Celldex Therapeutics (CLDX)
Market Price (5/13/2026): $32.0 | Market Cap: $2.1 BilSector: Health Care | Industry: Biotechnology
Celldex Therapeutics (CLDX)
Market Price (5/13/2026): $32.0Market Cap: $2.1 BilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -21% Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. | Weak multi-year price returns2Y Excs Rtn is -67%, 3Y Excs Rtn is -83% Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -309 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -35688% Expensive valuation multiplesP/SPrice/Sales ratio is 2,460x Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -89%, Rev Chg QQuarterly Revenue Change % is -98% Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 4091% Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -25654%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -26126% Valuation getting more expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 111% Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -18% Key risksCLDX key risks include [1] its pivotal dependency on the successful clinical trial outcomes and regulatory approval of its lead candidate, Show more. |
| Cash is significant % of market capNet D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -21% |
| Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -67%, 3Y Excs Rtn is -83% |
| Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 11% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -309 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -35688% |
| Expensive valuation multiplesP/SPrice/Sales ratio is 2,460x |
| Weak revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is -89%, Rev Chg QQuarterly Revenue Change % is -98% |
| Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 4091% |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -25654%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -26126% |
| Valuation getting more expensiveP/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 111% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -18% |
| Key risksCLDX key risks include [1] its pivotal dependency on the successful clinical trial outcomes and regulatory approval of its lead candidate, Show more. |
Qualitative Assessment
AI Analysis | Feedback
1. Early completion of Phase 3 enrollment for barzolvolimab in Chronic Spontaneous Urticaria (CSU).
Celldex announced on February 25, 2026, the completion of enrollment for its two global Phase 3 CSU studies (EMBARQ-CSU 1 and 2), six months ahead of schedule. This program enrolled 1,939 patients, marking the largest study in antihistamine-refractory CSU. This significant development drove a 24% increase in the stock price on the announcement day.
2. Positive presentations of Phase 2 clinical data for barzolvolimab across multiple indications.
Throughout February and March 2026, Celldex presented additional positive data from its Phase 2 clinical trials of barzolvolimab at major conferences, including AAAAI 2026 and AAD 2026. These presentations highlighted prolonged off-treatment efficacy in CSU, with up to 41% of patients achieving complete response seven months after their last dose, and demonstrated rapid and profound improvements in patient quality of life across chronic urticaria indications.
Show more
Stock Movement Drivers
Fundamental Drivers
The 30.1% change in CLDX stock from 1/31/2026 to 5/12/2026 was primarily driven by a 291.4% change in the company's P/S Multiple.| (LTM values as of) | 1312026 | 5122026 | Change |
|---|---|---|---|
| Stock Price ($) | 24.60 | 32.00 | 30.1% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 3 | 1 | -66.7% |
| P/S Multiple | 628.4 | 2,459.7 | 291.4% |
| Shares Outstanding (Mil) | 66 | 67 | -0.2% |
| Cumulative Contribution | 30.1% |
Market Drivers
1/31/2026 to 5/12/2026| Return | Correlation | |
|---|---|---|
| CLDX | 30.1% | |
| Market (SPY) | 3.6% | 46.7% |
| Sector (XLV) | -5.4% | 28.8% |
Fundamental Drivers
The 19.7% change in CLDX stock from 10/31/2025 to 5/12/2026 was primarily driven by a 702.6% change in the company's P/S Multiple.| (LTM values as of) | 10312025 | 5122026 | Change |
