Tearsheet

Investment Highlights Why It Matters Detailed financial logic regarding cash flow yields vs trend-riding momentum.

0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -127%
Weak multi-year price returns
2Y Excs Rtn is -112%, 3Y Excs Rtn is -152%
Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -124 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -179%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Neurodegenerative Disease Therapeutics, Show more.
  Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -17%, Rev Chg QQuarterly Revenue Change % is -79%
2   Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 46%
3   Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -286%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -286%
4   Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -58%
5   High stock price volatility
Vol 12M is 106%
6   Key risks
ALEC key risks include [1] the recent clinical failure of its lead late-stage drug, Show more.
0 Cash is significant % of market cap
Net D/ENet Debt/Equity. Debt net of cash. Negative indicates net cash. Equity is taken as the Market Capitalization is -127%
1 Megatrend and thematic drivers
Megatrends include Biotechnology & Genomics, Precision Medicine, and Aging Population & Chronic Disease. Themes include Neurodegenerative Disease Therapeutics, Show more.
2 Weak multi-year price returns
2Y Excs Rtn is -112%, 3Y Excs Rtn is -152%
3 Not profitable at operating income level
Op Inc LTMOperating Income, Last Twelve Months is -124 Mil, Op Mgn LTMOperating Margin = Operating Income / Revenue Reflects profitability before taxes and before impact of capital structure (interest payments). is -179%
4 Weak revenue growth
Rev Chg 3Y AvgRevenue Change % averaged over trailing 3 years is -17%, Rev Chg QQuarterly Revenue Change % is -79%
5 Significant share based compensation
SBC/Rev LTMShare Based Compensation / Revenue (Sales), Last Twelve Months (LTM) is 46%
6 Not cash flow generative
CFO/Rev LTMCash Flow from Operations / Revenue (Sales), Last Twelve Months (LTM) is -286%, FCF/Rev LTMFree Cash Flow / Revenue (Sales), Last Twelve Months (LTM) is -286%
7 Yield minus risk free rate is negative
ERPEquity Risk Premium (ERP) = Total Yield - Risk Free Rate, Reflects the premium above risk free assets offered by the investment. is -58%
8 High stock price volatility
Vol 12M is 106%
9 Key risks
ALEC key risks include [1] the recent clinical failure of its lead late-stage drug, Show more.

Valuation, Metrics & Events

Price Chart

Why The Stock Moved

Qualitative Assessment

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Alector (ALEC) stock has lost about 35% since 9/30/2025 because of the following key factors:

1. Failure of Phase 3 INFRONT-3 Clinical Trial for Latozinemab.

Alector's stock significantly declined after the announcement on October 21, 2025, that its pivotal Phase 3 INFRONT-3 clinical trial, evaluating latozinemab for frontotemporal dementia with a progranulin gene mutation (FTD-GRN), did not meet its primary clinical co-endpoints. The trial failed to demonstrate efficacy in slowing disease progression, despite showing a statistically significant effect on plasma progranulin concentrations.

2. Discontinuation of Latozinemab Programs and Workforce Reduction.

Following the unsuccessful trial results, Alector announced the discontinuation of the open-label extension portion of the INFRONT-3 trial and the broader continuation study for latozinemab. The company also implemented substantial operational changes, including a reduction of its workforce by approximately 49% to redirect resources towards its highest-priority remaining programs.

Show more

Stock Movement Drivers

Fundamental Drivers

The -34.5% change in ALEC stock from 9/30/2025 to 1/27/2026 was primarily driven by a -21.3% change in the company's P/S Multiple.
(LTM values as of)93020251272026Change
Stock Price ($)2.961.94-34.5%
Change Contribution By: 
Total Revenues ($ Mil)8169-14.9%
P/S Multiple3.72.9-21.3%
Shares Outstanding (Mil)100103-2.2%
Cumulative Contribution-34.5%

LTM = Last Twelve Months as of date shown

Market Drivers

9/30/2025 to 1/27/2026
ReturnCorrelation
ALEC-34.1% 
Market (SPY)4.4%24.9%
Sector (XLV)11.7%7.0%

Fundamental Drivers

The 38.6% change in ALEC stock from 6/30/2025 to 1/27/2026 was primarily driven by a 83.0% change in the company's P/S Multiple.
(LTM values as of)63020251272026Change
Stock Price ($)1.401.9438.6%
Change Contribution By: 
Total Revenues ($ Mil)8869-21.8%
P/S Multiple1.62.983.0%
Shares Outstanding (Mil)99103-3.1%
Cumulative Contribution38.6%

