Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -47%
Weak multi-year price returns
2Y Excs Rtn is -13%, 3Y Excs Rtn is -158%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -20 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -4089%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 186%
  Expensive valuation multiples
P/SPrice/Sales ratio is 198x
2   Stock price has recently run up significantly
6M Rtn6 month market price return is 163%
3   Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 288%
4   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -3451%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -3460%
5   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 622%
6   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -24%
7   High stock price volatility
Vol 12M is 137%
8   Key risks
IBIO key risks include [1] a history of significant losses and negative cash flow that raises going-concern doubts, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -47%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 186%
2 Weak multi-year price returns
2Y Excs Rtn is -13%, 3Y Excs Rtn is -158%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -20 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -4089%
4 Expensive valuation multiples
P/SPrice/Sales ratio is 198x
5 Stock price has recently run up significantly
6M Rtn6 month market price return is 163%
6 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 288%
7 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -3451%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -3460%
8 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 622%
9 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -24%
10 High stock price volatility
Vol 12M is 137%
11 Key risks
IBIO key risks include [1] a history of significant losses and negative cash flow that raises going-concern doubts, Show more.

Valuation, Metrics & Events

IBIO Stock


Why The Stock Moved


Qualitative Assessment

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1. Successful Public Offerings and Capital Infusion

iBio completed a $50 million public offering in August 2025, securing approximately $46.5 million in net proceeds. This funding, combined with an earlier $6.2 million raised through a warrant inducement transaction, was allocated to advance its preclinical cardiometabolic programs, specifically IBIO-610 and IBIO-600, and to support general corporate operations. This influx of capital notably bolstered the company's financial standing. 2. Promising Preclinical Data for Obesity Program (IBIO-610)

In October 2025, iBio released new non-human primate data for IBIO-610, an Activin E antibody, showcasing its significant therapeutic potential for fat-selective weight-loss and weight maintenance. Further compelling data supporting IBIO-610's differentiated approach to obesity treatment were presented at ObesityWeek 2025 and PEGS Europe 2025. These presentations highlighted its potential to achieve fat-selective weight loss, support long-term weight maintenance, and enhance the benefits of GLP-1 therapies. Show more

Stock Movement Drivers

Fundamental Drivers

The 134.7% change in IBIO stock from 9/25/2025 to 12/25/2025 was primarily driven by a 591.3% change in the company's P/S Multiple.
925202512252025Change
Stock Price ($)0.801.87134.72%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.400.5025.00%
P/S Multiple28.66198.15591.35%
Shares Outstanding (Mil)14.3952.98-268.18%
Cumulative Contribution-1553.38%

LTM = Last Twelve Months as of date shown

Market Drivers

9/25/2025 to 12/25/2025
ReturnCorrelation
IBIO134.7% 
Market (SPY)4.9%18.5%
Sector (XLV)16.2%-9.7%

Fundamental Drivers

The 163.4% change in IBIO stock from 6/26/2025 to 12/25/2025 was primarily driven by a 961.2% change in the company's P/S Multiple.
626202512252025Change
Stock Price ($)0.711.87163.38%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.380.5033.33%
P/S Multiple18.67198.15961.21%
Shares Outstanding (Mil)9.8652.98-437.22%
Cumulative Contribution-4871.52%

LTM = Last Twelve Months as of date shown

Market Drivers

6/26/2025 to 12/25/2025
ReturnCorrelation
IBIO163.4% 
Market (SPY)13.1%14.3%
Sector (XLV)16.6%3.2%

Fundamental Drivers

The -22.6% change in IBIO stock from 12/25/2024 to 12/25/2025 was primarily driven by a -513.7% change in the company's Shares Outstanding (Mil).
1225202412252025Change
Stock Price ($)2.421.87-22.58%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.170.50185.71%
P/S Multiple119.15198.1566.30%
Shares Outstanding (Mil)8.6352.98-513.70%
Cumulative Contribution-2065.70%

