• A clinical-stage biopharmaceutical company like a smaller, pre-approval Biogen, but specialized in treatments for brain disorders.
• Like a pre-revenue Moderna, but developing therapies for neurological conditions instead of vaccines.

• Roluperidone (MIN-101): An investigational drug candidate for the treatment of negative symptoms in patients with schizophrenia.

Minerva Neurosciences (symbol: NERV) is a clinical-stage biopharmaceutical company focused on the research, development, and clinical testing of drug candidates for central nervous system (CNS) disorders. As of its most recent financial reports, Minerva Neurosciences does not have any approved products on the market and, therefore, does not generate revenue from product sales.

Consequently, Minerva Neurosciences does not have major customers in the traditional sense, as it does not currently sell products primarily to other companies or to individuals. Its operations are funded primarily through equity financing from institutional and individual investors, as well as potential collaboration agreements or grants, rather than through commercial product sales.

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Remy Luthringer, PhD Executive Chairman & Chief Executive Officer

Dr. Remy Luthringer has served as the Chief Executive Officer of Minerva Neurosciences, Inc. since November 2014 and was named Executive Chairman of the Board on February 5, 2018. He has been involved in the development of more than 150 active molecules for clinical trials in the central nervous system. Dr. Luthringer is an Advisor at Medicxi Ventures, a venture capital firm, and previously served as Chief Medical Officer for Index Ventures, focusing on investments in healthcare infrastructure. He was also the head of the FORENAP Institute for Research in Neurosciences and Neuropsychiatry in France and President and CEO of the Forenap Group. He holds a PhD in neurosciences and clinical pharmacology.

Frederick Ahlholm, CPA Senior Vice President, Chief Financial Officer, Principal Accounting Officer and Secretary

Mr. Frederick Ahlholm was promoted to Chief Financial Officer in October 2021. He joined Minerva as a consultant in January 2014, and subsequently held the positions of Chief Accounting Officer starting July 2014 and Senior Vice President starting May 2015. Prior to Minerva, he served as Vice President of Finance and Chief Accounting Officer for Amarin Corporation plc, where he contributed to the company's growth from a clinical-stage drug developer to a commercial enterprise.

Geoff Race, FCMA, MBA President

Mr. Race was one of the founders of Minerva, joining as a consultant in July 2010. He was promoted to President in October 2021, having previously served as Executive Vice President, Chief Financial Officer since May 2014, and Chief Business Officer since January 2016. Prior to Minerva, he served as Chief Executive Officer of Funxional Therapeutics Ltd., whose lead program was acquired by Boehringer Ingelheim in 2012. He also previously served as Chief Financial Officer at PanGenetics B.V. between 2006 and 2010, where a lead program was acquired by Abbott Laboratories in 2009. Mr. Race is a Fellow of the Chartered Institute of Management Accountants and holds an M.B.A.

Michael Davidson, M.D. Chief Medical Officer

Dr. Michael Davidson possesses extensive experience in the research and development of drugs for central nervous system diseases. He has consulted for numerous pharmaceutical and biotechnology companies and serves as a board member and reviewer for various professional organizations and neuroscience and psychiatry publications. Dr. Davidson has received the Neuroscience Award from the European College of Neuropsychopharmacology and the International College of Neuropsychopharmacology.

Joe Reilly, MS Senior Vice President, Chief Operating Officer

Mr. Joe Reilly holds a BS and MS in Finance from Boston College.

Minerva Neurosciences (NERV) Addressable Markets:

• Roluperidone (for negative symptoms in schizophrenia): There is a $2 billion untapped market in the U.S. for treating the negative symptoms of schizophrenia.
• Seltorexant (for insomnia disorder):
  • The global insomnia treatment market size was valued at approximately $4.09 billion in 2025. Another estimate places the global insomnia market at $5.523 billion in 2025.
  • The North American insomnia market was valued at $0.68 billion in 2022.
• Seltorexant (for major depressive disorder (MDD) as adjunctive treatment): The market size for Major Depressive Disorder (MDD) in the seven major markets (U.S., Germany, Spain, Italy, France, UK, and Japan) was approximately $5.6 billion in 2021.
• MIN-301 (for Parkinson's disease): null

Minerva Neurosciences (NERV) is a clinical-stage biopharmaceutical company primarily focused on developing therapies for central nervous system disorders. The company's future revenue growth over the next 2-3 years is expected to be driven by key advancements and potential commercialization of its lead product candidate, roluperidone (MIN-101).

Here are 3-5 expected drivers of future revenue growth:

1. Successful Completion of Roluperidone's Confirmatory Phase 3 Trial: The most significant driver for Minerva Neurosciences is the successful completion of its ongoing confirmatory Phase 3 clinical trial for roluperidone. This drug is being developed for the treatment of negative symptoms in patients with schizophrenia. The company has secured up to $200 million in financing, with an initial $80 million upfront, specifically to fund this trial and subsequent regulatory activities. Positive results from this trial are critical for advancing roluperidone towards potential market entry.

2. FDA Approval of Roluperidone: Following a successful confirmatory Phase 3 trial, a major revenue driver will be the resubmission of the New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) and the subsequent approval of roluperidone. There are currently no FDA-approved drugs specifically for the negative symptoms of schizophrenia, representing a significant unmet medical need and a substantial market opportunity if roluperidone gains approval.

3. Commercial Launch and Market Penetration of Roluperidone in the U.S.: If roluperidone receives FDA approval, its commercial launch and successful market penetration in the United States will be the direct source of revenue generation for Minerva Neurosciences. The company is already preparing for a potential U.S. commercial launch, indicating a strategic focus on bringing this product to market.

Share Issuance

• In October 2025, Minerva Neurosciences closed a private placement of Series A preferred stock and warrants for up to $200 million in gross proceeds, with $80 million received upfront for 80,000 Series A preferred shares.
• The Series A preferred stock is convertible into common stock at $2.11 per share, subject to stockholder approval and a 9.99% beneficial ownership cap.
• The private placement also includes Tranche A warrants, exercisable for an additional $80 million, and Tranche B warrants for $40 million, both contingent on certain milestone achievements.

Inbound Investments

• In October 2025, Minerva Neurosciences secured up to $200 million in gross proceeds through a private placement.
• This financing was led by Vivo Capital LLC, with participation from new and existing institutional investors including Janus Henderson Investors, Federated Hermes Kaufmann Funds, Farallon Capital Management, Coastlands Capital, Balyasny Asset Management, Logos Capital, BSQUARED Capital, Trails Edge Capital Partners, Ally Bridge Group, Foresite Capital, and Spruce Street Capital.
• The upfront funding from this private placement amounted to $80 million.

Capital Expenditures

• Minerva expects increased clinical and administrative costs as it advances the Phase 3 trial of roluperidone and prepares for potential U.S. commercialization.
• Research and development (R&D) expense for the nine months ended September 30, 2025, was $3.6 million, a decrease from $9.9 million for the same period in 2024.
• The primary focus of future capital allocation is to finance the confirmatory Phase 3 trial of roluperidone, prepare and resubmit its New Drug Application (NDA), and readiness for commercial launch in the U.S., if approved.