LTM = Last Twelve Months as of date shown

Market Drivers

6/30/2025 to 1/27/2026
ReturnCorrelation
ALEC39.3% 
Market (SPY)12.9%26.9%
Sector (XLV)15.9%18.1%

Fundamental Drivers

The 2.6% change in ALEC stock from 12/31/2024 to 1/27/2026 was primarily driven by a 12.3% change in the company's Total Revenues ($ Mil).
(LTM values as of)123120241272026Change
Stock Price ($)1.891.942.6%
Change Contribution By: 
Total Revenues ($ Mil)626912.3%
P/S Multiple3.02.9-3.8%
Shares Outstanding (Mil)98103-4.9%
Cumulative Contribution2.6%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2024 to 1/27/2026
ReturnCorrelation
ALEC3.2% 
Market (SPY)19.7%28.0%
Sector (XLV)14.5%25.5%

Fundamental Drivers

The -79.0% change in ALEC stock from 12/31/2022 to 1/27/2026 was primarily driven by a -49.6% change in the company's P/S Multiple.
(LTM values as of)123120221272026Change
Stock Price ($)9.231.94-79.0%
Change Contribution By: 
Total Revenues ($ Mil)13369-48.2%
P/S Multiple5.72.9-49.6%
Shares Outstanding (Mil)83103-19.5%
Cumulative Contribution-79.0%

LTM = Last Twelve Months as of date shown

Market Drivers

12/31/2022 to 1/27/2026
ReturnCorrelation
ALEC-78.9% 
Market (SPY)88.6%26.8%
Sector (XLV)19.8%24.7%

Return vs. Risk

Price Returns Compared

 202120222023202420252026Total [1]
Returns
ALEC Return36%-55%-14%-76%-17%24%-87%
Peers Return-35%-18%22%-29%14%8%-43%
S&P 500 Return27%-19%24%23%16%2%85%

Monthly Win Rates [3]
ALEC Win Rate50%33%50%25%50%100% 
Peers Win Rate47%39%44%36%56%67% 
S&P 500 Win Rate75%42%67%75%67%100% 

Max Drawdowns [4]
ALEC Max Drawdown-2%-67%-59%-78%-52%-2% 
Peers Max Drawdown-43%-40%-20%-43%-31%-4% 
S&P 500 Max Drawdown-1%-25%-1%-2%-15%-1% 


[1] Cumulative total returns since the beginning of 2021
[2] Peers: DNLI, BIIB, ACAD.
[3] Win Rate = % of calendar months in which monthly returns were positive
[4] Max drawdown represents maximum peak-to-trough decline within a year
[5] 2026 data is for the year up to 1/27/2026 (YTD)

How Low Can It Go

Unique KeyEventALECS&P 500
2022 Inflation Shock2022 Inflation Shock  
2022 Inflation Shock% Loss% Loss-90.5%-25.4%
2022 Inflation Shock% Gain to Breakeven% Gain to Breakeven947.5%34.1%
2022 Inflation ShockTime to BreakevenTime to BreakevenNot Fully Recovered days464 days
2020 Covid Pandemic2020 Covid Pandemic  
2020 Covid Pandemic% Loss% Loss-73.4%-33.9%
2020 Covid Pandemic% Gain to Breakeven% Gain to Breakeven275.3%51.3%
2020 Covid PandemicTime to BreakevenTime to Breakeven259 days148 days

Compare to DNLI, BIIB, ACAD

In The Past

Alector's stock fell -90.5% during the 2022 Inflation Shock from a high on 7/7/2021. A -90.5% loss requires a 947.5% gain to breakeven.

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About Alector (ALEC)

Alector, Inc., a clinical stage biopharmaceutical company, develops therapies for the treatment of neurodegeneration diseases. Its products include AL001, a humanized recombinant monoclonal antibody, which is in Phase III clinical trial for the treatment of frontotemporal dementia, Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis diseases; and AL101 that is in Phase I clinical trial for the treatment of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. The company also offers AL002, a product candidate that is in Phase II clinical trial for the treatment of Alzheimer's disease; and AL003, which is in Phase I clinical trial for the treatment of Alzheimer's disease. In addition, its products in development stage include AL044 that targets MS4A4A, a risk gene for Alzheimer's disease. Alector, Inc. has a collaboration agreement with Adimab, LLC for the research and development of antibodies; and a strategic collaboration agreement with GlaxoSmithKline plc for the development and commercialization of monoclonal antibodies, such as AL001 and AL101 to treat neurodegenerative diseases. The company was founded in 2013 and is headquartered in South San Francisco, California.

