Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -35%

Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.

Weak multi-year price returns
2Y Excs Rtn is -53%, 3Y Excs Rtn is -65%

Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.6

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -0.4 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -0.7%

Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -15%, Rev Chg QQuarterly Revenue Change % is -6.5%

Not cash flow generative
FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -5.9%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -99%

High stock price volatility
Vol 12M is 114%

Key risks
AYTU key risks include [1] significant financial distress and bankruptcy risk due to ongoing losses and high debt, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -35%
1 Megatrend and thematic drivers
Megatrends include Precision Medicine, and Aging Population & Chronic Disease. Themes include Biopharmaceutical R&D, Targeted Therapies, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -53%, 3Y Excs Rtn is -65%
3 Meaningful short interest
Short Interest Days-to-CoverDTC = (Short Interest Share Quantity) / (Average Daily Trading Volume). Reflects how many days it would take to cover (close out) the short interest based on average volumes. High DTC can signify an increased risk of a short squeeze. is 13.6
4 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -0.4 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -0.7%
5 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -15%, Rev Chg QQuarterly Revenue Change % is -6.5%
6 Not cash flow generative
FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -5.9%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -99%
8 High stock price volatility
Vol 12M is 114%
9 Key risks
AYTU key risks include [1] significant financial distress and bankruptcy risk due to ongoing losses and high debt, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Aytu BioPharma (AYTU) stock has remained largely at the same level since 1/31/2026 because of the following key factors:

1. Mixed Fiscal Q2 2026 Financial Performance and Launch Investments for EXXUA. Aytu BioPharma reported a net loss of $10.6 million ($1.05 per share) for the fiscal second quarter ended December 31, 2025, a significant decline from a net income of $0.8 million ($0.13 per share) in the prior-year period. This loss was primarily driven by an $8.2 million derivative warrant liability loss. Net revenue also decreased to $15.2 million from $16.2 million year-over-year. While the company commercially launched its new major depressive disorder drug, EXXUA, in December 2025, generating initial revenue of $0.2 million, the increased operating expenses associated with this launch led to a negative Adjusted EBITDA of $0.8 million. This financial performance likely balanced out investor sentiment, keeping the stock largely stable.

2. Share Dilution and Financial Health Concerns. Shareholders experienced substantial dilution, with total shares outstanding growing by 74% in the past year, reaching 19.5 million shares outstanding as of February 3, 2026 (including common shares and prefunded warrants). Furthermore, the company's Altman Z-Score of -3.23 suggests an increased risk of bankruptcy, a factor that can deter significant upward stock movement. These concerns about dilution and financial stability likely weighed on the stock, counteracting any positive news.

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Stock Movement Drivers

Fundamental Drivers

The -1.2% change in AYTU stock from 1/31/2026 to 5/5/2026 was primarily driven by a -5.9% change in the company's Shares Outstanding (Mil).
(LTM values as of)13120265052026Change
Stock Price ($)2.602.57-1.2%
Change Contribution By: 
Total Revenues ($ Mil)6463-1.7%
P/S Multiple0.40.46.9%
Shares Outstanding (Mil)910-5.9%
Cumulative Contribution-1.2%

LTM = Last Twelve Months as of date shown

Market Drivers

1/31/2026 to 5/5/2026
ReturnCorrelation
AYTU-1.2% 
Market (SPY)3.6%37.1%
Sector (XLV)-5.7%23.5%

Fundamental Drivers

The 13.2% change in AYTU stock from 10/31/2025 to 5/5/2026 was primarily driven by a 77.5% change in the company's P/S Multiple.
(LTM values as of)103120255052026Change
Stock Price ($)2.272.5713.2%
Change Contribution By: 
Total Revenues ($ Mil)6663-5.6%
P/S Multiple0.20.477.5%
Shares Outstanding (Mil)710-32.4%
Cumulative Contribution13.2%

