Tearsheet

Relmada Therapeutics (RLMD)


Market Price (12/28/2025): $4.71 | Market Cap: $156.3 Mil
Sector: Health Care | Industry: Biotechnology

Relmada Therapeutics (RLMD)


Market Price (12/28/2025): $4.71
Market Cap: $156.3 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.


0 Megatrend and thematic drivers
Megatrends include Neurological & Psychiatric Health, and Precision Medicine. Themes include Depression & Mood Disorder Therapies, CNS Drug Development, Show more.
Trading close to highs
Dist 52W High is -2.0%
Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
1  Weak multi-year price returns
3Y Excs Rtn is -40%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -58 Mil
2   Stock price has recently run up significantly
6M Rtn6 month market price return is 639%, 12M Rtn12 month market price return is 1078%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -42%
4   High stock price volatility
Vol 12M is 153%
5   Key risks
RLMD key risks include [1] repeated Phase 3 clinical trial failures of its lead candidate, Show more.
0 Megatrend and thematic drivers
Megatrends include Neurological & Psychiatric Health, and Precision Medicine. Themes include Depression & Mood Disorder Therapies, CNS Drug Development, Show more.
1 Trading close to highs
Dist 52W High is -2.0%
2 Weak multi-year price returns
3Y Excs Rtn is -40%
3 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -58 Mil
5 Stock price has recently run up significantly
6M Rtn6 month market price return is 639%, 12M Rtn12 month market price return is 1078%
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -42%
7 High stock price volatility
Vol 12M is 153%
8 Key risks
RLMD key risks include [1] repeated Phase 3 clinical trial failures of its lead candidate, Show more.

Valuation, Metrics & Events

RLMD Stock


Why The Stock Moved


Qualitative Assessment

AI Analysis | Feedback

Relmada Therapeutics (RLMD) has experienced significant stock movement, and key factors contributing to a substantial increase, such as the 303% mentioned, include promising clinical trial data and strategic corporate developments.

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<b>1. Positive Phase 2 Data for NDV-01:</b> The company reported highly promising initial proof-of-concept Phase 2 data for NDV-01, its bladder cancer treatment. This included an overall response rate of 90% and a complete response rate of 100% in carcinoma in situ patients.

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<b>2. Favorable FDA Feedback for NDV-01:</b> Relmada received encouraging feedback from the FDA, supporting two distinct and acceptable registrational study paths for NDV-01 in non-muscle invasive bladder cancer. This guidance helps de-risk the regulatory pathway for the drug.

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<b>3. Advancement of Sepranolone Program:</b> The company is progressing its novel neurosteroid, sepranolone, towards a Phase 2b study for Tourette syndrome and is also evaluating it for other compulsion-related disorders. Initial Phase 2 data for sepranolone has been encouraging.

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<b>4. Strategic Financial Management and Corporate Updates:</b> Despite increased operational cash usage, Relmada reported a decrease in net loss and maintained a cash balance that management believes is sufficient to support operations through crucial milestones.

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<b>5. Successful Underwritten Offering:</b> Relmada Therapeutics completed a $100 million underwritten offering of common stock and pre-funded warrants. This influx of capital can be seen as a sign of investor confidence and provides funding for ongoing and future development programs.

Show more

Stock Movement Drivers

Fundamental Drivers

The 149.2% change in RLMD stock from 9/27/2025 to 12/27/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
927202512272025Change
Stock Price ($)1.814.51149.17%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)33.1933.190.00%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

9/27/2025 to 12/27/2025
ReturnCorrelation
RLMD149.2% 
Market (SPY)4.3%17.0%
Sector (XLV)15.2%26.4%

Fundamental Drivers

The 639.3% change in RLMD stock from 6/28/2025 to 12/27/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
628202512272025Change
Stock Price ($)0.614.51639.34%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)30.4133.19-9.15%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

6/28/2025 to 12/27/2025
ReturnCorrelation
RLMD639.3% 
Market (SPY)12.6%8.3%
Sector (XLV)17.0%20.2%

