Kairos Pharma (KAPA)
Market Price (12/24/2025): $0.752 | Market Cap: $15.2 MilSector: Health Care | Industry: Biotechnology
Kairos Pharma (KAPA)
Market Price (12/24/2025): $0.752Market Cap: $15.2 MilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37% | Penny stockMkt Price is 0.8 |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more. | Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -5.6 Mil | |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -38% | |
| High stock price volatilityVol 12M is 178% | |
| Key risksKAPA key risks include [1] its heavy dependence on the successful outcome of clinical trials for its lead candidate, Show more. |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37% |
| Megatrend and thematic driversMegatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more. |
| Penny stockMkt Price is 0.8 |
| Very low revenueRev LTMTotal Revenue or Sales, Last Twelve Months is 0 |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -5.6 Mil |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -38% |
| High stock price volatilityVol 12M is 178% |
| Key risksKAPA key risks include [1] its heavy dependence on the successful outcome of clinical trials for its lead candidate, Show more. |
Why The Stock Moved
Qualitative Assessment
AI Analysis | Feedback
Here are key points highlighting why Kairos Pharma (KAPA) stock moved by -44.3% from approximately August 31, 2025, to December 24, 2025: 1. Continued Financial Losses and No Revenue. Kairos Pharma reported a net loss of $1.4 million for the third quarter ended September 30, 2025, with no revenue. The company's operating expenses increased as development advanced, raising concerns about ongoing profitability and cash burn.2. Bearish Market Sentiment and Technical Signals. Despite some positive analyst ratings, several market analyses and technical indicators, particularly from algorithmic platforms, signaled a bearish outlook for KAPA. As of December 17, 2025, Wallet Investor indicated a "Strong Sell" and predicted a further drop in the stock price, while Intellectia AI also issued a "Strong Sell" recommendation based on negative technical signals and a falling trend.
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Stock Movement Drivers
Fundamental Drivers
The -34.6% change in KAPA stock from 9/23/2025 to 12/23/2025 was primarily driven by a -17.4% change in the company's Shares Outstanding (Mil).| 9232025 | 12232025 | Change | |
|---|---|---|---|
| Stock Price ($) | 1.15 | 0.75 | -34.61% |
| Change Contribution By | LTM | LTM | |
| Total Revenues ($ Mil) | 0.00 | 0.00 | � |
| P/S Multiple | ∞ | ∞ | � |
| Shares Outstanding (Mil) | 17.21 | 20.21 | -17.39% |
| Cumulative Contribution | � |
Market Drivers
9/23/2025 to 12/23/2025| Return | Correlation | |
|---|---|---|
| KAPA | -34.6% | |
| Market (SPY) | 3.7% | 53.2% |
| Sector (XLV) | 13.2% | 6.6% |
Fundamental Drivers
The 15.9% change in KAPA stock from 6/24/2025 to 12/23/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).| 6242025 | 12232025 | Change | |
|---|---|---|---|
| Stock Price ($) | 0.65 | 0.75 | 15.87% |
| Change Contribution By | LTM | LTM | |
| Total Revenues ($ Mil) | 0.00 | 0.00 | � |
| P/S Multiple | ∞ | ∞ | � |
| Shares Outstanding (Mil) | 15.88 | 20.21 | -27.28% |
| Cumulative Contribution | � |
Market Drivers
6/24/2025 to 12/23/2025| Return | Correlation | |
|---|---|---|
| KAPA | 15.9% | |
| Market (SPY) | 13.7% | 14.5% |
| Sector (XLV) | 16.4% | -7.3% |
Fundamental Drivers
The -56.2% change in KAPA stock from 12/23/2024 to 12/23/2025 was primarily driven by a -85.2% change in the company's Shares Outstanding (Mil).| 12232024 | 12232025 | Change | |
|---|---|---|---|
| Stock Price ($) | 1.72 | 0.75 | -56.15% |
| Change Contribution By | LTM | LTM | |
| Total Revenues ($ Mil) | 0.00 | 0.00 | � |
| P/S Multiple | ∞ | ∞ | � |
| Shares Outstanding (Mil) | 10.91 | 20.21 | -85.20% |
| Cumulative Contribution | � |
Market Drivers
12/23/2024 to 12/23/2025| Return | Correlation | |
|---|---|---|
| KAPA | -56.2% | |
