Tearsheet

Century Therapeutics (IPSC)


Market Price (4/13/2026): $2.23 | Market Cap: $194.7 Mil
Sector: Health Care | Industry: Biotechnology

Century Therapeutics (IPSC)


Market Price (4/13/2026): $2.23
Market Cap: $194.7 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37%

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 1557%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.

Weak multi-year price returns
2Y Excs Rtn is -69%, 3Y Excs Rtn is -96%

Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 12%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -10 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -9.6%

Stock price has recently run up significantly
6M Rtn6 month market price return is 296%, 12M Rtn12 month market price return is 369%

Weak revenue growth
Rev Chg QQuarterly Revenue Change % is null

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -95%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -96%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 374%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -9.0%

Key risks
IPSC key risks include [1] a critical dependence on the successful clinical advancement and commercialization of its lead candidates, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -37%
1 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 1557%
2 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Gene Editing & Therapy, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -69%, 3Y Excs Rtn is -96%
4 Meaningful short interest
Short Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 12%
5 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -10 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -9.6%
6 Stock price has recently run up significantly
6M Rtn6 month market price return is 296%, 12M Rtn12 month market price return is 369%
7 Weak revenue growth
Rev Chg QQuarterly Revenue Change % is null
8 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -95%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -96%
9 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 374%
10 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -9.0%
11 Key risks
IPSC key risks include [1] a critical dependence on the successful clinical advancement and commercialization of its lead candidates, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Century Therapeutics (IPSC) stock has gained about 125% since 12/31/2025 because of the following key factors:

1. Century Therapeutics completed an oversubscribed $135 million private placement in January 2026, significantly extending its cash runway into the first quarter of 2029.

2. The company announced compelling preclinical data for CNTY-813, its lead iPSC-derived beta islet cell therapy program for Type 1 Diabetes (T1D), with an Investigational New Drug (IND) submission expected in the fourth quarter of 2026 and initial clinical data anticipated in the second half of 2027.

Show more

Stock Movement Drivers

Fundamental Drivers

The 126.2% change in IPSC stock from 12/31/2025 to 4/12/2026 was primarily driven by a 137.1% change in the company's P/S Multiple.
(LTM values as of)123120254122026Change
Stock Price ($)0.992.25126.2%
Change Contribution By: 
Total Revenues ($ Mil)113109-3.7%
P/S Multiple0.81.8137.1%
Shares Outstanding (Mil)8687-0.9%
Cumulative Contribution126.2%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/12/2026
ReturnCorrelation
IPSC126.2% 
Market (SPY)-5.4%23.8%
Sector (XLV)-4.8%8.4%

Fundamental Drivers

The 351.8% change in IPSC stock from 9/30/2025 to 4/12/2026 was primarily driven by a 378.1% change in the company's P/S Multiple.
(LTM values as of)93020254122026Change
Stock Price ($)0.502.25351.8%
Change Contribution By: 
Total Revenues ($ Mil)114109-4.3%
P/S Multiple0.41.8378.1%
Shares Outstanding (Mil)8687-1.2%
Cumulative Contribution351.8%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/12/2026
ReturnCorrelation
IPSC351.8% 
Market (SPY)-2.9%28.2%
Sector (XLV)6.3%5.8%

Fundamental Drivers

The 372.7% change in IPSC stock from 3/31/2025 to 4/12/2026 was primarily driven by a 1556.5% change in the company's Total Revenues ($ Mil).
(LTM values as of)33120254122026Change
Stock Price ($)0.482.25372.7%
Change Contribution By: 
Total Revenues ($ Mil)71091556.5%
P/S Multiple6.21.8-70.8%
Shares Outstanding (Mil)8587-2.1%
Cumulative Contribution372.7%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2025 to 4/12/2026
ReturnCorrelation
IPSC372.7% 
Market (SPY)16.3%24.2%
Sector (XLV)2.3%18.8%

Fundamental Drivers

The -35.2% change in IPSC stock from 3/31/2023 to 4/12/2026 was primarily driven by a -95.4% change in the company's P/S Multiple.
(LTM values as of)33120234122026Change
Stock Price ($)3.472.25-35.2%
Change Contribution By: 
Total Revenues ($ Mil)51091999.7%
P/S Multiple38.91.8-95.4%
Shares Outstanding (Mil)5887-33.2%
Cumulative Contribution-35.2%

