Cytokinetics (CYTK)
Market Price (4/22/2026): $65.82 | Market Cap: $8.1 BilSector: Health Care | Industry: Biotechnology
Cytokinetics (CYTK)
Market Price (4/22/2026): $65.82Market Cap: $8.1 BilSector: Health CareIndustry: Biotechnology
Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.
Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 377% Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. | Weak multi-year price returns2Y Excs Rtn is -44% Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13% | Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -612 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -695% Expensive valuation multiplesP/SPrice/Sales ratio is 92x Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 128% Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -579%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -607% Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14% Key risksCYTK key risks include [1] the pivotal regulatory approval and commercialization of its lead drug aficamten, Show more. |
| Strong revenue growthRev Chg LTMRevenue Change % Last Twelve Months (LTM) is 377% |
| Megatrend and thematic driversMegatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more. |
| Weak multi-year price returns2Y Excs Rtn is -44% |
| Meaningful short interestShort Interest % of Basic SharesShort Interest % of Basic Shares = (Short Interest Quantity) / (Basic Shares Outstanding). A high fraction of short interest can indicate potential risk of a short squeeze. is 13% |
| Not profitable at operating income levelOp Inc LTMOperating Income, Last Twelve Months is -612 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -695% |
| Expensive valuation multiplesP/SPrice/Sales ratio is 92x |
| Significant share based compensationSBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 128% |
| Not cash flow generativeCFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -579%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -607% |
| Yield minus risk free rate is negativeERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -14% |
| Key risksCYTK key risks include [1] the pivotal regulatory approval and commercialization of its lead drug aficamten, Show more. |
Qualitative Assessment
AI Analysis | Feedback
1. Regulatory approvals and commercial launch of MYQORZO (aficamten) significantly boosted investor confidence.
Cytokinetics received U.S. FDA approval for MYQORZO, a cardiac myosin inhibitor for obstructive hypertrophic cardiomyopathy (oHCM), on December 19, 2025, and made it available in the U.S. market on January 27, 2026. This was further bolstered by European Commission approval on February 17, 2026, with a first European launch planned in Germany in Q2 2026, and China National Medical Products Administration approval on December 17, 2025.
2. Anticipation surrounding the Phase 3 ACACIA-HCM trial results for aficamten in non-obstructive HCM created positive sentiment.
Top-line results for this trial are expected in the second quarter of 2026. Analysts have highlighted this as a crucial catalyst, with the potential to materially increase the drug's fundamental and strategic value, contributing to increased price targets.
Show more
Stock Movement Drivers
Fundamental Drivers
The 3.6% change in CYTK stock from 12/31/2025 to 4/21/2026 was primarily driven by a 4.7% change in the company's P/S Multiple.| (LTM values as of) | 12312025 | 4212026 | Change |
|---|---|---|---|
| Stock Price ($) | 63.54 | 65.80 | 3.6% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 87 | 88 | 0.9% |
| P/S Multiple | 87.4 | 91.5 | 4.7% |
| Shares Outstanding (Mil) | 120 | 122 | -2.0% |
| Cumulative Contribution | 3.6% |
Market Drivers
12/31/2025 to 4/21/2026| Return | Correlation | |
