DiaMedica Therapeutics (DMAC)


Market Price (10/6/2026): $8.44 | Market Cap: $454.9 MilSector: Health Care | Industry: Biotechnology

DiaMedica Therapeutics (DMAC)


Market Price (10/6/2026): $8.44
Market Cap: $454.9 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.

Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 10%

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -39 Mil

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14%

Significant short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 36.67

Key risks
DMAC key risks include [1] its overwhelming dependence on the clinical trial success of its sole lead product candidate, Show more.

0 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.
1 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 10%
2 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -39 Mil
4 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14%
5 Significant short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 36.67
6 Key risks
DMAC key risks include [1] its overwhelming dependence on the clinical trial success of its sole lead product candidate, Show more.

DMAC in ETFs

Weight = DMAC's share of each fund

IWM0.01%
IWO0.02%
VTWO0.01%

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 10/1/2026

DiaMedica Therapeutics (DMAC) stock has gained about 20% since 6/30/2026 because of the following key factors:

1. Positive Interim Results in Phase 2 Preeclampsia Trial. DiaMedica Therapeutics reported positive interim results from Part 1a of its Phase 2 study evaluating DM199 in preeclampsia. These results, announced with the company's fiscal Q2 2026 earnings on August 10, 2026, demonstrated rapid, clinically meaningful, and statistically significant reductions in maternal blood pressure. This favorable clinical data contributed to an upward revision of analyst share price targets from $10 to $12.

2. Advancements in Fetal Growth Restriction (FGR) Program. The company completed enrollment in the first cohort of an investigator-sponsored Phase 2 early-onset FGR trial in June 2026. Dosing commenced in the second cohort by September 2026, and DiaMedica announced preliminary positive safety and tolerability results from the first six participants, with a virtual event scheduled in October 2026 to discuss these findings.

Show more
Updated on 10/1/2026

DiaMedica Therapeutics (DMAC) stock has gained about 20% since 6/30/2026 because of the following key factors:

1. Positive Interim Results in Phase 2 Preeclampsia Trial. DiaMedica Therapeutics reported positive interim results from Part 1a of its Phase 2 study evaluating DM199 in preeclampsia. These results, announced with the company's fiscal Q2 2026 earnings on August 10, 2026, demonstrated rapid, clinically meaningful, and statistically significant reductions in maternal blood pressure. This favorable clinical data contributed to an upward revision of analyst share price targets from $10 to $12.

2. Advancements in Fetal Growth Restriction (FGR) Program. The company completed enrollment in the first cohort of an investigator-sponsored Phase 2 early-onset FGR trial in June 2026. Dosing commenced in the second cohort by September 2026, and DiaMedica announced preliminary positive safety and tolerability results from the first six participants, with a virtual event scheduled in October 2026 to discuss these findings.

3. Progress Toward Interim Analysis in Acute Ischemic Stroke (AIS) Trial. DiaMedica confirmed continued progress in its pivotal Phase 2/3 ReMEDy2 trial for acute ischemic stroke (AIS). Enrollment reached 75% of the 200-patient threshold required to trigger a planned interim analysis, which is now anticipated in fiscal Q1 2027. This milestone was initially announced in May 2026 and reiterated in the fiscal Q2 2026 business update.

4. Extended Cash Runway. DiaMedica Therapeutics reported a cash, cash equivalents, and short-term investments balance of $43.5 million as of June 30, 2026. The company stated that this cash position is anticipated to fund its planned clinical studies and support corporate operations through 2027, providing financial stability and reducing near-term capital raise concerns.

5. Strong Analyst Sentiment and Price Targets. Throughout the period, analysts maintained a consensus "Buy" or "Strong Buy" rating for DMAC stock, reflecting positive sentiment regarding the company's clinical pipeline. Average price targets ranged from $12.00 to $18.50, suggesting significant potential upside. For example, HC Wainwright maintained a "Buy" rating with a $12 price target on August 11, 2026.

