Tearsheet

N2OFF (NITO)


Market Price (12/4/2025): $3.07 | Market Cap: $2.2 Mil
Sector: Materials | Industry: Fertilizers & Agricultural Chemicals

N2OFF (NITO)


Market Price (12/4/2025): $3.07
Market Cap: $2.2 Mil
Sector: Materials
Industry: Fertilizers & Agricultural Chemicals

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -1649%
Weak multi-year price returns
2Y Excs Rtn is -146%, 3Y Excs Rtn is -172%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -6.0 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2789%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 30%
  Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -6.0%, Rev Chg QQuarterly Revenue Change % is null
2 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Nitric Oxide Based Therapies, Biopharmaceutical R&D, Show more.
  Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1261%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1261%
3   Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 87%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -5714%
5   High stock price volatility
Vol 12M is 3689%
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -1649%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 30%
2 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, and Precision Medicine. Themes include Nitric Oxide Based Therapies, Biopharmaceutical R&D, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -146%, 3Y Excs Rtn is -172%
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -6.0 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -2789%
5 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -6.0%, Rev Chg QQuarterly Revenue Change % is null
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1261%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1261%
7 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 87%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -5714%
9 High stock price volatility
Vol 12M is 3689%

Valuation, Metrics & Events

NITO Stock


Why The Stock Moved


Qualitative Assessment

AI Generated Analysis | Feedback

Here are five key points explaining the stock movement of N2OFF (NITO) for the approximate time period from August 31, 2025, to December 4, 2025: 1. A 1-for-35 reverse stock split became effective on September 22, 2025, enacted to help N2OFF regain compliance with Nasdaq's minimum bid price requirement. This action, while intended to increase the per-share price, often signals underlying financial instability and can be perceived negatively by investors, leading to further stock depreciation.

2. N2OFF underwent a significant business transformation by completing the acquisition of MitoCareX, shifting its primary focus from cleantech to cancer drug discovery. This change, approved by shareholders on September 25, 2025, and finalized by October 2025, introduced new operational and market risks associated with the highly volatile biotech sector, which can deter certain investors.

Show more

Stock Movement Drivers

Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
NITO Return3%226%-81%-62%-88%-64%-99%
Peers Return6%49%6%-22%-3%-1%27%
S&P 500 Return16%27%-19%24%23%16%112%

Monthly Win Rates [3]
NITO Win Rate58%42%33%33%17%30% 
Peers Win Rate53%60%55%40%52%52% 
S&P 500 Win Rate58%75%42%67%75%70% 

Max Drawdowns [4]
NITO Max Drawdown-64%0%-81%-67%-92%-98% 
Peers Max Drawdown-49%-6%-13%-36%-17%-19% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: CF, FMC, IPI, CTVA, NTR.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 12/3/2025 (YTD)

How Low Can It Go

Unique KeyEventNITOS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-98.9%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven9391.5%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-85.7%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven597.7%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven182 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-83.3%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven500.0%24.7%
2018 CorrectionTime to BreakevenTime to Breakeven700 days120 days

Compare to CF, FMC, IPI, CTVA, NTR


In The Past

N2OFF's stock fell -98.9% during the 2022 Inflation Shock from a high on 3/3/2021. A -98.9% loss requires a 9391.5% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About N2OFF (NITO)

Better Bets than N2OFF (NITO)

Latest Trefis Analyses

Title
0ARTICLES

Trade Ideas

Select past ideas related to NITO. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
DD_11212025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11212025DDDuPont de NemoursDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.1%3.1%-0.2%
CF_11212025_Monopoly_xInd_xCD_Getting_Cheaper11212025CFCF IndustriesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.5%0.5%-1.1%
HL_11212025_Quality_Momentum_RoomToRun_10%11212025HLHecla MiningQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
30.9%30.9%0.0%
CDE_11072025_Dip_Buyer_ValueBuy11072025CDECoeur MiningDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
12.7%12.7%-5.7%
ATR_10312025_Dip_Buyer_ValueBuy10312025ATRAptarGroupDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
4.8%4.8%-2.5%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
DD_11212025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG11212025DDDuPont de NemoursDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.1%3.1%-0.2%
CF_11212025_Monopoly_xInd_xCD_Getting_Cheaper11212025CFCF IndustriesMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
0.5%0.5%-1.1%
HL_11212025_Quality_Momentum_RoomToRun_10%11212025HLHecla MiningQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
30.9%30.9%0.0%
CDE_11072025_Dip_Buyer_ValueBuy11072025CDECoeur MiningDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
12.7%12.7%-5.7%
ATR_10312025_Dip_Buyer_ValueBuy10312025ATRAptarGroupDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
4.8%4.8%-2.5%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for N2OFF

Peers to compare with:

Financials

NITOCFFMCIPICTVANTRMedian
NameN2OFF CF Indus.FMC Intrepid.Corteva Nutrien  
Mkt Price3.0979.2913.6025.8065.3060.0742.94
Mkt Cap0.012.81.70.344.329.27.2
Rev LTM06,7363,60827817,46926,6245,172
Op Inc LTM-62,09743372,7163,5781,265
FCF LTM-31,710-409282,6692,132869
FCF 3Y Avg-41,574-4091,4212,449715
CFO LTM-32,633-318543,2194,1531,344
CFO 3Y Avg-42,60962611,9904,7891,026

Growth & Margins

NITOCFFMCIPICTVANTRMedian
NameN2OFF CF Indus.FMC Intrepid.Corteva Nutrien  
Rev Chg LTM29.6%12.6%-13.4%8.9%5.0%0.3%6.9%
Rev Chg 3Y Avg-6.0%-13.5%-13.6%-6.1%0.8%-10.6%-8.3%
Rev Chg Q-100.0%21.1%-49.1%-7.5%12.6%12.3%2.4%
QoQ Delta Rev Chg LTM-7.3%4.5%-12.7%-1.5%1.7%2.5%0.1%
Op Mgn LTM-2,789.0%31.1%12.0%2.5%15.5%13.4%12.7%
Op Mgn 3Y Avg-2,716.9%33.2%15.4%1.6%13.0%13.7%13.4%
QoQ Delta Op Mgn LTM-1,057.1%1.9%-4.8%0.9%0.9%2.0%0.9%
CFO/Rev LTM-1,261.5%39.1%-8.8%19.6%18.4%15.6%17.0%
CFO/Rev 3Y Avg-1,485.8%38.5%1.2%22.3%11.6%17.0%14.3%
FCF/Rev LTM-1,261.5%25.4%-11.3%10.0%15.3%8.0%9.0%
FCF/Rev 3Y Avg-1,487.7%22.3%-1.2%3.7%8.3%8.7%6.0%

Valuation

NITOCFFMCIPICTVANTRMedian
NameN2OFF CF Indus.FMC Intrepid.Corteva Nutrien  
Mkt Cap0.012.81.70.344.329.27.2
P/S0.82.11.21.42.61.11.3
P/EBIT-0.06.51,913.81,515.218.48.813.6
P/E-0.010.5-7.9-2.028.615.85.2
P/CFO-0.15.5-13.37.314.36.96.2
Total Yield-5,709.4%11.9%-9.2%-49.0%3.7%10.1%-2.7%
Dividend Yield0.0%2.3%3.5%0.0%0.3%3.7%1.3%
FCF Yield 3Y Avg-4,370.4%10.1%-2.1%2.3%3.2%9.0%2.8%
D/E4.40.21.10.00.10.50.4
Net D/E-16.50.11.0-0.20.00.50.1

Returns

NITOCFFMCIPICTVANTRMedian
NameN2OFF CF Indus.FMC Intrepid.Corteva Nutrien  
1M Rtn-7.5%-5.5%-4.2%-1.8%5.5%10.2%-3.0%
3M Rtn-59.1%-5.9%-62.7%-12.3%-9.6%6.8%-10.9%
6M Rtn-69.3%-12.4%-66.8%-32.1%-8.0%1.5%-22.2%
12M Rtn-59.3%-13.7%-75.8%-7.0%6.4%28.4%-10.4%
3Y Rtn-98.9%-18.6%-88.6%-29.0%0.3%-14.3%-23.8%
1M Excs Rtn-7.5%-5.5%-4.1%-1.8%5.5%10.2%-3.0%
3M Excs Rtn-64.0%-10.6%-68.2%-17.3%-15.2%1.1%-16.3%
6M Excs Rtn-84.1%-27.2%-81.5%-46.8%-22.8%-13.2%-37.0%
12M Excs Rtn-70.0%-23.0%-89.2%-18.4%-7.3%20.7%-20.7%
3Y Excs Rtn-171.7%-91.4%-160.8%-99.9%-68.8%-88.0%-95.6%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date11142025
Short Interest: Shares Quantity44,051
Short Interest: % Change Since 10312025-57.1%
Average Daily Volume26,029
Days-to-Cover Short Interest1.69
Basic Shares Quantity711,110
Short % of Basic Shares6.2%

SEC Filings

Expand for More

Report DateFiling DateFiling
6302025814202510-Q 6/30/2025
3312025515202510-Q 3/31/2025
12312024331202510-K 12/31/2024
93020241114202410-Q 9/30/2024
6302024814202410-Q 6/30/2024
3312024515202410-Q 3/31/2024
12312023401202410-K 12/31/2023
93020231114202310-Q 9/30/2023
6302023814202310-Q 6/30/2023
3312023515202310-Q 3/31/2023
12312022327202310-K 12/31/2022
93020221114202210-Q 9/30/2022
6302022815202210-Q 6/30/2022
3312022516202210-Q 3/31/2022
12312021331202210-K 12/31/2021
93020211115202110-Q 9/30/2021