|---|---|---|---|
| Stock Price ($) | 26.73 | 32.00 | 19.7% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 6 | 1 | -85.0% |
| P/S Multiple | 306.5 | 2,459.7 | 702.6% |
| Shares Outstanding (Mil) | 66 | 67 | -0.3% |
| Cumulative Contribution | 19.7% |
Market Drivers
10/31/2025 to 5/12/2026| Return | Correlation | |
|---|---|---|
| CLDX | 19.7% | |
| Market (SPY) | 5.5% | 37.3% |
| Sector (XLV) | 2.0% | 29.4% |
Fundamental Drivers
The 53.6% change in CLDX stock from 4/30/2025 to 5/12/2026 was primarily driven by a 1149.0% change in the company's P/S Multiple.| (LTM values as of) | 4302025 | 5122026 | Change |
|---|---|---|---|
| Stock Price ($) | 20.83 | 32.00 | 53.6% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 7 | 1 | -87.7% |
| P/S Multiple | 196.9 | 2,459.7 | 1149.0% |
| Shares Outstanding (Mil) | 66 | 67 | -0.3% |
| Cumulative Contribution | 53.6% |
Market Drivers
4/30/2025 to 5/12/2026| Return | Correlation | |
|---|---|---|
| CLDX | 53.6% | |
| Market (SPY) | 30.4% | 35.9% |
| Sector (XLV) | 5.7% | 33.3% |
Fundamental Drivers
The 1.8% change in CLDX stock from 4/30/2023 to 5/12/2026 was primarily driven by a 291.2% change in the company's P/S Multiple.| (LTM values as of) | 4302023 | 5122026 | Change |
|---|---|---|---|
| Stock Price ($) | 31.44 | 32.00 | 1.8% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 2 | 1 | -63.3% |
| P/S Multiple | 628.7 | 2,459.7 | 291.2% |
| Shares Outstanding (Mil) | 47 | 67 | -29.2% |
| Cumulative Contribution | 1.8% |
Market Drivers
4/30/2023 to 5/12/2026| Return | Correlation | |
|---|---|---|
| CLDX | 1.8% | |
| Market (SPY) | 78.7% | 30.5% |
| Sector (XLV) | 14.8% | 30.7% |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| CLDX Return | 121% | 15% | -11% | -36% | 7% | 19% | 84% |
| Peers Return | -8% | 21% | -4% | 6% | 109% | 7% | 153% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 8% | 97% |
Monthly Win Rates [3] | |||||||
| CLDX Win Rate | 67% | 50% | 42% | 42% | 67% | 60% | |
| Peers Win Rate | 48% | 50% | 52% | 52% | 63% | 60% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 60% | |
Max Drawdowns [4] | |||||||
| CLDX Max Drawdown | -8% | -47% | -49% | -41% | -40% | -17% | |
| Peers Max Drawdown | -27% | -23% | -31% | -15% | -22% | -7% | |
| S&P 500 Max Drawdown | -1% | -25% | -1% | -2% | -15% | -7% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: REGN, AMGN, COGT, INCY, KNSA.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/12/2026 (YTD)
How Low Can It Go
| Event | CLDX | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -34.4% | -18.8% |
| % Gain to Breakeven | 52.3% | 23.1% |
| Time to Breakeven | 97 days | 79 days |
| 2024 Yen Carry Trade Unwind | ||
| % Loss | -12.5% | -7.8% |
| % Gain to Breakeven | 14.3% | 8.5% |
| Time to Breakeven | 16 days | 18 days |
| Summer-Fall 2023 Five Percent Yield Shock | ||
| % Loss | -38.8% | -9.5% |
| % Gain to Breakeven | 63.5% | 10.5% |
| Time to Breakeven | 49 days | 24 days |
| 2023 SVB Regional Banking Crisis | ||
| % Loss | -28.2% | -6.7% |
| % Gain to Breakeven | 39.2% | 7.1% |
| Time to Breakeven | 318 days | 31 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -47.7% | -24.5% |
| % Gain to Breakeven | 91.1% | 32.4% |
| Time to Breakeven | 183 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -30.5% | -33.7% |
| % Gain to Breakeven | 43.9% | 50.9% |
| Time to Breakeven | 32 days | 140 days |
In The Past
Celldex Therapeutics's stock fell -34.4% during the 2025 US Tariff Shock. Such a loss loss requires a 52.3% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
| Event | CLDX | S&P 500 |
|---|---|---|
| 2025 US Tariff Shock | ||
| % Loss | -34.4% | -18.8% |
| % Gain to Breakeven | 52.3% | 23.1% |
| Time to Breakeven | 97 days | 79 days |
| Summer-Fall 2023 Five Percent Yield Shock | ||
| % Loss | -38.8% | -9.5% |
| % Gain to Breakeven | 63.5% | 10.5% |
| Time to Breakeven | 49 days | 24 days |
| 2023 SVB Regional Banking Crisis | ||
| % Loss | -28.2% | -6.7% |
