Olema Pharmaceuticals (OLMA)
Market Price (7/22/2026): $11.58 | Market Cap: $1.2 BilSector: Health Care | Industry: Biotechnology
Olema Pharmaceuticals (OLMA)
Market Price (7/22/2026): $11.58Market Cap: $1.2 BilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -42% Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more. | Weak multi-year price returns2Y Excs Rtn is -54%, 3Y Excs Rtn is -25% Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14% | Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -202 Mil Stock price has recently run up significantly12M Rtn12 month market price return is 153% Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -20% High stock price volatilityVol 12M is 160% Key risksOLMA key risks include [1] binary Phase 3 results for its lead drug palazestrant, Show more. |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -42% |
| Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -54%, 3Y Excs Rtn is -25% |
| Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 14% |
| Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -202 Mil |
| Stock price has recently run up significantly12M Rtn12 month market price return is 153% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -20% |
| High stock price volatilityVol 12M is 160% |
| Key risksOLMA key risks include [1] binary Phase 3 results for its lead drug palazestrant, Show more. |
Qualitative Assessment
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Olema Pharmaceuticals (OLMA) stock has lost about 20% since 3/31/2026 because of the following key factors:
1. Accelerated Operating Losses Driven by Increased R&D Expenses.
Olema Pharmaceuticals, a clinical-stage company with no product sales, reported a widening net loss in fiscal Q1 2026, reaching $(53.1) million. This represented a deterioration from a net loss of $(30.4) million in fiscal Q1 2025, with the diluted loss per share increasing by 44.4% year-over-year from $(0.36) to $(0.52). The increased loss was primarily due to higher research and development (R&D) spending and headcount to support late-stage clinical trials for palazestrant (OPERA-01 and OPERA-02) and early-stage studies for OP-3136, indicating significant cash burn as the company advances its pipeline.
2. Anticipation of Key Clinical Trial Data Further in Fiscal 2026.
A significant near-term catalyst, the top-line data from the pivotal Phase 3 OPERA-01 trial of palazestrant (OP-1250) as a monotherapy, is not expected until "fall 2026." The period since March 31, 2026 (covering fiscal Q2 2026), did not include this high-impact data readout. While initial clinical results from the Phase 1 study of OP-3136 were presented in May 2026 at ASCO, showing encouraging tolerability and anti-tumor activity across multiple solid tumor types, this early-stage data may not have been sufficient to significantly bolster investor confidence against the backdrop of increased operating losses and the waiting period for the more advanced palazestrant data.
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Olema Pharmaceuticals (OLMA) stock has lost about 20% since 3/31/2026 because of the following key factors:
1. Accelerated Operating Losses Driven by Increased R&D Expenses.
Olema Pharmaceuticals, a clinical-stage company with no product sales, reported a widening net loss in fiscal Q1 2026, reaching $(53.1) million. This represented a deterioration from a net loss of $(30.4) million in fiscal Q1 2025, with the diluted loss per share increasing by 44.4% year-over-year from $(0.36) to $(0.52). The increased loss was primarily due to higher research and development (R&D) spending and headcount to support late-stage clinical trials for palazestrant (OPERA-01 and OPERA-02) and early-stage studies for OP-3136, indicating significant cash burn as the company advances its pipeline.
2. Anticipation of Key Clinical Trial Data Further in Fiscal 2026.
A significant near-term catalyst, the top-line data from the pivotal Phase 3 OPERA-01 trial of palazestrant (OP-1250) as a monotherapy, is not expected until "fall 2026." The period since March 31, 2026 (covering fiscal Q2 2026), did not include this high-impact data readout. While initial clinical results from the Phase 1 study of OP-3136 were presented in May 2026 at ASCO, showing encouraging tolerability and anti-tumor activity across multiple solid tumor types, this early-stage data may not have been sufficient to significantly bolster investor confidence against the backdrop of increased operating losses and the waiting period for the more advanced palazestrant data.
3. Analyst Price Target Adjustments.
Despite a general "Strong Buy" or "Moderate Buy" consensus rating from analysts, some firms adjusted their price targets downwards during or immediately prior to the specified period. For example, Guggenheim lowered its price target from $38 to $35 on May 13, 2026, and Goldman Sachs reduced its target from $38 to $27 on March 18, 2026. These downward revisions in price targets, even while maintaining positive ratings, likely contributed to a re-evaluation of the stock's near-term valuation by investors, putting downward pressure on the share price.
