Xencor (XNCR)


Market Price (9/26/2026): $23.62 | Market Cap: $1.8 BilSector: Health Care | Industry: Biotechnology

Xencor (XNCR)


Market Price (9/26/2026): $23.62
Market Cap: $1.8 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -16%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -23%, 3Y Excs Rtn is -60%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.24

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -216 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -206%

Stock price has recently run up significantly
6M Rtn6 month market price return is 108%, 12M Rtn12 month market price return is 130%

Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -29%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is 0.6%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 37%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -196%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -198%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 85%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -13%

Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 21%

Key risks
XNCR key risks include [1] a recent financial restatement due to material accounting errors and [2] an identified material weakness in its internal control over financial reporting.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -16%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -23%, 3Y Excs Rtn is -60%
3 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.24
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -216 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -206%
5 Stock price has recently run up significantly
6M Rtn6 month market price return is 108%, 12M Rtn12 month market price return is 130%
6 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -29%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is 0.6%
7 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 37%
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -196%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -198%
9 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 85%
10 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -13%
11 Significant short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 21%
12 Key risks
XNCR key risks include [1] a recent financial restatement due to material accounting errors and [2] an identified material weakness in its internal control over financial reporting.

XNCR in ETFs

Weight = XNCR's share of each fund

VTI0.00%
ITOT0.00%
IWM0.06%
IJR0.10%
XBI0.46%
VIOV0.22%
IJS0.21%
SLYV0.20%
+10 more covered ETFs

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 9/24/2026

Xencor (XNCR) stock has gained about 100% since 5/31/2026 because of the following key factors:

1. Strong Fiscal Q2 2026 Financial Results Exceeded Expectations.

Xencor reported its fiscal Q2 2026 earnings on August 5, 2026, significantly surpassing analyst estimates. The company reported an Earnings Per Share (EPS) of -$0.29, which was $0.51 better than the consensus estimate of -$0.80. Additionally, quarterly revenue increased by 17.4% year-over-year, reaching $51.22 million, substantially above the analyst forecast of $18.89 million.

2. Resolution of Ultomiris Royalty Dispute and Significant Inflow of Funds.

The company entered into a settlement agreement with Alexion Pharma International Operations regarding a commercial dispute over U.S. royalties for Ultomiris. This agreement secured Xencor a payment of $105 million, to be received in two equal installments of $52.5 million. The first payment was expected in August 2026, with $27.6 million of this royalty revenue recognized in fiscal Q2 2026 and the remaining $77.4 million anticipated for fiscal Q3 2026.

Show more
Updated on 9/24/2026

Xencor (XNCR) stock has gained about 100% since 5/31/2026 because of the following key factors:

1. Strong Fiscal Q2 2026 Financial Results Exceeded Expectations.

Xencor reported its fiscal Q2 2026 earnings on August 5, 2026, significantly surpassing analyst estimates. The company reported an Earnings Per Share (EPS) of -$0.29, which was $0.51 better than the consensus estimate of -$0.80. Additionally, quarterly revenue increased by 17.4% year-over-year, reaching $51.22 million, substantially above the analyst forecast of $18.89 million.

2. Resolution of Ultomiris Royalty Dispute and Significant Inflow of Funds.

The company entered into a settlement agreement with Alexion Pharma International Operations regarding a commercial dispute over U.S. royalties for Ultomiris. This agreement secured Xencor a payment of $105 million, to be received in two equal installments of $52.5 million. The first payment was expected in August 2026, with $27.6 million of this royalty revenue recognized in fiscal Q2 2026 and the remaining $77.4 million anticipated for fiscal Q3 2026.

3. Positive Clinical Pipeline Advancements and Upcoming Data Catalysts.

Xencor demonstrated notable progress across its clinical pipeline, particularly with its lead oncology program, XmAb819. This program, targeting clear cell renal cell carcinoma (ccRCC), reported early data showing a 25% objective response rate and 70% disease control in heavily pre-treated patients, with plans to initiate a pivotal study in 2027. Furthermore, interim Phase 2b data for XmAb942, an anti-TL1A antibody for ulcerative colitis, are expected by the end of 2026, following strong enrollment in its XENITH-UC study. The company also initiated a first-in-human study for XmAb412 in fiscal Q3 2026.

4. Upgraded Analyst Ratings and Increased Price Targets.

Following positive developments, several financial analysts revised their outlook on Xencor. As of September 2026, the stock holds a "Buy" consensus rating. Specific upgrades include Raymond James Financial raising its price target from $40.00 to $46.00 with a "strong-buy" rating on September 1, 2026, and Wedbush increasing its price objective from $26.00 to $30.00 with an "outperform" rating on August 6, 2026. Bank of America also raised its price target from $20 to $26 on September 21, 2026. The average analyst price target stands at $30.08, indicating a potential upside of 23.23% from the stock price as of September 11, 2026.

