Tearsheet

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -25%
Penny stock
Mkt Price is 0.9
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
2  Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -4.6 Mil
3  Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -43%
4  High stock price volatility
Vol 12M is 179%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -25%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
2 Penny stock
Mkt Price is 0.9
3 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -4.6 Mil
5 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -43%
6 High stock price volatility
Vol 12M is 179%

Valuation, Metrics & Events

KAPA Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

1. Continued Net Losses Despite Clinical Progress

Kairos Pharma reported a net loss of -$5.06 million for the trailing 12 months ending September 30, 2025, with no revenue, indicating continued unprofitability for the clinical-stage company. While the company's Q3 2025 earnings per share beat analyst estimates, the overall financial picture of sustained losses can temper investor enthusiasm, especially after initial positive news. 2. Profit-Taking After Initial Stock Surge

Prior to September 2025, Kairos Pharma's stock experienced a significant surge, gaining nearly 79% in the six months leading up to the positive interim efficacy results from its Phase 2 trial of ENV105. This substantial run-up likely led to profit-taking by investors, contributing to a subsequent correction in the stock price. 3. Extended Timeline to Commercialization and Revenue Generation

As a clinical-stage biopharmaceutical company, Kairos Pharma is not yet generating revenue, and the commercialization of its lead drug candidate, ENV105, is still in future development phases. The extended timeline to market and profitability can lead to investor caution and pressure on the stock, particularly after the initial excitement of positive clinical trial data has subsided. 4. Bearish Technical Trading Signals

Technical analysis as of early December 2025 indicated a bearish outlook for Kairos Pharma in the mid-term, with a greater number of sell signals than buy signals. The stock price also declined in four of the last ten trading days leading up to December 4, 2025. 5. Potential for Future Share Dilution

Given the company's ongoing operational costs and lack of revenue, there remains an inherent expectation of future financing needs to fund its clinical trials and development programs. Such financing typically involves the issuance of new shares, which can lead to dilution for existing shareholders and exert downward pressure on the stock price.

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Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
KAPA Return------40%-40%
Peers Return2%-1%6%8%-0%3%18%
S&P 500 Return16%27%-19%24%23%17%112%

Monthly Win Rates [3]
KAPA Win Rate----33%30% 
Peers Win Rate13%8%13%12%10%90% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
KAPA Max Drawdown------70% 
Peers Max Drawdown-2%-5%0%-0%-1%-2% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, AIXC, ALPS, BBOT, EVMN.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/4/2025 (YTD)

How Low Can It Go

KAPA has limited trading history. Below is the Health Care sector ETF (XLV) in its place.

Unique KeyEventXLVS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-16.1%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven19.1%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven599 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-28.8%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven40.4%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven116 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-15.8%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven18.8%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven326 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-40.6%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven68.3%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven1100 days1480 days

Compare to


In The Past

SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.

Preserve Wealth

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Asset Allocation

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About Kairos Pharma (KAPA)

Better Bets than Kairos Pharma (KAPA)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select past ideas related to KAPA. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
10.0%10.0%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.7%-7.7%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.9%6.9%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
11.5%11.5%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
8.9%8.9%-5.1%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
10.0%10.0%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.7%-7.7%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
6.9%6.9%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
11.5%11.5%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
8.9%8.9%-5.1%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Kairos Pharma

Peers to compare with:

Financials

KAPAVRTXAIXCALPSBBOTEVMNMedian
NameKairos P.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Mkt Price0.91457.362.631.1711.5421.937.08
Mkt Cap0.0116.9----58.5
Rev LTM011,7230-0100
Op Inc LTM-5-92-5--93-70-70
FCF LTM-53,337-6--60-64-6
FCF 3Y Avg-22,064-10----2
CFO LTM-53,718-6--60-64-6
CFO 3Y Avg-22,419-10----2

Growth & Margins

KAPAVRTXAIXCALPSBBOTEVMNMedian
NameKairos P.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Rev Chg LTM-10.3%----10.3%
Rev Chg 3Y Avg-10.5%----10.5%
Rev Chg Q-11.0%----11.0%
QoQ Delta Rev Chg LTM-2.7%----2.7%
Op Mgn LTM--0.8%----700.7%-350.7%
Op Mgn 3Y Avg-26.2%----26.2%
QoQ Delta Op Mgn LTM-1.0%----1.0%
CFO/Rev LTM-31.7%----635.6%-302.0%
CFO/Rev 3Y Avg-23.1%----23.1%
FCF/Rev LTM-28.5%----636.5%-304.0%
FCF/Rev 3Y Avg-19.8%----19.8%

Valuation

KAPAVRTXAIXCALPSBBOTEVMNMedian
NameKairos P.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
Mkt Cap0.0116.9----58.5
P/S-8.5----8.5
P/EBIT-2.722.4----9.9
P/E-2.627.2----12.3
P/CFO-2.326.9----12.3
Total Yield-38.6%3.7%-----17.5%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-2.3%----2.3%
D/E0.00.0----0.0
Net D/E-0.2-0.0-----0.1

Returns

KAPAVRTXAIXCALPSBBOTEVMNMedian
NameKairos P.Vertex P.AIxCryptoALPS BridgeBi.Evommune  
1M Rtn4.8%8.5%-23.2%-4.6%-6.6%
3M Rtn-41.3%15.2%--14.5%-14.5%
6M Rtn81.0%3.1%----42.0%
12M Rtn-39.4%-1.4%-----20.4%
3Y Rtn-44.0%----44.0%
1M Excs Rtn3.6%7.2%-22.0%-5.9%-5.4%
3M Excs Rtn-52.9%9.7%--10.8%-9.7%
6M Excs Rtn65.5%-12.4%----26.5%
12M Excs Rtn-54.0%-15.2%-----34.6%
3Y Excs Rtn--28.7%-----28.7%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity125,497
Short Interest: % Change Since 10312025-47.5%
Average Daily Volume285,701
Days-to-Cover Short Interest1
Basic Shares Quantity17,213,017
Short % of Basic Shares0.7%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025812202510-Q 6/30/2025
3312025514202510-Q 3/31/2025
12312024415202510-K 12/31/2024
93020241114202410-Q 9/30/2024
33120245132024S-1/A 3/31/2024
123120239172024424B4 12/31/2023
63020239292023S-1 6/30/2023
33120239182023DRS/A 3/31/2023
123120222142024S-1/A 12/31/2022
123120213292023DRS 12/31/2021