| Market (SPY) | 16.7% | 5.2% |
| Sector (XLV) | 13.2% | 2.7% |
Fundamental Drivers
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Market Drivers
12/24/2023 to 12/23/2025| Return | Correlation | |
|---|---|---|
| KAPA | ||
| Market (SPY) | 48.4% | 5.8% |
| Sector (XLV) | 18.2% | 2.9% |
Price Returns Compared
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| KAPA Return | � | � | � | � | � | -47% | � |
| Peers Return | 40% | 16% | -1% | 10% | 1% | 27% | 128% |
| S&P 500 Return | 16% | 27% | -19% | 24% | 23% | 17% | 114% |
Monthly Win Rates [3] | |||||||
| KAPA Win Rate | � | � | � | � | 33% | 25% | |
| Peers Win Rate | 50% | 52% | 55% | 48% | 55% | 57% | |
| S&P 500 Win Rate | 58% | 75% | 42% | 67% | 75% | 73% | |
Max Drawdowns [4] | |||||||
| KAPA Max Drawdown | � | � | � | � | � | -70% | |
| Peers Max Drawdown | -19% | -13% | -18% | -18% | -18% | -22% | |
| S&P 500 Max Drawdown | -31% | -1% | -25% | -1% | -2% | -15% | |
[1] Cumulative total returns since the beginning of 2020
[2] Peers: EXEL, RCUS, REGN, AMGN, BMY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/23/2025 (YTD)
How Low Can It Go
KAPA has limited trading history. Below is the Health Care sector ETF (XLV) in its place.
| Event | XLV | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -16.1% | -25.4% |
| % Gain to Breakeven | 19.1% | 34.1% |
| Time to Breakeven | 599 days | 464 days |
| 2020 Covid Pandemic | ||
| % Loss | -28.8% | -33.9% |
| % Gain to Breakeven | 40.4% | 51.3% |
| Time to Breakeven | 116 days | 148 days |
| 2018 Correction | ||
| % Loss | -15.8% | -19.8% |
| % Gain to Breakeven | 18.8% | 24.7% |
| Time to Breakeven | 326 days | 120 days |
| 2008 Global Financial Crisis | ||
| % Loss | -40.6% | -56.8% |
| % Gain to Breakeven | 68.3% | 131.3% |
| Time to Breakeven | 1,100 days | 1,480 days |
Compare to
In The Past
SPDR Select Sector Fund's stock fell -16.1% during the 2022 Inflation Shock from a high on 4/8/2022. A -16.1% loss requires a 19.1% gain to breakeven.
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AI Analysis | Feedback
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AI Analysis | Feedback
Kairos Pharma (symbol: KAPA) is a fictional company often used in case studies or educational materials and therefore does not have actual major products or services.AI Analysis | Feedback
As a public pharmaceutical company, Kairos Pharma (KAPA) would primarily sell its products to other companies rather than directly to individual consumers. The major customers for a pharmaceutical manufacturer are typically the large pharmaceutical wholesale distributors, which then supply drugs to pharmacies, hospitals, and other healthcare providers.
Based on the standard business model for a pharmaceutical company operating in major markets, Kairos Pharma's major customers would include:
- McKesson Corporation (MCK)
- AmerisourceBergen Corporation (ABC)
- Cardinal Health, Inc. (CAH)
These three companies are the largest pharmaceutical distributors in the United States and typically account for a significant portion of a pharmaceutical manufacturer's sales revenue, acting as the crucial intermediary in the drug supply chain.
AI Analysis | Feedback
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AI Analysis | Feedback
John S. Yu, Chief Executive Officer & Chairman
Dr. John S. Yu founded Kairos Pharma on June 17, 2013. He is an accomplished neurosurgeon and immunotherapy expert, holding a BAS from Stanford, and an MD from Harvard Medical School and MIT. Dr. Yu also serves as a Professor of Neurosurgery and Director of Surgical Neuro-Oncology at Cedars-Sinai Medical Center. He has developed numerous investigational drugs with the FDA (8 new drugs mentioned) and led multiple clinical trials. Prior to Kairos Pharma, he was the CEO and Chairman of AcTcell, and a Director of Enviro Therapeutics. His career has focused on groundbreaking research in cancer therapeutics, and he holds numerous patents for immunotherapies and nanotechnologies from his NIH-funded laboratory.
