Arcus Biosciences (RCUS)


Market Price (8/8/2026): $28.62 | Market Cap: $3.6 BilSector: Health Care | Industry: Biotechnology

Arcus Biosciences (RCUS)


Market Price (8/8/2026): $28.62
Market Cap: $3.6 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -16%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.

Weak multi-year price returns
3Y Excs Rtn is -22%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.92

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -486 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -415%

Stock price has recently run up significantly
12M Rtn12 month market price return is 208%

Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -55%, Rev Chg QQuarterly Revenue Change % is -74%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 54%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -405%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -406%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 169%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -17%

Key risks
RCUS key risks include [1] the recent discontinuation of its Phase 3 STAR-221 study due to futility and [2] a significant bankruptcy risk as indicated by its low Altman Z-Score.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -16%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
2 Weak multi-year price returns
3Y Excs Rtn is -22%
3 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 12.92
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -486 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -415%
5 Stock price has recently run up significantly
12M Rtn12 month market price return is 208%
6 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -55%, Rev Chg QQuarterly Revenue Change % is -74%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 54%
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -405%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -406%
9 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 169%
10 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -17%
11 Key risks
RCUS key risks include [1] the recent discontinuation of its Phase 3 STAR-221 study due to futility and [2] a significant bankruptcy risk as indicated by its low Altman Z-Score.

RCUS in ETFs

Weight = RCUS's share of each fund

ITOT0.00%
IWM0.08%
IJR0.14%
VB0.02%
XBI0.72%
IBB0.19%
IJT0.18%
SLYG0.17%
+14 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 8/5/2026

Arcus Biosciences (RCUS) stock has gained about 10% since 4/30/2026 because of the following key factors:

1. Strong Advancement and Expansion of the Casdatifan Program.

Arcus Biosciences' lead investigational drug, casdatifan, a HIF-2α inhibitor for clear cell renal cell carcinoma (ccRCC), has demonstrated significant progress and strategic expansion during the period. Management has outlined a vision for casdatifan as a potential "backbone therapy" with a market opportunity of $5 billion to $10 billion. The company has initiated multiple new clinical trial collaborations, including partnerships with Bristol Myers Squibb, Summit Therapeutics, and AVEO Oncology, to evaluate casdatifan in various combinations and settings. Key milestones include the ongoing Phase 3 PEAK-1 trial for second-line ccRCC, which is on track to complete enrollment by the end of fiscal year 2026, and the planned initiation of the first-line registrational Phase 3 PEAK-20 trial by year-end 2026. Furthermore, new research published in Nature highlighted that casdatifan produced deep and sustained suppression of serum erythropoietin, which correlated with higher response rates and longer progression-free survival in ccRCC patients.

2. Better-than-Expected Fiscal Q2 2026 Earnings.

Arcus Biosciences reported stronger-than-anticipated financial results for its fiscal Q2 2026, which ended June 30, 2026. The company posted a diluted earnings per share (EPS) of -$0.72, exceeding analyst estimates of -$0.90 by $0.18. Additionally, revenue for the quarter reached $41 million, significantly surpassing the consensus estimate of $22.2 million. While year-over-year revenue declined due to a substantial one-time licensing catch-up in the prior year, the beat against expectations provided a positive signal to investors regarding the company's financial performance.

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Updated on 8/5/2026

Arcus Biosciences (RCUS) stock has gained about 10% since 4/30/2026 because of the following key factors:

1. Strong Advancement and Expansion of the Casdatifan Program.

Arcus Biosciences' lead investigational drug, casdatifan, a HIF-2α inhibitor for clear cell renal cell carcinoma (ccRCC), has demonstrated significant progress and strategic expansion during the period. Management has outlined a vision for casdatifan as a potential "backbone therapy" with a market opportunity of $5 billion to $10 billion. The company has initiated multiple new clinical trial collaborations, including partnerships with Bristol Myers Squibb, Summit Therapeutics, and AVEO Oncology, to evaluate casdatifan in various combinations and settings. Key milestones include the ongoing Phase 3 PEAK-1 trial for second-line ccRCC, which is on track to complete enrollment by the end of fiscal year 2026, and the planned initiation of the first-line registrational Phase 3 PEAK-20 trial by year-end 2026. Furthermore, new research published in Nature highlighted that casdatifan produced deep and sustained suppression of serum erythropoietin, which correlated with higher response rates and longer progression-free survival in ccRCC patients.

2. Better-than-Expected Fiscal Q2 2026 Earnings.

Arcus Biosciences reported stronger-than-anticipated financial results for its fiscal Q2 2026, which ended June 30, 2026. The company posted a diluted earnings per share (EPS) of -$0.72, exceeding analyst estimates of -$0.90 by $0.18. Additionally, revenue for the quarter reached $41 million, significantly surpassing the consensus estimate of $22.2 million. While year-over-year revenue declined due to a substantial one-time licensing catch-up in the prior year, the beat against expectations provided a positive signal to investors regarding the company's financial performance.