|---|---|---|
| CYTK | 3.6% | |
| Market (SPY) | -5.4% | 26.4% |
| Sector (XLV) | -5.7% | 35.8% |
Fundamental Drivers
The 19.7% change in CYTK stock from 9/30/2025 to 4/21/2026 was primarily driven by a 19.5% change in the company's P/S Multiple.| (LTM values as of) | 9302025 | 4212026 | Change |
|---|---|---|---|
| Stock Price ($) | 54.96 | 65.80 | 19.7% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 86 | 88 | 2.7% |
| P/S Multiple | 76.6 | 91.5 | 19.5% |
| Shares Outstanding (Mil) | 119 | 122 | -2.5% |
| Cumulative Contribution | 19.7% |
Market Drivers
9/30/2025 to 4/21/2026| Return | Correlation | |
|---|---|---|
| CYTK | 19.7% | |
| Market (SPY) | -2.9% | 28.7% |
| Sector (XLV) | 5.3% | 30.8% |
Fundamental Drivers
The 63.7% change in CYTK stock from 3/31/2025 to 4/21/2026 was primarily driven by a 376.6% change in the company's Total Revenues ($ Mil).| (LTM values as of) | 3312025 | 4212026 | Change |
|---|---|---|---|
| Stock Price ($) | 40.19 | 65.80 | 63.7% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 18 | 88 | 376.6% |
| P/S Multiple | 257.0 | 91.5 | -64.4% |
| Shares Outstanding (Mil) | 118 | 122 | -3.5% |
| Cumulative Contribution | 63.7% |
Market Drivers
3/31/2025 to 4/21/2026| Return | Correlation | |
|---|---|---|
| CYTK | 63.7% | |
| Market (SPY) | 16.3% | 19.7% |
| Sector (XLV) | 1.3% | 30.7% |
Fundamental Drivers
The 87.0% change in CYTK stock from 3/31/2023 to 4/21/2026 was primarily driven by a 159.7% change in the company's P/S Multiple.| (LTM values as of) | 3312023 | 4212026 | Change |
|---|---|---|---|
| Stock Price ($) | 35.19 | 65.80 | 87.0% |
| Change Contribution By: | |||
| Total Revenues ($ Mil) | 95 | 88 | -6.9% |
| P/S Multiple | 35.2 | 91.5 | 159.7% |
| Shares Outstanding (Mil) | 95 | 122 | -22.7% |
| Cumulative Contribution | 87.0% |
Market Drivers
3/31/2023 to 4/21/2026| Return | Correlation | |
|---|---|---|
| CYTK | 87.0% | |
| Market (SPY) | 63.3% | 18.3% |
| Sector (XLV) | 18.0% | 23.3% |
Price Returns Compared
| 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | Total [1] | |
|---|---|---|---|---|---|---|---|
| Returns | |||||||
| CYTK Return | 119% | 1% | 82% | -44% | 35% | 4% | 218% |
| Peers Return | -43% | -2% | 87% | 25% | 43% | 9% | 102% |
| S&P 500 Return | 27% | -19% | 24% | 23% | 16% | 4% | 89% |
Monthly Win Rates [3] | |||||||
| CYTK Win Rate | 58% | 58% | 58% | 25% | 58% | 50% | |
| Peers Win Rate | 40% | 55% | 47% | 48% | 58% | 55% | |
| S&P 500 Win Rate | 75% | 42% | 67% | 75% | 67% | 50% | |
Max Drawdowns [4] | |||||||
| CYTK Max Drawdown | -11% | -35% | -41% | -44% | -37% | -6% | |
| Peers Max Drawdown | -53% | -33% | -27% | -23% | -39% | -13% | |
| S&P 500 Max Drawdown | -1% | -25% | -1% | -2% | -15% | -7% | |
[1] Cumulative total returns since the beginning of 2021
[2] Peers: BMY, SRPT, BBIO, EWTX, IONS. See CYTK Returns vs. Peers.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/21/2026 (YTD)
How Low Can It Go
| Event | CYTK | S&P 500 |
|---|---|---|
| 2022 Inflation Shock | ||
| % Loss | -50.7% | -25.4% |
| % Gain to Breakeven | 102.8% | 34.1% |
| Time to Breakeven | 85 days | 464 days |
| 2020 Covid Pandemic | ||
| % Loss | -47.3% | -33.9% |
| % Gain to Breakeven | 89.8% | 51.3% |
| Time to Breakeven | 284 days | 148 days |
| 2018 Correction | ||
| % Loss | -65.2% | -19.8% |
| % Gain to Breakeven | 187.6% | 24.7% |
| Time to Breakeven | 504 days | 120 days |
| 2008 Global Financial Crisis | ||
| % Loss | -83.1% | -56.8% |
| % Gain to Breakeven | 493.1% | 131.3% |
| Time to Breakeven | 4,904 days | 1,480 days |
Compare to BMY, SRPT, BBIO, EWTX, IONS
In The Past
Cytokinetics's stock fell -50.7% during the 2022 Inflation Shock from a high on 9/9/2022. A -50.7% loss requires a 102.8% gain to breakeven.
