Tearsheet

Caris Life Sciences (CAI)


Market Price (4/16/2026): $20.95 | Market Cap: $5.9 Bil
Sector: Health Care | Industry: Biotechnology

Caris Life Sciences (CAI)


Market Price (4/16/2026): $20.95
Market Cap: $5.9 Bil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 97%

Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 10%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Digital Health & Telemedicine. Themes include Personalized Diagnostics, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -99%, 3Y Excs Rtn is -134%

Key risks
CAI key risks include [1] its history of persistent net losses and high cash burn, Show more.

0 Strong revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is 97%
1 Attractive cash flow generation
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is 10%
2 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Digital Health & Telemedicine. Themes include Personalized Diagnostics, Targeted Therapies, Show more.
3 Weak multi-year price returns
2Y Excs Rtn is -99%, 3Y Excs Rtn is -134%
4 Key risks
CAI key risks include [1] its history of persistent net losses and high cash burn, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Caris Life Sciences (CAI) stock has lost about 20% since 12/31/2025 because of the following key factors:

1. Continued Net Losses Despite Strong Revenue Growth.

Despite reporting a significant 97% increase in total revenue to $812.0 million for the full year ended December 31, 2025, Caris Life Sciences still reported a net loss of $68.1 million for the same period. While the company achieved a net income of $82.0 million in Q4 2025, the overall annual unprofitability suggests that the robust top-line growth has not yet translated into sustained positive earnings, which may have contributed to investor caution.

2. Anticipated Increase in Operating Expenses for Future Investments.

Management's outlook for 2026 indicates a planned, more significant rise in operating expenses to support investment-heavy growth, particularly in scaling its early detection capacity and commercial infrastructure. While these investments are strategic for long-term growth, the expectation of higher expenses suggests continued pressure on short-term profitability, potentially dampening investor sentiment looking for immediate earnings improvements.

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Stock Movement Drivers

Fundamental Drivers

The -22.3% change in CAI stock from 12/31/2025 to 4/15/2026 was primarily driven by a -9.8% change in the company's Shares Outstanding (Mil).
(LTM values as of)123120254152026Change
Stock Price ($)26.9820.95-22.3%
Change Contribution By: 
Total Revenues ($ Mil)8120.0%
P/S Multiple7.30.0%
Shares Outstanding (Mil)255283-9.8%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2025 to 4/15/2026
ReturnCorrelation
CAI-22.3% 
Market (SPY)-5.4%37.9%
Sector (XLV)-4.5%30.5%

Fundamental Drivers

The -30.7% change in CAI stock from 9/30/2025 to 4/15/2026 was primarily driven by a -9.8% change in the company's Shares Outstanding (Mil).
(LTM values as of)93020254152026Change
Stock Price ($)30.2520.95-30.7%
Change Contribution By: 
Total Revenues ($ Mil)8120.0%
P/S Multiple7.30.0%
Shares Outstanding (Mil)255283-9.8%
Cumulative Contribution0.0%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 4/15/2026
ReturnCorrelation
CAI-30.7% 
Market (SPY)-2.9%27.1%
Sector (XLV)6.6%21.1%

Fundamental Drivers

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Market Drivers

3/31/2025 to 4/15/2026
ReturnCorrelation
CAI-62.6% 
Market (SPY)16.3%25.5%
Sector (XLV)2.6%26.8%

Fundamental Drivers

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Market Drivers

3/31/2023 to 4/15/2026
ReturnCorrelation
CAI  
Market (SPY)63.3%25.5%
Sector (XLV)19.5%26.8%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
CAI Return79%0%0%0%-52%-25%-35%
Peers Return-7%32%41%-1%2%10%91%
S&P 500 Return27%-19%24%23%16%2%85%

Monthly Win Rates [3]
CAI Win Rate67%0%0%0%25%25% 
Peers Win Rate42%67%58%50%67%53% 
S&P 500 Win Rate75%42%67%75%67%50% 

Max Drawdowns [4]
CAI Max Drawdown-3%0%0%0%-58%-38% 
Peers Max Drawdown-25%0%-2%-3%-23%-12% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: VRTX, ALPS, DFTX, EIKN, GENB.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 4/15/2026 (YTD)

How Low Can It Go

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In The Past

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Asset Allocation

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About Caris Life Sciences (CAI)