Show less
Holding a concentrated position? Know your true downside before the momentum shifts.
Protect Your Wealth →

Stock Movement Drivers

Fundamental Drivers

The 19.6% change in DMAC stock from 6/30/2026 to 10/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)630202610052026Change
Stock Price ($)7.048.4219.6%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)5454-0.2%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2026 to 10/5/2026
ReturnCorrelation
DMAC19.6% 
Market (SPY)3.8%30.0%
Sector (XLV)5.5%16.2%

Fundamental Drivers

The 24.4% change in DMAC stock from 3/31/2026 to 10/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)331202610052026Change
Stock Price ($)6.778.4224.4%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)5254-2.7%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2026 to 10/5/2026
ReturnCorrelation
DMAC24.4% 
Market (SPY)19.4%28.1%
Sector (XLV)14.7%17.6%

Fundamental Drivers

The 22.6% change in DMAC stock from 9/30/2025 to 10/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)930202510052026Change
Stock Price ($)6.878.4222.6%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)4354-20.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 10/5/2026
ReturnCorrelation
DMAC22.6% 
Market (SPY)17.3%35.0%
Sector (XLV)21.8%21.1%

Fundamental Drivers

The 226.4% change in DMAC stock from 9/30/2023 to 10/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)930202310052026Change
Stock Price ($)2.588.42226.4%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple∞∞0.0%
Shares Outstanding (Mil)2754-49.3%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2023 to 10/5/2026
ReturnCorrelation
DMAC226.4% 
Market (SPY)87.5%27.3%
Sector (XLV)36.1%18.9%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
DMAC Return-63%-58%80%91%47%3%-19%
Peers Return-18%18%36%16%33%2%108%
S&P 500 Return27%-19%24%23%16%13%106%

Monthly Win Rates [3]
DMAC Win Rate25%42%50%67%67%40% 
Peers Win Rate40%43%48%45%58%44% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
DMAC Max Drawdown-70%-71%-53%-41%-49%-39% 
Peers Max Drawdown-54%-45%-44%-46%-40%-34% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: BIIB, AMGN, TVTX, AKBA, ARDX.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 10/5/2026 (YTD)

How Low Can It Go

EventDMACS&P 500
2025 US Tariff Shock
  % Loss-49.2%-18.8%
  % Gain to Breakeven96.7%23.1%
  Time to Breakeven153 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-36.7%-9.5%
  % Gain to Breakeven58.0%10.5%
  Time to Breakeven206 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-69.8%-24.5%
  % Gain to Breakeven231.6%32.4%
  Time to Breakeven258 days427 days
2020 COVID-19 Crash
  % Loss-58.2%-33.7%
  % Gain to Breakeven139.1%50.9%
  Time to Breakeven85 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-49.0%-19.2%
  % Gain to Breakeven96.2%23.8%
  Time to Breakeven425 days105 days
2013 Taper Tantrum
  % Loss-14.4%-0.2%
  % Gain to Breakeven16.8%0.2%
  Time to Breakeven1784 days1 days

Compare to BIIB, AMGN, TVTX, AKBA, ARDX

In The Past

DiaMedica Therapeutics's stock fell -49.2% during the 2025 US Tariff Shock. Such a loss loss requires a 96.7% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventDMACS&P 500
2025 US Tariff Shock
  % Loss-49.2%-18.8%
  % Gain to Breakeven96.7%23.1%
  Time to Breakeven153 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-36.7%-9.5%
  % Gain to Breakeven58.0%10.5%
  Time to Breakeven206 days24 days
2022 Inflation Shock & Fed Tightening
  % Loss-69.8%-24.5%
  % Gain to Breakeven231.6%32.4%
  Time to Breakeven258 days427 days
2020 COVID-19 Crash
  % Loss-58.2%-33.7%
  % Gain to Breakeven139.1%50.9%
  Time to Breakeven85 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-49.0%-19.2%
  % Gain to Breakeven96.2%23.8%
  Time to Breakeven425 days105 days

Compare to BIIB, AMGN, TVTX, AKBA, ARDX

In The Past

DiaMedica Therapeutics's stock fell -49.2% during the 2025 US Tariff Shock. Such a loss loss requires a 96.7% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About DiaMedica Therapeutics (DMAC)

DiaMedica Therapeutics (DMAC) is a clinical-stage biopharmaceutical company dedicated to discovering and developing novel treatments for patients afflicted with neurological and kidney diseases. Based in Minneapolis, Minnesota, the company focuses its research and development efforts on conditions with significant unmet medical needs.

The company's primary asset is DM199, a recombinant human tissue kallikrein-1 protein, which is currently in advanced clinical development. DM199 is being evaluated in a Phase 2 trial (REDUX) for individuals with moderate to severe chronic kidney disease stemming from Type I or Type II diabetes, addressing a critical need in nephrology. Concurrently, it's also in Phase 2/3 trials (REMEDY2) for the treatment of acute ischemic stroke, targeting a significant neurological condition. Beyond DM199, DiaMedica is also developing DM300, a preclinical-stage candidate aimed at inflammatory diseases, indicating a broader future interest in the immunology market.

