Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
Weak multi-year price returns
2Y Excs Rtn is -119%, 3Y Excs Rtn is -161%
Penny stock
Mkt Price is 0.2
1   Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
2   Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -36 Mil
3   Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 698%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -2831%
5   High stock price volatility
Vol 12M is 162%
6   Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 97%
7   Key risks
KALA key risks include [1] the complete discontinuation of its development platform following the pivotal trial failure of its lead candidate, Show more.
0 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Gene Editing & Therapy, Targeted Therapies, Show more.
1 Weak multi-year price returns
2Y Excs Rtn is -119%, 3Y Excs Rtn is -161%
2 Penny stock
Mkt Price is 0.2
3 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -36 Mil
5 Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 698%
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -2831%
7 High stock price volatility
Vol 12M is 162%
8 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 97%
9 Key risks
KALA key risks include [1] the complete discontinuation of its development platform following the pivotal trial failure of its lead candidate, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Kala Bio (KALA) stock has lost about 80% since 11/30/2025 because of the following key factors:

1. Continued Fallout from Failed Clinical Trial and Subsequent Strategic Shift.

Although the Phase 2b clinical trial for KPI-012 failed on September 29, 2025, its profound negative impact continued into and directly influenced the stock's severe decline during the specified period. This trial failure, which did not meet primary or key secondary endpoints for persistent corneal epithelial defect (PCED), led to the cessation of KPI-012 development and the mesenchymal stem cell secretome (MSC-S) platform, fundamentally eroding the company's previous valuation and necessitating a complete strategic overhaul. The company subsequently announced a strategic pivot in March 2026, focusing on deploying an on-premises AI infrastructure platform for the biotech industry with its "Researgency.AI" platform, signifying a drastic shift in its business model.

2. Severe Stock Dilution from Financing Activities.

To address critical financial needs and avert potential asset seizure, Kala Bio engaged in highly dilutive financing. This included a $6 million private placement of convertible preferred stock, with the initial $1.8 million closing in November 2025 and the remaining $4.2 million closing by January 2026 after stockholder approval. These preferred shares carried significant dilution potential, as the Series AA preferred stock was convertible into 49.5 million common shares and the Series AAA preferred stock into 882 million common shares, substantially increasing the outstanding share count. The company also obtained shareholder approval to increase authorized common stock to 1.5 billion shares and for a potential reverse stock split, further contributing to the dilution. Overall, total shares outstanding grew by 363.8% in the past year.

Show more

Stock Movement Drivers

Fundamental Drivers

The -81.8% change in KALA stock from 11/30/2025 to 3/29/2026 was primarily driven by a 0.0% change in the company's Shares Outstanding (Mil).
(LTM values as of)113020253292026Change
Stock Price ($)0.970.18-81.8%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)770.0%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

11/30/2025 to 3/29/2026
ReturnCorrelation
KALA-81.8% 
Market (SPY)-5.3%26.9%
Sector (XLV)-8.7%27.8%

Fundamental Drivers

The -98.4% change in KALA stock from 8/31/2025 to 3/29/2026 was primarily driven by a -7.5% change in the company's Shares Outstanding (Mil).
(LTM values as of)83120253292026Change
Stock Price ($)11.220.18-98.4%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)77-7.5%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 3/29/2026
ReturnCorrelation
KALA-98.4% 
Market (SPY)0.6%12.9%
Sector (XLV)5.2%-4.3%

Fundamental Drivers

The -97.5% change in KALA stock from 2/28/2025 to 3/29/2026 was primarily driven by a -34.3% change in the company's Shares Outstanding (Mil).
(LTM values as of)22820253292026Change
Stock Price ($)6.930.18-97.5%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)57-34.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2025 to 3/29/2026
ReturnCorrelation
KALA-97.5% 
Market (SPY)9.8%16.6%
Sector (XLV)-2.1%10.9%

Fundamental Drivers

The -98.3% change in KALA stock from 2/28/2023 to 3/29/2026 was primarily driven by a null change in the company's Total Revenues ($ Mil).
(LTM values as of)22820233292026Change
Stock Price ($)10.130.18-98.3%
Change Contribution By: 
Total Revenues ($ Mil)60 
P/S Multiple2.69.2233720368547763E17%
Shares Outstanding (Mil)17-78.7%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2023 to 3/29/2026
ReturnCorrelation
KALA-98.3% 
Market (SPY)69.4%15.9%
Sector (XLV)18.4%11.7%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
KALA Return-82%-37%-82%-1%-92%-64%-100%
Peers Return15%-69%112%37%126%-7%115%
S&P 500 Return27%-19%24%23%16%-5%72%