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Stock Movement Drivers
Fundamental Drivers
The -22.3% change in OLMA stock from 3/31/2026 to 7/21/2026 was primarily driven by a -11.1% change in the company's Shares Outstanding (Mil).| (LTM values as of) | 3312026 | 7212026 | Change |
|---|---|---|---|
| Stock Price ($) | 14.91 | 11.59 | -22.3% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 0 | 0 | 0.0% |
| P/S Multiple | ∞ | ∞ | 0.0% |
| Shares Outstanding (Mil) | 91 | 103 | -11.1% |
| Cumulative Contribution | 0.0% |
Market Drivers
3/31/2026 to 7/21/2026| Return | Correlation | |
|---|---|---|
| OLMA | -22.3% | |
| Market (SPY) | 15.1% | 26.5% |
| Sector (XLV) | 9.3% | 15.3% |
Fundamental Drivers
The -53.6% change in OLMA stock from 12/31/2025 to 7/21/2026 was primarily driven by a -16.6% change in the company's Shares Outstanding (Mil).| (LTM values as of) | 12312025 | 7212026 | Change |
|---|---|---|---|
| Stock Price ($) | 25.00 | 11.59 | -53.6% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 0 | 0 | 0.0% |
| P/S Multiple | ∞ | ∞ | 0.0% |
| Shares Outstanding (Mil) | 86 | 103 | -16.6% |
| Cumulative Contribution | 0.0% |
Market Drivers
12/31/2025 to 7/21/2026| Return | Correlation | |
|---|---|---|
| OLMA | -53.6% | |
| Market (SPY) | 10.0% | 24.9% |
| Sector (XLV) | 3.9% | 19.2% |
Fundamental Drivers
The 172.1% change in OLMA stock from 6/30/2025 to 7/21/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).| (LTM values as of) | 6302025 | 7212026 | Change |
|---|---|---|---|
| Stock Price ($) | 4.26 | 11.59 | 172.1% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 0 | 0 | 0.0% |
| P/S Multiple | ∞ | ∞ | 0.0% |
| Shares Outstanding (Mil) | 85 | 103 | -16.9% |
| Cumulative Contribution | 0.0% |
Market Drivers
6/30/2025 to 7/21/2026| Return | Correlation | |
|---|---|---|
| OLMA | 172.1% | |
| Market (SPY) | 22.1% | 1.8% |
| Sector (XLV) | 20.4% | 13.7% |
Fundamental Drivers
The 28.3% change in OLMA stock from 6/30/2023 to 7/21/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).| (LTM values as of) | 6302023 | 7212026 | Change |
|---|---|---|---|
| Stock Price ($) | 9.03 | 11.59 | 28.3% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 0 | 0 | 0.0% |
| P/S Multiple | ∞ | ∞ | 0.0% |
| Shares Outstanding (Mil) | 40 | 103 | -60.7% |
| Cumulative Contribution | 0.0% |
Market Drivers
6/30/2023 to 7/21/2026| Return | Correlation | |
|---|---|---|
| OLMA | 28.3% | |
| Market (SPY) | 74.8% | 11.0% |
| Sector (XLV) | 26.4% | 17.8% |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| OLMA Return | -81% | -74% | 473% | -58% | 329% | -55% | -76% |
| Peers Return | -8% | -31% | -24% | -16% | -9% | -1% | -63% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 9% | 98% |
Monthly Win Rates [3] | |||||||
| OLMA Win Rate | 25% | 33% | 75% | 25% | 58% | 14% | |
| Peers Win Rate | 42% | 48% | 42% | 48% | 50% | 51% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 43% | |
Max Drawdowns [4] | |||||||
| OLMA Max Drawdown | -84% | -78% | -35% | -66% | -54% | -69% | |
| Peers Max Drawdown | -59% | -69% | -66% | -58% | -69% | -37% | |
| S&P 500 Max Drawdown | -5% | -25% | -10% | -8% | -19% | -9% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: ARVN, VERU, ZYME, KPTI, CLDX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 7/21/2026 (YTD)
How Low Can It Go
| Event | OLMA | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -40.7% | -18.8% |
| % Gain to Breakeven | 68.6% | 23.1% |
| Time to Breakeven | 22 days | 79 days |
| 2023 SVB Regional Banking Crisis | ||
| % Loss | -32.8% | -6.7% |
| % Gain to Breakeven | 48.8% | 7.1% |
| Time to Breakeven | 23 days | 31 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -78.4% | -24.5% |
| % Gain to Breakeven | 362.3% | 32.4% |
| Time to Breakeven | 413 days | 427 days |
In The Past
Olema Pharmaceuticals's stock fell -40.7% during the 2025 US Tariff Shock. Such a loss loss requires a 68.6% gain to breakeven.