3. Favorable Analyst Sentiment and Increased Price Targets.

Wall Street analysts maintained a predominantly positive outlook on Arcus Biosciences, with a consensus "Strong Buy" or "Buy" rating for RCUS shares during the period. The average price target ranged from approximately $36.40 to $38.63, suggesting a notable upside potential (e.g., 29% upside from the $28.80 share price as of August 5, 2026). Notably, H.C. Wainwright raised its price target for RCUS from $32 to $45 in July 2026, explicitly citing the potential for casdatifan to be the first HIF-2α inhibitor marketed in first-line ccRCC and its competitive profile against rival treatments.

4. Robust Cash Runway.

Arcus Biosciences reported a solid financial position with cash, cash equivalents, and marketable securities totaling $775 million as of June 30, 2026. The company's management projects ending fiscal year 2026 with approximately $600 million in cash and expects these resources to be sufficient to fund planned operations until at least the second half of 2028. This extended cash runway alleviates concerns about near-term financing needs and provides confidence in the company's ability to advance its clinical pipeline.

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Stock Movement Drivers

Fundamental Drivers

The 12.2% change in RCUS stock from 4/30/2026 to 8/7/2026 was primarily driven by a 152.1% change in the company's P/S Multiple.
(LTM values as of)43020268072026Change
Stock Price ($)25.5028.6212.2%
Change Contribution By: 
Total Revenues ($ Mil)247117-52.6%
P/S Multiple12.230.8152.1%
Shares Outstanding (Mil)118126-6.0%
Cumulative Contribution12.2%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2026 to 8/7/2026
ReturnCorrelation
RCUS12.2% 
Market (SPY)7.6%35.1%
Sector (XLV)13.5%4.1%

Fundamental Drivers

The 36.0% change in RCUS stock from 1/31/2026 to 8/7/2026 was primarily driven by a 230.4% change in the company's P/S Multiple.
(LTM values as of)13120268072026Change
Stock Price ($)21.0428.6236.0%
Change Contribution By: 
Total Revenues ($ Mil)240117-51.2%
P/S Multiple9.330.8230.4%
Shares Outstanding (Mil)106126-15.5%
Cumulative Contribution36.0%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 8/7/2026
ReturnCorrelation
RCUS36.0% 
Market (SPY)12.1%42.2%
Sector (XLV)7.5%16.3%

Fundamental Drivers

The 213.5% change in RCUS stock from 7/31/2025 to 8/7/2026 was primarily driven by a 384.1% change in the company's P/S Multiple.
(LTM values as of)73120258072026Change
Stock Price ($)9.1328.62213.5%
Change Contribution By: 
Total Revenues ($ Mil)141117-17.0%
P/S Multiple6.430.8384.1%
Shares Outstanding (Mil)98126-22.0%
Cumulative Contribution213.5%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2025 to 8/7/2026
ReturnCorrelation
RCUS213.5% 
Market (SPY)23.4%35.8%
Sector (XLV)28.7%16.4%

Fundamental Drivers

The 43.8% change in RCUS stock from 7/31/2023 to 8/7/2026 was primarily driven by a 152.7% change in the company's P/S Multiple.
(LTM values as of)73120238072026Change
Stock Price ($)19.9028.6243.8%
Change Contribution By: 
Total Revenues ($ Mil)119117-1.7%
P/S Multiple12.230.8152.7%
Shares Outstanding (Mil)73126-42.1%
Cumulative Contribution43.8%

LTM = Last Twelve Months as of date shown

Market Drivers

7/31/2023 to 8/7/2026
ReturnCorrelation
RCUS43.8% 
Market (SPY)74.9%36.8%
Sector (XLV)29.3%30.4%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
RCUS Return56%-49%-8%-22%60%19%9%
Peers Return-7%32%-21%-50%56%2547480%1909342%
S&P 500 Return27%-19%24%23%16%13%105%

Monthly Win Rates [3]
RCUS Win Rate58%42%42%50%58%50% 
Peers Win Rate42%67%46%34%46%31% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
RCUS Max Drawdown-45%-59%-43%-32%-55%-23% 
Peers Max Drawdown-27%-19%-12%-62%-64%-58% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: VRTX, APMD, ATTO, BLSM, BRVE.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 8/7/2026 (YTD)

How Low Can It Go

EventRCUSS&P 500
2025 US Tariff Shock
  % Loss-38.1%-18.8%
  % Gain to Breakeven61.6%23.1%
  Time to Breakeven152 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-30.3%-9.5%
  % Gain to Breakeven43.6%10.5%
  Time to Breakeven45 days24 days
2023 SVB Regional Banking Crisis
  % Loss-19.9%-6.7%
  % Gain to Breakeven24.8%7.1%
  Time to Breakeven30 days31 days
2020 COVID-19 Crash
  % Loss-36.5%-33.7%
  % Gain to Breakeven57.4%50.9%
  Time to Breakeven21 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-37.2%-19.2%
  % Gain to Breakeven59.2%23.8%
  Time to Breakeven411 days105 days

Compare to TGTX, RYTM, PCRX, OPK, ARVN

In The Past

Arcus Biosciences's stock fell -38.1% during the 2025 US Tariff Shock. Such a loss loss requires a 61.6% gain to breakeven.

