Tearsheet

Repare Therapeutics (RPTX)


Market Price (1/28/2026): $2.65 | Market Cap: $113.9 Mil
Sector: Health Care | Industry: Biotechnology

Repare Therapeutics (RPTX)


Market Price (1/28/2026): $2.65
Market Cap: $113.9 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -99%
Trading close to highs
Dist 52W High is 0.0%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -79 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -667%
1 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -97%
Weak multi-year price returns
2Y Excs Rtn is -101%, 3Y Excs Rtn is -153%
Stock price has recently run up significantly
12M Rtn12 month market price return is 130%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
  Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -39%
3   Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 104%
4   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -591%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -591%
5   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -68%
6   Key risks
RPTX key risks include [1] the potential for disappointing results from its pivotal POLAR and LIONS trials, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -99%
1 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -97%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
3 Trading close to highs
Dist 52W High is 0.0%
4 Weak multi-year price returns
2Y Excs Rtn is -101%, 3Y Excs Rtn is -153%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -79 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -667%
6 Stock price has recently run up significantly
12M Rtn12 month market price return is 130%
7 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -82%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -39%
8 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 104%
9 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -591%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -591%
10 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -68%
11 Key risks
RPTX key risks include [1] the potential for disappointing results from its pivotal POLAR and LIONS trials, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

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Repare Therapeutics (RPTX) stock has gained about 50% since 9/30/2025 because of the following key factors:

1. Acquisition Agreement by XenoTherapeutics. Repare Therapeutics entered a definitive arrangement to be acquired by XenoTherapeutics, with the transaction expected to close in Q1 2026. The deal includes an estimated cash payment of $1.82 per share plus one non-transferable Contingent Value Right (CVR) per share, which entitles holders to specified percentages of future partnership and disposition proceeds. This acquisition provides a clear valuation and return to shareholders, likely driving the stock price up towards the implied acquisition value.

2. Strong Q3 2025 Financial Performance. On November 14, 2025, Repare Therapeutics reported its Q3 2025 financial results, significantly surpassing analyst expectations. The company announced earnings per share (EPS) of $0.08, considerably beating the consensus estimate of -$0.35. Additionally, quarterly revenue of $11.62 million exceeded the consensus estimate of $7.50 million, indicating strong operational performance.

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Stock Movement Drivers

Fundamental Drivers

The 50.6% change in RPTX stock from 9/30/2025 to 1/27/2026 was primarily driven by a 4648.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)93020251272026Change
Stock Price ($)1.762.6550.6%
Change Contribution By: 
Total Revenues ($ Mil)0124648.0%
P/S Multiple302.29.6-96.8%
Shares Outstanding (Mil)4343-0.1%
Cumulative Contribution50.6%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 1/27/2026
ReturnCorrelation
RPTX50.6% 
Market (SPY)4.4%-0.1%
Sector (XLV)11.7%6.6%

Fundamental Drivers

The 90.6% change in RPTX stock from 6/30/2025 to 1/27/2026 was primarily driven by a 1006.2% change in the company's Total Revenues ($ Mil).
(LTM values as of)63020251272026Change
Stock Price ($)1.392.6590.6%
Change Contribution By: 
Total Revenues ($ Mil)1121006.2%
P/S Multiple55.29.6-82.6%
Shares Outstanding (Mil)4343-0.9%
Cumulative Contribution90.6%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2025 to 1/27/2026
ReturnCorrelation
RPTX90.6% 
Market (SPY)12.9%6.1%
Sector (XLV)15.9%17.8%

Fundamental Drivers

The 102.3% change in RPTX stock from 12/31/2024 to 1/27/2026 was primarily driven by a 1047.4% change in the company's P/S Multiple.
(LTM values as of)123120241272026Change
Stock Price ($)1.312.65102.3%
Change Contribution By: 
Total Revenues ($ Mil)6712-82.2%
P/S Multiple0.89.61047.4%
Shares Outstanding (Mil)4243-1.2%
Cumulative Contribution102.3%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2024 to 1/27/2026
ReturnCorrelation
RPTX102.3% 
Market (SPY)19.7%10.7%
Sector (XLV)14.5%17.0%