Monthly Win Rates [3]
KALA Win Rate25%25%42%42%42%0% 
Peers Win Rate45%38%43%47%63%27% 
S&P 500 Win Rate75%42%67%75%67%33% 

Max Drawdowns [4]
KALA Max Drawdown-83%-94%-86%-34%-92%-64% 
Peers Max Drawdown-28%-74%-42%-42%-40%-25% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-5% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: OCUL, EYPT, KOD, MGTX, LCTX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 3/27/2026 (YTD)

How Low Can It Go

Unique KeyEventKALAS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-99.2%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven12951.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-54.5%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven119.8%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-87.3%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven689.6%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days

Compare to OCUL, EYPT, KOD, MGTX, LCTX

In The Past

Kala Bio's stock fell -99.2% during the 2022 Inflation Shock from a high on 2/8/2021. A -99.2% loss requires a 12951.8% gain to breakeven.

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About Kala Bio (KALA)

Kala Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of therapies using its proprietary mucus penetrating particles technology for the treatment of eye diseases. The company's product candidates include KPI-012, which is in clinical development stage for the treatment of persistent corneal epithelial defects; EYSUVIS for the short-term treatment of the signs and symptoms of dry eye disease; and INVELTYS, a topical twice-a-day ocular steroid for the treatment of post-operative inflammation and pain following ocular surgery. Its preclinical development products comprise KPI-287 that inhibits the vascular endothelial and platelet derived growth factors for the treatment of retinal diseases, including wet age-related macular degeneration, diabetic macular edema, and retinal vein occlusion; and selective glucocorticoid receptor modulators program, a novel class of compounds to regulate gene expression through the transrepression pathway while avoiding the transactivation pathway. The company was formerly known as Hanes Newco, Inc. and changed its name to Kala Pharmaceuticals, Inc. in December 2009. Kala Pharmaceuticals, Inc. was incorporated in 2009 and is headquartered in Watertown, Massachusetts.

AI Analysis | Feedback

Here are 1-2 brief analogies for Kala Bio (KALA):

  1. Think of Kala Bio as a Moderna for eye diseases, applying a unique drug delivery technology to develop new therapies.

  2. Kala Bio is like a specialized, drug-focused Alcon or Bausch + Lomb, creating new prescription treatments for eye conditions using its proprietary technology.

AI Analysis | Feedback

  • KPI-012: A clinical-stage product candidate for the treatment of persistent corneal epithelial defects.
  • EYSUVIS: A therapy for the short-term treatment of the signs and symptoms of dry eye disease.
  • INVELTYS: A topical ocular steroid used for the treatment of post-operative inflammation and pain following ocular surgery.
  • KPI-287: A preclinical product designed to inhibit growth factors for the treatment of various retinal diseases, including wet age-related macular degeneration, diabetic macular edema, and retinal vein occlusion.
  • Selective Glucocorticoid Receptor Modulators Program: A preclinical program developing a novel class of compounds to regulate gene expression for therapeutic purposes.

AI Analysis | Feedback

Kala Bio (KALA) is a biopharmaceutical company that develops and commercializes therapies for eye diseases. As such, it does not sell its products directly to individual patients. Instead, its primary customers are other companies within the pharmaceutical supply chain that facilitate the distribution of prescription medications.

The major customers for Kala Bio, consistent with the business model of pharmaceutical companies, are typically large pharmaceutical wholesalers and distributors. These companies purchase drugs directly from manufacturers and then distribute them to pharmacies, hospitals, and clinics. While specific contractual details are proprietary, the following are the dominant pharmaceutical wholesalers in the United States, and thus would be the most likely major customers for a company like Kala Bio:

  • McKesson Corporation (NYSE: MCK)
  • AmerisourceBergen Corporation (NYSE: ABC)
  • Cardinal Health, Inc. (NYSE: CAH)

These distributors serve as critical intermediaries in getting Kala Bio's commercialized products, such as EYSUVIS and INVELTYS, to healthcare providers and ultimately to patients.