Preserve Wealth

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Asset Allocation

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EventRCUSS&P 500
2025 US Tariff Shock
  % Loss-38.1%-18.8%
  % Gain to Breakeven61.6%23.1%
  Time to Breakeven152 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-30.3%-9.5%
  % Gain to Breakeven43.6%10.5%
  Time to Breakeven45 days24 days
2020 COVID-19 Crash
  % Loss-36.5%-33.7%
  % Gain to Breakeven57.4%50.9%
  Time to Breakeven21 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-37.2%-19.2%
  % Gain to Breakeven59.2%23.8%
  Time to Breakeven411 days105 days

Compare to TGTX, RYTM, PCRX, OPK, ARVN

In The Past

Arcus Biosciences's stock fell -38.1% during the 2025 US Tariff Shock. Such a loss loss requires a 61.6% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Arcus Biosciences (RCUS)

Arcus Biosciences (RCUS) is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative cancer therapies. Operating within the dynamic oncology sector, the company focuses on creating new treatment options by targeting novel biological pathways to combat various forms of cancer. Its headquarters are located in Hayward, California.

The company's pipeline features several investigational drugs, each designed to address specific aspects of cancer progression. Key assets include Etrumadenant, a dual adenosine receptor antagonist; Zimberelimab, an anti-PD-1 antibody; and Domvanalimab, an anti-TIGIT monoclonal antibody. Domvanalimab is a significant focus, particularly for first-line metastatic non-small cell lung cancer, often developed in combination with Zimberelimab, and is also being evaluated in a registrational Phase 3 trial in collaboration with AstraZeneca. Additionally, Arcus is advancing Quemliclustat, a CD73 inhibitor for pancreatic cancer, and AB521, a HIF-2a inhibitor for von Hippel-Lindau disease, among others.

Arcus Biosciences' business model centers on advancing these drug candidates through clinical trials with the goal of ultimately securing regulatory approval and commercialization. To accelerate its development efforts and expand its market reach, the company engages in strategic collaborations with partners such as AstraZeneca, Strata Oncology, Taiho Pharmaceutical, Abmuno Therapeutics, and WuXi Biologics. The primary customers and markets Arcus serves are patients battling various advanced cancers, including non-small cell lung cancer and pancreatic cancer, as well as those with specific conditions like von Hippel-Lindau disease, aiming to fulfill critical unmet medical needs in the global oncology landscape.

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1. An early-stage Genentech for cancer treatments.

2. A nascent Amgen, focused on developing new cancer drugs.

AI Analysis | Feedback

  • Etrumadenant: A dual A2a/A2b adenosine receptor antagonist in clinical trials for cancer therapy.
  • Zimberelimab: An anti-PD-1 antibody undergoing clinical trials as a monotherapy and in combination for cancer treatment.
  • Domvanalimab: An anti-TIGIT monoclonal antibody in clinical development, notably for non-small cell lung cancer in combination with other therapies.
  • Quemliclustat: A small-molecule CD73 inhibitor being studied in clinical trials for metastatic pancreatic cancer.
  • AB521: An oral and small molecule HIF-2a inhibitor in clinical studies for patients with von Hippel-Lindau disease.
  • Anti-CD39 Antibody: An investigational antibody being developed for the treatment of cancer through licensing agreements.

AI Analysis | Feedback

Arcus Biosciences (RCUS) is a clinical-stage biopharmaceutical company. As such, it does not currently sell therapies directly to individuals or healthcare providers. Instead, its primary business model involves collaborations, partnerships, and licensing agreements with other pharmaceutical and biotechnology companies for the development and potential commercialization of its drug candidates.

Based on the provided information, the major customer companies, in the form of collaboration and licensing partners, are:

  • Strata Oncology, Inc.
  • AstraZeneca (NASDAQ: AZN)
  • Taiho Pharmaceutical Co., Ltd
  • Abmuno Therapeutics LLC
  • WuXi Biologics (HKEX: 2269)

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  • WuXi Biologics (HKEX: 2269)
  • Strata Oncology, Inc.

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Terry Rosen, Chief Executive Officer

Dr. Terry Rosen co-founded Arcus Biosciences in 2015 and has served as its Chief Executive Officer since May 2015. He has over 30 years of experience leading drug discovery and development organizations in the biotechnology and pharmaceutical industries. Dr. Rosen also serves as a Director at PACT Pharma, Inc. and Epiodyne, Inc. and is on the boards of scientific institutions such as the Salk Institute Board of Trustees and the California Life Sciences Association.

Robert Goeltz, Chief Financial Officer

Mr. Robert Goeltz joined Arcus Biosciences as Chief Financial Officer on August 1, 2020. He possesses extensive financial leadership and operational experience in both large and small biopharmaceutical companies. Prior to Arcus, Mr. Goeltz served as Chief Financial Officer and Senior Vice President of UNITY Biotechnology and previously as Chief Financial Officer of CytomX Therapeutics, where he led both companies' initial public offerings (IPOs). He also spent 11 years at Amgen, where his roles included Chief Financial Officer of Onyx Pharmaceuticals following its acquisition by Amgen, as well as senior financial positions in commercial and R&D finance, business development, and accounting.