Fundamental Drivers

The 1077.5% change in RLMD stock from 12/27/2024 to 12/27/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
1227202412272025Change
Stock Price ($)0.384.511077.55%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)30.1733.19-10.00%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

12/27/2024 to 12/27/2025
ReturnCorrelation
RLMD1077.5% 
Market (SPY)17.0%10.2%
Sector (XLV)13.8%8.1%

Fundamental Drivers

The 40.9% change in RLMD stock from 12/28/2022 to 12/27/2025 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
1228202212272025Change
Stock Price ($)3.204.5140.94%
Change Contribution ByLTMLTM
Total Revenues ($ Mil)0.000.00�
P/S Multiple∞∞�
Shares Outstanding (Mil)30.0633.19-10.40%
Cumulative Contribution�

LTM = Last Twelve Months as of date shown

Market Drivers

12/28/2023 to 12/27/2025
ReturnCorrelation
RLMD19.0% 
Market (SPY)48.0%6.8%
Sector (XLV)17.9%7.4%

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
RLMD Return-18%-30%-85%19%-87%785%-88%
Peers Return16%38%-12%21%26%16%150%
S&P 500 Return16%27%-19%24%23%18%114%

Monthly Win Rates [3]
RLMD Win Rate50%50%50%50%33%75% 
Peers Win Rate52%65%42%68%57%52% 
S&P 500 Win Rate58%75%42%67%75%73% 

Max Drawdowns [4]
RLMD Max Drawdown-39%-47%-90%-36%-91%-52% 
Peers Max Drawdown-34%-5%-26%-7%-9%-23% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: HPQ, HPE, IBM, CSCO, AAPL.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/26/2025 (YTD)

How Low Can It Go

Unique KeyEventRLMDS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-94.5%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1710.1%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-52.6%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven110.8%51.3%
2020 Covid PandemicTime to BreakevenTime to BreakevenNot Fully Recovered days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-37.5%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven60.1%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven49 days120 days

Compare to HPQ, HPE, IBM, CSCO, AAPL

In The Past

Relmada Therapeutics's stock fell -94.5% during the 2022 Inflation Shock from a high on 1/12/2021. A -94.5% loss requires a 1710.1% gain to breakeven.

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About Relmada Therapeutics (RLMD)

Relmada Therapeutics, Inc., a clinical-stage biotechnology company, focuses on developing various products for the treatment of central nervous system (CNS) diseases and other disorders. Its lead product candidate is Esmethadone (d-methadone, dextromethadone, and REL-1017), a new chemical entity and N-methyl-D-aspartate receptor antagonist that is in Phase 3 clinical trials for the adjunctive or monotherapy treatment of major depressive disorder in adults. The company was founded in 2004 and is headquartered in Coral Gables, Florida.

AI Analysis | Feedback

Here are 1-3 brief analogies for Relmada Therapeutics (RLMD):

  • Relmada Therapeutics is a clinical-stage biotech company with its future largely depending on one promising drug for depression, similar to how Moderna was before its vaccine breakthrough.
  • Relmada Therapeutics is a small biotech aiming to be a leader in CNS disorders, similar to a nascent Biogen (known for neurology drugs) but with its current focus entirely on one depression treatment.
  • Relmada Therapeutics is a speculative biotech company where its future rests on one breakthrough drug for depression, much like an early-stage Vertex Pharmaceuticals betting its future on its cystic fibrosis treatments.

AI Analysis | Feedback

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  • REL-1017 (esmethadone): An investigational NMDA receptor modulator being developed as an adjunctive treatment for major depressive disorder (MDD).
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AI Analysis | Feedback