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About Cytokinetics (CYTK)
AI Analysis | Feedback
Here are 1-2 brief analogies to describe Cytokinetics (CYTK):
A Vertex Pharmaceuticals focused on muscle function drugs.
The Gilead Sciences of muscle-targeting therapeutics.
AI Analysis | Feedback
- Omecamtiv mecarbil: A novel cardiac myosin activator in Phase III clinical trial for heart failure.
- Reldesemtiv: A skeletal muscle troponin activator in Phase III clinical trial for amyotrophic lateral sclerosis and spinal muscular atrophy.
- CK-136: A novel cardiac troponin activator in Phase I clinical trial.
- Aficamten: A novel cardiac myosin inhibitor in Phase III clinical trial for symptomatic obstructive hypertrophic cardiomyopathy.
- CK-3772271: A small molecule cardiac myosin inhibitor in Phase I clinical trial.
AI Analysis | Feedback
Cytokinetics (CYTK) is a late-stage biopharmaceutical company primarily focused on drug discovery and development. Its drug candidates are currently in various phases of clinical trials, meaning they are not yet approved for commercial sale to individuals or institutions like pharmacies and hospitals.
At this stage of its business, Cytokinetics' major "customers" or revenue-generating partners are other pharmaceutical companies with whom it forms strategic alliances for co-development, licensing, and future commercialization. Based on the provided background information, a key strategic alliance is with:
- Astellas Pharma Inc. (Symbol: ALPMY)
Astellas Pharma Inc. serves as a significant partner that contributes to Cytokinetics' funding and development efforts through strategic collaborations, which can include upfront payments, milestone payments, and potential royalties on future sales of licensed products.
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Robert I. Blum, President and Chief Executive Officer
Robert I. Blum has served as President and Chief Executive Officer of Cytokinetics and a member of its Board of Directors since 2007. He participated in the launch of company operations in 1998 and held various senior-level positions, overseeing research and development, finance, corporate development, legal, commercial operations, and business development. Prior to joining Cytokinetics, Mr. Blum held senior positions in business development and marketing at COR Therapeutics from 1991 to 1998, and earlier roles in sales, marketing, and other pharmaceutical business functions at Marion Laboratories and Syntex Corporation, starting in 1981. He previously taught a corporate finance course to graduate students at the Center for BioEntrepreneurship at the University of California, San Francisco.
Sung H. Lee, Executive Vice President, Chief Financial Officer and Principal Accounting Officer
Sung H. Lee joined Cytokinetics as Executive Vice President and Chief Financial Officer, effective May 8, 2024. He also assumed the additional responsibility of principal accounting officer. Before joining Cytokinetics, Mr. Lee served as CFO of Vir Biotechnology, Inc. for a year and held the same position at MorphoSys AG for over two years. His extensive experience includes a tenure as Executive Vice President and CFO at Sangamo Therapeutics, Inc., and a 14-year career at Gilead Sciences, Inc., where he concluded his service as Senior Vice President of Financial Planning & Analysis and Investor Relations.
Fady I. Malik, M.D., Ph.D., Executive Vice President, Research & Development
Dr. Fady I. Malik has led Research and Development at Cytokinetics since 2014 and has been with the company since its inception in 1998, participating in its launch. He recognized the potential of modulating cardiac and skeletal muscle sarcomeres and led discovery and development efforts for Cytokinetics' portfolio of muscle contractility programs. Dr. Malik is an internationally recognized cardiovascular physician-scientist, an inventor on over 20 issued patents, and has authored or co-authored more than 60 publications. He holds an appointment as a Clinical Professor of Medicine in the Cardiology Division of the University of California, San Francisco.
Andrew M. Callos, Executive Vice President and Chief Commercial Officer
Andrew M. Callos serves as the Executive Vice President and Chief Commercial Officer at Cytokinetics.
