Alector (ALEC)


Market Price (9/3/2026): $2.77 | Market Cap: $308.1 MilSector: Health Care | Industry: Biotechnology

Alector (ALEC)


Market Price (9/3/2026): $2.77
Market Cap: $308.1 Mil
Sector: Health Care
Industry: Biotechnology

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0

Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -46%

Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Neurodegenerative Disease Therapeutics, Show more.

Weak multi-year price returns
2Y Excs Rtn is -85%, 3Y Excs Rtn is -125%

Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -126 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -912%

Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -83%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -27%, Rev Chg QQuarterly Revenue Change % is -58%

Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 121%

Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1141%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1143%

Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 69%

Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -43%

Key risks
ALEC key risks include [1] the recent clinical failure of its lead late-stage drug, Show more.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -46%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Neurodegenerative Disease Therapeutics, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -85%, 3Y Excs Rtn is -125%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -126 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -912%
4 Weak revenue growth
Rev Chg LTMRevenue Change % Last Twelve Months (LTM) is -83%, Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -27%, Rev Chg QQuarterly Revenue Change % is -58%
5 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 121%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -1141%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -1143%
7 Valuation getting more expensive
P/S 6M Chg %Price/Sales change over 6 months. Declining P/S indicates valuation has become less expensive. is 69%
8 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -43%
9 Key risks
ALEC key risks include [1] the recent clinical failure of its lead late-stage drug, Show more.

ALEC in ETFs

Weight = ALEC's share of each fund

VTI0.00%
IWM0.01%
IWO0.01%
VTWO0.00%
SCHA0.00%
IWN0.00%
VHT0.00%
SCHB0.00%
+1 more covered ETF

Valuation & Metrics

Price Chart

Why The Stock Moved

Qualitative Assessment

AI Analysis | Feedback

Updated on 9/2/2026

Alector (ALEC) stock has gained about 25% since 5/31/2026 because of the following key factors:

1. Alector's fiscal Q2 2026 earnings, reported on August 6, 2026, significantly surpassed analyst expectations. The company posted a net loss of $0.21 per share, which was better than the consensus estimate of a $0.23 loss. Additionally, collaboration revenue reached $3.3 million, considerably exceeding analyst forecasts that ranged between $1.4 million and $1.7 million. This positive earnings surprise led to an approximate 23% single-session stock increase following the announcement.

2. Positive advancements in Alector's proprietary Alector Brain Carrier (ABC) platform contributed to investor confidence. The company designated AL137 as its lead ABC-enabled anti-amyloid beta antibody for Alzheimer's disease, with an Investigational New Drug (IND) filing targeted for fiscal Q1 2027 (ending December 2026) and first-in-human dosing in Australia no later than April 2027. This progress in its wholly-owned preclinical pipeline, especially following the termination of the GSK collaboration, signaled continued strategic execution and potential future value.

Show more
Updated on 9/2/2026

Alector (ALEC) stock has gained about 25% since 5/31/2026 because of the following key factors:

1. Alector's fiscal Q2 2026 earnings, reported on August 6, 2026, significantly surpassed analyst expectations. The company posted a net loss of $0.21 per share, which was better than the consensus estimate of a $0.23 loss. Additionally, collaboration revenue reached $3.3 million, considerably exceeding analyst forecasts that ranged between $1.4 million and $1.7 million. This positive earnings surprise led to an approximate 23% single-session stock increase following the announcement.

2. Positive advancements in Alector's proprietary Alector Brain Carrier (ABC) platform contributed to investor confidence. The company designated AL137 as its lead ABC-enabled anti-amyloid beta antibody for Alzheimer's disease, with an Investigational New Drug (IND) filing targeted for fiscal Q1 2027 (ending December 2026) and first-in-human dosing in Australia no later than April 2027. This progress in its wholly-owned preclinical pipeline, especially following the termination of the GSK collaboration, signaled continued strategic execution and potential future value.

3. Strategic cost reductions and a robust cash runway, as reported in fiscal Q2 2026, provided financial stability. Alector successfully reduced research and development expenses to $19.5 million from $27.6 million year-over-year and general and administrative expenses to $8.3 million from $14.4 million year-over-year, largely due to prior workforce reductions. The company also confirmed a cash, cash equivalents, and investments balance of $172.8 million as of June 30, 2026, which management projects will fund operations at least through 2027.