LTM = Last Twelve Months as of date shown

Market Drivers

12/25/2024 to 12/25/2025
ReturnCorrelation
IBIO-22.6% 
Market (SPY)15.8%17.3%
Sector (XLV)13.3%19.8%

Fundamental Drivers

The -78.3% change in IBIO stock from 12/26/2022 to 12/25/2025 was primarily driven by a -11883.9% change in the company's Shares Outstanding (Mil).
1226202212252025Change
Stock Price ($)8.601.87-78.25%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)1.800.50-72.22%
P/S Multiple2.11198.159283.10%
Shares Outstanding (Mil)0.4452.98-11883.94%
Cumulative Contribution-307238.55%

LTM = Last Twelve Months as of date shown

Market Drivers

12/26/2023 to 12/25/2025
ReturnCorrelation
IBIO32.6% 
Market (SPY)48.3%13.6%
Sector (XLV)18.5%16.5%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
IBIO Return322%-48%-97%-85%79%-23%-98%
Peers Return��-50%21%-33%12%�
S&P 500 Return16%27%-19%24%23%18%115%

Monthly Win Rates [3]
IBIO Win Rate50%42%25%33%50%50% 
Peers Win Rate�29%37%50%37%57% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
IBIO Max Drawdown-10%-48%-97%-87%-23%-77% 
Peers Max Drawdown��-62%-43%-48%-38% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: ABCL, RXRX, SDGR, RLAY, TWST. See IBIO Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/24/2025 (YTD)

How Low Can It Go

Unique KeyEventIBIOS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-99.9%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven111693.8%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-83.6%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven510.5%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-97.9%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven4670.6%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven236 days120 days
2008 Global Financial Crisis2008 Global Financial Crisis  
2008 Global Financial Crisis% Loss% Loss-94.7%-56.8%
2008 Global Financial Crisis% Gain to Breakeven% Gain to Breakeven1804.8%131.3%
2008 Global Financial CrisisTime to BreakevenTime to Breakeven604 days1,480 days

Compare to ACT, ALKS, LIVN, PRGO, PCRX

In The Past

iBio's stock fell -99.9% during the 2022 Inflation Shock from a high on 2/9/2021. A -99.9% loss requires a 111693.8% gain to breakeven.

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About iBio (IBIO)

iBio, Inc., a biotechnology company, provides contract development and manufacturing services to collaborators and third-party customers in the United States. The company operates in two segments: Biopharmaceuticals and Bioprocessing. Its lead therapeutic candidate is IBIO-100 that is being advanced for investigational new drug development for the treatment of systemic scleroderma and idiopathic pulmonary fibrosis. The company is also developing vaccine candidates comprising IBIO-200 and IBIO-201, which are in preclinical development for the prevention of severe acute respiratory syndrome coronavirus 2; and IBIO-400 for the treatment of classical swine fever. In addition, it is developing recombinant proteins for third parties on a catalog and custom basis; and offers a range of process development, manufacturing, filling and finishing, and bio analytic services. iBio, Inc. has a license agreement with Planet Biotechnology, Inc. to develop therapeutics for infectious diseases; collaboration agreement with The Texas A&M University System for the development of coronavirus disease 2019 vaccine candidates; license agreement with the University of Natural Resources and Life Sciences, Vienna; and collaboration agreement with CC-Pharming Ltd. The company is headquartered in Bryan, Texas.

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Moderna for plant-based biologics.

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  • Fibrosis Therapeutics: Developing biologic drug candidates like IBIO-101 for the treatment of fibrotic diseases such as systemic scleroderma.
  • Oncology Therapeutics: Researching and developing novel therapeutic candidates for cancer leveraging an AI-powered discovery platform.
  • Vaccine Candidates: Utilizing their proprietary plant-based platform for the rapid development of vaccine candidates.
  • Biopharmaceutical CDMO Services: Offering contract development and manufacturing services to other companies using their proprietary *FastPharming* plant-based expression system for biologics.