Jeffrey J. Hessekiel, Executive Vice President, Chief Legal and Administrative Officer
Jeffrey J. Hessekiel holds the position of Executive Vice President, Chief Legal and Administrative Officer at Cytokinetics.
AI Analysis | Feedback
The key risks to Cytokinetics' business are primarily centered on the commercial success of its recently approved drug, MYQORZO (aficamten), its significant financial burn rate, and the ongoing development and regulatory hurdles for its other pipeline candidates.
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Commercialization and Regulatory Challenges of MYQORZO (aficamten)
While Cytokinetics has secured regulatory approval from the FDA and European Commission for MYQORZO (aficamten) for obstructive hypertrophic cardiomyopathy (oHCM), its commercial success faces significant risks. The drug's approval comes with a Risk Evaluation and Mitigation Strategy (REMS) due to the potential risk of heart failure, and the stringency of this REMS could limit physician adoption and slow market uptake. This is particularly pertinent given its competitor, Bristol Myers Squibb's Camzyos (mavacamten), also has a REMS. Furthermore, Cytokinetics faces the challenge of commercial execution as this is its first product launch, with potential missteps in pricing, payer negotiations, and overall market acceptance.
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Substantial Financial Burn Rate and Path to Profitability
Cytokinetics is currently operating in a pre-commercial, cash-burn phase, reporting a significant net loss of $785.0 million for the full year 2025. High operating expenses, largely driven by research and development (R&D) and commercialization efforts for MYQORZO, contribute to this burn rate. Although the company holds cash reserves, its long-term financial stability is highly dependent on the successful commercial performance of MYQORZO and the effective management of its cash usage as it scales operations.
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Pipeline Dependence and Clinical/Regulatory Failures for Other Candidates
Despite the approval of MYQORZO, Cytokinetics' future growth and revenue diversification depend heavily on the success of its broader pipeline. The company has other drug candidates, such as reldesemtiv (Phase III), CK-136 (Phase I), and additional trials for aficamten (e.g., in non-obstructive HCM). The prior rejection of omecamtiv mecarbil by an FDA advisory committee, which deemed its benefits did not outweigh its risks in treating a form of heart failure, underscores the inherent clinical trial and regulatory risks in biopharmaceutical development. Delays or outright failures in clinical trials, or difficulties in securing regulatory approvals for these future candidates, remain significant risks that could impede long-term growth.
AI Analysis | Feedback
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```htmlAddressable Markets for Cytokinetics' Main Products
-
Omecamtiv mecarbil (Cardiac myosin activator for heart failure):
- The global heart failure drugs market size was valued at approximately USD 8.80 billion in 2025 and is projected to reach USD 28.29 billion by 2033, demonstrating a Compound Annual Growth Rate (CAGR) of 15.73% from 2026 to 2033.
- The U.S. heart failure drugs market size is estimated at USD 2.54 billion in 2025 and is expected to reach USD 8.03 billion by 2033, with a CAGR of 15.47% over the forecast period of 2026-2033.
-
Reldesemtiv (Skeletal muscle troponin activator for amyotrophic lateral sclerosis and spinal muscular atrophy):
- null (The Phase III clinical trial for reldesemtiv in amyotrophic lateral sclerosis was discontinued in March 2023.)
-
Aficamten (Cardiac myosin inhibitor for symptomatic obstructive hypertrophic cardiomyopathy):
- The global obstructive hypertrophic cardiomyopathy (oHCM) treatment market size was valued at USD 4.07 billion in 2024 and is expected to grow to USD 8 billion by 2035, at a CAGR of approximately 6.3% during the forecast period (2025-2035).
- The North America obstructive hypertrophic cardiomyopathy treatment market was valued at USD 1.374 billion in 2024 and is projected to rise to USD 2.844 billion by 2035.
AI Analysis | Feedback
Cytokinetics, Incorporated (CYTK) is poised for significant future revenue growth over the next 2-3 years, primarily driven by the commercialization and expansion of its lead drug candidate, aficamten, and the advancement of its heart failure pipeline.
