Bolt Biotherapeutics (BOLT)


Market Price (9/21/2026): $3.56 | Market Cap: $6.0 MilSector: Health Care | Industry: Biotechnology

Bolt Biotherapeutics (BOLT)


Market Price (9/21/2026): $3.56
Market Cap: $6.0 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

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Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.

Weak multi-year price returns
2Y Excs Rtn is -107%, 3Y Excs Rtn is -155%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -28 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -606%

Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 67%

Weak revenue growth
Rev Chg QQuarterly Revenue Change % is -100%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 54%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -669%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -669%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -482%

Key risks
BOLT key risks include [1] a strategic pivot to a high-risk, Show more.

0 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Targeted Therapies, Biopharmaceutical R&D, Show more.
1 Weak multi-year price returns
2Y Excs Rtn is -107%, 3Y Excs Rtn is -155%
2 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -28 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -606%
3 Debt is significant
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is 67%
4 Weak revenue growth
Rev Chg QQuarterly Revenue Change % is -100%
5 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 54%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -669%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -669%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -482%
8 Key risks
BOLT key risks include [1] a strategic pivot to a high-risk, Show more.

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 9/17/2026

Bolt Biotherapeutics (BOLT) stock has lost about 30% since 5/31/2026 because of the following key factors:

1. Bolt Biotherapeutics reported a significantly wider-than-expected net loss for fiscal Q2 2026, ended June 30, 2026. The company's net loss of -$4.57 per share was 32.3% higher than the analyst consensus estimate of -$3.4544, reflecting increased operational expenses or cash burn for a pre-revenue clinical-stage company.

2. The ongoing anticipation and lack of immediate positive clinical data for its lead asset, BDC-4182, likely contributed to investor uncertainty. Throughout the period since May 31, 2026, initial clinical data from the BDC-4182 Phase 1/2 study in gastric and gastroesophageal cancer remained expected for release with Bolt's fiscal Q3 2026 results. This prolonged waiting period for a critical pipeline catalyst, following a previous delay announced in fiscal Q4 2025, may have dampened investor confidence.

Show more
Updated on 9/17/2026

Bolt Biotherapeutics (BOLT) stock has lost about 30% since 5/31/2026 because of the following key factors:

1. Bolt Biotherapeutics reported a significantly wider-than-expected net loss for fiscal Q2 2026, ended June 30, 2026. The company's net loss of -$4.57 per share was 32.3% higher than the analyst consensus estimate of -$3.4544, reflecting increased operational expenses or cash burn for a pre-revenue clinical-stage company.

2. The ongoing anticipation and lack of immediate positive clinical data for its lead asset, BDC-4182, likely contributed to investor uncertainty. Throughout the period since May 31, 2026, initial clinical data from the BDC-4182 Phase 1/2 study in gastric and gastroesophageal cancer remained expected for release with Bolt's fiscal Q3 2026 results. This prolonged waiting period for a critical pipeline catalyst, following a previous delay announced in fiscal Q4 2025, may have dampened investor confidence.

3. The absence of revenue generation continues to highlight Bolt Biotherapeutics' high-risk investment profile. As a clinical-stage entity, the company reported no revenue for fiscal Q2 2026. This, combined with the wider net loss, reinforces the speculative nature of the investment and its susceptibility to volatility in the absence of significant positive clinical or regulatory milestones.

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Stock Movement Drivers

Fundamental Drivers

The -32.2% change in BOLT stock from 5/31/2026 to 9/20/2026 was primarily driven by a -27.7% change in the company's Total Revenues ($ Mil).
(LTM values as of)53120269202026Change
Stock Price ($)5.253.56-32.2%
Change Contribution By: 
Total Revenues ($ Mil)65-27.7%
P/S Multiple1.41.3-5.7%
Shares Outstanding (Mil)22-0.6%
Cumulative Contribution-32.2%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2026 to 9/20/2026
ReturnCorrelation
BOLT-32.2% 
Market (SPY)0.9%6.7%
Sector (XLV)12.7%8.5%