AI Analysis | Feedback

  • Ajinomoto Bio-Pharma Services (Ajinomoto Co., Inc., TYO: 2802)
  • Catalent Pharma Solutions LLC (Catalent, Inc., CTLT)
  • Recro Gainesville LLC (Recro Pharma, Inc., RECR)

AI Analysis | Feedback

Avi Minkowitz, Chief Executive Officer and Chief Financial Officer

Mr. Minkowitz was appointed Chief Executive Officer and Chief Financial Officer of KALA BIO, Inc. effective February 2, 2026. He brings experience in financing, mergers and acquisitions, business development, management consulting, and real estate acquisition and management. He also has prior board and entrepreneurial experience.

Darius Kharabi, Chief Business Officer

Mr. Kharabi has served as Chief Business Officer since November 2021. He co-founded and served as Chief Executive Officer of Combangio Inc., a clinical-stage ophthalmology mesenchymal stem cell secretome company that KALA BIO acquired in November 2021. Mr. Kharabi is also a co-founder and Chief Operating Officer of Lagunita Biosciences, LLC, an early-stage medical investment company. He has held board and executive leadership positions in multiple Lagunita portfolio companies, including xCella Biosciences (acquired by Ligand) and Kedalion Therapeutics (acquired by Novartis AG).

Kim Brazzell, Ph.D., Chief Medical Officer and Head of Research and Development

Dr. Brazzell has served as Chief Medical Officer at Kala Pharmaceuticals, Inc. since February 2013. He also served as a Principal of Acuity Advisors, LLC, an ophthalmic consulting company, from January 2014 to July 2018.

AI Analysis | Feedback

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1. Clinical Development and Regulatory Approval Risk: Kala Bio's business is highly dependent on the successful clinical development, regulatory approval, and commercialization of its product candidates, particularly KPI-012 for persistent corneal epithelial defects, which is in clinical development. The failure of clinical trials, delays in obtaining regulatory approvals, or inability to successfully launch and gain market acceptance for new therapies could significantly harm the company's financial condition and future prospects.

2. Commercialization and Competition Risk: Even with approved products like EYSUVIS for dry eye disease and INVELTYS for post-operative inflammation and pain, Kala Bio faces intense competition from established pharmaceutical companies with existing treatments and new therapies. The company's ability to achieve commercial success depends on its capacity to differentiate its products, secure market access, and gain widespread physician and patient adoption in a competitive ophthalmology market.

3. Intellectual Property Risk: Kala Bio relies on its proprietary mucus penetrating particles technology and product-specific patents to protect its intellectual property. The loss or expiration of key patents, challenges to their validity, or the inability to obtain new patent protection could expose the company to competition from generic or biosimilar products, thereby diminishing its market exclusivity and revenue potential.

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AI Analysis | Feedback

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AI Analysis | Feedback

Addressable Market Sizes for Kala Bio's Main Products

KPI-012 (Persistent Corneal Epithelial Defects - PCED)

The addressable market for Persistent Corneal Epithelial Defects (PCED) has an estimated incidence of approximately 100,000 patients in the U.S.. The global Persistent Corneal Epithelial Defects treatment market was valued at USD 1.44 billion in 2024 and is expected to reach USD 1.98 billion by 2032, growing at a CAGR of 4.05%. North America is anticipated to dominate this market, holding a 36.4% share. Another estimate indicates the total Persistent Epithelial Defects market size in the 7MM (United States, EU4 (Germany, France, Italy, and Spain), United Kingdom, and Japan) was approximately USD 274 million in 2023, with the U.S. market comprising approximately USD 183 million in the same year.

EYSUVIS (Dry Eye Disease)

The global dry eye syndrome market size was valued at USD 8.00 billion in 2025 and is projected to grow to USD 15.09 billion by 2034, exhibiting a CAGR of 7.37%. North America held the largest market share of 47.03% in 2025. Specifically, the U.S. dry eye syndrome market is projected to reach an estimated value of USD 5.60 billion by 2032. Another report estimates the dry eye disease market size in the 7MM was USD 3,759 million in 2023, with the U.S. accounting for approximately USD 2,739 million.

INVELTYS (Post-Operative Inflammation and Pain Following Ocular Surgery)

The global post-operative cataract surgery inflammation treatment market is estimated to be valued at USD 5.2 billion in 2025 and is projected to reach USD 10.0 billion by 2035, with a compound annual growth rate (CAGR) of 6.8%. The broader global ocular inflammation treatment market size was valued at USD 7.5 billion in 2023 and is set to exceed USD 11.4 billion by 2032, with North America dominating this market, reaching approximately USD 3 billion in 2023. Ocular surgeries in the United States were projected to reach approximately 10.1 million by 2024, highlighting the prevalence of procedures that can lead to post-operative inflammation.