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Stock Movement Drivers

Fundamental Drivers

The 100.3% change in XNCR stock from 5/31/2026 to 9/25/2026 was primarily driven by a 87.3% change in the company's P/S Multiple.
(LTM values as of)53120269252026Change
Stock Price ($)11.8823.80100.3%
Change Contribution By: 
Total Revenues ($ Mil)971057.8%
P/S Multiple9.217.287.3%
Shares Outstanding (Mil)7576-0.8%
Cumulative Contribution100.3%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2026 to 9/25/2026
ReturnCorrelation
XNCR100.3% 
Market (SPY)2.2%5.9%
Sector (XLV)14.7%21.4%

Fundamental Drivers

The 86.4% change in XNCR stock from 2/28/2026 to 9/25/2026 was primarily driven by a 126.7% change in the company's P/S Multiple.
(LTM values as of)22820269252026Change
Stock Price ($)12.7723.8086.4%
Change Contribution By: 
Total Revenues ($ Mil)126105-16.4%
P/S Multiple7.617.2126.7%
Shares Outstanding (Mil)7576-1.7%
Cumulative Contribution86.4%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2026 to 9/25/2026
ReturnCorrelation
XNCR86.4% 
Market (SPY)13.0%22.3%
Sector (XLV)7.5%25.9%

Fundamental Drivers

The 192.7% change in XNCR stock from 8/31/2025 to 9/25/2026 was primarily driven by a 318.5% change in the company's P/S Multiple.
(LTM values as of)83120259252026Change
Stock Price ($)8.1323.80192.7%
Change Contribution By: 
Total Revenues ($ Mil)147105-28.6%
P/S Multiple4.117.2318.5%
Shares Outstanding (Mil)7476-2.1%
Cumulative Contribution192.7%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 9/25/2026
ReturnCorrelation
XNCR192.7% 
Market (SPY)20.9%23.6%
Sector (XLV)26.4%22.5%

Fundamental Drivers

The 8.3% change in XNCR stock from 8/31/2023 to 9/25/2026 was primarily driven by a 48.4% change in the company's P/S Multiple.
(LTM values as of)83120239252026Change
Stock Price ($)21.9823.808.3%
Change Contribution By: 
Total Revenues ($ Mil)113105-7.4%
P/S Multiple11.617.248.4%
Shares Outstanding (Mil)6076-21.2%
Cumulative Contribution8.3%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2023 to 9/25/2026
ReturnCorrelation
XNCR8.3% 
Market (SPY)77.8%33.9%
Sector (XLV)34.7%32.8%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
XNCR Return-8%-35%-18%8%-33%56%-45%
Peers Return-18%-32%40%-23%2%45%-10%
S&P 500 Return27%-19%24%23%16%13%105%

Monthly Win Rates [3]
XNCR Win Rate42%33%33%50%42%44% 
Peers Win Rate36%48%52%48%45%56% 
S&P 500 Win Rate75%42%67%75%67%56% 

Max Drawdowns [4]
XNCR Max Drawdown-43%-53%-55%-41%-71%-32% 
Peers Max Drawdown-43%-57%-35%-54%-47%-32% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: REGN, AMGN, ZYME, MGNX, HOWL.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 9/25/2026 (YTD)

How Low Can It Go

EventXNCRS&P 500
2025 US Tariff Shock
  % Loss-53.6%-18.8%
  % Gain to Breakeven115.4%23.1%
  Time to Breakeven187 days79 days
2024 Yen Carry Trade Unwind
  % Loss-15.8%-7.8%
  % Gain to Breakeven18.8%8.5%
  Time to Breakeven33 days18 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-30.9%-9.5%
  % Gain to Breakeven44.7%10.5%
  Time to Breakeven99 days24 days
2020 COVID-19 Crash
  % Loss-41.5%-33.7%
  % Gain to Breakeven71.0%50.9%
  Time to Breakeven126 days140 days
Q4 2018 Fed Policy Error / Growth Scare
  % Loss-15.2%-19.2%
  % Gain to Breakeven17.9%23.8%
  Time to Breakeven183 days105 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-26.4%-3.7%
  % Gain to Breakeven35.8%3.9%
  Time to Breakeven11 days6 days

Compare to REGN, AMGN, ZYME, MGNX, HOWL

In The Past

Xencor's stock fell -53.6% during the 2025 US Tariff Shock. Such a loss loss requires a 115.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventXNCRS&P 500
2025 US Tariff Shock
  % Loss-53.6%-18.8%
  % Gain to Breakeven115.4%23.1%
  Time to Breakeven187 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-30.9%-9.5%
  % Gain to Breakeven44.7%10.5%
  Time to Breakeven99 days24 days
2020 COVID-19 Crash
  % Loss-41.5%-33.7%
  % Gain to Breakeven71.0%50.9%
  Time to Breakeven126 days140 days
2016-2017 Trump Reflation Bond Selloff
  % Loss-26.4%-3.7%
  % Gain to Breakeven35.8%3.9%
  Time to Breakeven11 days6 days
2015-2016 China Devaluation / Global Growth Scare
  % Loss-47.2%-12.2%
  % Gain to Breakeven89.3%13.9%
  Time to Breakeven175 days62 days

Compare to REGN, AMGN, ZYME, MGNX, HOWL

In The Past

Xencor's stock fell -53.6% during the 2025 US Tariff Shock. Such a loss loss requires a 115.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Xencor (XNCR)

Xencor, Inc. (XNCR) is a clinical-stage biopharmaceutical company specializing in the discovery and development of engineered monoclonal antibody and cytokine therapeutics. The company's core expertise lies in designing novel protein therapeutics, primarily antibodies, to treat a range of serious medical conditions. This technology forms the foundation for both its proprietary drug candidates and products developed in collaboration with pharmaceutical partners.