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| Event | OLMA | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -40.7% | -18.8% |
| % Gain to Breakeven | 68.6% | 23.1% |
| Time to Breakeven | 22 days | 79 days |
| 2023 SVB Regional Banking Crisis | ||
| % Loss | -32.8% | -6.7% |
| % Gain to Breakeven | 48.8% | 7.1% |
| Time to Breakeven | 23 days | 31 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -78.4% | -24.5% |
| % Gain to Breakeven | 362.3% | 32.4% |
| Time to Breakeven | 413 days | 427 days |
In The Past
Olema Pharmaceuticals's stock fell -40.7% during the 2025 US Tariff Shock. Such a loss loss requires a 68.6% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
About Olema Pharmaceuticals (OLMA)
Olema Pharmaceuticals, Inc. (OLMA) is a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing innovative therapies for women's cancers. As a company in the clinical development phase, its core business revolves around advancing potential drug candidates through rigorous research and clinical trials with the goal of bringing new treatments to patients.
The company's primary product candidate is OP-1250, an investigational drug designed to act as an estrogen receptor (ER) antagonist and a selective ER degrader. OP-1250 is currently in Phase 1/2 clinical trials, evaluating its potential as a treatment for recurrent, locally advanced, or metastatic estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer.
Olema Pharmaceuticals serves the pharmaceutical and healthcare market, specifically targeting the oncology sector with a focus on women's cancers. Its eventual customers, upon successful development and regulatory approval, would be medical professionals, such as oncologists and other healthcare providers, who treat patients with advanced ER-positive breast cancer.
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Here are 1-2 brief analogies for Olema Pharmaceuticals:
An early-stage Seagen for women's cancer treatments.
A developing Incyte specializing in women's cancer drugs.
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- OP-1250: A lead drug candidate in Phase 1/2 clinical trials, developed as an estrogen receptor antagonist and selective ER degrader for the treatment of certain types of breast cancer.
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Olema Pharmaceuticals, Inc. (OLMA) is a clinical-stage biopharmaceutical company. As described, its lead product candidate, OP-1250, is currently in Phase 1/2 clinical trials. This means the company is primarily engaged in the discovery and development of therapies and has not yet commercialized any products.
Therefore, Olema Pharmaceuticals does not currently have major customers that purchase its products or services. Its activities are focused on research and development to bring its drug candidates through clinical trials and regulatory approval.
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Dr. Bohen was appointed President and Chief Executive Officer of Olema Pharmaceuticals in September 2020 and led the company's IPO in November 2020. A medical oncologist and biochemist by training, he previously served as Executive Vice President of Global Medicines Development and Chief Medical Officer at AstraZeneca for approximately five years and led early development at Genentech for about 13 years.
Shane Kovacs Former Chief Operating and Financial Officer
Mr. Kovacs departed Olema Pharmaceuticals as Chief Operating and Financial Officer on January 30, 2026, to pursue new opportunities, but will continue in a consulting role with the company through August 1, 2026. He joined Olema in 2020 and contributed to guiding the company's lead product candidate, palazestrant, through late-stage clinical development, building the finance team, and establishing a strong capital position.
David Myles, Ph.D. Chief Discovery and Non-Clinical Development Officer
Naseem Zojwalla, M.D. Chief Medical Officer
Shawnte Mitchell, J.D. Chief Legal Officer and Corporate Secretary
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The key risks to Olema Pharmaceuticals (OLMA) are primarily associated with the inherent uncertainties of clinical-stage biopharmaceutical development, particularly concerning its lead product candidate, palazestrant (OP-1250).