AI Analysis | Feedback

Here are a few analogies for DiaMedica Therapeutics (DMAC):

  • It's like an early-stage Biogen, focused on developing innovative drugs for neurological and kidney diseases.
  • Think of it as a clinical-stage Vertex Pharmaceuticals, striving to bring its first breakthrough therapies for kidney and neurological conditions to market.

AI Analysis | Feedback

  • DM199: A recombinant human tissue kallikrein-1 protein in clinical trials for chronic kidney disease and acute ischemic stroke.
  • DM300: A drug candidate in the pre-clinical stage for the treatment of inflammatory diseases.

AI Analysis | Feedback

As a clinical-stage biopharmaceutical company, DiaMedica Therapeutics Inc. (DMAC) is primarily focused on the research and development of drug candidates, conducting clinical trials, and seeking regulatory approvals. The company has not yet commercialized any products. Therefore, DiaMedica Therapeutics does not currently have major customers in the traditional sense of companies or individuals purchasing its products.

AI Analysis | Feedback

The major suppliers for DiaMedica Therapeutics are:

  • Wuxi Biologics Holdings Inc. (Symbol: 2269.HK)
  • Novotech (Australia) Pty Limited

AI Analysis | Feedback

Rick Pauls - President and Chief Executive Officer Mr. Pauls was appointed President and Chief Executive Officer of DiaMedica Therapeutics Inc. in 2009 and has served as a director since 2005. He also served as Chairman of the Board from 2008 to 2014. Before joining DiaMedica, Mr. Pauls co-founded and served as Managing Director of CentreStone Ventures, an early-stage life sciences venture capital fund, from 2002 to 2010. He was also an analyst for Centara Corporation, another early-stage venture capital fund, from 2000 to 2002. Scott Kellen - Chief Financial Officer and Secretary Mr. Kellen joined DiaMedica Therapeutics in January 2018 as Vice President of Finance and was appointed Chief Financial Officer and Secretary in April 2018. Prior to DiaMedica, Mr. Kellen was Vice President and Chief Financial Officer of Sun BioPharma, Inc., a publicly-traded clinical-stage drug development company, from 2015 to 2018. From 2010 to 2015, he served as Chief Financial Officer and Secretary of Kips Bay Medical, Inc., a publicly-traded medical device company, also becoming its Chief Operating Officer in 2012. Mr. Kellen has over 25 years of experience in the life sciences industry, focusing on publicly traded early-stage and growth companies. Julie Krop, M.D. - Chief Medical Officer Dr. Krop was appointed Chief Medical Officer effective August 2025. She brings over 20 years of experience as a strategic physician executive in both pre-commercial and commercial organizations across various therapeutic and orphan indications. Before DiaMedica, Dr. Krop served as CMO and Head of Development at PureTech Health. Previously, she was CMO at Freeline Therapeutics, where she contributed to a successful IPO and oversaw gene therapy programs. Dr. Krop also held the role of CMO and Executive Vice President at AMAG Pharmaceuticals, where she was involved in the approval of three drugs. Ambarish Shah, Ph.D. - Chief Technology Officer Dr. Shah was appointed Chief Technology Officer effective September 2023. He has more than 25 years of experience in advancing biopharmaceuticals from early development to commercialization. Before joining DiaMedica, Dr. Shah was Vice President and Head of Global Vaccines Development at CSL Seqirus, where he was responsible for end-to-end chemistry, manufacturing, and control (CMC) in vaccine development. Prior to that, he was Executive Director, Head of Drug Product Development at Bristol-Myers Squibb (formerly Celgene). Dominic Cundari - Chief Commercial Officer Mr. Cundari was appointed Chief Commercial Officer effective February 2022. He has over 30 years of pharmaceutical experience in various commercial roles within high-growth markets. Before joining DiaMedica, Mr. Cundari worked as an independent commercial strategy and development consultant for Genentech since 2009. From 1988 to 2009, he held various sales and marketing management positions at Genentech.