LTM = Last Twelve Months as of date shown

Market Drivers

3/31/2023 to 4/12/2026
ReturnCorrelation
IPSC-35.2% 
Market (SPY)63.3%24.5%
Sector (XLV)19.1%22.9%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
IPSC Return-31%-68%-35%-70%-2%127%-90%
Peers Return-7%32%41%-1%2%5%82%
S&P 500 Return27%-19%24%23%16%-0%82%

Monthly Win Rates [3]
IPSC Win Rate29%25%17%33%42%50% 
Peers Win Rate42%67%58%50%67%45% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
IPSC Max Drawdown-39%-69%-75%-70%-61%-10% 
Peers Max Drawdown-25%0%-2%-3%-23%-12% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: VRTX, ALPS, DFTX, EIKN, GENB.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/10/2026 (YTD)

How Low Can It Go

Unique KeyEventIPSCS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-96.0%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven2394.5%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days

Compare to VRTX, ALPS, DFTX, EIKN, GENB

In The Past

Century Therapeutics's stock fell -96.0% during the 2022 Inflation Shock from a high on 8/13/2021. A -96.0% loss requires a 2394.5% gain to breakeven.

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About Century Therapeutics (IPSC)

Century Therapeutics, Inc., a biotechnology company, develops transformative allogeneic cell therapies for the treatment of solid tumor and hematological malignancies. The company's lead product candidate is CNTY-101, an allogeneic, induced pluripotent stem cells (iPSCs)-derived chimeric antigen receptors (CAR)-iNK cell therapy targeting CD19 for relapsed, refractory B-cell lymphoma. It is also developing CNTY-103, a CAR-iNK candidate targeting CD133 + EGFR for recurrent glioblastoma; CNTY-102, a CAR-iT targeting CD19 + CD79b for relapsed, refractory B-cell lymphoma and other B-cell malignancies; CNTY-104, a CAR-iT or CAR-iNK multi-specific candidate for acute myeloid leukemia; and CNTY-106, a CAR-iNK or CAR-iT multi-specific candidate for multiple myeloma. Century Therapeutics, Inc. was founded in 2018 and is headquartered in Philadelphia, Pennsylvania.

AI Analysis | Feedback

Here are 1-3 brief analogies for Century Therapeutics (IPSC):

  • Like a more advanced version of CAR-T cell therapy companies such as Novartis or Gilead, but focusing on creating universal, 'off-the-shelf' treatments instead of patient-specific ones.
  • Like a Moderna or BioNTech for cancer cell therapies, leveraging a cutting-edge iPSC platform to develop multiple 'off-the-shelf' treatments.

AI Analysis | Feedback

  • CNTY-101: An allogeneic iPSC-derived CAR-iNK cell therapy targeting CD19 for relapsed, refractory B-cell lymphoma.
  • CNTY-103: A CAR-iNK candidate targeting CD133 + EGFR for recurrent glioblastoma.
  • CNTY-102: A CAR-iT candidate targeting CD19 + CD79b for relapsed, refractory B-cell lymphoma and other B-cell malignancies.
  • CNTY-104: A multi-specific CAR-iT or CAR-iNK candidate being developed for acute myeloid leukemia.
  • CNTY-106: A multi-specific CAR-iNK or CAR-iT candidate being developed for multiple myeloma.

AI Analysis | Feedback

Based on the provided company description, Century Therapeutics, Inc. (IPSC) is a biotechnology company primarily focused on the research and development of transformative allogeneic cell therapies for various cancers. The company's pipeline consists of several "product candidates" (such as CNTY-101, CNTY-103, CNTY-102, CNTY-104, and CNTY-106) that are in different stages of development, including clinical trials.

As a company primarily engaged in the development of future therapies, Century Therapeutics does not currently have major customers in the traditional sense, as its products have not yet received regulatory approval and are not commercially available for sale to other companies or individual patients. Therefore, at this stage, it does not sell primarily to other companies or directly to individuals.

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Brent Pfeiffenberger, PharmD, MBA President and Chief Executive Officer

Brent Pfeiffenberger was appointed President and Chief Executive Officer of Century Therapeutics, effective December 4, 2023. Prior to joining Century, he served as Chief Operating Officer of Neogene Therapeutics. He played a central role in driving Neogene's evolution from a preclinical company to a global, clinical-stage organization, ultimately culminating in its acquisition by AstraZeneca in 2023. Before Neogene, Dr. Pfeiffenberger spent nearly two decades in leadership roles of increasing responsibility at Bristol Myers Squibb, most recently as Senior Vice President, Head of U.S. Oncology, where he oversaw business operations for a multi-billion dollar franchise. He also held several critical global leadership positions where he built, led, and expanded commercial and business operations.