The company's portfolio includes contributions to several currently marketed treatments, showcasing the success of its underlying technology. These include Sotrovimab for SARS-CoV-2, Ultomiris for specific rare blood disorders (paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome), and Monjuvi for relapsed or refractory diffuse large B-cell lymphoma. Xencor also maintains an extensive pipeline of proprietary product candidates in various stages of clinical trials, targeting conditions such as non-Hodgkin lymphoma (Plamotamab), metastatic prostate cancer (Vudalimab), neuroendocrine tumors (Tidutamab), and autoimmune diseases (XmAb564, Obexelimab). Further candidates are in development for infectious diseases like hepatitis B and influenza A, as well as neurological conditions like Alzheimer's disease.

Xencor primarily serves the global healthcare market, focusing on patients with high unmet medical needs in therapeutic areas such as oncology (various cancers), autoimmune diseases, and infectious diseases. While a clinical-stage company, its ultimate beneficiaries are patients requiring advanced biological therapies. Its business model also involves strategic partnerships with larger pharmaceutical companies, which serve as direct "customers" for licensing and co-development, bringing Xencor's innovative therapies to market.

AI Analysis | Feedback

Here are 1-2 brief analogies to describe Xencor:

  • Xencor is like a Moderna for engineered antibody drugs, developing innovative therapeutics using its proprietary platform and collaborating with larger pharma companies.
  • Xencor is like an early-stage Regeneron Pharmaceuticals, intensely focused on discovering and developing a broad pipeline of innovative antibody drugs, often leveraging partnerships for commercialization.

AI Analysis | Feedback

  • Sotrovimab: An engineered monoclonal antibody therapy targeting the SARS-CoV-2 virus.
  • Ultomiris: A treatment used for patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.
  • Monjuvi: A therapeutic drug for patients with relapsed or refractory diffuse large B-cell lymphoma.

AI Analysis | Feedback

Xencor (symbol: XNCR) primarily sells its engineered monoclonal antibody and cytokine therapeutics and associated technology to other pharmaceutical and biotechnology companies through licensing agreements and collaborations. Its revenue is largely derived from milestone payments and royalties from these partnerships. Its major customers include:
  • Vir Biotechnology, Inc. (symbol: VIR) - For products like Sotrovimab, VIR-3434, VIR-2482, and VIR-7832.
  • AstraZeneca PLC (symbol: AZN) / Alexion Pharmaceuticals - For Ultomiris.
  • MorphoSys AG (symbol: MOR) - For Monjuvi.
  • Incyte Corporation (symbol: INCY) - For Monjuvi (as a co-developer with MorphoSys).
  • Amgen Inc. (symbol: AMGN) - For product candidates such as AMG 509 and AIMab7195 (tezepelumab).
  • Novartis AG (symbol: NVS) - For product candidates described as "Novartis XmAb".
  • Bristol Myers Squibb Company (symbol: BMY) - For product candidates like BMS-986414 + BMS-986413.
  • GlaxoSmithKline PLC (symbol: GSK) - As a partner in the development and commercialization of Sotrovimab.

AI Analysis | Feedback

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Bassil I. Dahiyat, Ph.D. President & Chief Executive Officer, Director

Dr. Dahiyat is a co-founder of Xencor, established in August 1997, and has served as its President and Chief Executive Officer since February 2005, and as a board member since August 1997. He previously served as Chief Executive Officer from 1997 to 2003 and as Chief Scientific Officer from 2003 to 2005. He is also a co-inventor of Xencor's XmAb® technology. Dr. Dahiyat co-founded Xencor as a spinout of his PhD work at Caltech, and the initial funding for the company came from private family investors. He holds a Ph.D. in chemistry from Caltech and B.S. and MSE degrees in biomedical engineering from Johns Hopkins University. He currently serves on the board of directors of Kodiak Sciences Inc.

Bart Cornelissen Senior Vice President & Chief Financial Officer

Mr. Cornelissen was appointed as Senior Vice President and Chief Financial Officer of Xencor in April 2024. Before joining Xencor, he was most recently Vice President, Corporate Finance at Seagen Inc., where he was instrumental in the company's transformation and supported its $43 billion acquisition by Pfizer in 2023. Prior to Seagen, he served as Vice President, Finance for the END Fund and as finance lead for malaria and neglected tropical disease initiatives at the Bill & Melinda Gates Foundation. His earlier career included leadership roles in finance teams at DSM Nutritional Products (a former division of Roche) and global financial planning and analysis at Novartis. Mr. Cornelissen earned his M.Sc. in Business Administration from the Rotterdam School of Management at Erasmus University.