1. Clinical Trial Failure and Regulatory Approval Risk
Olema Pharmaceuticals is a clinical-stage company with no products currently approved for commercial sale, making its value heavily dependent on the successful progression and eventual regulatory approval of its lead drug candidate, palazestrant. The company's future is significantly tied to the outcomes of its clinical trials, including the pivotal Phase 3 OPERA-01 study. A recent example highlighting this risk was the substantial decline in OLMA's stock (falling by -25.75% to -41%) following the disappointing results of a competitor's (Roche's giredestrant) similar drug in a late-stage Phase 3 clinical trial. This event raised concerns among investors about the entire class of selective estrogen receptor degraders (SERDs) that Olema is developing, even though palazestrant is a distinct molecule. Any setbacks in these trials, such as lack of efficacy, safety concerns, or failure to meet primary endpoints, could severely impact the company's prospects and stock price.
2. Competition
Olema operates in a competitive landscape, contending with other developers of oral SERDs and established endocrine therapies for breast cancer. The market share for palazestrant, if approved, will depend on its performance in pivotal trials, subsequent regulatory approvals, and its pricing compared to existing standards of care. The failure of a competitor's drug, as seen with Roche's giredestrant, underscores the intense competition and the potential for negative sentiment to impact the entire drug class, regardless of direct product differences. Olema must differentiate palazestrant in terms of efficacy and safety to succeed against both current treatments and other emerging therapies.
3. Capital Needs and Operating Losses
As a clinical-stage biopharmaceutical company without approved products or product revenue, Olema Pharmaceuticals consistently incurs significant net losses and requires substantial additional capital to fund its operations and ongoing research and development programs. Analysts anticipate widening losses as the company advances its lead drug candidate through late-stage trials. The intensive cash burn associated with drug development means that the company may need to secure additional financing, potentially through selling new shares, which could dilute the value for existing stockholders. Failure to raise necessary capital on favorable terms could force Olema to delay or discontinue critical development programs, directly impacting its future growth and valuation.
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Major pharmaceutical companies are developing advanced oral selective estrogen receptor degrader (SERD) therapies for ER-positive, HER2-negative breast cancer that are significantly further along in clinical development than Olema's lead candidate, OP-1250. For instance, oral SERDs such as Arvinas/Pfizer's vepdegestrant, Eli Lilly's imoventant, and Roche's giredestrant are currently in Phase 3 clinical trials, while OP-1250 is in Phase 1/2. Should these competitors successfully complete their pivotal trials and gain regulatory approval, they could establish a dominant market position for oral SERDs, potentially limiting the future market opportunity and commercial viability for OP-1250.
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- Successful Advancement and Potential Regulatory Milestones for Palazestrant (OP-1250): The most significant driver of future revenue growth for Olema Pharmaceuticals is the successful progression of its lead product candidate, palazestrant (OP-1250), through pivotal Phase 3 clinical trials and towards potential regulatory approval. Top-line data from the Phase 3 OPERA-01 monotherapy study is anticipated in the second half of 2026, which is a critical catalyst for validating the drug's potential. Additionally, the Phase 3 OPERA-02 trial, evaluating palazestrant in combination with ribociclib, is actively enrolling patients. Positive outcomes from these trials and the subsequent submission of a New Drug Application (NDA) to the FDA for potential approval, with preparations for a possible commercial launch set for late 2027, are crucial for future product-based revenue.
- Strategic Partnerships and Collaborations: Olema Pharmaceuticals has demonstrated a strategy of forging significant collaborations to advance its pipeline. The company has a collaboration with Novartis for the Phase 3 OPERA-02 trial. Such strategic partnerships can provide substantial upfront payments, research funding, and milestone payments upon the achievement of specific clinical, regulatory, or commercial goals. These payments are a key source of revenue for clinical-stage biopharmaceutical companies like Olema. There is also mention of a potential collaboration with Pfizer and an ongoing Phase 1b/2 study with atirmociclib.
- Progression of OP-3136 and Pipeline Expansion: Beyond palazestrant, the advancement of other pipeline candidates, such as OP-3136 (a potent lysine acetyltransferase 6 (KAT6) inhibitor), represents another potential driver of future revenue. Initial clinical results for OP-3136 are expected in the second quarter of 2026. Successful development of additional assets can broaden the company's therapeutic portfolio, enhance its attractiveness for new partnerships, and potentially lead to new revenue streams through licensing agreements or future product sales.
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Share Repurchases
No information available regarding share repurchases made or authorized by Olema Pharmaceuticals over the last 3-5 years.
Share Issuance
- In November 2025, Olema Pharmaceuticals closed a public offering of 11,500,000 shares of common stock, including the full exercise of the underwriters' option, resulting in gross proceeds of approximately $218.5 million.
- Olema Pharmaceuticals completed an equity private placement in December 2024, raising approximately $250 million.