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iBio (symbol: IBIO) primarily operates in a business-to-business (B2B) model, providing contract development and manufacturing organization (CDMO) services and engaging in research and development collaborations within the biopharmaceutical industry.

Based on iBio's public financial disclosures (e.g., 10-K filings), no single customer has accounted for 10% or more of the company's total revenue in recent fiscal years. As such, iBio does not publicly disclose specific names of individual major customers as per SEC regulations. This indicates a diversified customer base within its B2B operations.

Therefore, while specific customer company names are not publicly available due to revenue diversification, iBio's customers generally fall into the following categories:

  • Biopharmaceutical Companies: This category encompasses a wide range of companies, from small, emerging biotechnology startups focused on drug discovery and development to larger, established pharmaceutical companies. These customers typically engage iBio for its FastPharming® platform to develop and manufacture biologics, including antibodies, vaccines, and other protein-based therapeutics for preclinical and clinical trials.
  • Academic and Research Institutions: Universities, medical centers, and other non-profit research organizations often collaborate with iBio for specialized protein production, process development, and manufacturing services to advance their research programs and early-stage drug candidates.
  • Government Agencies and NGOs: Occasionally, government bodies or non-governmental organizations may contract with iBio for specific research, development, or manufacturing projects, particularly in areas related to public health initiatives, infectious diseases, or biodefense.

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Martin B. Brenner, Chief Executive Officer and Chief Scientific Officer

Dr. Brenner has a strong history of success leading drug discovery and development teams at several prominent pharmaceutical companies, including AstraZeneca, Eli Lilly and Company, Pfizer Inc., and Merck Research Laboratories. He most recently served as the Chief Scientific Officer at Pfenex Inc., a company that developed therapeutic equivalents, vaccines, biologics, and biosimilars using its patented technology, which was acquired by Ligand Pharmaceuticals Incorporated for approximately $516 million in October 2020. Dr. Brenner was appointed interim CEO of iBio in January 2023 and became the permanent CEO in June 2023.

Felipe Duran, Chief Financial Officer

Mr. Duran previously served as iBio's Vice President of Financial Planning and Analysis (FP&A) from April 2021 to February 2023. From 2016 to 2021, he held the position of Executive Director (CFO) of Lupin Latin America, a subsidiary of Lupin Pharmaceuticals, where he significantly increased regional net sales through robust commercial pricing strategies and led the subsidiary to become an EBITDA-positive business. His prior experience also includes various strategy roles at Teva Pharmaceuticals and working as an FP&A Manager for Bupa and Noven Pharmaceuticals. Mr. Duran was appointed interim CFO in February 2023 and permanently assumed the role in June 2023.

Marc Banjak, Chief Legal Officer

Mr. Banjak brings over 15 years of experience in the biotechnology and contract research industries to iBio. He previously served as the first general counsel for both Istari Oncology and Dova Pharmaceuticals, and at Dova, he provided legal and compliance guidance through key milestones, including its acquisition by Swedish Orphan Biovitrum AB.

Kristi Sarno, Senior Vice President of Business Development

Ms. Sarno began her tenure as the Senior Vice President of Business Development in 2024.

