Market Movers | Winners: SDGR, CYPH, INDP | Losers: FLNC, AN, GBLI
Today’s biggest market moves are not always what they seem, with some sharp gains and losses accelerating trends that were already weeks in the making.
The S&P 500 returned +1.1% while the Nasdaq-100 returned +1.7%. The day’s extremes were wide, with Schrodinger (SDGR) returning +26.4% while Fluence Energy (FLNC) returned -15.4%. This raises a key question for today’s tape: are the sharpest moves fresh starts, or the continuation of trends already in motion? The day’s largest percentage moves are below.
Thursday’s Market Winners
The 10 US-listed stocks in the Trefis coverage universe with the highest returns on the last trading day:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | SDGR | Schrodinger | 26.4% | 69.1% |
| 2 | CYPH | Cypherpunk Technologies | 25.8% | 164.7% |
| 3 | INDP | Indaptus Therapeutics | 22.4% | 35.1% |
| 4 | GNRC | Generac | 18.3% | 52.0% |
| 5 | VICR | Vicor | 17.7% | 97.4% |
| 6 | VITL | Vital Farms | 16.7% | -63.4% |
| 7 | EYPT | EyePoint | 15.7% | -78.2% |
| 8 | ABSI | Absci | 15.3% | 165.6% |
| 9 | TEM | Tempus AI | 14.8% | 36.1% |
| 10 | FISN | Deep Fission | 14.4% | n/a |
Thursday’s Market Losers
And the 10 US-listed stocks in the Trefis coverage universe with the lowest returns:
| # | Ticker | Company Name | 1-D Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | FLNC | Fluence Energy | -15.4% | -61.3% |
| 2 | AN | AutoNation | -10.5% | -15.3% |
| 3 | GBLI | Global Indemnity | -9.5% | -1.8% |
| 4 | SAH | Sonic Automotive | -9.3% | 8.4% |
| 5 | ASTH | Astrana Health | -9.0% | 38.3% |
| 6 | MAMA | Mama’s Creations | -8.0% | -2.8% |
| 7 | MTZ | MasTec | -7.9% | -4.4% |
| 8 | DKNG | DraftKings | -7.6% | -34.8% |
| 9 | ANGX | Angel Studios | -7.5% | 4.9% |
| 10 | XRAY | Dentsply Sirona | -7.5% | -18.0% |
Are these moves new, or just louder?
The day’s extremes show persistence. The top gainer, Schrodinger (SDGR), also appears on the one-month winners list with a total return of +71.1%. Its strength extends beyond a single session, as it still gained +35.4% over the other periods.
The pattern holds for the biggest loser, Fluence Energy (FLNC), which is also on the one-month losers list. Its one-month return is -34.8%, and it still lost 23.0% over the other sessions.
Movers Over The Last Week
Widening the window to five trading days, these are the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | SDGR | Schrodinger | 60.9% | 69.1% |
| 2 | INDP | Indaptus Therapeutics | 53.5% | 35.1% |
| 3 | ACVA | ACV Auctions | 45.2% | 30.7% |
| 4 | CYPH | Cypherpunk Technologies | 39.5% | 164.7% |
| 5 | ELMT | Elmet | 38.0% | n/a |
| 6 | TEM | Tempus AI | 36.8% | 36.1% |
| 7 | EMAT | Evolution Metals & Technologies | 30.5% | n/a |
| 8 | BBNX | Beta Bionics | 29.2% | -29.7% |
| 9 | CAI | Caris Life Sciences | 28.6% | 14.6% |
| 10 | FOSL | Fossil | 25.4% | 49.7% |
Losers
| # | Ticker | Company Name | 1-W Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | SWMR | Swarmer | -33.2% | n/a |
| 2 | ALHC | Alignment Healthcare | -31.8% | -55.9% |
| 3 | ALMS | Alumis | -21.0% | -19.9% |
| 4 | FLNC | Fluence Energy | -20.9% | -61.3% |
| 5 | ENVA | Enova International | -19.7% | 13.9% |
| 6 | ARTV | Artiva Biotherapeutics | -19.0% | 96.7% |
| 7 | ARWR | Arrowhead Pharmaceuticals | -18.1% | 2.0% |
| 8 | SPRY | ARS Pharmaceuticals | -18.0% | -64.4% |
| 9 | MPLT | MapLight Therapeutics | -17.9% | -35.6% |
| 10 | ASMB | Assembly Biosciences | -16.8% | -25.5% |
Movers Over The Last Month
And over the last 21 trading days, the strongest and weakest names in the Trefis coverage universe:
Winners
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | INDP | Indaptus Therapeutics | 319.8% | 35.1% |
| 2 | CYPH | Cypherpunk Technologies | 281.2% | 164.7% |
| 3 | MRNA | Moderna | 151.1% | 436.0% |
| 4 | ARCT | Arcturus Therapeutics | 106.2% | 176.2% |
| 5 | BRR | ProCap Financial | 80.1% | -2.5% |
| 6 | PURR | Hyperliquid Strategies | 78.2% | 260.4% |
| 7 | SDGR | Schrodinger | 71.1% | 69.1% |
| 8 | TEM | Tempus AI | 62.8% | 36.1% |
| 9 | EBS | Emergent BioSolutions | 50.6% | -43.2% |
| 10 | CVI | CVR Energy | 47.7% | 114.1% |
Losers
| # | Ticker | Company Name | 1-M Returns |
YTD Returns |
|---|---|---|---|---|
| 1 | ALMS | Alumis | -68.6% | -19.9% |
| 2 | SWMR | Swarmer | -48.7% | n/a |
| 3 | RARE | Ultragenyx Pharmaceutical | -43.1% | -37.0% |
| 4 | KRMN | Karman | -40.7% | -51.8% |
| 5 | TTAN | ServiceTitan | -40.5% | -49.1% |
| 6 | ALOY | REalloys | -38.9% | n/a |
| 7 | IMUX | Immunic | -38.8% | 93.9% |
| 8 | FLNC | Fluence Energy | -34.8% | -61.3% |
| 9 | FBYD | Falcons Beyond Global | -34.8% | -54.2% |
| 10 | DKS | Dick’s Sporting Goods | -34.7% | -36.0% |
A big move is a question, not an answer.
The tables of market movers earlier in this report are a map of market attention. A large percentage change is information about risk and investor focus. It is never an instruction to act.
The disciplined response is to check the business behind the ticker. For example, Schrodinger (SDGR) has a market value of about $2.3 billion and its revenue grew 8.9% over the last twelve months. This is the starting point for actual research, not the end.
Either side of these lists can be a lead worth following, with the same follow-up question: does the business back the move? For the winners, our Guidance Momentum screen tracks which companies raised their own forward numbers. For the losers, our Buy the Dip screen flags which marked-down names still have the fundamentals to recover.
Volatility Is The Cost Of Owning Stocks. Concentration Makes It A Bill
Every name on these lists made a move big enough to notice. A diversified holder reads that as noise; a concentrated holder feels it as real money. The difference is not the stock, it is the portfolio around it.
Building that portfolio is what the Trefis High Quality (HQ) Portfolio does: roughly 30 businesses with the cash generation and balance-sheet strength to absorb bad days, selected and rebalanced by rules. It has a track record of outpacing a benchmark that combines the S&P 500, the S&P MidCap 400, and the Russell 2000. Let the movers list remind you why diversification exists.