Morgan Conn, PhD Chief Financial Officer

Morgan Conn was appointed Chief Financial Officer of Century Therapeutics, effective October 14, 2024. He brings over 20 years of financing and business development leadership experience in biopharma. Most recently, he served as Chief Business Officer at Pharvaris, where his responsibilities included finance operations, corporate development, capital and corporate strategy, and investor relations.

Chad Cowan, PhD Chief Scientific Officer

Chad Cowan was appointed Chief Scientific Officer of Century Therapeutics, effective October 1, 2024. Prior to joining Century, Dr. Cowan was the founder and Chief Executive Officer of Clade Therapeutics, a privately-held cell therapy company focused on iPSC-derived αβ T cell programs and technology, which was acquired by Century in April 2024. He was also a scientific founder of CRISPR Therapeutics and a founder and Chief Scientific Officer of Sana Biotechnology. Earlier, he was a member of the Broad Institute and a principal faculty member of the Harvard Stem Cell Institute, where he directed the Diabetes Disease Program and the iPS Cell Core Facility.

Greg Russotti, PhD Chief Technology and Manufacturing Officer

Greg Russotti currently serves as Chief Technology and Manufacturing Officer at Century Therapeutics, a role he assumed in December 2023. He previously served as interim Chief Executive Officer from April 2023 to December 2023 and as Chief Technology Officer since January 2020. Before joining Century, Dr. Russotti was Vice President of Cell Therapy Development and Operations at Celgene. At Celgene, he guided chemistry, manufacturing, and controls efforts for five different cell therapy products to clinical-stage development. He was also a leader in establishing in-house clinical manufacturing at Celgene and in building Celgene's first commercial CAR T manufacturing facility. Prior to Celgene, Dr. Russotti spent 12 years at Merck Research Laboratories.

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Key Risks to Century Therapeutics (IPSC)

  1. Clinical Development and Regulatory Approval Risk: As a biotechnology company with all product candidates in development, Century Therapeutics faces significant risks related to the success of its clinical trials and the ability to obtain regulatory approvals. The failure of any lead product candidate, particularly CNTY-101, to demonstrate safety and efficacy in clinical trials, or to meet regulatory requirements, would have a material adverse impact on the company. The development of novel allogeneic, iPSC-derived cell therapies involves complex biological processes and presents unique challenges that can lead to unexpected delays or setbacks in clinical progression and regulatory pathways.
  2. Intense Competition and Market Adoption: Century Therapeutics operates in a highly competitive landscape for oncology treatments, specifically in the rapidly evolving field of cell therapies for solid tumors and hematological malignancies. Other pharmaceutical and biotechnology companies, including larger, well-established players, are developing or have already commercialized CAR-T and other cell therapies. Even if its product candidates are clinically successful, Century Therapeutics will need to compete effectively based on factors such as efficacy, safety, manufacturing capabilities, and cost. Furthermore, market adoption and favorable reimbursement policies for its novel iPSC-derived therapies are critical and uncertain.
  3. Manufacturing Complexity and Technology-Specific Challenges: The development and commercialization of allogeneic iPSC-derived cell therapies involve complex manufacturing processes that are difficult to scale, costly, and require specialized expertise and facilities. Any issues related to manufacturing consistency, quality control, or supply chain logistics could significantly delay product development or commercialization. Additionally, as a relatively nascent technology, the long-term safety, immunogenicity, and potential for tumorigenicity associated with iPSC-derived cells, while being actively researched and mitigated, represent inherent technological risks that could impact regulatory approval or market acceptance.

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Century Therapeutics' product pipeline targets several significant addressable markets:

  • For relapsed, refractory B-cell lymphoma (CNTY-101 and CNTY-102): The global B-cell lymphoma market size was valued at approximately USD 5.08 billion in 2024 and is projected to reach USD 10 billion by 2034. The U.S. B-cell lymphoma market size was approximately USD 1.39 billion in 2024 and is projected to reach USD 2.78 billion by 2034. More specifically, the market for Relapsed or Refractory Diffuse Large B-cell Lymphoma (R/r DLBCL) is estimated at USD 1.61 billion in 2025 and is expected to reach USD 2.16 billion by 2032. North America is estimated to hold a dominant position in the R/r DLBCL market, with 39.1% of the market share in 2025.