4. Following the strong Q2 2026 results, industry analysts upgraded their fiscal year 2026 revenue forecasts. Analysts increased their consensus revenue estimates by 60%, raising the forecast from approximately $6.86 million to $11.0 million, and also adjusted price targets upward. This revised positive outlook reflected improved sentiment regarding Alector's financial prospects and pipeline potential.

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Stock Movement Drivers

Fundamental Drivers

The 25.9% change in ALEC stock from 5/31/2026 to 9/2/2026 was primarily driven by a 68.3% change in the company's P/S Multiple.
(LTM values as of)53120269022026Change
Stock Price ($)2.162.7225.9%
Change Contribution By: 
Total Revenues ($ Mil)1814-24.7%
P/S Multiple13.021.868.3%
Shares Outstanding (Mil)111111-0.6%
Cumulative Contribution25.9%

LTM = Last Twelve Months as of date shown

Market Drivers

5/31/2026 to 9/2/2026
ReturnCorrelation
ALEC25.9% 
Market (SPY)1.1%16.6%
Sector (XLV)15.7%20.0%

Fundamental Drivers

The 11.9% change in ALEC stock from 2/28/2026 to 9/2/2026 was primarily driven by a 72.5% change in the company's P/S Multiple.
(LTM values as of)22820269022026Change
Stock Price ($)2.432.7211.9%
Change Contribution By: 
Total Revenues ($ Mil)2114-34.1%
P/S Multiple12.721.872.5%
Shares Outstanding (Mil)110111-1.5%
Cumulative Contribution11.9%

LTM = Last Twelve Months as of date shown

Market Drivers

2/28/2026 to 9/2/2026
ReturnCorrelation
ALEC11.9% 
Market (SPY)11.8%22.0%
Sector (XLV)8.4%29.2%

Fundamental Drivers

The 15.7% change in ALEC stock from 8/31/2025 to 9/2/2026 was primarily driven by a 650.6% change in the company's P/S Multiple.
(LTM values as of)83120259022026Change
Stock Price ($)2.352.7215.7%
Change Contribution By: 
Total Revenues ($ Mil)8114-82.9%
P/S Multiple2.921.8650.6%
Shares Outstanding (Mil)100111-9.8%
Cumulative Contribution15.7%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2025 to 9/2/2026
ReturnCorrelation
ALEC15.7% 
Market (SPY)19.6%24.3%
Sector (XLV)27.5%20.4%

Fundamental Drivers

The -50.1% change in ALEC stock from 8/31/2023 to 9/2/2026 was primarily driven by a -86.4% change in the company's Total Revenues ($ Mil).
(LTM values as of)83120239022026Change
Stock Price ($)5.452.72-50.1%
Change Contribution By: 
Total Revenues ($ Mil)10214-86.4%
P/S Multiple4.521.8389.4%
Shares Outstanding (Mil)83111-24.9%
Cumulative Contribution-50.1%

LTM = Last Twelve Months as of date shown

Market Drivers

8/31/2023 to 9/2/2026
ReturnCorrelation
ALEC-50.1% 
Market (SPY)75.9%28.1%
Sector (XLV)35.9%27.1%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
ALEC Return36%-55%-14%-76%-17%54%-84%
Peers Return-35%-18%22%-29%14%24%-35%
S&P 500 Return27%-19%24%23%16%11%103%

Monthly Win Rates [3]
ALEC Win Rate50%33%50%25%50%56% 
Peers Win Rate47%39%44%36%56%52% 
S&P 500 Win Rate75%42%67%75%67%44% 

Max Drawdowns [4]
ALEC Max Drawdown-51%-67%-62%-79%-66%-49% 
Peers Max Drawdown-55%-44%-40%-45%-36%-20% 
S&P 500 Max Drawdown-5%-25%-10%-8%-19%-9% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: DNLI, BIIB, ACAD.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 9/2/2026 (YTD)

How Low Can It Go

EventALECS&P 500
2025 US Tariff Shock
  % Loss-50.6%-18.8%
  % Gain to Breakeven102.4%23.1%
  Time to Breakeven120 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-39.5%-9.5%
  % Gain to Breakeven65.3%10.5%
  Time to Breakeven28 days24 days
2020 COVID-19 Crash
  % Loss-29.4%-33.7%
  % Gain to Breakeven41.6%50.9%
  Time to Breakeven62 days140 days

Compare to DNLI, BIIB, ACAD

In The Past

Alector's stock fell -50.6% during the 2025 US Tariff Shock. Such a loss loss requires a 102.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