| % Gain to Breakeven | 39.2% | 7.1% |
| Time to Breakeven | 318 days | 31 days |
| 2022 Inflation Shock & Fed Tightening | ||
| % Loss | -47.7% | -24.5% |
| % Gain to Breakeven | 91.1% | 32.4% |
| Time to Breakeven | 183 days | 427 days |
| 2020 COVID-19 Crash | ||
| % Loss | -30.5% | -33.7% |
| % Gain to Breakeven | 43.9% | 50.9% |
| Time to Breakeven | 32 days | 140 days |
| Q4 2018 Fed Policy Error / Growth Scare | ||
| % Loss | -56.0% | -19.2% |
| % Gain to Breakeven | 127.2% | 23.7% |
| Time to Breakeven | 38 days | 105 days |
| 2011 US Debt Ceiling Crisis & European Contagion | ||
| % Loss | -42.2% | -17.9% |
| % Gain to Breakeven | 73.0% | 21.8% |
| Time to Breakeven | 106 days | 123 days |
| 2010 Eurozone Sovereign Debt Crisis / Flash Crash | ||
| % Loss | -42.6% | -15.4% |
| % Gain to Breakeven | 74.1% | 18.2% |
| Time to Breakeven | 919 days | 125 days |
In The Past
Celldex Therapeutics's stock fell -34.4% during the 2025 US Tariff Shock. Such a loss loss requires a 52.3% gain to breakeven.
Preserve Wealth
Limiting losses and compounding gains is essential to preserving wealth.
Asset Allocation
Actively managed asset allocation strategies protect wealth. Learn more.
About Celldex Therapeutics (CLDX)
AI Analysis | Feedback
Here are a few analogies for Celldex Therapeutics:
- A **startup Regeneron** focused on developing novel antibody therapies.
- An **early-stage Genentech** creating cutting-edge antibody drugs for cancer and inflammatory diseases.
AI Analysis | Feedback
```html- CDX-0159: A Phase I monoclonal antibody designed to inhibit the activity of the receptor tyrosine kinase KIT.
- CDX-1140: A human agonist monoclonal antibody that targets CD40, a key activator of the immune response.
- CDX-527: A bispecific antibody combining CD27 costimulation with PD-L1/PD-1 pathway blockade to activate anti-tumor T cell responses.
AI Analysis | Feedback
Celldex Therapeutics (CLDX) is a biopharmaceutical company primarily engaged in the research and development of therapeutic drug candidates. As a company in the clinical development stage, it does not currently have major customers for commercialized products in the traditional sense of selling drugs to patients or healthcare providers.
However, the company does engage in strategic business relationships, including research collaborations and licensing agreements, which can generate revenue or intellectual property rights from other entities. Based on the provided background, the most prominent example of such a relationship with a public company is:
- Amgen Inc. (AMGN): Celldex Therapeutics has a research collaboration and license agreement with Amgen Inc., granting Amgen exclusive rights to CDX-301 and CD40 ligand. In this context, Amgen can be considered a 'customer' for Celldex's intellectual property and drug candidates.
Other collaboration partners mentioned include the University of Southampton and Yale University, which are academic institutions rather than public companies.
AI Analysis | Feedback
nullAI Analysis | Feedback
Anthony S. Marucci - Founder, President, Chief Executive Officer and Director
Mr. Marucci was appointed President and Chief Executive Officer of Celldex in September 2008 and as a director in December 2008. He is a founder of Celldex and has held various roles with the company since May 2003, including Vice President, Chief Financial Officer, Treasurer, and Secretary. Prior to Celldex, he served as Treasurer of Medarex, Inc. (now part of Bristol-Myers Squibb Co.) from December 1998 to March 2004, and held a series of senior financial positions at Medarex from December 1998 to May 2003. Mr. Marucci was also responsible for the merger of AVANT Immunotherapeutics, Inc. with Celldex Therapeutics, Inc. in the first quarter of 2008 and the acquisition of CuraGen Corporation in the third quarter of 2009. He previously served as a member of the board of directors of Genenta Science S.p.A., a publicly held biopharmaceutical company. He received his M.B.A. from Columbia University and his M.H.L. from Brown University.