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  • Moderna for brain diseases: Alector is a biotech company focused on developing innovative treatments for neurodegenerative conditions like Alzheimer's and Parkinson's, similar to Moderna's innovative approach to mRNA therapies.
  • Biogen, but focused purely on immuno-neurology: While Biogen has a broad focus on neurological diseases, Alector is singularly dedicated to leveraging the immune system to repair and protect the brain.

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  • AL001 (Lirumolimab): An investigational antibody designed to inhibit SIGLEC-3 (CD33) on microglia to treat Alzheimer's disease.
  • AL101: An investigational antibody targeting SIGLEC-F, currently being evaluated for the treatment of various neurodegenerative diseases.
  • AL002: An investigational antibody designed to activate TREM2 on microglia, aiming to treat Alzheimer's disease.
  • AL003: An investigational small molecule targeting CD33, currently in early-stage development for Alzheimer's disease.

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Alector (ALEC) is a biotechnology company primarily engaged in the research and development of therapies for neurodegenerative diseases. Its revenue is largely derived from collaboration agreements with other pharmaceutical companies rather than direct sales of approved products to individuals, as many of its programs are still in clinical development.

Alector's major customer is:

  • AbbVie Inc. (Symbol: ABBV) - AbbVie is Alector's key collaboration partner for the development and commercialization of multiple drug candidates, including AL002 and AL101, targeting neurodegenerative diseases. This collaboration is a significant source of Alector's revenue through upfront payments, milestone payments, and potential profit sharing.

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Arnon Rosenthal, Ph.D. Co-Founder, Chief Executive Officer, and Director

Dr. Rosenthal co-founded Alector in 2013 and has served as its Chief Executive Officer and a member of the Board of Directors since its inception. He also co-founded Annexon Biosciences, Inc., serving as its acting Chief Executive Officer from August 2011 to December 2014 and as Chairman of the Board of Directors until February 2017. Additionally, Dr. Rosenthal co-founded Rinat Neuroscience Corporation in 2001, where he served as President, Chief Scientific Officer, and a board member. Rinat Neuroscience Corporation, which discovered and developed the migraine drug Ajovy, was acquired by Pfizer Inc. in August 2006. From 1985 to 2001, he held various roles at Genentech, Inc., ultimately as Staff Scientist, where his team discovered the target for the cancer drug Erivedge. Dr. Rosenthal holds a Ph.D. in biology from the Hebrew University of Jerusalem.

Neil Berkley, M.S., M.B.A. Chief Business Officer and Interim Chief Financial Officer

Neil Berkley joined Alector in March 2024 as Chief Business Officer and assumed the role of interim Chief Financial Officer in June 2025. He brings over two decades of experience in corporate development, business development, and strategic planning across large pharma, midsize biotech/pharma, and small biotech companies. Before Alector, Mr. Berkley served as Chief Corporate Development Officer at Juvena Therapeutics, Chief Business Officer at AbCellera, and Vice President and Head of Business Development at Halozyme Therapeutics. He previously held leadership roles at Cadence Pharmaceuticals, Acadia, and GSK.

Sara Kenkare-Mitra, Ph.D. President and Head of Research and Development

Dr. Sara Kenkare-Mitra has served as President and Head of Research and Development at Alector since 2021. She is an experienced biotech/pharma drug developer, scientist, and executive with over 25 years of industry experience dedicated to developing novel drugs.

Giacomo Salvadore, M.D. Chief Medical Officer

Dr. Giacomo Salvadore was appointed Chief Medical Officer of Alector in April 2025, having joined the company in 2023 as Senior Vice President of Clinical Development. He leads Alector's global clinical development strategy and brings over 15 years of industry experience leading neurology and psychiatry programs. Prior to Alector, Dr. Salvadore was the Vice President of Translational Medicine at Acadia Pharmaceuticals and spent more than a decade at Janssen Research & Development, holding various leadership roles in clinical development for central nervous system programs. He received his M.D. from the University of Rome, Tor Vergata, and completed a postdoctoral fellowship at the National Institutes of Health.