AI Analysis | Feedback

DiaMedica Therapeutics (DMAC), as a clinical-stage biopharmaceutical company, faces inherent and significant risks primarily centered on the successful development and commercialization of its drug candidates. The key risks to the business are:

1. Clinical Trial Risk

The most significant risk for DiaMedica Therapeutics is the uncertainty surrounding the outcome of its ongoing and future clinical trials for lead drug candidate DM199 (for chronic kidney disease, acute ischemic stroke, and preeclampsia) and pre-clinical stage DM300. The success of DiaMedica's business hinges entirely on these trials demonstrating efficacy and safety. There is a substantial risk of a sharp stock decline if DM199 clinical trials fail. Existing preclinical and earlier clinical data may not be predictive of the results of ongoing or later clinical trials, and unexpected adverse events or delays can significantly impact the company's prospects. For instance, the ReMEDy2 trial for acute ischemic stroke experienced a clinical hold due to transient acute hypotension, highlighting the potential for unforeseen challenges in the trial process. Safety concerns, including potential adverse events like angioedema and oral candidiasis, could also hinder patient acceptance and regulatory approval.

2. Regulatory Approval Risk

Following successful clinical trials, DiaMedica Therapeutics must navigate complex and uncertain regulatory approval processes with health authorities such as the FDA and Health Canada. Even if clinical data is positive, there is no guarantee that regulatory bodies will grant approval for its drug candidates. Failure to reproduce positive outcomes in larger, more diverse populations during later-stage trials could lead to delays or limitations in regulatory approvals, which would consequently cap or delay potential revenue and earnings.

3. Financing Risk / Cash Burn

As a company without revenue generation from approved products, DiaMedica Therapeutics relies heavily on its ability to raise sufficient capital to fund its extensive and costly research and development activities, particularly its clinical trials. The company faces continuous cash burn, necessitating future additional funding. While DiaMedica has reported cash, cash equivalents, and investments that are anticipated to provide a runway into the second half of 2027 (as of late 2025/early 2026 reports), delays in clinical timelines or the need for additional studies could require further capital, potentially leading to shareholder dilution. The cash burn rate increased by 43% in the last year, indicating that the actual cash runway could be shorter if this trend of increasing expenditure continues.

AI Analysis | Feedback

null

AI Analysis | Feedback

DiaMedica Therapeutics (DMAC) is developing treatments for neurological and kidney diseases with its lead drug candidate, DM199, and is also developing DM300 for inflammatory diseases.

DM199 Addressable Markets

  • Chronic Kidney Disease Caused by Type I or Type II Diabetes (Diabetic Nephropathy): The global diabetic kidney disease market was valued at approximately USD 3.03 billion in 2024 and is projected to reach USD 4.21 billion by 2031. The U.S. diabetic nephropathy market is estimated to reach USD 1.59 billion by 2032.
  • Acute Ischemic Stroke: The global acute ischemic stroke therapeutics market size was valued at USD 9.13 billion in 2024 and is projected to grow to USD 19.35 billion by 2033.

DM300 Addressable Markets

  • Inflammatory Diseases: The global inflammatory diseases biologics market size was approximately USD 99.06 billion in 2024 and is expected to reach USD 157.31 billion by 2033. North America holds a significant share of this market.

AI Analysis | Feedback

DiaMedica Therapeutics Inc. (DMAC), a clinical-stage biopharmaceutical company, anticipates its future revenue growth over the next 2-3 years to be primarily driven by the successful development and potential commercialization of its lead drug candidate, DM199. The key drivers include:

  1. Advancement and Potential Approval of DM199 for Acute Ischemic Stroke (AIS): DM199 is currently in Phase 2/3 REMEDY2 trials for the treatment of acute ischemic stroke. Analysts project significant revenue for DiaMedica Therapeutics in 2027 and 2028, with forecasts ranging up to $609 million and $2.3 billion, respectively, which is contingent on the successful commercialization of DM199 for this indication. An interim analysis for the ReMEDy2 stroke trial is anticipated in the second half of 2026.
  2. Advancement and Potential Approval of DM199 for Preeclampsia and Fetal Growth Restriction: DiaMedica Therapeutics is also progressing DM199 through Phase 2 trials for preeclampsia and fetal growth restriction. The company aims to complete the expansion cohort of its preeclampsia trial in the first half of 2026 and subsequently initiate a U.S. Phase 2 trial. Preeclampsia is identified as a critically underserved area with substantial unmet medical needs and a large commercial opportunity, positioning DM199 as a potential first-in-class treatment.
  3. Geographic Expansion and Market Penetration of DM199: The company's ReMEDy2 trial for acute ischemic stroke is undergoing global expansion, having secured regulatory clearance in the U.K. and with anticipated expansion into Europe. Broader geographical reach for DM199, following regulatory approvals, would contribute to a larger addressable market and subsequent revenue growth.
  4. Successful Achievement of Clinical Milestones and Regulatory Approvals for DM199: The realization of future revenue growth is fundamentally dependent on the successful completion of ongoing clinical trials for DM199 in both acute ischemic stroke and preeclampsia, followed by obtaining the necessary regulatory approvals. These milestones are critical precursors to any market entry and commercial sales.