KPI-287 (Retinal Diseases: Wet Age-Related Macular Degeneration, Diabetic Macular Edema, and Retinal Vein Occlusion)

The addressable market for KPI-287 includes several retinal diseases:
  • Wet Age-Related Macular Degeneration (Wet AMD): The global wet AMD market size across the top 7 markets (U.S., EU4, U.K., and Japan) was valued at USD 9,528.8 million in 2024 and is expected to reach USD 18,317.5 million by 2035. The market size in the 7MM was nearly USD 7,783 million in 2023, with the United States accounting for approximately 33% of that total, or about USD 2,599 million.
  • Diabetic Macular Edema (DME): The global diabetic macular edema market size reached USD 5.4 billion in 2023 and is expected to reach USD 7.5 billion by 2034. Other estimates place the global DME market at USD 4.2 billion in 2025, projected to reach USD 4.7 billion by 2035.
  • Retinal Vein Occlusion (RVO): The global retinal vein occlusion treatment market size was estimated at USD 2.48 billion in 2022 and is projected to reach USD 4.18 billion by 2030, with North America holding the largest revenue share of 41.20% in 2022. The U.S. retinal vein occlusion treatment industry reached USD 858.5 million in 2023. Another source estimates the global market at USD 3.01 billion in 2025, forecasted to reach USD 5.45 billion by 2034, with the North American market surpassing USD 1.18 billion in 2024. The total RVO market size in the 7MM was approximately USD 2,297.5 million in 2022, with the U.S. market at approximately USD 1,611.9 million in 2022.

Selective Glucocorticoid Receptor Modulators Program

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AI Analysis | Feedback

For Kala Bio (KALA), the primary expected driver of future revenue growth over the next 2-3 years centers around its strategic pivot into the artificial intelligence (AI) in healthcare market.

The key driver is:

  1. Commercialization of the Researgency.ai Platform: Kala Bio has launched Researgency.ai, an AI platform, and has entered into a licensing agreement with Younet AI. This initiative positions Kala Bio to tap into the global AI-in-healthcare market, which is projected to grow significantly. The company's vision for Researgency.ai, described as a "Palantir for biotech," aims to diversify revenue beyond its traditional drug pipeline. The success and adoption of this AI platform, including securing paying clients and establishing clear pricing, are expected to drive any future revenue growth for the company.

AI Analysis | Feedback

Share Issuance

  • Kala Pharmaceuticals completed a 1-for-50 reverse stock split on October 20, 2022, reducing outstanding common shares from approximately 73.2 million to about 1.46 million.
  • In December 2024, KALA BIO secured approximately $10.75 million from a private placement, selling common stock and Series I Convertible Non-Redeemable Preferred Stock to institutional investors.
  • KALA BIO engaged in multiple share issuances with investor David E. Lazar and other Series AAA investors in late 2025 and early 2026, including a first closing of a private placement for $1.8 million in November 2025 and a second closing for $4.2 million in January 2026 from the issuance of Series AA and Series AAA Preferred Stock.
  • In December 2025, KALA BIO completed a registered direct offering of 10,000,000 shares of common stock at $1.00 per share, generating approximately $10 million in gross proceeds.
  • In March 2026, KALA BIO agreed to issue 5,000,000 shares of its common stock to Younet AI as part of a platform development and exclusive license agreement.

Inbound Investments

  • KALA BIO received a $10.75 million private placement in December 2024 from institutional investors, including SR One, Cormorant Asset Management, and Woodline Partners, to fund operations and advance the clinical development of KPI-012.
  • Investor David E. Lazar made an initial investment of $1.8 million in November 2025 as part of a $6 million securities purchase agreement, with a further $4.2 million from Series AAA Preferred Shares expected following stockholder approval.
  • Kala Bio entered into a Convertible Loan Agreement with investor David Lazar for $375,000 in November 2025.

Capital Expenditures

  • In the last 12 months, capital expenditures for KALA BIO amounted to -$84,000.