EventALECS&P 500
2025 US Tariff Shock
  % Loss-50.6%-18.8%
  % Gain to Breakeven102.4%23.1%
  Time to Breakeven120 days79 days
Summer-Fall 2023 Five Percent Yield Shock
  % Loss-39.5%-9.5%
  % Gain to Breakeven65.3%10.5%
  Time to Breakeven28 days24 days
2020 COVID-19 Crash
  % Loss-29.4%-33.7%
  % Gain to Breakeven41.6%50.9%
  Time to Breakeven62 days140 days

Compare to DNLI, BIIB, ACAD

In The Past

Alector's stock fell -50.6% during the 2025 US Tariff Shock. Such a loss loss requires a 102.4% gain to breakeven.

Preserve Wealth

Limiting losses and compounding gains is essential to preserving wealth.

Asset Allocation

Actively managed asset allocation strategies protect wealth. Learn more.

About Alector (ALEC)

Alector, Inc. (ALEC) is a clinical-stage biopharmaceutical company dedicated to discovering and developing therapies for a range of neurodegenerative diseases. Headquartered in South San Francisco, California, the company focuses on addressing conditions that currently have limited treatment options, aiming to bring innovative medicines to patients in need.

The company's pipeline features several key product candidates targeting significant unmet medical needs. Its most advanced program, AL001, is a humanized monoclonal antibody currently in Phase III clinical trials for Frontotemporal Dementia (FTD), Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis (ALS). Other notable candidates include AL101 (Phase I for Alzheimer's and Parkinson's), AL002 (Phase II for Alzheimer's), and AL003 (Phase I for Alzheimer's). Alector also has AL044 in development, which targets a risk gene for Alzheimer's disease.

Alector's primary market encompasses patients suffering from severe neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, FTD, and ALS. To accelerate its development and commercialization efforts, Alector has established strategic collaboration agreements, most notably with GlaxoSmithKline plc for the development and commercialization of monoclonal antibodies such as AL001 and AL101, allowing it to leverage broader resources and expertise.

AI Analysis | Feedback

Here are 1-3 brief analogies for Alector:

  • Like a startup Biogen, focused on antibody treatments for neurodegenerative diseases.
  • Like Amgen or Genentech, but still in the clinical trial phase, developing antibody drugs for conditions like Alzheimer's.

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  • AL001: A humanized recombinant monoclonal antibody in Phase III clinical trials for frontotemporal dementia, Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis.
  • AL101: A therapy in Phase I clinical trials for neurodegenerative diseases, including Alzheimer's and Parkinson's.
  • AL002: A product candidate in Phase II clinical trials for Alzheimer's disease.
  • AL003: A product candidate in Phase I clinical trials for Alzheimer's disease.
  • AL044: A development-stage therapy targeting MS4A4A, a risk gene for Alzheimer's disease.

AI Analysis | Feedback

Alector (ALEC) is a clinical-stage biopharmaceutical company. At this stage, its revenue primarily comes from collaboration agreements with larger pharmaceutical companies for research, development, and potential commercialization of its drug candidates. Therefore, its major "customers" or financial partners are other companies.

  • GlaxoSmithKline plc (symbol: GSK)
  • Adimab, LLC

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Adimab, LLC

GlaxoSmithKline plc (GSK)

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Arnon Rosenthal, Ph.D., Co-Founder, Chief Executive Officer, and Director

Dr. Rosenthal co-founded Alector in 2013 and has served as its Chief Executive Officer and a member of its Board of Directors since then. He previously co-founded Annexon Biosciences, Inc., where he served as acting Chief Executive Officer and later as Chairman. Dr. Rosenthal also co-founded Rinat Neuroscience Corporation, which discovered and developed the migraine drug Ajovy and was acquired by Pfizer Inc. in 2006. Before his entrepreneurial ventures, he held various roles at Genentech, Inc., ultimately serving as Staff Scientist, where his team discovered the target for the cancer drug Erivedge. He holds a Ph.D. in biology from the Hebrew University of Jerusalem.

Neil Berkley, M.B.A., Chief Financial Officer and Chief Business Officer

Mr. Berkley joined Alector in March 2024 as Chief Business Officer and assumed the role of Interim CFO in June 2025, with his current title listed as Chief Financial Officer and Chief Business Officer. Prior to Alector, he served as Chief Corporate Development Officer at Juvena Therapeutics, Chief Business Officer at AbCellera, and Vice President and Head of Business Development at Halozyme Therapeutics. His career also includes leadership roles at Cadence Pharmaceuticals, Acadia, and GSK. He holds a B.S. in Molecular Biology from the University of California, San Diego, and an M.S. and an M.B.A.