John R. Desjarlais, Ph.D. Executive Vice President, Research & Chief Scientific Officer

Dr. Desjarlais oversees all aspects of discovery and research at Xencor, including technology development, protein and antibody engineering, and the generation of drug candidates. He joined Xencor in 2001 and has held the position of Chief Scientific Officer since 2014. Before his tenure at Xencor, Dr. Desjarlais was an Assistant Professor of Chemistry at Penn State University and conducted postdoctoral research at the University of California, Berkeley. He holds a B.S. in physics from the University of Massachusetts and a Ph.D. in biophysics from Johns Hopkins University.

Celia Eckert, J.D. Senior Vice President, General Counsel & Corporate Secretary

Ms. Eckert joined Xencor in September 2019 as Vice President, General Counsel and Corporate Secretary. Her prior experience includes serving as Vice President, Corporate Legal at Synthetic Genomics, Inc., where she negotiated licensing and financial transactions. She also held positions as Associate General Counsel at Sequenom, Inc. and Senior Director, Legal Affairs at Prometheus Laboratories, Inc., where she managed patent litigation and supported commercial growth.

Dane Leone Executive Vice President & Chief Strategy Officer

Dane Leone serves as Executive Vice President & Chief Strategy Officer at Xencor.

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AI Analysis | Feedback

Here are the key risks to Xencor's business:
  1. Clinical Trial Failure and Regulatory Approval Risk: As a clinical-stage biopharmaceutical company, Xencor's business success is heavily dependent on its ability to successfully discover, develop, and commercialize drug candidates. A significant portion of its pipeline consists of product candidates in various phases of clinical trials, ranging from Phase I to Phase II/III. The drug development process is inherently lengthy, costly, and uncertain, with a high rate of failure at every stage due to issues such as lack of efficacy, adverse safety profiles, or manufacturing challenges. For example, a study indicated that only a small percentage of developmental candidates reach Phase 2, and an even smaller percentage progress to Phase 3. Any setbacks or failures in these clinical trials, or the inability to obtain necessary regulatory approvals, could significantly harm Xencor's financial condition and future prospects.
  2. Reliance on Collaborations and Partnerships: Xencor engages in numerous collaborations for the development and commercialization of several of its product candidates, including Sotrovimab, Ultomiris, Monjuvi, AMG 509, Novartis XmAb, VIR-3434, VIR-2482, VIR-7832, and BMS-986414 + BMS-986413. The success and revenue generation from these programs are significantly influenced by the continued commitment, resources, and strategic decisions of its partners. A recent example of this risk is the dispute with Alexion Pharmaceuticals regarding royalty payments for Ultomiris sales in the United States, where Alexion has indicated it does not plan to make further payments. The termination or adverse modification of these collaboration agreements, or the partners' failure to adequately perform their obligations, could materially impact Xencor's pipeline advancement, financial performance, and overall business strategy.

AI Analysis | Feedback

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Xencor (NASDAQ: XNCR) operates in significant addressable markets across its portfolio of approved products and clinical-stage candidates.

Approved Products

  • Sotrovimab (SARS-CoV-2/COVID-19): The global COVID-19 therapeutics market was valued at US$ 30.7 billion in 2021. It is projected to contract to more than US$ 16.2 billion by the end of 2031. Another estimate valued the global COVID-19 therapeutics market at approximately USD 9.36 billion in 2024.
  • Ultomiris (Paroxysmal Nocturnal Hemoglobinuria (PNH) and Atypical Hemolytic Uremic Syndrome (aHUS)):
    • Paroxysmal Nocturnal Hemoglobinuria (PNH): The global PNH treatment market size was estimated at USD 5.75 billion in 2024 and is projected to reach USD 9.96 billion by 2030. Other sources estimate the global PNH drug market size at approximately USD 4.45 billion in 2024, predicted to grow to around USD 14.76 billion by 2034.
    • Atypical Hemolytic Uremic Syndrome (aHUS): The global atypical hemolytic uremic syndrome (aHUS) treatment market was valued at US$ 1,431 million in 2023 and is expected to reach US$ 2,308.84 million by 2033. The market size in the 7MM (United States, EU4, UK, and Japan) was around USD 1,300 million in 2023.
  • Monjuvi (Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)): The global Diffuse Large B-cell Lymphoma (DLBCL) therapeutics market reached a value of USD 3,907.8 million in 2023 and is expected to reach USD 5,257.7 million by 2034. Another report valued the global DLBCL therapeutics market at USD 4.02 billion in 2024, projected to reach USD 6.36 billion by 2030. The market size in the 7MM is expected to grow from USD 5,286 million in 2025 to USD 16,562 million in 2034.