Fundamental Drivers

The -82.0% change in RPTX stock from 12/31/2022 to 1/27/2026 was primarily driven by a -90.2% change in the company's Total Revenues ($ Mil).
(LTM values as of)123120221272026Change
Stock Price ($)14.712.65-82.0%
Change Contribution By: 
Total Revenues ($ Mil)12112-90.2%
P/S Multiple5.19.687.3%
Shares Outstanding (Mil)4243-2.4%
Cumulative Contribution-82.0%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2022 to 1/27/2026
ReturnCorrelation
RPTX-82.0% 
Market (SPY)88.6%18.7%
Sector (XLV)19.8%16.5%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
RPTX Return-39%-30%-50%-82%98%1%-92%
Peers Return6%-30%47%0%7%9%27%
S&P 500 Return27%-19%24%23%16%2%85%

Monthly Win Rates [3]
RPTX Win Rate33%42%42%33%67%100% 
Peers Win Rate50%48%57%45%50%20% 
S&P 500 Win Rate75%42%67%75%67%100% 

Max Drawdowns [4]
RPTX Max Drawdown-43%-60%-78%-83%-31%-3% 
Peers Max Drawdown-27%-54%-32%-24%-37%-3% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-1% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: IDYA, EXEL, ORIC, LLY, APRE.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 1/27/2026 (YTD)

How Low Can It Go

Unique KeyEventRPTXS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-92.8%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1280.7%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-34.7%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven53.1%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven54 days148 days

Compare to IDYA, EXEL, ORIC, LLY, APRE

In The Past

Repare Therapeutics's stock fell -92.8% during the 2022 Inflation Shock from a high on 1/7/2021. A -92.8% loss requires a 1280.7% gain to breakeven.

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About Repare Therapeutics (RPTX)

Repare Therapeutics Inc., a clinical-stage precision oncology company, discovers and develops therapeutics by using its synthetic lethality approach in Canada and the United States. The company uses its SNIPRx, a proprietary, genome-wide, and CRISPR-enabled platform to systematically discover and develop highly targeted cancer therapies that focuses on genomic instability, including DNA damage repair. Its lead product candidate is RP-3500, an oral small molecule inhibitor for the treatment of solid tumors with specific DNA damage repair-related genomic alterations. It is also developing RP-6306, which is under Phase I clinical trial for tumors with genetic alterations characterized by CCNE1 amplification; and Polymerase Theta program, a SL target associated with BRCA mutations and other genomic alterations. The company was incorporated in 2016 and is headquartered in Montreal, Canada.

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Moderna or BioNTech, but for discovering precision cancer medicines using a genetic screening platform.

A next-generation Blueprint Medicines or Loxo Oncology, specializing in finding cancer vulnerabilities through a unique approach called synthetic lethality.