Fundamental Drivers

The -21.2% change in BOLT stock from 2/28/2026 to 9/20/2026 was primarily driven by a -23.3% change in the company's P/S Multiple.
(LTM values as of)22820269202026Change
Stock Price ($)4.523.56-21.2%
Change Contribution By: 
Total Revenues ($ Mil)55-9.5%
P/S Multiple1.71.3-23.3%
Shares Outstanding (Mil)2213.5%
Cumulative Contribution-21.2%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2026 to 9/20/2026
ReturnCorrelation
BOLT-21.2% 
Market (SPY)11.6%6.5%
Sector (XLV)5.5%4.5%

Fundamental Drivers

The -30.6% change in BOLT stock from 8/31/2025 to 9/20/2026 was primarily driven by a -45.8% change in the company's P/S Multiple.
(LTM values as of)83120259202026Change
Stock Price ($)5.133.56-30.6%
Change Contribution By: 
Total Revenues ($ Mil)4512.8%
P/S Multiple2.41.3-45.8%
Shares Outstanding (Mil)2213.4%
Cumulative Contribution-30.6%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 9/20/2026
ReturnCorrelation
BOLT-30.6% 
Market (SPY)19.4%11.2%
Sector (XLV)24.1%6.3%

Fundamental Drivers

The -83.8% change in BOLT stock from 8/31/2023 to 9/20/2026 was primarily driven by a -79.1% change in the company's P/S Multiple.
(LTM values as of)83120239202026Change
Stock Price ($)22.003.56-83.8%
Change Contribution By: 
Total Revenues ($ Mil)75-30.7%
P/S Multiple6.11.3-79.1%
Shares Outstanding (Mil)2211.7%
Cumulative Contribution-83.8%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2023 to 9/20/2026
ReturnCorrelation
BOLT-83.8% 
Market (SPY)75.6%18.4%
Sector (XLV)32.3%15.6%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
BOLT Return-85%-73%-14%-52%-49%-39%-99%
Peers Return-24%-33%7%-16%7%55%-24%
S&P 500 Return27%-19%24%23%16%12%103%

Monthly Win Rates [3]
BOLT Win Rate27%33%50%25%25%44% 
Peers Win Rate40%42%44%58%54%67% 
S&P 500 Win Rate75%42%67%75%67%44% 

Max Drawdowns [4]
BOLT Max Drawdown--74%-56%-67%-63%-55% 
Peers Max Drawdown-47%-64%-43%-54%-50%-33% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: GILD, ZYME, MGNX, STRO.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 9/18/2026 (YTD)

How Low Can It Go

EventBOLTS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-35.9%-9.5%
  % Gain to Breakeven55.9%10.5%
  Time to Breakeven99 days24 days

Compare to GILD, ZYME, MGNX, STRO

In The Past

Bolt Biotherapeutics's stock fell -35.9% during the Summer-Fall 2023 Five Percent Yield Shock. Such a loss loss requires a 55.9% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventBOLTS&P 500
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-35.9%-9.5%
  % Gain to Breakeven55.9%10.5%
  Time to Breakeven99 days24 days

Compare to GILD, ZYME, MGNX, STRO

In The Past

Bolt Biotherapeutics's stock fell -35.9% during the Summer-Fall 2023 Five Percent Yield Shock. Such a loss loss requires a 55.9% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Bolt Biotherapeutics (BOLT)

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Bolt Biotherapeutics is a clinical-stage biotechnology company dedicated to developing innovative immuno-oncology agents. Its core focus is on creating therapies that harness the body's own immune system to identify and destroy cancer cells. The company aims to address significant unmet medical needs by providing novel treatment options for patients facing various solid tumors.

The company's pipeline features several key drug candidates. BDC-1001 is currently in Phase I/II clinical trials, targeting HER2-expressing solid tumors, including HER2-low subtypes. Another program, BDC-2034, is designed to treat cancers such as colorectal, non-small cell lung, pancreatic, and breast cancers by targeting carcinoembryonic antigen. Additionally, Bolt is developing BDC-3042, a Dectin-2 agonist antibody program intended to repolarize critical immune cells like macrophages within the tumor microenvironment to promote anti-tumor activity.