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U.S. Commercialization of Myqorzo (aficamten) for Obstructive Hypertrophic Cardiomyopathy (oHCM): Myqorzo (aficamten), a cardiac myosin inhibitor, received FDA approval in December 2025 for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy and became available in the U.S. market in January 2026. Cytokinetics anticipates reporting product sales from Myqorzo with its first-quarter 2026 results. Initial commercial traction has shown encouraging early uptake and strong engagement from healthcare providers, with over 700 healthcare professionals (HCPs) certified within three weeks of launch.
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Global Expansion of Myqorzo (aficamten) for oHCM: Beyond the U.S., Myqorzo has also secured authorization in China and received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in the European Union. The company plans to initiate its European launch, starting with Germany, in the second quarter of 2026, further expanding its global market presence and contributing to revenue growth.
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Potential Label Expansion of Myqorzo (aficamten) to Non-Obstructive Hypertrophic Cardiomyopathy (nHCM): A significant driver of future revenue growth is the potential label expansion of aficamten to include non-obstructive hypertrophic cardiomyopathy. Topline results from the Phase 3 ACACIA-HCM trial are expected in the second quarter of 2026. A successful outcome in this trial would open a substantial new market segment for the drug, with analysts viewing it as a major catalyst for the company.
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Advancement of Omecamtiv Mecarbil in Heart Failure: Cytokinetics is continuing the confirmatory Phase 3 clinical trial, COMET-HF, for omecamtiv mecarbil, a cardiac myosin activator, in patients with symptomatic heart failure with severely reduced ejection fraction (HFrEF). Enrollment in this trial is expected to continue through 2026. While commercial sales may extend slightly beyond the immediate 2-3 year timeframe, successful progress in this late-stage trial is a crucial de-risking event that underpins significant future revenue potential and is an area of increasing appreciation by analysts.
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Share Repurchases
- Cytokinetics has not reported any share repurchases over the last 3-5 years. The company's 3-Year Share Buyback Ratio was -11.70% as of September 2025, indicating potential share issuance rather than repurchases.
Share Issuance
- Cytokinetics' shares outstanding have consistently increased over the past few years, with a 16.83% increase from 2021 to 2022, a 7.46% increase from 2022 to 2023, and a 16.01% increase from 2023 to 2024.
- In September 2025, Cytokinetics completed a convertible notes offering, bolstering its balance sheet to support commercial launches.
- In February 2026, Cytokinetics filed an S-8 registration for 750,000 common shares as part of an ESOP-related offering, with a maximum aggregate offering price of $49.23 million.
Inbound Investments
- As of December 31, 2025, Cytokinetics had approximately $1.22 billion in cash, cash equivalents, and investments, which included $100 million in proceeds from drawing on Tranche 5 of the Royalty Pharma Multi-Tranche Loan during the fourth quarter of 2025.
- The company expanded a strategic partnership with Royalty Pharma in May 2024.
- Cytokinetics' 2025 revenues included milestone payments and collaboration-related activities, such as technology transfer work linked to Bayer and regulatory milestones from a licensing agreement with Sanofi. Specifically, a $7.5 million milestone payment was received from Sanofi following the approval of Myqorzo in China.
Capital Expenditures
- Cytokinetics' capital expenditures were $49 million in 2021, $11 million in 2022, $1.42 million in 2023, $3.91 million in 2024, and $25 million in 2025.
- For 2026, the company plans to allocate funds to expand production capacity to meet global supply demands after potential drug launches.