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Here are the key risks to iBio's business:
  1. Financial Health and Going Concern: iBio has a history of significant losses and negative cash flow, requiring continuous external financing to fund its operations and research and development efforts. The company reported a consolidated net loss of $65.0 million for the fiscal year ended June 30, 2023. Its operating margin is substantially negative at -4089.4%. The company consistently relies on issuing new stock and warrants to raise capital, indicating a potential ongoing concern regarding its ability to generate sufficient revenue to sustain operations independently.
  2. Product Development and Commercialization Risk: As a biotechnology company, iBio's success is heavily dependent on its ability to successfully develop, obtain regulatory approvals for, and commercialize its product candidates. The generation of significant revenue is contingent on numerous factors, including setting acceptable product prices, securing adequate reimbursement, establishing effective sales, marketing, manufacturing, and distribution systems, achieving broad market acceptance, and protecting its intellectual property portfolio. There are inherent risks and uncertainties in the development and manufacturing of these product candidates, making the prediction of future revenue generation uncertain. Concerns have also been raised regarding slow pipeline progress.
  3. Shareholder Dilution: Directly linked to its funding needs, iBio's strategy of raising capital through the issuance of new shares and warrants poses a significant risk of dilution for existing shareholders. The company has a substantial number of stock options outstanding, which represent future potential dilution if exercised. This ongoing dilution is a necessary measure to fund expensive research and development but can reduce the ownership percentage and value of existing shares.

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One clear emerging threat to iBio (IBIO) is the rapid advancement and potential industrial scalability of Cell-Free Protein Synthesis (CFPS) technologies.

CFPS systems offer a paradigm shift in protein manufacturing by producing proteins outside of living cells. These systems promise significantly faster development timelines, simpler purification processes, and potentially lower costs compared to traditional cell-based expression systems, including iBio's proprietary plant-based FastPharming platform. While CFPS technologies are still maturing for large-scale production of complex biologics, ongoing advancements in yield, efficiency, and platform engineering by various academic institutions and biotech companies (such as Arbor Biosciences and others exploring industrial applications) pose a direct competitive threat. Should CFPS platforms become robust, high-yield, and cost-effective for large-scale manufacturing of therapeutic proteins, they could undermine the speed, flexibility, and cost advantages that iBio currently promotes for its unique plant-based manufacturing solution across various applications, including vaccines and antibody production.

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iBio (IBIO) focuses on developing biopharmaceutical products and providing contract development and manufacturing organization (CDMO) services. Their main product areas include immuno-oncology, fibrotic diseases, and cardiometabolic diseases, particularly obesity, leveraging their proprietary antibody discovery platform and FastPharming® System.

Addressable Markets:

  • Immuno-Oncology: The global immuno-oncology market was estimated at USD 43.73 billion in 2023 and is projected to reach approximately USD 284.29 billion by 2033, growing at a Compound Annual Growth Rate (CAGR) of 23.12% from 2024 to 2033. A broader global oncology market was valued at USD 234.6 billion in 2023 and is anticipated to reach USD 533.2 billion by 2032, with a CAGR of 9.6%. More specifically, the global cancer biologics market was USD 110.91 billion in 2024 and is projected to reach USD 232.02 billion by 2034, with a CAGR of 7.66%.
  • Fibrotic Diseases (specifically Idiopathic Pulmonary Fibrosis - IPF): The global fibrotic diseases treatment market is expected to grow from USD 5.79 billion in 2024 to USD 10.35 billion by 2032, at a CAGR of 7.6%. The global idiopathic pulmonary fibrosis (IPF) treatment market was valued at USD 4.103.66 million in 2024 and is expected to reach USD 7.315.80 million by 2033, exhibiting a CAGR of 6.30% during 2025-2033. North America currently holds a significant share of this market, with the United States accounting for 88.2% of the North American IPF treatment market in 2024.
  • Rare Diseases: The global rare diseases treatment market was valued at USD 224.30 billion in 2024 and is projected to reach USD 527.05 billion by 2034, with an expected CAGR of 8.92% from 2025 to 2034. North America dominated this market with a 49% revenue share in 2024. The U.S. rare diseases treatment market alone was estimated at USD 76.93 billion in 2024 and is predicted to be around USD 184.68 billion by 2034, growing at a CAGR of 9.15% from 2025 to 2034.
  • Contract Development and Manufacturing Organization (CDMO) Services: The global CDMO market size was valued at USD 238.92 billion in 2024 and is projected to grow to USD 465.24 billion by 2032, exhibiting a CAGR of 9.0%. North America held the largest share of this market, at 38.59% (USD 92.22 billion) in 2024. Focusing on biologics, the global biologics CDMO market reached USD 25.32 billion in 2025 and is forecast to attain USD 36.51 billion by 2030, advancing at a 7.59% CAGR. North America controlled 34.54% of the biologics CDMO market share in 2024.