Relmada Therapeutics (RLMD) is a clinical-stage biopharmaceutical company focused on the development of novel therapies for central nervous system (CNS) disorders. As of the current date, the company does not have any commercialized products available for sale on the market. Therefore, Relmada Therapeutics does not have "major customers" in the traditional sense of companies or individuals purchasing its products. Its primary activities are research and development, including conducting clinical trials for its lead product candidate, REL-1017, for the treatment of Major Depressive Disorder (MDD). The company's funding primarily comes from financing activities, such as equity offerings and potential strategic partnerships or licensing agreements with larger pharmaceutical companies, rather than from product sales. If Relmada Therapeutics were to successfully commercialize a product in the future, its customers would primarily be:
  • Pharmaceutical Wholesalers/Distributors: Companies like McKesson (MCK), AmerisourceBergen (ABC), and Cardinal Health (CAH) would purchase the product for distribution to pharmacies and healthcare providers.
  • Hospitals and Healthcare Systems: Major healthcare networks and hospitals would purchase the drug for use within their facilities.
  • Retail and Specialty Pharmacies: Pharmacies would stock and dispense the medication to patients based on prescriptions.

AI Analysis | Feedback

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Sergio Traversa, Pharm.D., MBA, Chief Executive Officer

Dr. Traversa has served as Relmada Therapeutics' Chief Executive Officer since April 2012. He was the co-founder and CEO of Medeor Inc., a pharmaceutical company spun off from Cornell University. He also was a founding partner of Ardana Capital, a pharmaceutical and biotechnology investment advisory firm. Dr. Traversa has over 25 years of experience in the healthcare sector, including management positions in the pharmaceutical industry and roles in investing and strategic advisory. He held financial analyst, portfolio management, and strategic advisory positions at U.S. investment firms such as Mehta and Isaly, Mehta Partners, ING Barings, Merlin BioMed, and Rx Capital. Previously, he was the Area Manager for Southern Europe of Therakos Inc., a cancer and immunology division of Johnson & Johnson. Before that, Dr. Traversa worked at Eli Lilly as Marketing Manager of the Hospital Business Unit and was part of the CNS team involved in the launch of Prozac and the early development of Zyprexa and Cymbalta. He began his career as a sales representative at Farmitalia Carlo Erba, which was later acquired by Pharmacia and is now part of Pfizer. Dr. Traversa also served as interim CEO and CFO of Actinium Pharmaceuticals, Inc. and is currently a board member of Actinium.

Maged Shenouda, Chief Financial Officer

Mr. Shenouda previously served as CFO and Executive Vice President of Corporate Development for AzurRx BioPharma, Inc.

Charles S. Ence, Chief Accounting and Compliance Officer

Charles Ence currently serves as Relmada Therapeutics' Chief Accounting and Compliance Officer.

Raj S. Pruthi, MD, Chief Medical Officer

Dr. Pruthi is an accomplished physician, surgeon, and clinical scientist with extensive experience in academic medicine and industry. Prior to joining Relmada, Dr. Pruthi was Chief Medical Officer at enGene Holdings Inc., where he led a global team in the development of a registrational therapeutic trial for bladder cancer. He also served as the Global Medical Affairs Leader, Bladder Cancer and Senior Medical Director, Oncology (Global – Prostate and Bladder Cancer) at Johnson and Johnson Innovative Medicine.

Paolo Manfredi, Chief Scientific Officer

Paolo Manfredi is the Chief Scientific Officer at Relmada Therapeutics.

AI Analysis | Feedback

Key Business Risks for Relmada Therapeutics (RLMD)