  • For recurrent glioblastoma (CNTY-103): The global glioblastoma multiforme treatment market was valued at USD 3.6 billion in 2024 and is expected to grow to USD 8.3 billion in 2034. Another report indicates a global market size of USD 4.04 billion in 2025, projected to reach USD 7.87 billion by 2033. The U.S. glioblastoma multiforme treatment market accounted for USD 1.4 billion in 2024.

  • For acute myeloid leukemia (CNTY-104): The global acute myeloid leukemia treatment market size was estimated at USD 3.47 billion in 2024 and is projected to reach USD 6.29 billion by 2030. Other projections estimate the global market at USD 3.91 billion in 2025, projected to reach USD 9.79 billion by 2034. North America dominated the global market with a revenue share of 37.6% in 2024. The U.S. acute myeloid leukemia treatment market accounted for 90.9% of the North American market in 2024.

  • For multiple myeloma (CNTY-106): The global multiple myeloma market size was valued at USD 29.24 billion in 2025 and is projected to grow to USD 44.19 billion by 2034. Another source estimates the global market at USD 27.75 billion in 2024, anticipated to reach USD 49.89 billion by 2034. North America dominated the multiple myeloma market with a market share of 58.28% in 2025. The total multiple myeloma market size in the U.S. was around USD 14,300 million in 2023.

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AI Analysis | Feedback

Century Therapeutics (NASDAQ: IPSC) is a biotechnology company focused on developing allogeneic induced pluripotent stem cells (iPSC)-derived cell therapies for autoimmune diseases and cancer. While the company is in a pre-revenue stage regarding product sales, its future revenue growth over the next 2-3 years is primarily expected to be driven by milestone payments from collaborations and the advancement of its key pipeline candidates. Here are 3-5 expected drivers of future revenue growth for Century Therapeutics: * Advancement and Positive Clinical Data for CNTY-101 in Autoimmune Diseases: The progression of CNTY-101, an iPSC-derived CAR-iNK cell therapy, in clinical trials for autoimmune diseases, particularly systemic lupus erythematosus (SLE), is a significant driver. Initial clinical data from the Phase 1 CALiPSO-1 trial for CNTY-101 in B-cell-mediated autoimmune diseases is anticipated by the end of 2025. Positive results from these trials could trigger milestone payments from current or future collaborators and enhance the company's attractiveness for new partnerships. * Progress of CNTY-813 for Type 1 Diabetes: CNTY-813, a beta islet cell therapy program aiming for a functional cure for type 1 diabetes, is a high-priority program for Century Therapeutics. The planned submission of an Investigational New Drug (IND) application in the fourth quarter of 2026 and the anticipation of initial clinical data in the second half of 2027 represent critical milestones. Successful advancement through these stages could lead to significant collaboration revenue through milestone payments. * Clinical Entry of CNTY-308 for B-cell-Mediated Diseases: CNTY-308, a CD19-targeted CAR-iT cell therapy, is on track to enter the clinic in 2026. The initiation of clinical trials for this candidate is a key development that can attract new collaborations or unlock milestone payments from existing agreements, thereby contributing to future revenue. * New Strategic Collaborations and Licensing Agreements: While a substantial collaboration revenue in 2025 was described as a "one-time event" related to a Bristol-Myers Squibb agreement, Century Therapeutics continues to rely on external funding and partnerships. The successful progression of its pipeline programs is expected to position the company for new strategic collaborations or the expansion of existing ones. These agreements typically include upfront payments, development milestone payments, and potential licensing fees, which would be crucial revenue drivers in the coming years.

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Capital Allocation Decisions for Century Therapeutics (IPSC)


Share Issuance

  • Century Therapeutics launched in July 2019 with $250 million in initial financing commitments, which represented a significant share issuance to its founding investors.
  • In March 2021, the company completed a $160 million Series C financing round.
  • Century Therapeutics completed an oversubscribed $135 million private placement, which was reported in March 2026 to have extended its cash runway into the first quarter of 2029.

Inbound Investments

  • Upon emerging from stealth mode in July 2019, Century Therapeutics secured $250 million in initial financing commitments from key partners, including Bayer, Versant Ventures, and Fujifilm Cellular Dynamics Inc. (FCDI).
  • In March 2021, the company raised $160 million through a Series C financing round, led by Casdin Capital and involving a syndicate of twelve investors.
  • A recent oversubscribed private placement brought in $135 million, extending Century Therapeutics' cash runway into the first quarter of 2029.

