Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -317%

Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -104%, 3Y Excs Rtn is -154%

Penny stock
Mkt Price is 0.7

Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -5.4 Mil

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -55%

High stock price volatility
Vol 12M is 101%

Key risks
PMCB key risks include [1] an ongoing FDA clinical hold on its lead therapy's drug application and [2] material weaknesses in internal controls combined with delayed financial filings.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -317%
1 Megatrend and thematic drivers
Megatrends include Aging Population & Chronic Disease, and Precision Medicine. Themes include Oncology Treatments, Targeted Therapies, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -104%, 3Y Excs Rtn is -154%
3 Penny stock
Mkt Price is 0.7
4 Very low revenue
Rev LTMTotal Revenue or Sales, Last Twelve Months is 0
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -5.4 Mil
6 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -55%
7 High stock price volatility
Vol 12M is 101%
8 Key risks
PMCB key risks include [1] an ongoing FDA clinical hold on its lead therapy's drug application and [2] material weaknesses in internal controls combined with delayed financial filings.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 6/3/2026

PharmaCyte Biotech (PMCB) stock has remained largely at the same level since 2/28/2026 because of the following key factors:

1. Significant progress in addressing FDA clinical hold. PharmaCyte Biotech successfully completed the twelve-month product stability testing for its CypCaps™ final clinical trial product on May 5, 2026. This achievement is a crucial step towards having the U.S. Food and Drug Administration (FDA) clinical hold lifted for its planned Phase 2b clinical trial in locally advanced, inoperable pancreatic cancer.

2. Strengthened liquidity and financial position. While occurring prior to the specified period, the successful monetization of PharmaCyte's stake in Femasys in November 2025 significantly boosted the company's liquidity. This increased cash and marketable securities to approximately $20 million in cash and roughly $25 million in marketable securities, providing a strong financial foundation and enabling strategic capital deployment that continued to positively influence investor confidence in the subsequent period.

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Stock Movement Drivers

Fundamental Drivers

The 1.4% change in PMCB stock from 2/28/2026 to 6/5/2026 was primarily driven by a 0.0% change in the company's Total Revenues ($ Mil).
(LTM values as of)22820266052026Change
Stock Price ($)0.690.701.4%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)79-26.6%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2026 to 6/5/2026
ReturnCorrelation
PMCB1.4% 
Market (SPY)7.8%13.8%
Sector (XLV)-4.1%16.7%

Fundamental Drivers

The -9.5% change in PMCB stock from 11/30/2025 to 6/5/2026 was primarily driven by a -26.6% change in the company's Shares Outstanding (Mil).
(LTM values as of)113020256052026Change
Stock Price ($)0.770.70-9.5%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)79-26.6%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

11/30/2025 to 6/5/2026
ReturnCorrelation
PMCB-9.5% 
Market (SPY)8.5%16.0%
Sector (XLV)-2.1%3.0%

Fundamental Drivers

The -31.7% change in PMCB stock from 5/31/2025 to 6/5/2026 was primarily driven by a -24.9% change in the company's Shares Outstanding (Mil).
(LTM values as of)53120256052026Change
Stock Price ($)1.030.70-31.7%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)79-24.9%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2025 to 6/5/2026
ReturnCorrelation
PMCB-31.7% 
Market (SPY)26.6%15.4%
Sector (XLV)17.4%10.5%

Fundamental Drivers

The -77.8% change in PMCB stock from 5/31/2023 to 6/5/2026 was primarily driven by a 105.1% change in the company's Shares Outstanding (Mil).
(LTM values as of)53120236052026Change
Stock Price ($)3.150.70-77.8%
Change Contribution By: 
Total Revenues ($ Mil)000.0%
P/S Multiple0.0%
Shares Outstanding (Mil)199105.1%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2023 to 6/5/2026
ReturnCorrelation
PMCB-77.8% 
Market (SPY)83.4%15.7%
Sector (XLV)25.8%10.4%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
PMCB Return10317%17%-26%-27%-54%0%2922%
Peers Return-7%32%41%-1%2%5%83%
S&P 500 Return27%-19%24%23%16%11%102%