LTM = Last Twelve Months as of date shown

Market Drivers

10/31/2025 to 5/5/2026
ReturnCorrelation
AYTU13.2% 
Market (SPY)5.5%25.0%
Sector (XLV)1.6%20.7%

Fundamental Drivers

The 90.4% change in AYTU stock from 4/30/2025 to 5/5/2026 was primarily driven by a 205.5% change in the company's P/S Multiple.
(LTM values as of)43020255052026Change
Stock Price ($)1.352.5790.4%
Change Contribution By: 
Total Revenues ($ Mil)61632.0%
P/S Multiple0.10.4205.5%
Shares Outstanding (Mil)610-38.9%
Cumulative Contribution90.4%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2025 to 5/5/2026
ReturnCorrelation
AYTU90.4% 
Market (SPY)30.4%13.6%
Sector (XLV)5.3%13.8%

Fundamental Drivers

The 9.4% change in AYTU stock from 4/30/2023 to 5/5/2026 was primarily driven by a 494.8% change in the company's P/S Multiple.
(LTM values as of)43020235052026Change
Stock Price ($)2.352.579.4%
Change Contribution By: 
Total Revenues ($ Mil)10663-40.7%
P/S Multiple0.10.4494.8%
Shares Outstanding (Mil)310-69.0%
Cumulative Contribution9.4%

LTM = Last Twelve Months as of date shown

Market Drivers

4/30/2023 to 5/5/2026
ReturnCorrelation
AYTU9.4% 
Market (SPY)78.7%14.1%
Sector (XLV)14.4%12.7%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
AYTU Return-77%-86%-25%-40%53%-2%-98%
Peers Return29%35%-23%14%34%32%174%
S&P 500 Return27%-19%24%23%16%5%92%

Monthly Win Rates [3]
AYTU Win Rate17%17%42%33%50%20% 
Peers Win Rate53%58%48%50%47%56% 
S&P 500 Win Rate75%42%67%75%67%40% 

Max Drawdowns [4]
AYTU Max Drawdown-77%-89%-61%-53%-41%-18% 
Peers Max Drawdown-29%-30%-37%-21%-21%-13% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-7% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: AXSM, SUPN, ASRT, CPIX, PBH.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 5/5/2026 (YTD)

How Low Can It Go

EventAYTUS&P 500
2025 US Tariff Shock
  % Loss-27.5%-18.8%
  % Gain to Breakeven38.0%23.1%
  Time to Breakeven38 days79 days
2024 Yen Carry Trade Unwind
  % Loss-16.3%-7.8%
  % Gain to Breakeven19.4%8.5%
  Time to Breakeven45 days18 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-12.1%-9.5%
  % Gain to Breakeven13.7%10.5%
  Time to Breakeven13 days24 days
2023 SVB Regional Banking Crisis
  % Loss-52.8%-6.7%
  % Gain to Breakeven112.1%7.1%
  Time to Breakeven112 days31 days
2020 COVID-19 Crash
  % Loss-52.0%-33.7%
  % Gain to Breakeven108.3%50.9%
  Time to Breakeven1 days140 days

Compare to AXSM, SUPN, ASRT, CPIX, PBH

In The Past

Aytu BioPharma's stock fell -27.5% during the 2025 US Tariff Shock. Such a loss loss requires a 38.0% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventAYTUS&P 500
2025 US Tariff Shock
  % Loss-27.5%-18.8%
  % Gain to Breakeven38.0%23.1%
  Time to Breakeven38 days79 days
2023 SVB Regional Banking Crisis
  % Loss-52.8%-6.7%
  % Gain to Breakeven112.1%7.1%
  Time to Breakeven112 days31 days
2020 COVID-19 Crash
  % Loss-52.0%-33.7%
  % Gain to Breakeven108.3%50.9%
  Time to Breakeven1 days140 days