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```html
  • RP-3500 (camonsertib): An ATR inhibitor in clinical development for the treatment of solid tumors with specific genetic alterations such as ATM mutations.
  • RP-6306: A PKMYT1 inhibitor being investigated for its potential to treat solid tumors with specific genetic alterations like CCNE1 amplification.
  • Lunresertib (RP-9036): A Polθ inhibitor in partnership with Roche, currently in Phase 1 clinical trials for advanced solid tumors.
```

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Repare Therapeutics (RPTX) is a clinical-stage precision oncology company focused on developing novel synthetic lethality medicines. As such, it sells primarily to other companies rather than individuals. Its revenue is primarily derived from collaboration and license agreements with larger pharmaceutical companies. The major customer companies of Repare Therapeutics are: * **F. Hoffmann-La Roche Ltd** (SIX: ROG, OTCQX: RHHBY) – Repare has a significant collaboration agreement with Roche (and its subsidiary Genentech) for the development and commercialization of ATR inhibitors. * **Bristol Myers Squibb Company** (NYSE: BMY) – Repare has a collaboration agreement with Bristol Myers Squibb for the discovery, development, and commercialization of precision oncology medicines.

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Steve Forte, President, Chief Executive Officer & Chief Financial Officer

Mr. Forte was appointed President, CEO, and CFO of Repare Therapeutics in April 2025, having previously served as Executive Vice President and CFO since October 2019. Prior to joining Repare, he served as Chief Financial Officer of Clementia Pharmaceuticals Inc., which was acquired by Ipsen S.A. for $1.3 billion. He also previously served as Chief Financial Officer of Thinking Capital Financial Corporation, a Canadian financial technology firm, where he ultimately led the firm through a sale to Purpose Investments. Mr. Forte held various financial leadership roles at Aptalis Pharma Inc. and CST Canada Co. from 2005 to 2015.

Michael Zinda, Ph.D., Executive Vice President & Chief Scientific Officer

Dr. Zinda serves as the Executive Vice President and Chief Scientific Officer at Repare Therapeutics. His prior experience includes serving as executive director of Cancer Biosciences at AstraZeneca.

Maria Koehler, M.D., Ph.D., Executive Vice President & Chief Medical Officer

Dr. Koehler is the Executive Vice President and Chief Medical Officer at Repare Therapeutics. Her previous roles include serving as Chief Medical Officer of Bicycle Therapeutics and Vice President of Strategy for Pfizer Oncology.

Daniel Bélanger, Executive Vice President, Human Resources

Mr. Bélanger joined Repare Therapeutics as Executive Vice President, Human Resources in May 2023. He brings 25 years of global Human Resources experience within the life science industry, having previously served as Chief Human Resources Officer at another company and held progressive global leadership roles in Human Resources for 17 years at Aptalis Pharma, formerly Axcan Pharma.

Sandra Alves, Chief Accounting Officer

Ms. Alves has been promoted to Chief Accounting Officer at Repare Therapeutics. Prior to this role, she served as Vice President and Corporate Controller at the company.

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The key risks to Repare Therapeutics (RPTX) are primarily associated with the inherent challenges of a clinical-stage biotechnology company, its financial sustainability, and broader market dynamics.

  1. Clinical Trial Outcomes and Regulatory Approval: As a clinical-stage oncology company, Repare Therapeutics' success hinges on the outcomes of its ongoing and future clinical trials. There is a significant risk that positive results observed in preclinical testing and earlier clinical trials may not be replicated in later-stage trials, or that the data generated may not be sufficient to demonstrate the efficacy and safety of a product candidate to regulatory authorities. Disappointing results from pivotal trials, such as POLAR and LIONS, could significantly impact the company's prospects. The uncertainties and timing associated with the regulatory approval process also pose a substantial risk.
