Is Intuitive Surgical Stock Poised For Growth?

+18.34%
Upside
526
Market
622
Trefis
ISRG: Intuitive Surgical logo
ISRG
Intuitive Surgical

Intuitive Surgical delivered solid Q4 2025 results with adjusted EPS of $2.53, surpassing estimates of $2.26 and up 14.5% from Q4 2024’s $2.21. Revenue hit $2.87 billion, up 19% year-over-year and beating the $2.75 billion consensus, while full-year revenue reached $10.1 billion (+21%) with adjusted EPS of $8.93. Does this performance support pushing the valuation higher despite tempered 2026 guidance?

What’s the valuation story telling us? At current levels around $526, ISRG trades at 59x its trailing adjusted EPS of $8.93, in line with the five-year average of 60x. This consistency raises a key question: can solid procedure momentum, new platform demand, and robust profitability justify pushing the multiple higher?

That being said, if you seek an upside with less volatility than holding an individual stock like ISRG, consider the High Quality Portfolio. It has comfortably outperformed its benchmark—a combination of the S&P 500, Russell, and S&P MidCap indexes—and has achieved returns exceeding 105% since its inception. Why is that? As a group, HQ Portfolio stocks provided better returns with less risk versus the benchmark index; less of a roller-coaster ride, as evident in HQ Portfolio performance metrics. Separately, see – The Binary Bet: QuantumScape’s Path To Doubling.

How did Q4 operations measure up?

Worldwide da Vinci procedures grew 18%, fueled by U.S. general surgery gains and 23% international expansion. Recurring revenue – 81% of the total at $2.3 billion – rose 20%, highlighting the annuity model’s power. Pro forma operating margins reached 37%, with GAAP income from operations at $864 million. Look at Intuitive Surgical’s financials for more details.

Key Business Drivers

  • Procedure Momentum: Global procedures expanded 18% for the full year, with international markets accelerating to 23% growth. Da Vinci 5 drove adoption in multi-port and single-port procedures, building surgeon preference through superior visualization and ergonomics.
  • Revenue Composition: Systems contributed steadily to installed base growth, while instruments and services dominated profitability. The quarter’s 19% revenue growth reflected pricing discipline and higher utilization across a broader base.
  • Financial Leverage: Annual free cash flow doubled to $2.5 billion from $1.3 billion, funding $2.3 billion in share repurchases at an average $478 price. Pro forma net income hit $914 million in Q4, up from $805 million last year.

2026 Guidance Context

Management forecasts 13%-15% worldwide procedure growth, decelerating from 2025’s 18% due to comparisons and capacity factors. Adjusted EPS guidance of $9.80-$10.00 implies 10%-12% growth. Does this conservatism create a buying opportunity?

Valuation Perspectives

Is 59x poised for expansion?

Historical consistency at 60x feels comfortable, but high-teens growth in procedures, industry-leading margins, and platform upgrades argue for a premium. Why cap the multiple when execution consistently beats expectations?

  • Upside Catalysts: Exceeding 13%-15% guidance through da Vinci 5 ramp, international penetration, and new indications offer clear paths higher. FCF strength supports returns while funding R&D.
  • Potential Headwinds: Growth deceleration to 13%-15% may challenge sentiment, especially if hospital budgets tighten on elective procedures. Supply chain or competitive pressures remain watch items.

The Bottom Line

ISRG’s Q4 beat – 14.5% EPS growth to $2.53, 19% revenue to $2.87 billion, and 18% procedures – reinforces premium fundamentals, supporting multiple expansion potential from 59x despite cautious 2026 guidance. Our $622 price estimate for ISRG stock awaits revision to incorporate these results, likely retaining meaningful upside as execution quality outweighs the slowdown narrative.

Remember, investing in a single stock without comprehensive analysis can be risky. Consider the Trefis Reinforced Value (RV) Portfolio, which has outperformed its all-cap stocks benchmark (combination of the S&P 500, S&P mid-cap, and Russell 2000 benchmark indices) to produce strong returns for investors. Why is that? The quarterly rebalanced mix of large-, mid-, and small-cap RV Portfolio stocks provided a responsive way to make the most of upbeat market conditions while limiting losses when markets head south, as detailed in RV Portfolio performance metrics.

Invest with Trefis Market-Beating Portfolios
See all Trefis Price Estimates