CAI International, Inc. operates as transportation finance and logistics company in the United States and internationally. It leases, re-leases, and disposes containers; and contracts for the repair, repositioning, and storage of containers. The company leases its container equipment to lessees under long-term, short-term, and finance leases to container shipping lines, freight forwarders, and other transportation companies. It also sells containers primarily to investor groups, and provides management services to those investors, as well as sells used containers. In addition, the company leases railcars consisting of box cars for paper and forest products; covered hoppers for grain, cement, sand, plastic pallets, and other industrial products; general purpose tank cars that are used to transport non-hazardous commodities; gondolas for coal; and general service flat cars. As of December 31, 2014, it had a container fleet comprised 1,175,656 cost equivalent units; and an owned fleet of 2,361 railcars in North America primarily to railroad transport companies. The company was formerly known as Container Applications International, Inc. and changed its name to CAI International, Inc. in February 2007. CAI International, Inc. was founded in 1989 and is headquartered in San Francisco, California.

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David Dean Halbert, Chairman, Founder and CEO
  • Mr. Halbert is a proven leader with over 40 years of experience across the energy, financial, and healthcare industries.
  • He founded AdvancePCS® in 1987, a pharmacy benefits management company, serving as Chairman and CEO until its sale to CareMark® in 2004 for $7.5 billion. Under his leadership, AdvancePCS grew into a publicly traded, Fortune® 250 corporation with over $15 billion in annual revenue and returned 31 times its initial public offering (IPO) value.
  • He also grew Caris Diagnostics, which was sold to Miraca Life Sciences® in 2011 for $725 million.
  • Mr. Halbert acquired Molecular Profiling Institute (MPI) in 2008, which became Caris Life Sciences.
Luke Power, Senior Vice President, Chief Financial Officer and Chief Accounting Officer
  • Mr. Power joined Caris Life Sciences in 2011 and has progressively held positions with increasing responsibility.
  • He oversees finance, accounting, and audit operations, and provides strategic financial guidance for corporate operations and functions.
  • Prior to joining Caris, Mr. Power worked within the PricewaterhouseCoopers (PWC) assurance practice in Ireland, the United States, and the United Kingdom.
  • He is a Certified Public Accountant (CPA) and a fellow of Chartered Accountants Ireland, holding a degree in finance and accounting from Waterford Institute of Technology.
David Spetzler, MS, PhD, MBA, President and Chief Scientific Officer
  • Dr. Spetzler holds a PhD in mathematics and molecular cellular biology.
George W. Sledge, Jr., MD, Executive Vice President and Chief Medical Officer
  • Dr. Sledge serves as the Executive Vice President and Chief Medical Officer for Caris Life Sciences.
Jon Mark Harmon, Chief Operations Officer
  • Mr. Harmon serves as the Chief Operations Officer for Caris Life Sciences.

AI Analysis | Feedback

The background information provided describes CAI International, Inc., a transportation finance and logistics company. However, the request specifically asks for risks related to "Caris Life Sciences (symbol: CAI)". Publicly available information confirms that Caris Life Sciences currently trades under the symbol CAI on NASDAQ. Therefore, the provided background is not consistent with the company for which risks are requested. As a precision medicine company utilizing AI and molecular profiling, Caris Life Sciences faces distinct risks compared to a transportation finance company. Key risks for Caris Life Sciences include:
  1. Competition and Market Acceptance of its Technology: Caris Life Sciences operates in the highly competitive and rapidly evolving field of precision medicine and molecular diagnostics. The company's success depends on the market acceptance and adoption of its proprietary molecular profiling platform and AI-driven solutions by healthcare providers, pharmaceutical companies, and patients. Intense competition from other diagnostic companies, large pharmaceutical firms, and academic institutions developing similar technologies could limit its growth and market share.
  2. Regulatory and Reimbursement Risks: The diagnostic and precision medicine industry is subject to extensive government regulation, including those from the FDA in the United States. Changes in regulatory requirements, delays in obtaining necessary approvals for new tests or platforms, or adverse regulatory decisions could significantly impact Caris Life Sciences' operations and product launches. Furthermore, securing adequate reimbursement from insurance providers and government programs for its advanced diagnostic tests is crucial for commercial success. Unfavorable changes in reimbursement policies or pricing pressures could negatively affect revenue and profitability.
  3. Reliance on Technology and Data Security: As an AI TechBio company, Caris Life Sciences heavily relies on its sophisticated technology, proprietary algorithms, and extensive genomic and molecular data. Risks include the potential for technological failures, cybersecurity breaches compromising sensitive patient data, or intellectual property infringement. Maintaining the integrity, security, and proprietary nature of its data and technology is paramount to its business model and competitive advantage.