Monthly Win Rates [3]
PMCB Win Rate8%50%42%25%33%50% 
Peers Win Rate42%67%58%50%67%42% 
S&P 500 Win Rate75%42%67%75%67%67% 

Max Drawdowns [4]
PMCB Max Drawdown-76%-31%-37%-42%-65%-34% 
Peers Max Drawdown-27%-19%-12%-23%-29%-29% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: VRTX, ALPS, AVLN, DFTX, EIKN.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 6/5/2026 (YTD)

How Low Can It Go

EventPMCBS&P 500
2022 Inflation Shock & Fed Tightening
  % Loss-31.0%-24.5%
  % Gain to Breakeven45.0%32.4%
  Time to Breakeven172 days427 days
2020 COVID-19 Crash
  % Loss-46.7%-33.7%
  % Gain to Breakeven87.5%50.9%
  Time to Breakeven502 days140 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-24.4%-17.9%
  % Gain to Breakeven32.2%21.8%
  Time to Breakeven32 days123 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-26.3%-15.4%
  % Gain to Breakeven35.7%18.2%
  Time to Breakeven36 days125 days
2008-2009 Global Financial Crisis
  % Loss-83.8%-53.4%
  % Gain to Breakeven516.7%114.4%
  Time to Breakeven1678 days1085 days

Compare to VRTX, ALPS, AVLN, DFTX, EIKN

In The Past

PharmaCyte Biotech's stock fell -7.7% during the 2023 SVB Regional Banking Crisis. Such a loss loss requires a 8.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventPMCBS&P 500
2022 Inflation Shock & Fed Tightening
  % Loss-31.0%-24.5%
  % Gain to Breakeven45.0%32.4%
  Time to Breakeven172 days427 days
2020 COVID-19 Crash
  % Loss-46.7%-33.7%
  % Gain to Breakeven87.5%50.9%
  Time to Breakeven502 days140 days
2011 US Debt Ceiling Crisis & European Contagion
  % Loss-24.4%-17.9%
  % Gain to Breakeven32.2%21.8%
  Time to Breakeven32 days123 days
2010 Eurozone Sovereign Debt Crisis / Flash Crash
  % Loss-26.3%-15.4%
  % Gain to Breakeven35.7%18.2%
  Time to Breakeven36 days125 days
2008-2009 Global Financial Crisis
  % Loss-83.8%-53.4%
  % Gain to Breakeven516.7%114.4%
  Time to Breakeven1678 days1085 days

Compare to VRTX, ALPS, AVLN, DFTX, EIKN

In The Past

PharmaCyte Biotech's stock fell -7.7% during the 2023 SVB Regional Banking Crisis. Such a loss loss requires a 8.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About PharmaCyte Biotech (PMCB)

PharmaCyte Biotech, Inc., a biotechnology company, focuses on developing and commercializing cellular therapies for cancer and diabetes in the United States. Its cellular therapies are developed based on Cell-in-a-Box, a proprietary cellulose-based live cell encapsulation technology used as a platform to treat various types of cancer, including advanced and inoperable non-metastatic pancreatic cancer, as well as diabetes. The company is developing therapies for pancreatic and other tumors, including encapsulated genetically modified living cells. It is also developing a therapy for Type 1 diabetes and insulin-dependent Type 2 diabetes; and therapies for cancer based on the constituents of the cannabis plant. The company has a research agreement with the University of Technology, Sydney to create a version of melligen cells to treat diabetes; and the University of Northern Colorado to develop methods for the identification, separation, and quantification of constituents of cannabis. The company was formerly known as Nuvilex, Inc. and changed its name to PharmaCyte Biotech, Inc. in January 2015. PharmaCyte Biotech, Inc. was incorporated in 1996 and is based in Laguna Hills, California.

