Here are 1-3 brief analogies to describe BioAtla (BCAB):

• A Genentech for "smart" antibody cancer drugs.
• A Moderna for targeted antibody cancer therapies.
• An Amgen focused on developing safer, more precise cancer treatments.

• Conditionally Active Antibody-Drug Conjugates (CAB-ADCs): These are novel drug candidates designed to selectively deliver potent cancer therapies to tumor cells while minimizing toxicity to healthy tissues.
• BA3011: A lead CAB-ADC candidate currently in Phase 2 clinical trials for solid tumors, specifically targeting the AXL protein.
• BA3021: Another lead CAB-ADC candidate currently in Phase 2 clinical trials for solid tumors, specifically targeting the ROR2 protein.

BioAtla (BCAB) sells primarily to other companies, typically large pharmaceutical companies that collaborate on the development of their therapeutic candidates or license their technology. As a clinical-stage biotechnology company, BioAtla's revenue streams primarily come from such strategic partnerships rather than direct sales of commercialized products to individuals or healthcare providers.

Its major customer and strategic collaborator is:

• Bristol Myers Squibb Company (Symbol: BMY)

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Jay M. Short, Ph.D., Chairman, Chief Executive Officer & Cofounder

Dr. Short is the founder and CEO of BioAtla, Inc. and a co-inventor of its patented Conditionally Active Biologics (CAB) platform. He cofounded Diversa Corporation (now BASF), serving as CEO, President, and CTO from 1994 to 2005, and led what was, at the time, the largest biotechnology IPO. Earlier, he was President of Stratacyte, an antibody engineering subsidiary of Stratagene (now Agilent), and Vice President of Research & Development and Operations for Stratagene Cloning Systems. Dr. Short also founded the E. O. Wilson Biodiversity Foundation. He is an inventor on over 500 issued patents and has authored more than 100 publications.

Richard A. Waldron, Chief Financial Officer

Mr. Waldron has served as BioAtla's Senior Vice President and Chief Financial Officer since November 2013. Before joining BioAtla, he worked as an independent consultant for biotechnology, biopharmaceutical, and information technology companies. He was Chief Financial Officer of the Protein Production Division of Intrexon Corporation from 2009 to 2010. His prior experience includes serving as Vice President and Chief Financial Officer for Genelabs Technologies, Inc. (1999-2000) and GeneMedicine, Inc. (1995-1999). Mr. Waldron also held positions in investment banking, including managing director and head of finance for technology-based companies at Rauscher Pierce Refsnes, Inc. (1990-1995) and senior vice president for health care investment banking at Cowen & Company (1985-1990).

Eric Sievers, M.D., Chief Medical Officer

Dr. Sievers was appointed Chief Medical Officer of BioAtla in June 2019, bringing over 25 years of experience in clinical and translational biomedical research within the biotechnology industry, clinical practice, and academia. Before BioAtla, he was Chief Medical Officer at Trillium Therapeutics. He also spent nine years at Seattle Genetics (now Seagen), where he played a key role in the development and regulatory approval of brentuximab vedotin (Adcetris) for lymphoma. Earlier in his career, at the Fred Hutchinson Cancer Research Center and the University of Washington, he was a lead investigator for trials that led to the approval of gemtuzumab ozogamicin (Mylotarg) for acute myeloid leukemia.

BioAtla (BCAB) is a clinical-stage biopharmaceutical company focused on developing Conditionally Active Biologic (CAB) antibody therapeutics primarily for solid tumor cancers. The addressable markets for their main product candidates are as follows:

General Solid Tumor Market

• The global solid tumor therapeutics market was valued at approximately USD 207.29 billion in 2025 and is projected to reach USD 307.41 billion by 2030.
• The solid tumors market across the top 7 major markets (U.S., EU4, U.K., and Japan) reached a value of USD 183.0 billion in 2024 and is expected to reach USD 406.4 billion by 2035.
• The global solid tumor cancer treatment market size was calculated at USD 5.64 billion in 2025 and is forecasted to reach around USD 8.76 billion by 2034.
• The U.S. solid tumor cancer treatment market size was evaluated at USD 1.32 billion in 2024 and is predicted to be worth around USD 2.19 billion by 2034.

Specific Product Candidate Markets

Mecbotamab Vedotin (BA3011) - Targeting AXL-expressing solid tumors (e.g., NSCLC, Soft Tissue Sarcoma, Ovarian Cancer)

• For Non-Small Cell Lung Cancer (NSCLC):
  • The global NSCLC therapeutics market size was valued at USD 33.90 billion in 2024 and is projected to grow to USD 66.04 billion by the end of 2032. North America held a market share of 44.45% in 2024.
  • BioAtla specifically focuses on mKRAS NSCLC, which represents approximately 30% of all NSCLC patients.
  • The global metastatic lung adenocarcinoma treatment market size (a subtype of NSCLC) is expected to grow from USD 4.42 billion in 2023 to USD 12.39 billion by 2033. Another estimate projects it to reach USD 14.17 billion by 2034.
• For Soft Tissue Sarcoma:
  • The global Soft Tissue Sarcomas Treatment market size was valued at USD 1.52 billion in 2024 and is projected to reach USD 2.51 billion by 2032.
  • The global sarcoma drugs market size was estimated at USD 1,287 million (USD 1.287 billion) in 2022 and is projected to reach USD 2534.5 million (USD 2.5345 billion) by 2030.
• For Ovarian Cancer:
  • The global ovarian cancer drugs market size was estimated at USD 3.84 billion in 2024 and is expected to hit around USD 7.34 billion by 2034.
  • The U.S. ovarian cancer drugs market size is evaluated at USD 1.3 billion in 2024 and is projected to be worth around USD 2.4 billion by 2034.