- In January 2025, the company entered into agreements to exchange approximately 6,070,000 shares of its common stock for pre-funded warrants with Bain Capital, Paradigm BioCapital, and BVF Partners.
Inbound Investments
- Olema Pharmaceuticals secured a $250 million private placement in December 2024 with new and existing institutional and accredited investors, including Bain Capital Life Sciences and other firms, to fund its clinical endeavors.
- The company forged a significant collaboration with Novartis in December 2024 to advance its pivotal Phase 3 OPERA-02 trial, combining palazestrant with ribociclib.
- In November 2025, Olema Pharmaceuticals announced a new clinical trial agreement with Pfizer to evaluate palazestrant in combination with atirmociclib.
Outbound Investments
No information available regarding outbound investments made by Olema Pharmaceuticals over the last 3-5 years.
Capital Expenditures
- Olema Pharmaceuticals' net loss of $162.5 million in 2025 was primarily driven by $178.7 million in operating expenses, reflecting increased research and development (R&D) and clinical trial spending.
- GAAP R&D expenses increased to $157.7 million for the full year 2025, up from $124.5 million in 2024 and $86.1 million in 2023, mainly due to increased spending on clinical operations and development activities for palazestrant and OP-3136.
- In the second quarter of 2025, GAAP R&D expenses included a one-time milestone payment of $10 million made to Aurigene.
Latest Trefis Analyses
| Title | Date | |
|---|---|---|
| DASHBOARDS | ||
| Olema Pharmaceuticals Earnings Notes | 12/27/2025 |
| Title | |
|---|---|
| ARTICLES |
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 9.93 |
| Mkt Cap | 0.9 |
| Rev LTM | 41 |
| Op Inc LTM | -158 |
| FCF LTM | -113 |
| FCF 3Y Avg | -110 |
| CFO LTM | -112 |
| CFO 3Y Avg | -110 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | -46.0% |
| Rev Chg 3Y Avg | 5.2% |
| Rev Chg Q | -91.4% |
| QoQ Delta Rev Chg LTM | -33.6% |
| Op Inc Chg LTM | -23.6% |
| Op Inc Chg 3Y Avg | -30.8% |
| Op Mgn LTM | -212.0% |
| Op Mgn 3Y Avg | -235.5% |
| QoQ Delta Op Mgn LTM | -145.8% |
| CFO/Rev LTM | -188.5% |
| CFO/Rev 3Y Avg | -193.0% |
| FCF/Rev LTM | -191.4% |
| FCF/Rev 3Y Avg | -196.4% |
Price Behavior
| Market Price | $11.59 | |
| Market Cap ($ Bil) | 1.2 | |
| First Trading Date | 11/19/2020 | |
| Distance from 52W High | -67.7% | |
| 50 Days | 200 Days | |
| DMA Price | $11.75 | $17.39 |
| DMA Trend | up | down |
| Distance from DMA | -1.3% | -33.4% |
| 3M | 1YR | |
| Volatility | 61.7% | 160.3% |
| Downside Capture | 185.84 | -73.03 |
| Upside Capture | -20.80 | 51.74 |
| Correlation (SPY) | 19.9% | 1.5% |
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 0.82 | 0.98 | 1.63 | 1.32 | 0.18 | 0.81 |
| Up Beta | 4.04 | 3.61 | 3.17 | 2.83 | 2.70 | 1.08 |
| Down Beta | 2.79 | 0.65 | -0.02 | 0.58 | -0.61 | 0.09 |
| Up Capture | -105% | -21% | 65% | 4% | 49% | 125% |
| Bmk +ve Days | 11 | 24 | 40 | 67 | 140 | 429 |
| Stock +ve Days | 12 | 20 | 32 | 56 | 118 | 369 |