Danielle Pasqualone, Ph.D., J.D. General Counsel

Dr. Danielle Pasqualone serves as the General Counsel for Alector.

AI Analysis | Feedback

The key risks to Alector's business (symbol: ALEC) include:

  1. Clinical Trial Failures and Pipeline Concentration: Alector faces significant risk due to its reliance on a concentrated pipeline and the inherent high failure rate of clinical trials in neurodegenerative diseases. The company experienced a major setback with the Phase 3 clinical trial failure of latozinemab (AL001) for frontotemporal dementia (FTD-GRN) in October 2025, leading to the discontinuation of the program. This failure removed Alector's most advanced late-stage asset and prompted analyst downgrades. Additionally, an earlier Phase 2 trial for AL002 in Alzheimer's disease also failed to meet its primary endpoint in November 2024. The company's next major clinical catalyst, nivisnebart (AL101/GSK4527226), targets Alzheimer's but shares a similar mechanistic link with the failed latozinemab, which could lead to weaker investor confidence.
  2. High Cash Burn and Volatile Collaboration Revenue: As a clinical-stage biotechnology company, Alector does not generate revenue from product sales and depends heavily on collaboration agreements, which are inherently volatile. The company reported a substantial year-over-year decline of 78.8% in collaboration revenue for Q3 2025, with figures dropping from $15.34 million in Q3 2024 to $3.26 million in Q3 2025. Alector consistently experiences a significant cash burn from its research and development (R&D) and general and administrative (G&A) expenses. While Alector has a robust cash, cash equivalents, and investments balance of $291.1 million as of September 30, 2025, which it anticipates will fund operations into 2027, the sustained cash outflow remains a core challenge.
  3. Impact of Significant Workforce Reduction: Following the latozinemab clinical trial failure, Alector implemented a major strategic pivot that included a significant workforce reduction of approximately 49% in October 2025. While intended to align resources and cut costs, this substantial reduction in staff could potentially slow down the progress of the remaining pipeline programs, even those considered promising.

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The clear emerging threat to Alector stems from the recent success and regulatory approvals of amyloid-beta targeting therapies for Alzheimer's disease.

  • Establishment of a New Standard of Care: With the full FDA approval of lecanemab (Leqembi) by Eisai/Biogen and the anticipated approval of donanemab by Eli Lilly, the landscape for Alzheimer's treatment has fundamentally shifted. These drugs represent the first disease-modifying therapies to demonstrate statistically significant slowing of cognitive decline.

  • Competitive Pressure on Market Share and Differentiation: While Alector's lead Alzheimer's programs (AL002 targeting TREM2 and AL003 targeting CD33) utilize distinct mechanisms of action (focusing on immune modulation and lysosomal function rather than amyloid clearance), the success of amyloid-beta therapies sets a high bar. Alector's candidates will need to demonstrate superior efficacy, safety, or applicability to specific patient populations (e.g., earlier disease stages, different genetic profiles) to compete effectively for market share and secure favorable reimbursement. The perception of a "first-in-class" treatment can make it challenging for subsequent therapies, even with different mechanisms, to gain traction unless their benefits are clearly superior or complementary.

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Alector (ALEC) is a biotechnology company focused on developing therapies for neurodegenerative diseases. The addressable markets for their main product candidates are as follows:

  • AL001 (Latozinemab) for Frontotemporal Dementia (FTD) caused by a progranulin (GRN) gene mutation: The market size for Frontotemporal Dementia across the seven major markets (7MM: United States, France, Germany, Italy, Spain, United Kingdom, and Japan) was valued at approximately USD 142.8 million in 2024. It is projected to reach USD 688.2 million by 2035, demonstrating a Compound Annual Growth Rate (CAGR) of 15.37% from 2025 to 2035. The global frontotemporal dementia management market is estimated to be valued at USD 396.1 million in 2025 and is forecast to grow to USD 626.4 million by 2035. In 2022, the United States market for FTD reached USD 67 million, representing approximately 61% of the total market size in the 7MM.

  • AL101 (Nivisnebart) and AL137 (ABC-enabled anti-amyloid beta antibody) for Alzheimer's Disease: The global Alzheimer's disease market, encompassing the eight major markets (8MM: United States, France, Germany, Italy, Spain, United Kingdom, Japan, and China), is expected to grow from $2.4 billion in 2023 to $19.3 billion by 2033, at a CAGR of 23.4%. More specifically for therapeutics, the global Alzheimer's therapeutics market size was estimated at USD 4.05 billion in 2022 and is anticipated to reach USD 15.19 billion by 2030, growing at a CAGR of 19.99% from 2023 to 2030. The Alzheimer's disease market across the top 7 regions (US, EU4, UK, and Japan) is projected to reach USD 6.3 billion by 2034, at a CAGR of 6.8% during 2024-2034. North America held the largest share of the Alzheimer's disease diagnostics and therapeutics market in 2025.