Relmada Therapeutics, Inc. (RLMD) faces several significant risks inherent to the biotechnology sector, particularly related to clinical trial outcomes, financial stability, and regulatory hurdles.
  1. Clinical Trial Failures and Pipeline Risk: The most prominent risk to Relmada Therapeutics is the high rate of failure in its clinical development programs. The company recently discontinued two Phase 3 trials (Reliance II and Relight) for its lead candidate, REL-1017, intended for major depressive disorder, after interim analyses indicated they were unlikely to achieve their primary efficacy endpoints. This follows a previous failure of REL-1017 in the Phase 3 RELIANCE III study. These repeated setbacks led to a substantial decline in the company's stock value and prompted Relmada to explore strategic alternatives, including a potential sale or merger. While the company is advancing other candidates like NDV-01 for non-muscle invasive bladder cancer into Phase 3, the inherent risk of clinical trial failure remains a critical concern for its remaining pipeline.
  2. Financial Instability and Funding Risk: Relmada Therapeutics has consistently operated at a loss, reporting a net loss of $21.8 million in Q1 2024 and an operating loss of approximately $98.54 million over the preceding twelve months. Analysts do not anticipate the company achieving profitability in the current year. The extensive costs associated with conducting late-stage clinical trials, especially for planned Phase 3 studies of NDV-01, necessitate substantial capital. Despite holding some cash and investments, concerns exist about the sufficiency of its cash runway, with estimates suggesting a limited timeframe based on current burn rates. This financial position indicates a high probability of future capital raises, which could lead to further dilution of shareholder value. The discontinuation of the REL-1017 trials further diminishes near-term revenue potential and compounds financial uncertainty.
  3. Regulatory Risk and Dependence on FDA Approvals: As a clinical-stage biotechnology company, Relmada's ability to bring its drug candidates to market is contingent upon navigating complex regulatory pathways and securing approvals from health authorities like the U.S. Food and Drug Administration (FDA). While the company has received positive feedback from the FDA regarding potential registrational pathways for NDV-01, ongoing and future interactions with regulatory bodies are subject to inherent uncertainties. Any delays in gaining regulatory alignment, or failure to meet FDA requirements for efficacy and safety, could significantly impact development timelines, increase costs, and jeopardize the commercial viability of its product candidates.

AI Analysis | Feedback

The emerging threat to Relmada Therapeutics stems from the rapid advancement and potential market entry of psychedelic-assisted therapies for Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD).

Companies like Compass Pathways, among others, are in late-stage clinical trials (e.g., Phase 3 for psilocybin in TRD) and have received regulatory designations such as FDA Breakthrough Therapy. These therapies offer a fundamentally different treatment paradigm compared to Relmada's lead candidate, REL-1017, which is a daily oral medication. Psychedelic-assisted therapies have demonstrated the potential for rapid, profound, and durable antidepressant effects after only a limited number of administrations (e.g., one or two doses), which could significantly reduce or eliminate the need for chronic daily medication over extended periods.

If these single or limited-dose therapies are approved and gain market acceptance, they could disrupt the market for daily oral antidepressants by shifting patient and prescriber preferences towards therapies offering long-term efficacy without the burden of continuous daily dosing. This represents a clear emerging threat that could fundamentally alter the competitive landscape for psychiatric treatments, similar to how streaming services disrupted physical media rentals.

AI Analysis | Feedback

Relmada Therapeutics, Inc. (RLMD) is a clinical-stage biotechnology company with a pipeline of product candidates targeting various central nervous system disorders and oncology. The addressable markets for their main products or services are as follows: * NDV-01 (for high-grade Non-Muscle Invasive Bladder Cancer - NMIBC): The U.S. NMIBC market is estimated to be a multi-billion dollar opportunity. Annually, 600,000 patients in the U.S. are affected by NMIBC. Global numbers for this market are projected to be higher due to increasing incidence of bladder cancer. * Sepranolone (for Tourette syndrome and Prader-Willi syndrome - PWS): For Tourette syndrome, the U.S. prevalence is approximately 350,000 patients. In the U.S., there are 20,000 patients with PWS. The global prevalence for PWS ranges from 350,000 to 400,000 patients. The company's prior lead product candidate, REL-1017, for Major Depressive Disorder (MDD), has had its Phase 3 trials discontinued due to futility.