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iBio (IBIO) is poised for potential revenue growth over the next 2-3 years, driven primarily by advancements in its preclinical pipeline and strategic initiatives in precision antibody therapies. The key drivers include:

  1. Advancement and Potential Commercialization of Lead Cardiometabolic and Obesity Candidates: iBio is heavily focused on its cardiometabolic and obesity pipeline, with lead candidates IBIO-610 (an Activin E-targeting antibody) and IBIO-600 (a long-acting anti-myostatin antibody). Preclinical data for IBIO-610 has demonstrated a 26% fat mass reduction without lean mass loss in mice, while IBIO-600 has shown extended half-life and dose-dependent muscle growth in non-human primates. The company aims to move these candidates into clinical investigation, with plans for obesity and cardiometabolic disorders in 2026, which could be a significant revenue driver if successful.
  2. Expansion of the Pipeline through Strategic Collaborations: iBio's strategic collaborations, such as the one with AstralBio, have been instrumental in expanding its pipeline. This collaboration has led to the discovery of novel targets, including an amylin receptor antibody, further diversifying iBio's therapeutic portfolio in cardiometabolic diseases. Such partnerships can generate collaboration revenue and provide additional product candidates for future development and commercialization.
  3. Launch of New Product Candidates, including Bispecific Antibodies: Beyond its lead candidates, iBio is actively developing new product modalities, notably a bispecific antibody program targeting myostatin/activin A. This program is also slated for clinical investigation in obesity and cardiometabolic disorders in 2026, representing a potential new class of therapies and a fresh avenue for revenue generation.
  4. Leveraging its AI-Driven Drug Discovery Platform: iBio's proprietary AI-driven drug discovery platform, which includes technologies like its Machine-Learning Antibody Engine, EngageTx, ShieldTx, StableHu, and AI epitope steering technology, is a core asset. This platform aims to accelerate the discovery and development of precision antibody therapies for various hard-to-treat diseases, including obesity and cancer, thereby continuously feeding its pipeline with new, innovative product opportunities that can drive long-term revenue growth.

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Share Issuance

  • In August 2025, iBio completed a public offering, generating initial gross proceeds of approximately $50 million, before deducting underwriting discounts and commissions and offering expenses. The offering included pre-funded warrants and accompanying Series G and H warrants.
  • If all Series G and Series H warrants issued in the August 2025 offering are exercised in full for cash, iBio could receive an additional $50 million in gross proceeds, potentially bringing the total gross proceeds to $100 million.
  • In September 2025, iBio raised $6.2 million in gross proceeds through a warrant inducement transaction with institutional investors, which strengthened the company's balance sheet and provided additional working capital.

Inbound Investments

  • In January 2025, iBio completed a private placement offering that raised over $650,000 from members of its Board of Directors and Officers.

Better Bets than iBio (IBIO)

Trade Ideas

Select ideas related to IBIO. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
21.1%21.1%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-6.7%-6.7%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
16.7%16.7%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
11.8%11.8%-5.1%

Recent Active Movers

More From Trefis

Peer Comparisons for iBio

Peers to compare with:

Financials

IBIOABCLRXRXSDGRRLAYTWSTMedian
NameiBio AbCeller.Recursio.Schrodin.Relay Th.Twist Bi. 
Mkt Price1.873.724.4018.388.6533.586.53
Mkt Cap0.11.12.01.41.52.01.4
Rev LTM03543257837739
Op Inc LTM-20-247-724-170-327-136-209
FCF LTM-17-153-450-3-249-76-114
FCF 3Y Avg-20-140-354-104-269-105-122
CFO LTM-17-105-441-1-248-48-76
CFO 3Y Avg-19-73-339-96-266-85-91