Bolt Biotherapeutics is also advancing a programmed cell death-ligand 1 (PD-L1) program, which seeks to provide therapeutic options for tumors that are unresponsive to conventional immune checkpoint blockade treatments. The primary market for Bolt's investigational therapies encompasses patients with a wide range of solid tumors, particularly those who have limited treatment options or whose cancers are resistant to existing immunotherapies.

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AI Analysis | Feedback

Here are 1-3 brief analogies for Bolt Biotherapeutics:

  • A clinical-stage Genentech focused on activating the immune system to combat cancer.
  • An early-stage Bristol Myers Squibb (BMS) dedicated to discovering novel immuno-oncology treatments.
  • A research-focused Amgen, specializing in developing new immune-based therapies for oncology.

AI Analysis | Feedback

  • BDC-1001: A human epidermal growth factor receptor 2 (HER2) targeting program in clinical trials for HER2-expressing solid tumors.
  • BDC-2034: A carcinoembryonic antigen program targeting colorectal, non-small cell lung, pancreatic, and breast cancers.
  • BDC-3042: A Dectin-2 agonist antibody program designed to repolarize critical cells in the tumor microenvironment.
  • Programmed cell death-ligand 1 program: A program aimed at treating tumors that are nonresponsive to immune checkpoint blockade.

AI Analysis | Feedback

Bolt Biotherapeutics (BOLT) is a clinical-stage biotechnology company primarily engaged in the research and development of immuno-oncology agents. As described, the company's drug candidates, including BDC-1001, BDC-2034, and BDC-3042, are currently in various phases of clinical trials (e.g., Phase I/II) or earlier stages of development.

At its current stage, Bolt Biotherapeutics does not have commercialized products available for sale on the market, nor does it generate revenue from product sales to major customers. Therefore, the company does not have identifiable major customer companies or categories of individual customers in the traditional sense of product purchasers.

AI Analysis | Feedback

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AI Analysis | Feedback

Willie Quinn, Chief Executive Officer

Willie Quinn was appointed Chief Executive Officer of Bolt Biotherapeutics in May 2024. He joined Bolt in 2020, bringing extensive experience in finance, operations, and business development in the biopharma industry. Prior to becoming CEO, he served as the company's Chief Financial Officer. Mr. Quinn previously served as the chief financial officer and senior vice president of corporate development at Sunesis Pharmaceuticals (acquired by Viracta Therapeutics), where he led multiple public financings and corporate collaborations. He also co-founded Bullet Biotechnology, serving as its chief executive officer, focused on developing cancer immunotherapies. Additionally, Mr. Quinn was an early employee at Jazz Pharmaceuticals, working there for over eight years, and was the chief financial officer and chief operating officer of Novation Biosciences, which was acquired by Agilent Technologies.

Sarah Nemec, SVP, Finance and Principal Accounting Officer

Sarah Nemec was appointed Senior Vice President, Finance and Principal Accounting Officer at Bolt Biotherapeutics in May 2024. She joined the company in 2020 and has over 20 years of experience as a senior finance leader in the life science industry.

Grant Yonehiro, Chief Operating Officer

Grant Yonehiro was promoted to Chief Operating Officer of Bolt Biotherapeutics in May 2024, having joined the company in 2016.

Michael N. Alonso, Ph.D., SVP, Research

Michael N. Alonso, Ph.D., is a scientific co-founder of Bolt Biotherapeutics and a co-inventor of its proprietary ISAC platform. He was promoted to Senior Vice President, Research, in May 2024.

Dawn Colburn, Pharm.D., Senior Vice President, Clinical Development

Dawn Colburn, Pharm.D., was promoted to Senior Vice President, Clinical Development, at Bolt Biotherapeutics in May 2024, overseeing all clinical activities.