Juan Jaen, Co-Founder & President

Dr. Juan Jaen co-founded Arcus Biosciences in 2015 and serves as its President. With over 30 years of experience, he has been involved in all aspects of drug discovery and development. Before co-founding Arcus, Dr. Jaen was also the co-founder and President of Flexus Biosciences.

Jennifer Jarrett, Chief Operating Officer

Ms. Jennifer Jarrett holds the position of Chief Operating Officer at Arcus Biosciences.

Richard Markus, Chief Medical Officer

Dr. Richard Markus was appointed Chief Medical Officer of Arcus Biosciences effective January 31, 2025, bringing over 20 years of experience in biopharmaceuticals and clinical development. He previously held increasing roles of responsibility during a 13-year tenure at Amgen, including Vice President of Global Development, where he oversaw the development and approval of multiple products. Dr. Markus was also the first R&D head for Amgen's biosimilars division, leading the development of a 10-product pipeline. Most recently, he founded Dantari, a clinical-stage oncology-focused antibody-drug conjugate company, serving as its President, CEO, and board member.

AI Analysis | Feedback

The primary key risk to Arcus Biosciences is the inherent uncertainty and potential for failure in its extensive clinical trial pipeline, and the subsequent challenge of obtaining regulatory approval for any of its investigational products.

As a clinical-stage biopharmaceutical company, all of Arcus Biosciences' product candidates—including Etrumadenant, Zimberelimab, Domvanalimab, Quemliclustat, and AB521—are in various phases of clinical development and have not yet received regulatory approval for commercialization. There is a high risk that these clinical trials may not demonstrate sufficient safety or efficacy, or that regulatory bodies may not grant approval, which would prevent the company from bringing any products to market and generating significant revenue.

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Merck's belzutifan (Welireg), an oral HIF-2a inhibitor, is already approved for the treatment of patients with von Hippel-Lindau disease-associated tumors. Arcus Biosciences is developing AB521, an oral and small molecule HIF-2a inhibitor, which is in a Phase 1 study for the treatment of patients with von Hippel-Lindau disease. The established market presence of belzutifan presents a significant competitive threat to AB521's potential market entry and commercial viability.

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Here are the addressable market sizes for Arcus Biosciences' main products:

  • Domvanalimab (anti-TIGIT monoclonal antibody):
    • For first-line metastatic non-small cell lung cancer (NSCLC) and unresectable Stage III NSCLC: The global metastatic non-small cell lung cancer market size was estimated at USD 18.50 billion in 2025 and is projected to increase to approximately USD 50.30 billion by 2035. The non-small cell lung cancer market in the 7MM (United States, EU4, United Kingdom, and Japan) is projected to reach approximately USD 65 billion by 2034. The global TIGIT inhibitors market, which includes Domvanalimab, was estimated at USD 1.52 billion in 2025 and is projected to reach USD 4.98 billion by 2032. The United States holds the largest share of the TIGIT inhibitors market among the 7MM.
  • Zimberelimab (anti-PD-1 antibody):
    • The global PD-1 inhibitor drugs market size was USD 42.11 billion in 2024 and is predicted to increase to approximately USD 179.77 billion by 2034. Another source indicates the global PD-1 and PD-L1 inhibitors market size was valued at USD 48.7 billion in 2024 and is predicted to reach USD 166.9 billion by 2034.
  • Quemliclustat (small-molecule CD73 inhibitor):
    • For first-line metastatic pancreatic cancer: The global pancreatic cancer treatment market size was valued at USD 6.4 billion in 2024 and is expected to reach USD 12.4 billion by 2030. Another estimate places the global pancreatic cancer treatment market size at USD 3.82 billion in 2025, growing to USD 14.43 billion by 2034. The Pancreatic Cancer market size was valued at USD 3.28 billion in 2025 and is likely to cross USD 12.05 billion by 2035.
  • AB521 (oral and small molecule HIF-2a inhibitor):
    • For patients with von Hippel-Lindau disease: The global Von Hippel-Lindau Disease Market is estimated to be valued at USD 325.3 million in 2025 and is expected to reach USD 557.5 million by 2032. The global von Hippel-Lindau disease market reached US$ 293.47 million in 2023 and is expected to reach US$ 501.24 million by 2031. The total Von Hippel-Lindau Market Size in the 7MM (United States, EU4 countries, United Kingdom, and Japan) was around USD 300 million in 2023.