| Down Capture | -48% | 84% | 186% | 166% | -132% | 105% |
| Bmk -ve Days | 10 | 17 | 23 | 58 | 112 | 321 |
| Stock -ve Days | 9 | 21 | 31 | 69 | 133 | 373 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with OLMA | |
|---|---|---|---|---|
| OLMA | 163.8% | 160.0% | 1.11 | - |
| Sector ETF (XLV) | 23.2% | 15.8% | 1.13 | 13.2% |
| Equity (SPY) | 20.3% | 12.6% | 1.19 | 1.3% |
| Gold (GLD) | 21.6% | 28.1% | 0.69 | 5.8% |
| Commodities (DBC) | 31.4% | 19.1% | 1.30 | -3.3% |
| Real Estate (VNQ) | 15.0% | 14.0% | 0.76 | 8.7% |
| Bitcoin (BTCUSD) | -44.6% | 42.9% | -1.25 | 8.2% |
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Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with OLMA | |
|---|---|---|---|---|
| OLMA | -14.4% | 107.8% | 0.31 | - |
| Sector ETF (XLV) | 6.1% | 15.0% | 0.22 | 21.9% |
| Equity (SPY) | 12.9% | 17.1% | 0.58 | 19.5% |
| Gold (GLD) | 17.3% | 18.4% | 0.76 | 6.2% |
| Commodities (DBC) | 8.9% | 19.5% | 0.35 | -0.8% |
| Real Estate (VNQ) | 2.9% | 18.9% | 0.05 | 20.1% |
| Bitcoin (BTCUSD) | 14.9% | 53.4% | 0.46 | 13.5% |
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Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with OLMA | |
|---|---|---|---|---|
| OLMA | -13.3% | 105.6% | 0.21 | - |
| Sector ETF (XLV) | 9.9% | 16.6% | 0.48 | 20.6% |
| Equity (SPY) | 15.2% | 17.9% | 0.72 | 18.9% |
| Gold (GLD) | 11.2% | 16.1% | 0.57 | 6.8% |
| Commodities (DBC) | 7.2% | 17.9% | 0.32 | -0.9% |
| Real Estate (VNQ) | 5.1% | 20.7% | 0.21 | 19.3% |
| Bitcoin (BTCUSD) | 58.7% | 66.2% | 0.99 | 12.3% |
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Earnings Returns History
Updated 6/15/2026| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 5/12/2026 | -6.0% | -13.2% | -33.9% |
| 3/16/2026 | 12.8% | -4.3% | 10.8% |
| 1/12/2026 | -3.1% | -7.2% | -17.9% |
| 11/10/2025 | 4.2% | 0.6% | 267.4% |
| 8/11/2025 | 16.2% | 26.0% | 70.9% |
| 5/13/2025 | -3.8% | 8.5% | -13.2% |
| 3/18/2025 | -0.7% | 1.2% | 2.9% |
| 11/12/2024 | -0.5% | -24.4% | -41.8% |
| ... | |||
| SUMMARY STATS | |||
| # Positive | 11 | 10 | 9 |
| # Negative | 12 | 13 | 14 |
| Median Positive | 6.8% | 5.5% | 21.1% |
| Median Negative | -6.3% | -10.1% | -19.3% |
| Max Positive | 16.2% | 26.0% | 267.4% |
| Max Negative | -26.7% | -36.7% | -61.8% |
| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 5/12/2026 | -6.0% | -13.2% | -33.9% |
| 3/16/2026 | 12.8% | -4.3% | 10.8% |
| 1/12/2026 | -3.1% | -7.2% | -17.9% |
| 11/10/2025 | 4.2% | 0.6% | 267.4% |
| 8/11/2025 | 16.2% | 26.0% | 70.9% |
| 5/13/2025 | -3.8% | 8.5% | -13.2% |
| 3/18/2025 | -0.7% | 1.2% | 2.9% |
| 11/12/2024 | -0.5% | -24.4% | -41.8% |
| 8/6/2024 | -9.9% | -10.1% | -15.1% |
| 5/8/2024 | -9.3% | -9.2% | 21.0% |
| 3/11/2024 | -6.6% | -14.8% | -15.8% |
| 11/7/2023 | 3.1% | -4.5% | -29.8% |
| 8/8/2023 | 12.1% | 14.3% | 21.1% |
| 5/9/2023 | -8.7% | -12.8% | -9.9% |
| 3/9/2023 | 3.5% | 1.3% | -12.8% |
| 11/8/2022 | -5.1% | 2.2% | -20.8% |
| 8/9/2022 | -26.7% | -23.9% | -21.2% |
| 5/9/2022 | 6.8% | 6.8% | 94.2% |
| 2/28/2022 | 15.0% | -6.4% | -3.0% |