Latest Trefis Analyses
| Title | Date | |
|---|---|---|
| DASHBOARDS | ||
| Cytokinetics Earnings Notes | 12/29/2026 | |
| How Low Can Cytokinetics Stock Really Go? | 10/17/2025 | |
| CYTK Dip Buy Analysis | 07/10/2025 | |
| Cytokinetics (CYTK) worth $5.3 Tril (up $487 Bil), more valuable than Alphabet | 02/21/2025 | |
| Cytokinetics (CYTK) worth $4.8 Tril (up $469 Bil), more valuable than Alphabet | 02/18/2025 | |
| Cytokinetics (CYTK) Operating Cash Flow Comparison | 02/17/2025 | |
| ARTICLES | ||
| Small Cap Stocks Trading At 52-Week High | 10/09/2025 | |
| Market Movers | Winners: CYTK, IONS, UTHR | Losers: UP, SOC, DNA | 09/02/2025 |
Trade Ideas
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| 03202026 | WAT | Waters | Monopoly | MY | Getting CheaperMonopoly-Like with P/S DeclineLarge cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple | -0.4% | -0.4% | -3.3% |
| 03202026 | GILD | Gilead Sciences | Quality | Q | Momentum | UpsideQuality Stocks with Momentum and UpsideBuying quality stocks with strong momentum but still having room to run | 1.6% | 1.6% | -2.2% |
Research & Analysis
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Peer Comparisons
| Peers to compare with: |
Financials
| Median | |
|---|---|
| Name | |
| Mkt Price | 62.59 |
| Mkt Cap | 10.1 |
| Rev LTM | 723 |
| Op Inc LTM | -442 |
| FCF LTM | -320 |
| FCF 3Y Avg | -412 |
| CFO LTM | -237 |
| CFO 3Y Avg | -332 |
Growth & Margins
| Median | |
|---|---|
| Name | |
| Rev Chg LTM | 33.8% |
| Rev Chg 3Y Avg | 33.9% |
| Rev Chg Q | 1.3% |
| QoQ Delta Rev Chg LTM | 0.3% |
| Op Inc Chg LTM | -0.6% |
| Op Inc Chg 3Y Avg | -14.4% |
| Op Mgn LTM | -40.5% |
| Op Mgn 3Y Avg | -50.9% |
| QoQ Delta Op Mgn LTM | -11.7% |
| CFO/Rev LTM | -28.5% |
| CFO/Rev 3Y Avg | -46.2% |
| FCF/Rev LTM | -34.5% |
| FCF/Rev 3Y Avg | -51.9% |
Valuation
| Median | |
|---|---|
| Name | |
| Mkt Cap | 10.1 |
| P/S | 12.9 |
| P/Op Inc | -15.6 |
| P/EBIT | -14.9 |
| P/E | -15.3 |
| P/CFO | -19.9 |
| Total Yield | -4.9% |
| Dividend Yield | 0.0% |
| FCF Yield 3Y Avg | -6.6% |
| D/E | 0.2 |
| Net D/E | 0.0 |
Returns
| Median | |
|---|---|
| Name | |
| 1M Rtn | 8.9% |
| 3M Rtn | 0.9% |
| 6M Rtn | 25.1% |
| 12M Rtn | 100.4% |
| 3Y Rtn | 87.1% |
| 1M Excs Rtn | 0.3% |
| 3M Excs Rtn | -3.0% |
| 6M Excs Rtn | 19.7% |
| 12M Excs Rtn | 62.1% |
| 3Y Excs Rtn | 24.9% |
FDA Approved Drugs Data
Expand for More| Post-Approval Fwd Returns | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| FDA App # | Brand Name | Generic Name | Dosage Form | FDA Approval | 3M Rtn | 6M Rtn | 1Y Rtn | 2Y Rtn | Total Rtn |
| NDA219083 | MYQORZO | aficamten | tablet | 12192025 | -1.6% | 4.9% | 4.9% | 4.9% | 4.9% |
Price Behavior
| Market Price | $65.80 | |
| Market Cap ($ Bil) | 8.1 | |
| First Trading Date | 04/30/2004 | |
| Distance from 52W High | -6.1% | |
| 50 Days | 200 Days | |