AI Analysis | Feedback

Here are the key risks to Bolt Biotherapeutics:

1. Clinical Trial Failure and Regulatory Approval Risks

Bolt Biotherapeutics, as a clinical-stage biotechnology company, faces significant inherent uncertainties in the outcomes of its clinical trials and the subsequent ability to secure regulatory approvals. The company recently discontinued the development of its lead antibody-drug conjugate candidate, BDC-1001, after determining it did not meet its "high bar for advancement". This highlights the substantial risk that potential product candidates may not progress successfully through clinical development or receive necessary regulatory approvals within anticipated timelines, or at all. Clinical trials may also fail to confirm the safety, potency, or other desired characteristics of their products.

2. Financial Health and Going Concern Risks

The company is currently categorized as a "Distressed" stock, with a GF Score of 58, indicating potential value traps. Bolt Biotherapeutics faces considerable challenges with profitability, evidenced by negative operating and net margins of -860.39% and -821.58%, respectively. Furthermore, an Altman Z-Score of -11.24 places the company in a distress zone, suggesting a potential risk of bankruptcy within the next two years, and its Piotroski F-Score of 1 indicates poor business operations. The company is rapidly depleting its resources, with a negative free cash flow exceeding $51 million in the last twelve months. To conserve capital and extend its cash runway into 2027, Bolt Biotherapeutics implemented a workforce reduction of approximately 50%.

3. Dependence on Collaborations

The company's ability to maintain its existing collaborations and establish new ones is a key risk. For instance, forming a partnership for BDC-3042, a Dectin-2 agonist monoclonal antibody, has been identified as a crucial near-term catalyst for the company. A significant portion of Bolt's ISAC research is supported by collaborations with partners like Genmab and Toray. Should these collaborations not be maintained or if the company is unable to secure new strategic partnerships, its ability to fund and advance its pipeline candidates could be significantly impacted.

AI Analysis | Feedback

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AI Analysis | Feedback

The addressable markets for Bolt Biotherapeutics' main products are as follows:

  • BDC-1001 (HER2-expressing solid tumors, including HER2-low tumors): The global HER2-targeted therapy market is estimated at approximately $20 billion in 2025 and is projected to reach about $35 billion by 2033, growing at a compound annual growth rate (CAGR) of 8%. Specifically for HER2-low cancers, the market in the 7 major markets (7MM: United States, EU4 (Germany, France, Italy, and Spain), United Kingdom, and Japan) is valued at approximately USD 3.53 billion in 2025 and is projected to reach USD 8.997 billion by 2034, with a CAGR of 11%.
  • BDC-2034 (carcinoembryonic antigen program for colorectal, non-small cell lung, pancreatic, and breast cancers):
    • For colorectal cancer, the global therapeutics market is projected to grow from USD 13.37 billion in 2025 to USD 19.95 billion by 2034, at a CAGR of 4.55%.
    • For non-small cell lung cancer (NSCLC), the global market is estimated to be valued at USD 28.61 billion in 2025 and is expected to reach USD 54.38 billion by 2032, exhibiting a CAGR of 9.6%.
    • For pancreatic cancer, the global market is estimated at USD 3.25 billion in 2025 and is projected to surpass USD 10.25 billion by 2034, growing at a CAGR of 13.62%.
    • For breast cancer, the global drugs market was estimated at USD 36.62 billion in 2024 and is projected to reach USD 69.72 billion by 2033, growing at a CAGR of 7.09%.
    • The global carcinoembryonic antigen (CEA) market, which indicates the diagnostic and monitoring relevance of CEA, is projected to be between $3.10 billion and $4.62 billion from 2024 to 2030. North America held a significant share of approximately $725.89 million in 2025.
  • BDC-3042 (Dectin-2 agonist antibody program developed to repolarize critical cells in the tumor microenvironment by targeting cell-surface receptors on macrophages): The global tumor microenvironment targeted oncology therapies market reached US$1.92 billion in 2025 and is expected to reach US$5.11 billion by 2033, growing at a CAGR of 13% from 2026 to 2033. North America dominated this market with a 42.7% revenue share in 2025.
  • Programmed cell death-ligand 1 (PD-L1) program for tumors that are nonresponsive to immune checkpoint blockade: The broader global immune checkpoint inhibitors market is expected to grow from USD 50.29 billion in 2025 to USD 123.57 billion by 2031, at a CAGR of 16.18%. This market includes PD-L1 inhibitors and addresses the need for therapies in tumors with adaptive resistance or "cold" tumors, a segment that Bolt Biotherapeutics' program aims to target.