AI Analysis | Feedback

Arcus Biosciences (RCUS) is poised for potential revenue growth over the next 2-3 years, driven by its advancing clinical pipeline, strategic collaborations, and expansion into new therapeutic areas. Key drivers include:

  1. Commercialization and Pipeline Expansion of Casdatifan: Casdatifan, Arcus's HIF-2α inhibitor, is currently in Phase 3 trials for clear cell renal cell carcinoma (ccRCC) with the PEAK-1 study actively enrolling patients. Promising efficacy data from the ARC-20 study, showing a confirmed objective response rate (ORR) of 45% and a median progression-free survival (PFS) of 15.1 months in late-line ccRCC, suggests its potential as a best-in-class therapy. Arcus plans to initiate another Phase 3 trial for casdatifan in first-line metastatic kidney cancer by the end of 2026, further broadening its market opportunity. Additionally, Taiho Pharmaceutical Co., Ltd. has exercised its option for an exclusive license to casdatifan in Japan and other Asian territories, contributing milestone and royalty payments.
  2. Potential Approvals and Launch of Domvanalimab: Domvanalimab, an anti-TIGIT monoclonal antibody, is in late-stage development for various oncology indications. Pivotal data readouts for the STAR-221 study in gastric cancer and the ARC-10 study in non-small cell lung cancer are anticipated in 2025 and 2026, respectively, which could pave the way for commercialization. Positive data from the EDGE-Gastric trial, demonstrating strong survival benefits for domvanalimab-zimberelimab-chemotherapy in esophagogastric cancer, further supports its potential. Analysts have projected multi-billion dollar peak sales potential for successful TIGIT launches.
  3. Continued Revenue and Market Access through Gilead Collaboration: The strategic collaboration with Gilead Sciences remains a significant source of revenue for Arcus and provides crucial commercial infrastructure. This deep integration with Gilead facilitates market access and distribution scale across North America, Europe, and Asia. Collaboration revenue offers non-dilutive financial support, and expanding partnership income is expected to streamline the path to commercialization for Arcus's product candidates. Gilead increased its investment in Arcus in early 2024 to accelerate oncology programs.
  4. Advancement of Inflammation and Immunology (I&I) Pipeline: Arcus is expanding its therapeutic focus into inflammation and immunology, with two promising programs expected to enter clinical development in the near future. An oral MRGPRX2 antagonist for atopic dermatitis and chronic spontaneous urticaria is slated to enter clinical trials in 2026. Furthermore, an oral small-molecule TNF inhibitor, targeting rheumatoid arthritis, psoriasis, and inflammatory bowel disease, is expected to enter the clinic in late 2026 or early 2027. These I&I programs represent new avenues for revenue generation with large market potential.

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Share Issuance

  • In October 2025, Arcus Biosciences priced an underwritten public offering of 13,700,000 shares of its common stock at $18.25 per share, expecting gross proceeds of $250 million.
  • In February 2025, the company announced the pricing of an underwritten offering of 13,636,364 shares of its common stock at $11.00 per share, for total gross proceeds of approximately $150 million.
  • For the full year 2025, net proceeds from issuances of common stock were $429 million.

Inbound Investments

  • In early 2024, Gilead increased its stake to 33% by investing $320 million to accelerate Arcus's oncology programs.
  • Arcus established a 10-year collaboration with Gilead in May 2020, which included a significant capital investment and equity stake by Gilead. This collaboration was expanded in November 2021 and May 2023.
  • For the full year 2025, total revenue was $247 million, which included $23 million related to Gilead collaboration programs, $7 million from Taiho for exercising its option to casdatifan, and $3 million from Gilead's ongoing rights to access Arcus's research and development pipeline.

Capital Expenditures

  • Management has guided for disciplined research and development (R&D) spending of roughly $350–$400 million per year, with R&D being the primary focus of capital allocation.
  • For the fourth quarter of 2025, R&D expenses were $121 million, driven by increased late-stage trial activity. For the full year 2025, total R&D expenses contributed to a net loss of $353 million.
  • R&D expenses are expected to decrease meaningfully for the full year 2026 compared to 2025, with the exact magnitude dependent on the results of the futility analysis of the STAR-121 study. Arcus also anticipates advancing its first inflammation program into clinical development in 2026.

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Peer Comparisons

Peers to compare with:

Financials

RCUSVRTXAPMDATTOBLSMBRVEMedian
NameArcus Bi.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Mkt Price28.62496.0727.0020.1716.0030.0027.81
Mkt Cap3.6125.9----64.7
Rev LTM11712,587----6,352
Op Inc LTM-4864,777----2,145
FCF LTM-4753,796----1,661
FCF 3Y Avg-3611,957----798
CFO LTM-4744,293----1,909
CFO 3Y Avg-3532,398----1,023

Growth & Margins

RCUSVRTXAPMDATTOBLSMBRVEMedian
NameArcus Bi.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Rev Chg LTM-55.3%10.2%-----22.6%
Rev Chg 3Y Avg18.3%9.8%----14.1%
Rev Chg Q-74.4%12.5%-----31.0%
QoQ Delta Rev Chg LTM-50.4%3.0%-----23.7%
Op Inc Chg LTM-43.8%2,497.9%----1,227.1%
Op Inc Chg 3Y Avg-18.3%792.2%----387.0%
Op Mgn LTM-415.4%37.9%-----188.7%
Op Mgn 3Y Avg-218.3%23.9%-----97.2%
QoQ Delta Op Mgn LTM-246.7%-0.2%-----123.5%
CFO/Rev LTM-405.1%34.1%-----185.5%
CFO/Rev 3Y Avg-211.5%19.6%-----96.0%
FCF/Rev LTM-406.0%30.2%-----187.9%
FCF/Rev 3Y Avg-214.9%15.7%-----99.6%