| DMA Price | $64.18 | $56.57 |
| DMA Trend | up | indeterminate |
| Distance from DMA | 2.5% | 16.3% |
| 3M | 1YR | |
| Volatility | 39.7% | 60.6% |
| Downside Capture | 0.26 | 0.32 |
| Upside Capture | 107.16 | 116.95 |
| Correlation (SPY) | 27.7% | 13.0% |
| 1M | 2M | 3M | 6M | 1Y | 3Y | |
|---|---|---|---|---|---|---|
| Beta | 1.43 | 1.24 | 0.82 | 0.98 | 0.64 | 0.90 |
| Up Beta | 0.55 | 0.27 | 0.53 | 1.01 | 0.57 | 0.62 |
| Down Beta | 1.42 | 1.91 | 0.91 | 0.27 | 0.41 | 0.64 |
| Up Capture | 241% | 133% | 102% | 177% | 113% | 175% |
| Bmk +ve Days | 7 | 16 | 27 | 65 | 139 | 424 |
| Stock +ve Days | 12 | 24 | 34 | 67 | 129 | 365 |
| Down Capture | 81% | 96% | 62% | 104% | 87% | 105% |
| Bmk -ve Days | 12 | 23 | 33 | 58 | 110 | 323 |
| Stock -ve Days | 10 | 18 | 29 | 59 | 122 | 383 |
[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CYTK | |
|---|---|---|---|---|
| CYTK | 72.0% | 60.7% | 1.11 | - |
| Sector ETF (XLV) | 9.2% | 16.0% | 0.37 | 24.7% |
| Equity (SPY) | 23.7% | 12.7% | 1.52 | 12.6% |
| Gold (GLD) | 41.4% | 27.5% | 1.25 | 15.7% |
| Commodities (DBC) | 22.4% | 16.2% | 1.25 | 3.9% |
| Real Estate (VNQ) | 14.2% | 13.8% | 0.72 | 5.2% |
| Bitcoin (BTCUSD) | -10.4% | 42.7% | -0.14 | 13.5% |
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Based On 5-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CYTK | |
|---|---|---|---|---|
| CYTK | 20.9% | 69.7% | 0.53 | - |
| Sector ETF (XLV) | 5.9% | 14.6% | 0.22 | 23.4% |
| Equity (SPY) | 10.8% | 17.1% | 0.49 | 22.9% |
| Gold (GLD) | 21.6% | 17.8% | 0.99 | 9.2% |
| Commodities (DBC) | 10.9% | 18.8% | 0.47 | 3.4% |
| Real Estate (VNQ) | 4.1% | 18.8% | 0.12 | 20.1% |
| Bitcoin (BTCUSD) | 3.8% | 56.4% | 0.29 | 11.2% |
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Based On 10-Year Data
| Annualized Return | Annualized Volatility | Sharpe Ratio | Correlation with CYTK | |
|---|---|---|---|---|
| CYTK | 23.2% | 67.7% | 0.59 | - |
| Sector ETF (XLV) | 9.5% | 16.5% | 0.47 | 28.5% |
| Equity (SPY) | 13.9% | 17.9% | 0.67 | 26.8% |
| Gold (GLD) | 13.7% | 15.9% | 0.71 | 8.2% |
| Commodities (DBC) | 8.2% | 17.6% | 0.39 | 6.6% |
| Real Estate (VNQ) | 5.4% | 20.7% | 0.23 | 20.9% |
| Bitcoin (BTCUSD) | 68.0% | 66.9% | 1.07 | 7.4% |
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Returns Analyses
Earnings Returns History
Expand for More| Forward Returns | |||
|---|---|---|---|
| Earnings Date | 1D Returns | 5D Returns | 21D Returns |
| 2/24/2026 | -10.3% | -13.4% | -11.0% |
| 11/5/2025 | 1.9% | 11.4% | 8.3% |
| 8/7/2025 | -3.2% | 9.8% | 47.8% |
| 2/27/2025 | -3.1% | -8.8% | -9.0% |
| 8/8/2024 | 3.3% | 5.7% | 3.4% |
| 5/8/2024 | -1.9% | -7.3% | -19.1% |
| 2/27/2024 | -9.8% | -18.0% | -11.8% |
| 11/2/2023 | 4.8% | -4.4% | -2.2% |
| ... | |||
| SUMMARY STATS | |||
| # Positive | 9 | 8 | 8 |
| # Negative | 10 | 11 | 11 |