Compare to AXSM, SUPN, ASRT, CPIX, PBH

In The Past

Aytu BioPharma's stock fell -27.5% during the 2025 US Tariff Shock. Such a loss loss requires a 38.0% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Aytu BioPharma (AYTU)

Aytu Biopharma, Inc., a specialty pharmaceutical company, focuses on developing and commercializing novel therapeutics and consumer healthcare products the United States and internationally. The company offers Adzenys XR-ODT for the treatment of attention deficit hyperactivity disorder (ADHD) in patients from 6 years and older; Cotempla XR-ODT for the treatment of ADHD in patients from 6 to 17 years old; and Adzenys ER, an oral suspension for the treatment of ADHD in patients from 6 years and older. It also provides Karbinal ER, a carbinoxamine oral suspension for the treatment of seasonal and perennial allergies; Poly-Vi-Flor and Tri-Vi-Flor prescription supplements for infants and children for the treatment of fluoride deficiency; Tuzistra XR, a prescription antitussive consisting of codeine polistirex and chlorpheniramine polistirex in an oral suspension; and ZolpiMist, an oral spray for the treatment of insomnia. The company was formerly known as Aytu BioScience, Inc. and changed its name to Aytu Biopharma, Inc. in March 2021. Aytu Biopharma, Inc. was incorporated in 2015 and is headquartered in Englewood, Colorado.

AI Analysis | Feedback

Here are 1-3 brief analogies for Aytu BioPharma (AYTU):

  • Aytu BioPharma is like a mini-Bausch Health, specializing in commercializing a diverse portfolio of unique-formulation prescription drugs for common conditions.
  • Aytu BioPharma is like a smaller, specialized Johnson & Johnson for prescription medications, focusing on unique formulations for common conditions like ADHD, allergies, and insomnia.

AI Analysis | Feedback

  • Adzenys XR-ODT: An extended-release orally disintegrating tablet for treating ADHD in patients aged 6 and older.
  • Cotempla XR-ODT: An extended-release orally disintegrating tablet for treating ADHD in patients aged 6 to 17.
  • Adzenys ER: An extended-release oral suspension for treating ADHD in patients aged 6 and older.
  • Karbinal ER: A carbinoxamine oral suspension used for the treatment of seasonal and perennial allergies.
  • Poly-Vi-Flor and Tri-Vi-Flor: Prescription supplements for infants and children to treat fluoride deficiency.
  • Tuzistra XR: A prescription antitussive oral suspension containing codeine polistirex and chlorpheniramine polistirex.
  • ZolpiMist: An oral spray for the treatment of insomnia.

AI Analysis | Feedback

Aytu BioPharma (AYTU), as a specialty pharmaceutical company focused on prescription therapeutics, primarily sells its products to other companies within the healthcare supply chain rather than directly to individual consumers. Its major customers are typically pharmaceutical wholesale distributors and large retail pharmacy chains.

The major customer companies for Aytu BioPharma include:

  • McKesson Corporation (MCK)
  • AmerisourceBergen Corporation (ABC)
  • Cardinal Health, Inc. (CAH)

These companies are the primary pharmaceutical wholesalers in the United States, responsible for distributing prescription medications from manufacturers to retail pharmacies, hospitals, and other healthcare providers.

AI Analysis | Feedback

  • Catalent Pharma Solutions (CTLT)
  • KVK-Tech, Inc.
  • DPT Laboratories, Ltd.
  • Thermo Fisher Scientific (TMO)
  • Cardinal Health (CAH)

AI Analysis | Feedback

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Josh Disbrow

Chief Executive Officer and Board Director

Mr. Disbrow co-founded Aytu BioPharma in 2015 and led the company's NASDAQ listing in 2017. He previously co-founded Arbor Pharmaceuticals with his twin brother Jarrett Disbrow, serving as Vice President of Commercial Operations. Under his commercial leadership, Arbor Pharmaceuticals grew to over $250 million in annual revenue before its acquisition in 2010. He also served as Chief Operating Officer of Ampio Pharmaceuticals and Chief Executive Officer of its subsidiary Luoxis Diagnostics, Inc. Prior to that, he held commercial roles at LipoScience (which was later acquired by LabCorp), Cyberonics, and Glaxo Wellcome. He has overseen four strategic company acquisitions for Aytu BioPharma.