Valuation

RCUSVRTXAPMDATTOBLSMBRVEMedian
NameArcus Bi.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
Mkt Cap3.6125.9----64.7
P/S30.810.0----20.4
P/Op Inc-7.426.3----9.5
P/EBIT-8.025.0----8.5
P/E-7.828.6----10.4
P/CFO-7.629.3----10.9
Total Yield-12.7%3.5%-----4.6%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-23.7%1.6%-----11.0%
D/E0.00.0----0.0
Net D/E-0.2-0.0-----0.1

Returns

RCUSVRTXAPMDATTOBLSMBRVEMedian
NameArcus Bi.Vertex P.Apnimed Attovia .BlossomH.Bravehea. 
1M Rtn-5.4%-0.5%8.0%20,169,900.0%0.0%0.7%0.3%
3M Rtn12.9%15.4%8.0%20,169,900.0%0.0%0.7%10.4%
6M Rtn36.1%3.8%8.0%10,084,900.0%0.0%0.7%5.9%
12M Rtn208.4%32.1%8.0%20,169,900.0%0.0%0.7%20.0%
3Y Rtn55.2%44.0%8.0%25,594.3%0.0%0.7%26.0%
1M Excs Rtn-7.3%-2.9%5.2%20,169,897.2%-2.8%-2.2%-2.5%
3M Excs Rtn9.8%11.0%2.3%20,169,894.3%-5.7%-5.1%6.0%
6M Excs Rtn28.8%-6.0%-6.1%10,084,885.9%-14.1%-13.4%-6.0%
12M Excs Rtn179.3%6.4%-14.3%20,169,877.7%-22.3%-21.6%-3.9%
3Y Excs Rtn-22.4%-33.5%-63.9%20,169,828.1%-71.9%-71.2%-48.7%

Comparison Analyses

null

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Developing and commercializing highly differentiated therapies that have a meaningful impact247258117112 
License and development services revenue    345
Other collaboration revenue    38
Total247258117112383


Net Income by Segment
$ Mil2025202420232022
Developing and commercializing highly differentiated therapies that have a meaningful impact-353-283-307-267
Total-353-283-307-267


Assets by Segment
$ Mil202520242022
Developing and commercializing highly differentiated therapies that have a meaningful impact1,1001,2001,300
Total1,1001,2001,300


Price Behavior

Price Behavior
Market Price$28.62 
Market Cap ($ Bil)3.6 
First Trading Date03/15/2018 
Distance from 52W High-7.9% 
   50 Days200 Days
DMA Price$26.87$23.48
DMA Trendupup
Distance from DMA6.5%21.9%
 3M1YR
Volatility54.7%62.2%
Downside Capture58.73117.37
Upside Capture98.79218.20
Correlation (SPY)36.3%37.0%
RCUS Betas & Captures as of 7/31/2026

 1M2M3M6M1Y3Y
Beta1.331.261.401.861.741.50
Up Beta5.792.802.431.622.191.63
Down Beta1.412.672.192.051.541.17
Up Capture-64%67%100%266%406%380%
Bmk +ve Days11223567138427
Stock +ve Days9243568141378
Down Capture71%-4%69%154%109%109%
Bmk -ve Days11212859114326
Stock -ve Days13192858110370

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RCUS
RCUS202.9%62.1%2.02-
Sector ETF (XLV)28.7%15.5%1.4216.5%
Equity (SPY)23.3%12.8%1.3636.7%
Gold (GLD)28.5%28.4%0.8719.4%
Commodities (DBC)32.9%19.8%1.32-0.2%
Real Estate (VNQ)14.2%13.8%0.725.3%
Bitcoin (BTCUSD)-44.2%42.9%-1.2324.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RCUS
RCUS-1.0%67.1%0.27-
Sector ETF (XLV)6.2%15.0%0.2332.4%
Equity (SPY)13.5%17.2%0.6139.1%
Gold (GLD)18.6%18.6%0.819.3%
Commodities (DBC)8.2%19.6%0.313.2%
Real Estate (VNQ)2.3%18.9%0.0229.6%
Bitcoin (BTCUSD)8.8%53.0%0.3520.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RCUS
RCUS5.8%76.0%0.41-
Sector ETF (XLV)10.1%16.6%0.4932.4%
Equity (SPY)15.4%17.9%0.7334.1%
Gold (GLD)12.1%16.2%0.618.4%
Commodities (DBC)7.4%18.0%0.339.8%
Real Estate (VNQ)4.8%20.7%0.2023.8%
Bitcoin (BTCUSD)58.2%66.2%0.9813.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date7152026
Short Interest: Shares Quantity12.6 Mil
Short Interest: % Change Since 6302026-0.7%
Average Daily Volume1.0 Mil
Days-to-Cover Short Interest12.9 days
Basic Shares Quantity126.1 Mil
Short % of Basic Shares10.0%