AI Analysis | Feedback

Here are 1-3 brief analogies for PharmaCyte Biotech (PMCB):

  • Moderna, but for encapsulated living cells rather than mRNA, targeting cancer and diabetes.
  • A smaller, early-stage Novartis focused on developing a proprietary 'Cell-in-a-Box' technology for cellular therapies against cancer and diabetes.

AI Analysis | Feedback

  • Cellular Therapies for Pancreatic and Other Tumors: These therapies utilize the proprietary Cell-in-a-Box encapsulation technology with genetically modified living cells to treat various cancers, including advanced and inoperable non-metastatic pancreatic cancer.
  • Cellular Therapies for Type 1 and Insulin-Dependent Type 2 Diabetes: Developed using the Cell-in-a-Box platform, these therapies aim to treat both Type 1 and insulin-dependent Type 2 diabetes.
  • Cannabis-Based Therapies for Cancer: These are therapies under development that leverage the constituents of the cannabis plant for cancer treatment.

AI Analysis | Feedback

Based on the provided company description, PharmaCyte Biotech (PMCB) is a biotechnology company primarily focused on developing and commercializing cellular therapies for cancer and diabetes. The background information indicates that the company is largely engaged in the research and development phase of its proprietary "Cell-in-a-Box" technology and associated therapies.

As of the provided description, no specific major commercial customers are identified as currently purchasing PharmaCyte Biotech's products or therapies. Biotech companies at this stage often do not have major commercial customers in the traditional sense, as their products are typically undergoing extensive clinical trials and awaiting regulatory approval.

However, once PharmaCyte Biotech's therapies are fully developed, approved, and ready for market, its customer base would primarily consist of companies and institutions within the healthcare sector. The categories of customers it would likely serve include:

  1. Healthcare Providers: This category encompasses hospitals, specialized clinics (e.g., oncology centers, diabetes treatment centers), and individual medical practitioners (oncologists, endocrinologists) who would purchase and administer the approved cellular therapies to patients.
  2. Pharmaceutical Distributors/Wholesalers: These companies would play a crucial role in the supply chain, handling the storage, logistics, and distribution of the therapies from PharmaCyte Biotech to various healthcare providers.
  3. Pharmaceutical Partners: PharmaCyte Biotech may enter into licensing agreements, co-development deals, or distribution partnerships with larger pharmaceutical companies. In such scenarios, these larger pharma companies would effectively be "customers" for PharmaCyte Biotech's intellectual property, developed therapies, or manufacturing capabilities, enabling broader market reach.

Given the nature of advanced cellular therapies for complex diseases, PharmaCyte Biotech does not appear to sell its products directly to individual consumers or patients.

AI Analysis | Feedback

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Joshua N. Silverman – Interim Chief Executive Officer, President, and Director

Joshua N. Silverman currently serves as the Interim CEO, President, and a Director of PharmaCyte Biotech, and has also been the Interim Chairman of the Board since October 2022. He is the Co-Founder and Managing Member of Parkfield Funding LLC and was a Principal and Managing Partner of Iroquois Capital Management, LLC, where he served as Co-Chief Investment Officer from 2003 until July 2016. Prior to Iroquois, he was Co-Chief Investment Officer of Vertical Ventures, LLC, a merchant bank, from 2000 to 2003. Mr. Silverman also worked as a Director at Joele Frank, a consulting firm specializing in mergers and acquisitions, and previously served as Assistant Press Secretary to The President of The United States. He currently sits on the boards of directors for Ayro Inc., MYMD Pharmaceuticals, Inc., Petros Pharmaceuticals, Inc., and Synaptogenix, Inc. PharmaCyte Biotech recently monetized its stake in Femasys Inc., an entity where Mr. Silverman serves on the board.