Growth & Margins

IBIOABCLRXRXSDGRRLAYTWSTMedian
NameiBio AbCeller.Recursio.Schrodin.Relay Th.Twist Bi. 
Rev Chg LTM185.7%7.2%-32.8%32.9%-16.5%20.3%13.7%
Rev Chg 3Y Avg112.8%-39.7%23.2%15.7%448.1%22.8%23.0%
Rev Chg Q-37.6%-80.9%53.9%-16.9%27.3%
QoQ Delta Rev Chg LTM25.0%7.4%-32.7%8.0%0.0%3.9%5.7%
Op Mgn LTM-4,089.4%-699.7%-1,666.6%-66.3%-3,914.4%-36.2%-1,183.2%
Op Mgn 3Y Avg-22,214.9%-661.1%-980.6%-89.2%-3,096.7%-58.9%-820.9%
QoQ Delta Op Mgn LTM561.1%102.7%-659.5%14.8%191.2%3.1%58.7%
CFO/Rev LTM-3,450.8%-296.0%-1,016.2%-0.4%-2,973.4%-12.6%-656.1%
CFO/Rev 3Y Avg-18,919.5%-215.8%-686.3%-49.1%-2,271.9%-30.4%-451.0%
FCF/Rev LTM-3,460.2%-433.4%-1,037.0%-1.3%-2,978.3%-20.1%-735.2%
FCF/Rev 3Y Avg-21,229.3%-389.7%-715.3%-53.0%-2,288.8%-37.2%-552.5%

Valuation

IBIOABCLRXRXSDGRRLAYTWSTMedian
NameiBio AbCeller.Recursio.Schrodin.Relay Th.Twist Bi. 
Mkt Cap0.11.12.01.41.52.01.4
P/S198.131.545.35.3178.55.438.4
P/EBIT-5.0-4.5-2.8-7.9-4.6-15.5-4.8
P/E-4.9-6.5-2.7-7.7-5.0-26.1-5.7
P/CFO-5.7-10.6-4.5-1,207.0-6.0-42.6-8.3
Total Yield-20.3%-15.4%-36.4%-13.0%-20.0%-3.8%-17.7%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-158.5%-13.7%-18.5%-6.6%-27.6%-7.2%-16.1%
D/E0.00.10.00.10.00.00.0
Net D/E-0.5-0.3-0.3-0.2-0.4-0.1-0.3

Returns

IBIOABCLRXRXSDGRRLAYTWSTMedian
NameiBio AbCeller.Recursio.Schrodin.Relay Th.Twist Bi. 
1M Rtn59.8%2.8%0.7%5.3%7.5%7.9%6.4%
3M Rtn134.7%-20.0%-5.0%-3.4%97.5%25.5%11.1%
6M Rtn163.4%-0.5%-18.5%-10.3%160.5%-9.1%-4.8%
12M Rtn-22.6%26.1%-39.2%-6.8%104.5%-31.3%-14.7%
3Y Rtn-78.3%-64.0%-41.4%-2.5%-40.8%44.8%-41.1%
1M Excs Rtn65.1%0.8%-1.8%4.0%2.5%11.1%3.3%
3M Excs Rtn129.8%-25.0%-9.9%-8.4%92.5%20.6%6.1%
6M Excs Rtn150.5%-13.4%-31.4%-23.2%147.7%-22.0%-17.7%
12M Excs Rtn-41.5%13.6%-43.9%-22.3%91.1%-46.8%-31.9%
3Y Excs Rtn-158.0%-144.2%-123.8%-84.9%-126.8%-40.4%-125.3%

Financials

Segment Financials

Assets by Segment
$ Mil20252024202320222021
Preclinical stage biotechnology company leveraging Artificial Intelligence (AI) and machine learning2941990 
Biopharmaceuticals   175104
Bioprocessing   3632
Eliminations   -64-41
Total29419914794