Sam Martin - Senior Vice President and Chief Financial Officer
Mr. Martin was promoted to Senior Vice President and Chief Financial Officer, effective July 1, 2017. He joined Celldex in April 2009 as Director of Financial Reporting, Planning and Analysis and most recently served as Vice President, Finance. Before joining Celldex, Mr. Martin was the Director of Finance and Corporate Compliance for Alseres Pharmaceuticals, where he was responsible for managing financial and SEC reporting and the annual budget and planning process. He began his career at Ernst & Young, completing his tenure as an Audit Manager, providing audit, review, due diligence, and consulting services to public and private companies in various industries, including biotechnology. Mr. Martin received an M.B.A. from Boston University and a B.S. from Skidmore College, and is a Certified Public Accountant.
Tibor Keler, Ph.D. - Founder, Executive Vice President and Chief Scientific Officer
Dr. Keler is a founder of Celldex and serves as the company's Executive Vice President and Chief Scientific Officer, a position he was appointed to in 2014. Previously, he was Senior Vice President of Research and Discovery at Celldex. From September 1993 to March 2004, Dr. Keler was Senior Director of Preclinical Development and Principal Scientist at Medarex (now part of Bristol-Myers Squibb Co.), where he was responsible for the preclinical development of several clinical product candidates.
Elizabeth Crowley - Senior Vice President, Chief Product Development Officer
Ms. Crowley serves as the Senior Vice President, Chief Product Development Officer at Celldex Therapeutics.
Sarah Cavanaugh - Senior Vice President, Corporate Affairs and Administration
Ms. Cavanaugh was promoted to Senior Vice President, Corporate Affairs and Administration, effective June 16, 2017. She joined Celldex in August 2012 as Vice President of Investor Relations and Corporate Communications. In her role, she is responsible for investor relations, corporate communications, human resources, employee relations, organizational development, and internal communications. Ms. Cavanaugh previously held leadership roles in organizational development and employee relations/communication. She earned her B.A. from the University of New Hampshire.
AI Analysis | Feedback
The key risks to Celldex Therapeutics (CLDX) primarily stem from its position as a clinical-stage biopharmaceutical company with drug candidates in advanced development.
-
Clinical Trial Outcomes: The most significant risk for Celldex Therapeutics is the outcome of its ongoing clinical trials, particularly for its lead drug candidate, barzolvolimab. The company's current valuation heavily relies on the successful completion of late-stage (Phase 3) trials for barzolvolimab in indications such as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). A stumble or failure in these trials could lead to a sharp decline in the stock price, as these are considered "binary results" that determine the drug's future. The company has previously experienced pipeline setbacks, such as the discontinuation of its eosinophilic esophagitis (EoE) program.
-
Cash Burn and Funding Needs: Celldex Therapeutics operates as a loss-making entity with minimal current revenue, incurring a significant "cash burn" of approximately $44 million per quarter. The company's extensive research and development, particularly for its Phase 3 programs, necessitates substantial capital. While Celldex currently possesses a cash runway expected to fund operations through 2027, persistent losses and the considerable cost associated with running multiple late-stage clinical programs without meaningful product sales pose a risk. Should the company not achieve key milestones, it may be compelled to raise additional funds through equity sales, potentially diluting existing shareholders.
-
Competition: The market for chronic urticaria, which barzolvolimab aims to address, is highly competitive. Celldex faces competition from established treatments, such as omalizumab, and other emerging oral drugs. This competitive landscape could impact barzolvolimab's potential market share and pricing power upon its potential launch, even if clinical trials are successful and regulatory approvals are secured.