Giacomo Salvadore, M.D., Chief Medical Officer

Dr. Salvadore was appointed Chief Medical Officer effective April 25, 2025, having joined Alector in 2023 as Senior Vice President of Clinical Development. He leads Alector's global clinical development strategy for its late-stage clinical and research portfolios. Dr. Salvadore brings over 15 years of industry experience in leading clinical development for neurology and psychiatry programs.

Hua Long, PhD, DABT, Senior Vice President and Head of Research

Dr. Long leads Alector's research and preclinical organization. In this role, she oversees discovery, nonclinical science, and translational research to advance therapies for neurodegenerative diseases.

Danielle Pasqualone, Ph. D., J.D., General Counsel

Dr. Pasqualone joined Alector in 2019 as the Vice President of Intellectual Property and now serves as General Counsel. She is responsible for overseeing the company's legal function, directing global intellectual property strategy, and providing legal counsel on various transactions, including collaborations.

AI Analysis | Feedback

The key risks for Alector (ALEC) are primarily related to the inherent challenges of being a clinical-stage biopharmaceutical company focused on neurodegenerative diseases.

  1. Clinical Trial Failure and Regulatory Approval: As a clinical-stage company, Alector's success is entirely dependent on its product candidates successfully navigating and demonstrating safety and efficacy in ongoing and future clinical trials (Phase I, II, and III). A significant portion of drug candidates fail at various stages of clinical development, especially in late-stage trials, or fail to receive regulatory approval from health authorities, which would prevent the company from commercializing its therapies.
  2. High Development Risk for Neurodegenerative Diseases: Alector's pipeline is focused on neurodegenerative diseases such as Frontotemporal Dementia, Alzheimer's, Parkinson's, and Amyotrophic Lateral Sclerosis. Historically, drug development for these complex neurological conditions has a high rate of failure, presenting significant challenges in demonstrating clinical benefit and safety.
  3. Reliance on Strategic Collaborations: Alector has strategic collaboration agreements, notably with GlaxoSmithKline plc for the development and commercialization of key monoclonal antibodies like AL001 and AL101. The success of these programs, and potentially the company's financial stability, could be impacted by the ongoing commitment, resources, or strategic direction of its partners, or by the termination of such agreements.

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Addressable Markets for Alector's Main Products

  • Frontotemporal Dementia (FTD): The global market for frontotemporal dementia is projected to increase from $3.25 billion in 2025 to $3.53 billion in 2026, growing at a compound annual growth rate (CAGR) of 8.8%. It is expected to reach $4.99 billion by 2030.
  • Alzheimer's Disease: The global Alzheimer's disease market is estimated at $12.4 billion in 2025 and is projected to reach $29.4 billion by 2035, representing a CAGR of 9%.
  • Parkinson's Disease: The global Parkinson's disease drugs market size is projected to grow from $7.75 billion in 2025 to $15.77 billion by 2034, at a CAGR of 8.22%.
  • Amyotrophic Lateral Sclerosis (ALS): The global Amyotrophic Lateral Sclerosis market is estimated to be valued at $835.8 million in 2025 and is projected to reach $1496.9 million by 2035, with a compound annual growth rate (CAGR) of 6.0%.

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Expected Drivers of Future Revenue Growth for Alector (ALEC)

Over the next two to three years, Alector's future revenue growth is anticipated to be driven by the following key factors:

  1. Advancement and Potential Commercialization of AL101 (Nivisnebart): The progression of AL101, developed in collaboration with GlaxoSmithKline (GSK), through its ongoing Phase 2 PROGRESS-AD clinical trial for early Alzheimer's disease is a significant driver. Positive results from the interim futility analysis expected in the first half of 2026 and subsequent advancement into later-stage clinical development could trigger substantial milestone payments from GSK and pave the way for future product revenue upon commercialization.
  2. Development and Clinical Entry of Alector Brain Carrier (ABC) Platform Programs: Alector's proprietary Alector Brain Carrier (ABC) platform, designed to enhance the delivery of therapeutics across the blood-brain barrier, represents a strategic focus for future growth. The planned Investigational New Drug (IND) submissions for lead ABC-enabled candidates, such as AL137 for Alzheimer's disease in late 2026-early 2027 and AL050 for Parkinson's disease in 2027, are expected to generate future milestone payments or lead to new collaboration agreements.
  3. Milestone Payments from the Strategic Collaboration with GlaxoSmithKline (GSK): The existing strategic collaboration agreement with GSK provides a framework for significant potential revenue. This includes up to $1.5 billion in clinical development, regulatory, and commercial launch-related milestone payments for partnered programs. The continued progression of AL101 within this collaboration is crucial for realizing these milestone payments.