Price Behavior

Price Behavior
Market Price$1.87 
Market Cap ($ Bil)0.0 
First Trading Date08/19/2008 
Distance from 52W High-70.8% 
   50 Days200 Days
DMA Price$1.43$1.33
DMA Trenddownup
Distance from DMA30.6%40.6%
 3M1YR
Volatility171.9%137.6%
Downside Capture-215.72146.40
Upside Capture234.7499.72
Correlation (SPY)19.5%17.4%
IBIO Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta3.372.132.051.721.141.27
Up Beta3.001.051.120.630.531.05
Down Beta7.887.735.775.382.031.90
Up Capture86%205%204%123%61%15%
Bmk +ve Days13263974142427
Stock +ve Days10233258109316
Down Capture368%-83%-6%8%137%110%
Bmk -ve Days7162452107323
Stock -ve Days10193167137404

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of IBIO With Other Asset Classes (Last 1Y)
 IBIOSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-22.7%16.4%19.2%71.9%8.9%6.0%-10.1%
Annualized Volatility136.7%17.3%19.5%19.3%15.3%17.1%35.0%
Sharpe Ratio0.490.720.782.690.360.18-0.12
Correlation With Other Assets 19.6%17.3%-4.4%6.7%20.6%4.5%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
 Comparison of IBIO With Other Asset Classes (Last 5Y)
 IBIOSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-67.9%8.6%14.9%18.7%11.7%4.8%32.7%
Annualized Volatility154.2%14.5%17.1%15.5%18.7%18.9%48.7%
Sharpe Ratio-0.120.410.700.970.510.170.60
Correlation With Other Assets 11.2%13.3%3.1%2.6%12.8%7.8%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of IBIO With Other Asset Classes (Last 10Y)
 IBIOSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-51.8%9.8%14.7%14.9%6.9%5.2%69.3%
Annualized Volatility155.5%16.6%18.0%14.8%17.6%20.8%55.8%
Sharpe Ratio0.110.480.700.830.310.220.90
Correlation With Other Assets 4.9%5.8%-1.4%0.4%3.3%2.3%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date12152025
Short Interest: Shares Quantity3,906,126
Short Interest: % Change Since 11302025100.6%
Average Daily Volume22,914,016
Days-to-Cover Short Interest1
Basic Shares Quantity52,981,000
Short % of Basic Shares7.4%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/12/2025-8.0%-12.8%46.4%
8/18/2025-1.3%13.9%13.5%
5/2/2025-1.9%-19.4%-20.3%
2/10/2025-7.3%7.6%62.3%
9/20/2024-6.1%5.6%56.9%
5/13/20243.6%18.4%40.5%
9/21/2023-1.6%-11.3%1.6%
9/27/2022-32.3%-44.1%-72.9%
...
SUMMARY STATS   
# Positive157
# Negative1397
Median Positive3.6%7.6%40.5%
Median Negative-7.0%-13.3%-21.9%
Max Positive3.6%18.4%62.3%
Max Negative-32.3%-44.1%-72.9%

SEC Filings

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Report DateFiling DateFiling
93020251112202510-Q 9/30/2025
6302025905202510-K 6/30/2025
3312025502202510-Q 3/31/2025
12312024210202510-Q 12/31/2024
93020241112202410-Q 9/30/2024
6302024920202410-K 6/30/2024
3312024513202410-Q 3/31/2024
12312023209202410-Q 12/31/2023
93020231114202310-Q 9/30/2023
6302023927202310-K 6/30/2023
3312023515202310-Q 3/31/2023
12312022214202310-Q 12/31/2022
93020221114202210-Q 9/30/2022
63020221011202210-K 6/30/2022
3312022512202210-Q 3/31/2022
12312021214202210-Q 12/31/2021