  • AL050 (ABC-enabled GCase enzyme replacement therapy) for Parkinson's Disease: The global Parkinson's disease therapeutics market was valued at USD 6.59 billion in 2024 and is predicted to increase to approximately USD 13.34 billion by 2034, expanding at a CAGR of 7.39% from 2025 to 2034. North America dominated the Parkinson's disease therapeutics market with the largest revenue share of 34.60% in 2024. Another estimate for the global Parkinson's disease drugs market size reports it was valued at USD 7.17 billion in 2024 and is projected to grow to USD 13.46 billion by 2032, exhibiting a CAGR of 8.2% from 2024 to 2032.

  • ADP064-ABC (ABC-enabled Tau siRNA) for Alzheimer's Disease and Frontotemporal Dementia (Tauopathies): The addressable market sizes are the same as those mentioned for Alzheimer's Disease and Frontotemporal Dementia.

  • AL002: null

  • Amyotrophic Lateral Sclerosis (ALS): null

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AI Analysis | Feedback

Alector (ALEC) is a clinical-stage biotechnology company focused on developing therapies for neurodegenerative diseases. Over the next two to three years, several key drivers are expected to influence its future revenue growth:

  1. Potential Commercialization of Latozinemab (AL001) for Frontotemporal Dementia (FTD-GRN): Alector anticipates topline data from the pivotal Phase 3 INFRONT-3 trial of latozinemab for frontotemporal dementia with a progranulin gene mutation (FTD-GRN) by mid-fourth quarter of 2025. If successful, latozinemab, which has received FDA Breakthrough Therapy, Orphan Drug, and Fast Track designations, could become the first disease-modifying therapy for this fatal neurodegenerative condition. Alector holds commercial rights in the U.S. with a 50-50 profit share agreement with GSK, alongside tiered double-digit royalties ex-U.S., paving the way for potential significant commercial revenues.
  2. Advancement of Nivisnebart (AL002/AL101) for Early Alzheimer's Disease: Data from the INVOKE-2 Phase 2 trial evaluating AL002 in patients with early Alzheimer's disease (AD) is on track for 2024. Additionally, enrollment in the global PROGRESS-AD Phase 2 clinical trial of AL101 in early AD is expected to complete by mid-2025. Positive results from these trials could trigger substantial development and commercial milestone payments from Alector's collaboration partner, GSK, and further advance AL101/AL002 toward later-stage development and eventual commercialization.
  3. Progression of Alector Brain Carrier (ABC) Platform-Enabled Pipeline: Alector's proprietary Alector Brain Carrier (ABC) technology platform is designed to enhance the delivery of therapeutic molecules across the blood-brain barrier for various neurodegenerative diseases. The company is advancing several preclinical programs utilizing this platform, including candidates for Alzheimer's and Parkinson's diseases (e.g., ADP037-ABC, ADP050-ABC, ADP064-ABC). The potential initiation of first-in-human trials for these ABC-enabled programs in 2026 and 2027 could lead to new collaboration agreements and milestone payments, increasing the company's long-term revenue potential and overall valuation.
  4. Strategic Milestone Payments from Collaborations: While collaboration revenue has seen fluctuations due to the completion of certain performance obligations from prior agreements, future milestone payments tied to the clinical and regulatory progress of Alector's partnered programs, particularly with GSK for latozinemab and nivisnebart, represent a significant potential revenue stream. These payments could be triggered by achievements such as regulatory approvals and initial commercial sales in various territories.

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Share Issuance

  • Alector completed a public offering in February 2020, generating approximately $240.0 million in gross proceeds from the sale of 9,602,500 shares of common stock at $25.00 per share.
  • In late 2023 or early 2024, the company issued 10,869,566 shares of common stock at $6.57 per share, yielding aggregate net proceeds of $71.1 million after offering costs.
  • Through at-the-market (ATM) equity offerings, Alector raised approximately $14.7 million in net proceeds in September 2025 and an additional $5.3 million in October 2025.