| Median Positive | 3.7% | 7.7% | 11.0% |
| Median Negative | -5.3% | -6.4% | -9.0% |
| Max Positive | 10.9% | 11.4% | 47.8% |
| Max Negative | -10.3% | -18.0% | -20.6% |
SEC Filings
Expand for More| Report Date | Filing Date | Filing |
|---|---|---|
| 12/31/2025 | 02/26/2026 | 10-K |
| 09/30/2025 | 11/05/2025 | 10-Q |
| 06/30/2025 | 08/07/2025 | 10-Q |
| 03/31/2025 | 05/06/2025 | 10-Q |
| 12/31/2024 | 02/27/2025 | 10-K |
| 09/30/2024 | 11/07/2024 | 10-Q |
| 06/30/2024 | 08/09/2024 | 10-Q |
| 03/31/2024 | 05/10/2024 | 10-Q |
| 12/31/2023 | 02/28/2024 | 10-K |
| 09/30/2023 | 11/03/2023 | 10-Q |
| 06/30/2023 | 08/03/2023 | 10-Q |
| 03/31/2023 | 05/05/2023 | 10-Q |
| 12/31/2022 | 03/01/2023 | 10-K |
| 09/30/2022 | 11/04/2022 | 10-Q |
| 06/30/2022 | 08/05/2022 | 10-Q |
| 03/31/2022 | 05/06/2022 | 10-Q |
Recent Forward Guidance [BETA]
Latest: Q4 2025 Earnings Reported 2/24/2026
| Forward Guidance | Guidance Change | ||||||
|---|---|---|---|---|---|---|---|
| Metric | Low | Mid | High | % Chg | % Delta | Change | Prior |
| 2026 GAAP Combined R&D and SG&A Expense | 830.00 Mil | 850.00 Mil | 870.00 Mil | 23.2% | Higher New | Actual: 690.00 Mil for 2025 | |
| 2026 Non-cash stock-based compensation expense | 120.00 Mil | 125.00 Mil | 130.00 Mil | 8.7% | Higher New | Actual: 115.00 Mil for 2025 | |
Prior: Q3 2025 Earnings Reported 11/5/2025
| Forward Guidance | Guidance Change | ||||||
|---|---|---|---|---|---|---|---|
| Metric | Low | Mid | High | % Chg | % Delta | Change | Prior |
| 2025 GAAP operating expense | 680.00 Mil | 690.00 Mil | 700.00 Mil | 0 | Affirmed | Guidance: 690.00 Mil for 2025 | |
| 2025 Non-cash stock-based compensation expense | 110.00 Mil | 115.00 Mil | 120.00 Mil | 0 | Affirmed | Guidance: 115.00 Mil for 2025 | |
Insider Activity
Expand for More| # | Owner | Title | Holding | Action | Filing Date | Price | Shares | Transacted Value | Value of Held Shares | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Callos, Andrew | EVP, Chief Commercial Officer | Direct | Sell | 1052026 | 60.28 | 15,000 | 904,200 | 3,040,523 | Form |
| 2 | Callos, Andrew | EVP, Chief Commercial Officer | Direct | Sell | 1022026 | 62.62 | 1,798 | 112,585 | 3,158,385 | Form |
| 3 | Callos, Andrew | EVP, Chief Commercial Officer | Direct | Sell | 12302025 | 62.44 | 1,809 | 112,954 | 3,206,481 | Form |
| 4 | Wierenga, Wendell | Direct | Sell | 12232025 | 66.14 | 20,000 | 1,322,800 | 2,145,846 | Form | |
| 5 | Malik, Fady Ibraham | EVP Research & Development | Direct | Sell | 12162025 | 61.24 | 2,200 | 134,728 | 8,484,924 | Form |
Industry Resources
External Quote Links
| Y Finance | Barrons |
| TradingView | Morningstar |
| SeekingAlpha | ValueLine |
| Motley Fool | Robinhood |
| CNBC | Etrade |
| MarketWatch | Unusual Whales |
| YCharts | Perplexity Finance |
| FinViz |
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