Aktis Oncology (AKTS)
Market Price (3/29/2026): $15.25 | Market Cap: $-Sector: Health Care | Industry: Biotechnology
Aktis Oncology (AKTS)
Market Price (3/29/2026): $15.25Market Cap: $-Sector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
| Megatrend and thematic driversMegatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more. | Stock price has recently run up significantly6M Rtn6 month market price return is 9223372036854775807%, 12M Rtn12 month market price return is 253067% |
| High stock price volatilityVol 12M is 464% | |
| Key risksAKTS key risks include [1] its heavy dependence on a limited, Show more. |
| Megatrend and thematic driversMegatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more. |
| Stock price has recently run up significantly6M Rtn6 month market price return is 9223372036854775807%, 12M Rtn12 month market price return is 253067% |
| High stock price volatilityVol 12M is 464% |
| Key risksAKTS key risks include [1] its heavy dependence on a limited, Show more. |
Qualitative Assessment
AI Analysis | Feedback
Aktis Oncology (AKTS) stock has gained about 9223372036854775803% since 11/30/2025 because of the following key factors:
1. Successful Initial Public Offering (IPO) established market valuation from a prior non-public status.
Aktis Oncology began trading on the Nasdaq Global Select Market on January 9, 2026, at an initial public offering price of $18.00 per share, raising approximately $365.4 million in gross proceeds. This transition from having no public trading price to an $18.00 per share valuation is the fundamental reason for the extraordinary percentage gain from a theoretical zero base.
2. U.S. FDA Fast Track designation granted to its lead radiopharmaceutical candidate.
On February 24, 2026, Aktis Oncology announced that the U.S. Food and Drug Administration (FDA) granted Fast Track designation for AKY-1189, its lead radiopharmaceutical candidate, for adult patients with locally advanced or metastatic urothelial cancer who have progressed after prior systemic therapies. This designation can expedite the development and review process.
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1. Successful Initial Public Offering (IPO) established market valuation from a prior non-public status.
Aktis Oncology began trading on the Nasdaq Global Select Market on January 9, 2026, at an initial public offering price of $18.00 per share, raising approximately $365.4 million in gross proceeds. This transition from having no public trading price to an $18.00 per share valuation is the fundamental reason for the extraordinary percentage gain from a theoretical zero base.
2. U.S. FDA Fast Track designation granted to its lead radiopharmaceutical candidate.
On February 24, 2026, Aktis Oncology announced that the U.S. Food and Drug Administration (FDA) granted Fast Track designation for AKY-1189, its lead radiopharmaceutical candidate, for adult patients with locally advanced or metastatic urothelial cancer who have progressed after prior systemic therapies. This designation can expedite the development and review process.
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Stock Movement Drivers
Fundamental Drivers
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Market Drivers
11/30/2025 to 3/29/2026| Return | Correlation | |
|---|---|---|
| AKTS | ∞% | |
| Market (SPY) | -5.3% | � |
| Sector (XLV) | -8.7% | � |
Fundamental Drivers
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Market Drivers
8/31/2025 to 3/29/2026| Return | Correlation | |
|---|---|---|
| AKTS | ∞% | |
| Market (SPY) | 0.6% | � |
| Sector (XLV) | 5.2% | � |
Fundamental Drivers
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Market Drivers
2/28/2025 to 3/29/2026| Return | Correlation | |
|---|---|---|
| AKTS | 126483.3% | |
| Market (SPY) | 9.8% | � |
| Sector (XLV) | -2.1% | � |
Fundamental Drivers
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Market Drivers
2/28/2023 to 3/29/2026| Return | Correlation | |
|---|---|---|
| AKTS | 306.1% | |
| Market (SPY) | 69.4% | � |
| Sector (XLV) | 18.4% | � |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| AKTS Return | -45% | -58% | -70% | -99% | -100% | ∞% | -100% |
| Peers Return | 29% | 34% | 13% | -0% | 2% | 8% | 115% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | -5% | 72% |
Monthly Win Rates [3] | |||||||
| AKTS Win Rate | 25% | 50% | 50% | 25% | 33% | 0% | |
| Peers Win Rate | 45% | 60% | 40% | 53% | 55% | 60% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 33% | |
Max Drawdowns [4] | |||||||
| AKTS Max Drawdown | -49% | -65% | -83% | -99% | -100% | - | |
| Peers Max Drawdown | -11% | -20% | -26% | -29% | -29% | -12% | |
| S&P 500 Max Drawdown | -1% | -25% | -1% | -2% | -15% | -5% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: LNTH, ATNM, CATX, LLY, BMY.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 3/27/2026 (YTD)
How Low Can It Go
| Event | AKTS | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -97.4% | -25.4% |
| % Gain to Breakeven | 3770.8% | 34.1% |
| Time to Breakeven | 802 days | 464 days |
| 2020 Covid Pandemic | ||
| % Loss | -53.7% | -33.9% |
| % Gain to Breakeven | 115.9% | 51.3% |
| Time to Breakeven | 38 days | 148 days |
| 2018 Correction | ||
| % Loss | -73.3% | -19.8% |
| % Gain to Breakeven | 274.6% | 24.7% |
| Time to Breakeven | 802 days | 120 days |
Compare to LNTH, ATNM, CATX, LLY, BMY
In The Past
Aktis Oncology's stock fell -97.4% during the 2022 Inflation Shock from a high on 2/5/2021. A -97.4% loss requires a 3770.8% gain to breakeven.