Earnings Returns History

Updated 8/8/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/5/20262.3%  
5/5/2026-0.2%-4.5%-5.3%
2/25/2026-3.6%11.9%4.6%
10/28/20252.1%-0.3%28.6%
8/6/2025-2.2%6.0%28.5%
5/6/2025-1.4%6.8%18.6%
2/25/2025-1.0%-5.4%-19.3%
11/6/20244.6%4.5%9.9%
...
SUMMARY STATS   
# Positive111217
# Negative14127
Median Positive5.8%10.7%15.6%
Median Negative-2.9%-4.9%-5.3%
Max Positive19.9%22.1%45.9%
Max Negative-10.6%-12.5%-19.3%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/5/20262.3%  
5/5/2026-0.2%-4.5%-5.3%
2/25/2026-3.6%11.9%4.6%
10/28/20252.1%-0.3%28.6%
8/6/2025-2.2%6.0%28.5%
5/6/2025-1.4%6.8%18.6%
2/25/2025-1.0%-5.4%-19.3%
11/6/20244.6%4.5%9.9%
8/8/202414.0%14.9%19.1%
5/8/20245.8%15.0%1.6%
2/21/202419.9%16.7%5.1%
11/7/2023-2.7%-12.5%-4.9%
8/7/2023-4.3%-4.3%15.6%
5/9/2023-3.0%-5.7%11.5%
2/28/2023-4.3%-3.0%-0.9%
11/2/2022-0.4%-1.0%45.9%
8/3/20221.9%2.5%-2.4%
5/9/202211.7%-8.0%9.9%
2/23/202218.6%22.1%15.7%
11/8/202112.0%9.6%27.1%
8/5/2021-10.6%-8.9%9.6%
5/5/2021-2.6%-5.8%-19.0%
2/24/2021-3.1%-2.2%-5.4%
11/5/2020-3.1%8.0%29.3%
8/6/20203.7%15.8%0.3%
SUMMARY STATS   
# Positive111217
# Negative14127
Median Positive5.8%10.7%15.6%
Median Negative-2.9%-4.9%-5.3%
Max Positive19.9%22.1%45.9%
Max Negative-10.6%-12.5%-19.3%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/05/202610-Q
03/31/202605/05/202610-Q
12/31/202502/25/202610-K
09/30/202510/28/202510-Q
06/30/202508/06/202510-Q
03/31/202505/06/202510-Q
12/31/202402/25/202510-K
09/30/202411/06/202410-Q
06/30/202408/08/202410-Q
03/31/202405/08/202410-Q
12/31/202302/21/202410-K
09/30/202311/07/202310-Q
06/30/202308/07/202310-Q
03/31/202305/09/202310-Q
12/31/202202/28/202310-K
09/30/202211/02/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/05/202610-Q
03/31/202605/05/202610-Q
12/31/202502/25/202610-K
09/30/202510/28/202510-Q
06/30/202508/06/202510-Q
03/31/202505/06/202510-Q
12/31/202402/25/202510-K
09/30/202411/06/202410-Q
06/30/202408/08/202410-Q
03/31/202405/08/202410-Q
12/31/202302/21/202410-K
09/30/202311/07/202310-Q
06/30/202308/07/202310-Q
03/31/202305/09/202310-Q
12/31/202202/28/202310-K
09/30/202211/02/202210-Q
06/30/202208/03/202210-Q
03/31/202205/09/202210-Q
12/31/202102/23/202210-K
09/30/202111/08/202110-Q
06/30/202108/05/202110-Q
03/31/202105/05/202110-Q
12/31/202002/25/202110-K
09/30/202011/05/202010-Q
06/30/202008/06/202010-Q
03/31/202005/05/202010-Q
12/31/201903/05/202010-K
09/30/201911/05/201910-Q

Recent Forward Guidance

Updated 8/6/2026

Latest: Q2 2026 Earnings Reported 8/5/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Revenue65.00 Mil70.00 Mil75.00 Mil21.7% RaisedGuidance: 57.50 Mil for 2026
2026 Cash 600.00 Mil 0 AffirmedGuidance: 600.00 Mil for 2026

Prior: Q1 2026 Earnings Reported 5/5/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Revenue50.00 Mil57.50 Mil65.00 Mil15.0% RaisedGuidance: 50.00 Mil for 2026
2026 Cash 600.00 Mil    

Q4 2025 Earnings Reported 2/25/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Revenue45.00 Mil50.00 Mil55.00 Mil-78.3% Lower NewGuidance: 230.00 Mil for 2025

Q3 2025 Earnings Reported 10/28/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2025 Revenue225.00 Mil230.00 Mil235.00 Mil0 AffirmedGuidance: 230.00 Mil for 2025