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Share Issuance

  • In January 2024, Alector completed an underwritten public offering of 10,869,566 shares of its common stock, generating gross proceeds of $75 million.
  • In January 2020, Alector completed an upsized underwritten public offering of 8,350,000 shares of common stock at $25.00 per share, resulting in gross proceeds of $208,750,000.

Inbound Investments

  • In July 2021, Alector entered a strategic global collaboration with GlaxoSmithKline (GSK) for the development and commercialization of AL001 and AL101. As part of this agreement, Alector received $700 million in upfront payments and is eligible for up to an additional $1.5 billion in potential milestone payments.
  • In November 2024, Alector secured a $50 million credit facility from Hercules Capital to boost its financial flexibility and advance its pipeline.

Capital Expenditures

  • Alector reported capital expenditures of -$1 (likely referring to $1 million, given the context of other financial figures in millions) in a recent financial summary.
  • Research and development expenses for the full year 2025 were $123.1 million, a decrease from $185.9 million in 2024, reflecting a significant portion of capital deployed towards its drug pipeline.
  • The primary focus of ongoing capital deployment and R&D is the Alector Brain Carrier (ABC) platform and its lead candidates, AL137 and AL050, targeting Investigational New Drug (IND) submissions in 2026 and 2027, respectively.

Better Bets vs. Alector (ALEC)

Peer Outperformance in Biotechnology

ALEC has trailed 62% of its 362 Biotechnology peers over 5Y. Biotechnology ranks 9th of 10 industries in Health Care by median 5Y return. The sector’s gains have largely come from elsewhere.
Share of Biotechnology constituents that ALEC has outperformed, by holding period. Peers without a full price history over a given window are excluded from that window.
1Y
49%
of 457 industry peers · 5.0% return
3Y
41%
of 404 industry peers · -51.2% return
5Y
38%
of 362 industry peers · -89.8% return
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Median price return by industry across the Health Care sector, ranked by 5Y. Biotechnology is ALEC's own industry. Use this to see which corners of the sector have carried the returns.
Industry Names 1Y med3Y med5Y med Top 3 by 5Y
Health Care Distributors 7 14.9%97.1%148.9% CAH 410% · MCK 359% · COR 183%
Managed Health Care 8 32.0%3.1%3.9% OSCR 67% · HQY 52% · ELV 15%
Health Care Services 20 19.8%49.6%-0.6% HIMS 249% · RDNT 140% · DGX 70%
Health Care Facilities 24 2.8%-5.4%-20.1% NHC 242% · THC 241% · ENSG 111%
Health Care Equipment 50 -0.5%-6.4%-23.3% POCI 11025% · UFPT 323% · GKOS 204%
Health Care Supplies 12 33.0%-15.3%-34.7% LNTH 271% · HAE 59% · MMSI 23%
Pharmaceuticals 63 2.3%3.2%-35.1% LQDA 2443% · INDV 1152% · ETON 1089%
Life Sciences Tools & Services 109 0.8%-32.0%-73.6% SNWV 1716% · MEDP 204% · AXGN 178%
Biotechnology ← 363 8.7%-27.2%-76.5% BRTX 100750% · DNTH 1529% · CELZ 1514%
Health Care Technology 20 -22.3%-58.7%-78.1% SPOK 66% · HSTM 0% · VEEV -12%
Median of constituents with a full price history over each window. Top names are unfiltered by size in this render.