AI Analysis | Feedback
nullAI Analysis | Feedback
Celldex Therapeutics (CLDX) operates in the biopharmaceutical sector, developing antibody-based therapeutics for inflammatory diseases and various forms of cancer. The addressable markets for their main product candidates are as follows:
CDX-0159 (KIT Inhibitor)
CDX-0159 targets the KIT receptor, inhibiting mast cell activity. It is being developed for mast cell-driven inflammatory diseases and certain cancers.
- Chronic Spontaneous Urticaria (CSU): The global market size for chronic spontaneous urticaria is projected to be approximately $2.66 billion in 2025, with an expected increase to $5.49 billion by 2032. In 2025, another estimate placed the global market at approximately $2.23 billion, growing to $2.41 billion in 2026, and $3.21 billion by 2030. The market in the United States was approximately $1 billion in 2024. North America was the largest regional market for chronic spontaneous urticaria in 2024.
- Prurigo Nodularis (PN): The global prurigo nodularis treatment market was valued at $2.1 billion in 2024 and is expected to reach $2.2 billion in 2025, growing to $3.1 billion by 2034. Another source estimated the global market at $2.31 billion in 2025, reaching approximately $3.29 billion by 2034. The United States market for prurigo nodularis was approximately $810 million in 2024, and is predicted to be worth around $1030 million by 2034. North America held the largest share of the global market in 2024.
- Systemic Mastocytosis (SM): The global systemic mastocytosis treatment market was valued at $310.5 million in 2023 and is projected to surpass $482.3 million by 2032. Another estimate for the global market was $1.2 billion in 2024, projected to reach $1.9 billion by 2030. The KIT inhibitors segment dominated the systemic mastocytosis treatment market in 2025. The U.S. market is expected to grow from $0.36 billion in 2024 to $0.54 billion by 2030.
- Kinase Inhibitors in Autoimmune Diseases (Global): The overall kinase inhibitor market in autoimmune diseases is projected to grow from $52.7 billion in 2025 to $89.2 billion by 2035.
CDX-1140 (CD40 Agonist)
CDX-1140 is a human agonist monoclonal antibody targeting CD40, which plays a role in activating immune responses and is expressed on various cancer cells.
- CD40 Ligand Market (Global): The CD40 ligand market, which includes applications in oncology and autoimmune diseases, grew from $776.85 million in 2025 to $816.04 million in 2026, and is expected to reach $1.13 billion by 2032.
CDX-527 (PD-L1 and CD27 Bispecific Antibody)
CDX-527 is a bispecific antibody that targets the PD-L1/PD-1 pathway and utilizes CD27 costimulation to activate anti-tumor T cell responses.
- PD-1 and PD-L1 Inhibitor Market (Global): The global PD-1 and PD-L1 inhibitor market is estimated to be $62.23 billion in 2025 and is projected to reach $204.31 billion by 2032. Another report values the global market at $57.75 billion in 2025, growing to $209.83 billion by 2033. The North American market for PD-1 and PD-L1 inhibitors is expected to be valued at around $27.56 billion by 2025.
- Bispecific Antibodies Market (Global): The global bispecific antibodies market is estimated at $9.80 billion in 2025 and is expected to reach $22.44 billion by 2030. Another projection for the global bispecific antibodies market is $17.99 billion in 2025, increasing to approximately $484.88 billion by 2034. The United States bispecific antibody market is set to grow from $11.2 billion in 2025 to approximately $448.62 billion by 2035. The cancer segment dominated the bispecific antibodies market, holding 60% of the market share in 2025.
AI Analysis | Feedback
For Celldex Therapeutics (CLDX), the following are expected drivers of future revenue growth over the next 2-3 years:
- Commercialization of Barzolvolimab (CDX-0159) for Chronic Spontaneous Urticaria (CSU): Celldex has completed enrollment in its Phase 3 CSU studies six months ahead of schedule, with topline data anticipated in Q4 2026. A Biologics License Application (BLA) submission to the U.S. FDA is planned for 2027, which, upon approval, would mark the potential market entry and a significant new revenue stream for the company.