Trade Ideas

Select ideas related to KALA.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
QDEL_2282026_Insider_Buying_45D_2Buy_200K02282026QDELQuidelOrthoInsiderInsider Buys 45DStrong Insider Buying
Companies with multiple insider buys in the last 45 days
0.0%0.0%0.0%
CHE_2272026_Dip_Buyer_FCFYield02272026CHEChemedDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
0.0%0.0%0.0%
LLY_2272026_Monopoly_xInd_xCD_Getting_Cheaper02272026LLYEli LillyMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.0%0.0%0.0%
HAE_2202026_Dip_Buyer_FCFYield02202026HAEHaemoneticsDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
3.5%3.5%0.0%
IQV_2132026_Dip_Buyer_ValueBuy02132026IQVIQVIADip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
7.1%7.1%-3.0%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

KALAOCULEYPTKODMGTXLCTXMedian
NameKala Bio Ocular T.EyePoint Kodiak S.MeiraGTx Lineage . 
Mkt Price0.187.5512.5037.007.621.497.58
Mkt Cap0.01.71.02.00.60.40.8
Rev LTM052310271521
Op Inc LTM-36-270-243-223-164-22-194
FCF LTM-32-217-243-127-121-19-124
FCF 3Y Avg-33-143-125-157-119-24-122
CFO LTM-32-205-240-127-116-19-121
CFO 3Y Avg-33-137-121-141-106-24-114

Growth & Margins

KALAOCULEYPTKODMGTXLCTXMedian
NameKala Bio Ocular T.EyePoint Kodiak S.MeiraGTx Lineage . 
Rev Chg LTM--18.5%-27.5%-96.8%53.2%17.4%
Rev Chg 3Y Avg-1.4%-7.4%-40.3%6.8%4.1%
Rev Chg Q--22.4%-94.6%--96.2%130.4%-58.5%
QoQ Delta Rev Chg LTM--6.9%-25.9%--27.7%34.6%-16.4%
Op Mgn LTM--519.8%-776.0%--597.9%-149.6%-558.8%
Op Mgn 3Y Avg--310.1%-425.4%--1,291.2%-217.4%-367.7%
QoQ Delta Op Mgn LTM--70.1%-260.3%--181.4%38.4%-125.8%
CFO/Rev LTM--394.4%-765.4%--424.1%-130.0%-409.2%
CFO/Rev 3Y Avg--242.0%-351.0%--904.2%-230.8%-296.5%
FCF/Rev LTM--417.5%-775.8%--441.5%-133.6%-429.5%
FCF/Rev 3Y Avg--253.8%-360.1%--1,053.9%-236.5%-307.0%

Valuation

KALAOCULEYPTKODMGTXLCTXMedian
NameKala Bio Ocular T.EyePoint Kodiak S.MeiraGTx Lineage . 
Mkt Cap0.01.71.02.00.60.40.8
P/S-32.433.1-22.524.328.3
P/EBIT-0.0-6.6-4.5-9.2-4.0-16.2-5.6
P/E-0.0-6.3-4.5-9.0-3.7-5.6-5.0
P/CFO-0.0-8.2-4.3-15.4-5.3-18.7-6.8
Total Yield-2,827.4%-15.8%-22.3%-11.1%-27.3%-18.0%-20.1%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-371.8%-12.6%-14.4%-53.3%-24.7%-13.3%-19.6%
D/E23.60.00.00.00.10.00.0
Net D/E7.0-0.4-0.3-0.00.1-0.2-0.1

Returns

KALAOCULEYPTKODMGTXLCTXMedian
NameKala Bio Ocular T.EyePoint Kodiak S.MeiraGTx Lineage . 
1M Rtn-53.8%-15.5%-28.8%38.1%0.8%-22.4%-19.0%
3M Rtn-73.0%-39.9%-31.7%23.8%-4.4%-9.7%-20.7%
6M Rtn-99.1%-39.7%-10.1%134.2%-6.8%-12.9%-11.5%
12M Rtn-97.1%-0.4%114.4%1,171.5%4.0%202.9%59.2%
3Y Rtn-98.8%46.3%290.6%508.1%46.8%4.2%46.6%
1M Excs Rtn-45.9%-13.5%-22.2%40.1%7.3%-16.2%-14.8%
3M Excs Rtn-64.4%-32.5%-23.4%27.2%0.3%-3.2%-13.3%
6M Excs Rtn-95.5%-34.7%-1.7%139.5%-3.4%-0.3%-2.5%
12M Excs Rtn-108.8%-13.1%94.8%1,117.7%-6.1%186.4%44.3%
3Y Excs Rtn-160.5%-6.1%361.2%584.2%-14.7%-53.0%-10.4%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Product revenues, net 41166
Total 41166


Assets by Segment
$ Mil20242023202220212020
Development and commercialization of innovative therapies for rare and severe diseases of the front5687   
Total5687   


