Here are 1-2 brief analogies for Annexon (ANNX):

• A Regeneron focused on complement-mediated diseases.

• A Vertex Pharmaceuticals for the complement system.

• ANX005: A C1q-targeting monoclonal antibody in clinical development for autoimmune and neurodegenerative conditions such as Guillain-Barré Syndrome and Multifocal Motor Neuropathy.
• ANX007: A C1q-targeting Fab fragment in clinical development for ophthalmic diseases, specifically Geographic Atrophy.
• ANX1502: An orally available small molecule C1q inhibitor currently in preclinical development for a range of complement-mediated diseases.

Annexon (ANNX) - Major Customers

Annexon (symbol: ANNX) is a clinical-stage biopharmaceutical company focused on developing therapies for patients with complement-mediated autoimmune, neurodegenerative, and ophthalmic diseases. As a company in the research and development phase with its drug candidates in clinical trials (e.g., Phase 2 and Phase 3), Annexon does not currently have any commercialized products on the market.

Therefore, Annexon does not have "major customers" in the traditional sense of companies or individuals directly purchasing its commercial products. Its revenue primarily comes from financing activities (e.g., equity offerings) to fund its research and development.

However, if Annexon's investigational therapies successfully complete clinical development and receive regulatory approval, the ultimate beneficiaries and indirect customer categories would be individuals (patients) suffering from the specific conditions its drugs are designed to treat. The distribution and sales channels would primarily involve the healthcare system to reach these individuals. The potential categories of indirect customers or beneficiaries would include:

1. Patients with Specific Diseases: Individuals diagnosed with complement-mediated autoimmune, neurodegenerative, or ophthalmic conditions for which Annexon's therapies are developed. Examples include patients with Guillain-Barré Syndrome (GBS), amyotrophic lateral sclerosis (ALS), and geographic atrophy (GA), a form of dry age-related macular degeneration. These individuals would receive the treatments via prescription or administration by healthcare professionals.
2. Healthcare Providers: Physicians, specialists (e.g., neurologists, ophthalmologists), hospitals, and specialized clinics that would prescribe, administer, and manage the treatment of their patients with Annexon's approved therapies. These entities serve as the direct purchasers and distributors of pharmaceutical products within the healthcare system to reach the end-user patients.
3. Specialty Pharmacies: For certain complex or high-cost therapies, distribution often occurs through specialty pharmacies that provide specialized handling, patient support, and coordination of care. These pharmacies would dispense Annexon's products to eligible patients based on prescriptions from healthcare providers.

In the event of a partnership or licensing agreement for commercialization, larger pharmaceutical companies could also become key collaborators or "customers" from a business development perspective, taking on the responsibility for sales and distribution to the aforementioned categories.

• Lonza Group AG (Symbol: LONN.SW)
• IQVIA RDS Inc. (a subsidiary of IQVIA Holdings Inc.) (Symbol: IQV)
• PPD, LLC (a subsidiary of Thermo Fisher Scientific Inc.) (Symbol: TMO)
• Icon Clinical Research, LLC (a subsidiary of ICON plc) (Symbol: ICLR)

Douglas Love, President, Chief Executive Officer & Director

Douglas Love joined Annexon as President and Chief Executive Officer in December 2014. He has extensive business and legal leadership experience in biotechnology. Previously, Mr. Love served as Head of Operations for Elan Pharmaceuticals, where he led the Tysabri® multiple sclerosis franchise, contributing to nearly $2 billion in annual sales. He also spearheaded Elan's Alzheimer's Immunotherapy Program, which was licensed to Johnson & Johnson for $1 billion plus milestones and royalties. Prior to Elan, Mr. Love held roles as Corporate Counsel at Amgen, Inc., and as Section Corporate Counsel at Genentech, Inc., where he led the BioOncology Healthcare Law Group and launched several significant programs.

Jennifer Lew, Executive Vice President, Chief Financial Officer & Principal Accounting Officer

Jennifer Lew serves as the Executive Vice President, Chief Financial Officer, and Principal Accounting Officer at Annexon.

Ted Yednock, Ph.D., Executive Vice President & Chief Innovation Officer

Ted Yednock, Ph.D., is the Executive Vice President and Chief Innovation Officer at Annexon.

Jamie Dananberg, M.D., Executive Vice President & Chief Medical Officer

Jamie Dananberg, M.D., holds the position of Executive Vice President and Chief Medical Officer at Annexon.

Michael Overdorf, Executive Vice President & Chief Business Officer

Michael Overdorf is the Executive Vice President and Chief Business Officer for Annexon.

Competition from other companies developing classical complement pathway inhibitors for neurological and autoimmune diseases.

Specifically, Voyager Therapeutics, in collaboration with Neurocrine Biosciences, is developing VYT-0801 (formerly NBI-1065844), a selective C1s inhibitor. While Annexon's lead candidate ANX005 targets C1q, C1s is also a crucial enzyme in the classical complement pathway, and inhibiting it aims to achieve similar therapeutic goals of preventing classical complement activation. VYT-0801 is being investigated for neurological indications, directly overlapping with Annexon's therapeutic focus for ANX005 in diseases like Huntington's disease and ALS. The advancement of VYT-0801 or other similar agents by competitors represents a direct challenge to Annexon's potential market share and first-in-class positioning within the classical complement inhibition space for these indications.