AI Analysis | Feedback

Bolt Biotherapeutics (NASDAQ: BOLT), a clinical-stage biotechnology company, anticipates its future revenue growth over the next 2-3 years will be primarily driven by the advancement of its pipeline candidates and strategic collaborations.

  1. Advancement of BDC-4182 through Clinical Trials: The company's next-generation Boltbody™ Immune-Stimulating Antibody Conjugate (ISAC), BDC-4182, targeting claudin 18.2, is currently in a Phase 1 dose-escalation study for gastric and gastroesophageal cancer. Initial clinical data from this study is expected in the third quarter of 2026. Positive clinical data and progression through further trial phases could attract additional investment, trigger milestone payments from potential partners, and move the candidate closer to eventual commercialization.
  2. Successful Partnering of BDC-3042: Bolt Biotherapeutics is actively seeking a partner to advance the development of BDC-3042, a Dectin-2 agonist antibody program. BDC-3042 has completed a Phase 1 dose-escalation trial, demonstrating a favorable safety profile, dose-dependent biological activity, and signs of monotherapy anti-tumor activity. Securing a partnership would likely generate upfront payments and potential milestone payments as the program progresses, contributing to future revenue.
  3. Expansion and Progress of Strategic Collaborations: Bolt Biotherapeutics has ongoing strategic collaborations with companies such as Genmab and Toray, which are built around its proprietary Boltbody™ ISAC platform technology. Continued progress in these existing collaborations, as well as the potential for forming new strategic partnerships for other ISAC programs, is expected to generate collaboration revenue.

AI Analysis | Feedback

Share Repurchases

No information regarding share repurchase programs or activities by Bolt Biotherapeutics was identified in the provided context for the last 3-5 years.

Share Issuance

  • Bolt Biotherapeutics had its Initial Public Offering (IPO) in 2021.
  • A one-for-twenty reverse stock split was implemented, which adjusted the number of outstanding shares.

Inbound Investments

  • For the full year ended December 31, 2025, Bolt Biotherapeutics reported collaboration revenue of $7.7 million from arrangements with strategic partners like Toray, Genmab, and Innovent, which support its research and development activities.
  • Tang Capital affiliates and Kevin Tang collectively reported beneficial ownership of 166,879 shares of common stock, representing 8.7% of the class on a post-reverse-split basis.

Outbound Investments

No information regarding strategic investments made by Bolt Biotherapeutics in other companies was identified in the provided context for the last 3-5 years.

Capital Expenditures

  • In the last 12 months prior to March 2026, capital expenditures were -$72,000.
  • Capital expenditures consumed $41,000 for the year ended December 31, 2025.

Better Bets vs. Bolt Biotherapeutics (BOLT)

Peer Outperformance in Biotechnology

BOLT has trailed 85% of its 363 Biotechnology peers over 5Y. Biotechnology ranks 10th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that BOLT has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
35%
of 455 industry peers · -31.9% return
3Y
23%
of 402 industry peers · -83.7% return
5Y
15%
of 363 industry peers · -98.8% return
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Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is BOLT's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 6 16.2%43.2%90.1% CAH 392% · MCK 346% · COR 168%
Managed Health Care 8 40.4%-5.3%2.3% OSCR 84% · HQY 56% · ELV 17%
Health Care Services 20 21.1%37.6%-0.3% HIMS 239% · RDNT 173% · DGX 76%
Health Care Facilities 24 6.0%6.5%-4.5% NHC 271% · THC 261% · ENSG 129%
Health Care Equipment 50 -2.7%-0.2%-21.1% POCI 11050% · UFPT 341% · GKOS 222%
Pharmaceuticals 62 -10.5%14.8%-38.6% LQDA 2472% · INDV 1099% · ETON 1051%
Health Care Supplies 12 14.1%-8.9%-39.7% LNTH 287% · HAE 54% · MMSI 20%
Life Sciences Tools & Services 109 4.3%-11.3%-68.4% SNWV 1757% · MEDP 231% · NTRA 199%
Health Care Technology 21 -25.8%-52.6%-79.2% SPOK 68% · HSTM 3% · VEEV -13%
Biotechnology ← 364 0.6%-21.7%-79.4% CELZ 1280% · DNTH 1221% · ELVN 1069%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Latest Trefis Analyses