Price Behavior

Price Behavior
Market Price$0.18 
Market Cap ($ Bil)0.0 
First Trading Date07/20/2017 
Distance from 52W High-99.1% 
   50 Days200 Days
DMA Price$0.39$3.87
DMA Trenddowndown
Distance from DMA-55.5%-95.5%
 3M1YR
Volatility118.6%162.7%
Downside Capture3.652.34
Upside Capture-4.48-98.82
Correlation (SPY)35.1%16.5%
KALA Betas & Captures as of 2/28/2026

 1M2M3M6M1Y3Y
Beta4.163.622.151.681.271.23
Up Beta3.751.363.444.300.750.92
Down Beta5.175.623.363.341.381.37
Up Capture133%155%-138%-202%-30%6%
Bmk +ve Days9203170142431
Stock +ve Days6142047103325
Down Capture561%418%348%226%157%111%
Bmk -ve Days12213054109320
Stock -ve Days14253974143413

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KALA
KALA-97.5%162.1%-0.93-
Sector ETF (XLV)0.3%17.6%-0.1310.5%
Equity (SPY)14.5%18.9%0.5916.8%
Gold (GLD)50.2%27.7%1.460.6%
Commodities (DBC)17.8%17.6%0.856.9%
Real Estate (VNQ)0.4%16.4%-0.1511.1%
Bitcoin (BTCUSD)-23.7%44.2%-0.497.3%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KALA
KALA-79.0%163.0%-0.27-
Sector ETF (XLV)6.0%14.5%0.235.7%
Equity (SPY)11.8%17.0%0.5410.2%
Gold (GLD)20.7%17.7%0.960.2%
Commodities (DBC)11.6%18.9%0.500.6%
Real Estate (VNQ)3.0%18.8%0.077.3%
Bitcoin (BTCUSD)4.0%56.6%0.292.9%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with KALA
KALA-57.8%132.6%-0.19-
Sector ETF (XLV)9.7%16.5%0.488.1%
Equity (SPY)14.0%17.9%0.6710.5%
Gold (GLD)13.3%15.8%0.701.1%
Commodities (DBC)8.2%17.6%0.392.0%
Real Estate (VNQ)4.7%20.7%0.197.3%
Bitcoin (BTCUSD)66.4%66.8%1.062.0%

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Short Interest

Short Interest: As Of Date3132026
Short Interest: Shares Quantity6.8 Mil
Short Interest: % Change Since 2282026600.0%
Average Daily Volume32.6 Mil
Days-to-Cover Short Interest1
Basic Shares Quantity7.0 Mil
Short % of Basic Shares97.0%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/8/20253.1%12.7%102.2%
3/31/2025-5.3%-29.9%-29.8%
11/12/2024-4.2%-10.8%-16.1%
8/6/20244.0%-0.8%1.2%
3/29/20241.5%-1.3%-19.7%
11/13/2023-0.6%-2.2%29.6%
8/4/2023-1.6%-4.6%-7.9%
3/3/202364.7%85.0%48.0%
...
SUMMARY STATS   
# Positive957
# Negative91311
Median Positive2.0%12.7%29.6%
Median Negative-5.3%-5.1%-12.4%
Max Positive64.7%85.0%102.2%
Max Negative-18.7%-29.9%-61.9%

SEC Filings

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Report DateFiling DateFiling
09/30/202511/19/202510-Q
06/30/202508/08/202510-Q
03/31/202505/14/202510-Q
12/31/202403/31/202510-K
09/30/202411/12/202410-Q
06/30/202408/06/202410-Q
03/31/202405/14/202410-Q
12/31/202303/29/202410-K
09/30/202311/13/202310-Q
06/30/202308/04/202310-Q
03/31/202305/09/202310-Q
12/31/202203/03/202310-K
09/30/202211/08/202210-Q
06/30/202208/11/202210-Q
03/31/202205/16/202210-Q
12/31/202103/29/202210-K

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Iwicki, Mark TDirectSell102420250.81154,894125,46483,867Form
2Reumuth, MaryCHIEF FINANCIAL OFFICERDirectSell102420250.8332,23026,75124,795Form
3Reumuth, MaryCHIEF FINANCIAL OFFICERDirectSell102420250.8296779323,703Form
4Bazemore, ToddDirectSell102420250.8347,76839,64729,824Form
5Brazzell, Romulus KSEE REMARKSDirectSell102420250.8346,74838,80129,840Form