Carlos A. Trujillo, CPA – Chief Financial Officer

Carlos A. Trujillo is the Chief Financial Officer of PharmaCyte Biotech and also serves as the Principal Accounting Officer and a member of PharmaCyte's Board of Directors. He is a Certified Public Accountant licensed in California with 35 years of experience in finance, accounting, and management. Mr. Trujillo began his career in public accounting as an audit department manager and later operated his own consulting and accounting practice for a decade, providing CFO services to organizations across various industries, including biotechnology, telecommunications, manufacturing, construction, and real estate development. For the past eleven years, he has held CFO positions for both privately-held and publicly-traded multinational companies, bringing extensive experience in preparing and filing periodic reports with the Securities and Exchange Commission, mergers and acquisitions, and comprehensive financial statement reporting.

Dr. José Iglesias M.D. – Consulting Chief Medical Officer

Dr. José Iglesias serves as the Consulting Chief Medical Officer for PharmaCyte Biotech. He contributes a wealth of experience in the development and testing of cancer chemotherapeutic agents, having held key positions at prominent biotechnology firms such as Eli Lilly, Amgen, Abraxis, and Celgene. Notably, as the global Vice-President of Clinical Development at Celgene, Dr. Iglesias was the lead physician for the team that secured FDA approval for Abraxane®, a first-line therapy for pancreatic cancer.

Robert Weinstein – Director

Robert Weinstein has been a director of PharmaCyte Biotech since November 2022. He currently holds the position of Chief Financial Officer at Synaptogenix, Inc. (Nasdaq: SNPX) since October 2013, and also works as a consultant for Petros Pharmaceuticals, Inc. (Nasdaq: PTPI). With over 30 years of experience, Mr. Weinstein's background spans public accounting, investment banking, serving as a principal in a healthcare private equity fund, and various chief financial officer roles. From August 2007 to February 2010, he was the CFO of Xcorporeal, Inc., a development-stage medical device company that was acquired by Fresenius Medical USA in March 2010.

Wayne R. Walker – Director

Wayne R. Walker joined PharmaCyte Biotech's board of directors in December 2022. He brings over 35 years of experience in corporate governance, turnaround management, corporate restructuring, and bankruptcy matters. Since 1998, Mr. Walker has been the founder and president of Walker Nell Partners, Inc., an international business consulting firm.

AI Analysis | Feedback

The key risks to PharmaCyte Biotech (PMCB) are primarily associated with the inherent uncertainties of biotechnology drug development.

  1. Clinical Trial and Regulatory Approval Risk: PharmaCyte Biotech's therapies, including those for advanced pancreatic cancer and diabetes, are currently in development and have not yet received regulatory approvals. There is a significant risk that these cellular therapies may fail to demonstrate efficacy or safety in clinical trials, or may not meet the stringent requirements for regulatory approval (e.g., from the FDA). Failure at any stage of the costly and lengthy clinical development process could significantly impede or halt the commercialization of its product candidates.

  2. Reliance on a Single Core Technology: The company's entire therapeutic platform is based on its proprietary "Cell-in-a-Box" live cell encapsulation technology. The success of PharmaCyte's pipeline, which aims to treat various cancers and diabetes, is heavily dependent on the continued viability, safety, and efficacy of this specific technology. Any unforeseen limitations, side effects, manufacturing challenges, or failures in the application of the Cell-in-a-Box technology could jeopardize the entire product portfolio.

  3. Financing Risk and Capital Needs: As a biotechnology company primarily engaged in research and development, PharmaCyte Biotech is likely to incur significant expenses without generating substantial revenue until its therapies are successfully commercialized. Developing and bringing novel cellular therapies to market, especially for complex diseases like cancer and diabetes, requires substantial capital for preclinical studies, clinical trials, regulatory submissions, and potential commercialization efforts. The company faces an ongoing risk of needing to raise additional capital, which may not be available on favorable terms or at all, potentially leading to delays or abandonment of development programs.

AI Analysis | Feedback

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PharmaCyte Biotech (PMCB) operates in several significant addressable markets for its cellular therapies:

Pancreatic Cancer Treatment Market

PharmaCyte Biotech is developing cellular therapies for advanced and inoperable non-metastatic pancreatic cancer using its Cell-in-a-Box technology.