Doug Samuelson, Chief Financial Officer
Doug Samuelson brings over 25 years of experience in finance, having served as CFO for various biopharma companies. He is a CPA in the State of California. His previous roles include CFO of Wellness Center USA, CFO of AdvaVet, Inc., CFO of Solis Tek, Inc., and Director of Accounting of Second Sight Medical Products, Inc. His expertise encompasses financial management and regulatory compliance.
Neil Bhowmick, Chief Scientific Officer & President, Enviro Therapeutics
Dr. Neil Bhowmick possesses over 20 years of extensive biochemistry expertise. He has filed and prosecuted patents for therapeutics and devices, authored 110 peer-reviewed publications, and led foundational and preclinical cancer research. He holds 6 patents for biomarker detection platforms and stromal targeted therapeutics, including ENV105 and ENV205. Dr. Bhowmick's background includes a fellowship at Vanderbilt University Medical Center and serving as Research Director at Oppenheimer Urologic Reference Laboratory (OURLab). He has also been a consultant at Xencor Inc. and Tracon Pharma.
Ramchandran Murali, VP, Research and Development
Dr. Ramchandran Murali is an immunologist and molecular engineer recognized for his work in developing pharmacological agents to counter immune suppression in cancer. His extensive research background is instrumental in advancing Kairos Pharma's innovative drug pipeline. He is also a Professor of Biomedical Sciences and Research in Immunology at Penn/Cedars-Sinai Medical Center, and a leading expert in X-ray crystallography, biophysical, biochemical, and immunology fields, having made significant advances in molecular engineering and cell surface receptors. He has developed numerous technologies that reverse key mechanisms of immune suppression of cancer.
AI Analysis | Feedback
Here are the key risks to Kairos Pharma's business:- Clinical Trial and Drug Development Risk: As a clinical-stage biopharmaceutical company, Kairos Pharma's success is heavily reliant on the successful outcome of its ongoing clinical trials for its lead candidate, ENV-105. ENV-105 is currently in Phase 2 clinical trials for prostate cancer and Phase 1 trials for lung cancer. There is no guarantee that the data from these trials will be positive or that the drug will effectively overcome drug resistance as intended. Failure to achieve positive results in these trials, or any future trials, could significantly impact the company's viability and future prospects.
- Financial Position and Need for Future Funding: Kairos Pharma is currently unprofitable, with losses increasing over the past five years. Developing new pharmaceutical products through clinical trials is a capital-intensive process. While the company has a cash balance, it may need to raise additional funds to continue its research and development efforts, especially if clinical trials are extended or further studies become necessary. The ability to secure sufficient future funding is critical and is often contingent on positive clinical trial results and favorable market conditions.
- Regulatory Approval Risk: Even if clinical trials for ENV-105 yield positive results, Kairos Pharma faces significant regulatory hurdles. The company must obtain extensive regulatory approvals from bodies such as the U.S. Food and Drug Administration (FDA) before it can commercialize its drug candidates. The regulatory approval process is complex, lengthy, and subject to unpredictable changes, and there is no assurance that ENV-105 will ultimately receive the necessary approvals.
AI Analysis | Feedback
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AI Analysis | Feedback
Kairos Pharma (KAPA) is a clinical-stage biopharmaceutical company focusing on oncology therapeutics. The addressable markets for their main product candidates are as follows:
- ENV105 (Castrate-Resistant Prostate Cancer): The global castrate-resistant prostate cancer (CRPC) market was estimated at approximately USD 12.95 billion in 2024 and is projected to reach about USD 21.44 billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 8.7% from 2025 to 2030. The metastatic CRPC therapeutics market specifically was valued at USD 16.46 billion in 2024 and is projected to grow to USD 87.19 billion by 2032 with a CAGR of 22.5% during the forecast period.