ANX005

• Guillain-Barré Syndrome (GBS): While no specific overall market size in USD was found, ANX005 is the most advanced targeted immunotherapy in development for GBS, a disease with no FDA-approved treatments. The projected annual revenue for ANX005 in GBS is expected to reach $331 million globally by 2037.
• Huntington's Disease (HD): The global Huntington's disease treatment market was estimated at USD 457.5 million in 2023 and is projected to grow to USD 2.5 billion by 2032, with a compound annual growth rate (CAGR) of 20.8% from 2024 to 2032. The U.S. market for Huntington's disease treatment was valued at USD 167.7 million in 2023 and is projected to reach USD 894.4 million by 2032. Globally, approximately 80,000 people are affected by Huntington's disease. Another estimate indicates the global market size at USD 500 million in 2024, expected to reach USD 1,871.2 million by 2030.
• Multifocal Motor Neuropathy (MMN): Annexon is expanding its ANX005 clinical program into MMN. No specific market size in USD was identified for MMN.

ANX007 (formerly Vonaprument)

• Geographic Atrophy (GA): It is estimated that one million people in the United States and between five million and eight million people globally suffer from GA. No specific market size in USD was identified for GA.

ANX009

• Lupus Nephritis: Annexon is advancing ANX009 into a Phase 1b program for Lupus Nephritis. No specific market size in USD was identified for Lupus Nephritis.

Annexon (ANNX) is anticipated to experience significant revenue growth over the next two to three years, primarily driven by the commercialization and advancement of its late-stage clinical pipeline.

1. Launch and Commercialization of Tanruprubart (ANX005) for Guillain-Barré Syndrome (GBS): Tanruprubart, a first-in-class therapy targeting the classical complement cascade, has shown promising results in Phase 3 trials for GBS, a rare autoimmune disorder with no FDA-approved therapies. Clinical data demonstrated rapid and sustained functional recovery, with 90% of patients improving by week one and outperforming standard-of-care treatments. Annexon anticipates submitting a Biologics License Application (BLA) to the FDA in the first half of 2025 and a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) in the first quarter of 2026, positioning the drug for a potential market launch in the first half of 2026. The GBS market is estimated to reach $1.2 billion by 2030, representing a substantial revenue opportunity for Annexon.

2. Potential Approval and Commercialization of Vonaprument (ANX007) for Geographic Atrophy (GA): Vonaprument is being developed as a potential first-in-class neuroprotective treatment for geographic atrophy secondary to dry age-related macular degeneration. Enrollment for the global pivotal Phase 3 ARCHER II trial is expected to be completed in the third quarter of 2025, with topline data anticipated in the second half of 2026. Earlier Phase 2 results indicated significant preservation of vision and retinal structure. The GA market is projected to reach $2.5 billion by 2030, and the potential approval of vonaprument could significantly contribute to Annexon's revenue streams.

3. Advancement of ANX1502 for Autoimmune Indications: ANX1502 is an oral C1s inhibitor with the potential to treat a range of autoimmune diseases. The completion of its proof-of-concept (POC) trial in Cold Agglutinin Disease (CAD) is expected by mid-2025. Positive results from this trial could enable Annexon to advance ANX1502 into multiple mid-to-late-stage clinical trials for other antibody-mediated autoimmune conditions, expanding its market potential and future revenue generation. Analysts project a significant increase in Annexon's annual revenue, with forecasts for 2026 reaching an average of approximately $1.17 billion and growing further to about $12.36 billion in 2027.

Share Issuance

• Annexon completed its Initial Public Offering (IPO) in July 2020, issuing 14,750,000 shares of common stock at $17.00 per share, which generated approximately $250.8 million in gross proceeds.
• In July 2022, the company closed a private placement, raising approximately $130 million in gross proceeds from the sale of 9,013,834 shares of common stock, pre-funded warrants, and accompanying warrants.
• The number of outstanding shares significantly increased from about 16.96 million in 2020 to 75.67 million in 2023, reflecting a strategy to raise capital.

Inbound Investments

• In July 2020, Annexon secured $100 million in financing led by Redmile Group, with participation from BlackRock, Deerfield Management Company, and other investors, to advance its product candidates.
• A $130 million private placement was completed in July 2022, led by Redmile Group, LLC, and included Adage Capital Partners LP and Bain Capital Life Sciences, extending the company's operating runway into the second half of 2025.
• In September 2025, Vanguard Group Inc. acquired an additional 469,073 shares of Annexon, increasing its total holdings to 5,835,112 shares, representing 5.31% of the firm's portfolio.

Outbound Investments

• Annexon has not made any significant outbound investments or acquisitions within the last 3-5 years.

Capital Expenditures

• Capital expenditures have remained relatively low, reflecting Annexon's focus on conserving cash while advancing its pipeline.
• For the last 12 months leading up to November 2025, capital expenditures were approximately -$104,000.
• The primary focus of capital allocation is on research and development (R&D) expenses, which were $48.2 million for Q1 2025 and $44.2 million for Q2 2025, aimed at advancing lead clinical programs such as those for Guillain-Barré Syndrome (GBS), geographic atrophy (GA), and ANX1502.