AI Analysis | Feedback

Share Issuance

  • DiaMedica Therapeutics closed a private placement of common shares in July 2025, resulting in net proceeds of approximately $29.9 million from the sale of about 8.6 million common shares at $3.50 per share.
  • The company filed a Form S-8 registering 1,000,000 common shares for issuance under its 2021 Employment Inducement Incentive Plan, with the Board amending the plan in July 2025 to reserve an additional 1,000,000 shares for equity awards as inducement to employment.
  • DiaMedica Therapeutics reported 52 million shares outstanding in Q3 2025, an increase of 0.8% from the prior quarter, indicating ongoing share issuance.

Inbound Investments

  • In July 2025, DiaMedica Therapeutics received approximately $29.9 million in net proceeds from a private placement of common shares to accredited investors, which included approximately $16.8 million from certain non-management related parties.
  • A significant shareholder, Jan Stahlberg, purchased 1,061,277 shares valued at $7,624,976 in DiaMedica Therapeutics in December 2025.
  • Paragon Associates & Paragon Associates II Joint Venture increased its stake in DiaMedica by 34.6% in Q3, buying 225,000 shares to hold 875,000 shares, valued at approximately $6.01 million.

Capital Expenditures

  • DiaMedica Therapeutics reported capital expenditures of $16K in Q3 2025, primarily for funding long-term assets and infrastructure.
  • For the last 12 months, capital expenditures were reported at -$41,000.
  • Annual capital expenditures were consistently low, reported as $0.0 million in 2020, 2021, 2023, and 2024, and -$0.1 million in 2022.

Peer Outperformance in Biotechnology

DMAC has outperformed 88% of its 361 Biotechnology peers over 5Y. Biotechnology ranks 10th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that DMAC has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
68%
of 453 industry peers · 19.1% return
3Y
88%
of 401 industry peers · 272.6% return
5Y
88%
of 361 industry peers · 114.8% return
No Biotechnology peer with a comparable growth profile has beaten DMAC by more than 20pp over 5Y.
Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is DMAC's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 14.7%44.5%95.9% CAH 430% · MCK 373% · COR 184%
Health Care Services 20 20.9%37.4%12.4% HIMS 303% · RDNT 151% · DGX 78%
Managed Health Care 8 29.4%-8.1%6.6% OSCR 97% · HQY 44% · ELV 15%
Health Care Facilities 24 -1.3%5.7%0.6% THC 310% · NHC 282% · ENSG 137%
Health Care Equipment 50 -7.3%-0.8%-15.1% POCI 11050% · UFPT 393% · GKOS 259%
Pharmaceuticals 62 -8.2%-7.2%-31.0% INDV 1108% · ETON 1073% · LQDA 920%
Health Care Supplies 12 22.1%-5.5%-37.0% LNTH 304% · HAE 57% · MMSI 21%
Life Sciences Tools & Services 108 -0.4%-11.1%-65.3% SNWV 1818% · NTRA 283% · MEDP 222%
Health Care Technology 21 -31.5%-57.4%-78.2% SPOK 80% · HSTM 14% · VEEV 0%
Biotechnology ← 362 -15.2%-23.6%-78.9% CELZ 1214% · DNTH 1126% · ELVN 1113%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Latest Trefis Analyses

TitleDate
0DASHBOARDS 
1DiaMedica Therapeutics Earnings Notes12/16/2025
Title
0ARTICLES

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

DMACBIIBAMGNTVTXAKBAARDXMedian
NameDiaMedic.Biogen Amgen Travere .Akebia T.Ardelyx  
Mkt Price8.44223.59401.8357.670.913.4033.05
Mkt Cap0.533.0217.05.40.20.83.1
Rev LTM010,02838,095591219451521
Op Inc LTM-391,93511,426-40-13-35-24
FCF LTM-322,49010,1751529-1822
FCF 3Y Avg-261,9358,754-175-4-53-15
CFO LTM-322,87912,4789342-1767
CFO 3Y Avg-262,26010,312-1040-52-13