Inbound Investments

  • Alector maintains a strategic collaboration with GlaxoSmithKline (GSK) for developing and commercializing progranulin-elevating monoclonal antibodies, which included $700 million in upfront payments and up to $1.5 billion in potential development and commercial milestones.
  • Collaboration revenue for 2024 was $100.6 million.
  • The company projects collaboration revenue for 2025 to be between $13 million and $18 million.

Capital Expenditures

  • Alector's cash, cash equivalents, and investments totaled $291.1 million as of September 30, 2025, which is anticipated to fund operations through 2027.
  • Total research and development expenses, a primary focus of capital allocation, were $29.4 million for the third quarter of 2025, a decrease from $48.0 million in the same period of 2024. This reduction reflects program completions and strategic workforce adjustments.
  • For the full year 2025, Alector anticipates total research and development expenses to range from $130 million to $140 million.

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Unique Key

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Peer Comparisons

Peers to compare with:

Financials

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Mkt Price1.9421.26174.4326.2023.73
Mkt Cap0.23.725.64.44.0
Rev LTM69010,0661,047558
Op Inc LTM-124-5482,49294-15
FCF LTM-198-4122,26299-49
FCF 3Y Avg-203-3781,68670-67
CFO LTM-197-3982,4541991
CFO 3Y Avg-202-3641,980103-49

Growth & Margins

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Rev Chg LTM12.3%-4.8%12.7%12.3%
Rev Chg 3Y Avg-17.2%--0.9%27.8%-0.9%
Rev Chg Q-78.8%-2.8%11.3%2.8%
QoQ Delta Rev Chg LTM-14.9%-0.7%2.8%0.7%
Op Mgn LTM-179.1%-24.8%9.0%9.0%
Op Mgn 3Y Avg-215.4%-22.5%-1.1%-1.1%
QoQ Delta Op Mgn LTM-13.3%-0.7%0.2%0.2%
CFO/Rev LTM-285.8%-24.4%19.0%19.0%
CFO/Rev 3Y Avg-279.7%-20.0%8.7%8.7%
FCF/Rev LTM-286.2%-22.5%9.5%9.5%
FCF/Rev 3Y Avg-281.6%-17.0%5.5%5.5%

Valuation

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
Mkt Cap0.23.725.64.44.0
P/S2.9-2.54.22.9
P/EBIT-1.6-6.711.846.95.1
P/E-1.8-7.315.916.97.0
P/CFO-1.0-9.210.422.24.7
Total Yield-53.9%-13.6%6.3%5.9%-3.9%
Dividend Yield0.0%0.0%0.0%0.0%0.0%
FCF Yield 3Y Avg-90.8%-12.4%6.5%2.4%-5.0%
D/E0.20.00.30.00.1
Net D/E-1.3-0.20.1-0.2-0.2

Returns

ALECDNLIBIIBACADMedian
NameAlector Denali T.Biogen ACADIA P. 
1M Rtn33.8%26.0%-1.5%-5.1%12.3%
3M Rtn29.3%25.7%17.0%15.8%21.3%
6M Rtn20.5%56.2%36.4%15.8%28.4%
12M Rtn11.5%-8.3%17.3%43.4%14.4%
3Y Rtn-78.8%-32.4%-39.9%41.1%-36.2%
1M Excs Rtn33.1%24.5%-1.8%-6.7%11.4%
3M Excs Rtn26.6%30.5%13.6%16.2%21.4%
6M Excs Rtn1.1%46.8%25.7%6.6%16.2%
12M Excs Rtn-5.9%-18.7%4.9%26.0%-0.5%
3Y Excs Rtn-152.2%-102.6%-114.8%-40.3%-108.7%

Comparison Analyses

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Financials

Segment Financials

Revenue by Segment
$ Mil20242023202220212020
Single Segment97    
Collaboration revenue 1342072121
Total971342072121


Price Behavior

Price Behavior
Market Price$1.95 
Market Cap ($ Bil)0.2 
First Trading Date02/07/2019 
Distance from 52W High-41.3% 
   50 Days200 Days
DMA Price$1.50$1.78
DMA Trendupdown
Distance from DMA30.3%9.8%
 3M1YR
Volatility62.8%106.4%
Downside Capture73.79253.76
Upside Capture219.49227.01
Correlation (SPY)34.9%27.4%
ALEC Betas & Captures as of 12/31/2025