- ENV105 (Lung Cancer): The global lung cancer therapeutics market size was approximately USD 35.37 billion in 2025 and is forecasted to reach around USD 71.30 billion by 2034, exhibiting a CAGR of 8.10% from 2025 to 2034. Another estimate places the global lung cancer market at USD 38.4 billion in 2025, growing to USD 95.1 billion in 2034 with a CAGR of 10.6%.
- KROS201 (Glioblastoma): The global glioblastoma treatment market was valued at USD 3.05 billion in 2024 and is expected to reach USD 6.22 billion by 2032, at a CAGR of 9.30% during the forecast period. Other projections estimate the global glioblastoma multiforme treatment market to grow from USD 3.72 billion in 2024 to USD 7.87 billion by 2033 with a CAGR of 8.68%.
- KROS401 (Triple Negative Breast Cancer): The global triple negative breast cancer (TNBC) market was valued at USD 1.06 billion in 2024 and is expected to reach USD 1.63 billion by 2032, growing at a CAGR of 5.50% from 2025 to 2032. Another report indicates the global TNBC market size to be USD 1.15 billion in 2025, projected to reach USD 1.41 billion by 2029 with a CAGR of 5.1%.
- KROS101, KROS102, KROS301: Specific addressable market sizes for these individual product candidates beyond the general oncology or immunotherapy market are not available. However, the broader global cancer immunotherapy market was valued at USD 226.38 billion in 2024 and is projected to reach USD 443.17 billion by 2030, growing at a CAGR of 11.90%. The global immunotherapy drugs market, which encompasses these types of therapies, was estimated at USD 257.6 billion in 2024 and is projected to reach USD 486.36 billion by 2030, growing at a CAGR of 11.2%.
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Expected Drivers of Future Revenue Growth for Kairos Pharma (KAPA)
Over the next 2-3 years, Kairos Pharma's potential for revenue growth is primarily linked to the successful advancement and commercialization of its clinical-stage pipeline. The key expected drivers include:
- Advancement and Commercialization of ENV105: Kairos Pharma's lead therapeutic candidate, ENV105, an antibody targeting CD105, is currently undergoing Phase 2 clinical trials for advanced metastatic prostate cancer and Phase 1 trials for lung cancer. The company has reported positive interim safety and efficacy results from the Phase 2 prostate cancer trial. Successful progression through clinical development, regulatory approval, and subsequent market launch of ENV105 would be a significant driver of future product revenue.
- Development and Launch of KROS101: The company has presented promising new data on KROS101, an investigational small molecule GITR ligand agonist, as a potential cancer immunotherapy. If KROS101 successfully navigates clinical trials and gains regulatory approval, its commercialization would introduce a new product and revenue stream for Kairos Pharma.
- Expansion into New Cancer Indications: Kairos Pharma's strategy involves leveraging its lead candidate, ENV105, to address multiple cancer types by reversing drug resistance and restoring the effectiveness of standard therapies. Successful clinical trials and subsequent approvals for additional cancer indications beyond prostate and lung cancer would expand the addressable market and contribute to revenue growth.
- Strategic Partnerships and Collaborations: Recent partnerships are anticipated to enhance Kairos Pharma's innovation in pharmaceutical products and bolster its research and development capabilities. These collaborations could generate revenue through various mechanisms, such as upfront payments, milestone payments tied to development progress, and royalty streams from licensed assets.
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Share Issuance
- On September 16, 2024, Kairos Pharma completed its Initial Public Offering (IPO), issuing 1.55 million common shares at an offering price of $4.00 per share, raising gross proceeds of $6.2 million.
- In January 2025, the company raised an additional $3.5 million through a Private Investment in Public Equity (PIPE) transaction by selling 2.5 million common units at $1.40 each, along with warrants.
- The total number of shares outstanding for Kairos Pharma increased by 35.56% in one year.
Inbound Investments
- The company's Phase 2 clinical trial for ENV105 in prostate cancer is partially funded by a $3.2 million NIH grant.
- Kairos Pharma raised $3.5 million in January 2025 via a Private Investment in Public Equity (PIPE) transaction from accredited investors.
- In November 2025, Kairos Pharma received a Department of Defense grant to support the study of its lead candidate ENV105 for preventing drug resistance in lung cancer, and another grant for research of ENV205 to treat chemotherapy drug resistance and cachexia.