Main Product Candidates in Clinical Trials

  • Plamotamab (Non-Hodgkin Lymphoma): The global Non-Hodgkin Lymphoma therapeutics market was valued at USD 9.5 billion in 2023 and is estimated to grow to USD 17.5 billion by 2032. Another source indicates the global market size was USD 4.0 billion in 2023, expected to reach USD 7.4 billion by 2034. The global non-Hodgkin's lymphoma therapeutics market is accounted at USD 10.99 billion in 2025 and is predicted to reach approximately USD 20.94 billion by 2034.
  • Vudalimab (Metastatic Castration-Resistant Prostate Cancer (mCRPC)): The global metastatic castration-resistant prostate cancer therapeutics market size was valued at USD 21.04 billion in 2025 and is projected to grow to USD 91.85 billion by 2034. The market was valued at USD 11.1 billion in 2023 and is expected to reach USD 22.4 billion by 2032. The total mCRPC market size across the seven major markets (7MM) was estimated at nearly USD 6.8 billion in 2023.
  • Tidutamab (Neuroendocrine Tumors): The global neuroendocrine tumor treatment market was estimated at USD 2.66 billion in 2024 and is projected to grow to USD 4.89 billion by 2034. Other estimates place the global neuroendocrine tumor (NET) treatment market at USD 4.3 billion in 2024, anticipated to grow to USD 7.14 billion by 2030.
  • VIR-3434 (Hepatitis B Virus Infection): The global hepatitis B infection market is expected to reach USD 19.16 billion by 2032 from USD 12.72 billion in 2024. Another report states the global hepatitis B market is accounted at USD 4.94 billion in 2025 and predicted to increase to approximately USD 6.86 billion by 2035.
  • Xpro1595 (Alzheimer's Disease): The Alzheimer's disease market is estimated to grow from USD 11.3 billion in 2024 to reach USD 12.4 billion in 2025 and USD 29.4 billion by 2035. The Alzheimer's disease market in the 7MM is valued at approximately USD 5,048 million in 2025 and is projected to grow to USD 34,335 million in 2034.

AI Analysis | Feedback

Xencor, Inc. (XNCR) anticipates several key drivers for future revenue growth over the next two to three years, primarily stemming from the advancement of its clinical-stage pipeline and existing royalty agreements.

  1. Advancement of XmAb819 in Oncology: XmAb819, a novel T-cell engaging bispecific antibody targeting ENPP3 in clear cell renal cell carcinoma (ccRCC), is a lead oncology candidate. The company plans to present additional clinical data from its dose-expansion study in the second half of 2026 and intends to initiate a pivotal study in 2027. Positive outcomes and progression into later-stage development are expected to be significant revenue drivers through potential milestone payments and eventual commercialization.
  2. Progression of XmAb541 in Solid Tumors: XmAb541, a CLDN6 x CD3 bispecific antibody, has shown early positive responses in patients with ovarian cancer and germ cell tumors in a Phase 1 study. Xencor expects to present new clinical data in the second half of 2026 to support a recommended Phase 3 dose and plans to initiate a pivotal study in 2027. Successful advancement of this program represents another significant oncology-focused revenue opportunity.
  3. Development of XmAb942 for Autoimmune Diseases: Xencor is advancing XmAb942, a long-acting TL1A antibody, for inflammatory bowel disease, with a Phase 2b study currently underway for ulcerative colitis. Successful clinical development and potential commercialization of XmAb942 could open a new revenue stream in the autoimmune disease market. Public data disclosure for a related bispecific IL-23/P19 TL1A program is also planned for late 2026, further highlighting potential in this area.
  4. Continued Royalty Revenue from Ultomiris®: Xencor currently receives low-single digit royalties on net sales of Ultomiris (ravulizumab-cwvz) in the United States. This royalty income is based on Xencor's licensed Xtend Fc domain and is expected to continue into December 2028, providing a stable, ongoing revenue contribution.

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Capital Expenditures

  • Xencor's capital expenditures were -$3.15 million in the last 12 months (as of March 2, 2026).
  • The company's capital expenditures were -$6 million for the fiscal year ending December 31, 2024, representing a 66.95% decrease year-over-year.
  • Capital expenditures were -$18 million in 2023 and -$38 million in 2022.

Better Bets vs. Xencor (XNCR)

Peer Outperformance in Biotechnology

XNCR has outperformed 70% of its 374 Biotechnology peers over 5Y. Biotechnology ranks 10th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that XNCR has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
88%
of 467 industry peers · 130.4% return
3Y
62%
of 415 industry peers · 18.5% return
5Y
70%
of 374 industry peers · -29.8% return
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Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is XNCR's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 10.8%42.7%87.6% CAH 380% · MCK 337% · COR 165%
Managed Health Care 8 34.8%-9.4%3.1% OSCR 74% · HQY 34% · ELV 12%
Health Care Services 20 21.2%37.1%0.2% HIMS 263% · RDNT 142% · DGX 70%
Health Care Facilities 24 4.5%14.6%-0.9% NHC 275% · THC 264% · ENSG 135%
Health Care Equipment 50 -1.7%-1.1%-19.3% POCI 11475% · UFPT 375% · GKOS 205%
Health Care Supplies 12 29.6%-7.7%-38.4% LNTH 270% · HAE 52% · MMSI 21%
Pharmaceuticals 62 -8.9%7.3%-41.9% LQDA 2284% · INDV 1094% · ETON 1051%
Life Sciences Tools & Services 113 1.3%-10.1%-67.2% SNWV 1957% · NTRA 249% · MEDP 212%
Health Care Technology 21 -32.6%-53.0%-78.2% SPOK 72% · HSTM 2% · VEEV -6%
Biotechnology ← 375 -8.7%-23.0%-79.7% CELZ 1371% · DNTH 1085% · ELVN 965%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