Recent Active Movers

Peer Comparisons

Peers to compare with:

Financials

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Mkt Price2.7222.85222.6728.9325.89
Mkt Cap0.34.332.95.04.6
Rev LTM14410,0281,139576
Op Inc LTM-126-5431,93586-20
FCF LTM-158-4682,49051-54
FCF 3Y Avg-197-4131,93573-62
CFO LTM-158-4342,8791601
CFO 3Y Avg-197-3922,260143-27

Growth & Margins

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Rev Chg LTM-82.9%-0.3%11.8%0.3%
Rev Chg 3Y Avg-27.3%-0.2%29.3%0.2%
Rev Chg Q-57.8%-3.4%16.4%3.4%
QoQ Delta Rev Chg LTM-24.7%-0.9%4.0%0.9%
Op Inc Chg LTM6.0%-1.7%-21.7%-4.4%-3.0%
Op Inc Chg 3Y Avg4.9%-71.0%-6.0%136.4%-0.5%
Op Mgn LTM-912.4%-15,058.2%19.3%7.6%-452.4%
Op Mgn 3Y Avg-472.4%-21.5%6.3%6.3%
QoQ Delta Op Mgn LTM-172.7%--3.9%0.2%-3.9%
CFO/Rev LTM-1,141.4%-12,043.3%28.7%14.1%-563.7%
CFO/Rev 3Y Avg-599.8%-22.8%13.9%13.9%
FCF/Rev LTM-1,142.6%-12,975.4%24.8%4.5%-569.0%
FCF/Rev 3Y Avg-601.0%-19.5%7.4%7.4%

Valuation

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Mkt Cap0.34.332.95.04.6
P/S21.81,187.63.34.413.1
P/Op Inc-2.4-7.917.057.57.3
P/EBIT-2.4-7.925.457.511.5
P/E-2.6-8.439.413.05.2
P/CFO-1.9-9.911.431.04.8
Total Yield-39.0%-11.9%2.5%7.7%-4.7%
Dividend Yield0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-91.4%-11.8%7.4%2.2%-4.8%
D/E0.10.00.30.00.1
Net D/E-0.5-0.20.2-0.2-0.2

Returns

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
1M Rtn80.1%-1.3%10.3%13.0%11.6%
3M Rtn53.2%16.2%13.6%35.0%25.6%
6M Rtn26.5%12.2%17.2%23.7%20.5%
12M Rtn5.0%47.9%59.5%12.6%30.3%
3Y Rtn-51.2%-2.0%-16.7%4.1%-9.3%
1M Excs Rtn77.5%-4.6%7.7%7.5%7.6%
3M Excs Rtn51.7%14.7%12.1%33.5%24.1%
6M Excs Rtn14.9%0.6%5.6%12.1%8.9%
12M Excs Rtn-14.5%28.4%40.0%-6.9%10.8%
3Y Excs Rtn-125.2%-72.6%-88.9%-69.1%-80.8%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20252024202320222021
Single Segment2110197134 
Collaboration revenue    207
Total2110197134207


Operating Income by Segment
$ Mil20252024
Single Segment-156-145
Total-156-145


Price Behavior

Price Behavior
Market Price$2.72 
Market Cap ($ Bil)0.3 
First Trading Date02/07/2019 
Distance from 52W High-18.1% 
   50 Days200 Days
DMA Price$1.86$1.91
DMA Trendindeterminateup
Distance from DMA46.5%42.7%
 3M1YR
Volatility104.8%95.7%
Downside Capture-21.99200.59
Upside Capture181.57163.68
Correlation (SPY)15.9%23.4%
ALEC Betas & Captures as of 8/31/2026

 1M2M3M6M1Y3Y
Beta-1.54-0.041.261.481.771.69
Up Beta-2.75-0.781.151.361.651.23
Down Beta3.042.253.063.292.411.78
Up Capture236%28%72%71%192%489%
Bmk +ve Days10213268138427
Stock +ve Days10172857119368
Down Capture-808%-88%59%115%149%112%
Bmk -ve Days11213259113324
Stock -ve Days10233365114348

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC5.0%95.7%0.54-
Sector ETF (XLV)27.5%16.0%1.3320.4%
Equity (SPY)20.6%12.8%1.1924.3%
Gold (GLD)23.8%29.1%0.7312.7%
Commodities (DBC)41.7%20.4%1.60-13.1%
Real Estate (VNQ)9.7%13.6%0.439.1%
Bitcoin (BTCUSD)-30.7%43.5%-0.7216.1%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC-36.0%84.1%-0.14-
Sector ETF (XLV)6.7%15.1%0.2530.2%
Equity (SPY)12.7%17.2%0.5733.3%
Gold (GLD)19.2%18.8%0.835.8%
Commodities (DBC)10.8%19.5%0.43-1.8%
Real Estate (VNQ)1.9%18.9%-0.0128.4%
Bitcoin (BTCUSD)9.5%52.6%0.3719.6%