Growth & Margins

DMACBIIBAMGNTVTXAKBAARDXMedian
NameDiaMedic.Biogen Amgen Travere .Akebia T.Ardelyx  
Rev Chg LTM-0.3%9.1%77.1%7.5%16.8%9.1%
Rev Chg 3Y Avg-0.2%12.8%70.8%3.7%84.7%12.8%
Rev Chg Q-3.4%9.5%48.2%-21.4%23.8%9.5%
QoQ Delta Rev Chg LTM-0.9%2.4%10.3%-5.7%5.4%2.4%
Op Inc Chg LTM-24.7%-21.7%39.5%76.3%-1,766.4%12.2%-4.7%
Op Inc Chg 3Y Avg-31.4%-6.0%12.3%42.9%-534.6%10.4%2.2%
Op Mgn LTM-19.3%30.0%-6.8%-6.0%-7.9%-6.0%
Op Mgn 3Y Avg-21.5%24.5%-90.9%-8.6%-15.5%-8.6%
QoQ Delta Op Mgn LTM--3.9%1.6%3.8%-8.3%0.9%0.9%
CFO/Rev LTM-28.7%32.8%15.7%19.0%-3.8%19.0%
CFO/Rev 3Y Avg-22.8%29.3%-60.5%-1.5%-19.4%-1.5%
FCF/Rev LTM-24.8%26.7%2.6%13.4%-4.0%13.4%
FCF/Rev 3Y Avg-19.5%24.9%-86.5%-3.4%-19.7%-3.4%

Valuation

DMACBIIBAMGNTVTXAKBAARDXMedian
NameDiaMedic.Biogen Amgen Travere .Akebia T.Ardelyx  
Mkt Cap0.533.0217.05.40.20.83.1
P/S-3.35.79.11.11.93.3
P/Op Inc-11.617.119.0-133.2-18.7-23.8-15.1
P/EBIT-11.625.516.7-93.6-23.5-31.5-17.5
P/E-12.139.624.8-124.0-8.3-15.1-10.2
P/CFO-14.411.517.458.25.9-48.78.7
Total Yield-8.3%2.5%6.4%-0.8%-12.1%-6.6%-3.7%
Dividend Yield0.0%0.0%2.4%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-9.4%7.2%4.9%-23.9%-0.9%-3.9%-2.4%
D/E0.00.30.30.10.20.30.2
Net D/E-0.10.20.20.0-0.4-0.0-0.0

Returns

DMACBIIBAMGNTVTXAKBAARDXMedian
NameDiaMedic.Biogen Amgen Travere .Akebia T.Ardelyx  
1M Rtn25.0%1.2%-8.1%-11.7%-6.2%-10.1%-7.1%
3M Rtn5.4%7.3%10.3%0.3%-29.6%-36.3%2.8%
6M Rtn27.5%29.7%18.9%81.2%-30.7%-43.0%23.2%
12M Rtn19.4%39.8%38.6%134.1%-67.7%-35.4%29.0%
3Y Rtn273.5%-15.1%64.4%658.8%-13.7%-14.4%25.3%
1M Excs Rtn28.3%-0.7%-9.9%-13.7%-7.3%-8.7%-8.0%
3M Excs Rtn2.0%5.1%6.2%-3.9%-36.4%-40.4%-0.9%
6M Excs Rtn9.9%12.2%1.3%63.6%-48.4%-60.7%5.6%
12M Excs Rtn4.8%28.3%23.1%122.3%-82.1%-51.0%14.0%
3Y Excs Rtn146.1%-94.1%-18.2%461.4%-99.5%-96.9%-56.2%

Comparison Analyses

null

Financials

Segment Financials

Revenue by Segment
$ Mil2018
Development of its drug product candidate DM199 for the treatment of severe ischemic disease0
Total0


Operating Income by Segment
$ Mil202520242023
Development of its drug product candidate DM199 for the treatment of severe ischemic disease-34-27-21
Total-34-27-21


Net Income by Segment
$ Mil202520242023
Development of its drug product candidate DM199 for the treatment of severe ischemic disease-33-24-19
Total-33-24-19


Assets by Segment
$ Mil20232022202120202019
Development of its drug product candidate DM199 for the treatment of severe ischemic disease543446289
Total543446289