 1M2M3M6M1Y3Y
Beta1.641.982.313.091.511.54
Up Beta-1.371.931.361.950.740.96
Down Beta0.273.381.741.571.541.74
Up Capture470%191%139%703%419%214%
Bmk +ve Days11233772143431
Stock +ve Days12203167129379
Down Capture76%129%366%305%155%112%
Bmk -ve Days11182755108320
Stock -ve Days6152549107346

[1] Upside and downside betas calculated using positive and negative benchmark daily returns respectively
Based On 1-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC13.5%106.3%0.65-
Sector ETF (XLV)9.2%17.3%0.3525.0%
Equity (SPY)15.5%19.3%0.6227.2%
Gold (GLD)87.8%20.6%2.98-0.3%
Commodities (DBC)10.6%15.5%0.451.3%
Real Estate (VNQ)3.6%16.5%0.0417.0%
Bitcoin (BTCUSD)-15.6%39.7%-0.3318.2%

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Based On 5-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC-35.0%87.3%-0.09-
Sector ETF (XLV)7.2%14.5%0.3228.5%
Equity (SPY)14.1%17.1%0.6632.2%
Gold (GLD)22.3%15.7%1.144.6%
Commodities (DBC)12.3%18.7%0.533.0%
Real Estate (VNQ)4.8%18.8%0.1628.3%
Bitcoin (BTCUSD)20.0%57.9%0.5515.4%

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Based On 10-Year Data
Annualized
Return
Annualized
Volatility
Sharpe
Ratio
Correlation
with ALEC
ALEC-19.6%84.3%0.02-
Sector ETF (XLV)10.6%16.6%0.5333.4%
Equity (SPY)15.8%17.9%0.7634.6%
Gold (GLD)16.5%14.9%0.922.6%
Commodities (DBC)8.9%17.6%0.427.6%
Real Estate (VNQ)5.9%20.8%0.2528.6%
Bitcoin (BTCUSD)72.5%66.5%1.1114.9%

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Short Interest

Short Interest: As Of Date1152026
Short Interest: Shares Quantity6.5 Mil
Short Interest: % Change Since 123120256.0%
Average Daily Volume1.2 Mil
Days-to-Cover Short Interest5.2 days
Basic Shares Quantity102.6 Mil
Short % of Basic Shares6.3%

Earnings Returns History

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 Forward Returns
Earnings Date1D Returns5D Returns21D Returns
10/21/2025-49.8%-53.3%-62.0%
8/7/202547.3%68.5%89.0%
5/8/202512.5%6.2%38.5%
2/26/2025-3.5%-9.9%-22.7%
11/6/20247.6%-2.2%-58.8%
8/7/20243.9%-1.0%-1.2%
5/8/20240.2%8.9%-16.0%
2/27/2024-0.3%-3.9%-13.3%
...
SUMMARY STATS   
# Positive1186
# Negative101315
Median Positive7.6%7.6%13.8%
Median Negative-4.8%-9.1%-13.3%
Max Positive47.3%68.5%89.0%
Max Negative-49.8%-53.3%-62.0%

SEC Filings

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Report DateFiling DateFiling
09/30/202511/06/202510-Q
06/30/202508/07/202510-Q
03/31/202505/08/202510-Q
12/31/202402/26/202510-K
09/30/202411/06/202410-Q
06/30/202408/07/202410-Q
03/31/202405/08/202410-Q
12/31/202302/27/202410-K
09/30/202311/07/202310-Q
06/30/202308/03/202310-Q
03/31/202305/04/202310-Q
12/31/202202/28/202310-K
09/30/202211/08/202210-Q
06/30/202208/04/202210-Q
03/31/202205/05/202210-Q
12/31/202102/24/202210-K

Insider Activity

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#OwnerTitleHoldingActionFiling DatePriceSharesTransacted
Value
Value of
Held Shares
Form
1Wong-Sarad, GracePrincipal Accounting OfficerDirectSell120820251.214,7535,751148,808Form
2Wong-Sarad, GracePrincipal Accounting OfficerDirectSell120320251.128,0569,019142,999Form
3Rosenthal, ArnonChief Executive OfficerDirectSell120320251.12104,347116,8272,709,477Form
4Kenkare-Mitra, SaraPresident and Head of R&DDirectSell120320251.1241,68746,673561,650Form
5Berkley, Neil LindsayChief Bus Ofcr & Interim CFODirectSell120320251.1237,26141,717419,076Form