Smart multi-asset allocation framework can stack odds in your favor. Learn How
Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC-16.9%84.8%0.10-
Sector ETF (XLV)10.6%16.7%0.5233.0%
Equity (SPY)15.1%17.9%0.7233.8%
Gold (GLD)12.2%16.3%0.614.4%
Commodities (DBC)7.8%18.1%0.355.3%
Real Estate (VNQ)4.8%20.7%0.1927.3%
Bitcoin (BTCUSD)63.0%66.1%1.0315.1%

Smart multi-asset allocation framework can stack odds in your favor. Learn How

Short Interest

Short Interest: As Of Date8142026
Short Interest: Shares Quantity5.9 Mil
Short Interest: % Change Since 73120264.6%
Average Daily Volume1.7 Mil
Days-to-Cover Short Interest3.5 days
Basic Shares Quantity111.2 Mil
Short % of Basic Shares5.3%

Earnings Returns History

Updated 8/17/2026
Expand for More
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/6/2026-2.7%11.5% 
5/7/2026-13.9%-5.7%-32.8%
2/25/20267.1%-10.0%-11.3%
11/6/2025-1.5%-7.7%-1.5%
8/7/202547.3%68.5%89.0%
5/8/202512.5%6.2%38.5%
2/26/2025-3.5%-9.9%-22.7%
11/6/20247.6%-2.2%-58.8%
...
SUMMARY STATS   
# Positive14118
# Negative111416
Median Positive7.6%8.9%14.6%
Median Negative-3.5%-8.8%-12.8%
Max Positive47.3%68.5%89.0%
Max Negative-19.8%-25.2%-58.8%
Collapse to Preview
 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
8/6/2026-2.7%11.5% 
5/7/2026-13.9%-5.7%-32.8%
2/25/20267.1%-10.0%-11.3%
11/6/2025-1.5%-7.7%-1.5%
8/7/202547.3%68.5%89.0%
5/8/202512.5%6.2%38.5%
2/26/2025-3.5%-9.9%-22.7%
11/6/20247.6%-2.2%-58.8%
8/7/20243.9%-1.0%-1.2%
5/8/20240.2%8.9%-16.0%
2/27/2024-0.3%-3.9%-13.3%
11/7/2023-7.3%-25.2%0.9%
8/3/202332.4%15.2%-15.9%
5/4/202310.3%9.5%7.0%
2/28/20233.0%-15.5%-26.1%
11/8/2022-19.8%0.8%1.3%
8/4/202215.3%11.7%-7.7%
5/5/2022-6.5%-14.0%-7.5%
2/24/2022-0.9%-6.1%-10.3%
11/4/20210.8%-9.1%-20.4%
8/3/20217.6%3.9%5.4%
5/5/20218.0%6.9%24.4%
2/25/20212.4%-8.5%-7.9%
11/10/2020-2.0%6.3%22.3%
8/11/2020-5.7%-9.7%-12.4%
SUMMARY STATS   
# Positive14118
# Negative111416
Median Positive7.6%8.9%14.6%
Median Negative-3.5%-8.8%-12.8%
Max Positive47.3%68.5%89.0%
Max Negative-19.8%-25.2%-58.8%

SEC Filings

Expand for More
Report DateFiling DateFiling
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202502/25/202610-K
09/30/202511/06/202510-Q
06/30/202508/07/202510-Q
03/31/202505/08/202510-Q
12/31/202402/26/202510-K
09/30/202411/06/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202302/27/202410-K
09/30/202311/07/202310-Q
06/30/202308/03/202310-Q
03/31/202305/04/202310-Q
12/31/202202/28/202310-K
09/30/202211/08/202210-Q
Collapse to Preview
Report DateFiling DateFiling
06/30/202608/06/202610-Q
03/31/202605/07/202610-Q
12/31/202502/25/202610-K
09/30/202511/06/202510-Q
06/30/202508/07/202510-Q
03/31/202505/08/202510-Q
12/31/202402/26/202510-K
09/30/202411/06/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202302/27/202410-K
09/30/202311/07/202310-Q
06/30/202308/03/202310-Q
03/31/202305/04/202310-Q
12/31/202202/28/202310-K
09/30/202211/08/202210-Q
06/30/202208/04/202210-Q
03/31/202205/05/202210-Q
12/31/202102/24/202210-K
09/30/202111/04/202110-Q
06/30/202108/03/202110-Q
03/31/202105/05/202110-Q
12/31/202002/25/202110-K
09/30/202011/10/202010-Q
06/30/202008/11/202010-Q
03/31/202005/13/202010-Q
12/31/201903/24/202010-K
09/30/201911/12/201910-Q