Ozuriftamab Vedotin (BA3021) - Targeting ROR2-expressing solid tumors (e.g., Melanoma, Head & Neck Cancer, NSCLC, Ovarian Cancer)

• For Melanoma:
  • The global melanoma therapeutics market size was valued at USD 9.16 billion in 2024 and is projected to reach USD 21.79 billion by 2033.
  • The U.S. melanoma therapeutics market size is accounted for USD 1.92 billion in 2024 and is projected to be worth around USD 5.21 billion by 2034.
  • The melanoma market size reached a value of USD 3.9 billion in 2023 and is expected to reach USD 8.9 billion by 2034.
• For Head and Neck Cancer:
  • The global Head and Neck Cancer Therapeutics market size was valued at USD 2.18 billion in 2024 and is projected to reach USD 5.84 billion by 2033. North America is the most significant global shareholder in this market.
  • BioAtla is positioning Ozuriftamab vedotin as potentially the first approved treatment specifically for HPV+ OPSCC, with an estimated worldwide market value of approximately USD 1 billion. The potential expansion into other HPV+ solid tumors represents a market valued at over USD 7 billion worldwide.

Evalstotug (BA3071) - A CAB anti-CTLA-4 antibody (e.g., Melanoma, Renal Cell Carcinoma, Colorectal Cancer, NSCLC)

• For Colorectal Cancer:
  • The global colorectal cancer therapeutics market size was valued at USD 12.79 billion in 2024 and is expected to be worth around USD 19.95 billion by 2034.
  • The U.S. colorectal cancer therapeutics market size was estimated at USD 3.42 billion in 2024 and is predicted to be worth around USD 5.43 billion by 2034.

BA3182 - A dual CAB bispecific T-cell engager antibody (e.g., Adenocarcinomas)

• For Adenocarcinomas:
  • BA3182 has the potential to serve over one million patients globally.
  • The lung adenocarcinoma treatment market size was valued at around USD 5.1 billion in 2023 and is estimated to grow at a 10.5% CAGR from 2024 to 2032.

BioAtla (BCAB), a clinical-stage biopharmaceutical company focused on developing conditionally active biologics (CAB) for solid tumor cancers, is expected to drive future revenue growth over the next 2-3 years through a combination of strategic partnerships, milestone payments, and the advancement of its promising pipeline candidates.

1. Strategic Partnerships and Licensing Agreements: A significant driver of near-term revenue for BioAtla is its ability to secure and expand strategic partnerships and licensing agreements for its drug candidates. The company has already demonstrated this with an exclusive worldwide license agreement with Context Therapeutics Inc. for BA3362, which includes an upfront payment and potential near-term milestone payments and royalties on net sales. BioAtla has expressed confidence in closing at least one additional partnership transaction in 2025, which would further contribute to its revenue.
2. Achievement of Clinical and Regulatory Milestones: As a clinical-stage company, BioAtla's revenue will be significantly influenced by the successful progression of its pipeline through various clinical trial stages and the achievement of regulatory milestones. These achievements often trigger milestone payments from existing and future collaboration agreements. For example, the agreement with Context Therapeutics includes potential payments contingent on clinical, regulatory, and commercial milestones.
3. Advancement of Lead Antibody-Drug Conjugates (ADCs) – Mecbotamab Vedotin (Mec-V) and Ozuriftamab Vedotin (Oz-V): Continued positive clinical trial results and progression of Mecbotamab Vedotin (BA3011) and Ozuriftamab Vedotin (BA3021) are crucial. Mec-V has shown promising clinical results in sarcoma patients, extending median overall survival. Oz-V, which received FDA Fast Track Designation for recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN), has demonstrated strong efficacy in HPV+ head and neck cancer. Successful advancement of these programs could lead to further lucrative partnerships, increased milestone payments, and eventually, commercialization revenue.
4. Development of Bispecific T-cell Engagers (TCEs) – BA3182: BioAtla's bispecific T-cell engager program, particularly BA3182 (CAB-EpCAM x CAB-CD3), is another potential revenue driver. BA3182 is in Phase 1 development and has shown promising results with tumor size reductions in some patients. Positive data readouts from this program, with Phase 1 dose escalation data expected in Q2 2025 and Phase 2 expansion data expected in 1H 2026, could enhance its attractiveness for future partnerships and funding, contributing to revenue through collaboration agreements.

Share Issuance

• In December 2024, BioAtla entered into definitive agreements with institutional investors for a registered direct offering of 9,679,158 shares of common stock, each with a warrant, at a combined price of $0.9520 per share and warrant. This offering is expected to generate approximately $9.2 million in gross proceeds.
• The funds from the December 2024 offering are intended to support research and development initiatives, including advancing key clinical programs such as BA3182 and mecbotamab vedotin.

Inbound Investments

• BioAtla received a total of $25 million in payments from BeiGene under a global co-development and collaboration agreement, which was amended in December 2019 and October 2020, related to the investigational CAB CTLA-4 antibody, BA3071.
• In late 2024, BioAtla out-licensed its pre-clinical lead stage CAB-Nectin4 x CAB-CD3 TCE program, securing $15 million in upfront and near-term payments. This deal also includes potential for up to an additional $118.5 million in milestones and double-digit royalties.

Capital Expenditures

• BioAtla reported "n/a" for capital expenditures in a recent financial summary for the last 12 months, suggesting minimal or no significant capital expenditures during this period.
• The company's operational framework highlights significant research and development expenditures, with approximately $115 million for the fiscal year 2024 and $27.7 million for Q3 2024, reflecting its focus on advancing its pipeline.