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About Aktis Oncology (AKTS)
Akoustis Technologies, Inc., through its subsidiary, Akoustis, Inc., develops, designs, manufactures, and sells radio frequency (RF) filter products for the mobile wireless device industry in the United States. It operates through two segments, Foundry Fabrication Services and RF Filters. The Foundry Fabrication Services segment provides engineering review services; and semiconductor wafer-manufacturing and microelectromechanical systems foundry services. The RF Filters segment consists of amplifier and filter products. It offers RF filters for mobile wireless devices, such as smartphones and tablets, cellular infrastructure equipment, Wi-Fi customer premise equipment, and military and defense applications. The company was incorporated in 2013 and is headquartered in Huntersville, North Carolina.
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- It's like Corning, but instead of making specialized glass for smartphone screens, Akoustis makes the high-performance filters essential for wireless communication in your phone and Wi-Fi.
- Think of it as a specialized TSMC or GlobalFoundries, but entirely focused on designing and manufacturing advanced radio frequency filters and MEMS for wireless devices.
- It's like the "Intel Inside" for wireless communication, creating the critical filter components that enable your smartphone, Wi-Fi, and other wireless tech to function reliably.
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Here are the key risks to Aktis Oncology's business:
- Clinical Development and Regulatory Risk: As a clinical-stage oncology company, Aktis Oncology's success is heavily dependent on the successful development, clinical trials, and regulatory approval of its product candidates, such as AKY-1189 and AKY-2519. The company's lead candidate, AKY-1189, recently received FDA Fast Track designation for advanced urothelial cancer, which can accelerate development and review but does not mitigate the inherent scientific or clinical risks. Uncertainties exist regarding the progression and safety data from ongoing trials like NECTINIUM-2 Phase 1b, and the potential for its therapies to address a broad range of tumor types beyond those initially targeted remains to be fully established.
- Financial Risk and Reliance on External Funding: Aktis Oncology is currently unprofitable and is not expected to achieve profitability within the next three years, with analysts forecasting an average annual earnings decline of 25.5% over this period. The company is in an investment-heavy phase and will likely need to rely on external funding to finance its research and development activities and advance its pipeline. The ability to secure sufficient capital and manage its cash runway effectively are critical financial considerations.
- Supply Chain Risk for Alpha-Emitting Isotopes: Aktis Oncology specializes in developing radiopharmaceutical therapies that utilize alpha-emitting isotopes, such as Actinium-225. The availability and consistent supply of these specialized isotopes are crucial for the development and potential commercialization of their products. Fluctuations in the supply chain or changes in the landscape of alpha-emitting isotope production could pose a risk to the company's operations and strategy.