Ryan Selhorn

Chief Financial Officer, Corporate Secretary and Treasurer

Mr. Selhorn was appointed Chief Financial Officer in November 2024. He previously served as Aytu's Executive Vice President, Finance and Business Optimization since November 2022, and as Senior Vice President, Finance and Operations, Consumer Healthcare Division from February 2022 to November 2022. Before joining Aytu, he held the position of Vice President and Chief Financial Officer at Innovus Pharmaceuticals, Inc., a publicly held consumer healthcare company, until its acquisition by Aytu in February 2020. Mr. Selhorn also served as Chief Financial Officer and Chief Accounting Officer of Signature Analytics, a privately held fractional CFO and accounting firm, where he additionally acted as Chief Financial Officer of Medicinova, Inc., a publicly held biotechnology company. He began his career at Grant Thornton LLP, working in Transaction Advisory Services.

Jarrett Disbrow

Chief Business Officer

Mr. Disbrow co-founded Aytu BioPharma in April 2015 with his brother Josh Disbrow. He has held several senior leadership roles at Aytu, including President, Consumer Health (until July 2024), Executive Vice President of Corporate Operations, Corporate Development, Marketing & Market Access, and Chief Operating Officer/Head of Commercial. Prior to Aytu, he was President & CEO of Vyrix Pharmaceuticals, a specialty pharmaceutical company focused on male sexual dysfunction. He also co-founded Arbor Pharmaceuticals, initially focused on pediatrics, and was responsible for its vision, fundraising, strategy, and growth until its acquisition in 2010. His earlier experience includes commercial leadership roles at Accentia Biopharmaceuticals and GlaxoWellcome.

Greg Pyszczymuka

Chief Commercial Officer

Mr. Pyszczymuka has served as Aytu BioPharma's Chief Commercial Officer since January 2022. Before the company's merger with Neos Therapeutics in March 2021, he was the Vice President, Commercial at Neos Therapeutics since June 2020. His roles at Neos Therapeutics also included Vice President, Commercial Strategy & Market Access, and Executive Director of Channel Strategy & Access Programs.

Margaret Cabano

Vice President of Operations

Ms. Cabano has served as Vice President of Operations for Aytu BioPharma since the merger of Aytu BioPharma and Neos Therapeutics in 2021. She previously held the same role for Neos Therapeutics starting in 2005. With 21 years of industry experience, Ms. Cabano oversees all aspects of manufacturing operations, including supply chain, engineering, and technical services. Before her time at Neos, she worked in operations and supply chain management for Adams Respiratory Therapeutics and Cardinal Health.

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AI Analysis | Feedback

The key risks to Aytu BioPharma's business are:

Generic Competition for Core ADHD Products

The most significant risk to Aytu BioPharma is the impending generic competition for its primary revenue-generating ADHD medications, Adzenys XR-ODT and Cotempla XR-ODT. Teva Pharmaceutical is set to launch generic versions of Adzenys XR-ODT in September 2025 and Cotempla XR-ODT in July 2026, without paying royalties to Aytu. This is a critical threat as the ADHD portfolio accounted for 83% of Aytu's revenue in Q3 fiscal 2025. The patents for Adzenys XR-ODT were scheduled to expire in 2026 and 2032, but an earlier settlement agreement allows for generic entry. This loss of exclusivity is expected to substantially impact the company's revenue and profitability.