Insider Activity

Updated 7/13/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Jaen, Juan CPresidentTrustSell713202628.6220,067574,28823,531,306Form
2Jaen, Juan CPresidentTrustSell713202630.0548,5021,457,63125,313,852Form
3Jaen, Juan CPresidentTrustSell624202629.666,431190,74026,420,950Form
4Jaen, Juan CPresidentTrustSell624202627.7315,764437,10024,878,428Form
5Jaen, Juan CPresidentTrustSell624202627.039,236249,66124,679,685Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Jaen, Juan CPresidentTrustSell713202628.6220,067574,28823,531,306Form
2Jaen, Juan CPresidentTrustSell713202630.0548,5021,457,63125,313,852Form
3Jaen, Juan CPresidentTrustSell624202629.666,431190,74026,420,950Form
4Jaen, Juan CPresidentTrustSell624202627.7315,764437,10024,878,428Form
5Jaen, Juan CPresidentTrustSell624202627.039,236249,66124,679,685Form
6Azoy, AlexanderChief Accounting OfficerDirectSell601202625.772,56266,0241,020,018Form
7Goeltz, Ii Robert CChief Financial OfficerDirectSell512202625.637,763198,9662,157,046Form
8Jaen, Juan CPresidentTrustSell107202621.4131,823681,34219,745,488Form
9Goeltz, Ii Robert CChief Financial OfficerDirectSell102202623.386,552153,1861,588,063Form
10Azoy, AlexanderChief Accounting OfficerDirectSell1218202522.254,34396,614412,237Form
11Tang, Carolyn CGeneral CounselDirectSell1218202522.166,810150,9062,764,043Form
12Markus, RichardChief Medical OfficerDirectSell1218202522.164,49499,5851,454,705Form
13Azoy, AlexanderChief Accounting OfficerDirectSell1218202522.162,11346,823506,876Form
14Goeltz, Ii Robert CChief Financial OfficerDirectSell1218202522.165,960132,0711,650,351Form
15Jarrett, JenniferChief Operating OfficerDirectSell1218202522.169,983221,2184,277,315Form
16Jaen, Juan CPresidentDirectSell1218202522.169,983221,2187,667,453Form
17Rosen, Terry JChief Executive OfficerDirectSell1218202522.1625,744570,47448,635,870Form
18Tang, Carolyn CGeneral CounselDirectSell1218202521.887,658167,5902,878,748Form
19Markus, RichardChief Medical OfficerDirectSell1218202521.885,052110,5591,534,987Form
20Azoy, AlexanderChief Accounting OfficerDirectSell1218202521.882,37651,997546,823Form
21Goeltz, Ii Robert CChief Financial OfficerDirectSell1218202521.886,702146,6691,760,286Form
22Jarrett, JenniferChief Operating OfficerDirectSell1218202521.8811,225245,6514,442,666Form
23Jaen, Juan CPresidentDirectSell1218202521.8811,225245,6517,790,701Form
24Rosen, Terry JChief Executive OfficerDirectSell1218202521.8828,947633,48548,595,248Form
25Jaen, Juan CPresidentTrustSell1205202524.7182,9972,050,59923,571,939Form
26Azoy, AlexanderChief Accounting OfficerDirectSell1201202526.001,90049,400711,438Form
27Goeltz, Ii Robert CChief Financial OfficerDirectSell1126202525.005,000125,0002,178,450Form
28Jaen, Juan CPresidentTrustSell1119202519.755,05099,73820,481,935Form
29Jaen, Juan CPresidentTrustSell1119202520.3144,950913,02721,167,394Form
30Jarrett, JenniferChief Operating OfficerDirectSell1112202518.9750,291954,0664,064,174Form
31Jaen, Juan CPresidentTrustSell1103202520.324,31487,65022,086,342Form
32Jaen, Juan CPresidentTrustSell1030202520.9077,8401,626,63422,806,607Form
33Jaen, Juan CPresidentTrustSell1030202520.1919,019383,94423,603,391Form
34Goeltz, Ii Robert CChief Financial OfficerDirectSell1029202520.005,000100,0001,842,760Form
35Jarrett, JenniferChief Operating OfficerDirectSell1008202515.0537,792568,6113,223,292Form
36Jarrett, JenniferChief Operating OfficerDirectSell1008202514.5412,500181,8013,115,812Form
37Azoy, AlexanderChief Accounting OfficerDirectSell930202513.002,83136,803355,719Form
38Azoy, AlexanderChief Accounting OfficerDirectSell905202511.881,57918,758358,696Form

Investor Activity (13F)

Updated Aug 8, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Gilead Sciences, Inc.$678.8 Mil32.1%6Hold13F
Trails Edge Capital Partners, LP$22.6 Mil5.3%26ADD +14.4%13F
Decheng Capital LLC$10.3 Mil1.6%14TRIM -11.8%13F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Trails Edge Capital Partners, LP$22.6 Mil5.3%26ADD +14.4%13F
Active ManagerValue% of PortfolioTotal PositionsQoQAs OfFiling
First Turn Management, LLC$13.5 Mil1.5%33ExitedDec 31, 202513F
Decheng Capital LLC$10.3 Mil1.6%14TRIM -11.8%Mar 31, 202613F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Gilead Sciences, Inc.$678.8 Mil32.1%6Hold13F
Trails Edge Capital Partners, LP$22.6 Mil5.3%26ADD +14.4%13F
Decheng Capital LLC$10.3 Mil1.6%14TRIM -11.8%13F
Core Cache Last Updated: 8/7/2026