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Caris Life Sciences (NASDAQ: CAI) is poised for substantial revenue growth over the next two to three years, driven by several key initiatives and market trends. The company's forward guidance and recent earnings commentaries highlight a robust strategy focused on expanding its core services, launching innovative new products, and enhancing its commercial reach.

Here are the primary expected drivers of future revenue growth for Caris Life Sciences:

  1. Expansion of Molecular Profiling Services: Caris Life Sciences anticipates continued strong growth in its molecular profiling services, particularly within its therapy selection segment. The company projects molecular profiling revenue to grow approximately 21% to 22% in 2026, or an estimated 26% to 28% excluding prior year adjustments. This growth is expected to be fueled by an approximate 20% year-over-year increase in clinical therapy selection volume. Additionally, improvements in average sales prices (ASPs) for both tissue and blood-based testing platforms are contributing to this expansion.

  2. Launch and Adoption of Caris Detect: A significant driver of future revenue is the planned launch of Caris Detect, a multi-cancer early detection (MCED) test, in the first half of 2026. This new product is considered a major market opportunity with the potential to significantly impact cancer mortality rates. Interim results from the ACHIEVE-1 study support its upcoming launch, indicating promising clinical performance.

  3. Aggressive Commercial Expansion and Sales Force Growth: To support the uptake of its existing and new products, Caris Life Sciences plans to aggressively invest in expanding its commercial organization. This includes plans to increase its sales force by approximately 20% to 25% to around 300 representatives in 2026. This strategic investment aims to drive greater adoption and market penetration of its comprehensive molecular profiling platform.

  4. Growth in Pharmaceutical Research and Development (Pharma R&D) Services: While molecular profiling remains the core, the company also expects a recovery and growth in its pharmaceutical research and development services. For 2026, Pharma R&D services revenue is expected to be in the range of $75 million to $85 million. Collaborations, such as the announced partnership with Genentech for novel therapeutic target discovery, underscore the potential in this segment.

  5. Leveraging AI TechBio Platform and Data Set: Caris Life Sciences positions itself as a next-generation AI TechBio company. Its extensive molecular data set, which has surpassed 1 million genomic profiles, serves as a valuable clinical genomic resource. This advanced platform, combining whole exome and whole transcriptome sequencing with AI and machine learning, is expected to attract more customers and strategic partnerships, fueling further growth in both its diagnostic and R&D offerings.

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Share Issuance

  • Caris Life Sciences completed its Initial Public Offering (IPO) on June 18, 2025, listing on the Nasdaq Global Select Market under the ticker symbol "CAI".
  • The company priced its IPO at $21.00 per share, selling 23,529,412 shares of common stock and raising over $494.1 million.
  • Caris Life Sciences granted the underwriters a 30-day option to purchase up to an additional 3,529,411 shares of common stock at the initial public offering price.

Inbound Investments

  • In May 2021, Caris Life Sciences received an $830 million growth equity investment, which gave the company a post-money valuation of $7.83 billion.
  • This 2021 investment round was led by Sixth Street, with significant participation from T. Rowe Price Associates Inc., Silver Lake, Fidelity Management & Research Co., and Coatue Management LLC.
  • In April 2025, Caris Life Sciences closed a $168 million growth capital funding round, led by Braidwell LP, with participation from new investors Perceptive Advisors, Woodline, and Ghisallo, among others.

Capital Expenditures

  • For the full year 2026, Caris Life Sciences anticipates capital expenditures to increase to $60 million.
  • The primary focus of these expected capital expenditures in 2026 is for early detection capacity, including the purchase of additional NovaSeq X machines for their new Assure assay and early detection initiatives.
  • As of December 31, 2025, Caris Life Sciences had over $800 million in cash on hand, providing strategic flexibility for ongoing investments in its technology platform for new products and the development of new channels like Multi-Cancer Early Detection (MCED).

Trade Ideas

Select ideas related to CAI.