Financial Performance and Sustained Profitability Challenges

Aytu BioPharma faces ongoing challenges in achieving and sustaining profitability. Recent financial reports show a decline in net revenue and a net loss in Q2 2026, which led to a drop in the stock price. While the company is working towards achieving cash breakeven and positive adjusted EBITDA, consistent profitability remains a concern, particularly with the looming generic competition for its main products. The company's stock is also considered "high risk" due to significant daily price movements and periodic low trading volume.

Regulatory Scrutiny and Past Legal Issues

Aytu BioPharma has faced regulatory challenges and legal scrutiny. In September 2025, the U.S. Food and Drug Administration (FDA) issued warning letters to Aytu BioPharma regarding misleading promotional communications for Adzenys XR-ODT and Cotempla XR-ODT. The FDA cited the omission of important risk information and failure to prominently display the established drug names, raising concerns about regulatory compliance. Additionally, a shareholder derivative lawsuit alleging fiduciary breaches and unjust enrichment by company directors was settled in January 2025. Although the lawsuit is resolved, these instances highlight potential risks associated with regulatory adherence and corporate governance.

AI Analysis | Feedback

The increasing regulatory scrutiny and public health concerns surrounding opioid-containing medications, particularly for cough and cold treatments, pose an emerging threat to Aytu BioPharma's product Tuzistra XR, which contains codeine.

AI Analysis | Feedback

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Aytu BioPharma (AYTU) operates in several addressable markets with its main products:

  • ADHD Products (Adzenys XR-ODT, Cotempla XR-ODT, Adzenys ER): The U.S. ADHD therapeutics market was valued at approximately $9.89 billion in 2023 and is projected to reach $12.56 billion by 2030. The global attention deficit hyperactivity disorder market was valued at $15.8 billion in 2023 and is estimated to grow to $24.6 billion by 2032. Specifically, Cotempla XR-ODT accounted for an estimated 3-4% of the global ADHD pharmacotherapy market, valued at around $400-500 million in 2022.
  • Karbinal ER (seasonal and perennial allergies): The global antihistamine drugs market size was $336.08 billion in 2025 and is expected to reach $666.15 billion by 2033. The global allergy rhinitis drugs market is expected to reach $21.61 billion by 2035. The U.S. market for carbinoxamine maleate is considered robust due to the high prevalence of seasonal allergies.
  • Poly-Vi-Flor and Tri-Vi-Flor (fluoride deficiency): The global dental fluoride treatment market size was estimated at $14.11 billion in 2024 and is projected to grow to $21.0 billion by the end of 2031. The North America dental fluoride treatment market was valued at $4.1 billion in 2024, representing 36.9% of the global market.
  • Tuzistra XR (antitussive): The U.S. cough and cold prescription market is valued in excess of $3 billion, with 30-35 million prescriptions written annually. The global antitussive drugs market size was approximately $1.44 billion in 2024 and is predicted to reach around $2.31 billion by 2034. North America accounts for approximately 35-38% of the global antitussive drugs market.
  • ZolpiMist (insomnia): The U.S. non-benzodiazepine prescription sleep aid category is a $1.8 billion market with over 43 million prescriptions annually. The U.S. insomnia market was nearly $4.73 billion in 2023. Globally, the insomnia treatment market size was $3.85 billion in 2024 and is expected to grow to $6.63 billion by 2033.
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AI Analysis | Feedback

Here are 3-5 expected drivers of future revenue growth for Aytu BioPharma (AYTU) over the next 2-3 years:

  1. Commercialization and Market Penetration of EXXUA: The successful launch and subsequent market penetration of EXXUA (gepirone) for Major Depressive Disorder (MDD) is anticipated to be a primary driver of revenue growth. EXXUA was launched in the fourth quarter of calendar 2025 and is considered the centerpiece of the company's commercial efforts, expected to significantly contribute to growth by late fiscal 2026. Aytu BioPharma is actively focusing on driving prescriber adoption and long-term brand growth for this product.
  2. Unique Clinical Profile of EXXUA: EXXUA's distinct clinical profile, particularly the absence of reported sexual dysfunction and no clinically significant weight gain in clinical trials, differentiates it from many existing antidepressant treatments. This unique selling proposition is expected to be a key factor in driving adoption among the estimated 21 million Americans suffering from MDD, positioning EXXUA to capture market share in the over $22 billion U.S. prescription MDD market.
  3. Continued Contribution from ADHD Portfolio: Despite a shift in marketing focus towards EXXUA, the company's ADHD portfolio, including Adzenys XR-ODT and Cotempla XR-ODT, remains a significant revenue generator. In the second quarter of fiscal 2026, the ADHD portfolio contributed $13.2 million in net revenue. While total prescriptions decreased due to reduced marketing efforts, this was partially offset by product price increases and improved gross-to-nets, indicating potential for continued revenue generation from this established portfolio.

AI Analysis | Feedback

Share Issuance

  • Aytu BioPharma had 11 million shares outstanding in Q2 2026 (ended December 31, 2025), representing an 8.3% increase from the prior quarter.
  • In April 2025, the company completed an upsized "At the Market Public Offering of Common Stock," which included the full exercise of overallotment.
  • The merger with Neos Therapeutics in March 2021 resulted in Neos stockholders owning approximately 30% of the fully diluted common shares of Aytu.

Inbound Investments

  • Stonepine Capital Management, LLC increased its investment in Aytu BioPharma by acquiring 626,862 shares in September 2024, bringing its ownership to 9.99% of the company.
  • AWM Investment Company, Inc. reported beneficial ownership of 619,574 shares, or 5.8% of AYTU common stock, as of December 31, 2025.
  • Over the last 24 months, institutional investors collectively purchased approximately $4.25 million worth of Aytu BioPharma shares.

Outbound Investments

  • Aytu BioPharma completed a merger/acquisition with Rumpus Therapeutics on April 12, 2021.
  • The company strategically wound down and sold its Consumer Health business to focus on its core prescription pharmaceutical portfolio.

Capital Expenditures

  • Aytu BioPharma reported capital expenditures of $17,000 in Q2 2026 (ended December 31, 2025).
  • In a recent quarter (Q2 2026), capital expenditures were noted as $228,000.
  • Strategic realignments have included exiting research and development and closing a manufacturing facility, indicating a focus on optimizing or reducing capital expenditures in these areas.

Better Bets vs. Aytu BioPharma (AYTU)

Latest Trefis Analyses

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Trade Ideas

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Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

AYTUAXSMSUPNASRTCPIXPBHMedian
NameAytu Bio.Axsome T.Supernus.Assertio Cumberla.Prestige. 
Mkt Price2.57223.0649.1922.164.5555.7535.67
Mkt Cap0.011.42.80.10.12.71.4
Rev LTM63708719119451,104413
Op Inc LTM-0-177-37-17-3335-10
FCF LTM-4-7146-284267-0
FCF 3Y Avg1-1281091632499
CFO LTM-1-7147-2852772
CFO 3Y Avg2-12711016325810

Growth & Margins

AYTUAXSMSUPNASRTCPIXPBHMedian
NameAytu Bio.Axsome T.Supernus.Assertio Cumberla.Prestige. 
Rev Chg LTM2.0%63.9%8.6%-5.0%17.6%-1.3%5.3%
Rev Chg 3Y Avg-14.8%69.9%2.9%-8.5%2.5%-0.1%1.2%
Rev Chg Q-6.5%57.4%21.5%-57.9%31.1%-2.4%9.6%
QoQ Delta Rev Chg LTM-1.7%10.9%5.5%-13.6%7.9%-0.6%2.4%
Op Inc Chg LTM81.5%26.2%-148.8%8.3%56.6%1.3%17.2%
Op Inc Chg 3Y Avg69.9%-13.6%81.4%-93.7%7.3%-0.1%3.6%
Op Mgn LTM-0.7%-24.9%-5.1%-14.5%-6.3%30.3%-5.7%
Op Mgn 3Y Avg-3.0%-59.3%2.8%-6.3%-15.8%30.2%-4.7%
QoQ Delta Op Mgn LTM-2.5%1.6%-0.9%-2.2%1.6%-0.7%-0.8%
CFO/Rev LTM-0.9%-10.0%6.6%-23.7%11.1%25.1%2.8%
CFO/Rev 3Y Avg2.3%-38.0%16.9%10.0%8.3%23.1%9.1%
FCF/Rev LTM-5.9%-10.0%6.4%-23.7%8.1%24.2%0.3%
FCF/Rev 3Y Avg0.6%-38.2%16.8%10.0%6.8%22.3%8.4%