Outbound Investments

  • In April 2024, Century Therapeutics acquired Clade Therapeutics for approximately $35 million in upfront consideration, paid in a mix of cash and stock, with a potential additional $10 million upon achieving a clinical milestone. This acquisition was intended to enhance Century's iPSC platform and expand its pipeline.
  • In June 2020, Century Therapeutics acquired Empirica Therapeutics to leverage its expertise in iPSC-derived allogeneic cell therapies for glioblastoma (GBM).

Capital Expenditures

  • In the third quarter of 2025, Century Therapeutics invested $195K in capital expenditures, primarily directed towards funding long-term assets and infrastructure.
  • For the full year 2025, the company's capital expenditures amounted to $848K.

Better Bets vs. Century Therapeutics (IPSC)

Latest Trefis Analyses

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Trade Ideas

Select ideas related to IPSC.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
0.0%0.0%0.0%
CNC_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026CNCCenteneDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

IPSCVRTXALPSDFTXEIKNGENBMedian
NameCentury .Vertex P.ALPS Definium.Eikon Th.Generate. 
Mkt Price2.25436.271.0021.539.0011.4110.21
Mkt Cap0.2110.6----55.4
Rev LTM10912,001-0--109
Op Inc LTM-104,554--166---10
FCF LTM-1053,194--132---105
FCF 3Y Avg-1061,832--92---92
CFO LTM-1043,631--132---104
CFO 3Y Avg-1012,225--92---92

Growth & Margins

IPSCVRTXALPSDFTXEIKNGENBMedian
NameCentury .Vertex P.ALPS Definium.Eikon Th.Generate. 
Rev Chg LTM1,556.5%8.9%----782.7%
Rev Chg 3Y Avg564.8%10.4%----287.6%
Rev Chg Q-100.0%9.5%-----45.2%
QoQ Delta Rev Chg LTM-3.7%2.4%-----0.7%
Op Mgn LTM-9.6%37.9%----14.2%
Op Mgn 3Y Avg-2,547.0%24.7%-----1,261.2%
QoQ Delta Op Mgn LTM10.5%38.7%----24.6%
CFO/Rev LTM-95.2%30.3%-----32.4%
CFO/Rev 3Y Avg-1,906.4%20.5%-----943.0%
FCF/Rev LTM-96.1%26.6%-----34.7%
FCF/Rev 3Y Avg-2,115.7%17.0%-----1,049.3%

Valuation

IPSCVRTXALPSDFTXEIKNGENBMedian
NameCentury .Vertex P.ALPS Definium.Eikon Th.Generate. 
Mkt Cap0.2110.6----55.4
P/S1.89.2----5.5
P/EBIT-18.723.8----2.5
P/E-20.528.0----3.7
P/CFO-1.930.5----14.3
Total Yield-4.9%3.6%-----0.7%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-100.2%1.7%-----49.3%
D/E0.20.0----0.1
Net D/E-0.4-0.0-----0.2

Returns

IPSCVRTXALPSDFTXEIKNGENBMedian
NameCentury .Vertex P.ALPS Definium.Eikon Th.Generate. 
1M Rtn-3.8%-7.0%-2.0%19.2%-21.5%-12.8%-5.4%
3M Rtn16.0%-5.9%1.8%55.6%-40.0%-9.8%-2.1%
6M Rtn295.6%7.0%5.3%59.4%-40.0%-9.8%6.2%
12M Rtn368.8%-9.9%5.3%59.4%-40.0%-9.8%-2.2%
3Y Rtn-28.8%30.9%5.3%59.4%-40.0%-9.8%-2.2%
1M Excs Rtn-18.2%-12.0%2.5%15.0%-32.3%-10.9%-11.5%
3M Excs Rtn28.6%-5.6%4.1%48.0%-38.5%-8.3%-0.8%
6M Excs Rtn284.7%2.7%4.4%58.4%-40.9%-10.7%3.5%
12M Excs Rtn441.4%-44.5%-31.5%22.6%-76.8%-46.6%-38.0%
3Y Excs Rtn-95.7%-27.5%-60.9%-6.9%-106.2%-76.0%-68.5%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Single Segment725  
Total725  


Net Income by Segment
$ Mil20252024202320222021
Single Segment-127-137   
Total-127-137   


Assets by Segment
$ Mil20252024202320222021
Single Segment   437107
Total   437107