Unique KeyDateTickerCompanyCategoryTrade Strategy6M Fwd Rtn12M Fwd Rtn12M Max DD
PGNY_3312026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03312026PGNYProgynyDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
0.0%0.0%0.0%
CNC_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026CNCCenteneDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
2.3%2.3%-0.6%
OSCR_3272026_Dip_Buyer_High_FCF_Yield_ExInd_DE_RevG03272026OSCROscar HealthDip BuyDB | FCF Yield | Low D/EDip Buy with High Free Cash Flow Yield
Buying dips for companies with significant free cash flow yield (FCF / Market Cap) and reasonable debt / market cap
3.0%3.0%-2.6%
WAT_3202026_Monopoly_xInd_xCD_Getting_Cheaper03202026WATWatersMonopolyMY | Getting CheaperMonopoly-Like with P/S Decline
Large cap with monopoly-like margins or cash flow generation and getting cheaper based on P/S multiple
-0.4%-0.4%-3.3%
GILD_3202026_Quality_Momentum_RoomToRun_10%03202026GILDGilead SciencesQualityQ | Momentum | UpsideQuality Stocks with Momentum and Upside
Buying quality stocks with strong momentum but still having room to run
1.6%1.6%-2.2%

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

CAIVRTXALPSDFTXEIKNGENBMedian
NameCaris Li.Vertex P.ALPS Definium.Eikon Th.Generate. 
Mkt Price20.95441.701.0022.1510.8412.5016.73
Mkt Cap7.6112.0----59.8
Rev LTM81212,001-0--812
Op Inc LTM454,554--166--45
FCF LTM673,194--132--67
FCF 3Y Avg-1,832--92--870
CFO LTM833,631--132--83
CFO 3Y Avg-2,225--92--1,067

Growth & Margins

CAIVRTXALPSDFTXEIKNGENBMedian
NameCaris Li.Vertex P.ALPS Definium.Eikon Th.Generate. 
Rev Chg LTM97.0%8.9%----52.9%
Rev Chg 3Y Avg-10.4%----10.4%
Rev Chg Q125.4%9.5%----67.5%
QoQ Delta Rev Chg LTM25.1%2.4%----13.7%
Op Mgn LTM5.6%37.9%----21.8%
Op Mgn 3Y Avg-24.7%----24.7%
QoQ Delta Op Mgn LTM17.9%38.7%----28.3%
CFO/Rev LTM10.2%30.3%----20.2%
CFO/Rev 3Y Avg-20.5%----20.5%
FCF/Rev LTM8.2%26.6%----17.4%
FCF/Rev 3Y Avg-17.0%----17.0%

Valuation

CAIVRTXALPSDFTXEIKNGENBMedian
NameCaris Li.Vertex P.ALPS Definium.Eikon Th.Generate. 
Mkt Cap7.6112.0----59.8
P/S-9.3----9.3
P/EBIT-24.1----24.1
P/E-28.3----28.3
P/CFO-30.8----30.8
Total Yield-0.9%3.5%----1.3%
Dividend Yield0.0%0.0%----0.0%
FCF Yield 3Y Avg-1.7%----1.7%
D/E-0.0----0.0
Net D/E--0.0-----0.0

Returns

CAIVRTXALPSDFTXEIKNGENBMedian
NameCaris Li.Vertex P.ALPS Definium.Eikon Th.Generate. 
1M Rtn10.0%-5.2%-9.9%20.9%-9.3%4.5%-0.4%
3M Rtn-20.7%-1.7%3.6%47.5%-27.7%-1.2%-1.5%
6M Rtn-32.8%8.3%5.3%64.0%-27.7%-1.2%2.1%
12M Rtn-62.6%-11.7%5.3%64.0%-27.7%-1.2%-6.5%
3Y Rtn-62.6%32.4%5.3%64.0%-27.7%-1.2%2.1%
1M Excs Rtn5.1%-10.1%-14.7%16.1%-14.1%-0.3%-5.2%
3M Excs Rtn-21.5%-3.7%-0.7%48.1%-28.6%-2.0%-2.9%
6M Excs Rtn-36.3%2.9%-0.2%58.4%-33.3%-6.7%-3.5%
12M Excs Rtn-93.5%-39.7%-25.6%33.0%-58.7%-32.1%-35.9%
3Y Excs Rtn-133.5%-34.3%-65.6%-7.0%-98.6%-72.1%-68.8%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil202520242023
Molecular profiling services349279239
Pharma research and development services632720
Total412306258


Price Behavior

Price Behavior
Market Price$20.95 
Market Cap ($ Bil)5.9 
First Trading Date05/16/2007 
Distance from 52W High-62.6% 
   50 Days200 Days
DMA Price$24.47$24.47
DMA Trenddowndown
Distance from DMA-14.4%-14.4%
 3M1YR
Volatility60.1%58.4%
Downside Capture0.990.84
Upside Capture124.3097.57
Correlation (SPY)36.5%14.4%
CAI Betas & Captures as of 3/31/2026