AI Analysis | Feedback

Relmada Therapeutics (RLMD) faces a significant shift in its prospective revenue drivers following the discontinuation of its lead Major Depressive Disorder (MDD) drug, REL-1017, from Phase 3 trials due to a futility assessment. This has prompted the company to explore strategic alternatives, including potential sale of assets, merger, or acquisition of new products. Consequently, future revenue growth will hinge on the successful development and potential commercialization of its remaining pipeline and any outcomes from its strategic review. Here are 3-5 expected drivers of future revenue growth for Relmada Therapeutics over the next 2-3 years, contingent on successful clinical development and strategic execution:
  1. Advancement and Potential Commercialization of REL-P11 for Metabolic Diseases: Relmada is progressing with REL-P11, a proprietary low-dose, modified-release psilocybin formulation. Following the completion of a Phase 1 safety study, the company plans to initiate a Phase 2 study in the first half of 2025 for metabolic diseases. Positive results from this Phase 2 trial and subsequent successful clinical development could lead to its eventual commercialization, representing a new product line and significant revenue potential.
  2. Development and Commercialization of NDV-01 for Non-Muscle Invasive Bladder Cancer (NMIBC): The company is advancing NDV-01, a controlled-release intravesical formulation, which is currently in a Phase 2 clinical trial for aggressive forms of NMIBC. Success in ongoing and future clinical trials for NDV-01, leading to regulatory approval and market entry, would create a new revenue stream in the oncology space.
  3. Progression of Sepranolone for Neurological and Neuropsychiatric Disorders: Sepranolone, a neurosteroid epimer, is Phase 2b-ready for potential indications such as Prader-Willi Syndrome, Tourette Syndrome, and excessive tremor. Successful progression through clinical development and eventual commercialization of sepranolone would diversify Relmada's product portfolio and open new market opportunities.
  4. Strategic Transactions and Acquisition of New Assets: With the discontinuation of REL-1017, Relmada is actively exploring strategic alternatives to maximize shareholder value, including mergers, reverse mergers, or the acquisition of assets or development rights for other products. Should Relmada successfully acquire or license promising new product candidates, these could become significant drivers of future revenue growth within the 2-3 year timeframe, depending on their stage of development.

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Share Issuance

  • In November 2025, Relmada Therapeutics priced an underwritten offering of 40,142,000 shares of common stock and pre-funded warrants to purchase up to 5,315,000 shares, expecting to raise approximately $100 million in gross proceeds.
  • The common stock was offered at $2.20 per share, and pre-funded warrants at $2.199 per pre-funded warrant.
  • Net proceeds from this offering are intended to fund working capital, clinical studies, systems, and potential strategic investments.

Outbound Investments

  • In early 2025, Relmada Therapeutics strategically acquired development rights to two new product candidates: NDV-01, for non-muscle invasive bladder cancer, and sepranolone, for compulsion-related disorders.
  • As of February 2025, Relmada Therapeutics completed a Corporate Asset Purchase with Asarina Pharma for Tourette Syndrome Therapy Compound Rights.
  • In July 2021, the company acquired development and commercial rights to a novel psilocybin and derivate program from Arbormentis LLC for all ex-Asia territories, including the U.S. and Europe.

Capital Expenditures

  • Relmada Therapeutics' free cash flow, which is operating cash flow minus capital expenditures, was -$0.052 billion in 2024 and -$0.052 billion in 2023.
  • The company's free cash flow was -$0.104 billion in 2022 and -$0.092 billion in 2021.

Trade Ideas

Select ideas related to RLMD. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
CRL_11142025_Dip_Buyer_FCFYield11142025CRLCharles River Laboratories InternationalDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
21.4%21.4%-3.7%
GDRX_11142025_Dip_Buyer_High_CFO_Margins_ExInd_DE11142025GDRXGoodRxDip BuyDB | CFO/Rev | Low D/EDip Buy with High Cash Flow Margins
Buying dips for companies with significant cash flows from operations and reasonable debt / market cap
-7.4%-7.4%-11.8%
ASTH_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025ASTHAstrana HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
18.0%18.0%-5.5%
SGRY_11142025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11142025SGRYSurgery PartnersDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.9%3.9%-1.4%
TFX_11072025_Dip_Buyer_FCFYield11072025TFXTeleflexDip BuyDB | FCFY OPMDip Buy with High FCF Yield and High Margin
Buying dips for companies with high FCF yield and meaningfully high operating margin
12.2%12.2%-5.1%

Recent Active Movers

More From Trefis

Peer Comparisons for Relmada Therapeutics

Peers to compare with:

Financials

RLMDHPQHPEIBMCSCOAAPLMedian
NameRelmada .HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Price4.5123.2624.49305.0978.16273.4051.32
Mkt Cap0.121.932.6284.9309.24,074.4158.8
Rev LTM055,29534,29665,40257,696408,62556,496
Op Inc LTM-583,6241,64411,54412,991130,2147,584
FCF LTM-402,80062711,85412,73396,1847,327
FCF 3Y Avg-572,9781,40011,75313,879100,5037,366
CFO LTM-403,6972,91913,48313,744108,5658,590
CFO 3Y Avg-573,6723,89613,49814,736111,5598,697

Growth & Margins

RLMDHPQHPEIBMCSCOAAPLMedian
NameRelmada .HP Hewlett .Internat.Cisco Sy.Apple  
Rev Chg LTM-3.2%13.8%4.5%8.9%6.0%6.0%
Rev Chg 3Y Avg--3.9%6.5%2.6%3.7%1.8%2.6%
Rev Chg Q-4.2%14.4%9.1%7.5%9.6%9.1%
QoQ Delta Rev Chg LTM-1.1%3.7%2.1%1.8%2.1%2.1%
Op Mgn LTM-6.6%4.8%17.7%22.5%31.9%17.7%
Op Mgn 3Y Avg-7.4%7.2%16.4%24.2%30.8%16.4%
QoQ Delta Op Mgn LTM--0.2%-1.4%0.6%0.4%0.1%0.1%
CFO/Rev LTM-6.7%8.5%20.6%23.8%26.6%20.6%
CFO/Rev 3Y Avg-6.8%12.7%21.4%26.1%28.4%21.4%
FCF/Rev LTM-5.1%1.8%18.1%22.1%23.5%18.1%
FCF/Rev 3Y Avg-5.5%4.6%18.6%24.6%25.6%18.6%

Valuation

RLMDHPQHPEIBMCSCOAAPLMedian
NameRelmada .HP Hewlett .Internat.Cisco Sy.Apple  
Mkt Cap0.121.932.6284.9309.24,074.4158.8
P/S-0.41.04.45.410.04.4
P/EBIT-2.66.819.925.122.531.321.2
P/E-2.78.6572.736.029.941.033.0
P/CFO-3.75.911.221.122.537.516.2
Total Yield-37.5%14.1%2.3%5.0%5.4%2.8%3.9%
Dividend Yield0.0%2.5%2.1%2.2%2.1%0.4%2.1%
FCF Yield 3Y Avg-66.7%10.6%5.5%6.4%6.0%3.1%5.7%
D/E0.00.50.70.20.10.00.2
Net D/E-0.10.30.60.20.00.00.1

Returns

RLMDHPQHPEIBMCSCOAAPLMedian
NameRelmada .HP Hewlett .Internat.Cisco Sy.Apple  
1M Rtn7.6%-1.8%14.4%0.6%2.7%-1.5%1.7%
3M Rtn149.2%-11.9%2.7%7.9%17.0%7.1%7.5%
6M Rtn639.3%-4.0%34.5%6.6%15.2%36.3%24.9%
12M Rtn1,077.5%-27.0%16.2%40.5%34.5%7.5%25.3%
3Y Rtn40.9%-1.9%71.1%143.1%81.3%120.2%76.2%
1M Excs Rtn3.4%-5.6%12.9%-2.2%-0.0%-3.7%-1.1%
3M Excs Rtn144.9%-16.2%-1.7%3.6%12.7%2.8%3.2%
6M Excs Rtn627.1%-16.3%22.3%-5.7%3.0%24.0%12.6%
12M Excs Rtn1,072.1%-42.9%-0.7%25.0%19.9%-8.4%9.6%
3Y Excs Rtn-40.4%-83.5%-11.2%59.6%-1.2%28.4%-6.2%

Financials

Segment Financials

Assets by Segment
$ Mil20242023202220212020
Clinical stage drug development98153223118117
Total98153223118117