  • The global pancreatic cancer treatment market was estimated at approximately $2.92 billion in 2024 and is projected to reach $5.84 billion by 2030, growing at a Compound Annual Growth Rate (CAGR) of 12.3% from 2025 to 2030.
  • Other estimates place the global pancreatic cancer market size at $3.54 billion in 2024, expected to reach around $13.93 billion by 2034 with a CAGR of approximately 14.68% between 2025 and 2034.
  • Another report indicated the global market was valued at $3.28 billion in 2025 and is likely to cross $12.05 billion by 2035, registering over a 13.9% CAGR.
  • North America accounted for the largest share of the pancreatic cancer treatment market in 2024. The U.S. alone accounted for nearly 50% of the total market size among the 7 major markets in 2023.

Cannabis-Based Cancer Therapies Market

PharmaCyte Biotech is also developing therapies for cancer based on constituents of the cannabis plant (cannabinoids), intending to combine these with their Cell-in-a-Box technology for difficult-to-treat cancers.

  • The global cannabinoid-based products for cancer market was valued at approximately $2.8 billion in 2023 and is anticipated to reach $9.5 billion by 2033, growing at a CAGR of 12.8% from 2024 to 2033.
  • More broadly, the global medical cannabis market was valued at $18.1 billion in 2023 and is projected to reach $122.7 billion by 2032, exhibiting a robust CAGR of 23.7%.
  • Other estimations for the global medical cannabis market include $25.86 billion in 2024, expected to reach $133.73 billion by 2032, growing at a CAGR of 22.80%. Another source valued the global medical cannabis market at $39.6 billion in 2025, with an expectation to reach $74.3 billion by 2034 at a CAGR of 6.90%.
  • North America holds the largest share in the medical cannabis market.

Diabetes Treatment Market (Type 1 and Insulin-Dependent Type 2 Diabetes)

PharmaCyte Biotech is developing a cellular therapy for Type 1 diabetes and insulin-dependent Type 2 diabetes designed to function as a "bio-artificial pancreas" by producing and releasing insulin.

Type 1 Diabetes Treatment Market

  • The global Type 1 Diabetes Treatment market size is projected to grow from $7.2 billion in 2023 to an estimated $12.6 billion by 2032, at a CAGR of 6.5%.
  • Another report states the global Type 1 Diabetes Market Size was approximately $16.01 billion in 2024 and is predicted to grow to around $31.48 billion by 2035 with a CAGR of 6.34% from 2025 to 2035.
  • A different estimate places the global market size at $37.60 billion in 2025, predicted to increase to approximately $79.14 billion by 2035, expanding at a CAGR of 7.73%.
  • North America accounts for approximately 38%–40% of the global Type 1 Diabetes Treatment Market Share.

Insulin-Dependent Type 2 Diabetes Treatment Market

  • The global Type 2 Diabetes Mellitus treatment market generated a revenue of $57.47 billion in 2023 and is expected to reach $91.97 billion by 2030, growing at a CAGR of 6.9% from 2024 to 2030.
  • Insulin accounted for a significant portion of the revenue within the Type 2 Diabetes Mellitus treatment market.
  • North America was the largest revenue-generating market for Type 2 Diabetes Mellitus treatment in 2023.