  2. Need for Additional Funding: Repare Therapeutics requires substantial additional capital to finance its operations and advance its pipeline. While the company benefits from collaboration and licensing agreements, and potential milestone payments can provide non-dilutive funding, the sustainability and realization of these revenues are not guaranteed. A potential increase in research and development (R&D) and operational expenses could necessitate raising capital through equity markets sooner than anticipated, potentially leading to dilution for existing shareholders. The company recently undertook a significant workforce reduction of approximately 75% to extend its cash runway, indicating existing financial pressures.
  3. Competition and Macroeconomic Conditions: Repare Therapeutics operates in a highly competitive biopharmaceutical landscape, facing risks from changes in expected or existing competition. Furthermore, broader macroeconomic conditions, including fluctuations in inflation, uncertain credit and financial markets, and geopolitical events (such as conflicts in Ukraine and the Middle East), can adversely impact the company's business, its ability to conduct clinical trials, and its overall financial position.

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Repare Therapeutics (symbol: RPTX) is a clinical-stage precision oncology company with several main product candidates in its pipeline.

For their product candidates, the addressable markets are identified as follows:

  • Lunresertib (RP-6306): This is a PKMYT1 inhibitor. The global PKMYT1 inhibitors market was valued at USD 90.2 million in 2024 and is projected to grow to USD 1.1 billion by 2035, with a Compound Annual Growth Rate (CAGR) of 25.7% from 2025 to 2030.
  • Camonsertib (RP-3500): This is an ATR inhibitor. The global ATR Kinase Inhibitor market size reached USD 1.24 billion in 2024 and is expected to grow to USD 5.13 billion by 2033, expanding at a CAGR of 17.8% from 2025 to 2033.
  • RP-1664: This is a PLK4 inhibitor designed to target TRIM37-high solid tumors, including neuroblastoma and breast cancer. A specific addressable market size for "TRIM37-high solid tumors" or for PLK4 inhibitors in monetary terms could not be identified.
  • RP-3467: This is a Polθ ATPase inhibitor associated with BRCA mutations and other genomic alterations, targeting molecularly selected advanced solid tumors such as ovarian, breast, metastatic castration-resistant prostate, and pancreatic adenocarcinoma. The global BRCA Mutations Treatment Market was valued at approximately USD 4.37 billion in 2023 and is projected to reach USD 4.88 billion in 2024. The global BRCA Mutation-Positive Ovarian Cancer Market was valued at USD 1874.78 million in 2024 and is expected to increase to USD 3607.17 million by 2031, growing at a CAGR of 9.8%. North America accounts for over 38% of this global market. Additionally, the global market for Breast Cancer 1 (BRCA1) and Breast Cancer 2 (BRCA2) Genes, which RP-3467 targets, was USD 5.62 billion in 2022 and is expected to reach USD 11.28 billion by 2030, with a CAGR of 9.10% during the forecast period from 2023 to 2030.

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Repare Therapeutics (RPTX) is a clinical-stage precision oncology company, and its future revenue growth over the next 2-3 years is expected to be primarily driven by its strategic collaborations and the advancement of its pipeline programs. Here are 3-5 expected drivers of future revenue growth:
  • Milestone Payments and Royalties from Licensing Agreements: Repare Therapeutics generates revenue through collaboration and license agreements with larger pharmaceutical partners, receiving upfront payments, milestone payments tied to research, development, and regulatory progress, and potential future royalties on product sales. A significant driver will be the exclusive worldwide licensing agreement with Debiopharm for lunresertib (a first-in-class PKMYT1 inhibitor), signed in July 2025. This agreement includes a $10 million upfront payment and eligibility for up to $257 million in potential clinical, regulatory, commercial, and sales milestones, as well as single-digit royalties on global net sales.