Price Behavior

Price Behavior
Market Price$4.51 
Market Cap ($ Bil)0.1 
First Trading Date03/16/2018 
Distance from 52W High-2.0% 
   50 Days200 Days
DMA Price$3.54$1.49
DMA Trendupup
Distance from DMA27.4%203.4%
 3M1YR
Volatility117.4%154.1%
Downside Capture75.72-59.91
Upside Capture504.71196.20
Correlation (SPY)18.4%10.2%
RLMD Betas & Captures as of 11/30/2025

 1M2M3M6M1Y3Y
Beta-1.580.990.210.290.640.72
Up Beta0.79-0.33-0.160.991.100.80
Down Beta-1.11-1.49-1.02-0.940.280.49
Up Capture389%757%757%504%17%22%
Bmk +ve Days13263974142427
Stock +ve Days12213461120345
Down Capture-681%14%-293%-295%-27%87%
Bmk -ve Days7162452107323
Stock -ve Days8192762126374

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
 Comparison of RLMD With Other Asset Classes (Last 1Y)
 RLMDSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return1,142.8%15.1%17.8%72.1%8.6%4.4%-8.2%
Annualized Volatility153.1%17.2%19.4%19.3%15.2%17.0%35.0%
Sharpe Ratio2.320.650.722.700.340.09-0.08
Correlation With Other Assets 8.0%9.8%-5.6%3.3%4.5%-3.4%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
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Based On 5-Year Data
 Comparison of RLMD With Other Asset Classes (Last 5Y)
 RLMDSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return-33.6%8.4%14.7%18.7%11.5%4.6%30.8%
Annualized Volatility111.9%14.5%17.1%15.5%18.7%18.9%48.6%
Sharpe Ratio0.310.400.700.970.500.160.57
Correlation With Other Assets 7.5%9.7%-0.6%1.6%9.5%2.1%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
 Comparison of RLMD With Other Asset Classes (Last 10Y)
 RLMDSector ETFEquityGoldCommoditiesReal EstateBitcoin
Annualized Return27.2%9.9%14.8%15.3%7.0%5.3%69.2%
Annualized Volatility167.6%16.6%18.0%14.7%17.6%20.8%55.8%
Sharpe Ratio0.770.490.710.860.320.220.90
Correlation With Other Assets 10.8%10.1%-2.6%2.1%9.3%2.7%

ETFs used for asset classes: Sector ETF = XLV, Equity = SPY, Gold = GLD, Commodities = DBC, Real Estate = VNQ, and Bitcoin = BTCUSD
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Short Interest

Short Interest: As Of Date12152025
Short Interest: Shares Quantity980,736
Short Interest: % Change Since 1130202526.9%
Average Daily Volume1,087,977
Days-to-Cover Short Interest1
Basic Shares Quantity33,191,622
Short % of Basic Shares3.0%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
11/13/20251.8%11.3%16.0%
8/7/2025-2.4%0.9%165.8%
3/27/2025-0.4%-7.4%19.8%
3/19/2024-17.4%-12.7%-19.9%
11/8/2023-0.3%1.0%-14.7%
8/8/20237.1%34.3%39.8%
3/23/2023-2.2%-3.4%8.2%
11/10/20228.7%2.7%-42.0%
...
SUMMARY STATS   
# Positive477
# Negative633
Median Positive7.3%2.7%16.0%
Median Negative-2.3%-7.4%-19.9%
Max Positive8.7%34.3%165.8%
Max Negative-17.4%-12.7%-42.0%

SEC Filings

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Report DateFiling DateFiling
93020251113202510-Q 9/30/2025
6302025807202510-Q 6/30/2025
3312025512202510-Q 3/31/2025
12312024327202510-K 12/31/2024
93020241107202410-Q 9/30/2024
6302024807202410-Q 6/30/2024
3312024508202410-Q 3/31/2024
12312023319202410-K 12/31/2023
93020231108202310-Q 9/30/2023
6302023808202310-Q 6/30/2023
3312023511202310-Q 3/31/2023
12312022323202310-K 12/31/2022
93020221110202210-Q 9/30/2022
6302022811202210-Q 6/30/2022
3312022505202210-Q 3/31/2022
12312021325202210-K 12/31/2021