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Aktis Oncology (symbol: AKTS) operates in the radiopharmaceutical market, developing targeted radiopharmaceuticals for solid tumors. The company's main product candidates include AKY-1189, which targets Nectin-4 for urothelial cancer and other Nectin-4 expressing tumors, and AKY-2519, which targets B7-H3 for prostate and lung cancers. The addressable market for radiopharmaceuticals is projected to exceed **$26 billion globally by 2032**. The therapeutic segment of this market is estimated to reach **$25–$60 billion globally post-2030**. More broadly, the radiopharmaceutical market was valued at $6.2 billion in 2024 and is projected to reach $19.6 billion by 2034, demonstrating a compound annual growth rate (CAGR) of 12.7%. Aktis Oncology's lead candidate, AKY-1189, targets Nectin-4, which is expressed in approximately 80% to 90% of urothelial cancers, indicating a significant addressable patient population if successful. Nectin-4 is also expressed in other high-incidence tumor types.AI Analysis | Feedback
Aktis Oncology, Inc. (NASDAQ: AKTS) is a clinical-stage oncology company focused on developing targeted radiopharmaceuticals for solid tumors. As such, its future revenue growth over the next 2-3 years will primarily be driven by the progression of its pipeline and potential market entry of its therapeutic candidates. The key drivers are expected to be:- Advancement and Commercialization of its Miniprotein Radioconjugate Platform and Pipeline Products: Aktis Oncology's core strategy revolves around its proprietary miniprotein radioconjugate platform, designed to deliver tumor-killing radioisotopes to targeted tumors. The successful advancement of its pipeline products, such as AKY-1189, through clinical trials, regulatory approvals, and eventual commercial launch, will be the primary driver of future revenue. AKY-1189, a Nectin-4 miniprotein radioconjugate, has already received U.S. FDA Fast Track Designation for the treatment of locally advanced or metastatic urothelial cancer, which could expedite its development and review process.
- Expansion into New Cancer Indications and Patient Populations: A central part of Aktis Oncology's mission is to expand the potential of targeted radiopharmaceuticals to broad patient populations, including those not currently addressed by existing technologies. The company aims to achieve this by developing next-generation technologies that broaden the spectrum of tumor targets for effective radiopharmaceutical delivery. Successfully expanding its therapies to new solid tumor types, such as breast, lung, colorectal, bladder, and liver cancers, will unlock significant new market opportunities and contribute to revenue growth.
- Strategic Collaborations and Partnerships: As a clinical-stage biotechnology company, strategic collaborations and partnerships are crucial for funding research and development, mitigating risks, and accelerating market access. The company has already garnered "substantial backing from Big Pharma mainstay Eli Lilly", suggesting a precedent for such alliances. Future agreements for co-development, licensing, or commercialization of its platform or pipeline assets could provide significant upfront payments, milestone achievements, and royalties, thereby contributing to its revenue streams.
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| Date | Ticker | Company | Category | Trade Strategy | 6M Fwd Rtn | 12M Fwd Rtn | 12M Max DD |
|---|---|---|---|---|---|---|---|
| 02282026 | QDEL | QuidelOrtho | Insider | Insider Buys 45DStrong Insider BuyingCompanies with multiple insider buys in the last 45 days | 0.0% | 0.0% | 0.0% |
| 02272026 | CHE | Chemed | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 0.0% | 0.0% | 0.0% |
| 02272026 | LLY | Eli Lilly | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | 0.0% | 0.0% | 0.0% |
| 02202026 | HAE | Haemonetics | Dip Buy | DB | FCFY OPMDip Buy with High FCF Yield and High MarginBuying dips for companies with high FCF yield and meaningfully high operating margin | 3.5% | 3.5% | 0.0% |
| 02132026 | IQV | IQVIA | Dip Buy | DB | P/E OPMDip Buy with Low PE and High MarginBuying dips for companies with tame PE and meaningfully high operating margin | 7.1% | 7.1% | -3.0% |