Price Behavior

Price Behavior
Market Price$8.42 
Market Cap ($ Bil)0.5 
First Trading Date06/01/2009 
Distance from 52W High-10.3% 
   50 Days200 Days
DMA Price$6.93$7.08
DMA Trenddownup
Distance from DMA21.6%18.9%
 3M1YR
Volatility42.6%56.3%
Downside Capture83.57176.22
Upside Capture96.17165.59
Correlation (SPY)31.7%35.0%
DMAC Betas & Captures as of 9/30/2026

 1M2M3M6M1Y3Y
Beta1.231.031.251.101.521.22
Up Beta1.530.851.431.091.811.16
Down Beta4.013.152.970.480.780.84
Up Capture227%172%119%138%233%410%
Bmk +ve Days6162766132424
Stock +ve Days13212961117356
Down Capture-235%-76%35%125%140%107%
Bmk -ve Days16263760120328
Stock -ve Days7173161129376

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with DMAC
DMAC20.4%56.1%0.53-
Sector ETF (XLV)18.5%15.7%0.8821.6%
Equity (SPY)16.8%13.0%0.9235.1%
Gold (GLD)7.0%29.6%0.2316.4%
Commodities (DBC)45.9%20.9%1.71-10.5%
Real Estate (VNQ)1.6%13.6%-0.1415.7%
Bitcoin (BTCUSD)-30.1%44.3%-0.6824.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with DMAC
DMAC14.8%74.0%0.50-
Sector ETF (XLV)6.8%15.2%0.2614.0%
Equity (SPY)13.3%17.2%0.5920.6%
Gold (GLD)18.3%18.9%0.786.3%
Commodities (DBC)10.0%19.6%0.391.1%
Real Estate (VNQ)0.9%18.8%-0.0616.3%
Bitcoin (BTCUSD)14.9%52.2%0.4512.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with DMAC
DMAC10.2%81.1%0.52-
Sector ETF (XLV)10.5%16.7%0.5115.0%
Equity (SPY)15.4%17.9%0.7319.9%
Gold (GLD)11.5%16.4%0.573.8%
Commodities (DBC)8.4%18.1%0.387.3%
Real Estate (VNQ)4.1%20.7%0.1616.7%
Bitcoin (BTCUSD)64.0%66.2%1.0410.5%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date9152026
Short Interest: Shares Quantity5.5 Mil
Short Interest: % Change Since 83120261.7%
Average Daily Volume0.1 Mil
Days-to-Cover Short Interest36.7 days
Basic Shares Quantity53.9 Mil
Short % of Basic Shares10.2%

Earnings Returns History

Updated 9/11/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/10/20263.3%-0.5%-0.9%
5/6/20260.2%-4.0%-13.5%
11/12/2025-14.1%15.7%37.4%
8/12/202514.9%10.5%39.5%
5/13/20250.5%3.9%-2.0%
3/17/2025-13.0%-17.4%-41.4%
11/13/2024-3.3%-5.6%26.3%
8/7/20243.1%7.1%24.0%
...
SUMMARY STATS   
# Positive111212
# Negative121111
Median Positive3.3%8.9%22.5%
Median Negative-5.5%-6.9%-12.1%
Max Positive14.9%40.8%59.0%
Max Negative-14.1%-28.4%-41.4%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/10/20263.3%-0.5%-0.9%
5/6/20260.2%-4.0%-13.5%
11/12/2025-14.1%15.7%37.4%
8/12/202514.9%10.5%39.5%
5/13/20250.5%3.9%-2.0%
3/17/2025-13.0%-17.4%-41.4%
11/13/2024-3.3%-5.6%26.3%
8/7/20243.1%7.1%24.0%
5/8/2024-6.3%-13.3%-26.2%
3/19/2024-1.8%-3.5%-11.7%
11/13/20236.8%3.4%13.7%
8/14/20234.4%2.8%14.1%
5/15/2023-10.8%40.8%59.0%
3/28/2023-3.3%7.2%4.6%
11/9/2022-1.6%-1.6%16.3%
8/10/20229.8%5.8%-12.1%
5/4/20222.8%-6.9%-4.0%
3/14/2022-0.4%21.6%-2.2%
11/10/20211.6%-13.9%-14.3%
8/11/2021-5.0%15.7%21.0%
5/5/2021-9.2%-28.4%-21.5%
3/10/20213.5%14.5%12.5%
11/4/2020-5.9%-7.9%24.2%
SUMMARY STATS   
# Positive111212
# Negative121111
Median Positive3.3%8.9%22.5%
Median Negative-5.5%-6.9%-12.1%
Max Positive14.9%40.8%59.0%
Max Negative-14.1%-28.4%-41.4%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/10/202610-Q
03/31/202605/06/202610-Q
12/31/202503/30/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/13/202510-Q
12/31/202403/17/202510-K
09/30/202411/13/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202303/19/202410-K
09/30/202311/13/202310-Q
06/30/202308/14/202310-Q
03/31/202305/15/202310-Q
12/31/202203/28/202310-K
09/30/202211/09/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/10/202610-Q
03/31/202605/06/202610-Q
12/31/202503/30/202610-K
09/30/202511/12/202510-Q
06/30/202508/12/202510-Q
03/31/202505/13/202510-Q
12/31/202403/17/202510-K
09/30/202411/13/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202303/19/202410-K
09/30/202311/13/202310-Q
06/30/202308/14/202310-Q
03/31/202305/15/202310-Q
12/31/202203/28/202310-K
09/30/202211/09/202210-Q
06/30/202208/11/202210-Q
03/31/202205/04/202210-Q
12/31/202103/14/202210-K
09/30/202111/10/202110-Q
06/30/202108/11/202110-Q
03/31/202105/05/202110-Q
12/31/202003/10/202110-K
09/30/202011/04/202010-Q
06/30/202008/11/202010-Q
03/31/202005/13/202010-Q
12/31/201903/23/202010-K
09/30/201911/13/201910-Q