  • Advancement and Potential Commercialization of Clinical Pipeline (RP-1664 and RP-3467): The company has reprioritized its clinical portfolio to focus on advancing three ongoing Phase 1 clinical trials: RP-1664 (LIONS trial, a PLK4 inhibitor) and RP-3467 (POLAR trial, a Polθ ATPase inhibitor), and lunresertib in combination with Debiopharm's WEE1 inhibitor, Debio 0123. Initial data readouts for the LIONS and POLAR trials are expected in the fourth quarter of 2025. Positive clinical trial results for these candidates could trigger further milestone payments from existing or new partnerships and pave the way for future commercialization, thereby contributing to revenue growth.
  • New Strategic Partnerships and Out-licensing Opportunities: Repare is actively exploring strategic alternatives and partnerships across its portfolio to enhance long-term shareholder value. This includes seeking partnering opportunities for programs like the lunresertib and camonsertib combination. Any new collaboration agreements for its innovative pipeline assets, particularly those utilizing its proprietary SNIPRx® platform, could lead to additional upfront payments and milestone revenues.

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Share Issuance

  • Repare Therapeutics had significant capital stock issuances of $247.84 million in 2020 and $95.56 million in 2021, likely associated with its initial public offering in 2020.
  • Smaller capital stock issuances were reported at $0.88 million in 2022, $0.84 million in 2023, and $0.54 million in 2025.
  • The number of shares outstanding increased by 0.92% year-over-year as of October 28, 2025.

Inbound Investments

  • The company entered into an exclusive worldwide licensing agreement with Debiopharm for lunresertib, receiving a $10 million upfront payment and up to $257 million in potential milestone payments and royalties.
  • Repare Therapeutics out-licensed discovery platforms to DCx Biotherapeutics, which included a $1 million upfront payment, $3 million in near-term payments, 9.99% equity, anti-dilution rights, and future milestones.
  • A collaboration with Bristol Myers Squibb was established (mentioned in 2020 filings) to leverage Repare's SNIPRx platform for the discovery and development of oncology medicines.

Capital Expenditures

  • Capital expenditures were reported as $0 in the last 12 months (prior to late 2024/early 2025), indicating minimal spending on long-term assets during this period.
  • The company's primary focus for capital allocation is on advancing its clinical-stage precision oncology pipeline, which includes candidates like lunresertib, camonsertib, RP-1664, and RP-3467.

Better Bets vs. Repare Therapeutics (RPTX)

Latest Trefis Analyses

TitleDate
0DASHBOARDS 
1How Low Can Repare Therapeutics Stock Really Go?10/17/2025
Title
0ARTICLES

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Unique Key

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

RPTXIDYAEXELORICLLYAPREMedian
NameRepare T.IDEAYA B.Exelixis ORIC Pha.Eli LillyAprea Th. 
Mkt Price2.6534.7443.7412.111,039.510.8323.43
Mkt Cap0.13.111.71.2933.40.02.1
Rev LTM122152,288053,2580113
Op Inc LTM-79-209820-14822,882-14-47
FCF LTM-70-105744-117-50-13-60
FCF 3Y Avg-93-125428-102-156-13-97
CFO LTM-70-102791-11710,938-13-42
CFO 3Y Avg-92-122553-1017,230-13-53

Growth & Margins

RPTXIDYAEXELORICLLYAPREMedian
NameRepare T.IDEAYA B.Exelixis ORIC Pha.Eli LillyAprea Th. 
Rev Chg LTM-82.2%5,377.7%9.9%-36.8%-23.4%
Rev Chg 3Y Avg-39.1%1,747.2%11.8%-23.4%-17.6%
Rev Chg Q--10.8%-37.6%-24.2%
QoQ Delta Rev Chg LTM4,648.0%2,969.1%2.6%-8.7%-1,488.9%
Op Mgn LTM-667.3%-97.2%35.8%-43.0%--30.7%
Op Mgn 3Y Avg-330.8%-2,111.5%22.5%-35.6%--154.2%
QoQ Delta Op Mgn LTM44,782.7%5,391.7%2.1%-1.8%-2,696.9%
CFO/Rev LTM-591.0%-47.6%34.6%-20.5%--13.5%
CFO/Rev 3Y Avg-311.9%-1,451.0%26.5%-17.8%--147.1%
FCF/Rev LTM-591.0%-49.1%32.5%--0.1%--24.6%
FCF/Rev 3Y Avg-313.0%-1,484.2%19.8%-0.5%--156.3%

Valuation

RPTXIDYAEXELORICLLYAPREMedian
NameRepare T.IDEAYA B.Exelixis ORIC Pha.Eli LillyAprea Th. 
Mkt Cap0.13.111.71.2933.40.02.1
P/S9.614.35.1-17.5-12.0
P/EBIT-1.4-14.714.3-8.152.5-0.4-0.9
P/E-1.6-19.217.3-8.967.6-0.4-1.0
P/CFO-1.6-30.114.8-10.385.3-0.4-1.0