Title
0ARTICLES

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

BOLTGILDZYMEMGNXSTROMedian
NameBolt Bio.Gilead S.ZymeworksMacrogen.Sutro Bi. 
Mkt Price3.56150.1126.574.1415.3415.34
Mkt Cap0.0186.61.90.30.30.3
Rev LTM530,456371684646
Op Inc LTM-2811,716-155-41-132-41
FCF LTM-3112,943-121-66-146-66
FCF 3Y Avg-499,736-86-99-158-86
CFO LTM-3113,552-119-64-145-64
CFO 3Y Avg-4910,296-83-96-156-83

Growth & Margins

BOLTGILDZYMEMGNXSTROMedian
NameBolt Bio.Gilead S.ZymeworksMacrogen.Sutro Bi. 
Rev Chg LTM12.8%5.5%-69.8%11.7%-56.3%5.5%
Rev Chg 3Y Avg4.9%3.6%-19.9%68.3%34.4%4.9%
Rev Chg Q-99.7%10.2%-90.6%378.0%-84.6%-84.6%
QoQ Delta Rev Chg LTM-27.7%2.4%-54.3%18.3%-54.1%-27.7%
Op Inc Chg LTM46.7%7.6%-87.9%51.8%20.4%20.4%
Op Inc Chg 3Y Avg27.9%-0.8%-73.6%1.5%-0.8%-0.8%
Op Mgn LTM-605.9%38.5%-418.8%-24.3%-288.5%-288.5%
Op Mgn 3Y Avg-850.5%37.0%-225.9%-186.8%-169.9%-186.8%
QoQ Delta Op Mgn LTM-142.4%-1.6%-278.5%25.2%-201.1%-142.4%
CFO/Rev LTM-669.2%44.5%-321.4%-38.0%-317.7%-317.7%
CFO/Rev 3Y Avg-824.7%35.2%-166.2%-153.4%-200.0%-166.2%
FCF/Rev LTM-669.2%42.5%-325.1%-39.1%-318.6%-318.6%
FCF/Rev 3Y Avg-825.2%33.3%-170.6%-157.2%-201.9%-170.6%

Valuation

BOLTGILDZYMEMGNXSTROMedian
NameBolt Bio.Gilead S.ZymeworksMacrogen.Sutro Bi. 
Mkt Cap0.0186.61.90.30.30.3
P/S1.36.152.21.65.65.6
P/Op Inc-0.215.9-12.5-6.5-1.9-1.9
P/EBIT-0.2-195.0-13.0-3.0-1.8-3.0
P/E-0.2-57.6-12.9-18.0-1.4-12.9
P/CFO-0.213.8-16.3-4.1-1.8-1.8
Total Yield-477.5%0.4%-7.7%-5.5%-71.1%-7.7%
Dividend Yield0.0%2.2%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-390.5%7.7%-8.5%-59.6%-157.9%-59.6%
D/E3.60.10.00.10.00.1
Net D/E0.70.1-0.1-0.5-0.6-0.1