- Expansion of Barzolvolimab into Additional Mast-Cell Mediated Diseases: Beyond CSU, Celldex is actively pursuing barzolvolimab's development for other conditions, including cold urticaria (ColdU) and symptomatic dermographism (SD), with Phase 3 studies already underway. Positive efficacy data across various medical conditions positions barzolvolimab as a potential first-in-class treatment, broadening its market potential and contributing to future revenue growth.
- Advancement of Barzolvolimab into Further Inflammatory and Allergic Conditions: The company has ongoing or planned studies for barzolvolimab in indications such as Eosinophilic Esophagitis (EoE), Prurigo Nodularis (PN), and Atopic Dermatitis (AD), with data expected in 2025 and 2026. Successful progression in these areas could significantly expand the addressable market for barzolvolimab and drive additional revenue.
- Development and Potential Commercialization of CDX-622: Celldex is progressing its bispecific antibody CDX-622, which targets stem cell factor (SCF) and thymic stromal lymphopoietin (TSLP), with healthy volunteer studies initiated and data expected in the second half of 2025. A Phase 1B study in severe asthma is planned, and positive results and further clinical advancement could lead to a new product launch and contribute to revenue growth within the forecast period.
AI Analysis | Feedback
Share Issuance
- In November 2023, Celldex Therapeutics completed an underwritten public offering of 7,425,000 shares of its common stock at $27.00 per share, generating gross proceeds of approximately $200.5 million.
- In February 2024, the company announced a proposed underwritten public offering to sell $250.0 million of its common stock, with an option for underwriters to purchase an additional $37.5 million in shares.
- The net proceeds from these offerings are intended to fund ongoing clinical and preclinical development of product candidates, including barzolvolimab, and to advance its bispecific antibody platform.
Inbound Investments
- As of December 31, 2025, institutional investors hold significant stakes, with Wellington Management Group LLP holding 8,079,608 shares valued at $219.4 million, and State Street Corp owning 3,397,713 shares valued at $92.2 million.
- Celldex Therapeutics maintains a strong cash position of $518.6 million in cash, cash equivalents, and marketable securities as of December 31, 2025, which is expected to fund operations through 2027.
Capital Expenditures
- Research and development expenses increased to $245.1 million in 2025 from $163.6 million in 2024, primarily driven by the funding of barzolvolimab Phase 3 programs and manufacturing activities.
- The company is allocating capital to support two global Phase 3 trials for barzolvolimab in Chronic Spontaneous Urticaria (EMBARQ-CSU1 and EMBARQ-CSU2) and plans to initiate a Phase 3 study for barzolvolimab in Cold Urticaria and Symptomatic Dermographism.
- Celldex is also securing contract manufacturing capacity for barzolvolimab in anticipation of its potential commercial launch.
Latest Trefis Analyses
Trade Ideas
Select ideas related to CLDX.
| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 04302026 | GEHC | GE HealthCare Technologies | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 0.0% | 0.0% | 0.0% |
