Tearsheet

Gyre Therapeutics (GYRE)


Market Price (10/31/2025): $7.67 | Market Cap: $683.5 Mil
Sector: Health Care | Industry: Biotechnology

Gyre Therapeutics (GYRE)


Market Price (10/31/2025): $7.67
Market Cap: $683.5 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Which of these 2 stories sounds closer for this stock?

1. Generates cash flow

The stock generated 4% or more of the share price (called cash flow yield), and shows moderate 10-15% or more growth.

2. Riding a trend

Think Tesla during the pandemic of 2020 when EVs were riding a cultural high, or Nvidia in the current AI boom, or even Figma. These companies don’t have enough yield, or, enough growth, or both - however - they are riding a trend. They have momentum. These can be more volatile - they don’t have the floor of strong cash flow


0 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -35%
Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 15
Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 73x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 735x, P/EPrice/Earnings or Price/(Net Income) is 164x
1   Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -8.4%
2   Not cash flow generative
FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1.6%
3   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3.9%
0 Valuation becoming less expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is -35%
1 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 15
2 Expensive valuation multiples
P/EBITPrice/EBIT or Price/(Operating Income) ratio is 73x, P/CFOPrice/(Cash Flow from Operations). CFO is cash before capital expenditures. is 735x, P/EPrice/Earnings or Price/(Net Income) is 164x
3 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -8.4%
4 Not cash flow generative
FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1.6%
5 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -3.9%

Market Valuation & Key Metrics

GYRE Stock


Return vs. Risk


Price Returns Compared

 202020212022202320242025Total [1]
Returns
GYRE Return-7%-86%120%4770%-53%-37%356%
Peers Return-15%-9%-6%-3%-3%-16%-43%
S&P 500 Return16%27%-19%24%23%16%110%

Monthly Win Rates [3]
GYRE Win Rate58%25%58%75%33%33% 
Peers Win Rate18%15%23%31%22%51% 
S&P 500 Win Rate58%75%42%67%75%67% 

Max Drawdowns [4]
GYRE Max Drawdown-49%-86%-61%-64%-64%-47% 
Peers Max Drawdown-20%-13%-14%-15%-30%-27% 
S&P 500 Max Drawdown-31%-1%-25%-1%-2%-15% 


[1] Cumulative total returns since the beginning of 2020
[2] Peers: VRTX, APM, BBOT, GDTC, HIND.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2025 data is for the year up to 10/30/2025 (YTD)

How Low Can It Go

Unique KeyEventGYRES&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-95.0%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven1885.0%34.1%
2022 Inflation ShockTime to BreakevenTime to Breakeven542 days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-58.9%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven143.1%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven1330 days148 days
2018 Correction2018 Correction  
2018 Correction% Loss% Loss-87.3%-19.8%
2018 Correction% Gain to Breakeven% Gain to Breakeven687.6%24.7%
2018 CorrectionTime to BreakevenTime to BreakevenNot Fully Recovered days120 days

Compare to VRTX, APM, BBOT, GDTC, HIND


In The Past

Gyre Therapeutics's stock fell -95.0% during the 2022 Inflation Shock from a high on 2/17/2021. A -95.0% loss requires a 1885.0% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth over time.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Gyre Therapeutics (GYRE)

Better Bets than Gyre Therapeutics (GYRE)

Trade Ideas

Select past ideas related to GYRE. For more, see Trefis Trade Ideas.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%
Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
ADMA_9302025_Dip_Buyer_ValueBuy09302025ADMAADMA BiologicsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
5.9%5.9%-4.6%
REGN_9302025_Dip_Buyer_ValueBuy09302025REGNRegeneron PharmaceuticalsDip BuyDB | P/E OPMDip Buy with Low PE and High Margin
Buying dips for companies with tame PE and meaningfully high operating margin
16.1%16.1%-0.8%
HAE_9262025_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG09262025HAEHaemoneticsDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.6%2.6%-0.1%
WAT_9192025_Monopoly_xInd_xCD_Getting_Cheaper09192025WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
14.2%14.2%-4.3%
ISRG_9052025_Monopoly_xInd_xCD_Getting_Cheaper09052025ISRGIntuitive SurgicalMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
15.2%15.2%-8.0%

Recent Active Movers

Recent Active Movers

More From Trefis

Peer Comparisons for Gyre Therapeutics

Financials

GYREVRTXAPMBBOTGDTCHINDMedian
NameGyre The.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Price7.65419.891.4712.002.155.586.62
Mkt Cap0.7107.8----54.2
Rev LTM10211,419-0--102
Op Inc LTM9-199--93---93
FCF LTM-23,500--60---2
FCF 3Y Avg-1,984----1,984
CFO LTM13,846--60--1
CFO 3Y Avg-2,324----2,324