Returns

BOLTGILDZYMEMGNXSTROMedian
NameBolt Bio.Gilead S.ZymeworksMacrogen.Sutro Bi. 
1M Rtn-2.9%3.3%-7.3%1.0%-27.1%-2.9%
3M Rtn-10.8%22.0%14.8%0.2%-48.2%0.2%
6M Rtn-25.2%10.7%13.9%44.8%-25.8%10.7%
12M Rtn-31.9%34.8%63.5%155.6%73.0%63.5%
3Y Rtn-83.7%119.2%311.3%-11.5%-54.6%-11.5%
1M Excs Rtn9.9%3.0%-1.6%0.0%-29.2%0.0%
3M Excs Rtn-12.8%20.0%12.8%-1.8%-50.2%-1.8%
6M Excs Rtn-37.4%-8.1%-4.6%27.0%-43.2%-8.1%
12M Excs Rtn-49.6%21.1%51.5%154.7%64.0%51.5%
3Y Excs Rtn-155.1%44.3%216.6%-85.9%-138.2%-85.9%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Single Segment88861
Total88861


Assets by Segment
$ Mil2018
Single Segment16
Total16


Price Behavior

Price Behavior
Market Price$3.56 
Market Cap ($ Bil)0.0 
First Trading Date02/05/2021 
Distance from 52W High-49.8% 
   50 Days200 Days
DMA Price$3.83$4.71
DMA Trenddowndown
Distance from DMA-7.0%-24.4%
 3M1YR
Volatility74.3%76.7%
Downside Capture-0.90117.81
Upside Capture-60.9752.40
Correlation (SPY)-11.3%11.8%
BOLT Betas & Captures as of 8/31/2026

 1M2M3M6M1Y3Y
Beta0.510.410.510.420.720.83
Up Beta-1.03-1.76-1.07-1.33-0.060.62
Down Beta2.302.821.731.041.101.30
Up Capture76%47%-13%56%48%8%
Bmk +ve Days10213268138427
Stock +ve Days9213058117336
Down Capture137%66%122%113%108%103%
Bmk -ve Days11213259113324
Stock -ve Days11193264128387

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BOLT
BOLT-33.8%76.3%-0.22-
Sector ETF (XLV)24.4%16.1%1.166.6%
Equity (SPY)16.9%12.9%0.9411.6%
Gold (GLD)19.1%29.3%0.6013.1%
Commodities (DBC)46.3%20.6%1.730.9%
Real Estate (VNQ)4.9%13.6%0.10-1.6%
Bitcoin (BTCUSD)-30.6%44.3%-0.7027.9%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BOLT
BOLT-59.6%74.4%-0.87-
Sector ETF (XLV)6.4%15.2%0.2416.0%
Equity (SPY)12.9%17.2%0.5719.6%
Gold (GLD)19.1%18.8%0.833.1%
Commodities (DBC)11.2%19.5%0.45-0.4%
Real Estate (VNQ)1.1%18.8%-0.0513.1%
Bitcoin (BTCUSD)12.5%52.5%0.4214.7%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with BOLT
BOLT-40.5%75.3%-0.87-
Sector ETF (XLV)10.6%16.7%0.5115.3%
Equity (SPY)15.1%18.0%0.7219.0%
Gold (GLD)12.1%16.4%0.614.5%
Commodities (DBC)8.3%18.1%0.370.7%
Real Estate (VNQ)4.4%20.7%0.1812.2%
Bitcoin (BTCUSD)62.6%66.2%1.0213.8%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date8312026
Short Interest: Shares Quantity0.0 Mil
Short Interest: % Change Since 81520261923.2%
Average Daily Volume0.0 Mil
Days-to-Cover Short Interest1
Basic Shares Quantity1.7 Mil
Short % of Basic Shares0.9%