Insider Activity

Updated 8/21/2026
Expand for More
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Wong-Sarad, GracePrincipal Accounting OfficerDirectSell60320261.883,4756,543179,734Form
2Rosenthal, ArnonChief Executive OfficerDirectSell60320261.9787,216172,1914,673,575Form
3Wong-Sarad, GracePrincipal Accounting OfficerDirectSell60320261.975,70911,271195,319Form
4Berkley, Neil LindsayCFO & Chief Business OfficerDirectSell60320261.9719,36038,221749,999Form
5Wong-Sarad, GracePrincipal Accounting OfficerDirectSell41720262.651,8204,823277,309Form
Collapse to Preview
#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Wong-Sarad, GracePrincipal Accounting OfficerDirectSell60320261.883,4756,543179,734Form
2Rosenthal, ArnonChief Executive OfficerDirectSell60320261.9787,216172,1914,673,575Form
3Wong-Sarad, GracePrincipal Accounting OfficerDirectSell60320261.975,70911,271195,319Form
4Berkley, Neil LindsayCFO & Chief Business OfficerDirectSell60320261.9719,36038,221749,999Form
5Wong-Sarad, GracePrincipal Accounting OfficerDirectSell41720262.651,8204,823277,309Form
6Wong-Sarad, GracePrincipal Accounting OfficerDirectSell31220262.651,0002,650282,132Form
7Wong-Sarad, GracePrincipal Accounting OfficerDirectSell30320262.083,3677,012223,807Form
8Wong-Sarad, GracePrincipal Accounting OfficerDirectSell30320262.128,07117,138235,341Form
9Rosenthal, ArnonChief Executive OfficerDirectSell30320262.1281,864173,8224,964,649Form
10Berkley, Neil LindsayCFO & Chief Business OfficerDirectSell30320262.1229,64962,954731,817Form
11Wong-Sarad, GracePrincipal Accounting OfficerDirectSell22620262.504,07910,198297,258Form
12Wong-Sarad, GracePrincipal Accounting OfficerDirectSell120820251.214,7535,751148,808Form
13Wong-Sarad, GracePrincipal Accounting OfficerDirectSell120320251.128,0569,019142,999Form
14Rosenthal, ArnonChief Executive OfficerDirectSell120320251.12104,347116,8272,709,477Form
15Kenkare-Mitra, SaraPresident and Head of R&DDirectSell120320251.1241,68746,673561,650Form
16Berkley, Neil LindsayChief Bus Ofcr & Interim CFODirectSell120320251.1237,26141,717419,076Form
17Wong-Sarad, GracePrincipal Accounting OfficerDirectSell90420252.505,91014,756258,289Form
18Berkley, Neil LindsayPrincipal Financial OfficerDirectSell90420252.5015,84239,554865,316Form
19Kenkare-Mitra, SaraPresident and Head of R&DDirectSell90420252.5023,63859,0191,356,609Form
20Rosenthal, ArnonChief Executive OfficerDirectSell90420252.5051,562128,7405,868,029Form
21Hammond, PaulaDirectSell82720252.3614,00032,998176,561Form

Investor Activity (13F)

Updated Sep 3, 2026
13F holdings as of Mar 31, 2026 (Q1 2026)

Active managers (13F portfolio over $250M, at least 3 holdings) with a position over $5M that is either over 10% of their portfolio or held in a concentrated book of 50 or fewer total positions. Index/ETF, sovereign, bank, community-bank and charitable/donor-advised filers are excluded.

Active ManagerValue% of PortfolioTotal PositionsQoQFiling
Merck & Co., Inc.$7.6 Mil2.2%14Hold13F
TCG Crossover Management, LLC$21.5 Mil0.6%49Hold13F
Active Manager
Active Manager
Active ManagerValue% of PortfolioTotal PositionsQoQFiling
TCG Crossover Management, LLC$21.5 Mil0.6%49Hold13F
Merck & Co., Inc.$7.6 Mil2.2%14Hold13F
Core Cache Last Updated: 9/2/2026