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Expected Drivers of Future Revenue Growth for PharmaCyte Biotech (PMCB)

For PharmaCyte Biotech (PMCB), a clinical-stage biotechnology company with no current commercialized products, future revenue growth over the next 2-3 years is entirely dependent on the successful advancement and potential commercialization of its pipeline therapies. The primary drivers are centered on clinical development and regulatory milestones for its lead product candidates:

  1. Advancement of CypCaps for Pancreatic Cancer: A key driver will be the successful resolution of the U.S. FDA clinical hold on its Phase 2b trial for locally advanced, inoperable pancreatic cancer (LAPC) and the subsequent progression of this trial. The company has been actively conducting required studies, including product stability tests and biocompatibility assessments, and initiated pig studies to address FDA concerns. Successful clinical outcomes and further advancement in this program are critical steps toward potential market entry and revenue generation.
  2. Progression of Diabetes Therapy Development: The ongoing development of PharmaCyte's therapy for Type 1 and insulin-dependent Type 2 diabetes, utilizing its Cell-in-a-Box encapsulation technology with genetically modified Melligen cells, is another expected driver. Continued preclinical and clinical progress in this program, moving it closer to human trials and eventual commercialization, would contribute to future revenue potential.
  3. Achievement of Key Regulatory Milestones: Obtaining significant regulatory milestones, such as successful completion of clinical trial phases and the submission of regulatory applications (e.g., Biologics License Application), will be essential for future revenue. While full market approval and product launch might extend beyond the immediate 2-3 year timeframe, achieving these critical regulatory steps for its lead candidates would de-risk the programs and position the company for eventual revenue generation.

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Share Repurchases

  • In May 2022, PharmaCyte Biotech's board authorized a share repurchase program for up to $10 million.
  • An additional share repurchase program for up to $10 million was authorized by the board in January 2023.

Share Issuance

  • PharmaCyte Biotech completed a 1-for-1,500 reverse stock split on July 12, 2021, which reduced the number of outstanding shares from approximately 2.4 billion to about 1.6 million.
  • In August 2025, the company closed a $7 million private placement with existing investors, involving the sale of Series C convertible preferred stock and warrants to purchase up to 7,000,000 shares of common stock.
  • Shareholders approved an amendment to the 2022 Equity Incentive Plan in October 2025, increasing the number of shares available for awards by 2,250,000.

Inbound Investments

  • PharmaCyte closed a $7 million financing round in August 2025, which was led by existing investors through the sale of Series C convertible preferred stock and warrants.

Outbound Investments

  • In May 2024, PharmaCyte Biotech made a $7 million strategic investment in MyMD Pharmaceuticals, Inc.
  • The company increased its stake in TNF Pharmaceuticals by an additional $3 million in September 2025.
  • PharmaCyte successfully monetized its stake in Femasys Inc. by November 2025, which is expected to increase the company's cash and marketable securities to approximately $20 million from $13.3 million as of July 31, 2025.

Latest Trefis Analyses

TitleDate
0DASHBOARDS 
1PharmaCyte Biotech Earnings Notes12/16/2025
Title
0ARTICLES

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

PMCBVRTXALPSAVLNDFTXEIKNMedian
NamePharmaCy.Vertex P.ALPS Avalyn P.Definium.Eikon Th. 
Mkt Price0.70446.83-27.0623.558.9623.55
Mkt Cap0.0113.5--2.60.31.4
Rev LTM012,218--000
Op Inc LTM-54,662---193-310-99
FCF LTM-53,710---145-272-75
FCF 3Y Avg-31,977---101--3
CFO LTM-54,241---145-210-75
CFO 3Y Avg-32,401---101--3

Growth & Margins

PMCBVRTXALPSAVLNDFTXEIKNMedian
NamePharmaCy.Vertex P.ALPS Avalyn P.Definium.Eikon Th. 
Rev Chg LTM-10.1%----10.1%
Rev Chg 3Y Avg-9.9%----9.9%
Rev Chg Q-7.8%----7.8%
QoQ Delta Rev Chg LTM-1.8%----1.8%
Op Inc Chg LTM-19.6%1,214.0%---69.8%--19.6%
Op Inc Chg 3Y Avg6.6%364.1%---42.7%-6.6%
Op Mgn LTM-38.2%----38.2%
Op Mgn 3Y Avg-24.1%----24.1%
QoQ Delta Op Mgn LTM-0.2%----0.2%
CFO/Rev LTM-34.7%----34.7%
CFO/Rev 3Y Avg-21.5%----21.5%
FCF/Rev LTM-30.4%----30.4%
FCF/Rev 3Y Avg-17.7%----17.7%