Earnings Returns History

Updated 9/14/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/11/2026-13.3%-20.2%-6.3%
5/12/20261.0%-1.3%-0.2%
3/12/2026-3.5%12.1%15.1%
11/12/20250.2%-0.2%14.9%
8/14/2025-5.3%-10.1%-2.2%
5/12/2025-6.7%-11.4%-11.8%
3/24/2025-4.0%-8.6%-15.0%
11/12/2024-3.9%-12.6%-17.6%
...
SUMMARY STATS   
# Positive876
# Negative111213
Median Positive2.8%6.4%15.0%
Median Negative-4.0%-9.4%-11.7%
Max Positive12.5%20.7%32.0%
Max Negative-13.3%-20.2%-60.2%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/11/2026-13.3%-20.2%-6.3%
5/12/20261.0%-1.3%-0.2%
3/12/2026-3.5%12.1%15.1%
11/12/20250.2%-0.2%14.9%
8/14/2025-5.3%-10.1%-2.2%
5/12/2025-6.7%-11.4%-11.8%
3/24/2025-4.0%-8.6%-15.0%
11/12/2024-3.9%-12.6%-17.6%
8/13/2024-1.4%-1.5%-11.7%
3/21/20243.4%20.7%-4.3%
11/9/2023-1.0%-3.1%-7.1%
8/7/20230.8%-3.9%-14.2%
5/11/202312.5%18.8%1.9%
11/10/20223.1%0.0%1.6%
8/10/2022-6.3%-19.4%-29.8%
5/12/2022-2.6%6.4%25.6%
11/9/2021-4.8%-11.0%-60.2%
8/12/20214.7%4.0%32.0%
5/13/20212.5%2.3%-11.0%
SUMMARY STATS   
# Positive876
# Negative111213
Median Positive2.8%6.4%15.0%
Median Negative-4.0%-9.4%-11.7%
Max Positive12.5%20.7%32.0%
Max Negative-13.3%-20.2%-60.2%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/11/202610-Q
03/31/202605/12/202610-Q
12/31/202503/12/202610-K
09/30/202511/12/202510-Q
06/30/202508/14/202510-Q
03/31/202505/12/202510-Q
12/31/202403/24/202510-K
09/30/202411/12/202410-Q
06/30/202408/13/202410-Q
03/31/202405/14/202410-Q
12/31/202303/21/202410-K
09/30/202311/09/202310-Q
06/30/202308/07/202310-Q
03/31/202305/11/202310-Q
12/31/202203/29/202310-K
09/30/202211/10/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/11/202610-Q
03/31/202605/12/202610-Q
12/31/202503/12/202610-K
09/30/202511/12/202510-Q
06/30/202508/14/202510-Q
03/31/202505/12/202510-Q
12/31/202403/24/202510-K
09/30/202411/12/202410-Q
06/30/202408/13/202410-Q
03/31/202405/14/202410-Q
12/31/202303/21/202410-K
09/30/202311/09/202310-Q
06/30/202308/07/202310-Q
03/31/202305/11/202310-Q
12/31/202203/29/202310-K
09/30/202211/10/202210-Q
06/30/202208/10/202210-Q
03/31/202205/12/202210-Q
12/31/202103/30/202210-K
09/30/202111/09/202110-Q
06/30/202108/12/202110-Q
03/31/202105/13/202110-Q
12/31/202003/31/202110-K
09/30/202002/05/2021424B4

Recent Forward Guidance

Updated 8/12/2026

Latest: Q2 2026 Earnings Reported 8/11/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported     AffirmedGuidance: 2,027 for 2027


Prior: Q1 2026 Earnings Reported 5/12/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported 2,027    

Q4 2025 Earnings Reported 3/12/2026

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported      

Q3 2025 Earnings Reported 11/12/2025

Forward GuidanceGuidance Change
MetricSourceLowMidHigh% Chg% DeltaChangePrior
2027 Cash RunwayReported      

Insider Activity

Updated 6/11/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Quinn, William PPresident, CEO and CFODirectBuy20420264.6112557610,656Form
2Nemec, SarahSenior VP, Finance and PAODirectBuy20420264.611255766,519Form
3Nemec, SarahSenior VP, Finance and PAODirectBuy102420255.491256865,179Form
4Quinn, William PPresident, CEO and CFODirectBuy102420255.4912568612,016Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Quinn, William PPresident, CEO and CFODirectBuy20420264.6112557610,656Form
2Nemec, SarahSenior VP, Finance and PAODirectBuy20420264.611255766,519Form
3Nemec, SarahSenior VP, Finance and PAODirectBuy102420255.491256865,179Form
4Quinn, William PPresident, CEO and CFODirectBuy102420255.4912568612,016Form
Core Cache Last Updated: 9/20/2026