XNCRREGNAMGNZYMEMGNXHOWLMedian
NameXencor Regenero.Amgen ZymeworksMacrogen.Werewolf. 
Mkt Price23.80788.04414.6126.523.740.9625.16
Mkt Cap1.881.0223.91.90.20.01.9
Rev LTM10515,53538,0953716821136
Op Inc LTM-2164,17411,426-155-41-31-36
FCF LTM-2083,57510,175-121-66-30-48
FCF 3Y Avg-1633,4398,754-86-99-44-65
CFO LTM-2064,68112,478-119-64-30-47
CFO 3Y Avg-1574,49810,312-83-96-44-64

Growth & Margins

XNCRREGNAMGNZYMEMGNXHOWLMedian
NameXencor Regenero.Amgen ZymeworksMacrogen.Werewolf. 
Rev Chg LTM-28.6%9.3%9.1%-69.8%11.7%-9.1%
Rev Chg 3Y Avg0.6%7.0%12.8%-19.9%68.3%-7.0%
Rev Chg Q17.5%16.7%9.5%-90.6%378.0%-16.7%
QoQ Delta Rev Chg LTM7.8%4.1%2.4%-54.3%18.3%-4.1%
Op Inc Chg LTM-49.3%6.1%39.5%-87.9%51.8%57.2%22.8%
Op Inc Chg 3Y Avg-11.7%-1.7%12.3%-73.6%1.5%-0.2%-0.9%
Op Mgn LTM-205.8%26.9%30.0%-418.8%-24.3%-148.8%-86.6%
Op Mgn 3Y Avg-136.0%28.2%24.5%-225.9%-186.8%--136.0%
QoQ Delta Op Mgn LTM12.1%1.1%1.6%-278.5%25.2%-1.6%
CFO/Rev LTM-196.1%30.1%32.8%-321.4%-38.0%-143.6%-90.8%
CFO/Rev 3Y Avg-124.6%31.2%29.3%-166.2%-153.4%--124.6%
FCF/Rev LTM-198.4%23.0%26.7%-325.1%-39.1%-143.6%-91.3%
FCF/Rev 3Y Avg-129.1%23.9%24.9%-170.6%-157.2%--129.1%

Valuation

XNCRREGNAMGNZYMEMGNXHOWLMedian
NameXencor Regenero.Amgen ZymeworksMacrogen.Werewolf. 
Mkt Cap1.881.0223.91.90.20.01.9
P/S17.25.25.952.11.42.25.5
P/Op Inc-8.419.419.6-12.5-5.8-1.5-3.7
P/EBIT-13.515.517.3-13.0-2.7-1.6-2.1
P/E-11.118.725.6-12.9-16.3-1.3-6.2
P/CFO-8.817.317.9-16.2-3.7-1.5-2.6
Total Yield-9.0%5.8%6.3%-7.7%-6.1%-74.2%-6.9%
Dividend Yield0.0%0.5%2.4%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-17.6%4.9%5.2%-8.5%-59.6%-112.0%-13.0%
D/E0.10.00.30.00.10.00.1
Net D/E-0.2-0.10.2-0.1-0.6-0.5-0.1

Returns

XNCRREGNAMGNZYMEMGNXHOWLMedian
NameXencor Regenero.Amgen ZymeworksMacrogen.Werewolf. 
1M Rtn-16.3%-3.3%-5.8%-9.5%-7.4%-2.9%-6.6%
3M Rtn58.1%24.7%16.4%9.8%-22.2%197.2%20.5%
6M Rtn108.4%7.1%20.5%9.7%27.6%22.9%21.7%
12M Rtn130.4%42.6%57.1%64.1%126.7%-52.5%60.6%
3Y Rtn18.5%-4.4%68.6%316.3%-21.6%-52.0%7.0%
1M Excs Rtn-17.2%-4.2%-6.7%-10.4%-8.3%-3.8%-7.5%
3M Excs Rtn52.8%19.4%11.1%4.5%-27.5%191.9%15.2%
6M Excs Rtn73.8%-15.1%-0.6%-12.1%-1.9%-8.3%-5.1%
12M Excs Rtn110.7%20.6%36.0%46.0%100.8%-70.4%41.0%
3Y Excs Rtn-60.1%-80.2%-8.8%223.5%-93.5%-135.2%-70.2%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Discovering and developing engineered antibody therapeutics to treat patients with cancer and126110175165 
License    81
Milestone    21
Research collaboration    93
Royalties    80
Total126110175165275


Net Income by Segment
$ Mil202520242023
Discovering and developing engineered antibody therapeutics to treat patients with cancer and-92-237-133
Total-92-237-133


Price Behavior

Price Behavior
Market Price$23.80 
Market Cap ($ Bil)1.8 
First Trading Date12/03/2013 
Distance from 52W High-18.8% 
   50 Days200 Days
DMA Price$23.59$15.68
DMA Trendupup
Distance from DMA0.9%51.8%
 3M1YR
Volatility69.7%66.6%
Downside Capture-79.8984.20
Upside Capture162.92164.51
Correlation (SPY)9.9%24.4%
XNCR Betas & Captures as of 8/31/2026

