025-11.2%-22.3%15.1%
    3/10/2025-0.2%-2.8%-38.1%
    SUMMARY STATS   
    # Positive324
    # Negative453
    Median Positive7.4%30.7%18.6%
    Median Negative-8.5%-2.8%-13.7%
    Max Positive20.0%37.0%26.4%
    Max Negative-11.2%-25.0%-38.1%
    Collapse to Preview
     Forward Returns
    Earnings Date1D Returns5D Returns21D Returns
    8/4/20261.5%-0.2%-13.7%
    5/5/2026-10.0%-25.0%-4.9%
    3/12/20267.4%24.4%26.4%
    11/6/2025-7.0%-0.6%5.4%
    8/12/202520.0%37.0%22.0%
    5/6/2025-11.2%-22.3%15.1%
    3/10/2025-0.2%-2.8%-38.1%
    SUMMARY STATS   
    # Positive324
    # Negative453
    Median Positive7.4%30.7%18.6%
    Median Negative-8.5%-2.8%-13.7%
    Max Positive20.0%37.0%26.4%
    Max Negative-11.2%-25.0%-38.1%

    SEC Filings

    Expand for More
    Report DateFiling DateFiling
    09/30/202611/04/202610-Q
    06/30/202608/04/202610-Q
    03/31/202605/05/202610-Q
    12/31/202503/12/202610-K
    09/30/202511/06/202510-Q
    06/30/202508/12/202510-Q
    03/31/202505/06/202510-Q
    12/31/202403/10/202510-K
    09/30/202411/07/202410-Q
    06/30/202408/26/2024424B3
    03/31/202406/21/2024S-4
    Collapse to Preview
    Report DateFiling DateFiling
    09/30/202611/04/202610-Q
    06/30/202608/04/202610-Q
    03/31/202605/05/202610-Q
    12/31/202503/12/202610-K
    09/30/202511/06/202510-Q
    06/30/202508/12/202510-Q
    03/31/202505/06/202510-Q
    12/31/202403/10/202510-K
    09/30/202411/07/202410-Q
    06/30/202408/26/2024424B3
    03/31/202406/21/2024S-4

    Insider Activity

    Updated 9/23/2026
    Expand for More
    #OwnerTitleHoldingActionFiling DatePriceSharesTransacted
    Value
    Value of
    Held Shares
    Form
    1Leverone, Jason AChief Financial OfficerDirectSell92320262.9730289855,023Form
    2Saccomano, Nicholas APresident and CEODirectSell92320262.978725933,192Form
    3Saccomano, Nicholas APresident and CEODirectSell62420264.408637849,445Form
    4Leverone, Jason AChief Financial OfficerDirectSell62420264.403031,33282,659Form
    5Leverone, Jason AChief Financial OfficerDirectSell32420264.163011,25166,504Form
    Collapse to Preview
    #OwnerTitleHoldingActionFiling DatePriceSharesTransacted
    Value
    Value of
    Held Shares
    Form
    1Leverone, Jason AChief Financial OfficerDirectSell92320262.9730289855,023Form
    2Saccomano, Nicholas APresident and CEODirectSell92320262.978725933,192Form
    3Saccomano, Nicholas APresident and CEODirectSell62420264.408637849,445Form
    4Leverone, Jason AChief Financial OfficerDirectSell62420264.403031,33282,659Form
    5Leverone, Jason AChief Financial OfficerDirectSell32420264.163011,25166,504Form
    6Saccomano, Nicholas APresident and CEODirectSell32420264.168635730,480Form
    7Saccomano, Nicholas APresident and CEODirectSell122320252.978725822,017Form
    8Leverone, Jason AChief Financial OfficerDirectSell122320252.9730289648,376Form
    9Saccomano, Nicholas APresident and CEODirectSell92420252.62882319,198Form
    10Leverone, Jason AChief Financial OfficerDirectSell92420252.6230379533,064Form

    Investor Activity (13F)

    Updated Nov 6, 2026
    13F holdings as of Mar 31, 2026 (Q1 2026)

    Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

    Active ManagerValue% of PortfolioTotal PositionsQoQFiling
    Acorn Capital Advisors, LLC$11.8 Mil3.3%22Hold13F
    Prosight Management, LP$8.9 Mil1.5%46ADD +163.7%13F
    Foresite Capital Management VI LLC$6.0 Mil1.3%17New13F
    Vivo Capital, LLC$8.0 Mil0.7%46New13F
    BVF Inc/Il$8.2 Mil0.3%41New13F
    Active ManagerValue% of PortfolioTotal PositionsQoQFiling
    BVF Inc/Il$8.2 Mil0.3%41New13F
    Vivo Capital, LLC$8.0 Mil0.7%46New13F
    Foresite Capital Management VI LLC$6.0 Mil1.3%17New13F
    Prosight Management, LP$8.9 Mil1.5%46ADD +163.7%13F
    Active Manager
    Active ManagerValue% of PortfolioTotal PositionsQoQFiling
    Acorn Capital Advisors, LLC$11.8 Mil3.3%22Hold13F
    Prosight Management, LP$8.9 Mil1.5%46ADD +163.7%13F
    BVF Inc/Il$8.2 Mil0.3%41New13F
    Vivo Capital, LLC$8.0 Mil0.7%46New13F
    Foresite Capital Management VI LLC$6.0 Mil1.3%17New13F
    Core Cache Last Updated: 11/5/2026