| 11/10/2021 | 1.2% | -5.5% | -61.8% |
| 8/10/2021 | 4.9% | 4.1% | 12.8% |
| 5/11/2021 | 13.0% | 13.0% | 37.1% |
| 3/17/2021 | -10.2% | -36.7% | -27.2% |
| SUMMARY STATS | |||
| # Positive | 11 | 10 | 9 |
| # Negative | 12 | 13 | 14 |
| Median Positive | 6.8% | 5.5% | 21.1% |
| Median Negative | -6.3% | -10.1% | -19.3% |
| Max Positive | 16.2% | 26.0% | 267.4% |
| Max Negative | -26.7% | -36.7% | -61.8% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 03/31/2026 | 05/12/2026 | 10-Q |
| 12/31/2025 | 03/16/2026 | 10-K |
| 09/30/2025 | 11/10/2025 | 10-Q |
| 06/30/2025 | 08/11/2025 | 10-Q |
| 03/31/2025 | 05/13/2025 | 10-Q |
| 12/31/2024 | 03/18/2025 | 10-K |
| 09/30/2024 | 11/12/2024 | 10-Q |
| 06/30/2024 | 08/06/2024 | 10-Q |
| 03/31/2024 | 05/08/2024 | 10-Q |
| 12/31/2023 | 03/11/2024 | 10-K |
| 09/30/2023 | 11/07/2023 | 10-Q |
| 06/30/2023 | 08/08/2023 | 10-Q |
| 03/31/2023 | 05/09/2023 | 10-Q |
| 12/31/2022 | 03/09/2023 | 10-K |
| 09/30/2022 | 11/08/2022 | 10-Q |
| 06/30/2022 | 08/09/2022 | 10-Q |
| Report Date | Filing Date | Filing |
|---|---|---|
| 03/31/2026 | 05/12/2026 | 10-Q |
| 12/31/2025 | 03/16/2026 | 10-K |
| 09/30/2025 | 11/10/2025 | 10-Q |
| 06/30/2025 | 08/11/2025 | 10-Q |
| 03/31/2025 | 05/13/2025 | 10-Q |
| 12/31/2024 | 03/18/2025 | 10-K |
| 09/30/2024 | 11/12/2024 | 10-Q |
| 06/30/2024 | 08/06/2024 | 10-Q |
| 03/31/2024 | 05/08/2024 | 10-Q |
| 12/31/2023 | 03/11/2024 | 10-K |
| 09/30/2023 | 11/07/2023 | 10-Q |
| 06/30/2023 | 08/08/2023 | 10-Q |
| 03/31/2023 | 05/09/2023 | 10-Q |
| 12/31/2022 | 03/09/2023 | 10-K |
| 09/30/2022 | 11/08/2022 | 10-Q |
| 06/30/2022 | 08/09/2022 | 10-Q |
| 03/31/2022 | 05/09/2022 | 10-Q |
| 12/31/2021 | 02/28/2022 | 10-K |
| 09/30/2021 | 11/10/2021 | 10-Q |
| 06/30/2021 | 08/10/2021 | 10-Q |
| 03/31/2021 | 05/11/2021 | 10-Q |
| 12/31/2020 | 03/17/2021 | 10-K |
| 09/30/2020 | 11/19/2020 | 424B4 |
Insider Activity
Updated 6/23/2026| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 24.25 | 24,767 | 600,600 | 5,650 | Form |
| 2 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 24.69 | 233 | Form | ||
| 3 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 23.01 | 15,000 | Form | ||
| 4 | Harmon, Cyrus | Direct | Sell | 1212026 | 26.88 | 10,000 | 268,800 | 19,562,458 | Form | |
| 5 | Harmon, Cyrus | Direct | Sell | 1162026 | 29.12 | 3,489 | 101,600 | 21,483,862 | Form |
| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 24.25 | 24,767 | 600,600 | 5,650 | Form |
| 2 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 24.69 | 233 | Form | ||
| 3 | Mitchell, Shawnte | CHIEF LEGAL OFFICER | Direct | Sell | 3052026 | 23.01 | 15,000 | Form | ||
| 4 | Harmon, Cyrus | Direct | Sell | 1212026 | 26.88 | 10,000 | 268,800 | 19,562,458 | Form | |
| 5 | Harmon, Cyrus | Direct | Sell | 1162026 | 29.12 | 3,489 | 101,600 | 21,483,862 | Form | |
| 6 | Kovacs, Shane William Charles | CH. OPERATING & FINANCIAL OFF. | Direct | Sell | 1152026 | 28.73 | 100,000 | 2,873,000 | 4,014,357 | Form |