Valuation

PMCBVRTXALPSAVLNDFTXEIKNMedian
NamePharmaCy.Vertex P.ALPS Avalyn P.Definium.Eikon Th. 
Mkt Cap0.0113.5--2.60.31.4
P/S-9.3----9.3
P/Op Inc-1.224.4---13.2-1.0-1.1
P/EBIT-1.222.4---11.1-1.0-1.1
P/E-2.026.2---10.8-1.0-1.5
P/CFO-1.426.8---17.7-1.4-1.4
Total Yield-50.6%3.8%---9.3%-98.0%-29.9%
Dividend Yield0.0%0.0%--0.0%0.0%0.0%
FCF Yield 3Y Avg-34.6%1.8%-----16.4%
D/E0.00.0--0.00.80.0
Net D/E-3.2-0.0---0.1-0.9-0.5

Returns

PMCBVRTXALPSAVLNDFTXEIKNMedian
NamePharmaCy.Vertex P.ALPS Avalyn P.Definium.Eikon Th. 
1M Rtn-9.1%4.5%--2.3%0.6%-10.1%-2.3%
3M Rtn-7.0%-2.2%--8.2%33.4%-37.7%-7.0%
6M Rtn-42.6%-1.9%--8.2%74.3%-40.3%-8.2%
12M Rtn-37.2%0.7%--8.2%74.3%-40.3%-8.2%
3Y Rtn-78.0%35.2%--8.2%74.3%-40.3%-8.2%
1M Excs Rtn-9.3%4.2%--2.6%0.3%-10.4%-2.6%
3M Excs Rtn-16.6%-11.7%--17.8%23.8%-47.2%-16.6%
6M Excs Rtn-18.6%-11.3%--16.0%66.5%-48.1%-16.0%
12M Excs Rtn-59.4%-23.4%--31.9%50.7%-63.9%-31.9%
3Y Excs Rtn-154.4%-38.6%--84.9%-2.3%-116.9%-84.9%

Comparison Analyses

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FDA Approved Drugs Data

Expand for More
Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA217003  IMBRUVICAibrutinibsuspension824202216.7%12.5%-9.9%-36.9%-73.4%
NDA214200  COSELAtrilaciclib dihydrochloridepowder21220210.0%13,525.0%8,775.0%12,191.7%2,816.7%
ANDA210704  ETODOLACetodolactablet121620200.0%0.0%10,858.3%12,150.0%2,816.7%
NDA208171  MONOFERRICferric derisomaltosesolution1162020-38.5%-50.0%-50.0%4,941.7%1,358.3%
NDA210563  IMBRUVICAibrutinibtablet2162018-81.5%-81.5%-80.4%-79.1%169.2%
NDA022018  LAMIVUDINE AND ZIDOVUDINElamivudinetablet31720170.0%0.0%-80.8%-80.4%169.2%
NDA205552  IMBRUVICAibrutinibcapsule21220140.0%100.8%100.8%100.8%440.5%
ANDA091588  MONTELUKAST SODIUMmontelukast sodiumtablet, chewable8032012-30.0%-44.0%242.0%420.0%1,300.0%
ANDA040843  METHOTREXATE SODIUM PRESERVATIVE FREEmethotrexate sodiuminjectable1082010-70.0%-72.7%-43.3%43.3%2,233.3%
ANDA077733  TOPIRAMATEtopiramatetablet3272009-45.9%-36.2%-80.1%-57.1%1,012.9%
...         