Price Behavior

Price Behavior
Market Price$2.25 
Market Cap ($ Bil)0.2 
First Trading Date06/18/2021 
Distance from 52W High-23.5% 
   50 Days200 Days
DMA Price$2.18$1.10
DMA Trendupup
Distance from DMA3.2%104.9%
 3M1YR
Volatility102.5%98.1%
Downside Capture1.900.60
Upside Capture677.17277.39
Correlation (SPY)40.0%24.7%
IPSC Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta2.052.272.932.751.261.45
Up Beta10.241.00-0.001.650.660.84
Down Beta1.060.744.274.441.401.78
Up Capture122%439%849%949%625%335%
Bmk +ve Days7162765139424
Stock +ve Days9183065119325
Down Capture157%190%77%62%115%112%
Bmk -ve Days12233358110323
Stock -ve Days12213056125405

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with IPSC
IPSC487.5%99.3%2.21-
Sector ETF (XLV)12.3%16.8%0.5216.7%
Equity (SPY)31.2%17.3%1.4723.3%
Gold (GLD)60.1%27.8%1.695.9%
Commodities (DBC)29.8%16.6%1.588.4%
Real Estate (VNQ)21.3%15.2%1.0715.0%
Bitcoin (BTCUSD)-4.3%43.7%0.0216.7%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with IPSC
IPSC-37.0%84.5%-0.20-
Sector ETF (XLV)6.3%14.6%0.2524.1%
Equity (SPY)11.1%17.0%0.5026.8%
Gold (GLD)22.1%17.8%1.026.5%
Commodities (DBC)11.8%18.8%0.521.4%
Real Estate (VNQ)3.7%18.8%0.1024.0%
Bitcoin (BTCUSD)4.3%56.5%0.3017.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with IPSC
IPSC-20.6%84.5%-0.20-
Sector ETF (XLV)9.8%16.5%0.4824.1%
Equity (SPY)13.8%17.9%0.6626.8%
Gold (GLD)14.2%15.9%0.746.5%
Commodities (DBC)8.6%17.6%0.411.4%
Real Estate (VNQ)5.1%20.7%0.2224.0%
Bitcoin (BTCUSD)67.6%66.9%1.0717.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date3312026
Short Interest: Shares Quantity10.3 Mil
Short Interest: % Change Since 315202619.3%
Average Daily Volume1.8 Mil
Days-to-Cover Short Interest5.6 days
Basic Shares Quantity87.3 Mil
Short % of Basic Shares11.8%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
3/12/2026-8.4%-15.8% 
11/13/2025-17.5%-8.2%1.5%
8/14/20252.1%-1.6%-9.6%
3/19/2025-5.7%-4.6%-6.7%
11/5/20245.6%16.7%14.3%
8/8/20244.0%-9.8%-15.6%
3/14/2024-7.2%3.1%-19.5%
11/9/2023-13.1%-18.8%48.7%
...
SUMMARY STATS   
# Positive553
# Negative101011
Median Positive4.0%3.1%14.3%
Median Negative-4.7%-6.9%-14.2%
Max Positive15.1%16.7%48.7%
Max Negative-17.5%-18.8%-30.0%

SEC Filings

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Report DateFiling DateFiling
12/31/202503/12/202610-K
09/30/202511/13/202510-Q
06/30/202508/14/202510-Q
03/31/202505/15/202510-Q
12/31/202403/19/202510-K
09/30/202411/05/202410-Q
06/30/202408/08/202410-Q
03/31/202405/09/202410-Q
12/31/202303/14/202410-K
09/30/202311/09/202310-Q
06/30/202308/09/202310-Q
03/31/202305/11/202310-Q
12/31/202203/16/202310-K
09/30/202211/10/202210-Q
06/30/202208/11/202210-Q
03/31/202205/16/202210-Q

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 3/12/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
Q1 2029 Cash Runway      

Prior: Q3 2025 Earnings Reported 11/13/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
Q4 2027 Cash Runway      

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Cowan, ChadChief Scientific OfficerDirectBuy122920250.8558,06049,252886,547Form
2Pfeiffenberger, BrentPresident and CEODirectBuy121620250.5852,00030,3521,939,629Form
3Carr, DouglasSVP Finance & OperationsDirectSell121020250.53257137215,393Form
4Russotti, GregorySee RemarksDirectSell121020250.53526280208,002Form
5Cowan, ChadChief Scientific OfficerDirectSell112420250.505,4622,736494,501Form