| 04302026 | IQV | IQVIA | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 0.0% | 0.0% | 0.0% |
| 04302026 | UHS | Universal Health Services | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 0.0% | 0.0% | 0.0% |
| 04302026 | ABT | Abbott Laboratories | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 0.0% | 0.0% | 0.0% |
| 04302026 | ZBIO | Zenas BioPharma | Insider | Insider Buys 45DStrong Insider BuyingCompanies with multiple insider buys in the last 45 days | 0.0% | 0.0% | 0.0% |
Research & Analysis
Invest in Strategies
Wealth Management
Peer Comparisons
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 79.30 |
| Mkt Cap | 12.7 |
| Rev LTM | 3,058 |
| Op Inc LTM | 772 |
| FCF LTM | 793 |
| FCF 3Y Avg | 455 |
| CFO LTM | 841 |
| CFO 3Y Avg | 492 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 9.1% |
| Rev Chg 3Y Avg | 12.5% |
| Rev Chg Q | 19.0% |
| QoQ Delta Rev Chg LTM | 4.0% |
| Op Inc Chg LTM | 19.8% |
| Op Inc Chg 3Y Avg | 1.2% |
| Op Mgn LTM | 25.8% |
| Op Mgn 3Y Avg | 17.1% |
| QoQ Delta Op Mgn LTM | 0.9% |
| CFO/Rev LTM | 28.3% |
| CFO/Rev 3Y Avg | 19.6% |
| FCF/Rev LTM | 23.1% |
| FCF/Rev 3Y Avg | 18.0% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 12.7 |
| P/S | 5.0 |
| P/Op Inc | 15.4 |
| P/EBIT | 12.8 |
| P/E | 15.4 |
| P/CFO | 14.0 |
| Total Yield | 4.0% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | 3.6% |
| D/E | 0.0 |
| Net D/E | -0.1 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | -2.1% |
| 3M Rtn | -2.5% |
| 6M Rtn | 5.4% |
| 12M Rtn | 60.7% |
| 3Y Rtn | 55.2% |
| 1M Excs Rtn | -9.9% |
| 3M Excs Rtn | -9.1% |
| 6M Excs Rtn | 15.0% |
| 12M Excs Rtn | 40.6% |
| 3Y Excs Rtn | -26.4% |
Price Behavior
| Market Price | $32.00 | |
| Market Cap ($ Bil) | 2.1 | |
| First Trading Date | 03/26/1990 | |
| Distance from 52W High | -7.4% | |
| 50 Days | 200 Days | |
| DMA Price | $31.90 | $26.92 |
| DMA Trend | up | up |
| Distance from DMA | 0.3% | 18.9% |
| 3M | 1YR | |
| Volatility | 63.6% | 58.4% |
| Downside Capture | 0.68 | 0.81 |
| Upside Capture | 238.05 | 176.13 |
| Correlation (SPY) | 41.3% | 35.1% |
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 2.14 | 1.65 | 2.02 | 1.63 | 1.72 | 1.13 |
| Up Beta | 2.09 | 2.19 | 2.49 | 2.46 | 2.14 | 1.20 |
| Down Beta | -4.57 | 0.91 | 1.28 | 1.06 | 0.78 | 1.04 |
| Up Capture | 153% | 184% | 301% | 203% | 283% | 105% |
| Bmk +ve Days | 15 | 22 | 31 | 66 | 141 | 428 |
| Stock +ve Days | 10 | 21 | 30 | 59 | 118 | 353 |
| Down Capture | 519% | 141% | 134% | 119% | 149% | 106% |
| Bmk -ve Days | 4 | 18 | 30 | 56 | 108 | 321 |
| Stock -ve Days | 12 | 22 | 34 | 66 | 133 | 399 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CLDX | |
|---|---|---|---|---|
| CLDX | 84.4% | 59.0% | 1.26 | - |
| Sector ETF (XLV) | 11.9% | 15.5% | 0.53 | 31.2% |
| Equity (SPY) | 28.3% | 12.5% | 1.80 | 34.9% |
| Gold (GLD) | 41.3% | 26.9% | 1.26 | 1.4% |
| Commodities (DBC) | 47.5% | 18.0% | 2.10 | -8.9% |
| Real Estate (VNQ) | 12.8% | 13.5% | 0.65 | 20.2% |
| Bitcoin (BTCUSD) | -21.0% | 41.7% | -0.46 | 22.9% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CLDX | |
|---|---|---|---|---|
| CLDX | 4.0% | 59.2% | 0.30 | - |
| Sector ETF (XLV) | 5.1% | 14.6% | 0.17 | 32.9% |