 1M2M3M6M1Y3Y
Beta-0.47-0.040.111.021.191.37
Up Beta-1.711.171.171.391.941.64
Down Beta-2.65-1.110.550.850.781.16
Up Capture281%223%169%203%255%189%
Bmk +ve Days10213268138427
Stock +ve Days14243766126350
Down Capture-379%-376%-358%17%51%108%
Bmk -ve Days11213259113324
Stock -ve Days7182760124393

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with XNCR
XNCR128.1%66.5%1.50-
Sector ETF (XLV)26.9%16.2%1.2822.8%
Equity (SPY)17.7%13.0%0.9824.2%
Gold (GLD)14.7%29.3%0.4615.4%
Commodities (DBC)46.8%20.7%1.75-11.7%
Real Estate (VNQ)4.5%13.6%0.0714.5%
Bitcoin (BTCUSD)-25.5%44.8%-0.5320.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with XNCR
XNCR-7.2%55.1%0.07-
Sector ETF (XLV)6.8%15.2%0.2635.4%
Equity (SPY)13.3%17.2%0.5936.5%
Gold (GLD)19.2%18.8%0.839.5%
Commodities (DBC)11.2%19.5%0.45-0.7%
Real Estate (VNQ)0.9%18.9%-0.0631.4%
Bitcoin (BTCUSD)12.3%52.6%0.4121.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with XNCR
XNCR-0.1%54.0%0.21-
Sector ETF (XLV)10.9%16.7%0.5340.3%
Equity (SPY)15.5%17.9%0.7340.4%
Gold (GLD)12.1%16.4%0.617.1%
Commodities (DBC)8.7%18.1%0.397.3%
Real Estate (VNQ)4.8%20.7%0.1931.4%
Bitcoin (BTCUSD)63.9%66.2%1.0412.4%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date9152026
Short Interest: Shares Quantity15.8 Mil
Short Interest: % Change Since 83120265.6%
Average Daily Volume1.2 Mil
Days-to-Cover Short Interest13.2 days
Basic Shares Quantity75.9 Mil
Short % of Basic Shares20.8%

Earnings Returns History

Updated 9/8/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/5/20260.8%16.8%34.2%
5/6/2026-5.4%-4.8%-9.5%
2/25/202613.1%6.3%2.8%
1/8/2026-5.1%-3.3%-22.3%
11/5/2025-2.6%0.1%23.0%
8/6/2025-2.3%3.1%14.2%
5/7/202510.1%1.9%20.9%
2/27/20254.2%-3.3%-20.0%
...
SUMMARY STATS   
# Positive13109
# Negative121516
Median Positive3.6%3.0%11.7%
Median Negative-4.8%-4.6%-10.1%
Max Positive13.1%16.8%34.2%
Max Negative-14.1%-13.8%-22.3%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/5/20260.8%16.8%34.2%
5/6/2026-5.4%-4.8%-9.5%
2/25/202613.1%6.3%2.8%
1/8/2026-5.1%-3.3%-22.3%
11/5/2025-2.6%0.1%23.0%
8/6/2025-2.3%3.1%14.2%
5/7/202510.1%1.9%20.9%
2/27/20254.2%-3.3%-20.0%
11/6/20242.2%4.1%11.7%
8/5/20240.4%-11.1%-6.5%
5/9/2024-4.5%-4.6%-7.0%
2/27/2024-14.1%-13.8%-15.5%
11/7/2023-7.0%-0.4%9.0%
8/3/20233.6%-0.3%-3.9%
5/8/2023-1.9%2.0%-1.3%
2/23/2023-3.1%-8.0%-18.1%
11/7/20228.8%9.6%10.1%
8/3/20220.3%2.9%-8.3%
5/5/20224.1%-3.9%-14.5%
2/23/20223.2%-1.0%-8.7%
11/8/2021-5.4%-7.8%-11.8%
8/4/20213.9%2.5%11.2%
5/5/2021-2.6%-7.0%-10.6%
2/23/20210.3%-4.8%-12.7%
11/5/2020-8.0%-1.9%-5.7%
SUMMARY STATS   
# Positive13109
# Negative121516
Median Positive3.6%3.0%11.7%
Median Negative-4.8%-4.6%-10.1%
Max Positive13.1%16.8%34.2%
Max Negative-14.1%-13.8%-22.3%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/05/202610-Q
03/31/202605/06/202610-Q
12/31/202502/25/202610-K
09/30/202511/05/202510-Q
06/30/202508/06/202510-Q
03/31/202505/07/202510-Q
12/31/202402/27/202510-K
09/30/202411/06/202410-Q
06/30/202408/05/202410-Q
03/31/202405/09/202410-Q
12/31/202302/29/202410-K
09/30/202311/08/202310-Q
06/30/202308/03/202310-Q
03/31/202305/08/202310-Q
12/31/202202/27/202310-K
09/30/202211/07/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/05/202610-Q
03/31/202605/06/202610-Q
12/31/202502/25/202610-K
09/30/202511/05/202510-Q
06/30/202508/06/202510-Q
03/31/202505/07/202510-Q
12/31/202402/27/202510-K
09/30/202411/06/202410-Q
06/30/202408/05/202410-Q
03/31/202405/09/202410-Q
12/31/202302/29/202410-K
09/30/202311/08/202310-Q
06/30/202308/03/202310-Q
03/31/202305/08/202310-Q
12/31/202202/27/202310-K
09/30/202211/07/202210-Q
06/30/202208/03/202210-Q
03/31/202205/05/202210-Q
12/31/202102/24/202210-K
09/30/202111/08/202110-Q
06/30/202108/04/202110-Q
03/31/202105/05/202110-Q
12/31/202002/24/202110-K
09/30/202011/06/202010-Q
06/30/202008/05/202010-Q
03/31/202005/08/202010-Q
12/31/201902/25/202010-K
09/30/201911/05/201910-Q