Research & Analysis
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Peer Comparisons
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Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 36.87 |
| Mkt Cap | 4.9 |
| Rev LTM | 1,542 |
| Op Inc LTM | 316 |
| FCF LTM | 349 |
| FCF 3Y Avg | 348 |
| CFO LTM | 390 |
| CFO 3Y Avg | 413 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 5.8% |
| Rev Chg 3Y Avg | 19.2% |
| Rev Chg Q | 4.0% |
| QoQ Delta Rev Chg LTM | 1.0% |
| Op Mgn LTM | 24.5% |
| Op Mgn 3Y Avg | 25.9% |
| QoQ Delta Op Mgn LTM | 1.1% |
| CFO/Rev LTM | 25.6% |
| CFO/Rev 3Y Avg | 28.1% |
| FCF/Rev LTM | 15.9% |
| FCF/Rev 3Y Avg | 23.7% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 4.9 |
| P/S | 7.6 |
| P/EBIT | 10.6 |
| P/E | 16.9 |
| P/CFO | 8.4 |
| Total Yield | 3.3% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | 0.0% |
| D/E | 0.1 |
| Net D/E | 0.0 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | -14.6% |
| 3M Rtn | 7.1% |
| 6M Rtn | 21.6% |
| 12M Rtn | 5.0% |
| 3Y Rtn | -4.7% |
| 1M Excs Rtn | -4.4% |
| 3M Excs Rtn | 16.4% |
| 6M Excs Rtn | 31.2% |
| 12M Excs Rtn | -6.1% |
| 3Y Excs Rtn | -65.6% |
Price Behavior
Price Behavior
| Market Price | $15.19 | |
| First Trading Date | 03/13/2017 | |
| Distance from 52W High | -32.2% | |
| 50 Days | 200 Days | |
| DMA Price | $19.33 | $5.27 |
| DMA Trend | up | up |
| Distance from DMA | -21.4% | 188.5% |
| 3M | 1YR | |
| Volatility | 67.0% | � |
| Downside Capture | 2.03 | � |
| Upside Capture | 168.09 | � |
| Correlation (SPY) | � | � |
AKTS Betas & Captures as of 2/28/2026
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 0.43 | 1.18 | 1.62 | � | � | � |
| Up Beta | -2.21 | 0.49 | -2.91 | � | � | � |
| Down Beta | 0.52 | -1.12 | -1.69 | � | � | � |
| Up Capture | 114% | 137% | 95% | � | � | � |
| Bmk +ve Days | 9 | 20 | 31 | 70 | 142 | 431 |
| Stock +ve Days | 11 | 13 | 13 | 14 | 33 | 245 |
| Down Capture | 117% | 211% | 160% | � | � | � |
| Bmk -ve Days | 12 | 21 | 30 | 54 | 109 | 320 |
| Stock -ve Days | 10 | 20 | 20 | 21 | 51 | 329 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with AKTS | |
|---|---|---|---|---|
| AKTS | -100.0% | 424.7% | -2.83 | - |
| Sector ETF (XLV) | 0.3% | 17.6% | -0.13 | -5.7% |
| Equity (SPY) | 14.5% | 18.9% | 0.59 | -0.2% |
| Gold (GLD) | 50.2% | 27.7% | 1.46 | -1.1% |
| Commodities (DBC) | 17.8% | 17.6% | 0.85 | 3.2% |
| Real Estate (VNQ) | 0.4% | 16.4% | -0.15 | 0.1% |
| Bitcoin (BTCUSD) | -23.7% | 44.2% | -0.49 | -8.1% |
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Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with AKTS | |
|---|---|---|---|---|
| AKTS | -100.0% | 197.5% | -1.01 | - |
| Sector ETF (XLV) | 6.0% | 14.5% | 0.23 | 11.3% |
| Equity (SPY) | 11.8% | 17.0% | 0.54 | 16.8% |
| Gold (GLD) | 20.7% | 17.7% | 0.96 | 2.7% |
| Commodities (DBC) | 11.6% | 18.9% | 0.50 | 5.0% |
| Real Estate (VNQ) | 3.0% | 18.8% | 0.07 | 15.8% |
| Bitcoin (BTCUSD) | 4.0% | 56.6% | 0.29 | 5.0% |
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Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with AKTS | |
|---|---|---|---|---|
| AKTS | -100.0% | 145.3% | -0.42 | - |
| Sector ETF (XLV) | 9.7% | 16.5% | 0.48 | 12.2% |
| Equity (SPY) | 14.0% | 17.9% | 0.67 | 17.7% |
| Gold (GLD) | 13.3% | 15.8% | 0.70 | 2.9% |
| Commodities (DBC) | 8.2% | 17.6% | 0.39 | 6.8% |
| Real Estate (VNQ) | 4.7% | 20.7% | 0.19 | 14.9% |
| Bitcoin (BTCUSD) | 66.4% | 66.8% | 1.06 | 6.1% |
Smart multi-asset allocation framework can stack odds in your favor. Learn How
Earnings Returns History
Expand for More| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| SUMMARY STATS | |||
| # Positive | 0 | 0 | 0 |
| # Negative | 0 | 0 | 0 |
| Median Positive | |||
| Median Negative | |||
| Max Positive | |||
| Max Negative | |||
Insider Activity
Expand for More| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Ecor1, Capital, Llc | See Note | Buy | 1122026 | 18.00 | 2,222,222 | 39,999,996 | 78,275,844 | Form | |
| 2 | Vida, Ventures Ii, Llc | See Footnote | Buy | 1122026 | 18.00 | 835,000 | 15,030,000 | 102,092,850 | Form | |
| 3 | Kim, Helen Susan | See Footnote | Buy | 1122026 | 18.00 | 835,000 | 15,030,000 | 102,092,850 | Form |
Industry Resources
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