Total Yield-63.4%-5.2%5.8%-11.3%2.0%-246.5%-8.2%
Dividend Yield0.0%0.0%0.0%0.0%0.5%0.0%0.0%
FCF Yield 3Y Avg-81.6%-5.3%4.1%-16.2%0.0%-129.6%-10.7%
D/E0.00.00.00.00.00.00.0
Net D/E-1.0-0.2-0.1-0.20.0-2.6-0.2

Returns

RPTXIDYAEXELORICLLYAPREMedian
NameRepare T.IDEAYA B.Exelixis ORIC Pha.Eli LillyAprea Th. 
1M Rtn3.1%-1.3%-5.4%46.8%-3.5%-15.4%-2.4%
3M Rtn48.0%4.7%9.1%-9.8%26.9%-41.6%6.9%
6M Rtn73.2%39.9%18.4%9.7%36.7%-52.9%27.6%
12M Rtn130.4%46.0%33.6%11.8%29.6%-77.9%31.6%
3Y Rtn-78.7%105.8%150.4%97.6%211.2%-91.3%101.7%
1M Excs Rtn3.3%-3.3%-6.6%43.0%-4.2%-13.5%-3.7%
3M Excs Rtn32.5%16.3%10.2%-10.3%23.4%-43.5%13.3%
6M Excs Rtn58.5%29.6%-10.7%-0.9%19.9%-65.2%9.5%
12M Excs Rtn102.8%32.7%20.7%2.9%19.0%-94.6%19.8%
3Y Excs Rtn-153.2%21.4%85.8%5.6%131.9%-167.2%13.5%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Research, development and eventual commercialization of precision oncology drugs targeting specific 1328  
Total 1328  


Assets by Segment
$ Mil20242023202220212020
Research, development and eventual commercialization of precision oncology drugs targeting specific254  357103
Total254  357103


Price Behavior

Price Behavior
Market Price$2.65 
Market Cap ($ Bil)0.1 
First Trading Date06/19/2020 
Distance from 52W High0.0% 
   50 Days200 Days
DMA Price$2.33$1.74
DMA Trendupup
Distance from DMA13.8%52.0%
 3M1YR
Volatility78.7%60.1%
Downside Capture-104.1017.70
Upside Capture128.6399.64
Correlation (SPY)-2.7%12.2%
RPTX Betas & Captures as of 12/31/2025

 1M2M3M6M1Y3Y
Beta1.52-0.29-0.000.370.340.97
Up Beta-3.660.03-0.31-0.39-0.030.25
Down Beta1.59-0.410.16-0.130.740.98
Up Capture436%148%124%189%73%89%
Bmk +ve Days11233772143431
Stock +ve Days10172965112328
Down Capture13%-168%-96%9%15%111%
Bmk -ve Days11182755108320
Stock -ve Days11202952106379

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RPTX
RPTX121.0%60.4%1.53-
Sector ETF (XLV)9.2%17.3%0.3518.7%
Equity (SPY)15.5%19.3%0.6212.0%
Gold (GLD)87.8%20.6%2.984.3%
Commodities (DBC)10.6%15.5%0.456.9%
Real Estate (VNQ)3.6%16.5%0.0420.7%
Bitcoin (BTCUSD)-15.6%39.7%-0.3314.6%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RPTX
RPTX-41.7%75.6%-0.36-
Sector ETF (XLV)7.2%14.5%0.3222.1%
Equity (SPY)14.1%17.1%0.6626.3%
Gold (GLD)22.3%15.7%1.146.3%
Commodities (DBC)12.3%18.7%0.534.2%
Real Estate (VNQ)4.8%18.8%0.1624.1%
Bitcoin (BTCUSD)20.0%57.9%0.5512.5%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with RPTX
RPTX-21.7%75.0%-0.24-
Sector ETF (XLV)10.6%16.6%0.5322.0%
Equity (SPY)15.8%17.9%0.7625.5%
Gold (GLD)16.5%14.9%0.926.9%
Commodities (DBC)8.9%17.6%0.424.1%
Real Estate (VNQ)5.9%20.8%0.2522.9%
Bitcoin (BTCUSD)72.5%66.5%1.1113.0%

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Short Interest

Short Interest: As Of Date1152026
Short Interest: Shares Quantity0.4 Mil
Short Interest: % Change Since 12312025125.3%
Average Daily Volume1.0 Mil
Days-to-Cover Short Interest1
Basic Shares Quantity43.0 Mil
Short % of Basic Shares1.0%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/14/202532.1%27.9%32.7%
8/8/20251.0%2.6%12.5%
3/3/2025-1.7%0.4%-16.4%
11/7/2024-3.3%-9.7%-12.7%
8/6/2024-8.0%-8.4%-14.9%
2/28/2024-0.9%-1.1%-29.9%
11/9/2023-10.8%28.7%54.5%
8/9/202317.1%13.2%24.7%
...
SUMMARY STATS   
# Positive101210
# Negative979
Median Positive3.0%6.6%20.5%
Median Negative-1.7%-8.4%-12.7%
Max Positive32.1%28.7%54.5%
Max Negative-10.8%-14.3%-29.9%

SEC Filings

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Report DateFiling DateFiling
09/30/202511/14/202510-Q
06/30/202508/08/202510-Q
03/31/202505/13/202510-Q
12/31/202403/03/202510-K
09/30/202411/07/202410-Q
06/30/202408/06/202410-Q
03/31/202405/07/202410-Q
12/31/202302/28/202410-K
09/30/202311/09/202310-Q
06/30/202308/09/202310-Q
03/31/202305/09/202310-Q
12/31/202202/28/202310-K
09/30/202211/09/202210-Q
06/30/202208/04/202210-Q
03/31/202205/05/202210-Q
12/31/202103/01/202210-K

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Koehler, MariaEVP, CHIEF MEDICAL OFFICERDirectSell31420251.143,5964,099259,707Form
2Zinda, MichaelEVP, CHIEF SCIENTIFIC OFFICERDirectSell31420251.145,6116,39791,539Form
3Forte, SteveEVP, CHIEF FINANCIAL OFFICERDirectSell31420251.146,8847,84862,456Form
4Segal, Lloyd MitchellPRESIDENT AND CEODirectSell31420251.1421,17924,144141,809Form