Recent Forward Guidance

Updated 8/6/2026

Latest: Q2 2026 Earnings Reported 8/5/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Cash, cash equivalents and marketable debt securitiesReported420.00 Mil430.00 Mil440.00 Mil   


Prior: Q1 2026 Earnings Reported 5/6/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2026 Cash, cash equivalents and marketable debt securitiesReported380.00 Mil390.00 Mil400.00 Mil-6.0% LoweredGuidance: 415.00 Mil for 2026

Insider Activity

Updated 7/8/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Feigal, Ellen DirectSell622202613.066,84389,370161,160Form
2Gorman, Kevin Charles DirectSell617202612.317,52792,657140,063Form
3Gustafson, Kurt A DirectSell617202612.315,47467,385181,068Form
4Ranieri, Richard J DirectSell617202612.315,47467,385168,758Form
5Montgomery, Alan Bruce DirectSell617202612.315,06462,338191,384Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Feigal, Ellen DirectSell622202613.066,84389,370161,160Form
2Gorman, Kevin Charles DirectSell617202612.317,52792,657140,063Form
3Gustafson, Kurt A DirectSell617202612.315,47467,385181,068Form
4Ranieri, Richard J DirectSell617202612.315,47467,385168,758Form
5Montgomery, Alan Bruce DirectSell617202612.315,06462,338191,384Form
6Cornelissen, Bart JanSR. VICE PRESIDENT & CFODirectSell413202612.293,49942,990932,521Form
7Eckert, CeliaSVP, GENERAL COUNSELDirectSell309202611.021,76719,472847,613Form
8Desjarlais, John RSR. VICE PRESIDENT & CSODirectSell309202611.022,50227,5712,907,338Form
9Dahiyat, Bassil IPRESIDENT & CEODirectSell309202611.026,60672,7966,020,238Form
10Eckert, CeliaSVP, GENERAL COUNSELDirectSell309202611.253,24436,480884,852Form
11Cornelissen, Bart JanSR. VICE PRESIDENT & CFODirectSell309202611.252,51728,305892,859Form
12Desjarlais, John RSR. VICE PRESIDENT & CSODirectSell309202611.254,11846,3092,995,048Form
13Dahiyat, Bassil IPRESIDENT & CEODirectSell309202611.2514,870167,2216,217,884Form
14Desjarlais, John RSR. VICE PRESIDENT & CSODirectSell304202611.902,66331,6773,217,042Form
15Eckert, CeliaSVP, GENERAL COUNSELDirectSell304202611.901,49217,747974,554Form
16Dahiyat, Bassil IPRESIDENT & CEODirectSell304202611.906,75880,3876,753,943Form
17Desjarlais, John RSR. VICE PRESIDENT & CSODirectSell1223202515.7273,3671,153,3293,718,943Form
18Dahiyat, Bassil IPRESIDENT & CEODirectSell1223202515.71114,3771,796,8637,330,836Form

Investor Activity (13F)

Updated Sep 26, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
BVF Inc/Il$86.0 Mil2.7%41Hold13F
Johnson & Johnson$9.0 Mil1.4%16Hold13F
EcoR1 Capital, LLC$26.3 Mil1.1%29TRIM -32.9%13F
Lynx1 Capital Management LP$6.5 Mil1.0%23TRIM -24.0%13F
TCG Crossover Management, LLC$29.6 Mil0.8%49Hold13F
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQAs OfFiling
Defilade Capital Management, L.P.$21.7 Mil2.9%33ExitedDec 31, 202513F
EcoR1 Capital, LLC$26.3 Mil1.1%29TRIM -32.9%Mar 31, 202613F
Lynx1 Capital Management LP$6.5 Mil1.0%23TRIM -24.0%Mar 31, 202613F
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
BVF Inc/Il$86.0 Mil2.7%41Hold13F
TCG Crossover Management, LLC$29.6 Mil0.8%49Hold13F
EcoR1 Capital, LLC$26.3 Mil1.1%29TRIM -32.9%13F
Johnson & Johnson$9.0 Mil1.4%16Hold13F
Lynx1 Capital Management LP$6.5 Mil1.0%23TRIM -24.0%13F
Core Cache Last Updated: 9/25/2026