Financials

Segment Financials

Assets by Segment
$ Mil20252024202320222021
Business of research and development activities related to developing cellular cancer therapies60739176
Total60739176


Price Behavior

Price Behavior
Market Price$0.70 
Market Cap ($ Bil)0.0 
First Trading Date02/23/2007 
Distance from 52W High-42.6% 
   50 Days200 Days
DMA Price$0.75$0.84
DMA Trenddownup
Distance from DMA-6.4%-16.4%
 3M1YR
Volatility86.9%101.4%
Downside Capture163.68184.58
Upside Capture79.4778.26
Correlation (SPY)11.5%14.8%
PMCB Betas & Captures as of 5/31/2026

 1M2M3M6M1Y3Y
Beta5.242.340.711.391.290.75
Up Beta4.450.880.27-1.03-0.140.18
Down Beta13.5010.060.541.142.201.08
Up Capture370%210%121%285%104%25%
Bmk +ve Days13283667141432
Stock +ve Days11223261110325
Down Capture416%312%78%208%149%107%
Bmk -ve Days7132757109318
Stock -ve Days9193060124373

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PMCB
PMCB-33.6%101.4%0.01-
Sector ETF (XLV)16.9%15.0%0.8310.3%
Equity (SPY)25.3%12.1%1.5715.1%
Gold (GLD)27.6%26.9%0.881.1%
Commodities (DBC)36.9%19.0%1.523.2%
Real Estate (VNQ)12.5%13.3%0.631.5%
Bitcoin (BTCUSD)-39.7%42.2%-1.0810.9%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PMCB
PMCB-24.9%114.4%0.12-
Sector ETF (XLV)6.1%14.7%0.232.9%
Equity (SPY)13.5%17.1%0.627.4%
Gold (GLD)17.3%18.1%0.780.8%
Commodities (DBC)9.5%19.4%0.380.1%
Real Estate (VNQ)3.2%18.8%0.073.4%
Bitcoin (BTCUSD)12.1%54.6%0.426.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with PMCB
PMCB-11.9%110.2%0.17-
Sector ETF (XLV)9.9%16.6%0.481.6%
Equity (SPY)15.3%17.9%0.735.2%
Gold (GLD)13.0%16.0%0.670.5%
Commodities (DBC)7.1%18.0%0.32-0.3%
Real Estate (VNQ)5.6%20.7%0.242.0%
Bitcoin (BTCUSD)63.9%66.9%1.035.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date5152026
Short Interest: Shares Quantity0.5 Mil
Short Interest: % Change Since 4302026356.3%
Average Daily Volume0.4 Mil
Days-to-Cover Short Interest1.2 days
Basic Shares Quantity9.3 Mil
Short % of Basic Shares5.1%

Earnings Returns History

Updated 6/2/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
7/11/20221.7%0.4%8.9%
SUMMARY STATS   
# Positive111
# Negative000
Median Positive1.7%0.4%8.9%
Median Negative   
Max Positive1.7%0.4%8.9%
Max Negative   

SEC Filings

Expand for More
Report DateFiling DateFiling
01/31/202603/17/202610-Q
10/31/202512/18/202510-Q
07/31/202509/15/202510-Q
04/30/202508/11/202510-K
01/31/202503/17/202510-Q
10/31/202412/13/202410-Q
07/31/202409/17/202410-Q
04/30/202408/13/202410-K
01/31/202403/18/202410-Q
10/31/202312/15/202310-Q
07/31/202309/18/202310-Q
04/30/202307/31/202310-K
01/31/202303/16/202310-Q
10/31/202212/14/202210-Q
07/31/202209/14/202210-Q
04/30/202207/28/202210-K

Insider Activity

Updated 4/26/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Silverman, JoshuaCEO and PresidentDirectBuy10720260.8340,00033,316346,695Form
2Schechter, JonathanDirectBuy10720260.8420,00016,872162,393Form
3Silverman, JoshuaCEO and PresidentDirectBuy10720260.7930,00023,667296,824Form
4Schechter, JonathanDirectBuy10720260.7920,00015,808136,344Form
5Silverman, JoshuaCEO and PresidentDirectBuy10720260.7830,00023,493271,148Form
Core Cache Last Updated: 6/5/2026