 1M2M3M6M1Y3Y
Beta2.031.951.691.190.380.20
Up Beta4.862.402.600.940.070.07
Down Beta1.641.471.381.02-0.28-0.12
Up Capture233%146%74%65%48%6%
Bmk +ve Days7162765139424
Stock +ve Days91828619090
Down Capture176%230%211%163%149%92%
Bmk -ve Days12233358110323
Stock -ve Days13243463104104

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CAI
CAI-24.7%58.6%-0.37-
Sector ETF (XLV)9.5%16.0%0.3826.8%
Equity (SPY)22.0%12.9%1.3625.5%
Gold (GLD)49.0%27.5%1.447.7%
Commodities (DBC)25.0%16.1%1.38-1.5%
Real Estate (VNQ)17.3%13.7%0.9222.5%
Bitcoin (BTCUSD)-10.4%42.6%-0.1416.1%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CAI
CAI-0.7%61.0%0.19-
Sector ETF (XLV)6.5%14.6%0.2611.0%
Equity (SPY)10.9%17.0%0.5010.5%
Gold (GLD)21.9%17.8%1.014.4%
Commodities (DBC)11.5%18.8%0.504.8%
Real Estate (VNQ)4.0%18.8%0.126.8%
Bitcoin (BTCUSD)5.1%56.5%0.312.0%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with CAI
CAI17.2%58.6%0.67-
Sector ETF (XLV)9.5%16.5%0.4727.6%
Equity (SPY)13.8%17.9%0.6735.3%
Gold (GLD)14.3%15.9%0.75-1.9%
Commodities (DBC)8.7%17.6%0.4119.6%
Real Estate (VNQ)5.4%20.7%0.2227.1%
Bitcoin (BTCUSD)67.8%66.9%1.0710.4%

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Short Interest

Short Interest: As Of Date3312026
Short Interest: Shares Quantity10.3 Mil
Short Interest: % Change Since 315202636.4%
Average Daily Volume3.2 Mil
Days-to-Cover Short Interest3.2 days
Basic Shares Quantity282.5 Mil
Short % of Basic Shares3.6%

Earnings Returns History

Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
2/26/20264.7%-0.1%-11.9%
11/5/2025-15.7%-15.2%-2.9%
8/12/20255.6%13.8%5.4%
SUMMARY STATS   
# Positive211
# Negative122
Median Positive5.1%13.8%5.4%
Median Negative-15.7%-7.7%-7.4%
Max Positive5.6%13.8%5.4%
Max Negative-15.7%-15.2%-11.9%

SEC Filings

Expand for More
Report DateFiling DateFiling
12/31/202503/03/202610-K
09/30/202511/05/202510-Q
06/30/202508/12/202510-Q
03/31/202506/20/2025424B4
12/31/202312/20/2024DRS/A

Recent Forward Guidance [BETA]

Latest: Q4 2025 Earnings Reported 2/26/2026

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2026 Revenue1.00 Bil1.01 Bil1.02 Bil39.3% Higher NewActual: 725.00 Mil for 2025
2026 Revenue Growth23.0%24.5%26.0%-67.8%-51.5%Lower NewActual: 76.0% for 2025
2026 Clinical therapy selection volume growth 20.0% -7.0%-1.5%Lower NewActual: 21.5% for 2025
2026 Molecular profiling revenue growth21.0%21.5%22.0%   
2026 Pharma & research revenue75.00 Mil80.00 Mil85.00 Mil   
2026 Operating Expenses590.00 Mil592.50 Mil595.00 Mil   

Prior: Q3 2025 Earnings Reported 11/5/2025

Forward GuidanceGuidance Change
MetricLowMidHigh% Chg% DeltaChangePrior
2025 Revenue720.00 Mil725.00 Mil730.00 Mil6.6% RaisedGuidance: 680.00 Mil for 2025
2025 Revenue Growth75.0%76.0%77.0%16.9%11.0%RaisedGuidance: 65.0% for 2025
2025 Clinical therapy selection volume growth21.0%21.5%22.0%7.5%1.5%RaisedGuidance: 20.0% for 2025

Insider Activity

Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Power, Luke ThomasSee RemarksDirectSell1212202526.5862,2501,654,4612,646,367Form
2Denton, John RusselSee RemarksTrustBuy1110202524.094,184100,793221,243Form
3Spetzler, David BaxleyPresidentDirectBuy1107202523.854009,54010,989,531Form
4Denton, John RusselSee RemarksDirectBuy623202521.007,500157,5002,595,411Form
5Brille, Brian JSee RemarksDirectBuy623202521.0030,000630,0003,410,988Form