Capital Expenditures
- Proceeds from the IPO and subsequent financings are primarily allocated to advancing clinical trials, including Phase 1 and 2 trials for its lead candidate ENV-105 in lung and prostate cancer.
- The company's operational expenses, largely driven by research and development as a clinical-stage biopharmaceutical company, are projected to be $3.7 million for 2025 and $7.2 million for 2026.
- Kairos Pharma reported a quarterly burn rate of approximately $0.6 million.
Latest Trefis Analyses
| Title | Topic | |
|---|---|---|
| DASHBOARDS | ||
| Day 8 of Gains Streak for Kairos Pharma Stock with 67% Return (vs. 30% YTD) [9/9/2025] | Notification |
| Title | |
|---|---|
| ARTICLES |
Trade Ideas
Select ideas related to KAPA. For more, see Trefis Trade Ideas.
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Research & Analysis
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Peer Comparisons for Kairos Pharma
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 50.45 |
| Mkt Cap | 46.9 |
| Rev LTM | 8,268 |
| Op Inc LTM | 2,314 |
| FCF LTM | 2,313 |
| FCF 3Y Avg | 2,140 |
| CFO LTM | 2,931 |
| CFO 3Y Avg | 2,700 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 2.9% |
| Rev Chg 3Y Avg | 11.2% |
| Rev Chg Q | 2.8% |
| QoQ Delta Rev Chg LTM | 0.7% |
| Op Mgn LTM | 24.1% |
| Op Mgn 3Y Avg | 22.5% |
| QoQ Delta Op Mgn LTM | 0.6% |
| CFO/Rev LTM | 34.6% |
| CFO/Rev 3Y Avg | 31.7% |
| FCF/Rev LTM | 31.9% |
| FCF/Rev 3Y Avg | 28.2% |
Price Behavior
| Market Price | $0.75 | |
| Market Cap ($ Bil) | 0.0 | |
| First Trading Date | 09/16/2024 | |
| Distance from 52W High | -64.7% | |
| 50 Days | 200 Days | |
| DMA Price | $0.91 | $1.32 |
| DMA Trend | down | down |
| Distance from DMA | -17.1% | -43.2% |
| 3M | 1YR | |
| Volatility | 91.1% | 179.0% |
| Downside Capture | 369.67 | 34.33 |
| Upside Capture | 106.01 | -52.25 |
| Correlation (SPY) | 54.2% | 5.5% |
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 4.78 | 3.99 | 3.08 | 1.48 | 0.40 | 1.12 |
| Up Beta | 7.56 | 6.45 | 6.19 | 3.37 | 0.13 | -0.68 |
| Down Beta | 7.09 | 6.27 | 6.56 | 5.72 | 1.44 | -0.89 |
| Up Capture | 104% | 90% | -68% | -7% | -24% | -3% |
| Bmk +ve Days | 13 | 26 | 39 | 74 | 142 | 427 |
| Stock +ve Days | 7 | 17 | 28 | 57 | 103 | 123 |
| Down Capture | 464% | 311% | 179% | -180% | 13% | 46% |
| Bmk -ve Days | 7 | 16 | 24 | 52 | 107 | 323 |
| Stock -ve Days | 13 | 23 | 32 | 64 | 139 | 170 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
nullBased On 5-Year Data
nullBased On 10-Year Data
nullSEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 9302025 | 11142025 | 10-Q 9/30/2025 |
| 6302025 | 8122025 | 10-Q 6/30/2025 |
| 3312025 | 5142025 | 10-Q 3/31/2025 |
| 12312024 | 4152025 | 10-K 12/31/2024 |
| 9302024 | 11142024 | 10-Q 9/30/2024 |
| 3312024 | 5132024 | S-1/A 3/31/2024 |
| 12312023 | 9172024 | 424B4 12/31/2023 |
| 6302023 | 9292023 | S-1 6/30/2023 |
| 3312023 | 9182023 | DRS/A 3/31/2023 |
| 12312022 | 2142024 | S-1/A 12/31/2022 |
| 12312021 | 3292023 | DRS 12/31/2021 |
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