| 7 | Kovacs, Shane William Charles | CH. OPERATING & FINANCIAL OFF. | Direct | Sell | 1152026 | 28.01 | 3,822 | 107,054 | 6,714,753 | Form |
| 8 | Myles, David C | CH. DISCOV. & NON-CLIN DEV OFF | Direct | Sell | 1142026 | 28.87 | 50,000 | 1,443,651 | 15,671,151 | Form |
| 9 | Myles, David C | CH. DISCOV. & NON-CLIN DEV OFF | Direct | Sell | 1142026 | 27.60 | 50,000 | 1,380,178 | 14,982,136 | Form |
| 10 | Myles, David C | CH. DISCOV. & NON-CLIN DEV OFF | See Footnote | Sell | 1142026 | 28.34 | 10,000 | 283,400 | 4,104,936 | Form |
| 11 | Harmon, Cyrus | Direct | Sell | 12292025 | 28.53 | 2,881 | 82,195 | 21,148,119 | Form | |
| 12 | Zojwalla, Naseem | Chief Medical Officer | Direct | Sell | 12232025 | 27.66 | 99,509 | 2,752,419 | 124,138 | Form |
| 13 | Zojwalla, Naseem | Chief Medical Officer | Direct | Sell | 12232025 | 28.04 | 100,000 | 2,804,000 | 1,514,076 | Form |
| 14 | Clark, Ian T | Direct | Sell | 12232025 | 29.73 | 264,800 | Form | |||
| 15 | Myles, David C | CH. DISCOV. & NON-CLIN DEV OFF | Direct | Sell | 12232025 | 30.46 | 51,000 | 1,553,544 | 16,811,199 | Form |
| 16 | Zojwalla, Naseem | Chief Medical Officer | Direct | Sell | 12232025 | 28.20 | 70,000 | 1,973,729 | 2,932,313 | Form |
| 17 | Harmon, Cyrus | Direct | Sell | 9182025 | 8.33 | 10,000 | 83,300 | 6,198,686 | Form | |
| 18 | Harmon, Cyrus | See Footnote | Sell | 9182025 | 8.32 | 3,086 | 25,676 | 973,673 | Form | |
| 19 | Harmon, Cyrus | Direct | Sell | 9182025 | 8.04 | 10,000 | 80,400 | 6,063,286 | Form | |
| 20 | Harmon, Cyrus | See Footnote | Sell | 9182025 | 8.08 | 1,914 | 15,465 | 970,521 | Form |
Investor Activity (13F)
Updated Jul 22, 2026Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.
| Active Manager | Value | % of Portfolio | Total Positions | QoQ | Filing |
|---|---|---|---|---|---|
| Defilade Capital Management, L.P. | $22.4 Mil | 3.1% | 31 | ADD +21.9% | 13F |
| Cormorant Asset Management, LP | $58.1 Mil | 2.9% | 46 | ADD +41.8% | 13F |
| BVF Inc/Il | $79.0 Mil | 2.5% | 41 | Hold | 13F |
| Paradigm Biocapital Advisors LP | $119.6 Mil | 2.4% | 35 | ADD +6.3% | 13F |
| Lightspeed Management Company, L.L.C. | $20.2 Mil | 2.0% | 8 | TRIM -29.8% | 13F |
| First Turn Management, LLC | $11.5 Mil | 1.3% | 33 | ADD +24.4% | 13F |
| Vivo Capital, LLC | $10.0 Mil | 0.8% | 46 | Hold | 13F |
| Active Manager | Value | % of Portfolio | Total Positions | QoQ | Filing |
|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | $119.6 Mil | 2.4% | 35 | ADD +6.3% | 13F |
| BVF Inc/Il | $79.0 Mil | 2.5% | 41 | Hold | 13F |
| Cormorant Asset Management, LP | $58.1 Mil | 2.9% | 46 | ADD +41.8% | 13F |
| Defilade Capital Management, L.P. | $22.4 Mil | 3.1% | 31 | ADD +21.9% | 13F |
| Lightspeed Management Company, L.L.C. | $20.2 Mil | 2.0% | 8 | TRIM -29.8% | 13F |
| First Turn Management, LLC | $11.5 Mil | 1.3% | 33 | ADD +24.4% | 13F |
| Vivo Capital, LLC | $10.0 Mil | 0.8% | 46 | Hold | 13F |
Industry Resources
External Quote Links
| Y Finance | Barrons |
| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |
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