Valuation

AYTUAXSMSUPNASRTCPIXPBHMedian
NameAytu Bio.Axsome T.Supernus.Assertio Cumberla.Prestige. 
Mkt Cap0.011.42.80.10.12.71.4
P/S0.416.13.91.21.52.42.0
P/Op Inc-62.5-64.7-76.6-8.3-23.78.0-43.1
P/EBIT-1.2-62.2-57.6-5.2-28.68.7-16.9
P/E-1.1-60.6-73.2-4.7-23.414.3-14.0
P/CFO-43.4-161.559.7-5.013.49.62.3
Total Yield-94.8%-1.6%-1.4%-21.3%-4.3%7.0%-3.0%
Dividend Yield0.0%0.0%0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg10.0%-2.7%5.7%10.7%8.7%7.7%8.2%
D/E0.80.00.00.30.20.40.2
Net D/E-0.4-0.0-0.1-0.2-0.00.4-0.1

Returns

AYTUAXSMSUPNASRTCPIXPBHMedian
NameAytu Bio.Axsome T.Supernus.Assertio Cumberla.Prestige. 
1M Rtn-4.1%32.4%-2.6%15.4%43.5%6.2%10.8%
3M Rtn-1.9%19.1%1.6%84.8%20.1%-13.5%10.3%
6M Rtn20.7%65.3%-13.7%103.7%71.1%-7.9%43.0%
12M Rtn97.7%91.5%51.9%143.1%1.8%-32.8%71.7%
3Y Rtn68.0%202.5%34.0%-76.0%163.0%-8.2%51.0%
1M Excs Rtn-13.2%21.6%-12.5%5.3%37.0%-8.7%-1.7%
3M Excs Rtn-6.8%14.1%-3.3%79.9%15.1%-18.4%5.4%
6M Excs Rtn7.1%59.1%-16.9%92.3%46.0%-14.1%26.6%
12M Excs Rtn68.5%71.1%22.1%99.7%-26.5%-61.4%45.3%
3Y Excs Rtn-64.7%137.7%-40.7%-147.3%92.0%-83.5%-52.7%

Comparison Analyses

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FDA Approved Drugs Data

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Post-Approval Fwd Returns
FDA
App #
Brand
Name
Generic
Name
Dosage
Form
FDA
Approval
3M
Rtn
6M
Rtn
1Y
Rtn
2Y
Rtn
Total
Rtn
NDA022556  KARBINAL ERcarbinoxamine maleatesuspension, extended release3282013     
NDA204736  ACIPHEX SPRINKLErabeprazole sodiumcapsule, delayed release3262013     
NDA022196  ZOLPIMISTzolpidem tartratespray, metered12192008     

Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Attention Deficit Hyperactivity Disorder (ADHD) Portfolio58    
Pediatric Portfolio7    
Other0    
Consumer Health 34  10
Rx 74  17
Total65107  28