Recent Forward Guidance

Updated 10/4/2026

Latest: Q2 2026 Earnings Reported 8/10/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported     AffirmedGuidance: 2027 for 2027
2026 R&D ExpensesReported     AffirmedGuidance: 0 for 2026
2026 G&A ExpensesReported     AffirmedGuidance: 0 for 2026


Prior: Q1 2026 Earnings Reported 5/6/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported 2027 -0.0% LoweredGuidance: 2027.5 for 2027
2026 R&D ExpensesReported      
2026 G&A ExpensesReported      

Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported 2027.5 0 AffirmedGuidance: 2027.5 for 2027

Insider Activity

Updated 8/12/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Stahlberg, JanSee FootnoteBuy120820258.5773,099626,81775,679,855Form
2Stahlberg, JanSee FootnoteBuy120820257.8940,253317,72169,085,486Form
3Stahlberg, JanSee FootnoteBuy120820257.41208,8721,547,57464,551,840Form
4Stahlberg, JanSee FootnoteBuy120820257.41128,426951,21362,983,007Form
5Stahlberg, JanSee FootnoteBuy120820257.21240,3521,732,36160,364,313Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Stahlberg, JanSee FootnoteBuy120820258.5773,099626,81775,679,855Form
2Stahlberg, JanSee FootnoteBuy120820257.8940,253317,72169,085,486Form
3Stahlberg, JanSee FootnoteBuy120820257.41208,8721,547,57464,551,840Form
4Stahlberg, JanSee FootnoteBuy120820257.41128,426951,21362,983,007Form
5Stahlberg, JanSee FootnoteBuy120820257.21240,3521,732,36160,364,313Form
6Stahlberg, JanSee FootnoteBuy120820256.75182,8821,234,61854,916,816Form
7Stahlberg, JanSee FootnoteBuy120820256.52187,3931,221,16551,819,078Form
8Stahlberg, JanSee FootnoteBuy90420256.0050,772304,63246,586,790Form
9Stahlberg, JanSee FootnoteBuy90420256.0059,648357,88846,282,158Form
10Stahlberg, JanSee FootnoteBuy90420256.00338,2652,029,25245,916,616Form
11Stahlberg, JanSee FootnoteBuy90420255.9659,788356,57643,631,312Form
12Stahlberg, JanSee FootnoteBuy90420255.9648,172287,02843,234,103Form
13Stahlberg, JanSee FootnoteBuy90420255.8671,107416,49542,218,364Form
14Stahlberg, JanSee FootnoteBuy90420256.008,23349,39842,820,278Form
15Stahlberg, JanSee FootnoteBuy90420255.9970,414421,92142,713,852Form
16Stahlberg, JanSee FootnoteBuy90420255.91293,6011,734,91841,706,818Form

Investor Activity (13F)

Updated Oct 6, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Cooperman Leon G$13.7 Mil0.4%41Hold13F
Active Manager
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Cooperman Leon G$13.7 Mil0.4%41Hold13F
Core Cache Last Updated: 10/5/2026