Growth & Margins

GYREVRTXAPMBBOTGDTCHINDMedian
NameGyre The.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Rev Chg LTM-8.4%10.5%----1.0%
Rev Chg 3Y Avg-11.0%----11.0%
Rev Chg Q6.1%12.1%----9.1%
QoQ Delta Rev Chg LTM1.5%2.9%----2.2%
Op Mgn LTM9.1%-1.7%----3.7%
Op Mgn 3Y Avg-26.5%----26.5%
QoQ Delta Op Mgn LTM-1.2%2.0%----0.4%
CFO/Rev LTM0.9%33.7%----17.3%
CFO/Rev 3Y Avg-22.5%----22.5%
FCF/Rev LTM-1.6%30.6%----14.5%
FCF/Rev 3Y Avg-19.2%----19.2%

Valuation

GYREVRTXAPMBBOTGDTCHINDMedian
NameGyre The.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
Mkt Cap0.7107.8----54.2
P/S6.79.4----8.1
P/EBIT73.024.5----48.8
P/E163.729.6----96.7
P/CFO735.528.0----381.7
Total Yield0.6%3.4%----2.0%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-2.1%----2.1%
D/E0.00.0----0.0
Net D/E-0.1-0.0-----0.1

Returns

GYREVRTXAPMBBOTGDTCHINDMedian
NameGyre The.Vertex P.Aptorum BridgeBi.CytoMed .Vyome  
1M Rtn2.5%7.2%-27.2%3.6%8.0%7.7%5.4%
3M Rtn8.5%-8.1%-5.2%-14.4%-1.7%
6M Rtn-18.1%-15.8%59.8%--6.5%--11.2%
12M Rtn-48.0%-11.6%5.0%--3.4%--7.5%
3Y Rtn1,316.4%34.6%-76.8%---34.6%
1M Excs Rtn-0.7%2.2%-34.2%-1.9%5.3%-0.2%-0.5%
3M Excs Rtn5.7%-18.5%-2.1%-8.1%-1.8%
6M Excs Rtn-39.8%-37.6%38.0%--28.3%--32.9%
12M Excs Rtn-64.0%-29.0%-17.8%--33.2%--31.1%
3Y Excs Rtn1,124.0%-41.0%-151.9%----41.0%

Financials

Price Behavior

Short Interest

Short Interest: As Of Date10152025
Short Interest: Shares Quantity1,502,320
Short Interest: % Change Since 9302025-10.1%
Average Daily Volume100,600
Days-to-Cover Short Interest14.93
Basic Shares Quantity89,119,344
Short % of Basic Shares1.7%

Earnings Returns History

Expand for More

 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/11/20256.9%11.0%15.6%
5/9/202513.6%19.1%-5.6%
2/18/20256.0%-11.9%-28.5%
11/13/2024-9.6%-19.3%-38.9%
8/13/2024-2.5%10.2%29.2%
5/9/2024-2.7%0.4%-26.3%
2/14/20248.1%8.3%13.5%
8/14/20234.0%61.6%44.2%
...
SUMMARY STATS   
# Positive9118
# Negative10811
Median Positive4.5%8.3%14.6%
Median Negative-2.9%-9.5%-26.0%
Max Positive13.6%61.6%44.2%
Max Negative-41.8%-54.4%-63.6%

SEC Filings

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Report DateFiling DateFiling
6302025811202510-Q 6/30/2025
3312025509202510-Q 3/31/2025
12312024317202510-K 12/31/2024
93020241113202410-Q 9/30/2024
6302024813202410-Q 6/30/2024
3312024513202410-Q 3/31/2024
12312023327202410-K 12/31/2023
123120227202023DEFM14A 12/31/2022

Insider Activity

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 OwnerTitleFiling DateActionPriceSharesTransacted
Value
Value of
Held Shares
Form
0Ma SongjiangPresident5292025Sell10.282,00020,56028,852,280Form
1Ma SongjiangPresident5272025Sell10.972,00021,94030,812,799Form
2Ma SongjiangPresident5222025Sell11.252,00022,50031,644,270Form
3Ma SongjiangPresident5202025Sell11.312,00022,62031,858,279Form
4Ma SongjiangPresident5162025Sell11.302022631,875,311Form