Price Behavior

Price Behavior
Market Price$2.57 
Market Cap ($ Bil)0.0 
First Trading Date10/20/2017 
Distance from 52W High-11.4% 
   50 Days200 Days
DMA Price$2.58$2.40
DMA Trendupup
Distance from DMA-0.5%7.2%
 3M1YR
Volatility44.2%114.9%
Downside Capture0.640.79
Upside Capture81.60188.62
Correlation (SPY)36.5%14.2%
AYTU Betas & Captures as of 4/30/2026

 1M2M3M6M1Y3Y
Beta1.360.891.120.871.240.83
Up Beta1.601.401.441.370.200.32
Down Beta3.480.300.760.360.580.73
Up Capture18%67%97%102%345%114%
Bmk +ve Days15223166141428
Stock +ve Days9192863119338
Down Capture409%95%120%74%129%106%
Bmk -ve Days4183056108321
Stock -ve Days12213155116369

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with AYTU
AYTU91.7%114.9%0.96-
Sector ETF (XLV)6.8%15.7%0.2314.1%
Equity (SPY)27.8%12.5%1.7314.2%
Gold (GLD)40.6%27.2%1.236.5%
Commodities (DBC)50.1%18.0%2.16-5.1%
Real Estate (VNQ)11.0%13.4%0.5311.7%
Bitcoin (BTCUSD)-17.3%42.2%-0.3410.8%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with AYTU
AYTU-55.1%85.6%-0.57-
Sector ETF (XLV)5.2%14.6%0.1812.9%
Equity (SPY)12.8%17.1%0.5918.0%
Gold (GLD)20.2%17.9%0.922.2%
Commodities (DBC)14.0%19.1%0.601.3%
Real Estate (VNQ)3.4%18.8%0.0914.8%
Bitcoin (BTCUSD)7.9%56.2%0.358.3%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with AYTU
AYTU-59.8%194.6%-0.13-
Sector ETF (XLV)9.2%16.5%0.457.6%
Equity (SPY)14.9%17.9%0.7111.6%
Gold (GLD)13.4%15.9%0.70-1.2%
Commodities (DBC)9.6%17.7%0.456.4%
Real Estate (VNQ)5.6%20.7%0.237.0%
Bitcoin (BTCUSD)67.4%66.9%1.06-1.1%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date4152026
Short Interest: Shares Quantity0.5 Mil
Short Interest: % Change Since 3312026-0.2%
Average Daily Volume0.0 Mil
Days-to-Cover Short Interest13.6 days
Basic Shares Quantity10.0 Mil
Short % of Basic Shares5.0%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
2/3/2026-10.3%-11.8%-1.0%
9/23/2025-17.9%-25.1%-9.6%
5/14/202591.9%49.6%44.4%
2/12/2025-0.7%-0.7%-13.3%
9/26/2024-17.2%-15.8%-24.0%
5/15/2024-3.3%2.0%-6.9%
2/14/2024-1.0%-6.0%-8.9%
9/27/202339.1%54.2%51.6%
...
SUMMARY STATS   
# Positive675
# Negative121113
Median Positive10.2%16.2%2.1%
Median Negative-7.1%-9.9%-13.3%
Max Positive91.9%54.2%51.6%
Max Negative-17.9%-25.1%-27.7%

SEC Filings

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Report DateFiling DateFiling
12/31/202502/03/202610-Q
09/30/202511/13/202510-Q
06/30/202509/23/202510-K
03/31/202505/14/202510-Q
12/31/202402/12/202510-Q
09/30/202411/13/202410-Q
06/30/202409/26/202410-K
03/31/202405/15/202410-Q
12/31/202302/14/202410-Q
09/30/202311/14/202310-Q
06/30/202310/12/202310-K
03/31/202305/11/202310-Q
12/31/202202/21/202310-Q
09/30/202211/14/202210-Q
06/30/202209/27/202210-K
03/31/202205/16/202210-Q

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Disbrow, JarrettChief Business OfficerDirectBuy61020251.5016,66624,99944,193Form
2Disbrow, Joshua RChief Executive OfficerDirectBuy61020251.5066,66699,999229,886Form