| Equity (SPY) | 12.9% | 17.1% | 0.59 | 37.0% |
| Gold (GLD) | 21.0% | 17.9% | 0.95 | 1.6% |
| Commodities (DBC) | 13.4% | 19.1% | 0.57 | 3.7% |
| Real Estate (VNQ) | 3.9% | 18.8% | 0.11 | 31.8% |
| Bitcoin (BTCUSD) | 7.2% | 55.9% | 0.34 | 22.5% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CLDX | |
|---|---|---|---|---|
| CLDX | -5.8% | 78.3% | 0.28 | - |
| Sector ETF (XLV) | 9.5% | 16.5% | 0.46 | 22.0% |
| Equity (SPY) | 15.1% | 18.0% | 0.72 | 23.3% |
| Gold (GLD) | 13.4% | 15.9% | 0.70 | 1.8% |
| Commodities (DBC) | 9.7% | 17.7% | 0.46 | 6.4% |
| Real Estate (VNQ) | 5.6% | 20.7% | 0.24 | 16.1% |
| Bitcoin (BTCUSD) | 68.2% | 66.8% | 1.07 | 9.9% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Returns Analyses
Earnings Returns History
Expand for More| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 5/7/2026 | 2.0% | ||
| 2/25/2026 | -0.6% | -4.2% | 3.0% |
| 11/10/2025 | 7.5% | 14.7% | 23.2% |
| 8/7/2025 | -2.6% | 17.6% | 10.3% |
| 5/8/2025 | -6.1% | 3.0% | 6.1% |
| 2/27/2025 | 1.3% | 5.0% | -1.9% |
| 11/6/2024 | -4.2% | -2.9% | -3.1% |
| 8/8/2024 | 0.6% | 1.2% | 29.3% |
| ... | |||
| SUMMARY STATS | |||
| # Positive | 12 | 12 | 13 |
| # Negative | 9 | 8 | 7 |
| Median Positive | 6.6% | 5.5% | 13.7% |
| Median Negative | -3.6% | -3.4% | -12.7% |
| Max Positive | 27.8% | 37.4% | 51.3% |
| Max Negative | -6.1% | -12.0% | -20.7% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 03/31/2026 | 05/07/2026 | 10-Q |
| 12/31/2025 | 02/25/2026 | 10-K |
| 09/30/2025 | 11/10/2025 | 10-Q |
| 06/30/2025 | 08/07/2025 | 10-Q |
| 03/31/2025 | 05/08/2025 | 10-Q |
| 12/31/2024 | 02/27/2025 | 10-K |
| 09/30/2024 | 11/06/2024 | 10-Q |
| 06/30/2024 | 08/08/2024 | 10-Q |
| 03/31/2024 | 05/06/2024 | 10-Q |
| 12/31/2023 | 02/26/2024 | 10-K |
| 09/30/2023 | 11/02/2023 | 10-Q |
| 06/30/2023 | 08/08/2023 | 10-Q |
| 03/31/2023 | 05/04/2023 | 10-Q |
| 12/31/2022 | 02/28/2023 | 10-K |
| 09/30/2022 | 11/09/2022 | 10-Q |
| 06/30/2022 | 08/08/2022 | 10-Q |
Recent Forward Guidance [BETA]
Latest: Q1 2026 Earnings Reported 5/7/2026
| Forward Guidance | Guidance Change | ||||||
|---|---|---|---|---|---|---|---|
| Metric | Low | Mid | High | % Chg | % Delta | Change | Prior |
| Q4 2026 Topline Data Readout (CSU) | |||||||
| Q3 2026 CDX-622 Data Readout | |||||||
| 2026 Topline Data Readout (Prurigo Nodularis) | |||||||
| 2026 Topline Data Readout (Atopic Dermatitis) | |||||||
Prior: Q4 2025 Earnings Reported 2/25/2026
| Forward Guidance | Guidance Change | ||||||
|---|---|---|---|---|---|---|---|
| Metric | Low | Mid | High | % Chg | % Delta | Change | Prior |
| 2027 Cash Runway | 2,027 | 0 | Affirmed | Actual: 2,027 for 2027 | |||
Insider Activity
Expand for More| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jimenez, Freddy A | SVP & GENERAL COUNSEL | Direct | Sell | 12082025 | 29.09 | 4,166 | 121,210 | 896,010 | Form |
| 2 | Wright, Richard M | Direct | Sell | 11172025 | 24.00 | 49,298 | 1,183,177 | 500,002 | Form | |
| 3 | Jimenez, Freddy A | SVP & GENERAL COUNSEL | Direct | Sell | 8152025 | 24.77 | 771 | 19,096 | 865,929 | Form |
Industry Resources
External Quote Links
| Y Finance | Barrons |
| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |
Prefer one of these to Trefis? Tell us why.